Men's Health Lab Tests

Your hormones control everything from energy and strength to recovery and muscle-building. Regular testing can identify imbalances that hold you back and help fine-tune your training, diet, and recovery. Here’s a quick summary of the 8 key hormone tests every athlete and bodybuilder should know about: Testosterone: Measures muscle growth and recovery potential. Cortisol: Tracks stress and recovery balance. Growth Hormone (GH): Supports muscle repair and fat metabolism. Thyroid Function: Regulates energy and metabolism. IGF-1: Reflects growth hormone activity for muscle building. Estradiol: Affects recovery, bone health, and fat distribution. DHEA: Precursor to testosterone and estrogen, key for hormonal balance. LH & FSH: Monitors reproductive health and testosterone production. Why it matters: Hormonal imbalances can lead to fatigue, poor recovery, and reduced performance. Testing provides actionable data to optimize training and avoid overtraining. Pro Tip: Start with a testosterone-to-cortisol ratio or thyroid panel if you're noticing fatigue, slow recovery, or muscle loss. Dive into the full article for details on each test and how to use them to improve your results. Fitness Improvement Requires Stress & Cortisol 1. Testosterone Levels Testing testosterone levels is crucial for athletes, as it directly affects muscle growth, recovery, and overall performance. Understanding Testosterone Testing Blood tests are used to measure two key types of testosterone: total testosterone (which includes both free and protein-bound forms) and free testosterone (the active form). For the most accurate results, it's recommended to test between 7 a.m. and 10 a.m., when levels are naturally highest [3]. Services like DiscountedLabs.com offer hormone panels at over 2,200 locations across the U.S., delivering confidential results in just 2–7 business days. This detailed measurement helps assess performance potential and identify areas for improvement. Normal Testosterone Ranges for Athletes Gender Normal Range (ng/dL) Men 300–1,000 Women 15–70 Dr. Paul Gittens, a board-certified urologist and founder of the Rockwell Centers for Sexual Medicine and Wellness, emphasizes: "It's not all about numbers. It's about how your numbers reflect with your symptoms." [2] How Testosterone Affects Athletic Performance Maintaining balanced testosterone levels is essential for any athlete aiming to maximize strength and recovery. Testosterone supports several key functions, including: Promoting muscle protein synthesis Maintaining bone density Speeding up post-workout recovery Regulating fat distribution It's worth noting that testosterone levels naturally decline by about 1.6% per year, which can influence performance over time. Signs of Low Testosterone Be alert to these potential warning signs of low testosterone: Loss of muscle mass despite consistent training Longer recovery periods after workouts Reduced strength gains Unusual fatigue during exercise Lack of motivation to train Dr. Justin Dubin, a urologist and men's health expert at Memorial Healthcare System, points out: "Just because your testosterone is very, very high doesn't mean you have a better libido or anything. Everyone's body is different." [2] 2. Cortisol Measurement Cortisol, often referred to as the "stress hormone", can directly impact recovery and performance when levels remain elevated for too long. For athletes and bodybuilders, keeping cortisol in check is key to improving training outcomes. This hormone plays a role in regulating metabolism, immune response, and inflammation [7]. Testing Methods and Timing Cortisol levels can be assessed using three primary methods: Test Type Collection Time Normal Range (8 a.m.) Blood Test Morning + 4 p.m. 5-25 mcg/dL Saliva Test Before bedtime Varies by lab 24-hour Urine Full day collection Lab-specific Impact on Athletic Performance When exercise intensity exceeds 60% of VO2 max, cortisol levels naturally rise [6]. While short-term spikes are part of the body's normal response, consistently high levels can lead to: Poor muscle recovery Weakened immune function Loss of bone density Trouble sleeping Increased fat storage Professor Chris McLellan highlights the importance of monitoring cortisol: "Cortisol testing provides coaches, trainers and health & fitness professionals with increased capacity in conjunction with existing performance monitoring methods to establish preparedness for training and competition and optimize recovery. With cortisol, what gets measured, gets managed." [4] Understanding these effects is just the first step. The next challenge is learning how to control elevated cortisol levels. Managing Cortisol Levels Overtraining can cause a surge in cortisol that slows recovery and breaks down muscle tissue [8]. To keep cortisol levels balanced: Post-workout nutrition: After exercise, drink a carb-to-protein mix in a 3:1–4:1 ratio to help regulate cortisol [5]. Training structure: Build workout routines that include proper rest periods, especially for endurance-focused athletes [5]. Recovery strategies: Incorporate stress management techniques and prioritize high-quality sleep [4]. 3. Growth Hormone Testing Growth hormone (GH) testing plays an important role for athletes and bodybuilders aiming to improve performance and recovery. Since GH levels naturally rise and fall throughout the day, accurate testing can reveal useful details about hormonal health and how well training is working. Testing Methods and Accuracy Measuring GH isn't straightforward because of its pulsatile secretion pattern. Standard blood tests aren't enough. Instead, endocrinologists rely on specialized tests: Test Type Purpose Normal Range Approximate Cost IGF-1 Blood Test Primary screening Age/gender specific $70 GH Stimulation Diagnose deficiency >4 ng/mL (adults) Varies GH Suppression Diagnose excess <1 ng/mL Varies Macimorelin Test Oral diagnostic ≤2.8 μg/L Varies Dr. Jennifer Osipoff, a Pediatric Endocrinologist at Stony Brook Children's Hospital, notes: "A random GH level is not a clinically relevant value if assessing for growth hormone deficiency or excess. Instead, endocrinologists will measure insulin-like growth factor 1 (IGF-1), a protein that is made in response to GH secretion." [10] Impact on Athletic Performance GH plays a role in muscle growth, protein synthesis, fat metabolism, and recovery. Studies show that athletes using GH supplementation gained an average of 4.6 pounds of lean body mass [11]. However, GH alone doesn't lead to noticeable improvements in strength or exercise performance. This underscores the importance of focusing on natural ways to optimize GH levels. Natural GH Optimization Tracking GH levels can help adjust training plans. Here are some insights: Women produce about 50% more GH than men over a 24-hour period [9]. GH production decreases by roughly 14% per decade after early adulthood [9]. Anaerobic workouts stimulate more GH release compared to steady-state cardio [9]. Testing Considerations When preparing for GH testing, keep the following in mind: Follow fasting guidelines carefully. Inform your doctor about any medications that could affect results. Schedule tests at times when GH levels are most likely to be measurable. Consider pairing GH testing with IGF-1 measurement for a more complete picture. 4. Thyroid Function Tests Thyroid tests provide important insights for athletes looking to refine their training. These hormones play a key role in metabolism, muscle function, and overall performance, making thyroid health essential for athletic success. Core Thyroid Panel Components Test Type Purpose Indicator TSH (Thyroid Stimulating Hormone) Initial screening test General thyroid function Free T4 Measures active thyroid hormone Direct thyroid output Free T3 Measures active thyroid hormone Reflects metabolic activity Thyroid Antibodies Identifies autoimmune issues Autoimmune conditions How Thyroid Hormones Affect Performance Thyroid hormones impact several areas critical to athletes: Muscle strength, recovery, and protein synthesis Energy production and usage Heart rate and blood pressure regulation Body temperature control Weight stability Dr. Sumedha Chablani, an endocrinologist and clinical assistant professor at NYU Grossman School of Medicine, notes: "Both hypothyroidism and hyperthyroidism can present with fatigue or changes in energy levels, which can impact athletic performance and endurance."[13] Understanding these effects helps athletes address potential issues early. Signs to Watch For Athletes should pay attention to these symptoms for thyroid imbalances: Hyperthyroidism (Overactive Thyroid) Unexplained weight loss with increased appetite Muscle weakness Rapid heart rate Excessive sweating Sleep problems Hypothyroidism (Underactive Thyroid) Persistent fatigue Trouble building or maintaining muscle Slower recovery from workouts Joint and muscle pain Unexplained weight gain If you notice these signs, testing is critical to confirm and address the issue. Testing Tips for Athletes Studies show that 57–90% of hypothyroid patients have elevated creatine kinase (CK) levels [12]. To ensure accurate results: Schedule tests in the early morning. Keep follow-up tests at consistent times. Let your provider know about any medications, supplements, or thyroid concerns. Athletes using androgenic anabolic steroids should be particularly cautious, as these substances can disrupt thyroid function [12]. Supporting Thyroid Health Regular testing can guide adjustments to training and recovery routines. Thyroid hormones are important for muscle function, especially in promoting faster muscle fiber types in muscles with a higher proportion of slow fibers [14]. To maintain thyroid health, athletes should focus on: Prioritizing quality sleep Managing training-related stress Following a well-rounded diet Monitoring thyroid levels regularly Taking care of thyroid health ensures you’re getting the most out of your training efforts. sbb-itb-2f7d8a0 5. IGF-1 Blood Test The IGF-1 blood test measures muscle growth, recovery, and tissue development influenced by growth hormone activity. IGF-1 works alongside growth hormone to support tissue building and muscle protein synthesis. Understanding IGF-1's Role About 75% of IGF-1 is produced in the liver [18]. Unlike growth hormone, which fluctuates throughout the day, IGF-1 levels remain steady, making it a reliable marker for assessing average growth hormone activity [16][17]. IGF-1 Function Impact on Performance Muscle Growth Promotes protein synthesis and muscle development Recovery Activates satellite cells to aid muscle repair Metabolism Improves insulin sensitivity and glucose uptake Bone Health Contributes to bone growth and strength Testing Considerations The United States Anti-Doping Agency (USADA) highlights the importance of medical oversight when it comes to IGF-1: "IGF-1 is produced in response to physiological or pharmaceutical growth hormone (GH), and is responsible for many of the anabolic effects of GH. It can enhance the production of lean muscle as well as aid in recovery time, but when used without medical necessity, exogenous IGF-1 can cause serious harm." [15] Supporting IGF-1 Naturally Boost IGF-1 levels through a diet rich in protein and selenium, paired with progressive strength training. Age-Related Trends IGF-1 levels naturally rise during childhood, peak during puberty, and decline with age. Always refer to age-specific ranges for accurate interpretation. Performance Benefits IGF-1 can improve athletic performance in several ways: Stimulating satellite cells to repair and rebuild muscle fibers Activating the mTOR pathway to increase protein synthesis Reducing protein breakdown by inhibiting FoxO-1 Enhancing insulin sensitivity for better glucose uptake [18] Regular IGF-1 testing can help fine-tune your training plan while ensuring compliance with anti-doping regulations. 6. Estradiol Measurement Estradiol testing is valuable for both male and female athletes aiming to improve their performance. This hormone plays a role in muscle growth, recovery, bone strength, and overall hormone balance, making it an important factor in crafting an effective performance strategy. Normal Reference Ranges Understanding baseline estradiol levels is essential for accurate analysis: Gender/Status Normal Range (pg/mL) Male 10–50 Female (Premenopausal) 30–400 Female (Postmenopausal) 0–30 Impact on Athletic Performance Balanced estradiol levels contribute to muscle strength, recovery, bone density, fat distribution, and mood stability. Studies indicate that estradiol can enhance muscle recovery and strength [20]. Testing Considerations Accurate estradiol measurements require sensitive testing methods. Opt for FDA-approved techniques to ensure reliable results. Warning Signs In men, estradiol levels above 40 pg/mL may indicate potential performance issues. Low estradiol levels can result in: Reduced bone density Slower muscle recovery Sexual health challenges Increased fat accumulation [19] Identifying these imbalances early helps fine-tune training and overall health strategies. Optimization Strategies To maintain healthy estradiol levels: Engage in strength training and maintain a balanced body composition Follow an anti-inflammatory diet rich in vitamin D and calcium Manage stress effectively and prioritize good sleep For athletes using performance-enhancing substances, avoid excessive estradiol suppression, as it can cause negative health effects [19]. Making informed adjustments based on estradiol levels can lead to better training outcomes. Regular Monitoring Incorporate estradiol testing into your routine hormone panel checks to refine your performance strategy and identify any additional markers for optimization. 7. DHEA Blood Test The DHEA blood test is a useful tool for monitoring hormonal health. DHEA, a steroid hormone produced mainly by the adrenal glands, plays a key role in the production of testosterone and estrogen. Understanding DHEA Levels DHEA-S (sulfate) levels naturally vary based on age and gender. They typically peak during puberty and slowly decline as you age. Since lab reference ranges can differ, it's important to review your results with a healthcare provider. How DHEA Affects Performance DHEA can influence athletic performance in several ways: It supports muscle growth when combined with resistance training. It helps reduce muscle damage and soreness with doses of about 100 mg daily. It aids in maintaining hormonal balance as a precursor to testosterone and estrogen [22] [23]. When Should You Test? Athletes might consider testing if they notice signs like unexplained fatigue, reduced performance, difficulty building or maintaining muscle, slow recovery, or other hormonal imbalance symptoms. Women experiencing menstrual irregularities or signs of virilization might also benefit from testing. Identifying these issues early can help you address potential setbacks. What High or Low Levels Mean High DHEA-S levels: Could indicate conditions like congenital adrenal hyperplasia, adrenal tumors, or polycystic ovary syndrome (PCOS). Low DHEA-S levels: May suggest adrenal insufficiency or hypopituitarism. They might also reflect the natural decline in hormone production with age. Tips for Maintaining Healthy DHEA Levels Athletes looking to maintain or improve their DHEA levels can take these steps: Use trusted providers like Discounted Labs for hormone panels at over 2,200 U.S. locations. Get regular tests every three to six months to track changes. Prioritize quality sleep, manage stress, and follow a balanced diet to support overall hormonal health. Key Points to Remember DHEA supplements are banned by the World Anti-Doping Agency (WADA) [21]. Research shows that plasma DHEA-S levels can drop by up to 80% between ages 25 and 75 [22]. Regular blood tests and professional guidance are essential for keeping your hormones in check and staying on top of your performance. 8. LH and FSH Testing LH (Luteinizing Hormone) and FSH (Follicle-Stimulating Hormone) tests offer insight into hormonal balance and endocrine health, especially for athletes and bodybuilders. These hormones, produced by the pituitary gland, play key roles in reproductive health. What Do LH and FSH Do? In men, LH stimulates the Leydig cells in the testes to produce testosterone, which is crucial for sperm production. FSH, on the other hand, supports the development of healthy sperm. For women, LH is involved in triggering ovulation and regulating the menstrual cycle, while FSH helps ovarian follicles grow and mature. Normal LH levels in men aged 20 to 70 usually range from 0.7 to 7.9 IU/L [25]. These functions highlight why testing is important, particularly when performance or recovery issues arise. When Should You Get Tested? Consider testing LH and FSH levels if you notice: Unexplained fatigue or a drop in performance Loss of muscle mass or strength Low sex drive Irregular menstrual cycles (for female athletes) Struggles with workout recovery What Do Test Results Mean? Elevated levels may indicate ovarian or testicular failure, while low levels could point to problems with the pituitary gland or hypothalamus. These imbalances can result from chronic stress, overtraining, poor recovery, or nutritional gaps [26]. Supporting Healthy Hormone Levels To maintain balanced LH and FSH levels, athletes can: Eat a well-rounded diet Adjust training intensity as needed Prioritize recovery time Address insulin resistance through dietary changes [24] Consider a Mediterranean-style diet to support overall hormonal health The Importance of Regular Monitoring Routine testing helps athletes keep track of their hormone levels and address imbalances early. Consulting healthcare professionals ensures proper interpretation of results and helps guide effective interventions. This is particularly important for competitive athletes, as prolonged training stress can disrupt the hypothalamus and reduce LH production [24]. Conclusion Regular hormone testing plays a crucial role for athletes who want to fine-tune their performance. Research shows that up to 85% of people may deal with hormonal imbalances [27], making these tests an important tool for staying in top physical shape. For instance, a testosterone-to-cortisol ratio drop of 30% or more can signal poor recovery and overtraining [28]. Experts like Dr. Zane Hauck and Dr. Mini Sara Cherian highlight how blood tests help athletes adjust workload, recovery, and overall health [1][29]. These insights ensure training programs are based on solid data. To get the most out of hormone testing, athletes should keep these factors in mind: Timing Matters: Tests should account for variables like time of day, hydration, training intensity, and - for women - the menstrual cycle [30]. Diet Adjustments: Results may suggest dietary changes. For example, consuming up to 2 grams of protein per kilogram of body weight and maintaining moderate fat intake can help keep hormone levels in check [30]. Recovery Insights: Monitoring hormones can guide recovery strategies and help avoid overtraining [30]. From testosterone to LH/FSH, each test adds to a comprehensive view of hormonal health. Fortunately, FDA-approved labs across the country now widely offer these tests, making it easier than ever for athletes to maintain optimal hormonal health.

