What is Adrenal Insufficiency and What are the Symptoms?

Adrenal insufficiency (AI) is a condition in which the adrenal glands do not produce adequate amounts of steroid hormones, primarily cortisol; but may also include impaired production of aldosterone (a mineralocorticoid), which regulates sodium conservation, potassium secretion, and water retention. Craving for salt or salty foods due to the urinary losses of sodium is common.

Addison's disease, , the auto-immune type of primary adrenal insufficiency, and congenital adrenal hyperplasia can manifest as adrenal insufficiency. If not treated, adrenal insufficiency may result in abdominal pains, vomiting, muscle weakness and fatigue, depression, low blood pressure, weight loss, kidney failure, changes in mood and personality, and shock (adrenal crisis).

Whatever the cause, adrenal insufficiency was invariably fatal until 1949, when cortisone was first synthesized, and glucocorticoid- replacement treatment became available. However, despite this breakthrough, the diagnosis and treatment of patients with the disorder remain challenging.

Adrenal Insufficiency (AI) Caused by Medications

A study conducted by the researchers at the University of Bologna analyzed over 8,000 cases of AI to identify the common causes of drug-associated AI and the changes that have occurred in the field over the past two decades. The researchers found that 97.5% of the cases were serious, and 41.1% required hospitalization.

The number of AI cases has increased over the years, with most of them being caused by steroids. The prevalence of these drugs has also increased over the years. In 2015, the number of cases involving monoclonal antibodies had reached 33%. Although the majority of these cases were caused by non-steroidal anti-inflammatory drugs, the researchers noted that over 70% of them were also on steroids.

What Lab Tests are Used to Initiate Diagnosis of Adrenal Insufficiency?

 Discounted Labs’ basic adrenal insufficiency panel includes cortisol, ACTH, and DHEA as a starting point. Depending on lab test results, physicians may choose to do an ACTH stimulation test, renin test, aldosterone test, potassium, sodium, and a CT scan of the adrenal glands. In order to check for Addison's Disease, the auto-immune type of primary adrenal insufficiency, labs should be drawn to check 21-hydroxylase autoantibodies.

Cortisol Blood Test

What is Cortisol?

Cortisol (hydrocortisone) is the most prominent glucocorticosteroid, and it is essential for the maintenance of several body functions. Like other glucocorticosteroids, cortisol is synthesized from the common precursor cholesterol in the zona fasciculata of the cortex of the adrenal gland. For the transport of cortisol in blood, about 90% of cortisol is bound to corticosteroid-binding globulin (CBG) and to albumin. Only a small amount of cortisol circulates unbound in blood and is free to interact with its receptors.

Functions of Cortisol

The most important physiological effects of cortisol are the increase in blood glucose levels (enhancement of gluconeogenesis, catabolic action) and its anti-inflammatory and immunosuppressive action.

Production of Cortisol in the Body

Synthesis and secretion of cortisol by the adrenal gland are controlled by a negative feedback mechanism within the hypothalamus-pituitary-adrenal cortex-axis. If the cortisol level is low, corticotropin-releasing hormone (CRH) is secreted by the hypothalamus, which causes the pituitary to release adrenocorticotropic hormone (ACTH). This stimulates the synthesis and secretion of cortisol by the adrenal gland. Cortisol itself acts in a negative feedback mechanism on the pituitary gland and the hypothalamus. In addition, stress is followed by increased cortisol secretion.

Cortisol Blood Levels During the Day

Serum cortisol concentrations normally show a diurnal variation. Maximum concentrations are usually reached early in the morning and then concentrations decline throughout the day to an evening level that is about half of the morning concentration; therefore, for interpretation of results, it is important to know the collection time of the serum sample.

What the Cortisol Test Can Help to Diagnose

The cortisol status of a patient is used to diagnose the function or malfunction of the adrenal gland, the pituitary, and the hypothalamus. Thereby, cortisol serum concentrations are used for monitoring several diseases with an overproduction (eg, Cushing syndrome) or underproduction (eg, Addison disease) of cortisol and for monitoring several therapeutic approaches (eg, dexamethasone suppression therapy in Cushing syndrome and hormone replacement therapy in Addison disease).

Factors that Affect Cortisol Blood Levels

Pregnancy, contraceptives, and estrogen therapy give rise to elevated cortisol concentrations. In samples from patients who have been treated with prednisolone, methylprednisolone, or prednisone, falsely elevated concentrations of cortisol may be determined. During metyrapone tests, 11-deoxycortisol levels are elevated. Falsely-elevated cortisol values may be determined due to cross-reactions. Patients suffering from 21-hydroxylase-deficiency exhibit elevated 21-deoxycortisol levels and this can also give rise to elevated cortisol levels.

The time of sample collection must be taken into account when interpreting results due to the cortisol secretion circadian rhythm. Severe stress can also give rise to elevated cortisol levels.

As with all tests containing monoclonal mouse antibodies, erroneous findings may be obtained from samples taken from patients who have been treated with monoclonal mouse antibodies or who have received them for diagnostic purposes. In rare cases, interference due to extremely high titers of antibodies to streptavidin and ruthenium can occur. The test contains additives, which minimize these effects.

The determination of cortisol in 24-hour urine is the method of choice for the detection of Cushing syndrome since cortisol excretion in urine is not subject to the diurnal rhythm of cortisol secretion.

Potential Interference for the Cortisol Test

This test may exhibit interference when the sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H, or coenzyme R). It is recommended to ask all patients who may be indicated for this test about biotin supplementation. Patients should be cautioned to stop biotin consumption at least 72 hours prior to the collection of a sample.

ACTH Test

What is Adrenal Corticotropic Hormone (ACTH)?

Adrenocorticotropic hormone is a hormone secreted in the anterior (front) pituitary gland in your brain.

The role of ACTH is to maintain appropriate levels of the stress hormone cortisol, which is released by the adrenal glands. Cortisol is our body’s natural alarm system. As our body’s primary stress hormone, it works with different parts of the brain to influence our fear, mood, and motivation.

Cortisol is best known for fueling the body’s “fight-or-flight” response in a crisis. But, cortisol also has a critical role in a variety of things the body does, like:

• Controlling the sleeping and waking cycle
• Boosting energy levels to better handle stress (and restore normal levels afterward)
• Influences how the body uses carbs, proteins, and fats
• Reducing inflammation
• Regulating blood pressure
• Increasing blood sugar

What Are the Symptoms of High or Low ACTH Induced Cortisol?

Symptoms of high cortisol can include; high blood pressure, obesity, high blood sugar levels, and edema. Low cortisol levels can cause weight loss, fatigue, low blood pressure, and muscle weakness.

What is the ACTH Test?

If you’re experiencing the symptoms of a cortisol imbalance, your doctor may order an ACTH test to measure the levels of both ACTH and cortisol in the blood . The ACTH test will help your doctor detect the diseases that are associated with too much or too little cortisol in the body. Your doctor might also perform a physical examination before making a firm diagnosis.

DHEA Test

Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal gland. It is also made in the brain. DHEA leads to the production of androgens and estrogens (male and female sex hormones). As almost all DHEA is derived from the adrenal glands, blood measurements of DHEA-S are useful to detect excess adrenal activity as seen in adrenal cancer or hyperplasia, including certain forms of congenital adrenal hyperplasia.

Although serum DHEA-S levels are low in patients with primary or central adrenal insufficiency, a low level of this steroid is not sufficient by itself for establishing the diagnosis. A normal age- and sex-adjusted serum DHEA-S level, however, practically rules out the diagnosis of adrenal insufficiency.

What is Amenorrhea?

Amenorrhea is the absence or abnormal cessation of the menses (menstruation periods).

Primary and secondary amenorrhea describe the occurrence of amenorrhea before and after menarche, respectively. The majority of the causes of primary and secondary amenorrhea are similar. Timing of the evaluation of primary amenorrhea recognizes the trend to earlier age at menarche and is therefore indicated when there has been a failure to menstruate by age 15 in the presence of normal secondary sexual development (two standard deviations above the mean of 13 years), or within five years after breast development if that occurs before age 10. Failure to initiate breast development by age 13 (two standard deviations above the mean of 10 years) also requires investigation. In women with regular menstrual cycles, a delay of menses for as little as one week may require the exclusion of pregnancy; secondary amenorrhea lasting three months and oligomenorrhea involving less than nine cycles a year require investigation.

Elevated FSH Levels

This 18 test anemia panel includes all tests needed to diagnose the degree and cause of anemia including a CBC panel (red blood cells, hemoglobin, etc), Ferritin, Iron, Total Iron Binding Capacity, Folate, and Vitamin B-12.

This lab test panel is ideal for people who feel fatigued and who may suspect anemia.  Women whose menstrual cycle is characterized by a lot of blood loss, people with potential vitamin deficiencies, and those who suspect internal bleeding will benefit from exploring the biomakers in this panel. Also, men and women who donate blood frequently  may find this panel useful to ensure that they have no depleted their iron, ferritin and other markers of iron stores that  can dramatically impact their energy level, mental function, mood and quality of life.

Anemia is a decrease in the total amount of red blood cells (RBCs) or hemoglobin in the blood, or a lowered ability of the blood to carry oxygen. It can have several causes.

Symptoms of Anemia

When anemia comes on slowly, the symptoms are often vague and may include feeling tired, weakness, shortness of breath, and a poor ability to exercise. When the anemia comes on quickly, symptoms may include confusion, feeling like one is going to pass out, loss of consciousness, and increased thirst. Anemia must be significant before a person becomes noticeably pale.

Causes of Anemia:

Anemia can be caused by blood loss, decreased red blood cell production, and increased red blood cell breakdown. Causes of blood loss include trauma and gastrointestinal bleeding.

Causes of decreased production include iron deficiency, vitamin B12 deficiency, thalassemia, and a number of neoplasms of the bone marrow. Causes of increased breakdown include genetic conditions such as sickle cell anemia, infections such as malaria, and certain autoimmune diseases.

Types of Anemia:

Anemia can also be classified based on the size of the red blood cells and amount of hemoglobin in each cell. If the cells are small, it is called microcytic anemia; if they are large, it is called macrocytic anemia; and if they are normal sized, it is called normocytic anemia.

Diagnosis of Anemia:

The diagnosis of anemia in men is based on a hemoglobin of less than 130 to 140 g/L (13 to 14 g/dL); in women, it is less than 120 to 130 g/L (12 to 13 g/dL).

Anemia Tests Included:

CBC (Complete Blood Count) Panel:

Complete Blood Count

 Whole blood is made up of various types of cells suspended in a liquid called plasma. The complete blood count (CBC) is an inventory of the different cellular components of the blood: red blood cells, white blood cells, and platelets. Blood cell counts are typically reported as the number of cells in a cubic millimeter of blood (cells/mm3) or as a percentage of all blood cells.

 Red Blood Cells

 Red blood cells (erythrocytes) carry oxygen from the lungs to the body's cells, bound to a molecule called hemoglobin. Anemia is a condition characterized by a reduction in the number of red blood cells, often leaving a person fatigued, weak, and short of breath. Several tests are used to help diagnose various types of anemia.

 Red Blood Cell Count (RBC): the total number of red blood cells in a quantity of blood. Normal ranges are 4.5-6.0 million cells/mm3 for men and 4.0-5.5 million cells/mm3 for women. (Women typically have lower counts than men due to the loss of blood through menstruation.)

 Hematocrit (HCT): the proportion of red blood cells as a percentage of total blood volume. A normal hematocrit is 40-55% for men and 35-45% for women.

 Hemoglobin (HGB): the number of grams of hemoglobin in a deciliter of blood (g/dL). Normal levels in healthy adults are 14-18 g/dL for men and 12-16 g/dL for women. As a rough guideline, hemoglobin should be about one-third the hematocrit.

 Mean Corpuscular Hemoglobin (MCH) and MCH Concentration (MCHC): the amount or concentration, respectively, of hemoglobin in an average red blood cell.

 Mean Corpuscular Volume (MCV): the average size, or volume, of individual red blood cells. Conditions such as iron deficiency can lead to smaller than normal red blood cells, while certain vitamin deficiencies and some drugs can produce larger than normal cells.

 Red Blood Cell Distribution Width (RDW): a measure of the size and uniformity of red blood cells.

 White Blood Cells

White blood cells (leukocytes) carry out the body's immune responses. The CBC looks at numbers of various different types of white blood cells.

 White Blood Cell Count (WBC): the total number of white blood cells in a quantity of blood. A healthy adult normally has 4,000-11,000 white blood cells/mm3. A WBC increase often indicates that a person is actively fighting an infection or has recently received a vaccine. Decreased WBC (leukopenia) can leave a person vulnerable to various pathogens and cancers.

 Differential: a report of the proportions of different types of white blood cells as a percentage of the total number of white cells; these percentages may be multiplied by the WBC to obtain absolute counts.

 Neutrophils: a type of cell that fights bacterial infections. Neutrophils normally make up about 50-70% of all white blood cells. The risk of bacterial infection increases when the absolute neutrophil count falls below about 500-750 cells/mm3.

 Lymphocytes: there are two main types of lymphocytes. B cells produce antibodies that fight foreign invaders in the body, while T cells target infected or cancerous cells and help coordinate the overall immune response. A normal lymphocyte count is about 20-40% of all white blood cells.

 Monocytes: a type of cell that fights pathogens by engulfing and destroying them. Monocytes circulate in the blood for about 24 hours; when they leave the bloodstream and migrate into the tissues, they mature into macrophages. Monocytes and macrophages normally account for 2-10% of all white blood cells.

 Eosinophils: cells that play a role in defense against parasites and in allergic reactions. They normally make up 0-6% of all white blood cells.

 Basophils: another type of cell involved in allergic reactions, in particular the release of histamine. They normally account for 1% or less of all white blood cells.

Platelets

 Platelets (thrombocytes) are necessary for blood clotting. A normal platelet count is about 130,000-440,000 cells/mm3. Low platelet counts (thrombocytopenia) -- which can lead to easy bruising and excessive bleeding -- may be caused by certain drugs, autoimmune reactions, accelerated destruction by the spleen, or certain immune diseases.

Folic Acid:

B12 and folic acid blood testing help doctors diagnose central nervous system disorders, anemia, and malabsorption syndromes. B12 and folic acid also play an important role in energy level, muscle strength and memory. Because B12 and folate are derived solely from dietary intake, such as egg yolks, beef, poultry and fish, many people are deficient in these important vitamins.

Vitamin B-12 Level:

Vitamin B-12 is an essential vitamin. Low blood levels of B12 can cause: Anemia and pernicious anemia, loss of balance , numbness or tingling in the arms and legs, and weakness

Iron & TIBC:

The serum iron test measures the amount of iron in your blood. The total iron-binding capacity (TIBC) test looks at how well the iron moves through your body. Iron is an important mineral that your body needs to stay healthy. Your body uses iron to make hemoglobin, the protein in your red blood cells that carries oxygen throughout your body. If you don't have enough iron, you may not have enough hemoglobin. This condition is called iron deficiency anemia. Iron in your body is carried, or bound, mainly to a protein made by your liver called transferrin. The TIBC test is based on certain proteins, including transferrin, found in the blood. Your transferrin levels are almost always measured along with iron and TIBC. 

Ferritin:

Ferritin is a protein found in the bloodstream which stores iron. Ferritin helps in transporting iron where it's most needed in the body. Too much or too little ferritin can cause a lot of health issues and that's why you should check it often.  The levels of ferritin in the body are different for men and women. For example: - Men - 24 - 500 ng/ml of blood - Women - 22 -200 ng/ml of blood. However, many people may have anemia symptoms at the lower end of the "normal" range.

IMPORTANT: Discounted Labs only serves these states: Find a Location 

DiscountedLabs.com offers affordable blood tests you can order online in the United Sates without the need of a doctor's order. We have no hidden fees and have an easy ordering process.

HOW DOES DISCOUNTEDLABS.COM WORK?

1. Go to the "Find a Location" page to find the closest lab location. No need to make an appointment since walk-ins are welcomed. Once you have identified your closest location, go to step 2.

   NOTE: We serve all states in the U.S. except New York, New Jersey, and Rhode Island. Residents of those states need a written lab order from an in-state provider. Individuals cannot obtain a blood draw in neighboring states.

2. Go to "Choose a Test" and add your selection (s) in the shopping cart. If you prefer to save money on bundled tests, we have created "Lab Test Panels" that can help you decide what to order.

3. If you have a discount coupon code, add it to your cart.

4. A $8 lab processing fee will be added to your total.

5. Pay using a credit card.

6. You will receive an order confirmation and instructions email on how to download your lab request.

7. Print lab request form that you downloaded.

8. Take that form to the closest location with a picture ID. Get your blood drawn.

9. You will receive an email when the results are ready for you to download.

   Note: You cannot place an order under someone else's profile. The profile person's name will appear on the lab order form.

   If you have questions, please review our FAQ Page.

   If you have further questions, please email [email protected].

Annual physical exams are an essential part of preventive healthcare. These routine check-ups aim to monitor the overall health, identify potential health issues early, and establish baselines for personalized healthcare. A fundamental component of these annual exams involves laboratory tests, which provide physicians with a detailed understanding of a patient's bodily functions. This article explores the most common lab tests included in this panel, namely: CBC (Complete Blood Count), CMP (Comprehensive Metabolic Panel), Lipid Profile, A1C, TSH (Thyroid-Stimulating Hormone), and Urinalysis.

Complete Blood Count (CBC)

The Complete Blood Count (CBC) test is a broad screening test used to assess the overall health and detect a wide range of disorders such as anemia, infection, and leukemia.

Importance of CBC

A CBC measures various components and features of your blood, including red blood cells, which carry oxygen; white blood cells, which fight infection; and platelets, which help blood to clot. Variations in these components can indicate numerous health conditions, which is why this test forms a fundamental part of the annual exam.

Comprehensive Metabolic Panel (CMP)

The Comprehensive Metabolic Panel (CMP) is a group of 14 blood tests that provide an overview of the body's chemical balance and metabolism.

Importance of CMP

A CMP typically includes tests for blood sugar (glucose) levels, electrolyte and fluid balance, kidney function, and liver function. The results can help diagnose conditions like diabetes, kidney disease, and liver disease, among others.

Lipid Profile

The lipid profile is a group of tests used to determine the risk of coronary heart disease.

Importance of Lipid Profile

This panel measures the amount of cholesterol and triglycerides in your blood. High levels of these can lead to atherosclerosis, a condition that increases the risk of heart disease and stroke. Regular monitoring can help manage these levels and prevent associated diseases.

Hemoglobin A1C

The A1C test provides a picture of your average blood sugar (glucose) control for the past 2 to 3 months.

Importance of A1C

This test is particularly crucial for people with diabetes, but it's also used for diagnosis in at-risk individuals. A high A1C level is a risk factor for diabetes and can indicate issues with blood sugar control in diagnosed patients.

Thyroid-Stimulating Hormone (TSH)

TSH tests evaluate how well your thyroid is working and are usually done if you have symptoms of a low or high thyroid hormone level.

Importance of TSH

The thyroid gland plays a vital role in the body's metabolic processes. Variations in TSH can lead to conditions such as hypothyroidism (low thyroid function) or hyperthyroidism (overactive thyroid). Regular TSH tests can help in early detection and management of these conditions.

Urinalysis

Urinalysis is a test that assesses the urine and is typically used to detect diseases of the urinary system and metabolic diseases, such as diabetes.

Importance of Urinalysis

Urinalysis can reveal substances in the urine not normally present, such as glucose, protein, red blood cells, and white blood cells. It can help in detecting conditions such as urinary tract infections, kidney disease, or diabetes.

In conclusion, annual physical exams are a crucial part of health maintenance, and laboratory tests are an integral component of these exams. Each test provides valuable information about various bodily functions, enabling early detection, prevention, and treatment of many health conditions.

This annual physical panel contains: 

• CBC (Complete Blood Count: Immune Cells, Red Blood Cells/Hematocrit, and Platelets)
• CMP (Comprehensive Metabolic Panel: Glucose, liver and kidney function, electrolyte and fluid balance)
• Lipids (LDL and HDL Cholesterol, and Triglycerides)
• A1c (Glycated Hemoglobin)

What Are Common Lab Tests Included in an Annual Physical Doctor Visit?

This annual physicial lab test panel includes the basic blood tests usually included in an annual physical exam for men and women who are healthy and have no underlying conditions:

• CBC (Complete Blood Count: Immune Cells, Red Blood Cells/Hematocrit, and Platelets)
• CMP (Comprehensive Metabolic Panel: Glucose, liver and kidney function, electrolyte and fluid balance)
• Lipids (LDL and HDL Cholesterol, and Triglycerides)
• A1c (Glycated Hemoglobin)

Complete Blood Count (CBC test)

 Whole blood is made up of various types of cells suspended in a liquid called plasma. The complete blood count (CBC) is an inventory of the different cellular components of the blood: red blood cells, white blood cells, and platelets. Blood cell counts are typically reported as the number of cells in a cubic millimeter of blood (cells/mm3) or as a percentage of all blood cells.

Comprehensive Metabolic Panel (CMP test)

The comprehensive metabolic panel or cmp panel consists of 14 blood tests which serve as an initial medical screening tool to review overall health. The CMP blood test panel functions as a check for kidney function, liver function, and electrolyte and fluid balance. 

Lipid Panel (Cholesterol Test)

The lipid panel valuates the risk for developing atherosclerosis (arterial plaque) and coronary heart disease. This test includes: Total Cholesterol, Triglycerides , HDL Cholesterol, LDL Cholesterol, Total Cholesterol/HDL Ratio. This test requires fasting for 8 hours.

A1C Test (Glycated Hemoglobin)

The A1c test works by measuring the hemoglobin A1c level. Hemoglobin is stored in the red blood cells. When glucose levels are high, the sugar starts to combine with the hemoglobin. It takes the body 8 to 12 weeks to bring hemoglobin A1c levels back to normal. Therefore, if hemoglobin A1c levels are high, that means that there has been a high level of glucose in the blood over the last 2 to 3 months.

IMPORTANT: Discounted Labs only serves these states: Find a Location 

DiscountedLabs.com offers affordable blood tests you can order online in the United Sates without the need of a doctor's order. We have no hidden fees and have an easy ordering process.

HOW DOES DISCOUNTEDLABS.COM WORK?

1. Go to the "Find a Location" page to find the closest lab location. No need to make an appointment since walk-ins are welcomed. Once you have identified your closest location, go to step 2.

2. Go to "Choose a Test" and add your selection (s) in the shopping cart. If you prefer to save money on bundled tests, we have created "Lab Test Panels" that can help you decide what to order.

3. If you have a discount coupon code, add it to your cart.

4. A $8 lab processing fee will be added to your total.

5. Pay using a credit card.

6. You will receive an order confirmation and instructions email on how to download your lab request.

7. Print lab request form that you downloaded.

8. Take that form to the closest lab location with a picture ID. Get your blood drawn.

9. You will receive an email when the results are ready for you to download.

   Note: You cannot place an order under someone else's profile. The profile person's name will appear on the lab order form.

    

   If you have further questions, please email [email protected].

What is ANA Screen IFA W/Refl Titer and Pattern?

Have you ever been asked to take an ANA Screen IFA Titer and Pattern test and wondered what it is all about? ANA Screen tests are conducted to diagnose autoimmune disorders that affect the body's immune system. The test measures the level of antibodies that attack healthy cells in the body and produce a specific pattern under a microscope. In this blog, we will dive deep into ANA Screen IFA Titer & Pattern tests and answer all your questions. We will explain when and why you might need to take this test, how to prepare for it, and what to expect during the procedure. We will also discuss how to interpret abnormal results and the implications they carry for autoimmune patients. So, join us in understanding this essential diagnostic tool that can help detect autoimmune disorders early on.

Understanding ANA Screen IFA Titer and Pattern

ANA Screen IFA Titer and Pattern is a diagnostic tool used to detect autoimmune diseases by measuring the concentration of antinuclear antibodies (ANA) in the blood. The pattern of ANA can provide valuable clues about the specific autoimmune disease present. This test plays a crucial role in the diagnosis and management of autoimmune disorders, helping healthcare providers evaluate patients suspected of having these conditions. By analyzing the pattern and titer of ANA, healthcare professionals can identify potential autoimmune diseases such as systemic sclerosis, polymyositis, dermatomyositis, and autoimmune hepatitis. These lab tests are essential in assessing organ inflammation and identifying target substances that may be attacking the body's own cells. Analyzing the ANA Screen IFA Titer and Pattern is a key component of a comprehensive physical examination, aiding in the detection of autoimmune disorders in patients presenting with symptoms like skin rashes, joint pain, and gland inflammation.

ANA Screen: Autoimmune Antibodies

The ANA Screen is a test that measures the presence of autoimmune antibodies in the blood, which can indicate the presence of an autoimmune disease. ANA stands for antinuclear antibodies, and these are proteins that attack the body's own cells. The test measures the titer and pattern of these antibodies to help diagnose conditions such as lupus, rheumatoid arthritis, and Sjögren's syndrome. It is important to note that a positive ANA Screen does not necessarily mean that a person has an autoimmune disease; rather, it is one factor in making a diagnosis along with other clinical observations.

Importance of IFA Titer and Pattern in an ANA Screen

The concentration of antinuclear antibodies (ANA) in the blood can be measured using the IFA titer. A higher titer indicates a greater concentration of ANA antibodies. The pattern of ANA, such as homogeneous, speckled, nucleolar, or centromere, can provide valuable information about the specific autoimmune disease. By combining the titer and pattern, healthcare providers can make accurate diagnoses and determine appropriate treatments for autoimmune diseases. This information helps in identifying conditions like lupus, rheumatoid arthritis, scleroderma, polymyositis, dermatomyositis, and autoimmune hepatitis. Overall, the IFA titer and pattern play a crucial role in the diagnostic process, enabling targeted management of various autoimmune disorders.

When and Why is an ANA Screen Test Required?

An ANA screening test becomes necessary when a patient presents symptoms of an autoimmune disease. It helps confirm or rule out the presence of autoimmune disorders and assess disease activity. Joint pain, muscle pain, a rash, swelling, or a family history of autoimmune diseases may prompt the test.

Identifying Autoimmune Disorders

The ANA Screen test is a valuable tool in identifying various autoimmune disorders. It can detect conditions such as systemic lupus erythematosus (SLE), rheumatoid arthritis, scleroderma, mixed connective tissue disease, and Sjögren’s syndrome. By analyzing the presence of specific antibodies, healthcare professionals can gain insights into the type of autoimmune disorder a patient may have. Early detection and diagnosis of these disorders are crucial for timely treatment and management. Detecting autoimmune disorders through the ANA Screen test allows for targeted interventions to address organ inflammation, inflammation of glands, and other manifestations associated with these conditions.

How does an ANA Screen Test help in Diagnosis?

The ANA Screen test plays a crucial role in diagnosing autoimmune diseases. By detecting autoantibodies attacking healthy cells, it helps healthcare providers narrow down the diagnosis. Positive results prompt further evaluation, allowing for timely intervention and improved patient outcomes.

The Procedure of an ANA Screen IFA Titer and Pattern Test

The ANA Screen IFA Titer & Pattern test starts with the collection of a blood sample, which is then examined by a lab technician using immunofluorescence. During the analysis, the technician looks for the fluorescence pattern to determine the ANA titer and pattern. This test is typically conducted in a healthcare setting or laboratory. Before the test, patients need to follow specific preparation steps. The ANA Screen IFA Titer & Pattern test plays a crucial role in identifying autoimmune disorders like systemic lupus erythematosus (SLE), rheumatoid arthritis, and scleroderma, among others.

Test Preparation

To ensure proper test preparation for an ANA Screen IFA Titer and Pattern, there are a few important steps to follow. First, it is generally not necessary to fast before the test. However, it is crucial to inform your healthcare provider about any medications or supplements you are currently taking. Additionally, wearing loose-fitting clothes can make it easier for healthcare professionals to draw blood. It's essential to follow any specific instructions provided by your healthcare provider. Finally, try to relax and stay calm before the test to minimize discomfort.

What to Expect During the Test?

During an ANA Screen test, a healthcare professional will extract a blood sample from your vein. You may experience a slight prick or stinging sensation when the needle is inserted. The sample will then be sent to a lab for analysis. The procedure typically takes a few minutes, and afterwards, you can resume your normal activities without any restrictions.

Interpreting the Results of an ANA Screen Test

A positive result from an Ana screen ifa w/refl titer and pattern indicates the presence of antinuclear antibodies (ANA) in the blood. The titer, or concentration, of ANA, and the pattern observed help in interpreting the results. A higher titer suggests a greater concentration of ANA in the blood, which may indicate a more significant autoimmune response. Additionally, different patterns of ANA can provide valuable insights into specific autoimmune diseases. It's important to note that a negative result does not completely rule out autoimmune diseases, and further testing may be necessary to confirm a diagnosis.

Understanding IFA Titer and its Significance

The IFA titer is a measure of the concentration of antibodies in the blood, indicating the strength of the immune system's response. Higher IFA titers suggest a more active immune response, while a low titer may indicate a lower likelihood of autoimmune disease. Regular monitoring of IFA titers can help track disease activity over time. It is important to understand the significance of IFA titers in assessing the immune system's capability to fight against invaders and determining the presence or absence of autoimmune diseases.

Comprehending ANA Screen Patterns

ANA screen patterns offer valuable insights into the presence of specific autoantibodies in the bloodstream. These patterns can vary and provide clues about different autoimmune diseases. For instance, a homogeneous pattern might suggest the possibility of systemic lupus erythematosus (SLE), while a speckled pattern could indicate mixed connective tissue disease (MCTD). On the other hand, a nucleolar pattern is commonly associated with scleroderma and other connective tissue diseases. By comprehending these ANA screen patterns, healthcare professionals can better diagnose and understand the underlying autoimmune conditions that individuals may be facing.

What are the Implications of Abnormal ANA Screen Results?

Abnormal ANA screen results can suggest the presence of an autoimmune disease, but a positive result doesn't always mean a person has one. Further tests are needed to confirm the type and presence of an autoimmune disease. Abnormal results may lead to additional testing or referral to a specialist, while a negative result doesn't rule out the possibility of an autoimmune disease.

How can an ANA Screen Test be Beneficial for Autoimmune Patients?

The ANA screen test offers several benefits for autoimmune patients. It helps in diagnosing and monitoring autoimmune diseases, allowing for early intervention and timely treatment decisions. Regular screening aids in tracking disease progression and evaluating treatment effectiveness, providing valuable information for managing the quality of life of autoimmune patients.

Frequently Asked Questions

Should I use this test when being tested for possible lupus or scleroderma?

ANA Screen IFA Titer & Pattern is a blood test used to diagnose autoimmune diseases like lupus and scleroderma. It detects antibodies that attack healthy cells. A positive result doesn't confirm the disease, requiring further testing. Discuss your results with a healthcare professional for appropriate treatment options.

Has anyone else had positive abnormal ANA blood tests?

Positive abnormal ANA blood tests are not uncommon. While they are often used to diagnose autoimmune diseases, a positive result doesn't necessarily mean you have one. Consult with a healthcare professional for further evaluation and testing to determine the underlying cause.

What does a positive result for ANA Screen IFA w/Reflex Titer and Pattern mean?

A positive result for the ANA Screen IFA w/Reflex Titer and Pattern indicates the presence of antinuclear antibodies in the blood. This can be a sign of an autoimmune disease, although further testing is needed to determine the cause. Remember, a positive result doesn't necessarily mean you have an autoimmune disease.

How is ANA Screen IFA w/Reflex Titer and Pattern used in the diagnosis of autoimmune diseases?

The ANA Screen IFA w/Reflex Titer and Pattern is a blood test that helps detect autoimmune diseases by measuring antibody levels in the blood. The titer indicates the concentration of antibodies, while the pattern identifies specific autoimmune diseases. A positive result should be confirmed with further testing.

What are some common conditions associated with a positive result for ANA Screen IFA w/Reflex Titer and Pattern?

Conditions such as lupus, rheumatoid arthritis, and Sjogren's syndrome are commonly associated with a positive ANA Screen IFA result. However, it's important to note that a positive result doesn't necessarily mean the presence of an autoimmune disease. Healthcare providers evaluate medical history and other test results for further diagnosis and treatment.

How accurate is ANA Screen IFA w/Reflex Titer and Pattern in diagnosing autoimmune diseases?

The accuracy of the ANA Screen IFA w/Reflex Titer and Pattern test in diagnosing autoimmune diseases varies depending on factors like symptoms and medical history. While a positive result may indicate an autoimmune disease, further tests and assessments are needed for a definitive diagnosis.

Can medications or other factors affect the results of ANA Screen IFA w/Reflex Titer and Pattern Testing?

Certain factors, including medications and medical conditions, can influence the outcomes of ANA Screen IFA testing. Medications like blood pressure medication and antibiotics may cause false positive results, while conditions such as lupus and rheumatoid arthritis can lead to a positive ANA test. Inform your healthcare provider about any medications or medical conditions before taking the test.

Is further testing needed if the results of ANA Screen IFA w/Reflex Titer and Pattern are positive?

Further testing is required if the ANA Screen IFA w/Reflex Titer and Pattern results come back positive. Positive ANA results can indicate autoimmune disorders, but additional tests like anti-dsDNA or anti-Smith antibodies may be needed to confirm a diagnosis. Consult with a healthcare professional for more information and necessary follow-up testing.

Conclusion

In conclusion, understanding the ANA screen IFA titer and pattern is crucial for diagnosing and monitoring autoimmune disorders. The ANA screen test helps identify the presence of autoantibodies in the bloodstream, which indicate an immune system dysfunction. The IFA titer provides information about the concentration of these antibodies, while the pattern reveals the specific antigens targeted by the autoantibodies. Interpreting the results correctly is essential for an accurate diagnosis and guiding further medical interventions. For individuals with abnormal ANA screen results, it is important to consult with a healthcare professional to determine the appropriate course of action. Regular ANA screen tests can be beneficial for autoimmune patients, as they help track disease progression and monitor treatment effectiveness.

