Tissue Transglutaminase (tTG)

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Tissue Transglutaminase (tTG)
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Overview

Detection of antibodies to aid in the diagnosis of gluten-sensitive enteropathy (GSE), such as celiac disease and dermatitis herpetiformis

Detection of antibodies to aid in the diagnosis of gluten-sensitive enteropathy (GSE), such as celiac disease and dermatitis herpetiformis

Limitations

A negative tTG IgA result in an untreated patient does not rule out gluten-sensitive enteropathy. This result can often be explained by selective IgA deficiency, a relatively frequent finding in celiac disease. The results of this assay should be used in conjunction with clinical findings and other serological tests.