Thyroxine-binding Globulin (TBG), Serum

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Thyroxine-binding Globulin (TBG), Serum
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Overview

Thyroxine-binding globulin (TBG) is a globulin that binds thyroid hormones in circulation. It is one of three transport proteins (along with transthyretin and serum albumin) responsible for carrying the thyroid hormones thyroxine (T4) and triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3 but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in the blood plasma.

Thyroxine-binding globulin (TBG) is a globulin that binds thyroid hormones in circulation. It is one of three transport proteins (along with transthyretin and serum albumin) responsible for carrying the thyroid hormones thyroxine (T4) and triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3 but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in the blood plasma.

Interpretation: General


TBG effects measurement of total T4 and T3

Increased TBG increases total T4 and T3 measurements

Decreased percent Free T4 and T3

No change in Free T4 and Free T3

Decreased TBG decreases total T4 and T3 measurements

Increased percent Free T4 and T3

No change in Free T4 and Free T3

Labs unaffected by Thyroid Binding Globulin (TBG):

Free Thyroxine Index (FTI)

Calculation based on T3 Resin Uptake

Free Thyroxine (Free T4)

Free Triiodothyronine (Free T3)

Factors that Increase TBG (Reduces total T4 and T3 measurements)

Pregnancy

Newborn state

Chronic Active Hepatitis

Biliary Cirrhosis

Infection

Acute intermittent porphyria

Familial hyperthyroxinemia

Drugs

Oral Contraceptives

Estrogens

Tamoxifen

Methadone

Heroin

Perphenazine

Factors that decrease TBG (Elevates total T4 and T3 measurements)

Chronic Liver Disease

Obstructive Jaundice or Cirrhosis

Severe systemic illness

Active Acromegaly

Nephrotic Syndrome

Surgical Stress

Opiates

Depakote

Depakene

Dilantin

Phenothiazines

Androgens (testosterone, anabolic steroids)

Salicylates

L-asparaginase

Large doses of glucocorticoids (Prednisone)

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