References:

Autoimmune Diseases: Signs, Symptoms, and Complications

Autoimmune Diseases: Types, Symptoms, Causes & More

Antinuclear Antibody (ANA) Test

ANA (Antinuclear Antibody) Test: MedlinePlus Medical Test

This blood donation panel includes these tests: Hematocrit, iron & total iron binding capacity (TIBC), and ferritin.

This panel is designed to determine if:

1- Your blood donation or therapeutic phlebotomy was effective in lowering your high hematocrit without negatively affecting ferritin or iron.

2- It is safe to do another blood donation or therapeutic phlebotomy depending on ferritin or iron levels.

What is Hematocrit?

Hematocrit is the portion of blood made up of red blood cells.

High hematocrit occurs when there is an excessive production of red blood cells. High hematocrit can cause the blood to become very viscous or "sticky," making it harder for the heart to pump. High blood pressure, strokes and heart attacks can occur.

Testosterone Therapy and High Hematocrit

The association between testosterone replacement therapy and high hematocrit has been reported for the past few years as this therapy has become more mainstream. In addition to increasing muscle and sex drive, testosterone can increase the body's production of red blood cells. This hematopoietic (blood-building) effect could be a good thing for those with mild anemia.

Although all testosterone replacement products can increase the number of red blood cells, the study showed a higher incidence of higher hematocrit in those using intramuscular testosterone than topical administration (testosterone patch was the main option used -- no gels). Smoking and sleep apnea have also been associated with polycythemia and may contribute to the effects of other risk factors like TRT.

It's important to check patients' hemoglobin and hematocrit blood levels while on testosterone replacement therapy. As we all know, hemoglobin is the substance that makes blood red and helps transport oxygen in the blood. Hematocrit reflects the proportion of red cells to total blood volume. A hematocrit of over 52 percent should be evaluated. Decreasing testosterone dose or stopping it are options that may not be the best for assuring patients' best quality of life, however. Switching from injectable to transdermal testosterone may decrease hematocrit, but in many cases not to the degree needed.

Different medical guideline groups that recommend monitoring for testosterone replacement therapy agree about measuring hematocrit at month 3, and then annually, with some also recommending measurements at month 6 after starting testosterone.

How to Lower Hematocrit with Blood Donations- Warning

Many patients on testosterone replacement who experience polycythemia do not want to stop the therapy due to fears of re-experiencing the depression, fatigue and low sex-drive they had before starting treatment. For those patients, blood donation or therapeutic phlebotomy may be the answer. Therapeutic phlebotomy is very similar to what happens when donating blood, but this procedure is prescribed by physicians as a way to bring down blood hematocrit and viscosity when blood centers refuse to accept a blood donor because of his high hematocrit.

When donating blood, usually a unit of blood is extracted from the body. For every unit of blood donated or extracted through therapeutic phlebotomy, there is a 2-3 point decrease in hematocrit. If your hematocrit is 56 and you want to bring him under 50, you would have to give 2 to 3 units of blood. However, taking this much blood out in one single blood donation/phlebotomy session may deplete ferritin and iron levels which can cause extreme fatigue. So, be conservative and only give 1 unit max even if you have to go more frequently. But be aware that the Red Cross has stated that blood donations done more frequently than every 2.5 months run the risk of lowering your ferritin and iron too much (which can cause fatigue), so make sure that you get a ferritin test to determine if you should take an iron supplement after donating or to make sure that ferritin is not low before the next blood donation.  It is estimated that one unit of blood extracted can lower ferritin by 30 points.  Ferritin levels under 45 have been linked to fatigue and other symptoms.

Blood ABO Grouping and Rh Typing - Everything You Need to Know

Although blood has its unique red color, its chemistry can be varied from individual to individual. Some people have a certain type of blood and they cannot receive blood transfusions from people with who they are not compatible.

The blood typing or grouping is dictated by certain antibodies called antigens. These antigens are present on the surface of red blood cells or other tissues in the body. Keep reading to learn more about ABO grouping, Rh typing, and why they are important.

What Is ABO Grouping and Rh Typing?

Scientists have discovered more than 40 different types of blood in the human body. However, some of them are prevalent to most people, so we'll focus on them. For example, the 4 main types of blood are A, B, AB, and O.

This type of grouping or blood system is created based on the antigens present on the surface of red blood cells. People who have type A blood have the A antigen; people who have type B blood have the B antigen. Similarly, people who have type AB blood have both A and B antigens, and finally, people with type O blood have no antigens at all.

The Rh typing also comes into play here. Blood types can have 2 Rh options - positive or negative. Rh-positive blood has a specific antibody present on the red blood cells. Rh-negative blood doesn't have this antibody.

Delivering the wrong type of blood to a person can pose serious complications. There is a risk of blood clumping and agglutination. These conditions can be life-threatening as they tend to damage most of the tissues and organs in the body of the recipient.

How Does Blood Compatibility Work?

The immune system of each individual is capable of identifying the specific antigens present on the red blood cells. Blood compatibility is important when it comes to blood transfusions because if someone gets the wrong type of blood, his/her immune system starts to develop antibodies against it.

For example:

• Type A people can receive from other people with type A blood or from people with type O. They can donate blood to people with type A and/or type AB blood
• Type B people can receive from other people with type B blood or from people with type O. they can donate blood to people with type B and/or type AB blood
• Type AB people can receive blood from anyone but they can only donate blood to other type AB individuals
• Type O people can receive blood only from other individuals with type O. They can donate to everyone since their blood has no specific antigen present on red blood cells

Additionally, blood transfusions are also dictated by the Rh factor. For example:

• Rh-positive people can receive blood from other individuals with Rh-positive blood or people with Rh-negative blood
• Rh-negative people can only receive blood from other individuals with Rh-negative blood typing. They can safely donate to either Rh-negative or Rh-positive people

As you can see, there are 8 main types of blood out there if you consider the blood-specific antigen and the Rh factor. That's why it's important to know your blood type, so you know your compatibility in case of transfusions or medical emergencies.

When it comes to blood grouping distribution, about 38% of the US population is type O positive and 7% is type O negative. 34% percent is type A positive and just 6% is type A negative. The other blood groupings are small percentages, but these statistics are constantly changing over the years.

Type O blood is always a priority for blood banks and hospitals because this type of blood is the most prevalent. There is always someone who needs type O blood on a hospital bed. More specifically, Rh-negative type O blood is a universal donor as it can be transfused to everyone without the risk of harming recipients.

On the other hand, having Rh-positive type AB blood makes you a very lucky person. You can receive blood from anyone without damaging your system. This is called the universal recipient type of blood and only about 3% of people in the United States have it.

Why Is It Important to Know Your Blood Type?

There are multiple reasons why you should know your blood type. This is vital information that's inexpensive to find out. Here are some of these reasons:

Know Your Blood Donation Compatibility

Hospitals are almost always in great demand of blood, particularly those types that are difficult to find such as Rh-negative blood. If you get the chance and you're able, you should donate blood once per year.

Every blood bag is labeled and stored accordingly by hospitals and blood banks. This blood is useful during surgeries or for blood transfusions. If you know your blood type, you are more aware of how prevalent or how scarce it can be.

Know the Transfusion Compatibility

Knowing your blood type also helps with identifying possible donors or receivers in a specific circle of friends or among your family members. Remember that there are 8 different blood types out there if you consider the Rh factor.

If you have a particularly rare type of blood, it's good to know so you can find potential donors on time. Your body cannot receive blood from anyone and knowing the transfusion compatibility saves a lot of time and headaches.

For example, if a person receives incompatible blood, his or her immune system will start to develop antibodies to the antigens of the received blood. This is basically doing more harm than good. Blood transfusions are frequent during surgeries and a lot of complications can arise if the wrong type of blood is administered.

Similarly, if you ever need a blood transfusion, it's nice to know that you're compatible with someone in your family or circle of friends. In case of emergency, you can be the recipient or donor of blood to save someone's life or yours.

It's Useful for Pregnant Women

Although it rarely happens, some mothers might be Rh-negative and give birth to a Rh-positive baby. The baby inherits the positive antigen from a Rh-positive father. As a result, the mother's immune system might see the Rh positivity of the baby as a foreign substance and develop antibodies to it.

These antibodies could cross the placenta and cause massive damage to the internal organs and tissues of the newborn. This is called hemolytic disease and it can be prevented with the right treatment.

During pregnancy, doctors can do ABO grouping tests to determine if the mother and the baby are not blood compatible. If this is the case, doctors might choose to administer injections that protect the Rh antigen of the baby against the immune system of the mother.

These injections are administered throughout pregnancy and after giving birth. It will prevent hemolytic disease and other complications caused by having an incompatibility between the mother and the fetus.

Know Your Organ Donor Status

Not only blood can be put into another person's body, but also organs and/or tissues. In this case, there is also a compatibility issue and knowing your ABO grouping and Rh factor helps a lot. Doctors do a lot of tests to determine if a person is compatible with another before donating a portion of an organ.

For example, the liver is known to have amazing regenerative properties. It's possible to receive a liver transplant from someone else under certain conditions. However, the organ must be compatible with your body and your blood types must match too.

Apart from blood, organs, and tissues, bone marrow transplants are also popular and can be done successfully. Again, ABO grouping tests and other types of tests are required to determine the compatibility of bone marrow between the donor and the recipient.

How Can You Find Out Your Blood ABO Grouping?

Finding what type of blood, you have is done very easily with the help of a blood test. You can order a direct-to-consumer lab and go to a clinic to give a blood sample. The results are emailed back to you in a few days or even quicker.

It takes medical science just a few minutes to determine your ABO grouping and Rh factor. This information is useful for each individual to know his/her compatibility with family members, friends, and so on.

In case of an emergency, it's good to know that you can donate blood to your sister or you can receive it from your closest friend because your blood types are compatible. Also, you don't have to fast before testing your blood type and this makes it more convenient for the general public.

Find Your Blood Type Today!

For an accurate and inexpensive blood grouping test, go to DiscountedLabs.com and order the ABO grouping blood test. You earn reward points from purchasing from DiscountedLabs and you get the results back very quickly!

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This panel provides smart bodybuilders with information that can help minimize potential short and long-term side effects and risks. It includes gold standard tests that do not have interferences. This basic bodybuilder panel includes the following tests/panels:

Hematocrit Test: 

All androgens like testosterone and AAS can increase red blood cells and their proportion in the blood (hematocrit), increasing blood thickness.  This panel is essential since it determines when you reach a hematocrit of 53, the value indicating that blood donation or therapeutic phlebotomy is needed. High hematocrit increases blood thickness which can cause high blood pressure, headaches, and cardiovascular risks.

Comprehensive Metabolic Panel (CMP)

A CMP lab test is used to evaluate several body processes and functions, including:

• Liver and kidney health
• Blood sugar levels
• Blood protein levels
• Acid and base balance
• Fluid and electrolyte balance
• Metabolism (glucose)
• Side effects of some medications

Fasting is required.

Testosterone, Total, LC/MS, and Free (Equilibrium Ultrafiltration) (No Upper Limit and No Interference with Anabolics)

This panel includes total testosterone measured by the most accurate method (LC/MS: liquid chromatography/mass spectrometry), free testosterone percent by equilibrium ultrafiltration, and free testosterone calculated from percent free T. No upper limit, so it is adequate for men on high testosterone or AA doses. The LC/MS assay also prevents interference of anabolics and biotin on testosterone blood levels.  Note: This test panel is the most accurate and does not get affected by the presence of anabolics in the blood, unlike the regular ECLIA-based testosterone test used by doctors not educated on laboratory assay differences.

Estradiol , Ultra Sensitive (LC/MS) Blood Test (Gold Standard Test for Men)

The commonly used estradiol test may overestimate estradiol. That test uses immunoassay technology that cannot differentiate C-Reactive Protein (involved in inflammation) from estradiol, so it reads the combination of the two as estradiol. This ultrasensitive estradiol test is based on liquid chromatography/mass spectrometry (LC/MS), an assay technology that does not have that limitation. Please be aware that estradiol is important in men and that treating it aggressively may get in the way of gains.

Cystatin C with EGFR Kidney Test (The Most Accurate Kidney Test for Bodybuilders)

Cystatin C is much more accurate than a plain CMP to determine kidney function in people with higher muscle mass since using only creatinine as the main variable can give your doctor an impression of kidney issues.  Unlike the commonly used creatinine test, Cystatin C is unaffected by higher muscle mass, protein intake, and creatine supplementation. Another one of the measures of kidney function is the estimated glomerular filtration rate (eGFR). The glomerular filtration rate describes the flow rate of filtered fluid through the kidney. Creatinine clearance rate (C_Cr or CrCl) is the volume of blood plasma cleared of creatinine per unit of time and is a helpful measure for approximating the GFR. eGFR under 60 may indicate issues that are affecting kidney function.

Lipid Test Panel

This panel includes LDL (bad cholesterol), HDL (good cholesterol), and triglycerides (fatty acids dissolved in the blood).  A higher dose of T and AAS can increase LDL and decrease HDL and triglycerides. Severely decreased HDL may cause cardiovascular issues in the long term. Fasting is required.

For a more comprehensive bodybuilder panel, check this one out: Comprehensive Bodybuilder Panel

Also, look at the Post Cycle Therapy panel

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Tests included: Hematocrit, Lipid panel (LDL, HDL, triglycerides), Cystatin C kidney test, eGFR kidney test, GGT liver test, Total Testosterone (LC/MS), Free Testosterone (Equilibrium Ultrafiltration), Ultrasensitive Estradiol, Prolactin, DHT test (LC/MS), IGF-1 test (LC/MS), and ferritin.

A Smart Bodybuilder Monitors His Lab Tests for Long Term Gains

If you are a bodybuilder using anabolic androgenic steroids (AAS), it's vital to be aware of the potential side effects. However, many athletes overlook the necessity of lab tests to maximize benefits and to detect these damaging effects early on to minimize potential risks. To guarantee that you remain healthy during on-cycle phases, regular lab tests are recommended to monitor your body's response to AAS. The importance of lab tests lies in their ability to identify potential side effects within the early stages. Early detection is essential in minimizing the risks and avoiding long-term health problems. Blood pressure tests can detect high blood pressure, a common side effect of AAS usage.

Another crucial test is the liver function test; the liver is crucial for breaking down and eliminating AAS from your body, potentially causing damage to the liver through AAS usage. The liver enzyme test measures the liver's function to ensure it's working adequately. Kidney function tests are also recommended since AAS may affect the kidneys, leading to kidney damage. The creatinine levels in the blood and urine determine how well the kidneys are functioning. Lastly, lipid profile testing measures cholesterol and triglyceride levels. AAS usage may lead to imbalanced lipid levels, putting bodybuilders at risk of heart disease. These crucial tests help detect potential risks to your health effectively. Regular monitoring through blood pressure, liver, kidney, and lipid profile tests is fundamental in minimizing potential health risks associated with AAS usage. It is advisable to prioritize regular lab tests to ensure you remain healthy even during on-cycle phases. Take care of your health, and always stay informed. Keep reading for more details.

What Bodybuilder Blood Tests are Included and Why?

Bodybuilders using testosterone and anabolic androgenic steroids (AAS) have to be smart about maximizing benefits and minimizing short and long-term side effects while exercising and eating effectively for good muscle gain, fat loss, and quality of life.  Harm reduction is critical, especially in the presence of barriers to care caused by stigma and judgment from medical practitioners. Here is a list of 14 carefully selected lab tests and panels that are essential in maintaining proper health while improving body composition and strength:

Complete Blood Count (CBC)

A complete blood count (CBC) test panel measures several components of your blood, including Red blood cells, which carry oxygen, White blood cells, which fight infection; hemoglobin, the oxygen-carrying protein in red blood cells; Hematocrit, the proportion of red blood cells to the fluid component in your blood (which correlated with blood thickness), and Platelets, which help with blood clotting.

All androgens, like testosterone and AAS, can increase red blood cells and their proportion in the blood (hematocrit), increasing blood thickness (erythrocytosis). High hematocrit can cause high blood pressure, headaches, and cardiovascular risks. This panel is essential since it determines when you reach a hematocrit of 53, indicating that blood donation or therapeutic phlebotomy is needed.

Comprehensive Metabolic Panel (CMP)

The comprehensive metabolic panel or CMP panel consists of 14 blood tests that arean initial medical screening tool to review overall health. The CMP blood test panel checks for glucose, kidney function, liver function, electrolyte, and fluid balance. FASTING IS REQUIRED.

Lipid Test Panel

This panel includes LDL (bad cholesterol), HDL (good cholesterol), and triglycerides (fatty acids dissolved in the blood).  Higher doses of T and AAS can increase LDL and decrease HDL and triglycerides. Severely decreased HDL may cause cardiovascular issues in the long term. FASTING IS REQUIRED.

Cystatin C with EGFR Kidney Test

Cystatin C is a more accurate way to determine kidney function in people with higher muscle mass since using creatinine as the primary variable can be affected by higher muscle mass, protein intake, and creatine supplementation. Another one of the measures of kidney function is the estimated glomerular filtration rate (eGFR). The glomerular filtration rate describes the flow rate of filtered fluid through the kidney. Creatinine clearance rate (CCR_Cr or CrCl) is the volume of blood plasma that is cleared of creatinine per unit of time and is a usefulmeasure for approximating the GFR. eGFR under 60 may indicate issues that are affecting kidney function.

GGT Liver Test

The GGT blood test looks for an enzyme, or protein, called gamma-glutamyl transpeptidase (GGT) in your blood. GGT is found in liver cells. This test helps your doctor look for damage to your liver or its ducts. It can also help tell the difference between liver and bone disease if your results from a different blood test called alkaline phosphatase are abnormal. Higher than-average test results could indicate liver damage from diseases such as hepatitis, cirrhosis, tumors, or pancreatic cancer. The good thing about GGT (unlike liver enzymes included in the CMP like AST and ALT) is that resistance exercise does not affect its value, so it is a more accurate way to detect liver disease in bodybuilders.

Total Testosterone by Liquid Chromatography/Mass Spectrometry, plus Free Testosterone by Equilibrium Ultrafiltration.

Men with high testosterone cannot use the regular total testosterone test based on immunoassays since it has an upper limit of 1,500 ng/dL. The LC/MS testosterone test does not have an upper limit.  Also, some labs offer calculated free testosterone instead of the equilibrium ultrafiltration-based one, which is more accurate for this critical variable.

Ultra-Sensitive Estradiol (E2) Test

The commonly used estradiol test may overestimate estradiol. That test uses immunoassay technology that cannot differentiate C-Reactive Protein (involved in inflammation) from estradiol, so it reads the combination of the two as estradiol. This ultrasensitive estradiol test is based on liquid chromatography/mass spectrometry (LC/MS), an assay technology that does not have that limitation. Furthermore, DHT analogs like oxandrolone may dramatically decrease estradiol causing joint aches and other low estradiol issues. Note: 0.4 percent of total testosterone aromatizes to estradiol.  This is the body's way of balancing testosterone's negative effect on lipids with estradiol's beneficial effect. If your total testosterone is high, so will your estradiol. Be very careful in assuming that an aromatase inhibitor is needed.  For more information, click on the effect of high and low estradiol on men's health. How to predict estradiol for different testosterone doses.

Prolactin Test

Many bodybuilders worry about increased prolactin since it has been associated with erectile dysfunction.

DHT Test

This test measures the amount of dihydrotestosterone (DHT) in the blood. Low DHT has been associated with low libido, and high DHT has been linked to acne, hair loss, and benign prostatic inflammation in a minority of men.

IGF-1 Test

Insulin-like Growth Factor 1, also known as IGF-1, is used as a biomarker for blood levels of human growth hormone. It is a hormone produced by the liver and other tissues that affects growth-promoting activities and glucose metabolism. Low IGF-1 may impede muscle growth.

Ferritin Test

Ferritin is a protein that stores iron. Red blood cells need iron to form usually and carry oxygen around your body. Low levels of ferritin lead to anemia.  TRT and anabolics make the body make more red blood cells (erythrocytosis).  This increased production decreases iron stores and ferritin.

Testosterone has been shown to decrease ferritin. Men on TRT and anabolics with high hematocrit (increased blood thickness caused by TRT/anabolics) usually donate blood or get a therapeutic phlebotomy to decrease hematocrit. There is a loss of around 30 points of ferritin during every donation.  Low ferritin can cause fatigue, restless leg syndrome, muscle aches, and other issues.

What Other Bodybuilder Blood Tests Can Be Considered?

 LH + FSH if off-cycle. 

We also provide a Post PCT Panel for people to find out if their hypothalamic-pituitary-testicular axis has recovered after a few weeks of PCT. The recovery of LH and FSH in an off-cycle period correlates to normalization of the hormone axis responsible for proper testosterone and sperm production by your body.

Other tests that may be of interest:

PSA

Althought studies published in the last 10 years do not show a link between the use of androgens with increased risk of prostate cancer, some bodybuilders may have benign prostatic enlargement (BPH) that may require PSA follow up.

Thyroid Panel

Some bodybuilders may experience fatigue issues due to pre-existing low thyroid function (hypothyroidism), so it would be a good idea for them to check their thyroid function to ensure that it is working properly for not only energy production but also effective fat loss.

Free Resources for Educated Bodybuilders:

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Suggested Reading: Testosterone Replacement Blood Test Targets

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What Does the Cardio IQ Advanced Lipid Panel Measure?

The Cardio IQ Advanced Lipid Panel includes:

• Total Cholesterol, Triglycerides, HDL, LDL and Cholesterol/HDL ratio
• LDL Particle Number (LDL-P): The number of low-density lipoprotein (LDL) particles in the blood is measured by LDL-P. Each LDL particle carries cholesterol and triglycerides to tissues all over the body. Studies have shown that a higher LDL-P count is a better indicator of heart disease risk than LDL cholesterol (LDL-C) alone. This is because a high LDL-P count means that there are more particles that cause plaque to form in the bloodstream.
• LDL Peak Size: The LDL peak size is how the size of LDL particles in the blood is spread out. Based on their size, LDL particles can be put into two main groups: small, dense LDL particles (sdLDL) and large, buoyant LDL particles. Smaller, denser LDL particles are thought to be more atherogenic because they can get deeper into arterial walls, are more likely to oxidize, and have less of a pull on LDL receptors. So, a smaller LDL peak size is linked to an increased risk of heart disease.
• LDL Pattern: The LDL pattern is the type of LDL particles that are most common in the blood, either Pattern A (large, buoyant LDL particles) or Pattern B (small, dense LDL particles) (small, dense LDL particles). Small, dense LDL particles cause atherosclerosis, which means that people with Pattern B are more likely to have heart disease.
• HDL Large: HDL large is a subclass of high-density lipoprotein (HDL) particles that are bigger. Large HDL particles are thought to protect the heart because they are better at removing cholesterol from cells (cholesterol efflux) and moving cholesterol away from cells (reverse cholesterol transport) (transporting cholesterol from peripheral tissues back to the liver for excretion). Heart disease is less likely to happen if you have a lot of large HDL particles in your blood.
• LDL Small: LDL small means small, dense LDL particles, which are more likely to cause atherosclerosis than large, buoyant LDL particles. High levels of small LDL particles are linked to a higher risk of cardiovascular disease because they can get into arterial walls more easily and cause plaque to form.
• LDL Medium: The LDL particles that are in between the small, dense LDL and the big, floaty LDL are called LDL medium. When compared to the other two subclasses, these particles have a middle level of atherogenic potential. Less is known about the clinical importance of medium-sized LDL particles, but it is important to think about them as a part of the whole LDL particle profile.
• Apolipoprotein B (ApoB): ApoB is the main protein in all atherogenic lipoproteins, like LDL, VLDL, and IDL (IDL). One ApoB molecule is in each atherogenic particle. By measuring ApoB levels, you can get an idea of how many atherogenic particles are in your blood. Heart disease is more likely to happen if you have a high level of ApoB.
• Lipoprotein (a) (Lp(a)) is a lipoprotein that has the same structure as LDL, but Apo(a) is attached to ApoB instead of ApoB alone. Lp(a) makes atherosclerosis worse by making plaques and slowing down fibrinolysis (the breakdown of blood clots). High Lp(a) levels are a risk factor for cardiovascular disease on their own, and this risk is mostly caused by genes.

By looking at these lipid markers, doctors can get a better idea of a patient's risk for cardiovascular disease and make treatment plans that focus on specific lipid abnormalities. This all-around approach could help lower the overall risk of getting heart disease.

How Long Does it Take to Get Cardio IQ Panel Results?

Results for this test take 2 weeks to receive.

How to Prepare for the Cardio IQ Test

It is recommended to fast for 12-14 hours before getting your blood drawn for this test.

Why is Cardio IQ Advanced Lipid Panel More Useful than a Simple Lipid Panel?

The Cardio IQ® Report provides an in-depth assessment of cardiovascular risks to help physicians recommend the ideal individualized treatment option for patient to minimize cardiovascular disease.

The report is simple, yet comprehensive. It is color-coded to display progressive risk values versus goal using “optimal,” “moderate,” and “high-risk” categories and grouped by functional categories.

This advanced test uses a technology called Ion mobility. This test goes far beyond your basic lipid test, for starters this test helps to reclassify a patient’s cardiovascular risk. Nearly half of all heart attack patients were found to have no prior risk which would indicate they were heading toward an attack. Cardio IQ Ion Mobility tests directly detects, measures and quantifies the number and size of all lipoprotein subfractions.  Knowing what particles make up your LDL and HDL cholesterol may be important. Ion Mobility Technology provides subclass separation that will allow your healthcare provider to identify your cardiovascular risk over time. Following the change in your lipid profile as you respond to diet, exercise and possible medication to reduce your cardiovascular risk is important. Ion Mobility provides the opportunity to determine if treatment is working and if not, optimize the aggressiveness of therapy to hopefully make a difference that can be seen in the Ion Mobility measurement and graphical representation of your LDL and HDL particles.

Ion mobility technology precisely quantifies lipoprotein fractions across the entire lipoprotein spectrum; this comprises very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) particles. Ion mobility identifies 2 main subclasses of HDL: large HDL and small HDL. The antioxidant properties of large HDL may help protect the arterial wall. A decreased large HDL subclass has historically suggested increased CVD risk.

An elevated total LDL particle number is associated with a 1.2 to 1.4-fold increase in cardiovascular disease risk. Similarly, elevated small and medium LDL particle numbers have been associated with a 1.2 to 1.4-fold increase.

What to Do to Improve Cardio IQ Advanced Lipid Panel Abnormal Results?

The following table shows what to do when any of the lab test results shown by your Cardio IQ test is abnormal.

DiscountedLabs.com offers affordable blood tests you can order online in the United Sates without the need of a doctor's order. We have no hidden fees and have an easy ordering process.

HOW DOES DISCOUNTEDLABS.COM WORK?

1. Go to the "Find a Location" page to find the closest lab location. No need to make an appointment since walk-ins are welcomed. Once you have identified your closest location, go to step 2.

2. Go to "Choose a Test" and add your selection (s) in the shopping cart. If you prefer to save money on bundled tests, we have created "Lab Test Panels" that can help you decide what to order.

3. If you have a discount coupon code, add it to your cart.

4. A $8 lab processing fee will be added to your total.

5. Pay using a credit card.

6. You will receive an order confirmation and instructions email on how to download your lab request.

7. Print lab request form that you downloaded.

8. Take that form to the closest lab location with a picture ID. Get your blood drawn.

9. You will receive an email when the results are ready for you to download.

   Note: You cannot place an order under someone else's profile. The profile person's name will appear on the lab order form.

    

   If you have further questions, please email [email protected].

What is the Cardio IQ® Insulin Resistance Panel with Score ?

In people with insulin resistance (IR), their cells don't respond well to insulin and don't absorb enough glucose from the blood. This can lead to conditions like prediabetes and type 2 diabetes, along with others like high blood pressure, heart disease, stroke, non-alcoholic fatty liver disease, polycystic ovary syndrome (PCOS), and certain types of cancer. Spotting and addressing insulin resistance early can help prevent or slow down these health issues.

Insulin resistance can start slowly and be hard to identify. In the early stages, the pancreas may produce extra insulin to make up for the reduced sensitivity. This can keep blood sugar and HbA1c (a measure of long-term blood sugar control) at normal levels. Monitoring only blood sugar won't catch the start of insulin resistance. If insulin sensitivity keeps dropping, the extra insulin produced won't be able to keep blood sugar levels normal, leading to higher blood sugar levels, prediabetes, and eventually type 2 diabetes.

There are research methods to detect insulin resistance even in people with normal fasting glucose levels, but they are time-consuming and complicated, so they're not practical for routine use. Simpler methods have shown promise for assessing the risk of diabetes. For instance, combining HbA1c and the HOMA-IR score, which uses fasting insulin and glucose levels, improved risk assessment for type 2 diabetes compared to using HbA1c alone.

C-peptide, a molecule released with insulin, can be an indirect marker of insulin resistance. Compared to insulin, C-peptide lasts longer in the blood, is present at higher levels, and fluctuates less. But measuring C-peptide is not commonly done due to the cost and inconvenience of collecting more samples and doing an additional test.

The Cardio IQ® Insulin Resistance Score uses fasting insulin and C-peptide measurements to estimate a person's likelihood of having insulin resistance. It eliminates the need for multiple samples and reduces the chance of errors that can occur with some other tests.

This score was developed in a study and used to estimate the odds of having insulin resistance. It showed that having a high score (indicating a greater probability of insulin resistance) was linked to an increased risk of developing type 2 diabetes in a group of older Europeans, even after accounting for other risk factors.

Fasting Required for 10-12 hours. Water only.

Interpretive information

Individuals with elevated fasting insulin and/or C-peptide levels may have IR, which is reflected in the IR score.

An IR score of <33 suggests that an individual has normal insulin sensitivity.
A score of 33 to 66 suggests that an individual has >4-fold greater odds of having IR compared with an individual with a score <33 .
A score >66 suggests that an individual has >15-fold greater odds of having IR compared to an individual with a score

Frequently Asked Questions

Question 1. What is insulin resistance (IR)? Why does it matter?

References

1. Reaven GM. The insulin resistance syndrome. Curr Atheroscler Rep. 2003;5(5):364-371. doi:10.1007/s11883-003-0007-0
2. Saisho Y. β-cell dysfunction: its critical role in prevention and management of type 2 diabetes. World J Diabetes. 2015;6(1):109-124. doi:10.4239/wjd.v6.i1.109
3. Abbasi F, Shiffman D, Tong CH, et al. Insulin resistance probability scores for apparently healthy individuals. J Endocr Soc. 2018;2(9):1050-1057. doi:10.1210/js.2018-00107
4. Leighton E, Sainsbury CA, Jones GC. A practical review of C-peptide testing in diabetes. Diabetes Ther. 2017;8(3):475-487. doi:10.1007/s13300-017-0265-4
5. Pei D, Jones CN, Bhargava R, et al. Evaluation of octreotide to assess insulin-mediated glucose disposal by the insulin suppression test. Diabetologica. 1994;37(8):843-845. doi:10.1007/BF00404344
6. DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237(3):E214-223. doi:10.1152/ajpendo.1979.237.3.E214
7. Taylor SW, Clarke NJ, Chen Z, et al. A high-throughput mass spectrometry assay to simultaneously measure intact insulin and C-peptide. Clin Chim Acta. 2016;455:202-208. doi:10.1016/j.cca.2016.01.019
8. Bril F, McPhaul MJ, Kalavalapalli S, et al. Intact fasting insulin identifies nonalcoholic fatty liver disease in patients without diabetes. J Clin Endocrinol Metab. 2021;106(11):e4360-e4371. doi:10.1210/clinem/dgab417
9. De Cosmo S, Menzaghi C, Prudente S, et al. Role of insulin resistance in kidney dysfunction: insights into the mechanism and epidemiological evidence. Nephrol Dial Transplant. 2013;28(1):29-36. doi:10.1093/ndt/gfs290.

This panel includes CBC (Complete Blood Count) with differential, CMP (Comprehensive Metabolic Panel), and Lipid Panel (LDL, HDL, Triglycerides). There are a total of 30 tests included!

The CBC with Differential Panel Includes

Blood red cell measurements:

RBC, red blood cells known as erythrocytes, transport oxygen from your lungs to your body's tissues and organs.

The total amount of RBCs in your blood sample is known as the RBC count. Several fundamental RBC measures are made during a CBC test:

The total amount of RBCs in your blood sample is known as the RBC count.

The amount of this oxygen-carrying protein contained inside RBCs is quantified by hemoglobin.

The amount of RBCs in your blood as a percentage of total blood volume is measured by hematocrit.

A CBC also offers information on the RBC's external characteristics. These are referred to as RBC indices, and there are various types of them:

The average size of RBC is determined by a technique called mean corpuscular volume (MCV).

The average quantity of hemoglobin inside each RBC is known as mean corpuscular hemoglobin (MCH).

A determined indicator of how concentrated hemoglobin is within RBCs is the mean corpuscular hemoglobin concentration (MCHC).

Red cell distribution width (RDW) measures how much your RBCs' sizes vary.

Reticulocyte count, or the total number of freshly released young RBCs in your blood sample, may be included in the CBC. Another way to measure it is as a percentage.

White Blood Cell Measurements

WBCs, also known as leukocytes, are a crucial component of the body's immune system.

The total number of WBCs in a blood sample is measured by the WBC count, which is part of a typical CBC.

The CBC with differential is one of the most popular CBC variations. The five different types of WBCs are broken down into the WBC differential as follows:

Most white blood cells (WBCs) are composed of neutrophils made by the bone marrow to combat a wide range of inflammatory and infectious disorders.

