This hormone panel for men on testosterone replacement therapy (TRT) contains upstream and downstream hormones to testosterone.  TRT has been shown to decrease upstream hormones like pregnenolone and progesterone, and slightly decrease DHEA. Downstream hormone metabolites like ultrasensitive estradiol and DHT are also included.  Lastly, prolactin is added since high prolactin can decrease sexual function.  No LH and FSH were included since TRT shuts them down.

FSH and LH are produced by the pituitary gland to control the production of sex hormones including testosterone and estrogen, and sperm and egg cells. They are both important in diagnosing primary or secondary hypogonadism, infertility, or potential pituitary adenomas.

 Progesterone is a female hormone important for the regulation of ovulation and menstruation. It is also present in men in smaller concentrations. Progesterone is a steroid hormone that plays numerous roles within the human body. It is crucial to the production of sex hormones and corticosteroids, as well as playing a role as a neuro-steroid (brain function). 

This fertility panel for women contains the main hormones tested (most using the most sensitive liquid chromatography/mass spectrometry) by reproductive endocrinologists to assess the potential for a woman to become pregnant.  Tests included are: LH, FSH, Anti-Müllerian Hormone (AMH), estradiol (LC/MS), progesterone (LC/MS), TSH and testosterone (LC/MS).

This panel includes: Testosterone, Total, LC/MS and Free (Equilibrium Dialysis), and 17-OH-progesterone, a metabolite that has been correlated with sperm production.

Testosterone Replacement Therapy (TRT) shuts down upstream hormones like LH and FSH required for sperm production, so men on TRT generally have a difficult time fathering a child. Some studies show that adding hCG to a TRT protocol may improve sperm production since hCG is an analog of LH that could stimulate sperm production. But optimizing hCG dose and frequency based on sperm count can be a time consuming process since it takes at least 8 weeks to see changes in sperm tests. Fortunately, there is an easier way by measuring 17-OH-progesterone to predict the efficacy of the hCG+TRT protocol without having to wait for 8 weeks between hCG dose/frequency changes. 

This hormone panel for women contains all basic hormones (except for LH and FSH, which you can add to your cart separately): DHEA-S, Estradiol (CLIA assay), Progesterone, Total Testosterone, LC/MS, Free Testosterone by Equilibrium Ultrafiltration, TSH,Free T3 and Free T4

This is the most accurate progesterone test that has no potential interactions and can detect very low levels in men and women.  Since it is performed with liquid chromatography and mass spectrometry, results are available after 5 to 7 business days.

To find out if sperm count is normalized in men using hCG plus TRT, several studies have found that 17OH-P blood level is correlated to intratesticular testosterone (ITT) required for the testicles to make sperm, so testing for this hormone could not only save time while optimizing HCG dose/frequency but also eliminate the need to perform testicular aspirations, a very difficult procedure to do. Sperm count does not stabilize until 6-8 weeks after starting hCG plus TRT, so knowing your 17OH-progesterone blood level can give you a quick way to determine if your hCG dose and frequency is adequate before your first follow-up semen analysis after 8 weeks.