Elevated levels of homocysteine in the blood, known as hyperhomocysteinemia, have been linked to an increased risk of cardiovascular disease, including heart attack and stroke. High homocysteine levels may also be associated with an increased risk of certain other health conditions, such as osteoporosis and pregnancy complications.

Vitamin B-12 is an essential vitamin. Low blood levels of B12 can cause: Anemia and pernicious anemia, loss of balance , numbness or tingling in the arms and legs, and weakness

B12 and folic acid blood testing help doctors diagnose central nervous system disorders, anemia, and malabsorption syndromes. B12 and folic acid also play an important role in energy level, muscle strength and memory. Because B12 and folate are derived solely from dietary intake, such as egg yolks, beef, poultry and fish, many people are deficient in these important vitamins.

SHBG (sex hormone binding globulin) binds to testosterone and estradiol. High SHBG may decrease free testosterone and free estradiol.