B-cells and T-cells, two types of lymphocytes fighting bacteria and other blood pathogens, are mainly located in the lymphatic system.

Monocytes: Monocytes eliminate damaged or dead cells while collaborating with neutrophils to fight infections and other disorders.

Eosinophils: Eosinophils are WBCs that become activated in response to some illnesses and allergies.

Basophils: Basophils play a role in wound healing, allergic reactions, and the early detection of infections.

A CBC with differential may be performed as part of basic blood testing, or it may be done if the original standard CBC is abnormal. The CBC with differential can be used to spot aberrant amounts of particular WBCs since each kind of WBC has a different purpose and can provide information about underlying health issues.

Platelet Measurements

Blood-circulating cell fragments known as platelets (PLT), also known as thrombocytes, are crucial for blood coagulation. PLT aid in stopping bleeding when an injury occurs by adhering to the injury site and clumping together to create a temporary stopper.

The PLT count, or the quantity of PLT in your blood sample, is a regular part of the CBC.

Your doctor may occasionally request that the lab measure the mean PLT volume (MPV), which establishes the typical size of PLT.

The Comp Metabolic Panel or CMP panel 

This panel consists of 14 blood tests, an initial medical screening tool to review overall health. The CMP blood test panel checks for kidney function, liver function, and electrolyte and fluid balance. FASTING IS REQUIRED. These are the tests included:

1.     Sodium (Na)

Sodium is one of the body's principal minerals, regulated by the kidneys. It plays a vital role in water balance in your body. A low sodium level may be caused by diarrhea, vomiting, or excessive sweating. A high level can be caused by dehydration, excessive salt intake in your diet, or certain diseases. Numerous drugs, including diuretics, certain blood pressure medications, and steroids, may alter the sodium level.

2.     Potassium (K)

Potassium is one of the body's principal minerals, primarily inside cells. It helps maintain water balance and proper function of nerves and muscles. Low or high levels in the blood are of critical significance and should be evaluated by your healthcare provider. This is especially important if you are taking a diuretic or heart medication. A high level may indicate kidney or liver disease, too much medication, or bodily injury, such as a burn. A low potassium level can develop rapidly, most frequently produced as a side effect of drugs that cause increased urination.

3.    Chloride (C)

Chloride is one of the body's minerals involved with water balance. Most body chloride comes from salt in the diet. A high chloride level may mean severe dehydration, certain kidney disorders, or hyperventilation. A low chloride level may result from excessive vomiting, diarrhea, severe burns, excessive sweating, or kidney failure. Borderline low or high levels of chloride have very little significance.

4.     Carbon Dioxide (CO2)

n the body, most of the carbon dioxide (CO2) is in the form of a substance called bicarbonate (HCO3). Therefore, the CO2 blood test measures your blood bicarbonate level. Changes in your CO2 level may suggest that you lose or retain fluid, which causes an imbalance in your body's electrolytes. CO2 levels in the blood are influenced by kidney and lung function. The kidneys are mainly responsible for maintaining normal bicarbonate levels. The CO2 level is interpreted with other results to aid in medical diagnoses.

5.     Albumin (Alb)

Albumin is the most significant portion of total blood protein. Modest decreases in albumin may be seen in people with low thyroid gland function and protein-losing conditions. Decreased blood albumin may indicate many disorders, including poor nutrition and advanced liver disease.

6.     Alkaline Phosphatase (ALP)

Alkaline phosphatase is an enzyme found primarily in bone and the liver. It is commonly increased when the bile duct is blocked, which may be caused by gallstones. Elevated levels may indicate the presence of bone or liver disorders.

7.     Bilirubin (Bil) Total

Bilirubin is the primary pigment in bile and a significant product of normal red cell breakdown. It helps evaluate liver function and various anemias and in evaluating jaundice and yellowing of the skin.

8.     Aspartate Transaminase (AST)

Aspartate aminotransferase (AST) is an enzyme in the liver and cardiac and skeletal muscle. AST may rise in liver, heart, and muscle disorders. It can also increase following strenuous, prolonged exercise.

9.   Transaminase (ALT)

Alanine aminotransferase (ALT) is an enzyme produced primarily in the liver, skeletal, and heart muscles.ALT rises in the instance of liver disease. ALT is present in the liver in a higher concentration than AST and is more specific for differentiating liver injury from muscle damage.

10.  Blood Urea Nitrogen (BUN)

Urea, measured as blood urea nitrogen (BUN), is a waste product derived from the natural breakdown of protein in the liver. Urea is excreted in the urine after blood is filtered through the kidneys. The urea nitrogen level reflects protein metabolism and the kidneys' effectiveness in purifying blood.

The BUN/creatinine ratio is calculated by dividing the urea nitrogen result by the creatinine result. This ratio can help determine whether elevated urea nitrogen is due to impaired kidney function or other factors such as dehydration, urinary blockage, or excessive blood loss.

If BUN and Creatinine results are within the normal reference range, the BUN/Creatinine ratio will not be reported (not applicable). Clinical Significance: The BUN/Creatinine ratio is helpful in the differential diagnosis of acute or chronic renal disease.

11.  Total Protein

Urea, measured as blood urea nitrogen (BUN), is a waste product derived from the natural breakdown of protein in the liver. Urea is excreted in the urine after blood is filtered through the kidneys. The urea nitrogen level reflects protein metabolism and the kidneys' effectiveness in purifying blood.

12.  Calcium (Ca)

Calcium is one of the most critical elements in the body. It is essential for maintaining and repairing bone and teeth, heart function, muscle function, and blood clotting. Ninety-nine percent of the calcium in your body is contained in your bones, and only one percent is in the blood. Although most of the calcium in the body is in the bones, the body regulates blood calcium levels very tightly since its functions are essential to health and performance.

13.  Creatinine (Cr) with calculated eGFR

Creatinine is derived from muscles and released into the blood. It is removed from the body by the kidneys. When the creatinine level is elevated, a decrease in kidney function is suggested. For patients 50 years of age and older who identify as African-American, the upper reference range for creatinine is approximately 10-15% higher.

Estimated Glomerular Filtration Rate (eGFR) is a test for kidney damage. eGFR is calculated using your serum creatinine result, age, and gender. Creatinine is not sensitive to early renal impairment since it varies with age, gender, and ethnic background. If you are African American, your eGFR is estimated differently. Since race is not reported in this screening, you will need to use the written result associated with your race. To get an African American-specific result, you can multiply this result by 1.21 to get your true eGFR. The same reference ranges will apply.

14.  Glucose

Glucose (“blood sugar”) is the chief energy source for all cells in the body. Glucose levels are regulated by hormones produced by your pancreas, including insulin. A glucose level outside the optimal range could signify that the body is not correctly creating or using insulin. These conditions are hypoglycemia (low blood sugar), prediabetes (elevated blood sugar), and diabetes (high blood sugar). For the most accurate result, you should fast (not eat or drink anything but water) for at least 8 hours before your screening. If you were not fasting at the time of your screening, you should interpret your result against an optimal range of less than 140 mg/dL.

When the doctor looks at your report of the CMP blood test panel, he organizes it in his mind according to body systems or possible diseases. The sodium, potassium, chloride, and total carbon dioxide measure the salt and acid-base balance of the body. The glucose level is how we diagnose diabetes. The BUN, Creatinine, and BUN to Creatinine ratio tell us how the kidneys function and can give us an idea about water balance and possible heart function. The calcium and phosphorus provide information on a possible endocrine disorder called hyperparathyroidism and can give information on possible bone disease and malabsorption. The total protein, albumin, and globulin can point to a liver problem, a kidney problem, or an immune disorder. The total direct bilirubin can be abnormal in liver disease and some blood diseases. The alkaline phosphatase, AST, and ALT can be irregular in liver disease.

The Lipids Panel:

Evaluates the risk for developing atherosclerosis (arterial plaque) and coronary heart disease. This test includes: Total Cholesterol, Triglycerides, HDL Cholesterol, LDL Cholesterol, Total Cholesterol/HDL Ratio

This test requires fasting for 8 hours.

There are typically no symptoms or indicators of high cholesterol.

Examining your cholesterol is the only way to determine if you have high cholesterol. Your medical team can measure your cholesterol levels using a quick blood test known as a "lipid profile."

How Does a Cholesterol Test Work?

A quick blood sample is necessary for the cholesterol screening test. Before your cholesterol test, you might need to fast (without food or liquids) for eight to twelve hours. Ask your doctor for advice on how to get ready for the examination.

The Lipid Profile Panel Measures the Following Tests:

• LDL, also known as "bad" cholesterol, is a low-density lipoprotein. High LDL cholesterol levels can cause plaque to build up in your arteries, which can cause heart disease or stroke.

• HDL, also referred to as "good" cholesterol. Because high levels of HDL can reduce your risk of heart disease and stroke, it is referred to as "good" cholesterol.

• Triglycerides are a form of blood fat that your body uses as fuel. Your heart attack and stroke risk can increase if you have high triglyceride levels and low HDL or high LDL cholesterol. After eating, the energy that is not needed immediately is converted into triglycerides and transported to fat cells for storage. A normal triglyceride level is about 45-150 mg/dL. Elevated levels (hypertriglyceridemia) are associated with an increased risk of cardiovascular disease, especially when accompanied by high cholesterol levels. Extremely high triglyceride levels (greater than 1,000 mg/dL) can cause pancreatitis. Triglycerides should be measured after fasting for at least eight hours.

• Total cholesterol, the sum of your blood's HDL, LDL, and triglyceride levels, is the level of cholesterol.  It is a fatty substance that circulates in the blood; cholesterol is essential to cell membranes, certain hormones, vitamin D, and bile acids. A healthy total cholesterol level is 120-200 mg/dL. Elevated total cholesterol (hypercholesterolemia) is known to increase the risk of cardiovascular disease, but it is more helpful to look at specific types of cholesterol. Low-density lipoproteins (LDL) -- so-called "bad" cholesterol -- can deposit cholesterol in artery walls, causing atherosclerosis (hardening of the arteries). But high-density lipoproteins (HDL) -- so-called "good" cholesterol -- help clear cholesterol from the body and may reduce the risk of cardiovascular disease. The National Cholesterol Education Program recommends that people try to achieve a total cholesterol level below 200 mg/dL, an LDL level below 100 mg/dL, and an HDL level of at least 40 mg/dL.

This CBC with Differential Panel Includes

Tests included:

• White blood cell count (WBC or leukocyte count)
• WBC differential count
• Red blood cell count (RBC or erythrocyte count)
• Hematocrit (Hct)
• Hemoglobin (Hbg)
• Mean corpuscular volume (MCV)
• Mean corpuscular hemoglobin (MCH)
• Mean corpuscular hemoglobin concentration (MCHC)
• Red cell distribution width (RDW)
• Platelet count
• Mean Platelet Volume (MPV)

Complete Blood Count

 Whole blood is made up of various types of cells suspended in a liquid called plasma. The complete blood count (CBC) is an inventory of the different cellular components of the blood: red blood cells, white blood cells, and platelets. Blood cell counts are typically reported as the number of cells in a cubic millimeter of blood (cells/mm3) or as a percentage of all blood cells.

 Red Blood Cells

 Red blood cells (erythrocytes) carry oxygen from the lungs to the body's cells, bound to a molecule called hemoglobin. A reduction in red blood cells characterizes anemia, often leaving a person tired, weak, and short of breath. Several tests are used to help diagnose various types of anemia.

 Red Blood Cell Count (RBC):

The total number of red blood cells in a quantity of blood. Normal ranges are 4.5-6.0 million cells/mm3 for men and 4.0-5.5 million cells/mm3 for women. (Women typically have lower counts than men due to blood loss through menstruation.)

 Hematocrit (HCT):

This screening measures how much of your blood is made of red blood cells (RBCs)—the proportion of red blood cells as a percentage of total blood volume. Normal hematocrit is 40-55% for men and 35-45% for women. A hematocrit measurement helps identify anemia, the presence of liver disease, bleeding disorders, and red cell production within the circulatory system. Hematocrit increases with altitude adaptation or dehydration. Women generally have lower hematocrit values than men. Some men on testosterone therapy have high hematocrit that can be managed if monitored.

 Hemoglobin (HGB):

The number of grams of hemoglobin in a deciliter of blood (g/dL). Average levels in healthy adults are 14-18 g/dL for men and 12-16 g/dL for women. As a rough guideline, hemoglobin should be about one-third of the hematocrit. Hemoglobin is an iron-containing protein found in red blood cells (RBCs), enabling the cells to carry oxygen and carbon dioxide in the blood. Measuring hemoglobin gives a picture of the ability of the blood to carry oxygen to every cell of your body. A low hemoglobin level may indicate anemia. Hemoglobin increases with altitude adaptation. In general, women have lower hemoglobin values than men.

 Mean Corpuscular Hemoglobin (MCH) and MCH Concentration (MCHC):

The amount or concentration of hemoglobin in an average red blood cell. Mean corpuscular hemoglobin (MCH) calculates the oxygen-carrying hemoglobin inside your red blood cells (RBCs). A high MCH indicates an increased level of hemoglobin, the oxygen-carrying protein, in your RBCs. Increases can be associated with anemia. Often, increased MCH occurs in conjunction with a high mean corpuscular volume—or large red blood cells-which suggest macrocytic anemia. A low MCH indicates that you have a decreased level of oxygen-carrying protein in your red blood cells. Decreases can be associated with certain types of anemia. Often, decreases occur in conjunction with low mean corpuscular volume—or small RBCs—which suggest microcytic anemia. Hypochromic anemia, resulting from hemoglobin deficiency, can also be a possibility.

Mean corpuscular hemoglobin concentration (MCHC) calculates the percentage of oxygen-carrying hemoglobin in the individual red blood cells (RBCs). A high MCHC indicates an increased level of hemoglobin in your RBCs. Increased MCHC is usually a technical rather than a medical issue. A high level may be caused by distortions in the shape of your RBCs caused by problems in the collection, transport, or storage of the blood sample. A low MCHC indicates a decreased level of hemoglobin in your RBCs. Decreases can be associated with certain types of anemia, such as iron deficiency or the hereditary disease thalassemia.

 Mean Corpuscular Volume (MCV):

The average size, or volume, of individual red blood cells. Mean corpuscular volume (MCV) measures the average size of your red blood cells (RBCs). A high MCV indicates large or macrocytic RBCs. A high MCV is associated with specific varieties of anemia and can tell a deficiency in vitamin B12 or folic acid. A low MCV indicates small, or microcytic, red blood cells. A low MCV is associated with anemia and can indicate an iron deficiency, chronic illness, or the hereditary disease, thalassemia. Iron deficiency can lead to smaller than normal red blood cells, while certain vitamin deficiencies and some drugs can produce more extensive than normal cells.

 Red Blood Cell Distribution Width (RDW):

A measure of the size and uniformity of red blood cells.

 White Blood Cells

White blood cells (WBCs) are the body's protectors. Each of the five varieties of WBCs plays a specific role in defending your body against illness or injury.

White blood cells (leukocytes) carry out the body's immune responses. The CBC looks at the numbers of various types of white blood cells.

 White Blood Cell Count (WBC):

The total number of white blood cells in a quantity of blood. A healthy adult typically has 4,000-11,000 white blood cells/mm3. A WBC increase often indicates that a person is actively fighting an infection or has recently received a vaccine. Decreased WBC (leukopenia) can leave a person vulnerable to various pathogens and cancers.

 Differential: a report of the proportions of different types of white blood cells as a percentage of the total number of white cells; these percentages may be multiplied by the WBC to obtain absolute counts.

 Neutrophils:

A type of cell that fights bacterial infections. Neutrophilic granulocytes (“neutrophils”) are the most abundant white blood cell. Neutrophils usually make up 50-70% of all white blood cells. The risk of bacterial infection increases when the absolute neutrophil count falls below about 500-750 cells/mm3. Neutrophils are an essential component of the immune system. They respond to bacterial infections and other types of inflammation. In a condition, neutrophils seep out of the blood vessels in response to factors released as sites of infection. The predominant cells in pus that we observe in a wound are neutrophils.

 Lymphocytes:

There are two main types of lymphocytes. B cells produce antibodies that fight foreign invaders in the body, while T cells target infected or cancerous cells and help coordinate the overall immune response. An average lymphocyte count is 20-40% of all white blood cells. Lymphocytes are the second most common white blood cell (WBC). Lymphocytes are divided into larger cells, natural killer lymphocytes, and smaller cells, B and T lymphocytes. Natural killer cells are essential in our immune system to defend against tumors and viral infections. They respond to alterations in the surface of tumor cells and infected cells. B and T lymphocytes adapt to infected cells by either a cellular response mediated by T lymphocytes or antibodies mediated by B lymphocytes.

 Monocytes:

A type of cell that fights pathogens by engulfing and destroying them. Monocytes circulate in the blood for about 24 hours; when they leave the bloodstream and migrate into the tissues, they mature into macrophages. Monocytes and macrophages typically account for 2-10% of all white blood cells. Like the other white blood cells (WBCs), monocytes originate in the bone marrow, the complex spaces within many of our larger bones. Monocyteseat foreign intruders (phagocytosis) and kill infected cells. Monocytes are essential in triggering atherosclerosis that affects our arteries and can lead to heart disease and stroke.

 Eosinophils:

Cells that play a role in defense against parasites and allergic reactions. Eosinophilic granulocytes (“eosinophils”) are part of our immune system’s response to infection, including from parasites. They usually make up 0-6% of all white blood cells. Eosinophils, basophils, and mast cells are essential in allergic reactions and asthma.

 Basophils:

Another type of cell involved in allergic reactions is the release of histamine. They usually account for 1% or less of all white blood cells. Basophilic granulocytes (“basophils”) - are the least common of the five white blood cell types. When activated, basophils secrete or release many compounds, including histamine and interleukin-4. Both compounds are essential in the allergic response.

 Platelets

 Platelets (thrombocytes) are necessary for blood clotting. Averages are the smallest type of cell found in the blood. A normal platelet count is about 130,000-440,000 cells/mm3. Low platelet counts (thrombocytopenia) -- which can lead to easy bruising and excessive bleeding -- may be caused by certain drugs, autoimmune reactions, accelerated destruction by the spleen, or certain immune diseases. Platelets help stop bleeding after an injury by gathering around the injury site, plugging the hole in the bleeding vessel, and helping the blood clot more quickly. Platelet counts may be done if you are prone to bruising or about to have surgery. The platelet count may change with bleeding disorders, heart disease, diabetes, and inflammatory conditions.

MPV

Stands for Mean Platelet Volume. Platelet volume varies with the age of the platelets. Newer platelets are significantly larger than older ones.

The comprehensive metabolic panel (CMP) is a blood test that measures several substances in your blood, including electrolytes, proteins, glucose, and liver and kidney function markers. It is often used to help diagnose and monitor a variety of medical conditions, such as diabetes, kidney disease, and liver disease. The test is usually done as part of a routine health evaluation or to check for potential health problems. The results of the CMP are usually reported as a series of numbers, with a reference range indicating the normal values for each substance measured. It is important to note that the interpretation of a comp metabolic panel may vary depending on the individual's medical history and other factors. A healthcare provider should be consulted to interpret the test results correctly. Tests included:

• Glucose
• Sodium
• Potassium
• Chloride
• Carbon Dioxide
•  Calcium
•  Protein
• Albumin
• Alanine transaminase (ALT)
• Aspartate transaminase (AST)
• Bilirubin
• Alkaline phosphatase (ALP)
• Blood urea nitrogen (BUN)
•  Creatinine
• eGFR

The comp metabolic panel or CMP panel consists of 14 blood tests that are an initial medical screening tool to review overall health. The CMP blood test panel checks for kidney function, liver function, and electrolyte and fluid balance. FASTING IS REQUIRED. These are the tests included:

1.     Sodium (Na)

Sodium is one of the body's principal minerals, regulated by the kidneys. It plays a vital role in water balance in your body. A low sodium level may be caused by diarrhea, vomiting, or excessive sweating. A high level can be caused by dehydration, excessive salt intake in your diet, or certain diseases. Numerous drugs, including diuretics, certain blood pressure medications, and steroids, may alter the sodium level.

2.     Potassium (K)

Potassium is one of the body's principal minerals, primarily inside cells. It helps maintain water balance and proper function of nerves and muscles. Low or high levels in the blood are of critical significance and should be evaluated by your healthcare provider. This is especially important if you are taking a diuretic or heart medication. A high level may indicate kidney or liver disease, too much medication, or bodily injury, such as a burn. A low potassium level can develop rapidly, most frequently produced as a side effect of drugs that cause increased urination.

3.     Chloride (C)

Chloride is one of the body's minerals involved with water balance. Most body chloride comes from salt in the diet. A high chloride level may mean severe dehydration, certain kidney disorders, or hyperventilation. A low chloride level may result from excessive vomiting, diarrhea, severe burns, excessive sweating, or kidney failure. Borderline low or high levels of chloride have very little significance.

4.     Carbon Dioxide (CO2)

n the body, most of the carbon dioxide (CO2) is in the form of a substance called bicarbonate (HCO3). Therefore, the CO2 blood test measures your blood bicarbonate level. Changes in your CO2 level may suggest that you lose or retain fluid, which causes an imbalance in your body's electrolytes. CO2 levels in the blood are influenced by kidney and lung function. The kidneys are mainly responsible for maintaining normal bicarbonate levels. The CO2 level is interpreted with other results to aid in medical diagnoses.

5.     Albumin (Alb)

Albumin is the most significant portion of total blood protein. Modest decreases in albumin may be seen in people with low thyroid gland function and protein-losing conditions. Decreased blood albumin may indicate many disorders, including poor nutrition and advanced liver disease.

6.     Alkaline Phosphatase (ALP)

Alkaline phosphatase is an enzyme found primarily in bone and the liver. It is commonly increased when the bile duct is blocked, which may be caused by gallstones. Elevated levels may indicate the presence of bone or liver disorders.

7.     Bilirubin (Bil) Total

Bilirubin is the primary pigment in bile and a significant product of normal red cell breakdown. It helps evaluate liver function and various anemias and in evaluating jaundice and yellowing of the skin.

8.     Aspartate Transaminase (AST)

Aspartate aminotransferase (AST) is an enzyme in the liver and cardiac and skeletal muscle. AST may rise in liver, heart, and muscle disorders. It can also increase following strenuous, prolonged exercise.

9.   Transaminase (ALT)

Alanine aminotransferase (ALT) is an enzyme produced primarily in the liver, skeletal, and heart muscles.ALT rises in the instance of liver disease. ALT is present in the liver in a higher concentration than AST and is more specific for differentiating liver injury from muscle damage.

10.  Blood Urea Nitrogen (BUN)

Urea, measured as blood urea nitrogen (BUN), is a waste product derived from the natural breakdown of protein in the liver. Urea is excreted in the urine after blood is filtered through the kidneys. The urea nitrogen level reflects protein metabolism and the kidneys' effectiveness in purifying blood.

The BUN/creatinine ratio is calculated by dividing the urea nitrogen result by the creatinine result. This ratio can help determine whether elevated urea nitrogen is due to impaired kidney function or other factors such as dehydration, urinary blockage, or excessive blood loss.

Just so you know, if BUN and Creatinine results are within the normal reference range, the BUN/Creatinine ratio will not be reported (not applicable). Clinical Significance: The BUN/Creatinine ratio is helpful in the differential diagnosis of acute or chronic renal disease.

11.  Total Protein

Urea, measured as blood urea nitrogen (BUN), is a waste product derived from the natural breakdown of protein in the liver. Urea is excreted in the urine after blood is filtered through the kidneys. The urea nitrogen level reflects protein metabolism and the kidneys' effectiveness in purifying blood.

12.  Calcium (Ca)

Calcium is one of the most critical elements in the body. It is essential for maintaining and repairing bone and teeth, heart function, muscle function, and blood clotting. Ninety-nine percent of the calcium in your body is contained in your bones, and only one percent is in the blood. Although most of the calcium in the body is in the bones, the body regulates blood calcium levels very tightly since its functions are essential to health and performance.

13.  Creatinine (Cr) with calculated eGFR

Creatinine is derived from muscles and released into the blood. It is removed from the body by the kidneys. When the creatinine level is elevated, a decrease in kidney function is suggested. For patients 50 years of age and older who identify as African-American, the upper reference range for creatinine is approximately 10-15% higher.

Estimated Glomerular Filtration Rate (eGFR) is a test for kidney damage. eGFR is calculated using your serum creatinine result, age, and gender. Creatinine is not sensitive to early renal impairment since it varies with age, gender, and ethnic background. If you are African American, your eGFR is estimated differently. Since race is not reported in this screening, you will need to use the written result associated with your race. To get an African American-specific result, you can multiply this result by 1.21 to get your true eGFR. The same reference ranges will apply.

14.  Glucose

Glucose (“blood sugar”) is the chief energy source for all cells in the body. Glucose levels are regulated by hormones produced by your pancreas, including insulin. A glucose level outside the optimal range could signify that the body is not correctly creating or using insulin. These conditions are hypoglycemia (low blood sugar), prediabetes (elevated blood sugar), and diabetes (high blood sugar). For the most accurate result, you should fast (not eat or drink anything but water) for at least 8 hours before your screening. If you were not fasting at the time of your screening, you should interpret your result against an optimal range of less than 140 mg/dL.

When the doctor looks at your report of the CMP blood test panel, he organizes it in his mind according to body systems or possible diseases. The sodium, potassium, chloride, and total carbon dioxide measure the salt and acid-base balance of the body. The glucose level is how we diagnose diabetes. The BUN, Creatinine, and BUN to Creatinine ratio tell us how the kidneys function and can give us an idea about water balance and possible heart function. The calcium and phosphorus provide information on a possible endocrine disorder called hyperparathyroidism and can give information on possible bone disease and malabsorption. The total protein, albumin, and globulin can point to a liver problem, a kidney problem, or an immune disorder. The total direct bilirubin can be abnormal in liver disease and some blood diseases. The alkaline phosphatase, AST, and ALT can be irregular in liver disease.

What Tests Are Included in a Complete Metabolic Profile (CMP)?

Now let's go over the CMP blood tests in somewhat more detail.

The Serum Glucose test is how we diagnose diabetes. If the glucose is 126 on a fasting blood draw, meaning the blood was drawn first thing in the morning after an overnight fast, before you ate any breakfast, then you have diabetes. Now, that's assuming that when we repeat the test, we get the same results. It needs to be abnormal more than once.

The Uric Acid test is how we diagnose gout.

The BUN, Blood Urea Nitrogen, can be abnormal in kidney disease, dehydration, heart failure, malnutrition, and liver disease.

Serum Creatinine is a measure of kidney function. The BUN to Creatinine ratio can give information on the possible cause of kidney dysfunction, say heart failure or dehydration, or decreased kidney blood flow.

Serum Sodium can be increased in dehydration. Serum Sodium can be decreased in diuretic therapy, and the syndrome of inappropriate antidiuretic hormone is abbreviated SIADH. Serum Potassium can be grown in adrenal insufficiency and acute renal failure, as well as with an improper combination of medicines. Potassium could be decreased in primary aldosteronism, diuretic therapy, and renal tubular acidosis.

Serum Chloride can be increased in dehydration and renal tubular acidosis, and it can be decreased in congestive heart failure and primary aldosteronism. Carbon Dioxide can be increased in primary pulmonary diseases, such as severe COPD and primary aldosteronism. It can be decreased in metabolic acidoses, such as diabetic ketoacidosis.

Serum Calcium can be increased in an endocrine disease called primary hyperthyroidism. It can also be an increase in malignancy. However, most of the time, when a person has a high Serum Calcium found unexpectedly, it's simply due to hyperparathyroidism, which can be treated. We can also have a decreased Serum Calcium in hypoparathyroidism and vitamin D deficiency.

The Serum Phosphorus can be increased in acute or chronic renal failure and decreased in malabsorption and vitamin D deficiency.

The total Serum Protein can be increased in multiple myeloma and sarcoidosis, and it can be decreased in chronic glomerulonephritis, a type of chronic renal disease.

Serum Albumin can be decreased in liver disease, cirrhosis, and nephrotic syndrome. The total Globulin and the Albumin to Globulin ratio can be increased or decreased due to several causes.

The total Bilirubin can be increased in hepatitis, hemolytic anemia, and blockage of the bile ducts, either the bile ducts within the liver or the bile duct that drains the gallbladder and the liver. That's what we mean when we say cholestasis or biliary obstruction. Direct Bilirubin is increased in the same things as total Bilirubin, but the ratio of direct to total gives us clues as to the causes. A syndrome called Gilbert's disease is one of the most common causes of a mildly elevated total Bilirubin found on a routine CMP. Although it's called a disease, it's familiar and doesn't cause any liver or health damage.

Alkaline Phosphatase can be increased in bone and liver disease and decreased in malnutrition and celiac disease.

The AST and ALT are often called liver enzyme tests. They don't measure liver function but give evidence of liver damage, but they can also be elevated in damage to other body parts. They can be increased in liver disease, muscle disease, pancreatitis, and excessive exercise.
More Details on Liver Function Tests

Liver function tests, also known as the hepatic panel, are laboratory tests that help measure how well the liver works. The liver carries out many vital bodily functions; when it is not working properly, levels of various enzymes, proteins, and other substances in the blood may rise or fall. Elevated liver enzyme levels may indicate liver damage caused by factors such as viral hepatitis, heavy alcohol consumption, or drug toxicity.

Alanine transaminase (ALT): formerly called SGPT, ALT is an enzyme usually present in liver cells. When these cells are damaged, ALT is released into the bloodstream. A normal ALT level for adult men is 0-50 International Units per liter (IU/L); levels are somewhat lower in women. While mild elevations are common (especially in people who exercise), an ALT level more than 2.5 times the upper limit of normal (ULN) is cause for concern. In general, upward or downward trends in ALT are more informative than a single measurement.

Aspartate transaminase (AST): formerly called SGOT, AST is another liver enzyme that may spill into the blood when liver cells are damaged. A normal AST level for adult men is 0-45 IU/L. AST levels may also be elevated in people with muscle damage.

Bilirubin: bilirubin is a pigment released when red blood cells are broken down. A normal bilirubin level is 0.1-1.5 mg/dL.An elevated level (hyperbilirubinemia) may indicate liver damage, impaired bile flow, or excessive red blood cell destruction. High bilirubin levels can lead to jaundice (yellowing of the skin and whites of the eyes).

Alkaline phosphatase (AP): elevated AP levels may signal obstructed bile flow or bone destruction. A normal level is 35-115 IU/L.

More Details on Kidney Function Tests

Blood urea nitrogen (BUN): nitrogen is a metabolic waste product usually filtered out by the kidneys and excreted in the urine. A normal BUN is 8-20 mg/dL. Elevations may indicate kidney dysfunction, high protein intake, or a fluid body imbalance (e.g., dehydration).

 Creatinine: this waste product of protein metabolism is also normally excreted by the kidneys. A normal blood creatinine level is 0.6-1.5 mg/dL. Elevated creatinine levels may indicate kidney damage. Creatinine is used in calculating creatinine clearance (creatinine clearance below 60 may display impaired kidney function).

Comprehensive Metabolic Panel Test FAQ

Now that you know what a CMP panel contains, let’s find answers to some of your questions.

1. How Can I Do the CMP Panel Test?

The test is done using a single blood sample. You go to a clinic and draw blood which will be analyzed in a medical laboratory. The doctors will perform the tests above to determine the levels of each substance in your bloodstream. You get the results back in a few business days and can compare them against standard reference values.

2. Is the Comprehensive Metabolic Panel Test Painful?

In most cases, it's not, but it depends on whether you have a fear of needles or not. Today's doctors are very efficient at drawing blood, so you might not even feel the sting when the needle enters your vein.

3. What If Some Variables or Enzymes Are Out of Normal Ranges?

Once the results are back, and some substances are off the charts, you can go to your healthcare provider for recommendations. If you have high glucose levels, your doctor might recommend starting an exercise regimen, which can increase insulin sensitivity and prevents diabetes.

You might need to eat more dairy products if your calcium levels are low. Avoid salty foods if your sodium levels are high. These recommendations are based on the specific results of each, so there’s no one-size-fits-all here—more information about what to do when you have low or high blood level values.

4. Do I Need to Fast Before Doing the Test?

Yes, fasting is mandatory for glucose level testing. Before doing this test, you should avoid eating and drinking anything other than water for 10-12 hours. 

5. Why Should I Do This Test?

It’s essential to do the test to get a broad overview of electrolytes and enzymes in your body. If some substances are not in the comprehensive metabolic panel normal ranges, you can take action and prevent more severe health complications. Plus, the test is affordable, quick, and easy to do, so why not take advantage of it?

6. How Can I Read and Interpret My Results?

The comprehensive metabolic panel normal ranges are published online, and you can find them with a simple Google search. You can also ask your doctor to interpret the results for you as well as checking out this engaging CMP guide on reading your comp metabolic panel.

Ready to Take the Test?

The comp metabolic panel provides one of the best ways to take control of your health. You can order the CMP test online from DiscountedLabs.com and find out how healthy you are in just a few business days, so why not try it?

This panel is the most inclusive of all offered on the site for men who want a wide picture of their health or who are considering starting testosterone replacement therapy.  It provides a baseline overview of your sex hormones, thyroid gland, adrenal function, metabolic function, cholesterol, prostate and overall health.  It includes:

• CBC (includes immune cells, red blood cells, and hematocrit)
• CMP-14 (Includes kidney and liver function, glucose and electrolytes)
• Lipid Panel (LDL, HDL, Triglycerides) FASTING REQUIRED
• Testosterone free and total (LC/MS assay with no upper limit)
• Estradiol, Ultra Sensitive (LC/MS assay)
• DHEA-sulfate (Dehydroepiandrosterone Sulfate)
• TSH (Thyroid Stimulating Hormone) 
• Free T3 (Free Triiodothyronine )
• PSA (Prostatic Specific Antigen)
• LH (Luteinizing Hormone)
• FSH (Follicle Stimulating Hormone)

Note: If you are using testosterone replacement, your LH and FSH will be suppressed. You may want to click the more affordable: TRT Male Hormone/Wellness Panel  and add other tests in the dropdown menu.