DHEA Levels: Do You Need to Take a Supplement? The dehydroepiandrosterone sulfate (DHEA-S) test checks how much DHEA-S is in the blood. The adrenal gland produces the hormone DHEA-S. It is a building block for androgens and estrogens. The test is generally done to check how well the adrenal glands are working and to look into conditions that might cause hormone production to be off. DHEA-S test, also known as the test DHEA sulfate, can help figure out what’s causing irregular periods, infertility, and a low libido. It is also used to find out if someone has a growth in their adrenal gland, congenital adrenal hyperplasia, or polycystic ovary syndrome. People on long-term glucocorticoid medicine can also use the test to check how well their adrenal glands are working. It is an important test for people who think their hormones might be out of order. What is DHEA? The adrenal glands also produce dehydroepiandrosterone (DHEA), the most abundant hormone found in the blood stream. Your adrenal glands and, to a lesser extent, your ovaries and testes produce the hormone known as DHEA. DHEA is changed into DHEA-S in your adrenal glands and liver. The body uses DHEA as the starting material for producing the sex hormones testosterone and estrogen. However, DHEA supplementation studies have shown that it only increases testosterone in women. The production of DHEA diminishes in most people after age 40. DHEA levels typically decrease with age in both men and women, highlighting its significance in hormone testing and the evaluation of conditions affecting adrenal function and hormonal balance. In people aged 70 years, DHEA levels will be approximately 30 percent lower than what they were at age 25. Low blood levels of DHEA have been associated with many degenerative conditions, making it a popular supplement for those undergoing in-vitro fertilization (IVF) treatments.   Understanding DHEA and Its Role in the Body DHEA is a hormone produced by the adrenal glands, which are small glands located on top of each kidney. These glands are responsible for producing most of the body’s DHEA, with smaller amounts being produced by the testicles in men and ovaries in women. DHEA plays a crucial role in the production of sex hormones, including testosterone and estrogen, which are essential for the development of male and female sex characteristics. As we age, DHEA levels naturally decline, with the highest levels typically occurring during puberty. This decline can lead to a range of symptoms, including decreased libido, fatigue, and weight gain. However, it’s important to note that DHEA supplements are not recommended as a way to prevent aging-related conditions, as there is no reliable evidence to support their effectiveness. While some people may seek out DHEA supplements to counteract these symptoms, it’s crucial to approach supplementation with caution and under the guidance of a healthcare professional. DHEA is a hormone produced by the adrenal glands DHEA plays a crucial role in the production of sex hormones DHEA levels naturally decline with age The Importance of DHEA Sulfate (DHEAS) DHEAS is the most abundant form of DHEA in the body, accounting for approximately 90% of the total DHEA present. Produced by the adrenal glands, DHEAS is converted into DHEA in the body. The DHEA sulfate test measures the levels of DHEAS in the blood, which can help diagnose adrenal disorders and evaluate adrenal function. DHEAS plays a crucial role in regulating the reproductive system. Abnormal levels can lead to a range of symptoms, including excess hair growth, male pattern baldness, and deepening of the voice in women. In men, high levels of DHEAS can cause early puberty, while low levels can lead to erectile dysfunction and decreased libido. In women, high levels of DHEAS can cause polycystic ovary syndrome (PCOS), a condition characterized by irregular menstrual periods, excess hair growth, and infertility. Low levels of DHEAS can lead to adrenal insufficiency, a condition where the adrenal glands do not produce enough hormones. The DHEA sulfate test is typically ordered by a healthcare provider if symptoms indicate an adrenal disorder or adrenal tumor. The test involves a blood sample, which may cause moderate pain, a prick or sting, and possibly some throbbing or bruising after the needle is inserted. The test is usually performed at a doctor’s office or another medical setting, and the results are typically available within a few business days. Normal blood levels of DHEAS can differ by sex and age, with typical normal ranges for females being 20-150 mcg/dL and for males being 30-450 mcg/dL. Abnormal levels of DHEAS can indicate a range of conditions, including adrenal gland disorders, pituitary gland disorders, and congenital adrenal hyperplasia. In conclusion, DHEA and DHEAS play crucial roles in the body, and abnormal levels can lead to a range of symptoms and conditions. The DHEA sulfate test is an essential tool for diagnosing adrenal disorders and evaluating adrenal function. If you’re experiencing symptoms related to adrenal disorders, it’s essential to consult with a healthcare provider to determine the best course of action. DHEAS is the most abundant form of DHEA in the body Who Can Benefit from Taking DHEA Supplements? Some controversial and non-conclusive studies have shown that people with immune deficiencies and fatigue may benefit from supplementation with this hormone. It is also believed to help correct some adrenal problems, such as changes in blood pressure, caused by conditions such as adrenal insufficiency. It is still available over-the-counter in the United States. Due to a recent congressional bill classifying it as a performance-enhancing steroid (despite the fact that no studies have demonstrated that it has such an effect), this might soon change. One study showed that women with the correct levels of DHEA can convert it into testosterone as their body needs it, while men do not benefit to the same degree. You need a blood test to know if you have low DHEA-S since most of the DHEA converts into this sulfated form. Common doses for women are 5 to 30 mg a day, while men tend to benefit from 25–100 mg per day (to bring low levels of DHEA-S to normal) DHEAS was the only hormone significantly negatively correlated to the prevalence of erectile dysfunction among 17 investigated hormones, including testosterone and estradiol, in the large and long-term Massachusetts Male Aging Study. In addition, a study done by Dr. Basar et al., which included 348 male patients, reported that DHEAS and free testosterone levels were significantly lower in men with sexual dysfunction. However, evidence of the positive effects of DHEA supplementation on improving sexual function in men is unconvincing, scanty, and conflicting. Only 4 placebo-controlled studies have been performed to investigate the effect of supplementing DHEA on improving libido in men. Unfortunately, the data from these studies did not show any difference in sexual desire in men. The limited effect of DHEA on male sexual function is not surprising. In fact, the specific DHEA contribution to the overall circulating testosterone level in men is marginal, if not negligible. A double-blind, placebo-controlled study was done on male and female patients with low thyroid function (hypopituitary) who were given growth hormone (GH) along with 50 mg of DHEA. When DHEA was replaced in female patients, the dose of GH dropped by 14.6 +/- 20% while serum IGF-I stayed the same (P < 0.05). This was maintained for 12 months, and there was a significant fall in serum IGF-I two months after the withdrawal of DHEA. There was no change in the male group. Do not use DHEA supplements unless your blood levels of DHEA-S are low. If low, start at a low dose and get your DHEA-S tested again after a month. Men who use DHEA supplements may have problems with higher estrogen levels since this hormone can also be metabolized into estradiol. This could result in gynecomastia and water retention. If you start taking DHEA, have your blood levels checked to make sure they are not above normal. Additionally, individuals with a history of hormone-sensitive cancers, such as breast or prostate cancer, should consult with their doctor before taking a DHEA supplement. There are many claims about DHEA being an anti-aging and anti-cancer cure, but none of these claims have been substantiated with strong data. How Do You Know Your DHEA Blood Level with a DHEA Sulfate Test? The standard blood test to evaluate DHEA status is one that measures DHEA sulfate levels (dehydroepiandrosterone sulfate, or DHEA-S). DHEA-S is calculated in micrograms per deciliter (µg/dL) of blood. A DHEA-S blood test may be taken three to six weeks after initiating DHEA to help determine optimal dosing. DHEA testing may save you money if it shows you can take less DHEA to maintain youthful DHEA serum levels. Potential Benefits of DHEA Supplementation Low DHEA and Adrenal Insufficiency Adrenal insufficiency is a condition in which the adrenal glands do not produce enough of the hormone DHEA. In such cases, doctors may prescribe DHEA supplements to help alleviate symptoms and improve quality of life. The National Collegiate Athletic Association has banned the supplement, but studies have shown that it may be useful in treating lupus and adrenal insufficiency (Philadelphia, PA: Elsevier). However, further research is still needed to determine its effectiveness in treating these conditions. DHEA and Depression DHEA (dehydroepiandrosterone) supplements have been studied for their potential to alleviate depressive symptoms. The test DHEA sulfate can help diagnose adrenal disorders that may contribute to depressive symptoms. Studies have found that DHEA-S levels are associated with depressive symptoms in women in the late reproductive years. A systematic review and meta-analysis of randomized controlled trials showed that DHEA may be effective in treating depressive symptoms in various psychiatric and medical illnesses. However, further research is needed to fully understand the effects of DHEA on depression and its potential as a treatment option, making DHEA treatment a potential option for those struggling with depressive symptoms. DHEA in Elderly Men A DHEA supplement has been found to be beneficial for elderly men. Studies have shown that elevated serum dehydroepiandrosterone sulphate levels correlate with an increased risk for metabolic syndrome in elderly men. DHEA supplements can also produce small decreases in fat mass in elderly men, although more research is needed to confirm this finding. Additionally, taking DHEA supplements may also have an effect on body weight and fat burning, but the evidence is unclear. It is important to consult a healthcare professional before taking any DHEA supplements, especially for elderly men with pre-existing medical conditions or those taking other medications. DHEA supplements have been suggested to slow down the aging process by maintaining DHEA levels in the body. Although some small studies have reported positive anti-aging effects from the use of DHEA supplements, others have not shown any effect. According to the Natural Medicines Comprehensive Database, there is no conclusive evidence that DHEA supplements affect the aging process. DHEA is a precursor for the production of estrogens and androgens, and its production decreases with the aging process, which makes it a controversial topic among researchers regarding its use in postmenopausal women. DHEA and Bone Density A DHEA supplement has been studied for its potential to improve bone mineral density in older women. Studies have produced mixed results, but some suggest that DHEA may increase bone mineral density in the hip and thigh bones of females. This effect seems to increase with higher doses of the supplement. DHEA can be expressed via sex steroid receptors and androgen and estrogen receptors and plays a role in bone cell proliferation and differentiation. The activation of androgen receptors can stimulate bone cell growth, which may contribute to improvements in mineral density. DHEA and Bodybuilding DHEA often gets marketed as a “muscle builder” to men. As a muscle-building supplement in young, healthy men, DHEA is essentially worthless, and high intakes may in fact be counterproductive to gaining muscle as high doses also cause an increase in estrogen and the effects on testosterone are minimal. Studies have been conflicting in this area at best, and most “real world” users report no improvements in strength, muscle mass, etc. from using DHEA, with little evidence to support its effectiveness. As a supplement that can improve mood, libido, memory, and possibly alter body composition (i.e., increase muscle, improve bone density, and reduce body fat), DHEA appears to be an option to explore for women. Most of the research has been done in DHEA-deficient populations, but data and real-world experience suggest it's also beneficial to women who are not medically deficient in this hormone, particularly in improving sex drive. Although the benefits of this hormone to women come predominately from its conversion to testosterone, it also appears that some of the effects may be due to other mechanisms. DHEA Potential Interactions Yes, it is important to be aware of potential interactions with other medications or supplements when taking a DHEA supplement. DHEA can interact with several types of medications like blood thinners, insulin, and corticosteroids. It may also affect the effectiveness of certain herbal supplements, like ginkgo biloba and saw palmetto. People with liver problems should also avoid taking DHEA, as it is metabolized in the liver. It is advisable to consult with a healthcare professional before starting any new supplement regimen to ensure there are no adverse effects or interactions with existing medications or supplements. How Long Does It Take for DHEA to Work? The length of time it takes to see results from taking a DHEA supplement can vary depending on multiple factors. Some people may notice an improvement in their symptoms within just a few days, while others may need to take the supplement for several weeks or even months before seeing any noticeable changes. It is important to speak with a healthcare professional before starting any new supplement regimen to determine the appropriate dosage and monitor any potential side effects. Additionally, it's important to keep in mind that DHEA supplements are not appropriate for everyone and that those who are pregnant, nursing, or have certain medical conditions should avoid taking them. DHEA Dosage The recommended dosage for a DHEA supplement varies depending on age, gender, and health conditions. Generally, the recommended dosage for men is 50–100 mg per day, while women are advised to take 25–50 mg per day. However, it is important to consult with a healthcare provider before starting any supplement regimen. Additionally, it is recommended to take DHEA supplements in the morning as the body naturally produces more DHEA during this time. It is also suggested to cycle DHEA use, taking it for three weeks and then pausing for one week before resuming. different individuals. Its role in supporting adrenal function, potentially aiding in conditions like adrenal insufficiency and depression, and influencing bone density and sexual health, offers hope for specific groups, especially postmenopausal women and the elderly. However, it's crucial to approach DHEA supplementation with caution and informed understanding. Men, particularly, may find limited benefits and should be wary of potential side effects like increased estrogen levels. Conclusion Before considering DHEA supplements, it's essential to get your DHEA-S levels tested. This is where DiscountedLabs.com can be an invaluable resource, offering affordable and convenient blood tests without the need for a doctor's visit in several U.S. states. Understanding your DHEA-S levels is the first step in determining whether supplementation is right for you. Remember, while DHEA has potential benefits, it's not a one-size-fits-all solution. Consult with healthcare professionals, consider potential interactions with other medications or supplements, and monitor your body's response to supplementation. As we continue to explore the benefits and limitations of DHEA supplements, it's essential to make informed, health-focused decisions, aided by reliable testing and professional advice. Turn to DiscountedLabs.com for your testing requirements if you're thinking about taking DHEA supplements so that you can make informed health decisions.

