For good health, the body must be able to keep insulin and glucose levels in balance. With too little insulin, blood sugar remains higher than normal (a condition known as hyperglycemia) and cells can't get the energy they need. With too much insulin, blood sugar decreases (hypoglycemia), causing symptoms such as sweating, trembling, lightheadedness, and in extreme cases, shock. The most common cause of abnormal fluctuations in blood sugar is diabetes.
Renin is also called angiotensinogenase; it’s an enzyme produced by the kidneys to control aldosterone production. It’s also essential in the renin–angiotensin aldosterone system (RAAS) which maintains your body’s fluid balance and blood pressure. Aldosterone is the primary of several endogenous members of the class of mineralocorticoids in humans. Aldosterone tends to promote Na+ and water retention, and lower plasma K+ concentration.
Approximately 95% of IGF-1 and IGF-II are bound to IGFBP-3, which makes this protein the major carrier of the insulin-like growth factors in circulation. The function of the binding protein is to extend the half-life of the growth factors in the circulation.