Suggested Reading: Testosterone Replacement Blood Test Targets

How does DiscountedLabs.com work: Click here

This is the lowest cost fatigue exploration panel offered anywhere. 

The causes of fatigue are multifactorial and could involve imbalances in several hormones. This panel includes most hormones and variables involved in the diagnosis and treatment of fatigue. Ordering this panel provides substantial cost savings when compared to ordering each test separately. The panel is useful for men and women. We suggest that you also talk to your physician about getting an order for a sleep study to determine if you have sleep apnea.

TESTS INCLUDED IN THIS PANEL:

TOTAL (LC/MS) AND FREE TESTOSTERONE (Equilibrium Dialysis) (No Upper Limit)

        Low testosterone can cause low energy and mood.

THYROID FUNCTION:

       Hypothyroidism is often an underdiagnosed cause of fatigue.

       Tests:

TSH

Free T3

Free T4

Thyroid Antibodies

GLUCOSE CONTROL:

       Hyper and hypoglycemia can affect energy levels.

       Test: A1c      

ANEMIA AND IMMUNE ISSUES: 

        Low hemoglobin or high hematocrit can cause fatigue. High white cell count can be indicative of infections which could also cause fatigue.

        Test panel:

Complete Blood Count (CBC) Test 

White Blood Cells (WBC)
 A high white blood cell count likely indicates that an infection is present somewhere in the body, whereas a low number might indicate that an infection or disease has slowed the ability of the bone marrow to produce them.

Red Blood Cells (RBC)
 A low red blood cell count can indicate anemia, which can lead to fatigue. 

Hemoglobin (HGB) and Hematocrit (HCT)
 A low hemoglobin number or hematocrit percentage are good indicators of anemia. A high hematocrit can cause blood thickening, high blood pressure and fatigue.

Mean Corpuscular Volume (MCV)
This test actually measures the size of red blood cells. Larger red blood cells may indicate anemia due to vitamin B6 or folic acid deficiency; smaller red blood cells may indicate anemia due to iron deficiency. 

Mean Corpuscular Hemoglobin (MCH) and Mean Corpuscular Hemoglobin Concentration (MCHC)
These tests measure the amount of hemoglobin in red blood cells. Both hemoglobin and hematocrit are used to calculate this number. Low levels indicate anemia.

Red Cell Distribution Width (RDW)

If anemia is suspected, based on other blood counts, RDW test results are often used together with MCV results to figure out what the cause of the anemia might be.

Platelets

IRON LEVEL, UTILIZATION, AND STORAGE:

        Low iron and/or ferritin can cause fatigue.

        Tests:

     Iron 

     TIBC (Total Iron Binding Capacity)

     Ferritin

ADRENAL FUNCTION:

       Adrenal insufficiency is a common cause of fatigue.

       Tests:

    Serum Cortisol

    DHEA (blood)

Not included but worth considering as a separate add-on to your shopping cart: Vitamin D and Vitamin B-12.

NOTE: If you are taking biotin, please stop it 72 hours before the blood draw since it may interfere with hormone blood tests.

Add-Ons for post-menopausal women: Estrogen and Progesterone.   Low estrogen levels many times found in menopause, often result in insomnia and night sweats. Diminished estrogen also causes irritability and mood swings in women which furthers exhaustion. Too little progesterone is also linked to fatigue in women.

BACKGROUND INFORMATION ON THIS PANEL: FATIGUED? : BUY THESE BLOOD TESTS TO FIND OUT WHY  

Blood Tests for Fatigue - What Are They and Why Do You Need One?

Feeling fatigued is one of the most prevalent symptoms people experience daily. This is not a problem if you just worked out hard or didn't sleep well for days. Excessive or chronic fatigue is a real thing, and it can have serious underlying causes.

This is when blood tests for fatigue come into play. It's possible to test a blood sample and find out why you're feeling constantly tired, even after a good night's sleep. Please keep reading to learn more about fatigue, what conditions it might hide, and how blood tests could help you.

The Main Symptoms and Characteristics of Chronic Fatigue

Fatigue itself is a symptom caused by something, but chronic fatigue is more complicated, and it might have accompanying symptoms. For example, many people feel tired without doing hard physical work. Others feel tired every day for weeks or even months on end.

This type of fatigue is also accompanied by a lack of motivation and energy. You aren't in the mood for anything, whether it's about going to work, spending time with your friends, or working out. If you cannot think of a potential reason for your chronic fatigue, chances are that it might have underlying causes.

Chronic fatigue is usually caused by lifestyle factors, medical conditions, or excessive physical exertion. If you haven't worked out hard recently, chances are that the other two aspects might cause your tiredness.

For example, excessive drinking and smoking can make you feel tired. Not eating a balanced diet rich in fruit, vegetables, and lean meats can also make you feel fatigued. Lastly, not getting at least 7 hours of sleep every night might be the culprit for your constant tiredness.

Potential Medical Conditions That Cause Fatigue

If you sleep enough, don't smoke cigarettes, and you eat a healthy diet but still feel fatigued, chances are that some underlying conditions are causing the problem. Certain medical conditions can leave you tired and feeling lethargic all day long.

For example, fibromyalgia is known for causing constant fatigue and mild pain in most muscles and joints of the body. The condition is rare, but it has no real cause and can decrease the quality of your life. It's possible to treat it using a particular medication and therapy, but you need to get a positive diagnosis for it first.

Arthritis is also known to cause excessive tiredness. This condition affects joints, tendons, and ligaments. It makes you feel lethargic and confused most of the time. Arthritis is common among seniors, but younger people can have it too.

Autoimmune disorders can also cause excessive fatigue. These are conditions that make the body fight itself. For example, celiac disease and lupus are prevalent autoimmune disorders that affect millions of people worldwide.

If you have an autoimmune disorder, a lot of your energy is spent by your body to fight your own cells and tissues. Not only can this do severe damage, but you also have no energy left for anything else.

Chronic disease such as diabetes also causes fatigue. That's because the insulin your body produces is no longer able to unlock cells to absorb glucose from the blood. As a result, you're left with a lot of sugar in the blood and none in cells where it's supposed to be to give you energy.

Finally, various types of cancers can also leave you without energy. That's because cells use this energy for abnormal mutations that can seriously threaten your health and life. Some cancers don't produce symptoms, and that's why you should run a blood test for fatigue as soon as possible.

How Can Blood Tests for Fatigue Help?

The problem with chronic fatigue is that it can have multiple causes. It's not easy to identify the exact reason you feel tired. For example, some people might live under constant stress, and their cortisol levels are very high regularly. This could cause excessive tiredness in the long run.

You might feel tired because you also have an underactive thyroid gland. The hormones produced by the thyroid are responsible for your body's metabolism and energy production. If the thyroid is not producing enough hormones, you might lack energy and feel tired most of the time.

Some people feel fatigued because they also have too much or too little sugar in their bloodstream. Glucose is also known as blood sugar, and it's a vital energy source. If your body cannot metabolize glucose properly, you might feel lethargic every day.

Another helpful test for fatigue is a complete blood count test panel. This type of test looks at your red blood cells, hemoglobin, hematocrit, and other useful parameters related to your blood. If you don't have enough red blood cells, this could cause anemia, which means you'll feel tired.

If you feel fatigued and it's not caused by the factors mentioned above, you might also want to do a testosterone test. This vital hormone controls your energy level, cognition, and mood. If you have less testosterone than normal, you might experience chronic fatigue.

As you can see, there are a lot of tests that can be used to determine the cause of your tiredness. Your doctor might run these tests individually, or you can order a comprehensive panel of tests that looks at all these aspects at once.

By doing so, you will know for sure that the root cause of your tiredness will be discovered and diagnosed accurately. The comprehensive panel is highly recommended for people who have struggled with chronic fatigue for months or even years.

Order Your Fatigue Test Today!

It's not fair to struggle with constant tiredness daily. Not only does it decrease the quality of your life, but it also reduces your productivity and makes you feel bad about yourself. You should order a fatigue blood test to see exactly why you're dealing with this problem.

Dihydrotestosterone (DHT) is a hormone that plays a key role in the development of male characteristics in people assigned male at birth (AMAB) [1]. DHT is an androgen hormone that stimulates the growth of facial, body, and pubic hair, as well as the growth of the penis, scrotum, and prostate during puberty in AMAB individuals [3]. It is derived from testosterone, which is present in both men and women [4].

However, DHT can also contribute to male pattern hair loss as it is thought to cause hair follicles to miniaturize [2]. Finasteride, which is commonly used to treat male pattern baldness, works by blocking the formation of DHT [5]. However, this product can come with some side effects.

DHT also plays a crucial role in men's overall health. It is necessary for an energetic and athletic body and is a vital component of a healthy hormone profile [8]. In fact, DHT is an effective mood booster and can have neurological effects that last longer than those of testosterone [6]. However, abnormal levels of DHT and other androgens can lead to various health problems, such as low libido, erectile dysfunction, and prostate issues [9].

Overall, DHT is a hormone that is essential for the development of male characteristics during puberty and for maintaining men's overall health. While it is important for various bodily functions, abnormal levels of DHT can lead to health problems, and treatments such as finasteride can help regulate DHT levels [5].

What is DHT ?

Dihydrotestosterone (DHT) is synthesized from testosterone in the prostate gland, testes, hair follicles, and adrenal glands by 5-alpha reductase. Dihydrotestosterone exerts its action similar to testosterone, which binds to and activates androgen receptors. Dihydrotestosterone is responsible for the formation of male primary sex characteristics and most male secondary sex characteristics during puberty, such as muscular growth, facial and body hair growth, and deepening of the voice.

This test is performed with the sensitive liquid chromatography/mass spectrometry assay that has no interference with supplements like biotin used in hair growth.

With the exception of estradiol, no hormone is more misunderstood than dihydrotestosterone, DHT. In fact, many men actually fear DHT, going out of their way to lower it and frustrate its biological activity. However, DHT is actually a critical hormone, one that men need for sexual and prostate health, cognitive function, skeletal strength – and many other reasons. Like everything in life, there are downsides to DHT, but the upside of healthy DHT levels far outweighs the challenges it can present.

DHT – Where it Comes From

The principal hormone produced in men is, of course, testosterone. When testosterone is produced by the testicles (or injected/absorbed by a man on testosterone replacement) an enzyme, 5-alphareductase (5-AR) sets to work converting a portion of that testosterone to DHT. This conversion actually prevents some portion of testosterone from reaching the androgen receptors in the brain, genitals, skin, and other tissues. Initially, that may sound as if the body is being deprived of a needed hormone – testosterone. However, for the most part, this conversion is actually in a man’s best interest. DHT binds much more efficiently to androgen receptors, estimates vary, but it would seem that DHT is 300 to 500 percent more efficient at reaching and binding to the receptors, and is far more potent than testosterone. If tissues were deprived of DHT, if 5-AR hadn’t done its job, there would be dramatic physiological changes.  While it is true that testosterone remains the primary, active androgen in muscle/muscle development, DHT is still critical for the full performance enhancing effects of testosterone. Specifically, the impact of DHT on the central nervous system which bring about increased neurological efficiency/strength.

DHT – Positive Effects

 To understand DHT’s androgenic properties, consider the following.

• Male Development – Physical and sexual development in the human male is DHT-dependent. DHT is responsible for the growth and development of the penis, the prostate, and the testicles. It not only helps with sex differentiation during fetal development, it also supports the changes that occur during puberty and adulthood.
• Libido – A healthy sex drive is supported by DHT. Men with optimal levels of the hormone report a far stronger drive than men with lower levels.
• Prostate Health – It seems that men with balanced levels of DHT may have fewer prostate health issues.
• Cognitive Function – One study indicated that administering DHT to men between the ages of 34 and 70 resulted in memory improvements. The androgenic properties of the hormone encouraged the retrieval of stored memories as well as the archiving or new ones. Low/lower levels of DHT were linked to a decline in cognitive function in elderly men.
• Blood Sugar Management – Higher levels of DHT help to reduce the risk of diabetes by controlling sugar levels and preventing hyperglycemia. DHT can improve insulin sensitivity, support efforts to lose weight, and may provide adjunctive support in treating diabetes.
•  Cardiovascular Health – Men with coronary artery disease may benefit from higher levels of DHT since lower levels of the hormone have been shown to actually increase the risk of cardiovascular disease. It may be a simple association – higher levels of DHT might lower the mortality associated with heart disease.
• Stroke Risk – Researchers followed a group of men for six years and learned that higher levels of both DHT and testosterone seemed to lower the risk of stroke. 
• Depression – In one study, men who used finasteride, a drug that blocks 5-AR and, thus, generate lower levels of DHT, had higher rates of depression than a control group. DHT may well be necessary to support mental and emotional health.
• Anti-Aging – Higher levels of DHT, testosterone, and estradiol seem to slow the decline associated with aging. Lower levels of all three hormones brought about cellular changes seen in the elderly. Higher levels were associated with “younger” cellular function.
• Bone and Skeletal Health – Along with estradiol, appropriate levels of DHT support and maintain bone density in men.

DHT – The Downside

The DHT story is strongly, but not universally, positive. The drawbacks of DHT must be considered.

• Baldness – Hair loss is probably the number one DHT – negative in the minds of most men who are involved in testosterone therapy.  Studies have shown that higher levels of DHT are linked to an increase in male-pattern baldness. In women, elevated levels of DHT can actually lead to male-like patterns of hair growth.
• Cancer – DHT is critical for the normal development of the prostate, but high levels of the hormone have been associated with prostate cancer risk. However, studies on DHT and prostate cancer are contradictory.
• Acne – Inflammatory acne flares have been linked to DHT.

 DHT – The Bottom Line...a Friend or Foe?

For men, DHT is clearly a friend, and an important one. However, like virtually every hormone in the body, the key to health is balance. If DHT levels drop too far, men open themselves to low libido. 

DHT is not likely to be tested in most men undergoing testosterone replacement therapy. Some clinicians fail to recognize the importance of DHT for men’s health and libido – and so they fail to monitor it. It’s entirely possible, even likely, that some men are not obtaining the maximum benefits of  testosterone replacement because (unbeknownst to them) their DHT levels are not optimal.

How to Increase DHT

There are natural ways to boost DHT levels if one is not on a testosterone replacement protocol. Here are a few things that can be done.

• Exercise more – particularly resistance training and high-intensity training.

• Increase your intake of caffeine, creatine, or green tea supplements.

• Boost the amount of zinc in your diet, either via the food you’re eating or via a supplement.

• Take a DHEA supplement if your DHEA blood level is low.  Get a DHEA blood test

• Lose weight.

• Optimize your testosterone blood level if low.

• Last but not least, use a scrotal testosterone cream. Applying compounded (alcohol free) testosterone cream to the testicular skin has been shown to increase DHT considerably.

How to Decrease or Block DHT?

It should be clear that the vast majority of men have no reason to suppress their DHT levels. However, Propecia is still prescribed regularly for men anxious about losing their hair. As was noted, Propecia will stop or suppress the 5-AR activity that produces DHT. By stopping or slowing the work of 5-AR, male pattern baldness, one of the possible, negative side effects that DHT can produce, may be prevented or arrested. Unfortunately, there is evidence that some men who take this medication may risk lowering their libido and mood.

For reasons still not clearly understood, this medication can produce a syndrome in some men very similar to those symptoms associated with hypogonadism. Loss of libido, weak erections, malaise, and fatigue plague many men even after they have stopped the use of the drug. While it’s true that no one wants to lose their hair, no man wants to wind up with what has come to be known as post-finasteride syndrome.

With proper attention, DHT can be not only a friend, but an ally in the search for optimal health. Don’t fear it – accept it and have it work to your advantage.

References:

[1] "What is DHT (dihydrotestosterone)? DHT (dihydrotestosterone) is a hormone that plays a key role in the sexual development of people assigned male at birth (AMAB). More specifically, DHT is an androgen — a hormone that stimulates the development of male characteristics." URL: https://my.clevelandclinic.org/health/articles/24555-dht-dihydrotestosterone

[2] "DHT is an androgen and helps give males their male characteristics. DHT is thought to cause hair follicles to miniaturize, and this contributes to male pattern hair loss. By the age of 50 years ..." URL: https://www.medicalnewstoday.com/articles/68082

[3] "Dihydrotestosterone (DHT) is an androgen, or male hormone, that promotes the growth of facial hair, body hair, and pubic hair during puberty in those assigned male at birth. It also plays a role in the growth of the penis, scrotum, and prostate.  These effects are similar to those of testosterone." URL: https://www.verywellhealth.com/what-is-dihydrotestosterone-4684657

[4] "DHT is derived from testosterone. Testosterone is a hormone that's present in both men and women. It and DHT are androgens, or hormones that contribute to male sex characteristics when you go..." URL: https://www.healthline.com/health/dht

[5] "Finasteride: Finasteride (typically referred to as Propecia) obstructs the formation of DHT (dihydrotestosterone). "DHT is a male androgen hormonal agent which contributes to hair loss by making hair follicles short and thin," states Green. ""Hair grows in 3 phases, and DHT interrupts the hair growth cycle (anagen stage). As a result of ..." URL: https://thebiohack.org/what-is-dht-and-its-role-in-hair-loss/

[6] "DHT is an effective mood booster, for the brain to function at its best, it relies on optimum levels of all the main sex hormones ( Testosterone, DHT and Estrogen). It has been shown that the neurological effect of DHT can last many times longer that that of Testosterone." URL: https://lowtestosteroneexpert.com/the-effects-of-dht/

[7] "What is DHT? Dihydrotestosterone (DHT) is a male sex hormone with powerful androgenic properties. It plays a crucial role during puberty and is largely responsible for the development of adult male characteristics. Things like: Deeper voice, Muscle development Body hair, etc. DHT is quite literally derived from testosterone." URL: https://androgenhacker.com/dht

[8] "DHT is a natural hormone scientifically known as dihydrotestosterone. In men, it is necessary for an energetic, athletic body and a vital component of a healthy hormone profile. The primary form of DHT production comes from the enzyme 5-alpha-reductase (5-AR) which forms DHT from testosterone within the testicles and prostate gland of men." URL: https://itestosterone.com/dht-hormone-benefits/

[9] "In this article, we explain what testosterone and DHT are and provide an overview of how these hormones are produced and regulated by the body. We also discuss the role of these androgens in men's health and what can go wrong when androgen levels are abnormal. Lastly, we review treatments for low testosterone." URL: https://xyonhealth.com/article/role-of-testosterone-and-dht-mens-health/

[10] "DHT is an essential male hormone, not just for libido, or feeling manly, but for general health as well. DHT is synthesized from: Testosterone through the enzyme 5 alpha reductase (5AR) 17-hydroxypregnenolone and 17-hydroxyprogesterone in what is termed the "backdoor" pathway 5α-androstane-3α, 17-β-diol (dihydroandrosterone/3α-diol) via the intracrine reverse synthesis pathway (3α ..." URL: https://men-elite.com/2020/09/29/the-truth-on-dht-what-the-research-shows/

This panel includes important tests usually prescribed for anyone living with Type 1 or Type 2 diabetes. It includes A1c, CMP, Urinalysis, Insulin and Glucose Tolerance Test (GTT)- 2 samples.

Diabetes is a group of diseases that result in blood sugar (glucose) levels that are too high.

Type 1 Diabetes is characterized by the body failing to produce insulin.

Type 2 Diabetes is characterized by failing to produce enough insulin for proper function or by the body not reacting to insulin. Approximately 90 percent of diabetes cases are Type 2.

Gestational diabetes affects pregnant women. It occurs when their bodies have very high glucose levels and not enough insulin to transport it into cells. Often women with gestational diabetes have no symptoms, so testing is important if you are considered an at-risk patient.

A1C Test

The A1c test works by measuring the hemoglobin A1c level. Hemoglobin is stored in the red blood cells. When glucose levels are high, the sugar starts to combine with the hemoglobin. It takes the body 8 to 12 weeks to bring hemoglobin A1c levels back to normal. Therefore, if hemoglobin A1c levels are high, that means that there has been a high level of glucose in the blood over the last 2 to 3 months.

Comprehensive Metabolic Panel (CMP):

Let's go over the cmp blood tests :

The Serum Glucose test: Serum glucose levels may be high due to diabetes mellitus, strenuous exercise, increased epinephrine, pancreatic disease or an endocrine disorder. A high serum level may also be related to acute myocardial infarction or severe angina, chronic liver disease, or chronic renal disease.

The Uric Acid test: High uric acid levels may indicate gout, renal failure, leukemia, lymphoma, psoriasis, polycythemia, multiple myeloma, kidney disease, and or chronic lead nephropathy. Associated with hyperlipidemia, obesity, hypertension, arteriosclerosis, diabetes mellitus, hypoparathyroidism, acromegaly, and liver disease.

The BUN, Blood Urea Nitrogen, can be abnormal in kidney disease, dehydration, and heart failure, as well as malnutrition and liver disease.

The Serum Creatinine is a measure of kidney function. The BUN to Creatinine ratio can give information on the possible cause of the kidney dysfunction, say heart failure or dehydration or decreased kidney blood flow

The Serum Sodium can be increased in dehydration. The Serum Sodium can be decreased in diuretic therapy and in the syndrome of inappropriate antidiuretic hormone abbreviated, SIADH.

The Serum Potassium can be increased in adrenal insufficiency and acute renal failure, as well as with an inappropriate combination of medicines. Potassium could be decreased in primary aldosteronism, diuretic therapy, and renal tubular acidosis.

The Serum Chloride: High chloride levels may be attributed to dehydration, renal tubular acidosis, acute renal failure, diabetes insipidus, metabolic acidosis associated with prolonged diarrhea with loss of nahco3, respiratory alkalosis, and some cases of primary hyperparathyroidism. Low serum chloride levels may be due to excessive sweating, prolonged vomiting from any cause or gastric suction, persistent gastric secretion, salt-losing nephritis, aldosteronism, potassium depletion associated with alkalosis, respiratory acidosis

Carbon Dioxide: High levels may indicate respiratory acidosis caused by poor gas exchange or depression of respiratory center; generalized respiratory disease; metabolic acidosis (after severe vomiting in pyloric stenosis, hypokalemic states, or excessive alkali intake). Low levels may indicate compensated respiratory alkalosis, metabolic acidosis in diabetes mellitus, renal glomerular or tubular failure, renal tubular acidosis and intestinal loss of alkali with coexisting increase in c1 and normal anion gap

Serum Calcium: High blood calcium levels may indicate primary and tertiary hyperparathyroidism, malignant disease with bone involvement (in particular metastatic carcinoma of the breast, lung, kidney, multiple myeloma, lymphomas, and leukemia), vitamin d intoxication, milk-alkali syndrome, Paget’s disease with immobilization, thyrotoxicosis, acromegaly, diuretic phase of acute tubular necrosis or dehydration. Low levels of calcium may indicate hypoparathyroidism; vitamin d deficiency, chronic renal failure, magnesium deficiency, prolonged anticonvulsant therapy, acute pancreatitis, anterior pituitary hypofunction, hypoalbuminemia, or inadequate nutrition.

Serum Phosphorus can be increased in acute or chronic renal failure and decreased in malabsorption and vitamin D deficiency. Serum phosphorus concentrations have a circadian rhythm (highest level in late morning, lowest in evening) and are subject to rapid change secondary to environmental factors such as diet (carbohydrate), phosphate-binding antacids, and fluctuations in growth hormone, insulin, and renal function. High levels may indicate osteolytic metastatic bone tumors, myelogenous leukemia, milk-alkali syndrome, vitamin d intoxication, healing fractures, renal failure, hypoparathyroidism, pseudohypoparathyroidism, diabetes mellitus with ketosis, acromegaly, portal cirrhosis, pulmonary embolism, lactic acidosis or respiratory acidosis.

The total Serum Protein can be increased in multiple myeloma and sarcoidosis, and it can be decreased in chronic glomerulonephritis, which is a type of chronic renal disease.

The Serum Albumin can be decreased in liver disease, cirrhosis, and in nephrotic syndrome. The total Globulin and the Albumin to Globulin ratio can be increased or decreased due to a number of causes.

The total Bilirubin can be increased in hepatitis, hemolytic anemia, and in blockage of the bile ducts, either the bile ducts within the liver or within the bile duct that drains the gallbladder and the liver. That's what we mean when we say cholestasis or biliary obstruction. The direct Bilirubin is increased in the same things as the total Bilirubin, but the ratio of direct to total gives us clues as to the causes. One of the most common causes of a mildly elevated total Bilirubin found on a routine CMP is a syndrome called Gilbert's disease. Although it's called a disease, it's common, and it doesn't cause any liver damage or any health damage.

The Alkaline Phosphatase can be increased in bone disease and liver disease and decreased in malnutrition and celiac disease.

The AST, and ALT are often called liver enzyme tests. They don't measure liver function, but rather give evidence of liver damage, but they can also be elevated in damage to other parts of the body. They can be increased in liver disease, muscle disease, pancreatitis, and excessive exercise.

Urinalysis

The Urinalysis test panel screens for a variety of conditions including urinary bladder disease, kidney disease and diabetes. Tests included: Color, Appearance, Specific gravity, pH, Protein, Glucose, Occult blood, Ketones, Leukocyte esterase, Nitrite, Bilirubin, Urobilinogen, and Microscopic examination of urine sediment.

About one-third of people with diabetes have problems with their kidneys. But early and tight control of your blood sugar and blood pressure, plus help from certain medications, can keep these organs working like they should. To check for problems, this test measures if protein is present in your urine, called microalbuminuria. It shows up when small amounts of albumin (the main protein in your blood) seep into your pee. Without treatment to slow the leak (usually blood pressure medications), your kidneys could be damaged and eventually fail.

Insulin Level

Insulin is a substance produced by the pancreas to help stabilize blood sugar levels. This substance acts as a "key" that opens up the cells in your body, allowing them to absorb glucose and use it for energy production.

A typical insulin blood level between meals is 8–11 μIU/mL (57–79 pmol/L)

Glucose Tolerance Test (GTT), Two-hour

The glucose tolerance test is a medical test in which glucose is given and blood samples taken afterward to determine how quickly it is cleared from the blood. The test is usually used to test for diabetes, insulin resistance, impaired beta cell function, and sometimes reactive hypoglycemia and acromegaly, or rarer disorders of carbohydrate metabolism. In the most commonly performed version of the test, an oral glucose tolerance test (OGTT), a standard dose of glucose is ingested by mouth and blood levels are checked two hours later.

The electrolyte panel includes: Carbon dioxide, chloride, potassium, and sodium  

What Are Electrolytes?

Electrolytes are electrically charged minerals that help the body manage chemical reactions and maintain the balance between fluids. These substances are located in the fluid in and around the body's cells (intracellular and extracellular fluid). The human body is roughly 60% water, meaning almost every fluid and cell contain electrolytes. They also help the brain send signals to one's muscles, allowing them to move and contract. This is possible since many chemical elements can naturally hold a positive or negative charge. Once those elements are dissolved in liquid, it grants the fluid the ability to conduct electricity. The body then uses positively and negatively charged ions to transport critical chemical compounds in and out of cells. Electrolytes help control nerve and muscle activity, heart rhythm, and other vital functions. Without electrolytes, the body would not be able to maintain homeostasis. Severe disruptions in electrolyte levels can lead to neurological and cardiac complications, resulting in a medical emergency unless quickly resolved.

What Is an Electrolyte Panel?

An Electrolyte Panel is a blood test designed to measure the body's primary electrolytes levels. They are frequently used in routine blood screenings to diagnose fluid imbalances. The test can also be referred to as an electrolyte blood test or serum electrolyte test. Several factors may cause an electrolyte imbalance

• Burns
• Cancer
• Dehydration or overhydration
• Diabetes
• Heart, liver, or kidney disease
• Substance abuse

Some tests are designed to measure the levels of only one kind of electrolyte. Discounted Labs' Electrolyte Panel includes four out of the seven primary minerals:

• Bicarbonate moves carbon dioxide through the bloodstream and balances the body's acid/base levels.
• Chloride helps regulate the amount of fluid in the body and maintain healthy blood pressure.
• Potassium facilitates proper heart, nerve, muscle, and metabolic function.
• Sodium controls fluid levels and assists in nerve and muscle function.

Do I Need an Electrolyte Panel?

Your healthcare provider may order an electrolyte panel for a number of reasons. They are commonly used in ordinary checkups to gauge overall health. They are also invaluable in monitoring kidney and liver function, checking heart functionality, monitoring glucose levels in diabetic patients, and diagnosing endocrine conditions. Electrolytes serve a host of essential bodily functions, including maintaining proper pH levels, allowing muscle contractions (including the heartbeat), forming new tissues, and assisting in blood clotting. As these functions are vital to a healthy body, an imbalance of electrolytes has the potential to result in serious medical complications. Imbalances are commonly caused by a significant loss in bodily fluids, such as sweating or vomiting. Some immediate symptoms of an electrolyte imbalance are cramps, dizziness, irregular heartbeat, and mental confusion. If these symptoms persist after replenishing fluids, it may be worth taking an electrolyte panel to pinpoint what minerals you are deficient in to begin treatment. 

How Should I Prep for an Electrolyte Panel?

Some blood tests require you to fast for a predetermined time leading up to sample collection; however, this is not the case for electrolyte panels. There are no special preparations needed to take this test. Know that results will vary based on which electrolytes do not fall within the normal range. It is important to remember that just because certain electrolyte levels are too high or low does not mean one has a medical emergency requiring treatment. Certain medicines such as antacids or blood pressure medication can impact the results of an electrolyte panel. Often, the patient must replace fluids they've lost through diarrhea and/or vomiting.

How Should I Interpret My Electrolyte Panel Results?

Age, sex, and preexisting health factors can affect your test results. Electrolytes are measured in millimoles per liter (mmol/L). The general normal ranges for each electrolyte are:

• Bicarbonate: 22 to 30 mmol/L
• Chloride: 97 to 105 mmol/L
• Potassium: 3.7 to 5.1 mmol/L
• Sodium: 136 to 144 mmol/L

While abnormal results can be scary to receive, they are not an immediate cause for concern and can fluctuate regularly. Results are typically more beneficial when examining trends from multiple tests over time. This gives the patient a more comprehensive understanding of their electrolyte levels in the grand scheme of things, as opposed to a single data point. Depending on the result of the electrolyte panel, your healthcare provider may other tests known as "blood gas" and "anion gap" tests. The blood gap test measures oxygen, carbon dioxide, and acidity levels in the blood to locate the cause of an acid-base imbalance. The anion gap test measures the difference between the amount of positively and negatively charged electrolytes in the body. As electrolytes depend on a balance of positive and negative charges to transmit signals throughout the body, an anion gap that is too high or low could signify a more severe health problem.

Sources

Balcı, A. K., Koksal, O., Kose, A., Armagan, E., Ozdemir, F., Inal, T., & Oner, N. (2013). General characteristics of patients with electrolyte imbalance admitted to emergency department. World journal of emergency medicine, 4(2), 113.

Cabezas, A. C., & Rojas, Y. C. (2006). ELECTROLYTE PANEL TESTS: AN INFORMATION SYSTEM FOR REGISTRATION AND CONSULTATION.

Costill, D. L., Cote, R., & Fink, W. (1976). Muscle water and electrolytes following varied levels of dehydration in man. Journal of Applied Physiology, 40(1), 6-11.

Maughan, R. J. (1991). Fluid and electrolyte loss and replacement in exercise. Journal of Sports Sciences, 9(S1), 117-142

Wathen, J. E., MacKenzie, T., & Bothner, J. P. (2004). Usefulness of the serum electrolyte panel in the management of pediatric dehydration treated with intravenously administered fluids. Pediatrics, 114(5), 1227-1234.

How to Buy Lab Tests on Discounted Labs

This is Discounted Labs most comprehensive blood test panel for men. It includes:

· Testosterone, Total and Free LC/MS (no upper limit) (involved in libido, stamina, lean mass, cognitive function, etc. )

· Ultra Sensitive Estradiol (involved in libido, bone density, lipids, and high levels linked to gynecomastia)

· IGF-1 (insulin growth factor) (a metabolite of growth hormone)

· Prolactin (involved in low testosterone, low libido, erectile dysfunction)

· DHT (dihydrotestosterone- involved in libido, acne and hair loss. Low levels have been linked to gynecomastia)

· DHEA-S (dehydroepiandrosterone sulfate) (involved in stamina, cognitive function, etc.)

· PSA (prostate specific antigen) (a marker of prostatitis or prostate cancer)

· SHBG (sex hormone binding globulin) (a strong binder that limits sex hormones)

· Lipids (LDL, HDL, and triglycerides) (involved in heart disease) FASTING REQUIRED

· CBC (complete blood count including hematocrit)

· CMP (comprehensive metabolic panel including kidney and liver function)

· Thyroid Function (involved in stamina, fat, cognitive function, libido, ED, etc.):

o TSH

o Free T3

o Free T4

Elite Male Blood Test Panel

Are you looking for a unique, all-in-one solution to measure the hormone levels in your body? If the answer is yes, then the Elite Male Blood Test Panel might be exactly what you need!

This panel is specially designed to measure virtually all important hormones in a man’s body, leaving nothing out, so you don’t have to buy additional panels.

The Elite Male Blood Test Panel tests everything from testosterone levels, IGF-1, DHEA-sulfate, hematocrit, estradiol, prolactin and more.

What are the advantages of the Elite Male Blood Test Panel?