Estrogen in Men: Myths and Realities of High Estradiol In men, the liver, fat cells, and other cells aromatize testosterone to produce estradiol, which is a hormone that is more prevalent in women than in men. Estradiol is responsible for healthy bone density and cholesterol, but its role in men’s sex drive, body composition, and other variables is a source of great debate. It is crucial to understand that estrogen plays a significant role in male reproductive health, particularly in the processes of sperm production and maturation within the testes. Many men on testosterone replacement therapy (TRT) initially fear high estradiol levels since they fear it causes water retention and gynecomastia. However, it is important to note that fat cells play a significant role in the production of aromatase, which can lead to higher levels of estradiol in the body. Below, we will discuss why most men on TRT do not have to be overly concerned about the estradiol lab ranges that are ill-fitted for men on TRT, as the ranges of LabCorp and Quest were not derived from a dataset of men on TRT who usually have higher total testosterone blood levels. What is Estradiol and Why is it Important for Men's Health? Estradiol is a type of estrogen hormone that plays a crucial role in men’s health. Often referred to as a 'female sex hormone,' estradiol also plays a crucial role in male health. It helps regulate bone density, cognitive function, libido, and mood. However, high levels of estradiol in men can lead to negative effects like decreased muscle mass, increased body fat, and hormonal imbalances. Men’s liver, fat, and other cells aromatize testosterone to produce estradiol, a hormone that is more prevalent in women than in men. Estradiol is responsible for healthy bone density and cholesterol, but its role in men’s sex drive, body composition, and other variables is a source of great debate. Many men on testosterone replacement therapy (TRT) initially fear high levels of estradiol since they fear it causes water retention and gynecomastia. We will talk about why most men on TRT do not need to worry too much about the estradiol lab ranges that do not work well for them because LabCorp and Quest did not get their ranges from a group of men on TRT who usually have higher total testosterone blood levels. High levels of estradiol in men are associated with abdominal obesity and an increased risk of cardiovascular disease. What is High Estradiol?: Predicted Blood Levels in Young and Older Men on TRT Transcript of video below: There needs to be more clarity on the subject since LabCorp and Quest have very narrow, sensitive estradiol test ranges. Those estradiol test ranges were primarily derived from men not on testosterone replacement therapy. Men on TRT tend to have higher testosterone levels than men not on testosterone replacement. So, believe it or not, a paper published many years ago predicts estradiol and DHT levels in men given different doses of testosterone. This study examined what happens to blood levels of testosterone, estradiol, and DHT when injecting different testosterone doses in young and older men. This study was very nicely done at the Boston University School of Medicine by well-known testosterone researchers. Dr. Basin is one of them and has done excellent work for the last 30 years. Video: How to Predict High Estradiol in Men Testosterone is the precursor hormone for estradiol. The aromatization of testosterone in the liver, fat, and other cells, including the testes, results in estradiol, a hormone that is more prevalent in women than men. Nature created it for a reason. It is responsible for healthy bone density and cholesterol, but its role in men's sex drive, body composition, and other variables is a source of great debate. Many anti-aging or men's health clinics prescribe aromatase inhibitors (AIs) to men who start testosterone replacement therapy (TRT). Higher estradiol blood levels in the presence of low testosterone can cause breast tissue growth (gynecomastia) in some men and possibly other issues. Some people speculate that high estradiol levels can also lead to difficulty achieving or maintaining an erection, but no scientific papers have been published on this subject. Since higher testosterone blood levels can result in higher estradiol levels in men, the belief is that using an AI will prevent breast tissue growth and erectile dysfunction by lowering any potential increase in estradiol. However, we have no data on how high is too high when it comes to this hormone in men using testosterone therapy. Emerging data show that low testosterone-to-estradiol ratios may correlate more closely to infertility, gynecomastia, and erectile problems than high estradiol levels alone. The truth about these speculations is starting to emerge, but we still need more data to say what the upper value of the optimal range of estradiol in men is. We have a lot of evidence about the lower side of the optimal range since it has been found that estradiol blood levels below 10–20 pg/mL can increase bone loss in men. A recently published study also nicely demonstrated that low estradiol could be associated with higher fat mass and lower sexual function in men. So, be careful when a clinic wants to put you on an aromatase inhibitor without first justifying its use. Increased Aromatase Activity and the Role of Aromatase Inhibitors in Men Aromatase is an enzyme that converts testosterone to estradiol, a form of estrogen. Germ cells, along with Leydig cells, are significant sources of estrogen production in the testes. In men, aromatase activity is typically low, but certain conditions can increase it, a process known as aromatase overexpression. This can lead to higher levels of estradiol in the body, which can have negative effects like decreased libido and muscle mass in the adult male. However, some studies suggest that moderate increases in estradiol may have cardiovascular benefits. One condition that can increase aromatase activity and therefore estradiol levels is aromatase excess syndrome, a genetic condition that affects both males and females. It’s important for men to maintain healthy levels of both testosterone and estradiol, and understanding the role of the aromatase enzyme, especially in conditions like aromatase excess syndrome, is crucial in managing estradiol levels. Estradiol in Men After Different Testosterone Doses: Study Details This study's findings were published in the Journal of Clinical Endocrinology and Metabolism in 2010. The fantastic thing is that nobody has reviewed it, even though it's probably the most important paper on what happens to estradiol and DHT in men on TRT. The study enrolled 51 young men aged 19 to 35 and 52 older men aged 59 to 75. These men were given a gonadotropin-releasing hormone agonist to shut down their gonadotropins, LH and FSH, testosterone, estradiol, and DHT. So, these were courageous volunteers who were willing to have their hormones wholly shut down. So, why did they do this? They did it because the researcher wanted to start from zero regarding hormones. So, those men were given injections of different doses of testosterone enanthate, 25, 50, 125, 300, and up to 600 milligrams a week for five months. And the researchers measured the testosterone, estradiol, and DHT blood levels. Unfortunately, they used the old estradiol test based on immunoassay. This estradiol test may not be the best for accurate estradiol testing. The use of an ultra-sensitive estradiol test is more accurate since it has no interference from CRP or inflammatory markers Usually, the sensitive estradiol is 20% lower than the estradiol levels measured by the old test. Let's assume that most of these men did not have inflammation. Here are their baseline characteristics. Interestingly, they were even exposed to such high doses of testosterone. So, after a four-week controlled period, they were given a testosterone blocker, the gonadotropin-releasing hormone agonist that shuts down gonadotropins. This drug is used to treat prostate cancer. They were randomized to receive weekly injections of testosterone enanthate for 20 weeks. The researchers found an issue with the higher testosterone dose in older men, with a few more side effects. They stopped a few men from continuing with the 600 milligrams of testosterone weekly. And then the randomization was limited to 25, 50, 125, and 300 milligrams of testosterone injections weekly. I've warned people not to use high testosterone doses, especially older people with comorbidities and heart problems. Increased blood pressure and tachycardia are some of the side effects listed in the study paper. So, what you see here are serum estradiol E2:T ratios. We talk about ratios on ExcelMale.com. Here are the opposite DHT and T ratios from what I typically talk about when dividing T by E2. And the black bars are younger men, and the white bars are older men. So, this is total estradiol, free estradiol, total DHT, and free DHT. And when we talk about free, what does that mean? It is the unbound estradiol and unbound DHT that aren't bound by sex hormone-binding globulin. And those two free estradiol and free DHT tests are rarely tested in clinics. DiscountedLabs.com does provide a free estradiol test for those who are interested. But since there are no studies about free estradiol blood levels in men, it's hard to say what a good free estradiol level is. High Estradiol in Men on TRT Most men on TRT initially fear high estradiol since they fear it causes water retention and gynecomastia. While high estradiol levels in men can cause gynecomastia, in women, similar hormonal imbalances are linked to an increased risk of breast cancer. They feel puffy; they may have more sensitive nipples. I will discuss this in another video because those symptoms are usually not connected to high estradiol per se when men have moderate to high testosterone levels. The most common cause of edema, or the problem of holding onto water weight, is a slowdown in sodium metabolism in the kidneys brought on by testosterone and androgens. Sodium (salt) retention happens in the first few weeks, especially with higher TRT doses in older men. The stimulating effects of testosterone may be to blame for the sensitive nipple issue, which typically does not cause gynecomastia. However, it is important to note that symptoms of high estrogen in men can also include swelling or enlargement of breast tissue, erectile dysfunction, infertility, depression, and delayed puberty. So, as you can tell, total E2, free E estradiol, and DHT increase with increasing testosterone doses, and this increase is much more pronounced in older men. It’s good to mention that these volunteers were not fat men. The increased fat mass has been linked to increased estradiol levels, which are often measured through body mass index (BMI). These are men with a BMI of around 26, which is not a high number. But anyway, we do see an increase. And older men, in white, tend to have a higher estradiol increase. DHT is the same thing. Although the differences were not as noted between young and old, you can tell here the free DHT. When you divide estradiol into testosterone, that’s when you see a decrease. Estradiol increases to a higher degree than testosterone, so the ratio of E2 divided by T decreases. The total DHT to T ratio is the same; it decreases as we increase the testosterone dose, but not as fast as the estradiol. It is essential to mention that 0.3% to 0.4% of testosterone is aromatized into estradiol. That’s a very tiny amount; that’s 0.4%. The conversion of testosterone to DHT by 5 alpha-reductase is around 10%. That’s why you see the scales a little more prominent on the DHT side. What to Know About Estrogen in Men Estrogen is commonly associated with women, but men also have this hormone in their bodies. The testes and adrenal glands are primarily responsible for producing estrogen in a male body. Estradiol is a type of estrogen that plays an important role in maintaining bone health, regulating cholesterol levels, and supporting brain function. Low levels of estradiol in men can contribute to a variety of health issues, such as decreased libido, erectile dysfunction, and osteoporosis. It's important for men to understand their hormonal balance, including their levels of estradiol, and work with a healthcare provider to address any imbalances or concerns related to erectile function and hormone balance. Buy an affordable, ultrasensitive estradiol test:   Understanding Androgens and Estrogens Estradiol is a type of estrogen that is found in both men and women. While it is often associated with female reproductive health, estradiol plays an important role in male health as well. Estrogens influence male reproductive function by maintaining a hormonal balance between estrogens and androgens, which is crucial for male fertility. In fact, it is responsible for regulating bone density, cholesterol levels, and even mood. When there is high estradiol in men, it can lead to a variety of health problems. Understanding the balance between androgens (male hormones) and estrogens (female hormones) is crucial for sexual development and maintaining optimal health for both men and women, especially in relation to the menstrual cycle. Risk Factors of Having High Estradiol in Men Estrogen is often associated with females, but it also plays a crucial role in men's health. High or low levels of estrogen in males can have negative impacts on their overall health. Men who have higher than normal levels of estrogen, also known as estrogen, may experience breast enlargement, erectile dysfunction, infertility, and other issues. On the other hand, men with lower than normal levels of estrogen may experience decreased bone density, muscle mass, and sex drive. It is important for men to maintain balanced estrogen levels through proper diet, exercise, and medical treatment if necessary. However, it is important to note that too much estrogen, also known as high levels of estrogen, can also be harmful to men's health, and it is important for individuals to monitor their estrogen levels and consult with a doctor if they have any concerns. How Men Can Keep Their Estrogen Levels Balanced Estrogen is typically associated with women, but men also have this hormone in their bodies. Estradiol is the most potent form of estrogen in men and plays a crucial role in maintaining bone density, sperm production, and sexual function. However, too much or too little estradiol can cause various health problems. Men can keep their estrogen levels balanced by maintaining a healthy weight, avoiding exposure to environmental toxins, managing stress levels, and getting enough sleep. A balanced diet rich in fiber and phytoestrogens, along with proper monitoring and control through hormone replacement therapy, may also help regulate estrogen levels in men, ensuring healthy sperm production. Normal Estrogen Levels in Men Estrogen is often thought of as a female hormone. However, it's also present in men, just at lower levels. One type of estrogen found in men is estradiol. Normal levels of estradiol in men vary depending on age and other factors. In general, levels range from 10 to 60 pg/mL. If levels are too high or too low, it can lead to health issues such as osteoporosis, sexual