Besides having the possibility to measure the most important hormones in your body using a single blood sample, this comprehensive panel also comes with other benefits such as:

1. Save time and effort – you don’t have to spend money on other panels or look for specific panels separately

2. Confidential and secure – order the panel online, visit a nearby lab to draw blood and get your results in a couple of business days

3. Know if you’re predisposed to certain illnesses – doing periodic checkups is highly recommended as these tests can identify potential predispositions to various diseases. For example, if you have high fasting glucose levels, you might be more prone to develop type 2 diabetes in the future, and you can prevent that with the right treatment

4. Best bang for your buck – the market offers this panel for at least $800 on average. At DiscountedLabs.com, you can have it at a much lower price

5. Have more peace of mind – your health is more important than anything! By getting this tests panel, you know you have done everything to improve your health and wellbeing

What does the Elite Male Blood Test Panel contain?

As mentioned earlier, this comprehensive panel can measure all the important hormones in your body, helping you find out in which ones there might be a deficiency.

For example, this panel tests the total and free testosterone levels, estradiol, thyroid hormones, metabolic hormones such as triglycerides, red blood cells, white blood cells, etc.

Let’s take a closer look at each of these hormones and substances to find out how they can influence the male body.

Testosterone lab test

One of the most important hormones in a man's body is, of course, testosterone. The Elite Male Blood Test Panel looks at the total and free testosterone levels to determine if deficiencies are present.

The normal testosterone level in men is between 350ng/dL and 1,000ng/dL. Testosterone primarily influences muscle development, sexual desire, mood, motivation, and brain function.

Low testosterone levels don’t only negatively impact one’s sexual desire and motivation, but they also have a strong influence in other areas of life.

It has been determined that testosterone can have anti-depressant qualities and it can improve spatial awareness. Low testosterone can also be closely linked to feelings of anxiety and low coping skills.

If low testosterone levels are discovered in men, this can be corrected with treatments such as testosterone replacement therapy (TRT). Testosterone can be applied as gels, creams, pellets or injections.

How to increase testosterone levels

Other methods to increase testosterone levels include:

• Minimize cortisol levels (try to get quality sleep and relax more often by practicing yoga, reading or mindfulness)
• Eat more lean protein and high-quality, complex carbs
• Lift weights – this will also enhance bone density
• Lose weight if you are overweight.

Estradiol test

This comprehensive panel also performs includes an ultrasensitive estradiol test.  This type of test is more thorough than the regular estradiol test and tries to determine the levels of this sex hormone more accurately.

Estradiol is a female sex hormone present in small quantities in a man’s body. If the quantity of this hormone is too little, the man might experience drops in libido and bone density. If it is in higher-than-normal quantities, estradiol can cause gynecomastia (man boobs), among other problems.

For example, one of the most popular consequences of having too much estradiol in the body (in the presence of low testosterone levels) consists of an increased likelihood to develop erectile dysfunction.

How to normalize estradiol in men

One of the best ways to normalize estrogen (including estradiol) levels is by eating more quality foods such as cruciferous vegetables. Some of these veggies include spinach, cabbage, cauliflower, kale, broccoli, Brussels sprouts, and others. Losing body fat, decreasing TRT dose, splitting TRT injections in smaller more frequent doses, and low dose aromatase inhibitors may also help to normalize high estradiol in men.

IGF-1 test

IGF-1 (Insulin-like growth factor 1) is a protein with a major influence on human health and wellness. This is a metabolite of growth hormone, and it is vital during childhood for proper development of muscles, bones, organs, and tissues.

The insulin-like growth factor hormone is also paramount during adulthood. Optimal levels of IGF-1 can decrease inflammation and increase the number of antioxidants in the body which in turn can increase longevity.

Low levels of IGF-1 have been associated with endothelial dysfunction which might lead to cardiovascular diseases.

How to Increase IGF-1

The good news is that increasing IGF-1 can be done relatively easy by engaging in frequent exercise routines, getting high-quality sleep, and by practicing intermittent fasting.

Intermittent fasting, in particular, can have multiple other positive effects on the body, besides enhancing IGF-1 levels.

Prolactin test

Prolactin is another important hormone tested by the Elite Male Blood Test Panel. This protein is produced by the pituitary gland as well as spleen and thymus.

It is involved in over 300 body processes, and it can be correlated with low testosterone, low libido, and erectile dysfunction in men if it is present in abnormal quantities in the body.

For example, a high secretion of prolactin can impair the normal functioning of the testicles which means that the reproductive system is affected.

Things that Can Increase Prolactin Levels

Prolactin is essential in the body of a man, but only in normal quantities. Elevated prolactin levels can be problematic, and they are usually caused by certain medications as well as pituitary gland tumors. You can decrease prolactin with medications called ergot derivatives.

DHT test

DHT (dihydrotestosterone) is produced in the liver, brain, seminal vesicles, hair, and other organs. The enzyme 5α-reductase triggers the production of DHT from testosterone.

DHT plays a vital role in the development of secondary male sexual characteristics such as pubic and facial hair growth. During puberty, it significantly influences the maturation of the penis, and in adulthood, it is closely linked to a man’s overall sex drive and libido. Low levels of DHT can also lead to the development of gynecomastia.

A high concentration of DHT might kickstart the development of androgenetic alopecia which is a condition that manifests through excessive hair loss. It has been discovered that the hair follicles of people who have androgenetic alopecia are more sensitive to DHT and they react differently.

Tips to normalize DHT in the body

There are several dietary adjustments you can make to normalize the levels of DHT in your body. For example, you can:

· Eat a lot of tomatoes which are naturally rich in lycopene which is a known DHT blocker and will reduce its levels

· Drink more green tea – this beverage has a high level of antioxidants which will normalize DHT levels fairly quickly

· Eat almonds and nuts – these snacks contain zinc and L-lysine which are known for reducing the levels of DHT in both men and women

· Take supplements such as pumpkin seed oil or palmetto pills

· Drink less coffee – a cup of coffee a day is not a problem, but drinking 2-3 or more cups can increase DHT levels

· Creatine supplements have also been shown to increase DHT blood levels

· For men with low DHT blood levels, some physicians prescribe a scrotal testosterone cream that are applied to the scrotum. This area produces more DHT than regular skin.

DHEA-S test

DHEA-S (Dehydroepiandrosterone sulfate)is the most abundant steroid in the human body. It is produced by the adrenal glands which are situated just above the kidney.

This steroid has a great influence on brain function and stamina. If the DHEA-S levels are insufficient, this can indicate a problem with the adrenal or pituitary glands. Physicians recommend DHEA supplements for people with low DHEA levels in the blood.

PSA test

PSA (prostate specific antigen) is a marker of prostate health and very important to test in men of all ages. This enzyme is produced in the prostate gland and allows the sperm to swim freely and enter the uterus during unprotected intercourse with a female partner.

Men with healthy prostates have small quantities of PSA, but abnormally elevated PSA levels might indicate prostate cancer or prostate infections.

SHBG test

SHBG (sex hormone binding globulin) is capable of influencing the bioavailability of sex hormones such as testosterone and estradiol.

If the SHBG levels in men are too high, the free testosterone levels that circulate in the bloodstream will be lower, and this can lead to androgen deficiency.

Lipids test

The Elite Male Blood Test Panel also runs lipid tests to determine the amount of HDL (good cholesterol), LDL (bad cholesterol), and triglycerides in the body.

Cholesterol is paramount for the creation of cells, but if it is present in abnormal quantities in the bloodstream, this can lead to cardiovascular diseases.

Tips to normalize cholesterol levels in the body

• Studies show that supplementing with vitamin D and calcium at the same time can significantly improve cholesterol levels.
• Similarly, supplementing with niacin can lower LDL cholesterol and increase HDL cholesterol. However, niacin treatments should only be administered under doctor’s supervision as this substance (also known as B3 vitamin) can be liver toxic in excessive quantities.
• Another great way to reduce cholesterol levels is to eat garlic. Although it might cause bad breath, the anti-inflammatory properties of garlic will significantly decrease cholesterol levels to normal values.
• Physical exercise also has an important influence on the LDL, HDL, and cholesterol levels. For example, a single exercise session managed to lower the levels of triglycerides by 18% after 24 hours in untrained hypercholesterolemic men.
• The HDL cholesterol was also increased by approximately 10% after 24 hours of exercise and remained high for a longer period.
• The triglycerides are also important and closely linked to heart problems. Decreasing sugar and alcohol intake may help to reduce triglycerides.
• It has been discovered that a high fiber intake can have a positive influence on lipids status. Therefore, consuming more foods which have a high fiber value (whole grains, apples, lentils, beans, etc.) can be a good way to reduce cholesterol and blood sugar levels.

Tips on improving triglyceride levels

There are a couple of quick dietary changes you can make to ensure that your triglyceride levels drop to normal levels. For example:

· Make sure that you minimize sugar intake – get your sugar from fruits instead of cookies, candies, donuts, pies, ice cream or other refined sugar sources

· Eat fatty fish one or two times per week – salmon and mackerel are considered to be fatty fish

· Avoid trans fats altogether – these can be found in margarine as well as other refined carbs

CBC panel test

CBC (complete blood count) is also measured as part of this panel, including hematocrit which means the volume of red blood cells in the bloodstream.

Several elements are measured in a CBC test such as the amount of red blood cells (which are vital for carrying oxygen and nutrients to tissues and organs), white blood cells (responsible with neutralizing viruses and bacteria), RDW (red blood cell distribution), MCV (mean corpuscular volume), and others.

A high MCV count can indicate several health problems such as liver disease, a vitamin B12 deficiency or hypothyroidism.

Blood platelets are also measured during a CBC test. These cells play an important role in blood clotting. Men who have low platelet levels might be at risk of excessive bruising or bleeding as a result of an injury.

CMP test

CMP (comprehensive metabolic panel) looks at a range of metabolic variables which impact the liver and the kidneys.

For example, the albumin levels are measured to determine if there is a sign of liver damage. Sodium and potassium are two important electrolytes which are measured to determine if there is a proper water balance in the body.

Some of the variables measured by the CMP panel include:

· Glucose

· Calcium levels

· Sodium

· Potassium

· Chloride

· CO2

· Albumin

· Total protein

· Blood urea nitrogen

· Creatinine and eGFR

· Bilirubin

· ALP, ALT, and AST (liver tests)

Glucose is the body's main energy source. It is also known as blood sugar content. When the glucose level is too high, this might indicate a predisposition to type 2 diabetes which is a life-threatening disease.

Tips on improving glucose levels

Imprving glucose blood levels can be done relatively easy, but one should be consistent to reach normal glucose levels. For example:

· Avoid refined flour – stay away from most bread, pasta, and anything containing refined flour

· Avoid high-fructose corn syrup – this type of sugar can significantly enhance blood glucose levels

· Reduce alcohol consumption – many alcoholic drinks are sweetened, or they are consumed in combination with sweetened drinks such as Red Bull. Drink less alcohol, and you’ll be fine

Calcium is important for bone density and teeth health. Low levels of calcium in the body, especially in aging men, can indicate a predisposition to osteoporosis and other bone ailments.

On the other hand, too much calcium in the bloodstream can lead to hypercalcemia which can be caused by overly active parathyroid glands, among other causes.

Hypercalcemia can lead to muscle fatigue, excessive urination, and osteoporosis. Lowering calcium levels can be done by drinking plenty of water and by doing strength training which helps improving bone density. If it is caused by high parathyroid hormone, your doctor will prescribe medications to normalize it.

Electrolyte Tests

Chloride and CO2 (carbon dioxide) help to maintain the proper acid-base balance in the body. Very acidic blood circulating through the body might indicate respiratory problems (the lungs aren't able to properly eliminate CO2), alcohol overuse as well as nervous system issues.

Sodium and potassium are two important electrolytes which help to maintain proper water balance in the body. They also sustain correct muscle function and regulate other processes.

Too much potassium can be a sign of kidneys problems since these organs strive to eliminate excessive potassium from the bloodstream. Too much sodium can also make the blood too acidic which leads to numerous other health problems

However, some people don’t have enough potassium in their bodies, but this can be usually corrected through diet.

Tips on improving potassium levels

Try eating potassium-rich foods such as beans, non-fat yogurts, leafy greens, and sweet potatoes. If you love fruit, oranges and bananas are high in potassium too.

Protein Test

Albumin is a protein produced by the liver, and it plays a vital role in muscle strength. Studies show that low albumin levels can be independently associated with a progressive decline in muscle strength in both men and women.

On top of albumin, the Elite Male Blood Test Panel also measures the total levels of serum proteins in the body. This blood test variable can be an important indicator of muscle health since protein is the building block of muscle tissue.

Waste products Test

Blood urea nitrogen (BUN) is an indicator of kidney or liver disease. Urea is produced as a result of metabolizing proteins and breaking them down into amino acids. This process generates ammonia which is then converted to a less toxic substance called urea.

Urea and nitrogen are both parts of the ammonia and can be used together – urea nitrogen. If the levels of urea nitrogen in the bloodstream are high, this can indicate serious liver damage or a kidney issue.

Creatinine is a byproduct of creatine which is an essential hormone for producing muscle energy. Approximately 2% of creatine is transformed into creatinine on a regular basis.

Normal creatinine levels are between 0.6mg/dL and 1.2mg/dL. The job of the kidney is to filter out the circulating creatinine and dispose of it safely. If the creatinine levels are elevated, this might indicate kidney disease. A creatinine level of approximately 5mg/dL indicatessevere kidney problems.

Bilirubin is another waste product created by the liver as a result of recycling red blood cells. High levels of bilirubin can indicate liver damage because the liver is not capable of eliminating it completely.

Symptoms of high bilirubin include the yellowing of skin and eyes, a condition called jaundice.

The ALP, ALT, and AST are enzymes found primarily in the liver. High levels of some of these enzymes might indicate liver damage.

Thyroid test

There are three important hormones measured by the thyroid test – TSH (thyroid stimulating hormone), T3, and T4. The TSH is produced by the pituitary gland while the other two are produced by the thyroid gland itself.

These hormones regulate multiple body processes and are directly involved in numerous metabolic functions. Improper thyroid hormone levels might result in fatigue, erectile dysfunction, low libido, and more.

For example, the normal TSH levels are between 0.4 and 4.9 mU/L, and they can be influenced by various factors such as stress, diet, medication, exercise level, etc. Some physicians use a TSH level of 2.5 as a cut off to further investigate potential hypothyroidism.

Low TSH levels indicate hyperthyroidism. High TSH levels indicate hypothyroidism. Both these conditions can be treated with the correct medication, but it is important to quantify the TSH levels first.

Similarly, low free T3 levels might indicate hypothyroidism or other significant ailments which might require hospitalization. Low free T4 levels in combination with low TSH levels might indicate that there is a problem with the pituitary gland.

How to Place a Lab Test Order on DiscountedLabs.com?

Keep in mind that an ounce of prevention is worth a pound of cure. The Elite Male Blood Test Panel provides everything you need to do a complete health checkup and determine if there are hormonal deficiencies in your body.

The next thing to do is to:

1. Order the panel online

2. Wait for your appointment at a nearby lab

3. Draw blood

4. Wait for your results – usually; you'll have them in a couple of business days

5. Visit a professional healthcare provider who will interpret the results for you and make appropriate recommendations

6. Put those recommendations into practice – this might mean to follow certain treatments to reduce/increase hormone levels, etc

7. Enjoy your new and healthier life!

The Elite Male Blood Test Panel strives to bring you the most important hormonal tests that you need to learn valuable information when it comes to your health.

Suggested Reading: Testosterone Replacement Blood Test Targets

This Erectile Dysfunction ED panel measures hormones that can affect erectile function. Tests included are:

• Prolactin: High levels have been linked to ED and low libido.
• Total and Free Testosterone (LC/MS, no upper limit): Low levels have been linked to ED and low libido.
• Ultra Sensitive Estradiol: High or low levels have been linked to low libido.
• DHT: Low levels have been linked to low libido.
• TSH: High levels have been linked to hypothyroidism which has been linked to ED and low libido.
• Free T3: Low levels have been linked to ED and low libido.
• Free T4: High or low levels in the presence of low free T3 may be linked to low libido.

What is ED and How Can it Be Treated?

Erectile dysfunction (also known more commonly as impotence or sexual dysfunction) is the inability to maintain a sufficiently rigid erection for a satisfying sexual experience.

According to the Global Survey of Sexual Attitudes and Behaviors, erectile dysfunction affects approximately 5-28% of men aged 40-80 years. The study was done on adults from 29 different countries.

Erectile dysfunction (ED) is a condition where a man experiences difficulty in achieving or maintaining an erection during sexual intercourse. It affects approximately 5-28% of men aged 40-80 years, according to the Global Survey of Sexual Attitudes and Behaviors. ED can be caused by a variety of factors, such as medication, endocrine disorders, neurogenic disorders, vasculogenic disorders, and psychogenic factors.

To diagnose ED, doctors may use questionnaires or lab testing. Before treating ED, doctors assess the health of the cardiovascular system to determine if it is healthy enough for sexual activity. Lifestyle changes, such as quitting smoking, reducing alcohol consumption, and exercising regularly, can also help manage ED.

Erectile dysfunction causes

This type of health problem can have multiple causes and the most common ones are:

• Pharmacologic – caused by different types of medications such as antidepressants, analgesic narcotics, antiulcers, antihypertensives, etc. There are more than 200 medications which have been associated with sexual dysfunction and some of them decrease the testosterone levels which in turn lower erection rigidity, sex drive, etc.
• Endocrinologic – this refers to testosterone deficiency and hypogonadism. Testosterone replacement therapy could help in this case, but it might not be sufficient to achieve hard erections, and it must be combined with other treatment options. Diabetes is a disease which might be linked to ED because it causes damage to the microvasculature of the body as well as the nervous system.
• Neurogenic – caused by aging or neurodegenerative diseases such as Alzheimer’s or Parkinson’s disease. Neurogenic causes refer to damages to the nervous system and can include strokes, injuries to spinal cord, etc. These health problems can severely affect erection quality regardless of age.
• Vasculogenic – affections such as arteriosclerosis, high blood pressure, high triglyceride levels can also cause erectile dysfunction. Men with blood pressure higher than 130/85, a body mass index over 30 as well as triglycerides over 150 mg/dL are at risk of developing ED at some point in the future.
• Psychogenic – this refers to improper stress management, feelings of guilt, shame, depression, anxiety, lack of self-confidence, internal sexual conflict, etc. Men who have very stressful lives are more likely to have weak erections as well as poor libido.

It is worth mentioning that unhealthy habits such as smoking, excessive alcohol consumption, and lack of exercise can drastically increase the likelihood of developing impotence for men of all ages.

Before treating ED, doctors first assess the health of the cardiovascular system (heart, veins, and arteries) to determine if it is healthy enough for proper sexual activity. A high cardiac risk might indicate that the patient needs treatment for a heart condition first, before receiving treatment for erectile dysfunction.

Sexual dysfunction management and treatment options beyond testosterone

Impotence or sexual dysfunction is treated in small steps and it begins by changing lifestyle risk factors such as quitting smoking, lowering alcohol consumption, switching to a healthier diet, engaging in regular physical activities, etc.

PDE-5 inhibitors

The next step is to take advantage of first-line medical therapies such as using phosphodiesterase type 5 inhibitors (PDE5Is). These substances lead to increased smooth muscle tone and should be taken approximately 1 hour before sexual intercourse and up to 12 hours for T a d a l a f i l.

These PDE-5 inhibitors are known to be safe and can be used by men of all ages, except for those who take nitrates on a daily basis. Some people respond better to certain types of inhibitors, so trying more than just a single substance is recommended for achieving the desired results.

Vacuum Erection Device

There are numerous types of vacuum erection devices on the market and most of them generally consist of a cylinder which is placed on the penis and creates an air-tight seal to the body, causing negative pressure and improving blood flow. A constriction band is placed at the base of the penis to maintain an erection and allowing sexual intercourse after the cylinder is removed.

This type of treatment is considered second-line therapy for sexual dysfunction and is a non-invasive way of treating it. Manufacturers create VEDs of various sizes and they ship them with instruction manuals to help patients use the cylinders properly to achieve an erection.

Intraurethral Suppositories

This treatment option consists of inserting small suppositories into the urethra to allow smooth muscle relaxation. The penis is massaged with both hands to allow the corpora cavernosa to absorb the medicine. One of the most common side effects of this treatment option is penile pain, but it can be a practical treatment option for certain people. The first Intraurethral suppository might be administered under medical supervision to prevent unwanted injuries to the shaft.

Intracavernosal Injections

Patients who suffer from erectile dysfunction might also want to try intracavernosal injections which are formulated with a special substance that inhibits vasoconstriction. This allows the patient to achieve a satisfying erection and this method is considered to be one of the safest and most common treatment options for ED.

The first injection is done under medical supervision to avoid damaging important areas of the penis such as the urethra or penile nerves. Once the patients get over the anxiety of having needles into their penis, they can learn how to administer injections on their own.

Bimix, Trimix, and Quadmix injections are good examples of intracavernosal injections for achieving hard erections. They are available by prescription from different pharmacies.

Penile Implant Surgery

The third-line therapy for ED consists of penile implant surgery which means inserting non-inflatable implants into the penis.

There are 2-piece and 3-piece inflatable penile prosthesis which can be inserted into the penis. A small pump is inserted into the scrotum and helps to inflate the implants when an erection is required. Although there is the possibility of developing infections, penile implant surgery is a popular treatment for erectile dysfunction and it can be more cost-effective in the long run.

Conclusion

Although erectile dysfunction is still a taboo subject for some people, this medical condition has been heavily researched, it can be properly diagnosed in a variety of ways, and multiple treatment options have been created to help patients achieve sexual satisfaction. One of the best and easiest ways to diagnose ED is by using blood tests to detect hormone imbalances.

Patients who are not happy with their performance in bed should make the first and most important step and visit a doctor to get more information about ED, getting adequate physical examination as well as treatment. Luckily, medical improvements are made each year and treatment strategies are refined and enhanced, so treating impotence is increasingly safer and easier these days!

DiscountedLabs.com offers affordable blood tests you can order online in the United States without the need of a doctor's visit. We have no hidden fees and have an easy ordering process.

HOW DOES DISCOUNTEDLABS.COM WORK?

1. Go to the "Find a Location" page to find the closest lab location. No need to make an appointment since walk-ins are welcomed. Once you have identified your closest location, go to step 2.
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If you’re a woman who is 35 years old or younger and have been unable to conceive after one year of unprotected intercourse, or after six months if you’re over 35, you and your partner should have a full physical and medical evaluation with a Reproductive Endocrinologist.

Several blood tests are available to determine if you, your partner, or both of you have a problem that is causing infertility.

FSH Testing

Follicle-stimulating hormone (FSH) helps control a woman’s menstrual cycle and the growth of follicles, which contain eggs, in the ovaries. The FSH test is done on the second or third day of your menstrual cycle, and is used to evaluate egg supply and ovarian function.

In men, FSH regulates the production and transportation of sperm. The test is used to determine sperm count.

Estradiol Test (LC/MS)

Estradiol is an important form of estrogen. An estradiol test is used to measure your ovarian function and to evaluate the quality of your eggs. Like FSH, it is done on the second or third day of your menstrual cycle.

Luteinizing Hormone (LH) Level

In women, luteinizing hormone (LH) is linked to ovarian hormone production and egg maturation. A luteinizing hormone test performed at the beginning of your cycle may help diagnosis hormonal imbalances, like PCOS. When LH testing is performed midway through your menstrual cycle (day 14 of a 28-day cycle), the level may assist in determining when you’re ovulating.

In men, LH stimulates the hormone testosterone which affects sperm production. An LH test may be useful in evaluating male-factor infertility.

Anti-Müllerian Hormone (AMH)

AMH has quickly become the ‘gold standard’ in fertility blood tests. Secreted by the small antral follicles in the ovary, AMH is present until a woman reaches menopause. Performing an AMH test gives a physician a good understanding of your ovarian function and egg reserve. Lower AMH levels can predict a lower egg yield and thus, a lower chance of success in patients undergoing IVF.

AMH can be tested at any point in your menstrual cycle, and can also be done if you’re taking oral contraception.

Serum Progesterone (LC/MS)

Progesterone is a female hormone produced by the ovaries during ovulation. It prepares the endometrial lining of the uterus and makes it receptive to fertilized eggs. A serum progesterone test is used to determine if ovulation is occurring.

Since progesterone levels increase towards the end of a woman’s cycle, the test is done during the luteal phase of your menstrual cycle (just before your period starts).

Prolactin

The hormone prolactin is made by the pituitary gland, and causes milk production.

In women, a prolactin test may be performed:

• In the evaluation of infertility.
• To determine why a woman is not ovulating.
• When a woman has symptoms, such as nipple discharge,

Testosterone (LC/MS)

Affecting the sexual functioning of both men and women, testosterone is probably the most well-known androgen.

In women, a testosterone test is used in the evaluation of conditions including polycystic ovarian syndrome (PCOS).

In men, an androgen test is used to find the cause of a low sex drive, the inability to get an erection, or infertility.

Thyroid Stimulating Hormone (TSH)

Thyroid hormones are critical in pregnancy. If the thyroid is over or underactive, this can affect ovulation regulation and reduce fertility. Many women suffer from thyroid dysfunction; around 25% of women in their lifetime, which is around 4x more women than men. Graves disease is the most common thyroid dysfunction, affecting 1% of the population. These conditions are important in fertility, because thyroid hormones are important in regulating ovulation, preventing miscarriage and aiding foetal brain development.

The term fibromyalgia came from the Latin word “fibro” (fibrosis tissue), and the Greek terms for “myo” (muscle) and “algia” (pain).

Fibromyalgia is a relatively common health problem that affects around 3-4% of people worldwide. It consists of consistent pain across the entire body and it's a disease that directly affects the nervous system.

Although the pain symptoms are obvious, it can be really difficult to diagnose this condition. That's because many other illnesses cause pain in various parts of the body. With that being said, a lot of progress has been made when it comes to diagnosing fibromyalgia.

Keep reading to learn more about this health issue, how to test for it, and what are your treatment options.

What Is Fibromyalgia and What Are Its Symptoms?

As mentioned earlier, fibromyalgia creates consistent muscular and joint pain. This type of pain is disturbing, but bearable according to most patients. The muscles of a person with fibromyalgia are sensitive to the touch. This can drastically reduce the quality and enjoyment of life in patients diagnosed with this condition.

Some of the most common symptoms of fibromyalgia include:

• Tenderness and pain on joints, skin, and muscles
• Confusion and lack of concentration
• Sleeping difficulties
• Having troubles remembering things

Most of these secondary symptoms are directly caused by the constant, silent pain that fibromyalgia patients feel every day. It can be really difficult to think, focus, and sleep when your body is aching all the time for no obvious reasons.

It's important to stress out that fibromyalgia causes pain across the entire body. This includes your shoulders, neck, jaw, upper back, lower back, abdomen, chest, legs, and even the fingers of your limbs. The entire nervous system is affected and this is felt in the hundreds of muscles that make up the human body.

How Is Fibromyalgia Diagnosed?

Body pain is usually associated with a host of other health problems, so diagnosing fibromyalgia is not a walk in the park. Doctors usually run a battery of blood tests to rule out other conditions. Here are a few tests used to diagnose fibromyalgia.

Complete Blood Count

This test group looks at specific variables in your blood such as red blood cells, white blood cells, platelets, and more. This helps discover anemia or any infections that might cause you constant, whole-body pain.

Thyroid-Stimulating Hormone (TSH)

TSH is a hormone produced by your pituitary. It tells your thyroid gland what hormones to secrete and in what quantity. Your thyroid gland is responsible for numerous metabolic processes. Damages to your thyroid can cause symptoms similar to fibromyalgia such as frequent pain throughout your entire body, fatigue, and so on.

Complete Metabolic Panel

The CMP checks the function of your liver, kidneys, and several other organs. It can detect any electrolyte imbalance, diabetes, and other types of health problems that might cause you symptoms similar to fibromyalgia.

Iron Blood Test

Iron is one of the most important minerals in your body. Too little iron can cause anemia which is characterized by fatigue, lack of sleep, and minor muscle aches. At the same time, too much iron is also a bad thing, so this test will give you an accurate result when it comes to blood iron levels in your body.

Vitamin B12

The vitamin B complex is essential for a healthy nervous system, particularly vitamin B12. Low levels of this vitamin are commonly associated with fatigue, diffuse pain, and lethargy. Vitamin B12 depletion can be caused by various things including consuming too much alcohol and not eating a balanced diet.

Vitamin D

At the same time, too little vitamin D can also cause problems in your body including tiredness, mild pain, and a general state of confusion. Vitamin D is metabolized from the sun, but most people don't get enough sun exposure to get enough vitamin D in their system.

This test will reveal how much vitamin D is in your bloodstream. If you're deficient in this vital nutrient, you might be able to easily correct this problem with regular vitamin D supplementation.

Creatine Phosphokinase (CPK Test)

CPK is an enzyme found in most muscles in your body. When the muscles are injured, CPK is released into the bloodstream. This test can detect excess CPK in your system and it will help doctors detect infections and diseases quickly.

CPK is also split into 3 categories and each corresponds to certain muscle groups and organs. Measuring your levels of CPK can indicate recent muscle damage, heart attacks, brain problems, and more.

Erythrocyte Sedimentation Rate (ESR Test)

ESR is often recommended as a routine laboratory test in fibromyalgia patients to rule out the presence of inflammatory disorders that may mimic symptoms. The upper limit of normal for the ESR in women is half their age (eg, a level of 40 in an 80-year-old women is normal), and in men is half their age minus 10.

How Is Fibromyalgia Treated?

Once a fibromyalgia diagnosis is confirmed, your doctor will help you fight this disease in a number of ways. Usually, a combination of medications and therapies is used, depending on the severity of your pain and how much disturbance it causes in your life.

Some of the drugs used to treat fibromyalgia include pain relievers such as ibuprofen, naproxen sodium, and others. These will help you cope with the constant pain easier. Other drugs used are anti-depressants such as Duloxetine.

These drugs might help fight the pain and lethargy commonly associated with fibromyalgia. Finally, anti-seizure drugs might be useful in extreme cases.

On top of that, counseling is highly recommended to find ways to cope with the constant pain and alleviate it slightly. Physical therapy is also very useful in improving the flexibility and stamina of people who struggle with fibromyalgia.

Other types of self-care strategies include practicing yoga, meditating, taking long, hot baths, or engaging in vigorous cardio exercise. These activities release natural endorphins that help numb the pain of people with fibromyalgia.

Order Your Fibromyalgia Panel Today!

As you can see, the only reliable way to test for fibromyalgia is by ordering a comprehensive panel of blood tests. This will help doctors rule out other conditions and accurately formulate treatment options for your specific case.

Order your fibromyalgia panel from Discountedlabs.com today and take advantage of quick delivery of results as well as one of the lowest prices for blood tests in the US!

This panel includes hormones that have been implicated in gynecomastia by several studies. Gynecomastia is a benign enlargement of the male breast resulting from a growth of the glandular tissue of the breast. It is defined clinically by the presence of a rubbery or firm mass extending concentrically from the nipples. At least 30% of males will be affected during their life. Since it causes anxiety, psychosocial discomfort and fear of breast cancer, early diagnostic evaluation is important, and patients usually seek medical attention. Causes include hormone imbalance and genetic predisposition.

Tests Include:

TESTOSTERONE, Free and Total, LC/MS Assay (T > 1,500 ng/dL)

DHT ( Dihydrotestosterone)

Low blood levels of testosterone and DHT in the presence of high estradiol, IGF-1, thyroid hormones or prolactin may accelerate the growth of breast tissue in men

ULTRA SENSITIVE ESTRADIOL

IGF-1 (Insulin Growth Factor 1)

PROLACTIN

TSH (Thyroid Stimulating Hormone)

FREE T3 (Free Triiodothyronine )

What is Gynecomastia and How to Diagnose it

According to the National Institute of Health, gynecomastia can affect more than 50% of adolescent boys during puberty.

At the same time, gynecomastia can also affect up to 65% of men between 27 and 92 years, depending on their lifestyle, habits, drug intake, and other factors.

But what is gynecomastia and why so many men get it? Is it dangerous? And what can you do to treat it effectively and safely?

Keep reading this article to find out everything you need to know about gynecomastia, its types, causes, and treatment options.

Gynecomastia is a benign enlargement of the male breast resulting from a growth of the glandular tissue of the breast. It is defined clinically by the presence of a rubbery or firm mass extending concentrically from the nipples. At least 30% of males will be affected during their life. Since it causes anxiety, psychosocial discomfort and fear of breast cancer, early diagnostic evaluation is important, and patients usually seek medical attention.

Evaluation of gynecomastia must include a detailed medical history, clinical examination, specific blood tests, imaging, and tissue sampling. Individual treatment requirements can range from simple reassurance to medical treatment or even surgery.

Gynecomastia Symptoms

Men who start experiencing this problem complain of pain and tenderness around the nipple area. Gynecomastia was reported to cause an imbalance between estrogen and androgen action or an increased estrogen to androgen ratio, due to increased estrogen production, decreased androgen production or both. Androgens include testosterone and DHT. High estradiol in the presence of low testosterone and DHT, growth hormone (IGF-1 is a metabolite), and a genetic predisposition to gynecomastia can increase the size of breast tissue in men.

Potential Causes of Gynecomastia

Physiological gynecomastia is common in pubertal boys and appears to be associated with increased levels of insulin-like growth factor-1 (IGF-1) and pubertal growth, but not with a shift in the balance between estrogen and testosterone, a new study suggests. Study authors noted that IGF-1 together with estrogen is essential for the growth of breast tissue, and it appears that the effect of growth hormone on breast growth is mediated through IGF-1. "The stimulatory effect of IGF-1 on breast formation was synergized by estradiol, which was also elevated in boys with gynecomastia in our study. However, serum testosterone was similarly elevated, leaving the estradiol/testosterone ratio unaltered."

Testosterone converts into estradiol, DHT, and other metabolites. Men with higher amounts of the enzyme aromatase usually have this problem even at lower doses of testosterone. The growth of this glandular tissue is also influenced by a higher fat percentage, older age, excessive alcohol intake, and the use of certain medications. Gynecomastia rarely occurs in men using testosterone replacement since testosterone to estradiol ratios are improved.

In several studies on testosterone replacement, only a very small percentage of people receiving testosterone experience growth of breast tissue. In one HIV-specific study conducted by Dr. Judith Rabkin in New York, she reported that out of 150 men enrolled in the study, two men experienced this adverse reaction.

Dihydrotestosterone (DHT) is a natural metabolite of testosterone that has antiestrogen activity and cannot be converted into estradiol at the tissue level. Systemic or locally administered DHT has been successfully prescribed for the treatment of patients with idiopathic and estrogen-induced gynecomastia.

Gynecomastia is also seen in men with androgen resistance with low testosterone and DHT, where unfettered estrogen can stimulate subsequent breast development. However, in men with normal androgen receptor activity, estradiol is unable to stimulate breast development. This is thought to be due to an imbalance between the inhibitory and stimulatory effect of these hormones.

Medications and Products That Can Cause Gynecomastia

Some medications have been reported in the medical literature to cause gynecomastia due to decreases in testosterone, increases in estradiol, or both. These include:

· Antiandrogens. 

· HIV medications. 

· Anti-anxiety medications.

. Finasteride

· Tricyclic antidepressants. 

· Glucocorticoid steroids.

· Antibiotics.

· Ulcer medication such as cimetidine .

· Cancer treatment (chemotherapy).

· Heart medications such as digitalis and calcium channel blockers.

· Anabolic steroids

· Soy and flaxseed

· Exposure to pesticides and byproducts of plastic processing has also been linked to increased estrogen and decreased sperm count in men.

If the gynecomastia is drug-induced, decreased tenderness and softening of the glandular tissue will usually be apparent within one month after discontinuation of the drug. However, if the gynecomastia has been present for more than one year, it is unlikely to regress substantially, either spontaneously or with medical therapy, because of the presence of fibrosis. In such circumstances, surgical subcutaneous mastectomy, ultrasound-assisted liposuction, and suction-assisted lipectomy are the best options for cosmetic improvement, as described in several case series.

During the rapid, proliferative phase, manifested clinically as breast pain and tenderness, medical therapy may be attempted. Most studies of drugs -- including testosterone (in patients without hypogonadism), have been uncontrolled and thus difficult to interpret because gynecomastia may resolve spontaneously. The few randomized, double-blind, placebo-controlled trials generally have been limited by small samples.

How do you manage gynecomastia if it does occur?

Although not approved for the treatment of gynecomastia, the selective estrogen-receptor modulator tamoxifen, administered orally at a dose of 20 mg daily for up to 3 months, has been shown to be effective in randomized and nonrandomized trials, resulting in partial regression of gynecomastia in approximately 80% of patients and complete regression in about 60%. Patients in whom tamoxifen is effective usually experience a decrease in pain and tenderness within one month. In a retrospective analysis of a series of patients with idiopathic gynecomastia, 78% of patients treated with tamoxifen had complete resolution of gynecomastia, as compared with only 40% of patients receiving danazol. In case series describing the use of tamoxifen for this condition in more than 225 patients, adverse events were uncommon but can include body aches, low sex drive, and fatigue.

The aromatase inhibitor anastrozole was not shown to be more effective than placebo in a randomized, double-blind, placebo-controlled trial in boys with pubertal gynecomastia. Although in an uncontrolled study of 10 patients with pubertal gynecomastia, the selective estrogen-receptor modulator raloxifene was shown to result in more than a 50% decrease in the size of the gynecomastia in the majority of the boys, there are insufficient data to recommend its use at this time.

Lowering the testosterone dose had not proven helpful for the two patients in Dr. Rabkin's study. The use of antiestrogens, such as tamoxifen 10 mg twice daily, with lower doses of testosterone have been effective. Some physicians prescribe low dose aromatase inhibitors for men with early-onset gynecomastia. Gynecomastia can become permanent if the condition lasts very long although it may reduce in size when the androgen use is discontinued. In the absence of resolution, surgical correction may be necessary in severe cases.

For men who experience enlarged breast size, doctors usually check estradiol levels to determine whether too much testosterone is being converted into estrogen. However, physicians usually forget that other hormone metabolites like DHT and IGF-1 may be involved in the development of gynecomastia, so they do not include these tests in the diagnostics panel.

Warning: Bringing estrogen down to very low levels could cause health problems in men in the long run. Hair/skin quality and health, brain function, bone density, lipids, sexual function, and other important factors may be greatly influenced by estrogen.

More information about estradiol and gynecomastia.

Bibliography:

Braunstein, G. D., M.D. (2007). Gynecomastia. The New England Journal of Medicine, 357(12), 1229-1237.

Schulster M, Bernie AM, Ramasamy R. The role of estradiol in male reproductive function. Asian J Androl 2016;18:435-40

Gynecomastia FAQ

Here are a few answers to some of the questions you might have about gynecomastia.

1. Is Gynecomastia Painful?

Some patients might experience mild pain in their chest area as well as tenderness, especially when gynecomastia gets into an advanced state. However, the pain is not sharp or intense, and it usually goes away once proper treatment for gynecomastia is administered.

2. Does the Breast Tissue Subside Once Gynecomastia Is Treated?

One of the main concerns of patients with gynecomastia is whether the breast tissue will continue to "hang" after the condition is treated. Unfortunately, the tissue will not subside on its own in most cases, but there are solutions to this problem. Once the underlying cause of gynecomastia is treated, patients can perform small surgeries to remove the excess breast tissue and achieve a more "manly" chest.

3. Does Scarring Occur After Removing the Breast Tissue?

Luckily, the scarring is minimal around the nipple area and almost invisible. Patients can go to the beach and not worry that someone will see that they had gynecomastia surgery because the scarring is virtually non-existent.

4. Are There Any Other Drugs or Substances Which Cause Gynecomastia?

Certain drugs or substances might cause gynecomastia such as marijuana, steroids, or other performance-enhancing drugs. However, men might develop breast tissue enlargement as a result of consuming high amounts of alcohol too. Alcohol can damage the liver, which in turn decreases the production of testosterone.

At the same time, certain drugs such as spironolactone, ketoconazole, and others can also trigger the development of gynecomastia. Cimetidine, which is a drug used to treat ulcer, is also associated with this type of health issue.

Conclusions

Treating gynecomastia can be done with relative ease these days, as long as you are aware of its existence. For a complete and thorough test which helps you diagnose this condition quickly, check out the Gynecomastia Test Panel. This lab test panel provided by Discounted Labs can be done using a blood sample, and you get the results in just a few business days. The results can help your doctor decide what therapies are best for you to eliminate your gynecomastia.

Reference:

Sansone A, et al. Gynecomastia and hormones. Endocrine. DOI 10.1007/s12020-016-0975-9

FREE BONUS: EBook: Beyond Testosterone

Suggested Reading: Testosterone Replacement Blood Test Targets

This lab test panel includes main blood test makers involved in hair loss. Note: Some medications (listed below) may cause hair loss in men and women.

Anemia-related factors:

• Complete Blood Count (CBC)- Can detect potential low hemoglobin and infections that can lead to hair loss. Additionally, some CBC makers like MCV and MCH can detect B-12 and folate deficiency that affects hair growth.
• Ferritin- Low ferritin, an iron storage protein, has been linked to hair loss and slow down of hair growth.
• Iron and Total Iron Capacity (TIBC)- Low iron anemia has been linked to hair los

Hyperandrogenism: Excessive male hormones (androgens):

In healthy women, the ovaries and adrenal glands produce about 40% to 50% of the body's testosterone. Tumors of the ovaries and polycystic ovary syndrome (PCOS) can both cause too much androgen production. High testosterone can lead to high dihydrotesterone (DHT), known factor in male and female hair loss. Cushing disease is a problem with the pituitary gland that leads to excess amounts of corticosteroids and DHEA. In men with genetoc predisposition to hair loss, excess DHT may worsen this issue.

• Total Testosterone Test (LC/MS)
• Free Testosterone (Equilibrium Ultrafiltration)
• DHEA-S
• Dihydrotestosterone (DHT)

Hypothyroidism and Hyperthyroidism: Both low and high thyroid function are known factors in hair loss.

• Thyroid Stimulation Hormone (TSH)
• Free Triidothyronine (Free T3)

Some vitamin defficiencies can also cause hair loss in men and women with poor dietary habits, malabsortion, and illness.  Please check our discounted vitamin tests. 

Causes of Hair Loss

There are many causes of hair loss. Causes include certain diseases, chemical exposure, or drug use. The most common causes are:

• Androgenic Alopecia (AGA) - Male and Female Pattern Baldness, also known as “Androgenic Alopecia”, is the most common cause of hair loss and will affect up to 70% of men and 40% of women at some point in their lifetime. Men typically present with hairline recession at the temples and hair-loss on the upper surface of the head, also known as vertex balding. Women typically present diffuse, or scattered, thinning of the hair over the top of their scalps. People who suffer from this type of hair-loss have an underlying sensitivity to “hair follicle miniaturization” due to androgenic hormones. 
• Poor Nutrition - Usually complete baldness is not seen in people with nutritional deficiencies, thinning of the hair is more common. Studies show that limited food intake and deficiencies in certain nutrients can cause thinning. These include deficiencies of biotin, amino-acids (protein), zinc, and iron. Consuming a diet high in animal fat, such in fast food, can also have a negative effect on hair loss.
• Stress - Stress has been shown to restrict the blood supply to capillaries which prevents oxygen and nutrients from reaching the hair follicle which can prevent hair growth. This effect is similar to having poor circulation.
• Medications - Some medications can cause hair loss, especially medications which affect hormone levels. These medications include contraceptive pills, some forms of hormone replacement therapy, anabolic steroids, and acne medication. Other medications which can have an effect on hair loss include those for blood pressure, diabetes, heart disease, and cholesterol.

What is Hair Loss (alopecia) from Medications?

Alopecia from drugs is a usually reversible nonscarring diffuse hair loss that occurs within days to weeks of starting a new medication or changing the dose.

Who Gets Drug-induced Alopecia?

The development of hair loss and severity depend both on the drug and individual predisposition. Some drugs cause hair loss in most patients receiving an appropriate dose. Other drugs are only occasionally responsible for hair loss.

What Types of Hair Loss Caused by Medications Are There?

There are two types of drug-induced hair loss:

Anagen effluvium – the shedding of actively growing hairs. Anagen effluvium is usually due to chemotherapy drugs and rarely with gold, colchicine or poisoning with arsenic, bismuth, thallium, or boric acid.

Telogen effluvium – the shedding of resting, or bulb hairs. Telogen effluvium is the mechanism of virtually all other medication-induced hair loss. The list of possible drug causes is very long and includes:

• Anti-coagulants
• Anti-hypertensives
• Hormones — oral contraceptive pill (during/after/changing), hormone replacement therapy, androgens.
• Anticonvulsants
• Mood stabilizers and antidepressants — most, such as lithium 12–19%
• Others — some antipsychotics and anti-anxiety drugs

What are the Treatments for Hair Loss?

Several treatments are currently being used for hair loss as prescribed medications or over the counter (OTC) options.

Rogaine (Minoxidil)

Unlike Propecia, Rogaine doesn't come with all the negative side effects. This OTC treatment is a topical one rather than oral, so it is applied directly to the scalp as a means of combatting hair loss.

How does it work? Rogaine helps to increase the flow of blood to your scalp and hair follicles, preventing the follicles from shrinking--basically jump-starting them and getting them back into working order. The topical treatment is very unlikely to interact negatively with oral medications, so it should be fairly safe for your use.

Low dose oral minoxidil is showing some promise in growing hair in men and women.

Platelet-Rich Fibrin Matrix Injections

In 2014, a study was published in the journal Facial Plastic Surgery, detailing the results of using platelet-rich fibrin matrix as a means of treating hair loss.

Platelet-rich fibrin matrix (PFRM) is a mixture made by separating the red and white blood cells from the platelets and plasma. According to the Journal of the American Medical Association, " It is collected in a vacuum-sealed collection tube with a thixotropic separator gel, and the tube is centrifuged for 6 minutes at 1100 rpm. This process separates the red and white blood cells from the plasma and platelets, which are then transferred in a closed system to a second tube containing calcium chloride; it is this small amount of calcium that initiates the fibrinogen cleavage and the fibrin polymerization."

In the Facial Plastic Surgery study, 15 men and women with androgenetic alopecia were given injections of PFRM three times a month over the course of 1 year. During that time, their hair density indexes were monitored. After just 1 year, hair density indices increased significantly, meaning the patients' hair grew thicker and denser on the scalp.

Latanoprost

Latanoprost is a medication used to help regrow eyelashes that have fallen out as a result of thyroid disorders or stress. However, studies have shown that the hair re-growth benefits extend beyond just the eyelashes, but the medication can even help to replenish hair that has been lost from the head.

A 2012 study published in the Journal of the American Academy of Dermatology found that latanoprost "significantly increased hair density (terminal and vellus hairs) at 24 weeks". Essentially, it could help to stimulate activity in the hair follicles, making it a potentially effective treatment for hair loss.

Ketoconazole

Ketoconazole (KCZ), originally used for seborrheic dermatitis, dandruff (in Nizoral shampoo) and as an anti-fungal medication, has also been found to be effective in stimulating new hair growth when applied topically.  Even though the exact mechanism of topical KCZ for hair growth is not clearly understood, evidence suggests that ketoconazole acts as an androgen receptor suppressor.

Progesterone

Progesterone is a critical hormone produced by the female body. Progesterone acts as a precursor in the production of other vital hormones, such as estrogen and cortisone.

Topical progesterone-based hair restoration therapy is demonstrably effective in treating hair loss according to multiple studies. It's believed that progesterone acts by inhibiting an enzyme called 5-alpha reductase, the enzyme needed to convert testosterone into DHT. Specifically, progesterone will prevent DHT from forming in the first place by blocking the action of 5-alpha reductase).

Certain other studies have also suggested that progesterone could have a significant effect on human hair growth beyond its ability to prevent testosterone from converting into DHT.

Higher levels of estrogens during pregnancy are thought to be the reason for an increase in the ratio of hair follicles in the growing phase of the female hair growth cycle. It's also true that after giving birth (when progesterone levels decrease), these new follicles enter a resting phase that results in increased hair shedding and temporary hair thinning.

Spironolactone

Spironolactone is a powerful androgen receptor blocker, and when applied topically can prevent DHT from attaching to both hair follicles and oil glands.

Spironolactone can effectively prevent DHT from binding to androgen receptors in your follicles and stimulating your body's immune response to attack your own hair. Although the reason for this isn't clearly understood, topical spironolactone is a scientifically verified way to stop DHT from causing a follicle destroying immune response.

Topical Combination Hair Loss Products

Compounding pharmacies make topical scalp solutions to treat hair loss containing a combination of several of the options mentioned above.

Heart Test Panel: A Comprehensive Analysis of Cardiovascular Risks

Our Heart Test Panel at DiscountedLabs.com offers an extensive series of blood tests essential for assessing cardiovascular risks. This in-depth examination covers critical factors related to heart health and overall well-being. Here's a detailed breakdown of the various tests included in this panel:

1. Comprehensive Metabolic Panel (CMP)

• Overview: The CMP consists of 14 blood tests serving as an initial medical screening tool to review overall health.
• Components: The CMP checks kidney function, liver function, electrolyte and fluid balance.
• Special Note: Specific electrolytes like potassium play a crucial role in heart health.
• Fasting Required: Yes.

2. Complete Blood Count (CBC) with Differential

• Overview: CBC measures various components of blood, including:
  • Red blood cells (carry oxygen)
  • White blood cells (fight infection)
  • Hemoglobin (oxygen-carrying protein in red blood cells)
  • Hematocrit (proportion of red blood cells to fluid component)
  • Platelets (assist with blood clotting)
• Significance: Hematocrit's correlation with blood thickness can be essential for cardiovascular assessments.

3. High Sensitivity C-Reactive Protein (hs-CRP)

• Overview: hs-CRP level above 2 mg/L, coupled with other risk factors, requires retesting to rule out acute inflammatory responses. A level >10 mg/L might indicate high cardiovascular risk.
• Importance: Helps in reclassifying cardiovascular risk, suggesting possible treatments, including lifestyle changes.

4. Cardio IQ® Advanced Lipid Panel

• Overview: This report provides a thorough assessment of cardiovascular risks, helping physicians tailor the best individualized treatment.
• Components: Includes Total Cholesterol, Triglycerides, HDL, LDL, Cholesterol/HDL ratio, LDL Particle Number, LDL Peak Size, LDL Pattern, HDL Large, LDL Small, LDL Medium, Apolipoprotein B, Lipoprotein (a).
• Visual Representation: The report is color-coded with “optimal,” “moderate,” and “high-risk” categories, offering a comprehensive yet simple understanding.
• Fasting Required: Yes.
• Results Time: Approximately 2 weeks.

5. Homocysteine

• Overview: Measures a chemical produced when the amino acid methionine breaks down.
• Importance: Elevated homocysteine levels indicate increased risks for arterial hardening, heart attack, stroke, and venous thrombosis.

6. D-Dimer

• Overview: D-Dimer measures fibrinolytic activation and intravascular thrombosis, a crucial indicator in the blood.
• Significance: Particularly valuable for ruling out venous thromboembolism in high-risk individuals.

Conclusion

The Heart Test Panel is a robust set of diagnostics targeting a comprehensive understanding of cardiovascular health. By offering insights into areas such as metabolism, blood components, inflammation markers, lipid profile, amino acid breakdown, and blood clot factors, this panel empowers both physicians and patients to make informed decisions about heart care and disease prevention.

At DiscountedLabs.com, we prioritize accuracy and accessibility in cardiovascular testing. Entrust your heart health to our advanced screening methods and detailed reports. Book your Heart Test Panel today to embark on a journey toward optimal cardiovascular well-being.

This panel measures the blood levels of arsenic, lead, and mercury.

The patient should avoid seafood and red wine 72 hours before collection.

Heavy Metals Test Profile , Blood: Arsenic, Lead and Mercury

Heavy metal toxicity is a growing concern in today's world. Heavy metals such as arsenic, lead, and mercury can accumulate in the body over time and cause serious health problems. A heavy metals test profile measures the amount of these toxic substances in your blood, providing you with important information about your overall health. In this blog post, we will discuss the importance of a heavy metals test profile and how it can help you identify potential health risks. We will cover everything from how these heavy metals are ingested to what symptoms you should look out for. You will also learn about the procedure for collecting and testing blood samples for heavy metals, how to prepare for the test, and how to interpret your results. Finally, we will discuss treatment options and how you can purchase an affordable heavy metals test profile without visiting a doctor on DiscountedLabs.com.

The Importance of Heavy Metals Test Profile

Determining heavy metal toxicity in the body is crucial, and a comprehensive blood test can help achieve this. By identifying potential sources of heavy metal exposure, interventions can be targeted to minimize risk. Assessing the impact of heavy metal poisoning on overall health allows for early detection and prevention of related conditions. Additionally, clinicians can develop personalized treatment plans for heavy metal detoxification based on the test results. This comprehensive profile plays a vital role in maintaining public health by confirming contamination and ensuring prompt intervention.

Understanding the Role of Arsenic, Lead and Mercury in the Body

Arsenic, lead, and mercury play significant roles in the body, but they can also have detrimental effects when present in high levels. Arsenic is linked to cardiovascular diseases and an increased risk of cancer. Lead impairs neurological development, particularly in children. Mercury affects the nervous system and can lead to cognitive and behavioral issues. Each heavy metal has its own specific health implications and toxic effects. Understanding the role of each heavy metal is crucial for targeted treatment and prevention strategies. By identifying their presence and levels, healthcare professionals can develop personalized plans to address heavy metal toxicity.

How are Heavy Metals Ingested?

Heavy metals can be ingested through various means. Drinking water contaminated with heavy metals is a common source of exposure. Seafood consumption, especially fish and shellfish, can lead to the accumulation of mercury in the body. Occupational exposure in certain industries can occur through inhalation or skin contact. Ingesting lead particles from deteriorating paint, particularly lead-based paint, is another way heavy metals are ingested. Additionally, exposure to heavy metals can happen through common household products.

Common Sources of Arsenic, Lead, and Mercury

Arsenic can be found in pesticides, herbicides, and various industrial processes. Lead is often present in old pipes, lead-based paint, and certain occupations. Mercury can be found in thermometers, dental fillings, and contaminated seafood. Identifying these potential sources is crucial in reducing exposure and preventing heavy metal poisoning. Being aware of common sources of heavy metal poisoning allows individuals to take proactive measures to minimize the risk of exposure. By understanding where these heavy metals come from, people can make informed decisions about their environment and overall health.

What are the Symptoms of Heavy Metal Poisoning?

Symptoms of heavy metal poisoning include gastrointestinal issues like nausea, vomiting, and abdominal pain. Neurological symptoms may manifest as headaches, memory loss, and peripheral neuropathy. Cardiovascular problems such as high blood pressure and shortness of breath can also occur. Anemia, resulting in fatigue and reduced red blood cell production, is another common symptom. Recognizing these signs helps with early detection and prompt treatment.

Recognizing Signs of Arsenic, Lead, and Mercury Poisoning

Recognizing the signs of heavy metal poisoning is crucial for prompt diagnosis and treatment. Arsenic poisoning can manifest as skin changes, cardiovascular diseases, and gastrointestinal issues. Lead poisoning may result in developmental delays, behavioral changes, and anemia. Mercury poisoning can lead to neurological problems, tremors, and kidney damage. Each type of heavy metal poisoning exhibits distinct signs, aiding in accurate identification and targeted intervention. Early recognition of symptoms is essential for minimizing long-term health complications.

What Does a Heavy Metal Blood Test Involve?

A heavy metal blood test involves a simple venous blood draw for laboratory analysis. The collected blood specimen is processed through centrifugation to separate serum or plasma for testing. The test measures levels of arsenic, lead, and mercury in the blood, providing a comprehensive assessment of heavy metal exposure. Results are typically available within a few days.

Procedure for Blood Collection and Testing

To ensure an accurate assessment of heavy metal exposure, the procedure for blood collection and testing involves various steps. A trained professional, known as a phlebotomist, collects blood from a vein using a sterile needle in a process called phlebotomy. The collected specimen is then labeled properly and transported to the laboratory for analysis. Specialized equipment is used to measure heavy metal levels accurately in the blood sample. The results obtained are compared with established guidelines, known as the reference range, to determine if heavy metal exposure is within normal limits. Blood testing plays a crucial role in ensuring an accurate assessment of heavy metal exposure, helping individuals identify and address potential health risks associated with heavy metal contamination.

How to Prepare for a Heavy Metal Blood Test

To prepare for a heavy metal blood test, there are several important steps to keep in mind. Due to the potential impact of food intake on some heavy metals, fasting may be necessary first. It's also crucial to discuss any medications you're taking with your healthcare provider, as some medications can interfere with the test. Minimizing potential exposure to heavy metals prior to the test is important, such as avoiding contact with insecticides or ceramics. Lastly, be sure to follow any pre-test instructions provided by your healthcare provider, as adequate preparation ensures reliable and meaningful test results.

Pre-Test Instructions and Considerations

To ensure accurate results for certain heavy metals, it is important to follow specific fasting instructions. Additionally, inform your healthcare provider about all medications, including supplements, that you are taking, as they can interfere with the test. It is crucial to share any relevant symptoms or exposure history for a comprehensive assessment. Don't hesitate to discuss any concerns or questions with your healthcare provider before the test. Proper pre-test preparation is essential to obtaining reliable and meaningful results for your heavy metal blood test.

Risks Associated with the Heavy Metal Blood Test

The heavy metal blood test is a valuable tool for measuring levels of metals such as arsenic, lead, and mercury in the body. This test involves taking a blood sample, typically from a vein, to identify potential heavy metal exposure. While the test itself is generally safe, there are some possible risks to be aware of. These can include bruising or bleeding at the site where the blood is drawn. To minimize these risks and ensure accurate results, it is important to follow any preparation instructions provided by the testing facility.

Interpreting the Results of the Heavy Metal Blood Test

Results from the heavy metal blood test are typically reported in micrograms per deciliter (µg/dL). Elevated levels may indicate heavy metal poisoning or exposure. It's important to note that reference ranges can vary depending on the specific metal being tested. To accurately interpret these results, it is recommended to consult a healthcare provider. In some cases, further testing may be necessary to obtain a definitive diagnosis.

What if Your Test Shows High Levels of Heavy Metals?

If your test shows elevated levels of heavy metals, further evaluation may be necessary. A healthcare provider can assess your symptoms and medical history to determine the appropriate course of action. Treatment options may include chelation therapy to remove excess metals from the body and lifestyle changes to reduce exposure. Regular monitoring of blood levels may be recommended as well.

Can Heavy Metal Poisoning be Treated?

Treatment options for heavy metal poisoning vary depending on the specific metal involved. Chelation therapy is commonly used for certain heavy metals. Early detection and removal of the source of exposure are crucial, and personalized treatment recommendations should be sought from a healthcare provider. Follow-up testing may be necessary to monitor progress.

How to Buy an Affordable Heavy Metals Test Profile Without a Doctor's Visit on DiscountedLabs.com?

Looking to buy an affordable heavy metals test profile without a doctor's visit? Visit DiscountedLabs.com.

Conclusion

In conclusion, getting a Heavy Metals Test Profile is essential for identifying and addressing potential heavy metal poisoning in the body. Arsenic, lead, and mercury are common heavy metals that can have harmful effects on our health. It is important to understand the sources and symptoms of heavy metal poisoning in order to take the necessary precautions. The Heavy Metals Blood Test involves a simple procedure of blood collection and testing. Interpreting the results of the test is crucial, and if high levels of heavy metals are detected, further treatment may be necessary. To make the process more convenient and affordable, you can purchase a Heavy Metals Test Profile without visiting a doctor through DiscountedLabs.com. Take charge of your health and ensure the well-being of your body by being proactive about heavy metal testing.

Your liver plays a crucial role in maintaining your overall health and well-being. Understanding the function of your liver is essential for diagnosing and monitoring various medical conditions. In this comprehensive guide, we will delve into the world of Hepatic Function Panels, exploring their significance and key components. We will discuss the importance of liver health and how these panels help identify liver injuries and diseases. Additionally, we will decode the results of these tests, shedding light on what high or low levels indicate. You'll also find valuable information on how to prepare for the test and factors that may interfere with accurate results. Whether you're a healthcare professional or an individual looking to take control of your health, this guide will equip you with the knowledge you need to understand Hepatic Function Panels. Plus, we'll even show you how to buy an affordable panel on DiscountedLabs.com!

An Overview of Hepatic Function Panel

A hepatic function panel is a blood test that measures the levels of various liver enzymes and proteins to assess the health and function of the liver. This panel typically includes tests for alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), total bilirubin, albumin, and total protein. Abnormal results on a hepatic function panel can indicate liver disease or dysfunction, such as hepatitis, liver damage, or cirrhosis. It is commonly ordered to monitor liver health, assess medication side effects, or investigate symptoms like jaundice or vomiting. Interpreting the results requires understanding the normal range and considering additional tests if necessary. Making lifestyle changes and interventions can help improve liver function.

The Importance of Liver Health

The liver, an essential organ in our body, plays a crucial role in detoxification, metabolism, and nutrient storage. Maintaining a healthy liver is vital for overall well-being and disease prevention. Various factors, such as diet, alcohol consumption, and medication use can influence liver health. Regular monitoring of liver function through a Hepatic Function Panel can help detect early signs of liver damage or disease. It is important to take proactive steps to support liver health, such as maintaining a balanced diet and avoiding excessive alcohol intake. Prioritizing liver health ensures the proper functioning of this vital organ.

Key Components of Hepatic Function Panel

Liver enzymes like AST, ALT, and ALP levels are essential for assessing liver damage or disease. Elevated bilirubin levels may indicate liver dysfunction or blockage, while decreased albumin levels can point towards liver damage or disease. The total protein component of a hepatic function panel helps evaluate liver dysfunction and other health conditions. PT/INR measures blood clotting ability and liver function, while elevated GGT levels can indicate liver damage or disease. These key components of a hepatic function panel provide valuable insights into the health of your liver.

Understanding Total Protein in the Blood

Total protein in the blood is a crucial measurement used to assess liver and kidney function, including liver chemistries. It provides valuable insights into the health of these organs. Low levels of total protein can indicate liver damage or malnutrition, while high levels may be a sign of dehydration or certain medical conditions. Monitoring total protein levels is essential for diagnosing and managing liver disease effectively. Typically, total protein levels are measured alongside other liver function tests to obtain a comprehensive evaluation of liver health. By analyzing total protein levels, healthcare professionals can gain valuable information about an individual's liver function and overall well-being.

Albumin: Role and Relevance

The liver produces albumin, a protein that is essential for maintaining the body's proper fluid balance. It serves as a vital component of the hepatic function panel, helping to evaluate liver function and overall health status. Monitoring albumin levels is particularly important, as low levels may indicate liver damage or disease, such as cirrhosis or hepatitis. Various factors, including malnutrition, kidney disease, and certain medications, can affect albumin levels. By assessing albumin levels, healthcare professionals gain valuable insights into the health of the liver and can take appropriate measures for detection and management of liver diseases.

Bilirubin and its Significance

Bilirubin, a yellow pigment formed from the breakdown of red blood cells, plays a crucial role in liver function. Elevated bilirubin levels can indicate liver disease or dysfunction, making it an important marker for diagnosis and monitoring, such as through a bilirubin test. A comprehensive hepatic function panel includes measurements of both direct and indirect bilirubin to provide a complete picture. Monitoring bilirubin levels can help assess the effectiveness of treatment for various liver conditions, such as jaundice and liver damage. By tracking bilirubin levels, healthcare professionals can better understand the health of the liver and make informed decisions for patient care.

AST, ALT, ALP, and GGT: Vital Enzymes for Liver Function

AST, ALT, ALP, and GGT are vital enzymes used to assess liver health and diagnose liver diseases. AST, or aspartate aminotransferase, measures liver cell damage, while ALT, or alanine aminotransferase, indicates liver damage or disease. ALP, or alkaline phosphatase, evaluates liver and bone health, detecting related conditions. GGT, or gamma-glutamyl transferase, helps assess liver function, and diagnose liver diseases and alcohol abuse. Monitoring these enzymes through a Hepatic Function Panel aids in evaluating liver health and diagnosing liver disorders. By analyzing the levels of AST, ALT, ALP, and GGT, healthcare providers can gain valuable insights into the overall health of your liver.

When is a Hepatic Function Panel Required?

A Hepatic Function Panel is required when there are signs or symptoms of liver disease, as part of routine check-ups, or if there are risk factors. It helps assess liver function, diagnose diseases, monitor treatment effectiveness, and determine overall liver health. Healthcare providers make decisions based on medical history and symptoms.

Identifying Liver Injury and Disease

The Hepatic Function Panel plays a crucial role in identifying liver injury and disease, including liver tests. This panel serves as a comprehensive assessment of liver function, enabling the detection of any damage or dysfunction. It is commonly ordered when patients present symptoms of liver dysfunction or as part of a routine check-up. The panel includes tests for liver enzymes, bilirubin levels, and liver function markers. Abnormal results from these tests may indicate liver damage, hepatitis, cirrhosis, or other liver diseases. Early detection through the Hepatic Function Panel allows for timely treatment, leading to better outcomes.

Monitoring Side Effects of Medicines on Liver

Regular monitoring of liver function is crucial for patients taking medications that may impact liver health. A hepatic function panel can help identify early indications of medication-induced liver damage and provide healthcare professionals with information about medication dosages or alternative treatments. This panel is recommended when starting new medications that have known hepatotoxicity. By monitoring liver function, healthcare providers can take proactive steps to prevent further liver damage and ensure the overall health of the patient's liver. It is important to prioritize the monitoring of liver function in individuals on medication to mitigate potential side effects and maintain the well-being of the liver.

Decoding the Results: What Do High or Low Levels Indicate?

High or low levels of liver enzymes in a hepatic function panel could indicate liver damage, disease, or decreased liver function. Abnormal bilirubin levels may suggest issues with the liver or bile ducts. Consult a healthcare professional for a thorough interpretation of the results.

What is the normal range for liver function tests?

The normal range for liver function tests can vary depending on the specific markers being measured. Generally, a healthy liver will have values within the normal range for markers like ALT, AST, bilirubin, albumin, and alkaline phosphatase. Consult with a healthcare professional to interpret your results and determine any further action needed.

Factors Affecting the Test Results

High or low levels of liver enzymes in the hepatic function panel can indicate liver damage or dysfunction. Factors such as medication use or alcohol consumption can affect the test results. Inflammation or infection in the liver can cause abnormal levels in the hepatic function panel. Certain medical conditions, like hepatitis or cirrhosis, can also impact the test results. It's important to consider the patient's medical history and lifestyle factors when interpreting the test results.

The Effect of Resistance Exercise on Liver Function Tests

Weight traning can increase liver enzymes, specifically on liver enzymes such as ALT and AST. These enzymes may show temporary increases after resistance exercise, but it is important to note that these increases are typically within the normal range and not a cause for concern. In fact, regular resistance exercise has been shown to improve liver health and reduce the risk of fatty liver disease. So, incorporating resistance exercise into your fitness routine can have positive effects on both your overall health and the health of your liver.

How Should One Prepare for this Test?

To prepare for a hepatic function panel, follow specific instructions given by your healthcare provider or the testing facility. Generally, fasting for a certain period may be required. Avoid alcohol and certain medications that can affect liver function before the test. Inform your healthcare provider about any supplements or herbal remedies you are taking.