dysfunction, and mood changes. Men should discuss their estrogen levels with their healthcare provider to ensure they are within a healthy range for their age and overall health status. This includes monitoring the amount of estrogen in their body, as there are two main types of estrogen in men: estrone and estradiol, and an imbalance of these hormones can have negative effects on their health. Gynecomastia and High Estradiol in Men Gynecomastia is a condition that causes men to develop breast tissue. Studies on male mice, such as αERKO and ArKO models, highlight the effects of estrogen deficiencies on sexual behavior and fertility. One of the underlying causes of gynecomastia is an imbalance of hormones, including estradiol. Estradiol is a form of estrogen that is typically found at higher levels in women. However, men also have small amounts of estradiol in their bodies. When the balance between estradiol and testosterone is disrupted, it can lead to the development of breast tissue in men. Treatment for gynecomastia may involve addressing the hormonal imbalance through medication or surgery, depending on the severity of the condition. You can buy a gynecomastia lab test panel on Discounted Labs. Low Estradiol Can Cause Loss of Libido and Erectile Dysfunction One of the significant impacts of estradiol deficiency in men is the loss of libido. Low levels of estradiol can lead to decreased sex drive, which can cause problems in relationships and affect overall quality of life. However, it's essential to note that there are other factors that can impact libido as well, such as stress, depression, low testosterone levels, and a lack of sexual activity. If you're experiencing a loss of libido, it's important to talk to your doctor to determine the underlying cause and discuss possible treatment options. A Study Helps to Predict Normal Estradiol and DHT Test Levels in Men on TRT Most men on TRT don't have to be so concerned about the LabCorp or Quest estradiol ranges that usually scare people because they're always high. And there is statistical significance in the baseline values of young and older men. DHT increases were higher in older men. In younger men, usually, that's also connected to total testosterone and is also related to higher libido. Older men had lower DHT, which was also linked to their lower testosterone. Sex hormone-binding globulin (SHBG) is also higher in older men. The researchers in this study came up with a model with factors to predict the estradiol and DHT response curves. They provided two equations for young men (estradiol and DHT) and two for older men. Using those equations, you can roughly estimate the predicted estradiol and DHT levels for different testosterone blood levels. These equations enable us to see what is considered a “normal” estradiol level instead of using estradiol lab ranges that are ill-fitted for men on TRT. As previously mentioned, the estradiol ranges of LabCorp and Quest were not derived from a dataset of men on TRT who usually have total testosterone blood levels over 600 ng/dL (many men on TRT have T levels of 1000 ng/dL or more!). The Importance of Preserving Proper Levels of Estradiol in Men Our bodies transform 0.4% of testosterone into estradiol to balance the potentially negative effects of testosterone alone on lipids and other variables. If you have “high” testosterone, your estradiol should be “high.” Treating that estradiol with an aromatase inhibitor may not be needed and can potentially crash your estradiol level. Estradiol has essential roles in men, including the regulation of hormone levels. Estradiol comes in to protect us from higher testosterone and helps improve lipids, HDL, and endothelial function. Women tend to live longer than men because they have more estrogen to protect them against the cardiovascular risks we are all exposed to. So, don't freak out when you see the 60s, even in the 70s, depending on how high your testosterone is. And the only problem we're having in this field is that we still need to do a study that goes after symptomology depending on estradiol blood levels when we control testosterone. We know that estradiol levels under 15 picograms per milliliter cause problems with bone density and even fat gain. Many members of ExcelMale.com say that their penile sensitivity decreases when they have low estradiol. We do not know what high estradiol in men means in relation to estradiol blood levels in relation to testosterone. Can high estradiol in men on TRT with relatively high testosterone blood levels cause issues? Is there a proper and healthy testosterone-to-estradiol ratio?. If somebody is, let's say, at 1,275 ng/dL of testosterone and 64 pg/mL of estradiol, is there any consequence to that? We don't know. And the problem I'm seeing is that most of you guys are assuming too much; you're assuming that because you're holding water or you have sensitive nipples, you have high estradiol. And you start treating with an AI without even testing your blood levels of estradiol, especially using the sensitive assay. That concerns me because once you start treating with an AI, you can crash your estradiol. “Crashed estradiol” has become one of the most significant traffic source keywords for ExcelMale because people are experiencing that more and more. I hope you enjoyed the presentation. Please remember to subscribe to the ExcelMale forum and the ExcelMale YouTube channel, and make sure that you click on that little bell that will tell you when I upload new videos. Thanks a lot, and stay safe. Estrogen Dominance and Hormonal Imbalance Estrogen dominance occurs when there is an imbalance between estrogen and testosterone levels in the body. This hormonal imbalance can lead to a range of symptoms, including weight gain, mood swings, and decreased libido. Men experiencing estrogen dominance may notice an increase in body fat, particularly around the abdomen, and may struggle with emotional changes such as irritability or depression. Additionally, estrogen dominance can negatively impact overall health by contributing to conditions like insulin resistance and cardiovascular issues. Maintaining a proper balance between estrogen and testosterone is crucial for optimal health and well-being. Exposure to Endocrine Disruptors and Environmental Toxins Endocrine disruptors and environmental toxins can significantly impact estrogen levels and overall health. These substances, found in everyday items like plastics, pesticides, and personal care products, can mimic the effects of estrogen in the body, leading to hormonal imbalances. When these toxins enter the body, they can bind to estrogen receptors, disrupting the natural hormonal balance and potentially causing a range of health problems. It’s essential to be aware of these environmental toxins and take steps to minimize exposure, such as choosing organic foods, using natural personal care products, and avoiding plastic containers. Other Non-Reproductive Effects of High Estrogen High estrogen levels can have a range of non-reproductive effects on the body, impacting various aspects of health and well-being. Some of the common non-reproductive effects include: Weight gain and obesity: Elevated estrogen levels can lead to increased body fat, particularly around the abdomen, contributing to obesity. Mood swings and emotional changes: High estrogen can cause mood swings, irritability, and even depression. Fatigue and low energy: Men with high estrogen levels may experience chronic fatigue and a general lack of energy. Insomnia and sleep disturbances: Hormonal imbalances can disrupt sleep patterns, leading to insomnia and poor sleep quality. Skin problems: High estrogen levels can cause skin issues such as acne and rosacea, affecting overall skin health. Maintaining balanced estrogen levels is essential for overall health and well-being, and addressing any hormonal imbalances can help alleviate these symptoms. Foods that Lower Estrogen: Cruciferous Vegetables and Sulforaphane Cruciferous vegetables, such as broccoli, cauliflower, and Brussels sprouts, are known for their ability to help lower estrogen levels in the body. These vegetables contain a compound called sulforaphane, which has been shown to support the detoxification of excess estrogen. Incorporating cruciferous vegetables into your diet can help maintain healthy estrogen levels and support overall hormonal balance. Additionally, these vegetables are rich in fiber and other essential nutrients, making them a valuable addition to a healthy diet. By including more cruciferous vegetables in your meals, you can naturally help regulate estrogen levels and promote better health. Buy an affordable, ultrasensitive estradiol test:   I hope you enjoyed the presentation. Please remember to subscribe to the ExcelMale forum and the ExcelMale YouTube channel, and make sure that you click on that little bell that will tell you when I upload new videos. Thanks a lot, and stay safe. More information about high estradiol in men Citations Understanding Blood Test Results: Estradiol (Male) Aromatase Inhibitors in Men: Mechanisms and Benefits Aromatase Inhibitors: No More, No Less Estrogen in Men: Understanding Its Role and Effects The Role of Estradiol in Male Reproductive Health Effects of Estrogen on Men's Health Estrogen in Men: What You Need to Know Estrogen's Impact on Men's Health: A Scientific Study When to Take Anastrozole with Testosterone Estrogen and Male Health: Research Findings The Role of Estrogen in Men's Health When to Use Aromatase Inhibitor with TRT What Causes High Estradiol Levels in Males?  

Pregnenolone for Men: An Overview of this Neurosteroid and Men’s Health Pregnenolone is a steroid hormone and natural steroid in the human body and has recently been in the spotlight in medical research, especially when it comes to men’s health. Low pregnenolone levels can cause muscle loss in aging men. This article will look into different studies that are looking into the role of pregnenolone, including the administration of pregnenolone for brain function, hormone balance, and how it can be used to treat schizophrenia. By looking into research papers, we will give you an overview of how pregnenolone affects men’s health. What is the neurosteroid pregnenolone? You could say pregnenolone is the “father” of all hormones! Your body makes hormones from cholesterol, the sterol lipid molecule made in our liver. But your body has to go through a process to make hormones like testosterone, estrogen, DHT, and so on. First it has to convert the cholesterol into pregnenolone, the mother of all hormones. From there it can make progesterone (where cortisol comes from) and DHEA (which is needed to make testosterone). This process is important because pregnenolone is a precursor to testicular steroid hormones, including testosterone, which are important for reproductive health and male sexual function. The synthesis of testicular steroid hormones happens in the mitochondria, where pregnenolone is produced and then converted into testosterone and other hormones. This process is important for overall hormonal balance and has big implications for reproductive health. But that first step (converting cholesterol into pregnenolone) is the most important step. Pregnenolone is the precursor to all these other hormones, as you can see in the chart below: In a young adult male, pregnenolone levels are at their peak. But as you age, the levels of this precursor hormone drop and the body’s response to it. At 75 years old, our body produces only 40% of the pregnenolone it needs. That’s a big drop in the precursor hormone, which means a big drop in all the hormones derived from pregnenolone. Before we get into the studies, let’s first understand what pregnenolone is and its basics. Pregnenolone is often referred to as a neurosteroid; it’s a precursor to many other steroids, including testosterone. It’s produced in the adrenal glands, brain, and gonads. This neurosteroid plays a big role in synaptic plasticity, cognitive function, and mood regulation. Definition and Biochemical Profile of Pregnenolone Pregnenolone is a naturally occurring steroid hormone in the human body produced primarily in the adrenal glands, brain, and gonads. It’s produced from cholesterol through the action of the enzyme cholesterol desmolase. This process converts cholesterol into pregnenolone, which then becomes a precursor to many other steroid hormones. Pregnenolone is lipophilic, meaning it can easily cross cell membranes, including the blood-brain barrier, so it can exert its effects all over the body. Its biochemical profile is characterized by its ability to be converted into other steroid hormones such as testosterone, progesterone, and cortisol through a series of enzyme-catalyzed reactions. This versatility is the reason why it’s important for many physiological functions. Role of Pregnenolone in the Body Pregnenolone plays a big role in many physiological processes, including stress response, mood regulation, and immune system modulation. As a precursor to other steroid hormones like testosterone, progesterone, and cortisol, pregnenolone is important for overall hormonal balance. As a neurosteroid, it’s especially important for cognitive health. Research has shown that pregnenolone can improve memory, protect against neural degeneration, and potentially improve focus and mental clarity. Pregnenolone also supports overall hormonal balance, which is important for overall health and well-being. By being a precursor to other steroid hormones, pregnenolone regulates many bodily functions, from stress response to reproductive health. Pregnenolone for Men: Supplementation Routes and Doses Pregnenolone can be administered orally, subcutaneously, intravenously, intranasally, topically, or transdermally. Oral pregnenolone has high metabolism and low bioavailability. It’s lipophilic and can cross the blood-brain barrier. There is very limited data on the pharmacokinetics of exogenous pregnenolone. When taken orally, allopregnanolone breaks down pregnenolone faster than other hormones made from pregnenolone substrates like cortisol or DHEA. One study showed that 3 hours after oral intake of 400 mg of pregnenolone, pregnenolone serum levels increased by 60%. 