Interfering Factors

Certain factors can interfere with the accurate interpretation of a hepatic function panel. Medications, such as certain drugs or supplements, can affect the results, so it's crucial to inform your healthcare provider about any medications you are taking. Heavy alcohol consumption can also impact liver function, potentially skewing the hepatic function panel results. It's important to disclose any relevant medical conditions, such as hepatitis or liver disease, as they can influence the results. Additionally, age and gender can sometimes affect the reference ranges used to interpret the hepatic function panel results. Your healthcare provider will take these factors into consideration when evaluating your test results.

How to Buy an Affordable Hepatic Function Panel on DiscountedLabs.com

If you're looking to buy an affordable hepatic function panel, DiscountedLabs.com is an excellent option to consider. A hepatic function panel is a crucial test for assessing liver health and detecting any potential liver diseases. Regular testing is essential for the early detection and prevention of such conditions. DiscountedLabs.com offers cost-effective options for purchasing hepatic function panel tests online. Ordering is easy, with step-by-step instructions provided on their website. The convenience and accessibility of online testing, as well as the quick turnaround for receiving test results, make DiscountedLabs.com a convenient choice.

Conclusion

In conclusion, understanding the hepatic function panel is crucial for monitoring and maintaining liver health. This comprehensive test provides valuable insights into the functioning of key components such as total protein, albumin, bilirubin, AST, ALT, ALP, and GGT. By analyzing the results, healthcare professionals can identify liver injury, disease, and monitor the side effects of medications on the liver.

It's crucial to remember that certain factors can affect the test results, so a qualified healthcare provider should interpret these results. Factors like resistance exercise and other interfering factors should be taken into consideration.

If you're looking to get an affordable hepatic function panel, visit DiscountedLabs.com. They offer discounted rates and provide a convenient and reliable way to access this essential test. Prioritize your liver's health and take proactive steps towards maintaining a healthy lifestyle.

This hormone panel for men on testosterone replacement therapy (TRT) contains upstream and downstream hormones to testosterone.  TRT has been shown to decrease upstream hormones like pregnenolone and progesterone, and slightly decrease DHEA. Downstream hormone metabolites like ultrasensitive estradiol and DHT are also included.  Lastly, prolactin is added since high prolactin can decrease sexual function.  No LH and FSH were included since TRT shuts them down.

Several of the hormone tests (estradiol, testosterone, pregnenolone, progesterone, & DHT) included in this panel are done using liquid chromatography/mass spectrometry since they are more precise at high and low values and have no interences.

You can add an IGF-1 test and 17-OH-progesterone test to your cart for an even more complete picture.

• DHEA-S Test

Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal gland. It is also made in the brain. DHEA leads to the production of androgens and estrogens (male and female sex hormones). DHEA levels in the body begin to decrease after age 30. Lower DHEA levels are found in people with hormonal disorders, HIV/AIDS, Alzheimer's disease, heart disease, depression, diabetes, inflammation, immune disorders, and osteoporosis. Corticosteroids, birth control taken by mouth, and agents that treat psychiatric disorders may reduce DHEA levels.  Do you need to take a DHEA supplement?

• Estradiol Test (Ultra-Sensitive) Test (LC/MS)

Estradiol is the predominant sex hormone present in females and is also found at lower levels in men. It represents the major estrogen in humans. Estradiol not only impacts reproductive and sexual functioning, but also affects other systems including bone health, heart health, nerves and metabolism. Estradiol, also known as E2, is the most active of all three estrogens commonly measured in a clinical setting. For women, it is important to compare the relationship between estradiol and progesterone in evaluating menopausal symptoms such as hot flashes, mood disorders, and aging skin. In both men and women, low levels of estradiol are associated with osteoporosis. More information: Estradiol in Men: Top Ten Things You Should Know

• Progesterone Test

Progesterone is a female hormone important for the regulation of ovulation and menstruation. It is also present in men in smaller concentrations. This test is performed using the immunoassay technology. Progesterone is used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body. This hormone is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy. Progesterone replacement may also be used for other purposes. TRT may lower progesterone in men.  Progesterone may have a calming effect in men, so some researchers speculate that decreasing progesterone levels in men may affect mood, sleep quality and anxiety.

• Pregnenolone Test- Sensitive (LC/MS)

Pregnenolone is the mother of all hormones. It is known as a neurosteroid with brain health benefits.  As most hormones, it decreases with age. Aside from the natural decrease in pregnenolone that occurs as you age, research shows that higher doses of Testosterone Replacement Therapy (TRT) cause pregnenolone levels to drop even further. 

This pregnenolone lab test uses liquid chromatography, so it is accurate for the measurement of pregnenolone. Pregnenolone is known as the mother hormone. All other steroids including testosterone and estrogen are derived from this important hormone. For this reason, optimal blood levels of pregnenolone are critical for a healthy hormone balance.

However, pregnenolone does more. It is important for proper brain development, cognition, memory, and mood. These dramatic effects on the brain are why pregnenolone is known as a neuro-active steroid.

Fasting is not required. Pregnenolone supplementation should be taken approximately 2 hours before the blood draw. More on the role of pregenolone in men.

• Total Testosterone, LC/MS

• Free Testosterone by Equilibrium Ultrafiltration

This panel includes total testosterone measured by the most accurate method for women (liquid chromatography/mass spectrometry), free testosterone percent by equilibrium ultrafiltration, and free testosterone calculated from percent free T. Food may temporily low testosterone blood levels in men not on TRT.

• Dihydrotestosterone (DHT) (LC/MS)

DHT is synthesized from testosterone in the prostate gland, testes, hair follicles, and adrenal glands by 5-alpha reductase. Dihydrotestosterone exerts its action similar to testosterone, which binds to and activates androgen receptors. Dihydrotestosterone is responsible for the formation of male primary sex characteristics and most male secondary sex characteristics during puberty, such as muscular growth, facial and body hair growth, and deepening of the voice.

Excess DHT has been associated with hair loss, prostate volume increase, and acne in men with a genetic predisposition to those issues. Blocking or decreasing DHT to low levels may cause sexual dysfunction. Please read DHT: Friend or Enemy of Men?

• Prolactin Test

Prolactin is secreted by the pituitary gland to induce milk production. It also has many other functions on immune response, myelin coating on nerves, heart muscle protection, and enhances LH receptors on testicular Leydig cells so that testosterone can be produced. 

Prolactin levels peak during REM sleep, and in the early morning. Levels can rise after exercise, meals, sexual intercourse, minor surgical procedures, or following epileptic seizures. 

High prolactin can decrease testosterone and cause sexual dysfunction. Higher levels of prolactin have been associated with tumors involving the lungs, the pituitary gland, and the kidneys. Prolactin is sometimes used by doctors to evaluate sexual dysfunction of unknown cause in both men and women.

Drugs, supplements and certain diseases like pituitary adenomas may disrupt normal prolactin blood levels. These include hypothyroidism, antiepileptics, antidepressants, estrogen, opiates, diuretics, certain growth hormone releasing peptides and arginine. More on the role of prolactin in men.

Hormone Test Panel for Men

DiscountedLabs.com is proud to offer the Hormone Test Panel for Men, designed specifically for understanding and evaluating male hormonal health. This panel incorporates the most accurate assays, regarded as the gold standard in hormone measurement, offering insights that can guide medical decisions regarding hormonal imbalances, aging, sexual health, and overall well-being.

Tests Included:

1. Total Testosterone (Liquid chromatography/MS-MS): The total testosterone test using LC/MS-MS technology provides an accurate evaluation of this vital male hormone. Monitoring testosterone levels is essential for understanding energy levels, sexual health, mood, and muscle mass.

2. Free Testosterone (Equilibrium Ultrafiltration): This test measures the unbound, active portion of testosterone that plays a crucial role in sexual function, mood regulation, and physical performance.

3. Sex Hormone-Binding Globulin (SHBG): SHBG binds to sex hormones like testosterone and estradiol. Evaluating SHBG levels helps in understanding how much testosterone is freely available in the body.

4. Estradiol, Ultra Sensitive (LC/MS-MS): An advanced test that accurately measures estradiol, a form of estrogen. Understanding estradiol levels in men helps evaluate the balance of sex hormones, critical for heart health, bone density, and more.

5. DHT Level (LC/MS): DHT or dihydrotestosterone is a powerful form of testosterone. Monitoring DHT levels can provide insights into conditions like hair loss and prostate health.

6. Prolactin: Prolactin plays a role in various functions, including reproductive health. Elevated prolactin levels can impact sexual function, fertility, and may indicate underlying health concerns.

7. Dehydroepiandrosterone Sulphate (DHEA-S): DHEA-S is an essential adrenal hormone. Testing DHEA-S levels assists in evaluating adrenal function, aging, and its influence on sexual and metabolic health.

Why Choose Our Hormone Test Panel for Men?

Our Hormone Test Panel for Men offers a comprehensive look at the essential hormones influencing male health. It is an invaluable tool for those seeking to:

• Evaluate Sexual Health: Monitor testosterone and related hormones for optimal sexual function.
• Understand Aging Effects: Hormones like DHEA-S and testosterone are essential for understanding the aging process and age-related conditions.
• Monitor Prostate and Hair Health: The DHT level test provides information related to prostate health and hair loss. DHT is also linked to sex drive.
• Assess Overall Well-being: Hormones play a vital role in energy, mood, metabolism, and more. This panel helps in identifying hormonal imbalances that may affect your daily life.

Get Started with DiscountedLabs.com

At DiscountedLabs.com, we prioritize quality and affordability. Our Hormone Test Panel for Men is not only budget-friendly but also employs the most accurate testing methods available in modern medicine.

Take control of your hormonal health with the insights provided by our Hormone Test Panel for Men. Schedule your appointment today at DiscountedLabs.com and embark on a path toward better understanding and managing your unique hormonal profile.

This inflammation lab test panel includes:

C-Reactive Protein (CRP) –  CRP is a substance produced by the liver that increases in the presence of inflammation in the body. This test helps to diagnose and monitor the activity of some inflammatory and infectious conditions—arterial damage results from white blood cell invasion and inflammation within the wall. CRP is a general marker for inflammation and infection, so it can be used as a very rough proxy for heart disease risk. The American Heart Association and U.S. Centers for Disease Control and Prevention have defined risk groups based on CRP: Low Risk: less than 1.0 mg/L, Average risk: 1.0 to 3.0 mg/L, High risk: above 3.0 mg/L. CRP can also be increased by sleep apnea, rheumatoid arthritis, colon cancer, and inflammatory bowel disease.

CK- Creatine Kinase (or Creatine Phosphokinase – CPK)- Creatine phosphokinase is an enzyme in the heart, brain, and skeletal muscle. It is tested by taking a blood sample. High CPK can indicate muscle destruction and inflammation, heart attacks, and central nervous system issues. 

Ferritin- Serum ferritin is a screening tool to detect iron deficiency. Serum ferritin values in the 200–2000 ng/ml range may be increased due to non-iron-related factors, including inflammation and obesity.

Homocysteine- A high level of homocysteine in the blood (hyperhomocysteinemia) makes a person more prone to endothelial cell injury, leading to inflammation in the blood vessels, which may lead to plaque build-up inside blood vessels. Hyperhomocysteinemia is, therefore, a possible risk factor for coronary artery disease since it has been correlated with blood clots, heart attacks, and strokes.

Lactic Acid Dehydrogenase (LDH)- LDH is an enzyme, or catalyst, found in many body tissues involved in energy production. These include red blood cells, skeletal muscles, heart, kidneys, brain, and lungs. LDH is most often measured to check for tissue damage. LDH is in many body tissues, especially the heart, liver, kidney, muscles, brain, blood cells, and lungs. An elevated level of LDH may be seen with:  Anemia, infections (such as infectious mononucleosis (mono), meningitis, encephalitis, and HIV), sepsis, intestinal and lung (pulmonary) infarction, kidney disease, liver disease, muscle injury, pancreatitis, cancers, and bone fractures.

Erythrocyte Sedimentation Rate (by Westergren) (ESR)-  ESR is the rate at which red blood cells sediment in a period of one hour. To perform the test, anticoagulated blood was traditionally placed in an upright tube, known as a Westergren tube, and the rate at which the red blood cells fall was measured and reported in mm/h. The ESR is increased in inflammation, pregnancy, anemia, autoimmune disorders (such as rheumatoid arthritis and lupus), infections, kidney diseases, and cancers (such as lymphoma and multiple myeloma). The ESR is decreased in polycythemia, hyperviscosity, sickle cell anemia, leukemia, low plasma protein (due to liver or kidney disease), and congestive heart failure.

The iron panel includes the serum iron test measures the amount of iron in your blood and the total iron-binding capacity (TIBC test) test that looks at how well the iron moves through your body.

Iron Panel: Why is Iron Important for Health?

Iron is an important mineral that your body needs to stay healthy. Your body uses iron to make hemoglobin, the protein in your red blood cells that carries oxygen throughout your body. If you don't have enough iron, you may not have enough hemoglobin. This condition is called iron deficiency anemia.

Iron in your body is carried, or bound, mainly to a protein made by your liver called transferrin. The TIBC test is based on certain proteins, including transferrin, found in the blood. Your transferrin levels are almost always measured along with iron and TIBC.

Iron plays a principal role in erythropoiesis, the formation and maturation of red blood cells (RBCs) and is required for hemoglobin synthesis. The human body contains between four and five grams of iron, about 65% of which is present in hemoglobin and 3% of which is present in myoglobin, the oxygen storage protein found in skeletal muscle and cardiac muscle. A small amount is also found in cellular enzymes that catalyze the oxidation and reduction of iron. Excess iron is stored in the liver and spleen as ferritin and hemosiderin. Any iron present in the serum is in transit between the digestive track and bone marrow, and available iron stores forms. Sixty to 70% of the body's iron is carried by its specific transport protein, transferrin. For this reason, total iron binding capacity (TIBC) and transferrin are sometimes referred to interchangeable, even though other proteins carry iron and contribute to the TIBC.

Unbound iron is highly toxic, but there is generally an excess of transferrin available to prevent the buildup of unbound iron in the circulation. The percentage of iron saturation is calculated by dividing the serum iron value by the TIBC value and multiplying it by 100.

What is Iron Deficiency?

Iron deficiency, or sideropenia, is the state in which a body lacks enough iron to supply its needs. Iron is present in all cells in the human body and has several vital functions, such as carrying oxygen to the tissues from the lungs as a key component of the hemoglobin protein, acting as a transport medium for electrons within the cells in the form of cytochromes, and facilitating oxygen enzyme reactions in various tissues. Too little iron can interfere with these vital functions and lead to morbidity and death.

Total body iron averages approximately 3.8 g in men and 2.3 g in women. In blood plasma, iron is carried tightly bound to the protein transferrin. There are several mechanisms that control iron metabolism and safeguard against iron deficiency. The main regulatory mechanism is situated in the gastrointestinal tract. The majority of iron absorption occurs in the duodenum, the first section of the small intestine. A number of dietary factors may affect iron absorption. When loss of iron is not sufficiently compensated by intake of iron from the diet, a state of iron deficiency develops over time. When this state is uncorrected, it leads to iron-deficiency anemia, a common type of anemia. Before anemia occurs, the medical condition of iron deficiency without anemia is called latent iron deficiency (LID).

Anemia is a condition characterized by inadequate red blood cells (erythrocytes) or hemoglobin. When the body lacks sufficient amounts of iron, production of the protein hemoglobin is reduced. Hemoglobin binds to oxygen, enabling red blood cells to supply oxygenated blood throughout the body. Women of child-bearing age, children, and people with poor diet are most susceptible to the disease. Most cases of iron-deficiency anemia are mild, but if not treated can cause problems like an irregular heartbeat, pregnancy complications, and delayed growth in infants and children that could affect their cognitive development and their behavior.

Symptoms of Low Iron:

Symptoms of iron deficiency can occur even before the condition has progressed to iron deficiency anemia.

Symptoms of iron deficiency are not unique to iron deficiency. Iron is needed for many enzymes to function normally, so a wide range of symptoms may eventually emerge, either as the secondary result of the anemia, or as other primary results of iron deficiency. Symptoms of iron deficiency include:

• fatigue
• dizziness/lightheadedness
• pallor
• hair loss
• twitches
• irritability
• weakness
• pica
• brittle or grooved nails
• hair thinning
• Plummer–Vinson syndrome: painful atrophy of the mucous membrane covering the tongue, the pharynx and the esophagus
• impaired immune function
• pagophagia (compulsive ice chewing)
• restless legs syndrome

Continued iron deficiency may progress to anemia and worsening fatigue. Thrombocytosis, or an elevated platelet count, can also result. A lack of sufficient iron levels in the blood is one reason that some people cannot donate blood.

Symptoms of High Iron- Overload

Iron overload or hemochromatosis indicates accumulation of iron in the body from any cause. The most important causes are hereditary haemochromatosis (HHC), a genetic disorder, and transfusional iron overload, which can result from repeated blood transfusions.

Organs most commonly affected by haemochromatosis include the liver, heart, and endocrine glands.

Hemochromatosis may present with the following clinical syndromes:

• liver: chronic liver disease and cirrhosis of the liver.
• heart: heart failure, cardiac arrhythmia.
• hormones: diabetes (see below) and hypogonadism (insufficiency of the sex hormone producing glands) which leads to low sex drive and/or loss of fertility in men and loss of menstrual cycle in women.
• metabolism: diabetes in people with iron overload occurs as a result of selective iron deposition in islet beta cells in the pancreas leading to functional failure and cell death.
• skeletal: arthritis, from calcium pyrophosphate deposition in joints leading to joint pains. The most commonly affected joints are those of the hands, particularly the knuckles of the second and third fingers.
• skin: melanoderma (darkening or 'bronzing' of the skin).
• The skin's deep tan color, in concert with insulin insufficiency due to pancreatic damage, is the source of a nickname for this condition: "bronze diabetes"

What Can the Iron and TIBC Test Diagnose?

• Assist in the diagnosis of iron deficiency anemia.
• Differentiate between iron deficiency anemia and anemia secondary to chronic disease.
• Monitor hematological response to therapy during pregnancy and iron deficiency anemias.
• Provide support for diagnosis of hemochromatosis or diseases of iron metabolism and storage.

What Can Increase Iron Test Levels?

• Acute liver disease.
• Hypochromic iron-deficiency anemias.
• Late pregnancy.
• Testosterone therapy via increased hemoglobin and hematocrit.

 What Can Decrease Iron Test Levels?

Iron is decreased in chronic infections, cirrhosis, hemochromatosis, hemolytic anemias, neoplastic diseases, protein depletion, renal disease, excessive menstruation, frequent blood donations and internal bleeding.

What Medications Can Increase or Decrease TIBC Test Results?

• Drugs that may increase TIBC levels include mestranol and oral contraceptives.
• Drugs that may decrease TIBC levels include which is asparaginase, corticotropin, cortisone, and testosterone.

Lactate dehydrogenase (LD) is an enzyme that is found in almost all of the body's cells, but only a small amount of it is usually detectable in the blood. LD is released from the cells into the bloodstream when cells are damaged or destroyed. Because of this, the LD test can be used as a general marker of injury to cells.

Although there is some overlap, each of the five LD isoenzymes tends to be concentrated in specific body tissues. In general, the isoenzyme locations are as follows:

• LD1: Heart, red blood cells, kidney

• LD2: Heart, red blood cells, kidney (lesser amounts than LD1)

• LD3: Lungs and other tissues

• LD4: White blood cells, lymph nodes, muscle, liver (lesser amounts than LD5)

• LD5: Liver, skeletal muscle

Changes of LD isoenzymes periodically measured following onset of chest pain, studying the relationships of the anodic fractions, provide important information for the differential diagnosis of acute infarct of myocardium. The differential diagnosis of certain other diseases is enhanced as well with the use of LD isoenzymes.

Useful in the differential diagnosis of acute myocardial infarction, megaloblastic anemia (folate deficiency, pernicious anemia), hemolytic anemia, and very occasionally renal infarct. These entities are characterized by LD1 increases, often with LD1:LD2 inversion.

The isomorphic pattern (total LD significantly high with no increase in percentage, of any fraction) is seen with neoplasia, cardiorespiratory diseases, hypothyroidism, infectious mononucleosis, and other inflammatory states, uremia, and necrosis.

LD5 increases are seen with striated muscle lesions (eg, trauma) and with liver diseases (eg, hepatic congestion, congestive heart failure, hepatitis, cirrhosis, alcoholism). LD5 increase is probably more significant when the LD5:LD4 ratio is increased.

Although a modicum of controversy exists regarding the most suitable criteria for LD isoenzymes for the diagnosis of acute myocardial infarction, almost all laboratories recognize abnormality when LD1 equals or is greater than LD2. Alternatives to LD1 greater than LD2 have been proposed. Using an electrophoretic method (Helena), Rotenberg et al suggested the criterion of LD1 >90 units/L. A 1988 study examines application of LD1:LD4 and other ratios and finds that the LD1:LD4 ratio optimizes earlier and is the most powerful diagnostic ratio for acute myocardial infarction.

A few percent of normal individuals may have LD1:LD2 ratios as high as 0.81. A ratio of 0.82−0.99 is suspicious of myocardial injury. A ratio >1.0 is diagnostic of myocardial injury, if other clinical criteria are met. In unstable angina, an increase of the LD1:LD2 ratio is described with normal total LD;3 however, progressively increasing LD1:LD2 ratio without complete inversion may have diagnostic significance for acute myocardial infarct.

Persistent LD1:LD2 flip following acute myocardial infarct may represent a marker for reinfarction. Especially when acute myocardial infarction is complicated by shock, the isomorphic pattern may be found.6 LD1:LD2 inversion commonly appears subsequent to the isomorphic pattern in instances of acute myocardial infarction.

The appearance of an LD “flip” (when LD1 is greater than LD2) is extremely helpful in diagnosis of MI. The presence of a LD “flip” a day following or with the detection of CK-MB is essentially diagnostic of MI, if baseline cardiac enzymes/isoenzymes are normal and if rises and falls are as anticipated for the diagnosis of acute MI. While CK-MB peaks 12 to 24 hours after onset of infarction, LD isoenzymes usually become diagnostic at about 36 to 55 hours after onset and return to normal between 3 and 14 days after onset.

The pituitary gland produces FSH and LHto control the production of sex hormones, including testosterone and estrogen. FSH and LH regulate the body's development, growth, and reproductive processes. In aging men and women, a rise in FSH and LH may indicate the onset of menopause and/or andropause. In women still menstruating, low levels of FSH and LH may indicate excessive estrogen and may lead to estrogen dominance. There is an increased risk for disorders such as polycystic ovarian disease and fibrocystic breast disease in this hormonal state.

This test is not helpful for men and women on testosterone therapy since TRT suppresses both values.

NOTE: If you are taking biotin, please stop it 72 hours before the blood draw since it may interfere with hormone blood tests.

The lipid panel is used to determine the likelihood of developing coronary heart disease and atherosclerosis (also known as arterial plaque). This test measures things like total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, and the ratio of total cholesterol to HDL cholesterol.

For this test, you need to abstain from food (only water) for 8 hours.

A lipid panel is an essential diagnostic tool that provides crucial information about your cardiovascular health. This comprehensive blood test measures various types of fat in your bloodstream, helping to identify potential risks for heart disease and other cardiovascular problems. In this blog post, we will explore the significance of a standard lipid panel and provide an in-depth analysis of its components, interpretation of results, and advantages associated with regular testing.

Throughout this article, you'll learn how to interpret your lipid panel results and discover the benefits associated with regular testing. We will also discuss what's included in a typical lipid profile and provide guidance on how to prepare for the test effectively. Finally, we'll share valuable resources on obtaining affordable lipid panel tests through Discounted Labs.

With this understanding, you can gain power over your heart health by keeping an eye on and controlling your cholesterol levels more effectively.

Table of Contents:

• Understand Your Lipid Panel Results
  • Components of a Lipid Panel
  • Risk Factors & Recommendations
  • Next Steps after Receiving Your Results
• Benefits of a Lipid Panel Test
  • Early Detection of Cardiovascular Risks
  • Monitoring Treatment Progress
  • Guiding Lifestyle Changes
• What's in a Lipid Panel?
  • Total Cholesterol
  • Low-Density Lipoprotein (LDL) Cholesterol
  • High-Density Lipoprotein (HDL) Cholesterol
  • Triglycerides
  • Non-HDL Cholesterol
• How to Prepare for a Lipid Panel Test
  • Dietary Restrictions
  • Fasting Requirements
• Get Affordable Lipid Panel Tests with Discounted Labs
  • Affordable Pricing
  • No Doctor's Visit Required
  • Convenient Locations Across the U.S.
• FAQs in Relation to Lipid Panel
  • The Lowdown on Lipid Panels
• Conclusion

Understand Your Lipid Panel Results

So, you got your lipid panel results back, and now you're wondering what the heck they mean? You can feel reassured that we have everything under control. The lipid panel is an essential blood analysis that assesses the levels of diverse fats present in your bloodstream, including cholesterol and triglycerides.  Here's what you need to know:

Components of a Lipid Panel

• Total Cholesterol: This is the sum of all cholesterol types found in your blood. A desirable level is below 200 mg/dL.
• HDL Cholesterol: Known as "good" cholesterol, higher levels of HDL are associated with lower risk for heart disease; aim for at least 60 mg/dL.
• LDL Cholesterol: Low-density lipoprotein, or "bad" cholesterol, contributes to plaque buildup on artery walls, which can lead to heart attacks and strokes. It's important to keep LDL levels low—ideally under 100 mg/dL.
• Triglycerides: The body uses these fats as a source of energy, but when they are present in excessive amounts, they can also cause cardiovascular problems. Aim for less than 150 mg/dL.

Risk Factors & Recommendations

Your doctor will consider various factors like age, family history, smoking habits, and blood pressure status while assessing your lipid panel results before providing personalized recommendations based on guidelines such as those provided by the American Heart Association (AHA). However, some general guidelines include:

• If your total cholesterol is between 200 and 239 mg/dL or your LDL cholesterol is between 130 and 159 mg/dL, you may be at borderline risk for heart disease.
• When total cholesterol exceeds 240 mg/dL or LDL levels are above 160 mg/dL, the risk of developing heart disease significantly increases.

It is likewise crucial to look at the proportion of HDL to total cholesterol. A higher ratio indicates a lower risk of heart problems. To calculate this ratio, divide your total cholesterol by your HDL level; a desirable result would be below five (Mayo Clinic).

Next Steps after Receiving Your Results

If your lipid panel results indicate that you're at increased risk for cardiovascular issues, don't panic. Take proactive steps to improve your health, such as changing your diet, exercising regularly, quitting smoking if applicable, managing stress levels effectively, and maintaining a healthy body weight. Consider making lifestyle changes such as adopting a healthier diet rich in fruits and veggies while reducing saturated fat intake, exercising regularly, quitting smoking if applicable, managing stress levels effectively, and maintaining a healthy body weight. Additionally, consult with healthcare professionals who can provide guidance on medication options if necessary.

Benefits of a Lipid Panel Test

Take proactive measures now to safeguard your health and wellbeing. A lipid panel test is a simple blood test that can provide valuable information about your cholesterol levels and overall cardiovascular health. Here are some of the benefits of getting a lipid panel test:

Early Detection of Cardiovascular Risks

By getting a lipid panel test, you can detect potential risks early and take steps to protect your cardiovascular health, providing invaluable insight into the future of your wellbeing. It's like having a crystal ball for your health.

Monitoring Treatment Progress

If you're already taking medication to manage your cholesterol, regular lipid panel tests can help you and your healthcare provider monitor the effectiveness of your treatment plan. It's like having a personal cheerleader cheering you on.

Guiding Lifestyle Changes

Your lipid panel results can serve as a valuable tool for guiding lifestyle changes aimed at improving overall health. It's like having a personal coach help you make healthy choices.

Don't put off taking care of your health any longer. Discounted Labs offers affordable options for lipid panel tests, so there's no excuse not to take control of your well-being today. Click here to learn more.

What's in a Lipid Panel?

A lipid panel, otherwise referred to as a lipoprotein profile or lipid profile, is a blood test that evaluates the concentrations of various types of fats (lipids) in your bloodstream. These measurements can help assess your risk for heart disease and other health issues related to high cholesterol levels. Let's dive into the components of a lipid panel test and what each component measures.

Total Cholesterol

The total cholesterol measurement includes all the different types of cholesterol found in your blood. This figure offers a broad indication of the amount of cholesterol flowing in your blood, but it does not show any particulars regarding particular sorts of cholesterol like LDL ("bad") or HDL ("good"). High total cholesterol levels may pose a greater risk of developing cardiovascular diseases.

Low-Density Lipoprotein (LDL) Cholesterol

LDL cholesterol, plaque buildup on artery walls due to LDL cholesterol, also known as "bad" cholesterol, pose a serious risk for arterial narrowing or blockage over time. This can increase the likelihood of experiencing a heart attack or stroke.

High-Density Lipoprotein (HDL) Cholesterol

HDL cholesterol, commonly called "good" cholesterol, helps remove LDL cholesterol from your bloodstream and carries it back to the liver for disposal. Higher HDL blood levels are associated with a lower risk of heart disease.

Triglycerides

Triglycerides are another type of fat found in your blood that can contribute to the hardening or narrowing of arteries if present in high amounts. High levels of triglycerides may boost the chance of heart disease, notably when combined with reduced HDL or elevated LDL cholesterol levels.

Non-HDL Cholesterol

This measurement is calculated by subtracting your HDL cholesterol level from your total cholesterol level. Non-HDL cholesterol includes all other types of circulating cholesterol (such as LDL) that can potentially contribute to plaque buildup in the arteries. Some healthcare providers consider non-HDL cholesterol an important marker for cardiovascular risk assessment, particularly in individuals with elevated triglyceride levels.

Some tests of lipid composition include measurements such as ApoB, Lp(a), and small, dense LDL particles, which can help give a better understanding of particular types of lipids linked with heart disease risk factors.

At Discounted Labs, our lipid panel test provides accurate results at affordable prices, so you can take control of your health without breaking the bank. Stay informed about your lipid profile and make informed decisions regarding diet, exercise, and lifestyle changes necessary for maintaining optimal cardiovascular health.

How to Prepare for a Lipid Panel Test

A lipid panel test is crucial for assessing your cholesterol levels and overall heart health. To ensure accurate results, it's essential to prepare for the test by following specific guidelines. Let's discuss how to prepare for a lipid panel test, including dietary restrictions and fasting requirements.

Dietary Restrictions

Before taking a lipid panel test, avoid consuming foods that can affect your cholesterol levels. Choosing foods high in trans and saturated fats may have undesirable effects on our overall well-being. Such foods can promote negative changes, such as raising LDL, or "bad" cholesterol. While reducing the presence of HDL, or "good" cholesterol.So, say no to:

• Fried foods
• Fatty cuts of meat
• Processed meats like hot dogs and sausages
• Baked goods made with hydrogenated oils or shortening
• Cream-based sauces and dressings

Instead, focus on incorporating heart-healthy options into your diet leading up to the test, such as:

• Fruits and vegetables rich in fiber, which can help lower bad cholesterol levels, include:
  • Broccoli
  • Brussels sprouts
  • Apples
  • Pears
• Omega-3 fatty acids found in fish like salmon or mackerel
• Nuts such as almonds or walnuts
• Use olive oil instead of butter when cooking

Fasting Requirements

Most lipid panel tests require fasting for 9–12 hours before the test. So, schedule your test for the morning and avoid eating or drinking anything except water after dinner the night before. Remember, accurate results depend on proper preparation.

Get Affordable Lipid Panel Tests with Discounted Labs

Don't let high costs stop you from taking control of your health. With Discounted Labs, you can get an accurate assessment of your cholesterol levels without breaking the bank.

Affordable Pricing

At Discounted Labs, they believe that everyone should have access to affordable healthcare services, including lab testing. That's why they offer competitive pricing on all their tests, including lipid panels.

No Doctor's Visit Required

Save time and money by not having to schedule an appointment with your physician just to order a lipid panel test. With Discounted Labs, you don't need a doctor's visit or prescription to order a test.

Convenient Locations Across the U.S.

With over 1,800 patient service centers across most cities in the United States (except New York), finding a convenient location for your lab test is easy. Simply purchase your test online and locate the nearest patient service center using their online search tool.

How It Works:

1. Purchase your test: Choose from various available options, like the Basic Lipid Panel or Comprehensive Metabolic Panel + Lipids, depending on what suits your needs best.
2. Find a Lab Near You: Locate the nearest patient service center using their online search tool and choose the most convenient location for you.
3. Get Tested: Bring your lab requisition form (emailed after purchase) to the chosen patient service center, where they will collect a blood sample for testing. No appointment is necessary.
4. Receive Your Results: Within a few working days, you will be sent an email with the outcomes of your examination through Discounted Labs' secure entryway.

Discounted Labs also offers various other health-related tests, such as hormone panels, thyroid function tests, vitamin deficiency assessments, and more. By providing affordable and accessible lab testing options without compromising on quality or accuracy of results, Discounted Labs empowers individuals to take proactive charge of their health.

If you're interested in getting regular lipid panel tests or any other type of lab work done at discounted prices without sacrificing convenience or quality care, visit DiscountedLabs.com today.

FAQs in Related to Lipid Panel

The Lowdown on Lipid Panels

A lipid panel measures cholesterol and triglyceride levels to assess your risk for heart disease and stroke.

The four major results of a lipid panel are total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides.

Physicians order lipid panels to evaluate cardiovascular disease risk, monitor existing conditions, and gauge treatment effectiveness.

The four categories in a lipid panel are total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides.

Each category plays a different role in your overall cardiovascular health and risk assessment.

Stay informed and learn more about lipid panels here.