2 hours after that, allopregnanolone serum levels tripled. Another study showed that a single oral dose of 175 mg of pregnenolone doubled pregnenolone serum levels for 4-8 hours. One study by Marx et al. (2009) looked at the effects of exogenous pregnenolone in patients with schizophrenia or schizoaffective disorder. Participants were given 8 weeks of oral pregnenolone with an escalating fixed dose, 500 mg for the last 4 weeks. Pregnenolone and downstream metabolites were measured in the serum. Pregnenolone sulfate was 3x higher, allopregnanolone was 5x higher and serum pregnenolone was 4x higher when taken orally. Oral pregnenolone also increased progesterone in the blood by 4x and DHEAS by 16%. Exogenous pregnenolone did not increase serum testosterone, free testosterone, cortisol, DHEA, estradiol, or androstenedione. Pregnenolone and Allopregnanolone in Anxiety: Pregnenolone is a hormone in the human body and is the precursor to allopregnanolone. This is important because allopregnanolone regulates mood and emotional states through the central nervous system and the body’s stress response. Higher levels of allopregnanolone have been linked to reduced anxiety symptoms. This anxiolytic effect shows the hormone’s impact on mental health. Blocking or inhibiting allopregnanolone can have negative effects on social and affective functioning. So if allopregnanolone production or activity is slowed down, it can make it harder to interact with others and control your emotions. This is how important the hormone is for mental health and social well-being. Have you ever wondered how your brain handles emotions, especially during stress or anxiety? This has been a question for scientists for a long time. A recent study looked into the role of a neurosteroid called allopregnanolone in emotional regulation. This is a calming substance and has been linked to anxiety reduction. But how it affects our brain’s emotional control circuits has been a mystery until now. To better understand allopregnanolone’s role, researchers did an innovative experiment. They gave 400 mg of pregnenolone (a precursor to allopregnanolone) to 16 participants and a placebo to 15 others. The participants then did a brain scan (3T fMRI) while doing the Shifted-Attention Emotion Appraisal Task (SEAT). This task is designed to measure emotional processing and regulation. The results were interesting. Compared to the placebo group, the allopregnanolone group had reduced activity in two brain regions: the amygdala and the insula. These areas are responsible for generating negative emotions like fear and anxiety. Allopregnanolone made the dorsomedial prefrontal cortex work harder during the emotion judgment part of the task. This is the part of the brain that controls emotions. It also increased the connection between the amygdala and this region. This was correlated with lower self-reported anxiety in the participants. Pregnenolone in Schizophrenia Treatment Several studies have looked into the use of pregnenolone in schizophrenia, a mental disorder characterized by cognitive and mood disturbances. For example, Marx et al. (2014) did a randomized controlled trial to test the efficacy of pregnenolone in schizophrenia. They found some improvement in cognitive functions and symptom reduction. Marx et al. (2009) also looked into the effects of pregnenolone on cognitive and negative symptoms in schizophrenia. This proof-of-concept study confirmed the potential of pregnenolone in improving cognitive functions in schizophrenia patients. Ritsner (2010) gives a broader view of pregnenolone, dehydroepiandrosterone (DHEA), and their changes in schizophrenia. This study tells us a lot about the hormone changes in men with schizophrenia so the potential therapeutic role of pregnenolone is even clearer. Cognitive Function and Mood Enhancements Beyond schizophrenia, pregnenolone’s role in general cognitive health and mood improvement has been looked into, especially in relation to promoting deep sleep. Osuji et al. (2010) studied the effects of pregnenolone on cognition and mood in dual-diagnosis patients. Their study suggested the potential of pregnenolone to improve cognitive function and mood but only in a specific patient group. Hormonal Effects in Men The hormonal effects of pregnenolone, especially on testosterone and total testosterone, have been studied. Pregnenolone is converted into testosterone in the testes and changes in pregnenolone levels can affect overall reproductive health and male sexual function. In 2023, Bracci et al. looked into the changes in pregnenolone and testosterone in male shift workers. This study showed how work schedules can affect hormonal balance. Their results showed the importance of pregnenolone in maintaining hormonal balance for sexual health. Pregnenolone in Age-Related Hormonal Changes Morley (2013) reviewed the role of pregnenolone in age-related hormonal changes, specifically on rejuvenation and vitality. His overview of hormone treatments for rejuvenation mentions the importance of pregnenolone in maintaining hormonal balance as men age. Pregnenolone’s role in synaptic plasticity Synaptic plasticity is a term in neuroscience, the study of the brain and nervous system. To understand it, think of your brain as a network of roads, where each road is a connection between brain cells (neurons). These roads are called synapses. Think of these roads as changeable. Some can become wider or more used, making the travel (or communication) between brain cells faster and stronger. Others can become less used or even disappear. This changing nature of the roads (synapses) is what we call synaptic plasticity. This is like learning and memory in the brain. When you learn something new or remember something, the roads in your brain adjust. Some connections become stronger because you use them more (like practicing a skill), and others weaken because you use them less. So, synaptic plasticity is the brain’s ability to rewire itself based on experiences, learning, and memory. It’s why we can learn new things and remember them. This flexibility is important for our brain’s growth and adaptation throughout our lives. Smith et al. (2014) reviewed the role of pregnenolone in synaptic plasticity. Their study showed the role of neurosteroids in modulating synaptic plasticity, which has implications for cognitive functions and mental health. One of the important findings of Dr. Smith’s team was that pregnenolone helps brain cells communicate, especially in ways that are important for learning and remembering things. This communication happens through something called the N-methyl-D-aspartate receptor (NMDAR), which is like a tiny receiver on brain cells that helps them talk to each other. These scientists found that pregnenolone can move these NMDARs to where they’re needed on the brain cell surface. It does this with the help of calcium ions (tiny particles) and G-protein-coupled receptors. Also, pregnenolone can increase the levels of calcium inside brain cells, which is really important for strengthening brain cell connections. This strengthening is what helps us learn and remember things. Testosterone Replacement Therapy and Anabolics Decrease Upstream Hormones like Pregnenolone To fully understand pregnenolone’s effects, we also need to understand its relationship with testosterone and other steroid precursors. In 1985, Ruokonen et al. studied how serum testosterone and its precursor steroids responded to anabolic steroids and testosterone administration. This study gave us a basic idea of how pregnenolone works with other hormones. High doses of testosterone and anabolic steroids were used for 26 weeks by power athletes and then stopped for 16 weeks. During the 26 weeks of steroid use, SHBG and CBG in their blood changed. After 16 weeks of follow-up, serum testosterone and androstenedione increased (P < 0.05), but pregnenolone, 17-hydroxypregnenolone, dehydroepiandrosterone, 5-androstene-3 beta, 17 beta-diol, progesterone, and 17-hydroxyprogesterone decreased (P < 0.001). Pregnenolone, 17-hydroxypregnenolone, and dehydroepiandrosterone sulfate in the blood and free steroids changed, but 5-androstene-3 beta, 17 beta-diol, and testosterone sulfate remained the same during follow-up. During drug use, SHBG decreased by 80-90% and remained low for 16 weeks after steroid withdrawal. Steroids had no effect on serum CBG. In summary, taking testosterone and anabolic steroids by themselves messed up the testicular endocrine system. Low levels of testosterone precursors, a high ratio of testosterone to its precursor steroids and low SHBG were the indicators of this. Low levels of SHBG and testicular steroids were still present during the 16 weeks after drug withdrawal. If dehydroepiandrosterone and its sulfate are low in the blood, it means anabolic androgenic steroids also stop the adrenal glands from producing androgens. Pregnenolone Side Effects Now, as with any hormone, there are downsides to pregnenolone supplementation. Not everyone will experience side effects but most users report one or more of the following: Bloating—Many pregnenolone users have reported feeling bloated and puffy with regular use even when taken with DHEA or other steroid hormones. This may be because pregnenolone increases the production of ALL sex hormones, including estradiol (the precursor to estrogen). An increase in estrogen can cause water retention and bloating. High Estrogen Levels—As mentioned above, pregnenolone is converted into all sorts of sex hormones, including various forms of estradiol. This increase in estradiol can raise your estrogen levels. Weird Dreams—Many people taking pregnenolone have reported weird dreams after taking the supplement. While pregnenolone can reduce anxiety and stress (as above), it can make your brain overactive when you sleep and may cause weird dreams. Other Side Effects -- According to WebMD, "There isn't enough information to know if pregnenolone is safe when taken by mouth." However, it can cause effects similar to other steroid hormones: arrhythmia, hair loss, facial hair growth, headaches, mood changes, acne, anger, anxiety, irritability, and insomnia. For those with hormone-sensitive conditions (breast, ovarian, or uterine cancer, endometriosis), the hormone may exacerbate health problems since pregnenolone increases estrogen production. But the truth is, these side effects are really minimal. Pregnenolone is generally a safe supplement with limited side effects. Just be aware of what you're getting into when taking pregnenolone. Pregnenolone Safety and Side Effects Pregnenolone is generally safe but be aware of the side effects, especially with high doses or long-term use. Common side effects may include headaches, dizziness, and nausea. Consult with a healthcare provider before taking pregnenolone, especially if you're taking other medications or have underlying health conditions. Pregnenolone can interact with certain medications like hormone replacement therapy, blood thinners, or immune system modulators, which may alter their effectiveness or increase the risk of side effects. Getting proper medical guidance can minimize these risks and ensure safe and effective use of pregnenolone. How Much Pregnenolone Do You Need? If you're taking it to increase natural hormone production, you need to know HOW MUCH to take. You don't want to overdo it and end up with side effects! According to the Quest Diagnostics Manual: Men: 10 to 200 ng/dL Women: 10 to 230 ng/dL Children: 10 to 48 ng/dL Adolescent boys: 10 to 50 ng/dL Adolescent girls: 15 to 84 ng/dL Mean levels of pregnenolone don't differ significantly in postmenopausal women and elderly men (40 and 39 ng/dL, respectively). The typical dose of pregnenolone is 50 to 200 mg per day taken first thing in the morning. The pills are to be taken on an empty stomach or you can use a cream (transdermal application). But you may want to consult with your endocrinologist for professional medical advice before taking any pregnenolone. They may recommend a higher or lower dose depending on your pregnenolone levels or may advise against it, especially if you have underlying health conditions like cardiovascular diseases. Get a recommendation from a medical professional before taking any supplement, especially hormones like pregnenolone. BUY PREGNENOLONE TEST Questions About Pregnenolone for Men Does pregnenolone increase testosterone? Pregnenolone is a hormone that's a precursor to other hormones, including testosterone. While pregnenolone itself doesn't increase testosterone levels, it can play a role in the body's production of testosterone and other hormones. The effect of pregnenolone on testosterone levels may vary from person to person and depends on individual hormonal balance, overall health, and dosage. Consult with a healthcare provider or endocrinologist for personalized advice on hormone levels and supplementation. Does pregnenolone work for erectile dysfunction? Pregnenolone is a hormone that's being used as a supplement for various health conditions but has not been scientifically proven to treat erectile dysfunction. If you have erectile dysfunction, consult with a healthcare provider or a doctor who can give you options based on your individual health and situation. How does pregnenolone compare to other supplements men use for hormonal balance? Pregnenolone is a hormone that's a precursor to other hormones like testosterone, estrogen, and cortisol. When it comes to hormonal balance in men, pregnenolone has a unique role compared to other supplements used for this purpose. While supplements such as DHEA and testosterone boosters target specific hormones, pregnenolone serves as a building block for various other hormones in the body. This means pregnenolone can support overall hormonal balance by providing the raw material for hormone production. Consult with a healthcare provider before adding any new supplement to your regimen, especially when it comes to hormonal health. Where to buy Pregnenolone for Men? Pregnenolone for men can be found at health food stores, pharmacies, online supplement retailers, and some medical or wellness clinics. Make sure to buy from a reputable source to ensure quality and efficacy. Before starting any new supplement regimen, consult with a healthcare provider to determine the right dosage and if it's safe for your health needs. Buying Guide: What to Look For When choosing a pregnenolone supplement, consider the following factors to get a high-quality product. Look for supplements from reputable companies that have third-party testing for purity and potency. Check the dosage to match your individual needs and health goals. Also check the manufacturing standards of the product and opt for GMP. Consult with a healthcare provider before starting any supplement regimen, especially if you have underlying health conditions or are taking other medications. This will help you choose the right supplement and dosage for your needs. Research on pregnenolone shows its many roles in men's health, especially in cognitive function, mood regulation, and hormonal balance. While it shows promise in treating schizophrenia and improving cognitive and mood functions, more research is needed to fully understand its therapeutic potential and long-term effects. Buy your own pregnenolone test here. References Marx, Christine E. et al. “Proof-of-Concept Randomized Controlled Trial of Pregnenolone in Schizophrenia.” Psychopharmacology 231.17 (2014): 3647–3662. Bracci, Massimo et al. “Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers.” International journal of environmental research and public health 20.4 (2023): 3195-. MARX, Christine E et al. “Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia.” Neuropsychopharmacology (New York, N.Y.) 34.8 (2009): 1885–1903. Osuji, I. Julian et al. “Pregnenolone for Cognition and Mood in Dual Diagnosis Patients.” Psychiatry research 178.2 (2010): 309–312. Ritsner, Michael S. “Pregnenolone, Dehydroepiandrosterone, and Schizophrenia: Alterations and Clinical Trials.” CNS neuroscience & therapeutics 16.1 (2010): 32–44. Morley, John E. “Scientific Overview of Hormone Treatment Used for Rejuvenation.” Fertility and sterility 99.7 (2013): 1807–1813. Smith, Conor C., Terrell T. Gibbs, and David H. Farb. “Pregnenolone Sulfate as a Modulator of Synaptic Plasticity.” Psychopharmacology 231.17 (2014): 3537–3556.

Testosterone is more than just a sex hormone. It plays a crucial role in a range of physiological processes, including the development of muscle mass, bone density, and even the modulation of blood sugar levels. While high levels of testosterone can have their own set of complications, this article focuses on the often-underestimated risks associated with low testosterone levels. What is Low Testosterone? Low testosterone is a condition where the body does not produce sufficient amounts of the hormone. The threshold for low testosterone varies, but it is generally considered to be below 300 ng/dL (nanograms per deciliter) for adult men. The condition can lead to various health issues, ranging from metabolic syndrome to increased risk of death from all causes. Understanding the Causes of Low Testosterone:  Testosterone, the primary male sex hormone, plays a crucial role in maintaining a range of bodily functions, from muscle mass and fat distribution to bone density and red blood cell production. While it's common for testosterone levels to decline as men age, significantly low levels can lead to a host of health issues. But what causes low testosterone levels? The reasons are many and can range from genetic conditions to lifestyle choices. Let's break it down. Secondary Causes: Hypothalamic-Pituitary Dysfunction Idiopathic GnRH Deficiency, Kallman Syndrome, and More Sometimes, low testosterone can be due to issues with the pituitary gland or the hypothalamus, parts of the brain that signal the testicles to produce testosterone. Conditions such as Idiopathic GnRH deficiency and Kallman syndrome can disrupt these signals. These conditions are examples of hypogonadotropic hypogonadism (Bhasin et al., 2010). Inflammatory Causes Inflammation of the pituitary gland can also result in low testosterone. This inflammation can be due to a variety of factors, including autoimmune reactions and certain illnesses (Dandona & Rosenberg, 2010). Trauma and Tumors Blunt head trauma or postsurgical complications can affect the pituitary gland, leading to low testosterone. Tumors like pituitary adenomas or craniopharyngiomas can have similar effects (Wu et al., 2010). Vascular Insult Issues with the blood vessels that supply the pituitary, such as pituitary infarct/apoplexy or carotid aneurysm, can also be a culprit. Drug-Induced Causes Certain medications like anabolic steroids, opioids, and drugs that induce hyperprolactinemia can contribute to low testosterone. Always consult your doctor if you are on medication and experiencing symptoms of low testosterone (Bhasin et al., 2010). Systematic Illness and Autoimmune Causes Chronic illnesses such as anorexia nervosa, chronic renal failure, and liver failure can result in low testosterone. Autoimmune conditions that attack the pituitary gland (autoimmune hypophysis) can also be a factor (Dandona & Rosenberg, 2010). Primary Cause: Testicular Dysfunction Chromosomal and Genetic Factors Issues right at the level of the testicles can also be causes. Conditions like Klinefelter's syndrome, XX male gonadal dysgenesis, and defects in androgen biosynthesis are all chromosomal abnormalities that can lead to low testosterone (Wu et al., 2010). Infections and Surgeries Orchitis (inflammation of the testicles due to infections like mumps or HIV) and orchiectomy (surgical removal of the testicle) can directly affect testosterone production. Other Factors Chronic infections like tuberculosis, irradiation, testicular torsion, and certain medications can also be responsible. Lifestyle and Other Factors Factors like obesity, aging, malnutrition, and exposure to toxins such as heavy metals and alcohol can also influence testosterone levels (Dandona & Rosenberg, 2010). Low testosterone can result from a variety of causes, ranging from medical conditions and medications to lifestyle choices. If you're experiencing symptoms, it's crucial to consult a healthcare provider for a comprehensive diagnosis and treatment plan. Risks Associated with Different Levels of Low Testosterone < 450 ng/dl (15.3 nmol/l) - Risk of Metabolic Syndrome Metabolic syndrome is a cluster of conditions that include high blood pressure, elevated blood sugar levels, excess body fat, and abnormal cholesterol levels. Testosterone plays a significant role in regulating these physiological functions. Research by Dhindsa et al. has highlighted the increased risk of metabolic syndrome in men with testosterone levels below 450 ng/dl1. < 400 ng/dl (15.3 nmol/l) - Venous Leakage (Internal Penile Damage) Risk Venous leakage is a condition that can result in erectile dysfunction due to internal penile damage. According to a study by Yassin and Saad, men with testosterone levels below 400 ng/dl are at a higher risk of developing this condition2. < 350 ng/dl (11.9 nmol/l) – All-Cause Death Risk and Anemia Risk Khaw et al. conducted a study that showed men with testosterone levels below 350 ng/dl had an increased risk of death from all causes, as well as a higher risk of developing anemia3. < 300 ng/dL (10.2 nmol/L) - Lowered Libido, Weight Gain & Diabetes Risk Increased A low level of testosterone can also have a detrimental effect on sexual health, including a decrease in libido. Furthermore, it is associated with weight gain and an increased risk of developing diabetes. Traish et al. discussed these risks in their research4. < 300 ng/dL (10.2 nmol/L) - Quartile Risk of Fractures (Osteoporosis), Memory-Related Issues & Depression Risk Increases Testosterone is crucial for bone density. Low levels can increase the risk of fractures, memory-related issues, and even depression. A study by Orwoll et al. emphasized these risks5. < 250 ng/dl (8.5 nmol/l) - Arterial Plaque (Arteriosclerosis) & Sleep Quality Affected Vlachopoulos et al. found that men with testosterone levels below 250 ng/dl had a higher risk of developing arterial plaque, which can lead to arteriosclerosis. Additionally, these men experienced a reduction in sleep quality6. < 235 ng/dl (8.0 nmol/l) - Hardening of Arteries (Dialysis Patients) Carrero et al. identified that low testosterone levels can increase the mortality risk among male dialysis patients by promoting the hardening of arteries7. < 200 ng/dl (6.8 nmol/l) - Morning Erections Decrease A study by O'Connor et al. showed that men with testosterone levels below 200 ng/dl experienced a decrease in morning erections, which is often a sign of erectile dysfunction8. < 150 ng/dl (5.1 nmol/l) - Increased Inflammation (TNF-alpha) Malkin et al. found that extremely low levels of testosterone, under 150 ng/dl, were associated with increased inflammation markers like TNF-alpha9. Conclusion Low levels of testosterone are linked to a wide range of health issues. While testosterone replacement therapy is often recommended for men with low levels, understanding the risks associated with varying degrees of low testosterone is crucial for effective treatment and prevention. Always consult your healthcare provider for diagnosis and treatment.   Buy a Low Cost Total and Free Testosterone Test on DiscountedLabs.com: Testosterone test near me.   Low Testosterone: What Do Different Medical Guideline Groups Say? Understanding the guidelines for diagnosing and treating low testosterone is crucial for both healthcare providers and patients. Different medical organizations have released various guidelines over the years, making it essential to know how each defines low testosterone levels. This article aims to shed light on what various medical guideline groups have to say about low testosterone, focusing on cutoff values and expert opinions. Expert Opinion Before delving into specific guidelines, it's worth noting that expert opinion often plays a significant role in forming these guidelines. Medical professionals and researchers contribute to these guidelines based on clinical experience, existing studies, and ongoing research. Therefore, guidelines are not static but evolve over time, reflecting the current state of medical knowledge. Year of Release and Update Knowing when a particular guideline was released or updated is important as it indicates the currency and relevancy of the information. Here is a brief timeline:   ISSAM: 2005 Endocrine Society: 2006 ISSM: 2008 AUA: 2015 ICSM: 2015, updated in 2018  Cutoff Values of Testosterone for Laboratory Diagnosis One of the most critical aspects of diagnosing low testosterone is determining the cutoff values. Various organizations have different parameters. Here's a summary: Guideline Group Cutoff Values for Total T (TT) Cutoff Values for Free T Year ISSAM TT < 231 ng/dL (8 nmol/L) N/A 2005 Endocrine Society TT: 231-346 ng/dL (8-12 nmol/L) Free T < 52 pg/mL 2006 ISSM TT < 230 ng/dL (8 nmol/L) Free T < 52 pg/mL 2008 AUA TT: 230-350 ng/dL (8-12 nmol/L) Free T < 65 pg/mL 2015 ICSM TT < 300 ng/dL Free T < 5 ng/dL 2018 Definitions and Abbreviations: ISSAM: International Society for the Study of the Aging Male ISSM: International Society for Sexual Medicine ICSM: International Consultation for Sexual Medicine AUA: American Urological Association TT: Total Testosterone Free T: Free Testosterone SHBG: Sex Hormone-Binding Globulin Understanding the various guidelines for diagnosing low testosterone is crucial for appropriate treatment. It's evident that different medical organizations have varying cutoff values, and these may be subject to change as more research becomes available. Always consult your healthcare provider for the most current and personalized advice. By keeping updated on these guidelines, both physicians and patients can make more informed decisions regarding the diagnosis and treatment of low testosterone. Sources: International Society for the Study of the Aging Male (ISSAM), Guidelines, 2005. Endocrine Society, Clinical Guidelines, 2006. International Society for Sexual Medicine (ISSM), Guidelines, 2008. American Urological Association (AUA), Guidelines, 2015. International Consultation for Sexual Medicine (ICSM), Guidelines, 2015, updated in 2018.   Footnotes Dhindsa, S., Miller, M. G., McWhirter, C. L., Mager, D. E., Ghanim, H., Chaudhuri, A., & Dandona, P. (2010). Testosterone concentrations in diabetic and nondiabetic obese men. Diabetes Care, 33(6), 1186-1192. PubMed ↩ Yassin, A. A., & Saad, F. (2017). Testosterone Deficiency and Testosterone Treatment in Older Men. Gerontology, 63(2), 144–156. PubMed ↩ Khaw, K. T., Dowsett, M., Folkerd, E., Bingham, S., Wareham, N., Luben, R., ... & Day, N. (2007). Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men. Circulation, 116(23), 2694-2701. PubMed ↩ Traish, A. M., Saad, F., & Guay, A. (2009). The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction. Journal of Andrology, 30(1), 10-22. PubMed ↩ Orwoll, E., Lambert, L. C., Marshall, L. M., Phipps, K., Blank, J., Barrett-Connor, E., ... & Cummings, S. (2006). Testosterone and estradiol among older men. The Journal of Clinical Endocrinology & Metabolism, 91(4), 1336-1344. PubMed ↩ Vlachopoulos, C., Ioakeimidis, N., Miner, M., & Aggelis, A. (2014). Testosterone deficiency: a determinant of aortic stiffness in men. Atherosclerosis, 233(1), 278-283. PubMed ↩ Carrero, J. J., Qureshi, A. R., Parini, P., Arver, S., Lindholm, B., Bárány, P., ... & Stenvinkel, P. (2009). Low serum testosterone increases mortality risk among male dialysis patients. Journal of the American Society of Nephrology, 20(3), 613-620. PubMed ↩ O'Connor, D. B., Lee, D. M., Corona, G., Forti, G., Tajar, A., O'Neill, T. W., ... & EMAS Study Group. (2011). The relationships between sex hormones and sexual function in middle-aged and older European men. The Journal of Clinical Endocrinology & Metabolism, 96(10), E1577-E1587. PubMed ↩ Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004). The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. The Journal of Clinical Endocrinology & Metabolism, 89(7), 3313-3318. PubMed ↩

Thyroid Labs : Is TSH the Best Way to Measure Thyroid Function? The first signs of thyroid disorder are typically related to symptoms like fatigue, weight gain, cold intolerance, hair loss, sexual dysfunction, etc. and blood screening of Thyroid Stimulating Hormone (TSH) with other thyroid hormone biomarkers, including free thyroxine (T4), is necessary to assess thyroid function. This includes testing for specific thyroid health conditions such as underactive thyroid (hypothyroidism) and overactive thyroid (hyperthyroidism), also known as thyroid conditions. Unfortunately, some physicians only measure TSH as a way to diagnose low or high thyroid function. Even though some guidelines suggest a TSH range of 0.4–4.5 micro IU/mL, some patients may be experiencing hypothyroidism symptoms at TSH levels above 3 due to occult Hashimoto’s disease or other issues, so it is always a good idea to perform a thyroid panel that includes not only TSH but also free T3 and free T4. There is ongoing controversy about whether reliance on the TSH test—to the exclusion of clinical symptoms and other tests such as Free T4, Free T3, and antibody tests—is medically sound. That is a controversy that is unlikely to be decided for years. The situation today, however, is that the majority of physicians do rely almost exclusively on the TSH test to detect thyroid disease and monitor the effectiveness of treatment, which may not always accurately reflect the levels of enough thyroid hormone in the body. Additionally, weight loss is a common symptom of hyperthyroidism, making it important to consider when assessing thyroid function.   What is the Optimal TSH Range? Since 2003, the American Association of Clinical Endocrinologists has recommended that the normal range for TSH run from 0.3 to 3.0, versus the older range of 0.5 to 4.5. So, according to the new standards, levels above 3.0 are evidence of possible hypothyroidism, and levels below 0.3 are evidence of possible hyperthyroidism. However, there is disagreement among practitioners, and some follow the older range, while others use the newer range. An important thing to understand about TSH is that it is an inverse number when thinking about thyroid function. The higher it is, the more sluggish, underachieving and, generally, slow your thyroid is, indicating a lack of thyroid hormone. The lower it is, the more hyperactive, overachieving and, generally doing too much your thyroid, indicating an excess of thyroid hormone. Put another way: High TSH = hypothyroid, Low TSH = hyperthyroid. It is important to keep your TSH levels within the optimum range, as determined by your healthcare provider, to ensure proper thyroid hormone levels and overall health, including body temperature regulation. This small, butterfly-shaped gland, known as the pituitary gland, is located in the front of your neck and plays a crucial role in controlling your body's most important functions. TSH levels increase as T4 levels drop, and TSH levels decrease as T4 levels rise. The reason this is the most popular test in today’s medical model is that the only treatment offered for thyroid dysfunction is thyroid hormone replacement, specifically the medicine levothyroxine, and that’s what doctors are checking when they test your TSH. A TSH test alone doesn’t give you information about thyroid-pituitary communication, about T4 to T3 conversion in other parts of the body or about whether or not your immune system is attacking your thyroid. One important thing for people with the thyroid autoimmune Hashimoto disease to understand is that some antibodies can inhibit thyroid function by turning off instead of stimulating TSH receptors on cells. In this case, you will see high TSH and high thyroid antibodies, as well as nodules, which can be detected through thyroid antibody tests and thyroid imaging, such as a thyroid ultrasound. These tests are crucial in diagnosing autoimmune disorders like Graves’ disease or Hashimoto’s disease, and learning more about the optimum TSH range through resources such as the Thyroid Function Tests provided by the American Thyroid Association. What are Thyroid Stimulating Hormone (TSH) and Other Thyroid Labs? · TSH is used as a first line screening tool to assess thyroid disease. Additionally, health care providers check TSH to monitor disease progression and treatment · TSH is high in primary hypothyroidism · Low TSH occurs in hyperthyroidism · Evaluation of therapy in hypothyroid patients receiving various thyroid hormone preparations, although free T3 should also be evaluated along with patient’s symptoms · Range: 0.450−4.500 μIU/mL (>10 yr old). This range is in debate. · Methodology: Electrochemiluminescence immunoassay (ECLIA) T4 (Thyroxine), Total, Serum · Used for the diagnosis of hypothyroidism and hyperthyroidism · Free T4 is usually preferred instead of measuring total T4. · Reference Range: 4.5–12.0 μg/dL · Most physicians order serum free T4 instead of serum total T4 · Free T4 will provide a better evaluation of bioavailable thyroxine since it tests hormone that is not bound by proteins T4 (Thyroxine), Free, Serum The free T4 (FT4) assay measures the concentration of free thyroxine, the only biologically active fraction, in the serum (about 0.05% of the total T4). Free thyroxine is not affected by changes in concentrations of binding proteins such as TBG and thyroid binding prealbumin. Thus, such conditions as pregnancy, or estrogen and androgen therapy do not affect the FT4. Thus the FT4 assays generally are considered to provide the more reliable indication of true thyroid status because only the free hormone is physiologically active. In developing hypothyroidism, T4 (free T4) is the more sensitive indicator of developing disease than is T3 (Free T3), and is therefore preferred for confirming hypothyroidism that has already been suggested by an elevated TSH result. · Measurement of circulating thyroxine not bound to proteins (TBP) · Reference Interval: 0.82–1.77 ng/dl (>19 years old) · The thyroid gland produces and secretes T4, otherwise known as thyroxine. Proteins bind to T4 and carry it throughout the bloodstream. · Once in the tissues, T4 is released from the proteins and is now free to convert into the more active form called T3. · Many physicians believe that measuring free T4 is a more sensitive test for thyroid hormone production Reverse T3 (Triiodothyronine), Serum · LabCorp Reference Range: 9.2–24 ng/dL · Methodology: Liquid chromatography/tandem mass spectrometry (LC/MS-MS) · The reverse T3 level tends to follow the T4 level: low in hypothyroidism and high in hyperthyroidism · Increased levels of rT3 have been observed in starvation, anorexia nervosa, severe trauma and hemorrhagic shock, hepatic dysfunction, postoperative states, severe infection, and in burn patients (i.e., "sick euthyroid" syndrome) · This appears to be the result of switchover in deiodination functions, with the conversion of T4 to rT3 being favored over the production of T3 · The Journal of Clinical Endocrinology & Metabolism states that “the T3/rT3 ratio is the most useful marker for tissue hypothyroidism and as a marker of diminished cellular functioning.” T3 (Triiodothyronine), Total, Serum · Second-order testing for hyperthyroidism in patients with low thyroid-stimulating hormone values and normal thyroxine levels · Diagnosis of triiodothyronine toxicosis · Triiodothyronine (T3) values >200 ng/dL in adults or > age related cutoffs in children are consistent with hyperthyroidism or increased thyroid hormone-binding proteins. · In hypothyroidism, T4 and T3 levels are decreased. T3 levels are frequently low in sick or hospitalized euthyroid patients. · Total Triiodothyronine (T3) is not considered a reliable marker for hypothyroidism. · Free T3 is usually preferred instead of total T3 to provide a better evaluation of bioavailable triiodothyronine T3 (Triiodothyronine), Free, Serum The total T3 test measures the concentration of triiodothyronine in the serum. The T3 is increased in almost all cases of hyperthyroidism and usually goes up before the T4 does. As a result, T3 levels are preferable to total T4 levels for confirming hyperthyroidism that a suppressed TSH result has already suggested. T3 tests can also help rule out T3 thyrotoxicosis, a type of hyperthyroidism that shows up with T3 levels that are too high and TSH levels that are too low, while T4 levels stay within normal (euthyroid) limits. In hypothyroidism, the T3 is often normal, even when the T4 is low. Inderal steroids are just a few of the medications that have an impact on the T3, which decreases during acute illness and starvation. This test measures both bound and free hormones, including iodine, which is crucial for the production of thyroid hormones. And only the free hormone is biologically active. Since free T3 accounts for only about 0.5% of the total T3, measurement of free hormone is generally considered to provide a more reliable indication of true thyroid status. As noted above for T4 levels, anything which affects thyroid binding globulin (TBG) or albumin will affect the total T3 levels. Additionally, a radioactive iodine uptake test, also known as a thyroid uptake test, may be used to check thyroid function and diagnose hyperthyroidism. This test quantifies the amount of free T3—that is, T3 that is not protein-bound and accessible to tissues—in the body. · Many doctors believe that evaluating the levels of free T3 is the best indicator of thyroid function · Needed to determine the level of active thyroid hormone primarily responsible for regulating metabolism to fuel all cellular functions · Reference Interval: 2.0−4.4 pg/ml (>19 yr old) Thyroglobulin Antibody and Thyroglobulin · Measures antithyroglobulin antibodies that are commonly present in patients with Hashimoto's thyroiditis · Antibodies against the protein thyroglobulin can destroy thyroid cells. This destruction can lead to hypothyroidism · The test will identify the positive or negative presence of antibodies with reflex to confirm the accuracy · Usually ordered as part of a comprehensive thyroid panel when thyroid hormone deficiency is present with no conclusive diagnosis · Methodology: TgAb: Beckman Coulter immunometric assay, with either of the following methodologies used for reflex confirmation: Tg-IMA: Beckman Coulter immunometric assay; Tg: Liquid chromatography/tandem mass spectrometry (LC/MS-MS) Thyroid Peroxidase (TPO) Antibodies · Differential diagnosis of hypothyroidism and thyroiditis The most accurate way to find autoimmune thyroid diseases like Hashimoto's thyroiditis, idiopathic myxedema, and Graves disease is to measure TPO antibody levels. Most people who have these disorders have levels of anti-TPO antibodies that can be detected. · The highest TPO antibody levels are observed in patients suffering from Hashimoto thyroiditis. In this disease, the prevalence of TPO antibodies is about 90%, confirming the autoimmune origin of the disease · autoantibodies also frequently occur (60%–80%) in the course of Graves disease · Should be used in conjunction with antithyroglobulin test, since autoimmune thyroiditis may demonstrate a response to antigens other than thyroid microsomes · Range: 0-34 IU/ML (>19 years old) Thyroxine-binding Globulin (TBG Lab Test), Serum · Abnormal levels (high or low) of thyroid hormone-binding proteins (primarily albumin and thyroid-binding globulin) may cause abnormal T3 concentrations in euthyroid patients · Range: 13–39 ug/mL (>19 years old) · Methodology: Immunochemiluminometric assay (ICMA) BUY A COMPLETE THYROID PANEL WITH ANTIBODIES HERE   Citations: Demystifying Thyroid Supplementation Thyroid Function Tests and Risk of Alzheimer Disease: The Rotterdam Study Thyroid Function and Mortality: The Rotterdam Study Thyroid Testing Best Practices: Reverse That Order for Reverse T3 Thyroid Function and the Risk of Alzheimer Disease: A Population-Based Study Thyroid Hormone Therapy: New Insights and Approaches

  Thousands of men who want to know their testosterone levels frequently search "testosterone test near me" online. When you have low testosterone, you'll experience some symptoms, such as chronic fatigue, confusion, low sex drive, poor gym performance, and others. Thankfully, it's increasingly affordable and accessible to test your testosterone numbers and see how you stand. Table of Contents How "Testosterone Testing Near Me" Works? Discover Some of the Most Popular Testosterone Tests What Is the Normal Testosterone Range? Check Out These Natural Testosterone Boosters Work Out Regularly Stop Smoking Do Breathing Exercises Get Enough Sleep Order Your Testosterone Test Today! References: If you have one or more of these symptoms, it's highly recommended that you test your testosterone levels immediately. Keep reading to learn more about this subject and how testosterone testing works. How "Testosterone Testing Near Me" Works? The fastest way to check your testosterone levels is by buying a T test online from a reputable vendor and visiting the nearest clinic to draw blood. After you purchase the testosterone test, you will receive an email with a form you should print. When you visit the clinic for sample collection, you take this paper with you. Your blood will be analyzed in special laboratories using the best and most accurate medical technology. This technology is known as LC/MS and stands for liquid chromatography and mass spectrometry. The technology is genuine and offers results quickly. You will receive an email with the results, and you can ask your doctor to help you interpret them. Everything is safe, quick, and confidential. Discover Some of the Most Popular Testosterone Tests You can confidently pick from many testosterone tests and panels, depending on your preferences and needs. For example, some testosterone panels are specially formulated for amateur bodybuilders, experienced bodybuilders, people with low T levels, people already on TRT, etc. Your primary healthcare provider should be able to help you pick the right testosterone panel for your needs. Some panels check other substances as well, not only testosterone. For example, the TRT Monitoring Panel looks at your hematocrit and checks your liver and kidney health and estradiol and testosterone levels. Knowing more about these hormones helps you adjust your TRT protocol for optimal results. Other testosterone panels help you assess your fertility status. They test multiple substances, such as your prolactin, DHT, DHEA levels, and several thyroid hormones. You can also order a TRT Follow-Up Panel that checks most of your system's essential hormones and substances. This panel is required after completing a few weeks of a TRT protocol to ensure optimal health. If you're new to testosterone testing, it's recommended that you go for a simple panel that looks at both your free and total testosterone levels. This type of test is inexpensive, easy to understand, and provides the foundation for subsequent testosterone testing, especially if you decide to start a TRT protocol. What Is the Normal Testosterone Range? As you can probably imagine, men's testosterone levels are much higher than women's. This condition is usually known as hypogonadism if your T level is lower than the normal range. For example, men's normal testosterone range is between 300 ng/dl and 1000 ng/dl of blood. If your T levels are lower than 300 ng/dl of blood, you might be a suitable candidate for testosterone replacement therapy. Normal T levels ensure proper reproduction parameters, stable mood, good cognition, and a general state of well-being. For women, the normal testosterone range is between 15 ng/dl and 70 ng/dl of blood. If a woman has less testosterone than normal, she might experience changes in breast tissue and even encounter fertility problems. Check Out These Natural Testosterone Boosters As mentioned earlier, low T levels make you a good candidate for TRT. You should discuss this with your TRT doctor and find out all the ins and outs of this treatment. At the same time, there are many things you can do to boost your T levels naturally. Here are a few ideas. Work Out Regularly Mild physical activity a few times per week will instantly improve your T levels and make you feel better. For example, you can go to the gym thrice a week, run in your nearest public park, lift weights, or join a self-defense class. All these activities will naturally boost your testosterone, whether you're a person. Stop Smoking Smoking cigars or cigarettes is linked to all sorts of health problems. This bad habit naturally lowers your testosterone production because you're willingly putting a host of toxins and heavy metals in your body. On top of reducing your T levels, regular smoking also ruins your stamina and cardiovascular system and can lead to erectile dysfunction. Do Breathing Exercises Bringing more oxygen into your body can naturally rejuvenate your tissues and restore metabolic processes. Try to breathe deeply a few times daily or practice deep breathing for 15-20 minutes daily. This will automatically improve your endocrine and hormonal health; as a result, your testosterone production will return to normal. Get Enough Sleep Please make sure that you regularly get enough sleep to make sure you have the best testosterone levels. Sleeping at least 7 hours per night should be sufficient for most people. If you routinely sleep less than that because of a hectic lifestyle, try to make up for this "sleep debt" by sleeping 10+ hours whenever you have a free day. If you're constantly sleep-deprived, your hormones will get out of balance. Order Your Testosterone Test Today! Checking testosterone levels is inexpensive these days, and you can get the results back in a few business days. Keep in mind that your testosterone levels can profoundly influence the quality of your life. Your enjoyment will decrease dramatically if you have low T levels and don't do anything about it. Go to DiscountedLabs.com today and order the Testosterone Total and Free Test. You can compare your results against reference values and see what's to be done from there. ================= References: 8 Proven Ways to Increase Testosterone Levels Naturally Testosterone Information | Mount Sinai - New York Testosterone: When and How to Balance Low T        

Key Highlights Sex hormone-binding globulin (SHBG) plays an important role in keeping hormones balanced. It is essential for good health. SHBG controls the amount of sexual hormones, like testosterone and estrogen, in your body. By binding to these hormones, it helps manage their activity. A proper balance of SHBG is key for overall well-being. It is important to test your shbg levels. This helps in finding and treating various health problems. Learn what high and low SHBG levels mean for your health. Understand why some at-risk groups need to check their SHBG levels regularly. Discover simple and cost-effective ways for SHBG testing without a doctor's appointment. Introduction Understanding your sex hormone-binding globulin (SHBG) levels is important for your health. SHBG helps keep your hormones balanced. It can influence things like testosterone levels and thyroid hormone production. If your SHBG levels are too high or too low, it may indicate that you have health issues. Testing your SHBG levels can provide helpful information about your hormonal health. This test can help detect conditions such as liver disease or polycystic ovary syndrome early, in conjunction with other tests. This allows you to get the treatment you need sooner. Understanding SHBG and Its Role in Your Health SHBG stands for sex hormone binding globulin. It is a key protein in our blood. This protein binds to hormones like testosterone and dihydrotestosterone (DHT). When it binds, it helps control the free hormones that the tissues can use. This is very important because females have testosterone in smaller amounts, while too much testosterone can lead to a variety of issues. SHBG affects many functions in our bodies. It is crucial to understand SHBG levels. If these levels are not balanced, it can lead to problems like low testosterone or too much estrogen. These issues can impact fertility, libido, and overall health. To maintain hormone balance and help with health problems, regular testing of SHBG levels is important. What is SHBG and Why is It Important? SHBG means Sex Hormone Binding Globulin. It is a blood transport protein that carries sex hormones such as testosterone and estrogen. SHBG plays a key role in managing how these hormones function and their levels in the body. This impacts several areas of health, such as fertility, metabolism, and overall hormone balance. How SHBG Affects Hormone Balance and Health SHBG plays a key role in keeping hormones balanced and supporting good health. It connects with sex hormones like testosterone and estrogen. This connection helps manage how much of these hormones the body can use. When SHBG levels are too high, it can lead to symptoms of hormone deficiency. If SHBG is low, there may be too many free hormones. This can cause issues like acne or infertility. It is important to know how SHBG affects hormone balance. This knowledge helps manage different health problems and promotes overall wellness. Maintaining proper SHBG levels is essential for a healthy balance of hormones and overall health. The Link Between SHBG Levels and Health Conditions SHBG levels are key to our health. When SHBG levels are high, it can mean issues like liver disease or hyperthyroidism. When they are low, it might be linked to obesity or polycystic ovary syndrome. A change in SHBG can impact our hormones and cause problems like erectile dysfunction or infertility. Knowing how SHBG levels connect to health conditions can help us manage our health better. Regular testing and monitoring give us important information on risks and assist with early treatment. High SHBG Levels: What They Mean and Possible Health Implications Elevated SHBG levels, or high levels of SHBG, can signal issues like liver disease or hyperthyroidism. Additionally, hormone replacement therapy and other medications like estrogen can cause high SHBG. High SHBG levels can reduce free testosterone levels, which can hurt testosterone production. This can lead to problems with libido, muscle mass, and bone density. People with high SHBG may feel tired, gain weight, or experience reduced sexual function. It is important to know about elevated SHBG levels to manage hormonal imbalances and stay healthy. Regular check-ups and proper actions can help maintain a good hormonal balance. Low SHBG Levels: Symptoms and Associated Conditions Individuals with low SHBG levels can have several symptoms, particularly during puberty. These might include problems like hypogonadism and low testosterone levels. For women, low SHBG can cause irregular menstrual cycles, acne, and unwanted hair growth. For men, it can lead to erectile dysfunction, decreased libido, and infertility. Low SHBG levels are also linked to a higher risk of type 2 diabetes, insulin resistance, and obesity. These issues come from changes in hormone levels. Testing SHBG levels is crucial. It helps find these symptoms and conditions early. When we detect them early, we can manage and treat the problems better. It is important to note that testosterone therapy and anabolic agents decrease SHBG and increase free testosterone. Why and When to Test Your Serum Sex Hormone Binding Globulin Level Testing your SHBG levels is important for checking hormone balance and overall health. If you have symptoms like low libido or infertility, SHBG testing can help find hormone issues. It is good to check these levels often, especially for people who are at risk, like those with liver disease or polycystic ovary syndrome. This helps ensure SHBG levels stay in the normal range. By understanding how SHBG affects sex hormone levels, you can make better health choices and quickly address any problems that arise. Identifying Symptoms That Warrant an SHBG Test Feeling tired, having irregular periods, or dealing with symptoms of high testosterone like acne could mean you need an SHBG test. Other signs to watch for include low sex drive, sudden weight gain, or difficulty getting pregnant. These could all suggest issues with sex hormone-binding globulin levels. If you notice ongoing symptoms related to hormone levels or reproductive health, it might be a good idea to talk to your doctor about an SHBG test along with other important evaluations. Finding problems early with the right tests can help you get quick treatment. Regular Monitoring for At-Risk Groups Regularly checking SHBG levels is very important. This is especially true for those who might have hormone problems. People at risk include postmenopausal women, people with liver disease, and those with polycystic ovary syndrome. They should consider getting SHBG tests now and then. Keeping track of these levels can help spot issues early and manage conditions better. By being active in checking SHBG levels, people in these groups can work to keep their hormones balanced and stay healthy. Always remember, regular checks are key to avoiding possible health issues. Accessing SHBG Testing: Affordable and Convenient Options For people who want to check their SHBG levels easily and affordably, there are several good options. You can use lab tests and testing services that go directly to consumers. These options let you order an SHBG blood test online, ensuring a fast turnaround time. You do not need to see a doctor, and the prices are reasonable. You will only give a small amount of blood sample at a local lab. After that, you will quickly receive clear results for your SHBG testing. This method makes it simple to monitor your hormone health. How to Get an SHBG Test Without a Doctor Visit Discounted Labs sells an affordable SHBG test available online without a doctor visit if you live in the following states: Alabama, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa (Des Moines), Kansas, Kentucky (Louisville & Lexington), Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana (Great Falls), Nebraska (Omaha & Lincoln), Nevada, North Carolina, New Mexico, Ohio (Cleveland & Akron), Oklahoma (OKC), Oregon, Pennsylvania, South Carolina, Tennessee, Texas, Utah (Salt Lake City), Virginia, and Washington. Understanding the Costs: No Insurance Required If you want to check your SHBG levels and you don’t have insurance, there are budget-friendly options. Some labs allow you to order tests online without visiting a doctor. The prices usually range from $45 (Discounted Labs) to $150. The cost varies based on the lab and the tests you need. By not using insurance, you can take better control of your health. You can affordably access important information about your hormone levels. Don’t let insurance limits hold you back from checking your SHBG levels regularly. Conclusion Monitoring your sex hormone-binding globulin (SHBG) levels is very important. It helps you learn about your hormone balance and health. Checking SHBG levels along with total testosterone can help find problems. This could include hormonal imbalances, liver disease, or polycystic ovary syndrome. SHBG testing provides useful information about different health issues. This can lead to timely care and better treatment plans that fit your needs. Regular SHBG testing is especially beneficial for those at risk. It can help keep hormone levels healthy and prevent potential health problems. Be proactive and check your SHBG levels regularly. Frequently Asked Questions Who Should Consider Testing Their SHBG Levels? Understanding your SHBG levels is important for your health. If you have hormonal imbalances, low or high testosterone, or health issues like PCOS or thyroid problems, you should consider SHBG level testing. It is also important to check these levels regularly if you are in a risk group. How Often Should I Test My SHBG Levels? Regular monitoring is important. You should consider testing SHBG levels each year or when your doctor suggests it. Watching these levels can help you notice changes, see how well treatment is working, and keep your hormones balanced. Can Diet and Lifestyle Affect SHBG Levels? Eating a balanced diet and staying active can change your SHBG levels. Factors like food choices, exercise, and handling stress can affect how much SHBG your body produces. This can also impact your hormone balance and overall health. Understanding how these factors connect can help you keep your SHBG levels at their best. What Steps Should I Take if My SHBG Levels Are Abnormal? If your SHBG levels are not right, you should speak with a healthcare provider. They can explain what is happening. Treatment options will depend on why your SHBG levels are off. You may need to change your lifestyle, adjust your medications, or consider hormone therapy to get back to normal. It is also important to check your levels regularly. This way, you can see how well the treatment is working and make changes if needed.

Understanding High PSA Levels: A Prostate Health Guide PSA is also known as the prostate-specific antigen. This is a protein that your prostate gland naturally produces. In healthy individuals, PSA levels are small all the time, and this type of protein circulates freely through the bloodstream. However, doctors and researchers have discovered that PSA can get really high sometimes. This is usually because the patient has a significant prostate infection or prostate cancer. Developing prostate cancer is something that scares most people, but luckily, high PSA levels don't necessarily mean that you have cancer. Dive into this article and learn why sometimes your PSA levels are high, yet this is not a diagnosis for cancer. Table of Contents Understanding High PSA Levels: A Prostate Health Guide What Are Normal PSA Levels? Your Age Might Naturally Increase PSA Levels Prostatitis Can Also Cause High PSA Levels Having a Recent Medical Procedure Might Raise PSA Levels Benign Prostatic Hyperplasia Could Also Cause High PSA Levels If You Exercise Often, Your PSA Levels Might Increase. Having a urinary tract infection could cause high PSA levels Why Should You Order a PSA Test? Free PSA vs. Regular PSA Test Order Your PSA Test From DiscountedLabs Today! What Are Normal PSA Levels? PSA can fluctuate in the bloodstream depending on various factors. However, individuals who don't have prostate cancer have PSA levels under 4 ng/mL. Most often, healthy men have PSA levels revolving around 1-2 ng/mL. At the same time, scientists have discovered that PSA levels above 4 ng/ml usually translate into prostate cancer. Some cancer patients have PSA levels above 6 or even 7 ng/ml, and they usually receive some sort of treatment to bring these levels down. Your Age Might Naturally Increase PSA Levels Now that you know what the normal levels of PSA are, it's time to see how age affects it. Men who are 50 years of age or older begin to see a significant spike in their PSA levels. This happens because the prostate tissue naturally produces more PSA. Men in their 70s usually have higher PSA levels than normal. However, this doesn't automatically mean that they have cancer. In many cases, screening seniors for PSA levels might result in false positives. Other types of tests are necessary, besides a PSA test, to determine if a patient has cancer or not. Therefore, if you or your dad have high PSA levels, you shouldn't be scared because this doesn't usually translate into prostate cancer. Prostatitis Can Also Cause High PSA Levels Prostatitis is nothing but an inflammation of the prostate tissue. It can happen to men of all ages, and it comes with various symptoms. For example, patients who have prostatitis experience mild fever, difficulty urinating, or painful ejaculations. Feeling pressure in the rectum area is another sign of prostatitis. Some men may experience something known as chronic nonbacterial prostatitis or chronic pelvic pain syndrome. These individuals with CNP or CPPS might experience symptoms similar to prostatitis. For example, they might complain of mild lower back pain, painful ejaculation, and discomfort in the pelvic area. In some cases, prostatitis can be asymptomatic as well. For many patients, prostatitis can be a chronic problem, but this is not a confirmed diagnosis for prostate cancer. Having a Recent Medical Procedure Might Raise PSA Levels Different types of medical procedures done on the prostate tissue or urinary tract might make the prostate produce more PSA. For example, if you've had a recent prostate exam, your PSA levels are probably higher than normal. At the same time, having a urinary catheter inserted in the urethra can cause mild irritation and make the prostate tissue release more PSA. As a rule of thumb, patients should wait a few weeks after having a procedure before they take a PSA test. Benign Prostatic Hyperplasia Could Also Cause High PSA Levels Benign prostatic hyperplasia, or BPH, is another reason why your PSA levels are high, but you don't have prostate cancer. This type of condition is frequently encountered among older men. It is an enlargement of the prostate tissue, and it's usually accompanied by symptoms similar to prostatitis. At the same time, BPH can have similar symptoms as those experienced by those with prostate cancer. This includes painful urination and problems with ejaculation. If You Exercise Often, Your PSA Levels Might Increase. Different types of vigorous exercises, such as running or high-intensity interval training, can increase your PSA levels and potentially contribute to prostate problems. They will eventually remain elevated for a few days. That's why you need to stop exercising for at least two days before going for an early-detection PSA test. Bicycle riding is especially linked to potentially increased PSA levels. Factors that might affect PSA levels include certain medicines, such as 5-alpha reductase inhibitors like finasteride (Proscar or Propecia) or dutasteride (Avodart), which can lower PSA levels. According to the National Cancer Institute, a PSA test can find high levels of PSA that may mean a person has prostate cancer. An elevated PSA level can also be caused by other problems with the prostate, like an enlarged or inflamed prostate. Therefore, determining what a high PSA score means can be complicated. To decide whether to have a PSA test, discuss the issue with your doctor, considering your risk factors and weighing your personal preferences. A higher level of PSA means a higher risk of prostate cancer. A high PSA level can be the first sign of prostate cancer and can also indicate less serious conditions, such as an enlarged prostate. Keep up with your regular appointments and tests so your care team can keep tabs on your health. If you’re experiencing prostate symptoms, such as an enlarged prostate, dull pain in the lower pelvic area, frequent urination, and pain or difficulty while urinating, it is important to consult a healthcare professional for further evaluation and diagnosis. If your PSA level is high, a prostate biopsy is the only way to find out if the cause is cancer. And prostate biopsies have possible harm. Having a urinary tract infection could cause high PSA levels Urinary tract infections might also increase your PSA levels. These are common among men, and they can cause irritation to the prostate tissue. As a result, the prostate will produce more PSA and give a false positive for prostate cancer to a PSA test. The level of the urinary tract infection can also affect how much PSA the prostate produces. For example, those who experience painful urination, blood in the urine, and other serious symptoms usually have their PSA levels increase. Why Should You Order a PSA Test? It's important to understand that you can have various symptoms, such as painful urination, pelvic pain, abdominal discomfort, and back pain, without having prostate cancer. One or more of the previously mentioned conditions frequently cause these symptoms. However, those who do indeed have prostate cancer and are unaware of it experience these symptoms. That's why it's important to do a PSA test as soon as you start to experience one or more of the symptoms presented in this article. If your PSA levels are slightly higher, your doctor might take you through other types of tests to determine if you really have prostate cancer or not. Most patients don't, so don't get scared right away. If your PSA levels are very high and other tests indicate that your prostate might be cancerous, it's best to discover it as soon as possible, right? Your doctor might recommend various treatment methods to help you keep your PSA levels under control. In any case, it's very important to do a PSA test, especially if you're older and experience recurring pelvic pain or discomfort while urinating. Free PSA vs. Regular PSA Test When PSA levels are elevated, free PSA can be used as a marker to help determine if prostate cancer is a possibility. Free PSA is the amount of PSA in the blood that is not bound to other proteins. A low percentage of free PSA may indicate a higher likelihood of aggressive prostate cancer. An enlarged prostate, BPH, and certain medications can also cause high PSA levels. To confirm a diagnosis, additional tests may be needed beyond just a PSA test. Essential Tips for PSA Test Preparation Proper preparation before your PSA test is essential to ensuring accurate results. While the test itself is straightforward, there are certain steps you can take to help maximize the accuracy of your test results. Before your PSA test, it's important to inform your healthcare provider about any medications you are taking, as some medications can affect PSA levels. Your healthcare provider may advise you to temporarily stop taking certain medications before the test. Additionally, it's recommended to avoid sexual activity, ejaculation, and vigorous exercise for at least 24 hours before your PSA test, as these activities can temporarily increase PSA levels. Fasting is not typically required before a PSA test. Steps to Take Before Your Test Before your PSA test, there are several steps you can take to ensure accurate results: Inform your healthcare provider about any medications you are taking, as some medications can affect PSA levels. Avoid sexual activity, ejaculation, and vigorous exercise for at least 24 hours before your test, as these activities can temporarily increase PSA levels. It is not typically necessary to fast before a PSA test, but it's always a good idea to follow any specific instructions provided by your healthcare provider. Be prepared to provide a blood sample during your appointment. The blood sample will be used to measure the level of PSA in your blood. What to Avoid Prior to Your Test To ensure accurate results from your PSA test, it's important to avoid certain factors that can affect PSA levels: Avoid ejaculation and sexual activity for at least 24 hours before your test, as these activities can temporarily increase PSA levels. Refrain from vigorous exercise or activities that put pressure on the prostate gland, such as bicycle riding, as this can also affect PSA levels. Inform your healthcare provider about any medications you are taking, as some medications can affect PSA levels. Your healthcare provider may advise you to temporarily stop taking certain medications before the test. It's important to note that certain factors, such as an enlarged prostate (benign prostatic hyperplasia), can also cause elevated PSA levels. Your healthcare provider will take into consideration your individual risk factors and medical history when interpreting your PSA test results. Order Your PSA Test From DiscountedLabs Today! You might be happy to find out that prostate cancer screening, including the PSA screening test and urine test, for different types of prostate cancer diagnosis is much more affordable these days. Order your blood test for PSA screening from DiscountedLabs and get your test results back in just a few business days. You don't even need your doctor's approval; you just order the PSA test, offer a blood sample to a nearby clinic, and receive your test results back by email. Ideally, a small PSA test is used for men who have at least 10 years of life expectancy or are being evaluated for a metastatic prostate cancer diagnosis. In general, we recommend prostate cancer screening for men ages 55 to 69, unless a male has a higher risk of prostate cancer diagnosis (a family history, being of African American descent), in which case we screen at age 50. This aligns with guidelines from the U. The next step after a positive PSA level or rectal exam indicating possible prostate cancer is a biopsy. This is a test where the doctor takes a small amount of tissue from your prostate and sends it to a lab for testing. It’s the only way to be sure you have cancer. It has never been easier to check the health of your prostate, so order your PSA test today.