Conclusion

At Discounted Labs, we offer affordable lipid panel tests that are easy to order online. Don't wait until it's too late to take control of your health!

Preparing for a lipid panel test is important to ensure accurate results; learn what's included and how to prepare.

Improving your overall wellness starts with knowing your cholesterol levels. Get tested today and take the first step.

Don't let high cholesterol catch you off guard; identify potential risks with a lipid panel test from Discounted Labs.

Take charge of your health with an affordable lipid panel test from Discounted Labs—order online now!

Stay ahead of heart disease by monitoring your cholesterol levels. Get tested with Discounted Labs and take control of your health.

Don't let high cholesterol go unnoticed; get tested with Discounted Labs and start making positive changes to your health.

Knowledge is power when it comes to your health; order a lipid panel test from Discounted Labs and stay informed.

Take the first step towards a healthier you with a lipid panel test from Discounted Labs—it's easy, affordable, and convenient. You can also choose to buy an advanced lipid panel test called Cardio-IQ.

This panel provides a baseline overview of your sex hormones, thyroid gland, adrenal function, metabolic function, cholesterol, prostate, and overall health. It includes:

• CBC (includes immune cells, red blood cells, and hematocrit)
• CMP-14 (Includes kidney and liver function, glucose and electrolytes)
• Lipid Panel (LDL, HDL, Triglycerides) FASTING REQUIRED
• Testosterone free and total (LC/MS assay with no upper limit)
• Estradiol, Ultra Sensitive (LC/MS assay)
• DHEA-sulfate (Dehydroepiandrosterone Sulfate)
• TSH (Thyroid Stimulating Hormone)
• Free T3 (Free Triiodothyronine )
• PSA (Prostatic Specific Antigen)
• SHBG (Sex Hormone Binding Globulin)

This panel is often used to monitor men on TRT.  LH and FSH are not included since they are usually very low or zero on testosterone replacement.

Click here to find out how our process works.

IMPORTANT: Discounted Labs only serves these states: Find a Location 

Please read the following frequently asked questions before placing an order: FAQs

Free Book Download: Beyond Testosterone

Suggested Reading: Testosterone Replacement Blood Test Targets

Metformin Treatment Lab Panel: A Comprehensive Insight 

Metformin is a well-known medication that plays a vital role in the treatment of Type 2 diabetes. It has been clinically proven to enhance insulin sensitivity, endothelial function, liver health, cardiovascular protection, cholesterol regulation, weight loss, and inflammation reduction. The Metformin Treatment Lab Panel at DiscountedLabs.com is designed to provide a thorough evaluation for all patients who are to be administered Metformin. Here's a breakdown of each test in this panel, elucidating the essentials of diabetes management:

1. Comprehensive Metabolic Panel (CMP-14)

• Overview: CMP-14 encompasses 14 different blood tests serving as an introductory medical screening tool to assess general health.
• Components: Includes bilirubin (total), BUN, BUN: creatinine ratio, calcium serum, carbon dioxide (total), chloride serum, creatinine serum, eGFR calculation, globulin (total), glucose serum, potassium serum, protein (total, serum), and sodium serum.
• Purpose: Measures renal function, liver function, electrolyte balance, and fluid balance, offering a broad perspective on metabolic health.

2. Complete Blood Count (CBC)

• Overview: Among the most widely requested tests for routine checkups and physical examinations.
• Components: Analyzes red blood cells, white blood cells, platelets, hemoglobin, hematocrit, absolute lymphocytes, monocytes, neutrophils, eosinophils, basophils, and other blood indicators.
• Purpose: Essential for diagnosing and treating a diverse array of illnesses, emphasizing immunological health.

3. Hemoglobin A1C

• Overview: A critical component in diabetic management, assessing glucose levels in the bloodstream for the 2-3 months leading up to the test.
• Insight: Elevated hemoglobin A1c values generally indicate high glucose levels in the blood over the previous 2-3 months, offering valuable information on glycemic health.
• Importance: Helps in maintaining normal blood sugar levels, reducing associated risks and adverse effects in diabetes patients.

4. Insulin (Fasting)

• Overview: Measures insulin, vital for transferring glucose into body cells.
• Insight: Examines the body's primary energy source and the functioning of insulin in regulating blood sugar.
• Significance: Helps detect erratic blood sugar swings, often associated with diabetes, and understand symptoms like sweating, shaking, and lightheadedness.

5. Vitamin B12

• Overview: Essential for metabolism, energy, and stress management.
• Relation with Metformin: Metformin can sometimes reduce Vitamin B12 levels, potentially leading to anemia if the patient is already deficient.
• Importance: Monitoring Vitamin B12 levels while on Metformin can prevent potential deficiencies and associated complications.

Conclusion

The Metformin Treatment Lab Panel is a comprehensive collection of tests essential for individuals using Metformin for Type II Diabetes treatment. It provides a well-rounded view of overall health, focusing on critical areas affected by or related to diabetes.

At DiscountedLabs.com, we offer this panel to ensure that those seeking to regulate their blood sugar levels with Metformin have all the necessary information to do so safely and effectively. Trust in our advanced testing methods to provide accurate and insightful results. Visit us today to learn more about the Metformin Treatment Lab Panel and take a confident step in your diabetes management journey.

Epstein-Barr (EB) virus is a herpes group virus that is ubiquitous. It is the cause of classic infectious mononucleosis and is causally implicated in the pathogenesis of Burkitt lymphoma, some nasopharyngeal carcinomas, and rare hereditary lymphoproliferative disorders. The EBV test measures the serologic response to EB virus includes antibody to early antigen, IgM and IgG antibodies to viral capsid antigen (VCA), and antibodies to Epstein-Barr nuclear antigen (EBNA).

Although most cases of infectious mononucleosis can be diagnosed on the basis of clinical findings, blood count and morphology, and a positive EBV test for heterophile antibody, as many as 20% may be heterophile-negative, at least at presentation (Heterophile may become positive when repeated in a few days). In some of these cases, a test for Epstein-Barr virus antibodies may be useful.

The most controversial use of EBV serology is in chronic fatigue syndrome, a complaint predominantly (but not exclusively) of young to middle-aged women, characterized by long persistent debilitating fatigue and a panoply of usually mild somatic complaints. The high levels of EBV antibodies in the general population, their long persistence, and the poor correlation of antibody titers with symptoms combine to make EBV serology useless in diagnosing, following, or ruling out chronic fatigue syndrome. See table in project description.

Test Includes:

• Epstein-Barr Virus VCA Antibody (IgM), Epstein-Barr Virus VCA Antibody (IgG), Epstein-Barr Virus Nuclear Antigen (EBNA) Antibody (IgG)

Methodology

Immunoassay (IA)

Reference Range(s)

Epstein-Barr Virus VCA Antibody (IgM)

Epstein-Barr Virus VCA Antibody (IgG)

Epstein-Barr Virus Nuclear Antigen (EBNA) Antibody (IgG)

Epstein-Barr virus (EBV), also known as human herpesvirus 4, is a gamma herpes virus that occurs only in humans. Laboratory testing can help distinguish whether someone is susceptible to EBV infection or has a recent or past infection.

Healthcare providers can perform a EBV test for antibodies to the following EBV-associated antigens:

• Viral capsid antigen (VCA)
• Anti-VCA IgM appears early in EBV infection and usually disappears within four to six weeks.
• Anti-VCA IgG appears in the acute phase of EBV infection, peaks at two to four weeks after onset, declines slightly then persists for the rest of a person’s life.
• Early antigen (EA)
  Anti-EA IgG appears in the acute phase of illness and generally falls to undetectable levels after three to six months. In many people, detection of antibody to EA is a sign of active infection. However, 20% of healthy people may have antibodies against EA for years.
• EBV nuclear antigen (EBNA)
  Antibody to EBNA, determined by the standard immunofluorescent test, is not seen in the acute phase of EBV infection but slowly appears two to four months after onset of symptoms and persists for the rest of a person’s life. Other EBNA enzyme immunoassays may report false positive results.
• Monospot test
  The Monospot test is not recommended for general use. The antibodies detected by Monospot can be caused by conditions other than infectious mononucleosis. Moreover, studies have shown that the Monospot produces both false positive and false negative results. For example, the heterophile antibodies detected by Monospot are often not present in children with infectious mononucleosis. At best, the Monospot test may indicate that a person has a typical case of infectious mononucleosis, but does not confirm the presence of EBV infection.

Interpretation of EBV Tests

EBV antibody tests are not usually needed to diagnose infectious mononucleosis. However, specific antibody tests may be needed to identify the cause of illness in people who do not have a typical case of infectious mononucleosis or have other illnesses that can be caused by EBV infection. Symptoms of infectious mononucleosis generally resolve within four weeks. If a person is ill for more than six months and does not have a laboratory-confirmed diagnosis of EBV infection, other causes of chronic illness or chronic fatigue syndrome should be considered.

The interpretation of EBV antibody tests requires familiarity with these tests and access to the patient’s clinical information.

Interpretation of EBV antibody tests and diagnosis of EBV infection is summarized as follows:

• Susceptibility to infection
  People are considered susceptible to EBV infection if they do not have antibodies to the VCA.
• Primary (new or recent) infection
  People are considered to have a primary EBV infection if they have anti-VCA IgM but do not have antibody to EBNA. Other results that strongly suggest a primary infection are a high or rising level of anti-VCA IgG and no antibody to EBNA after at least four weeks of illness. Resolution of the illness may occur before the diagnostic antibody levels appear. In rare cases, people with active EBV infections may not have detectable EBV-specific antibodies.
• Past infection
  The presence of antibodies to both VCA and EBNA suggests past infection (from several months to years earlier). Since over 90% of adults have been infected with EBV, most adults will show antibodies to EBV from infection years earlier. High or elevated antibody levels may be present for years and are not diagnostic of recent infection.

Testing paired acute- and convalescent-phase serum samples is not useful to distinguish between recent and past EBV infections. In most cases, the antibody response occurs rapidly during primary EBV infection. The clinical findings of infectious mononucleosis occur in conjunction with the appearance of IgG and IgM anti-VCA antibodies. However, the antibody pattern is not stable before symptoms appear.

This osteoporosis panel includes:

• Serum total calcium, albumin (to calculate albumin adjusted calcium) and phosphorus as part of a CMP panel to detect conditions associated with hypercalcemia such as primary hyperparathyroidism or hypocalcemia and consequent secondary hyperparathyroidism causing bone loss
• Serum creatinine and estimated glomerular filtration rate (GFR) as part of the CMP panel are useful to detect renal failure which can affect bone health. 
• Serum alkaline phosphatase (ALP) as part of a CMP panel. ALP measurement is useful to detect conditions including Paget's disease, metastatic bone disease and osteomalacia, etc.
• Vitamin D nutrition should be determined by measuring serum 25-hydroxy vitamin D [25(OH)D]. Although there is controversy about the optimum level of 25(OH)D for bone health; while 50 nmol/L is considered acceptable
• Parathyroid Hormone (PTH) measurement would be required if serum calcium is abnormal, to help investigate the cause of the calcium abnormality.
• Ultra-sensitive Estradiol. Low estradiol in men and women has been linked to bone loss.
• Phosphorus. An increased phosphorus with decreased calcium suggests either hypoparathyroidism or renal disease. A decreased phosphorus and an increased calcium suggests hyperparathyroidism or sarcoidosis. When both calcium and phosphorus are decreased diagnostic considerations include malabsorption, vitamin D deficiency and renal tubular acidosis. Increased phosphorus and normal or increased calcium suggests Milk-alkali syndrome or hypervitaminosis D.

What is Osteoporosis?

Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to bone fragility, and consequent increase in fracture risk. It is the most common reason for a broken bone among the elderly.  Bones that commonly break include the vertebrae in the spine, the bones of the forearm, and the hip. Until a broken bone occurs there are typically no symptoms. Bones may weaken to such a degree that a break may occur with minor stress or spontaneously. After the broken bone heals, the person may have chronic pain and a decreased ability to carry out normal activities.

What Tests Can Diagnose Osteoporosis?

Absolute fracture risk in individual subjects is calculated by the use of algorithms which include bone mineral density (BMD), age, gender, history of prior fracture and other risk factors. This review describes the laboratory investigations into osteoporosis which include serum calcium, phosphate, creatinine, alkaline phosphatase and 25-hydroxyvitamin D and estradiol. Parathyroid hormone (PTH) is measured in patients with abnormal serum calcium to determine its cause. Other laboratory investigations such as thyroid function testing, screening for multiple myeloma, and screening for Cushing's syndrome, are performed if indicated. Measurement of bone turnover markers (BTMs) is currently not included in algorithms for fracture risk calculations due to the lack of data.

What Can Cause Osteoporosis?

Osteoporosis may be due to lower-than-normal maximum bone mass and greater-than-normal bone loss. Bone loss increases after menopause due to lower levels of estrogen. Osteoporosis may also occur due to a number of diseases or treatments, including alcoholism, anorexia, hyperthyroidism, kidney disease, and surgical removal of the ovaries. Certain medications increase the rate of bone loss, including some antiseizure medications, chemotherapy, proton pump inhibitors, selective serotonin reuptake inhibitors, and glucocorticosteroids. Smoking, and too little exercise are also risk factors. Osteoporosis is defined as a bone density of 2.5 standard deviations below that of a young adult. This is typically measured by dual-energy X-ray absorptiometry (DEXA).

Hypogonadal (low testosterone) states can cause secondary osteoporosis. These include Turner syndrome, Klinefelter syndrome, Kallmann syndrome, anorexia nervosa, andropause, hypothalamic amenorrhea or hyperprolactinemia. In females, the effect of hypogonadism is mediated by estrogen deficiency. It can appear as early menopause (<45 years) or from prolonged premenopausal amenorrhea (>1 year). Bilateral oophorectomy (surgical removal of the ovaries) and premature ovarian failure cause deficient estrogen production. In males, testosterone deficiency is the cause (for example, andropause or after surgical removal of the testes).

Endocrine disorders that can induce bone loss include Cushing's syndrome, hyperparathyroidism, hyperthyroidism, hypothyroidism, diabetes mellitus type 1 and acromegaly, and adrenal insufficiency.

Malnutrition, parenteral nutrition, and malabsorption can lead to osteoporosis. Nutritional and gastrointestinal disorders that can predispose to osteoporosis include undiagnosed and untreated coeliac disease (both symptomatic and asymptomatic people), Crohn's disease, ulcerative colitis, cystic fibrosis, surgery (after gastrectomy, intestinal bypass surgery or bowel resection) and severe liver disease (especially primary biliary cirrhosis).  People with lactose intolerance or milk allergy may develop osteoporosis due to restrictions of calcium-containing foods. Individuals with bulimia can also develop osteoporosis. Those with an otherwise adequate calcium intake can develop osteoporosis due to the inability to absorb calcium and/or vitamin D. Other micronutrients such as vitamin K or vitamin B12 deficiency may also contribute.

What Lab Tests Help to Diagnose Causes of Osteoporosis?

Laboratory investigations in patients with osteoporosis are undertaken to rule out or to detect common causes of osteoporosis in order to treat them. Further targeted investigations may be performed if indicated by clinical presentation, or if the first line investigations are normal but the severity of osteoporosis is unusual for the age and gender. The following first-line measurements may be routinely indicated in the investigation of patients with osteoporosis:

• Serum total calcium, albumin (to calculate albumin adjusted calcium) and phosphorus as part of a CMP panel to detect conditions associated with hypercalcemia such as primary hyperparathyroidism or hypocalcemia and consequent secondary hyperparathyroidism causing bone loss; although albumin adjustment for serum calcium is not universally performed, this practice may be useful to correct total calcium measurements skewed by abnormal albumin levels. Alternatively, ionized calcium measurement gives a more accurate measure of calcium homeostasis.
• Serum creatinine and estimated glomerular filtration rate (GFR) as part of the CMP panel are useful to detect renal failure which can affect bone health. 
• Serum alkaline phosphatase (ALP) as part of a CMP panel. ALP measurement is useful to detect conditions including Paget's disease, metastatic bone disease and osteomalacia, etc. Total ALP is adequate for demonstrating gross increases in bone formation such as those found in most patients with active Paget's disease, osteomalacia, fracture healing or metastatic bone disease, but is not sensitive enough to detect changes in bone remodeling seen in most cases of uncomplicated osteoporosis. Although gamma-glutamyl transpeptidase (GGT) is suggested by some to distinguish an increase in liver ALP from bone ALP, this is neither sensitive nor specific for this purpose. If changes in bone formation need to be determined with sensitivity or distinguished from an increase in total ALP due to liver disease, a specific bone formation marker such as PINP could be measured.
• Vitamin D nutrition should be determined by measuring serum 25-hydroxy vitamin D [25(OH)D]. Although there is controversy about the optimum level of 25(OH)D for bone health; while 50 nmol/L is considered acceptable, others have suggested 75 nmol/L as desirable for optimum bone health [27, 28]. If the higher cut-off is used, then the vast majority of menopausal women (76.8%) would be considered to have sub-optimal vitamin D nutrition.
• Parathyroid Hormone (PTH) measurement would be required if serum calcium is abnormal, to help investigate the cause of the calcium abnormality.
• Ultra-sensitive Estradiol. Low estradiol in men and women has been linked to bone loss.
• Phosphorus. An increased phosphorus with decreased calcium suggests either hypoparathyroidism or renal disease. A decreased phosphorus and an increased calcium suggests hyperparathyroidism or sarcoidosis. When both calcium and phosphorus are decreased diagnostic considerations include malabsorption, vitamin D deficiency and renal tubular acidosis. Increased phosphorus and normal or increased calcium suggests Milk-alkali syndrome or hypervitaminosis D.

Other More Detailed Tests Depending on Specific Conditions (Not included):

 A full examination of blood and erythrocyte sedimentation rate (ESR) would be useful for general health and for inflammatory diseases which often increase bone loss. Serum protein electrophoresis and free light chains in older patients would be useful to exclude multiple myeloma which causes major bone loss. Other secondary causes such as thyrotoxicosis can be excluded with thyroid function tests, and in men hypogonadism is screened with a serum testosterone. In women, the diagnosis of menopause is made clinically and does not warrant estradiol measurement. If Cushing's syndrome is suggested clinically, then screening tests could be performed: 24 hr urine cortisol, midnight salivary cortisol or overnight dexamethasone suppression test. Rarer conditions, if suspected, could be specifically tested; e.g. celiac disease (which is commonly seen in people of European ancestry, but also in parts of Africa, the Middle East and South Asia) with tissue transglutaminase antibody (together with IgA) or systemic mastocytosis with serum tryptase and/or urine methyl histamine. BTMs are not routinely recommended for the assessment of osteoporosis for the reasons stated above. However, if treatment for osteoporosis is to be initiated and monitoring with BTMs is intended, baseline measurement of fasting morning s-CTX and/or s-PINP may be undertaken.

Reference:

Current Recommendations for Laboratory Testing and Use of Bone Turnover Markers in Management of Osteoporosis. Ann Lab Med. 2012 Mar; 32(2): 105–112.

This panel is popular among men who are on testosterone therapy since it offers substantial savings over ordering each of these tests separately. NOTE: Fasting is required for this panel since it includes lipids and CMP.  Tests included are:

Complete Blood Count (CBC) w/ Differential: Hematocrit; hemoglobin; mean corpuscular volume (MCV); mean corpuscular hemoglobin (MCH); mean corpuscular hemoglobin concentration (MCHC); red cell distribution width (RDW); percentage and absolute differential counts; platelet count; red cell count; white blood cell count; immature granulocytes

Comprehensive Metabolic Profile (CMP) ( includes eGFR ): A:G ratio; albumin, serum; alkaline phosphatase, serum; ALT (SGPT); AST (SGOT); bilirubin, total; BUN; BUN:creatinine ratio; calcium, serum; carbon dioxide, total; chloride, serum; creatinine, serum; globulin, total; glucose, serum; potassium, serum; protein, total, serum; sodium, serum; eGFR

Estradiol Ultra-Sensitive, LC/MS (most accurate estradiol test in men)

Testosterone, Free, Equilibrium Ultrafiltration With Total Testosterone, LC/MS

Prolactin

Lipids (Triglycerides, LDL and HDL)

Sex Hormone Binding Globulin (SHBG)

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This PCOS lab test panel includes 19 separate tests and panels at the lowest price in the country:

• Lipid Panel
• CBC
• CMP
• Prolactin
• C-Peptide
• TSH
• Free T4
• Free T3
• Sex Hormone binding Globulin
• DHEA Sulfate
• Estrogen
• FSH
• Insulin Fasting
• A1C
• LH
• Progesterone
• 17-OH Progesterone
• Testosterone, Free, Bioavailable and Total, MS plus SHBG
• Vitamin D

Polycystic literally means "many cysts." In medical terms, it usually refers to a condition called polycystic ovary syndrome (PCOS). PCOS is a hormonal disorder commonly seen in women of childbearing age. The condition is characterized by the presence of multiple fluid-filled cysts in the ovaries. PCOS can cause symptoms like irregular periods, weight gain, acne, and excessive hair growth. Women with PCOS may also experience infertility, diabetes, and heart disease later in life. The exact cause of PCOS is not known, but genetics and insulin resistance are considered contributing factors. PCOS is diagnosed based on symptoms, physical examination, and blood tests. 

Polycystic Ovary Syndrome (PCOS) - Everything You Need to Know

PCOS is one of the most recurrent hormonal disorders among women of all races. Recent medical statistics show that up to 10% of women worldwide suffer from polycystic ovary syndrome. In the United States, the last estimations show that women having PCOS hit 6 million cases.

PCOS is an endocrine condition characterized by metabolic and reproductive abnormalities. This syndrome may cause symptoms and complications for women, from acne, gaining weight, skin tags, anxiety, depression, irregular menstruations to infertility, cancer development, or cardiovascular diseases.

The endocrine system comprises a series of organs and glands that contribute to the production, secrete, and storage hormones. Naturally, women produce androgen hormones (male hormones) in small amounts so the body can work properly.

However, women having PCOS, meaning multiple cysts on the ovary, tend to produce higher amounts of androgen hormones, such as testosterone. This cyst growth leads to various health issues, many of them associated with the reproductive system.

Many women live without being diagnosed until complications or infertility issues arise. It is thought that PCOS may be inherited, and the possibility of developing this syndrome is 50% higher for women having a sister, mother, aunt, or grandmother with this syndrome.

If you are a woman at a reproductive age or want to know more about this so you can create awareness for the women in your life, keep reading and learn how to handle and treat this syndrome.

What are the Symptoms Associated with PCOS?

As previously mentioned, PCOS is a complex disorder, the symptoms associated with it are numerous and can be associated with other minor problems. This is one of the reasons there are still many cases undiagnosed yet, women living with this disorder untreated.

Symptoms of PCOS that a woman may experience:

• Irregular menstruation or its absence
• Abnormal facial and body hair growth
• Prone to acne
• Hair loss
• Infertility
• Weight increase
• Skin tags or dark spots
• Mood-related issues ( depression, anxiety, low self-esteem, poor body image)
• Sleep apnea 
• High Blood Pressure
• Acne on face, chest or neck
• High triglycerides, low HDL cholesterol 

How is PCOS Diagnosed?

If you experience symptoms associated with this syndrome, the best you can do is to see a doctor. If you don't have an endocrinologist or gynecologist, contact your GP to get a referral. As soon as this health disorder is diagnosed, the more you'll reduce the risks of complications.

The usual PCOS diagnosis process includes:

• A clinical examination
• Evaluation of the medical history
• Hormonal tests
• Pelvic ultrasound

What are The Main Hormones that Can Diagnose PCOS?

The most conclusive method to diagnose and monitor PCOS is a hormonal analysis which an endocrinologist usually recommends at different stages of your menstruation. It is paramount to follow your doctor's instructions regarding the timelines of testing.

Here is the most comprehensive panel that indicates the presence of PCOS and at the same help excluding other diagnoses.

• Lipid Panel (LDL/HDL,triglycerides)
• CBC (complete blood count)
• CMP (comprehensive metabolic count)
• Prolactin
• C-Peptide
• TSH
• Free T4
• Free T3
• Sex Hormone binding Globulin
• DHEA Sulfate
• Estrogen
• FSH
• Insulin Fasting
• A1C
• LH
• Progesterone
• 17-OH Progesterone
• Testosterone, Total (LC/MS), and Free (Equilibrium Dialysis)
• Vitamin D

How to Evaluate Your Hormonal Test Values?

The lipid panel consists of:

• LDL (bad cholesterol)
• HDL (good cholesterol)
• Triglyceride (fats in the bloodstream associated with cardiovascular disease)

It is a valuable test type to be considered when trying to diagnose PCOS. It was discovered that 70% of women with PCOS present abnormal lipid values. Low HDL, high triglycerides, or low-density lipoprotein were assessed.

The complete blood count is a standard test to check your overall health condition. This test keeps track of the number of cells found in the blood composition: the platelets, white cells, and blood cells.

Comprehensive Metabolic Panel- As metabolic and reproductive abnormalities characterize PCOS, this test is highly recommended to assess organs such as kidneys, liver, and metabolic function.

It is an efficient way to identify the causes of general symptoms associated with different health conditions, such as fatigue.

The CMP comprises 14 indicators such as glucose, calcium, sodium, potassium, bicarbonate, chloride, blood urea nitrogen, creatinine, albumin, total protein, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), bilirubin.

The results of the tests should be evaluated together with your doctor considering your medical history and medication.

• Prolactin- is on the top of the list when it comes to PCOS and its relation with infertility. Many studies were conducted over the years and despite many beliefs that hyperprolactinemia can show a clear link with infertility, recent observations reject these evaluations.

Nevertheless, for women, prolactin evaluation can help in diagnosing menstruation disorders, suspicions of pituitary tumors, and amenorrhea.

The normal value for a nonpregnant woman is  < 25 ng/mL, while values are between 80-400 ng/mL for a pregnant woman.

• C-Peptide test-measures the C-peptide levels in blood and urine. Usually, this test measures the insulin level. Doctors recommend the test for differentiating type 1 diabetes for type 2 or finding the causes for abnormal blood sugar.

The normal value of this test under fasting is between 0.8 – 3.85 ng/mL, while after meals, 3-9 ng/mL.

• TSH test- used to determine thyroid health and differentiate an overactive thyroid from an underactive one.

TSH levels need to be tested especially during menopause, menstruation, and at the moment of giving birth. These are moments when the TSH levels can be modified.

The normal values for this indicator are between 0.5 -5.0 mIU/L.

• Free T4- also known as thyroxine, is one of the hormones produced by the thyroid. This test is usually performed to evaluate the general thyroid function and identify possible issues as

The normal value for this indicator is between 0.9-2.3 ng/dL.

• Free T3-or triiodothyronine alongside thyroxine is the main hormone released by the thyroid. Their role is to regulate various functions in your body.

The normal value for this indicator is between 2.3–4.2 pg/mL.

• Sex Hormone binding Globulin or (SHBG)- is a protein released by the liver which connects to hormones like testosterone, dihydrotestosterone, and estradiol. SHBG also controls how much of these hormones are delivered to fat tissues.

This hormone test it's one of the most important indicators in the evaluation of PCOS cases.

The normal value for nonpregnant women is between 18-144 nmol/L, while for pregnant women, this may be expected to rise. Too small amounts of this hormone may indicate PCOS.

• DHEA Sulfate- also known as dehydroepiandrosterone sulfate, is a masculine hormone localized in the adrenal gland which helps women produce estrogen, controls blood pressure, and regulates body functions. This test is recommended for women to diagnose ovaries issues, check for causes of hirsutism or investigate menstrual abnormalities.

The normal values for this indicator according to age are displayed below:

• Estrogen- is an essential hormone in developing feminine features, also regulating the menstruation cycles. Testing this hormone can offer a series of information regarding a woman's possibility of getting pregnant, overall health, and menstruation.

Four types of estrogen impact a woman's life over her years: estrone, estradiol, estriol, estetrol. The most active estrogen type is estradiol. Over time, as menopause approaches, the values will be lower and fluctuant.

• Follicle-stimulating hormone (FSH)-is produced in the brain by the pituitary gland, the FSH is a hormone influencing sexual development and the ovarian follicles (eggs).

• Insulin Fasting-this test is performed under fasting conditions to verify insulin resistance.

The normal value for this indicator is generally accepted between 2-20 mIU/mL.

• A1C-or hemoglobin A1C is a test that can offer information about sugar levels in your blood for the last few months. It is an excellent indicator in evaluating diabetes cases. Your doctor may recommend this in case of PCOS complications.

• LH- the luteinizing hormone has an important role in the development of sexual function and also in the regulation of the menstrual cycle. Increased values of this indicator can suggest a primary ovarian failure. This analysis is required in cases of infertility, menstrual abnormalities, or delayed puberty for girls.

• Progesterone- a hormone produced by the ovaries, is a vital hormone when looking to get pregnant. This is an indicator that has to be checked at a specific stage of your menstrual phase, at the indicator of your medical provider.

The normal value for this indicator should be between 5-20 ng/mL.

• 17-OH Progesterone - hormone produced by the adrenal glands, usually recommended when a woman is suspected of congenital adrenal hyperplasia disorder.

The normal values are considered to be less than 200 ng/dL.

• Testosterone, Total (LC/MS), and Free (Equilibrium Dialysis)-these are key tests when it comes to PCOS, recommended for women suspected of increases in androgen hormones.

Normal testosterone levels for women between 18- 70 years old are considered to be between 0.5 to 2.4 nmol/L.

• Vitamin D- vital for bone development, skin, teeth, or immune system also has a powerful impact on balancing hormones such as testosterone, SHBG, insulin for women with PCOS.

The normal values for an adult woman are between 20-80 ng/mL.

What Are The Risks Associated with PCOS?

Leaving PCOS untreated may quickly degenerate to other serious conditions that can potentially damage your quality of life. Numerous women are facing:

• Insulin resistance leads to type 2 diabetes
• Obesity
• Heart attack
• Stroke
• Non-alcoholic fatty liver disease
• Other women are at risk of developing endometrial cancer because of irregular menstruations
• Depression, anxiety

Can PCOS be Treated?

PCOS can be treated by having the proper treatment and some lifestyle changes. The treatment should be developed by a specialist like an endocrinologist or gynecologist. Also, it is recommended to ask for help from a dietitian and a physiotherapist.

Some lifestyle changes that you can start today involve:

• Eat healthier, more greens and fruits
• Limit fried, processed foods
• Obtain and maintain the optimal weight
• Start exercising (pilates, yoga, light aerobic)

The Bottom Line

Hormones influence our overall health, appearance, and mental state. Prevention is the key to maintaining a healthy life. Doctors recommend at least a visit a year to a gynecologist and an endocrinologist.

Make sure you are one step ahead of any issue and order your PCOS hormonal panel to give you a full-length evaluation of your health. Go to DiscountedLabs.com and order your test today from the comfort of your home.

Post Cycle Therapy (PCT) Panel: A Comprehensive Guide to Hormonal Health Post-Steroid Cycle

What Is the Post-PCT Panel?

The Post-PCT Panel is a specialized set of tests aimed at assessing the health and recovery status of your Hypothalamic-Pituitary-Testicular Axis (HPTA) following a steroid cycle. Whether you've relied on natural normalization or used Post Cycle Therapy (PCT), this panel provides the essential metrics for understanding your body's hormonal balance.

Why Is Post Cycle Therapy (PCT) Important?

Post Cycle Therapy is a regimen undertaken after completing a cycle of performance-enhancing drugs like anabolic steroids. While these substances can lead to impressive muscle gains, they often come with a downside—negative effects on your testosterone levels and overall physical well-being. Here’s the science behind it:

1. The Steroid Impact: Anabolic steroids introduce a high level of artificial testosterone into your system. When you cease usage, your natural testosterone production takes a hit, leading to various physical symptoms.

2. The Recovery Phase: Your body will try to naturally reboot its testosterone production. However, reaching a hormonal balance could be a long, drawn-out process.

3. Role of PCT: Post Cycle Therapy aims to expedite your return to hormonal balance by stimulating natural testosterone production. However, the effectiveness of PCT is still under scientific scrutiny.

Why Do You Need the Post-PCT Panel?

The Post-PCT Panel is crucial for evaluating:

1. Testosterone Balance: Supplemental testosterone can inhibit your body's natural production, impacting the levels of Luteinizing Hormone (LH).

2. Sperm Quality: Inhibition of LH also affects levels of Follicle Stimulating Hormone (FSH), which is vital for sperm production.

For optimum accuracy, it’s advised to take this panel at least four weeks post-PCT and preferably in a fasting state in the morning.

What Tests Are Included?

The Post-PCT Panel offers a wide range of tests:

• Ultra Sensitive Estradiol (E2) by LC/MS: Precision in estradiol levels for men.

• Total and Free Testosterone LC/MS: No upper limit restrictions.

• Luteinizing Hormone (LH): Key to testosterone production.

• Follicle Stimulating Hormone (FSH): Vital for sperm production.

• CBC - Complete Blood Count: Includes hematocrit.

• CMP - Comprehensive Metabolic Panel: Covers liver and kidney functions, glucose levels, and electrolytes. Note: Fasting is required for an accurate glucose test.

At DiscountedLabs.com, our Post-PCT Panel leverages state-of-the-art technology and a comprehensive array of tests to give you a full view of your hormonal health post-steroid cycle. With our guidance, you can effectively monitor your recovery and understand the impact of performance-enhancing drugs on your system. Take control of your health—schedule your Post-PCT Panel today!

References

• Pereira et al. "Anabolic Steroids Among Resistance Training Practitioners." PLoS One, 2019.

• McBride, J. A., & Coward, R. M. "Recovery of Spermatogenesis Following Testosterone Replacement Therapy or Anabolic-Androgenic Steroid Use." Asian J Androl, 2016.

• AlShareef, S. et al. "Anabolic Steroid Use Disorder." StatPearls, 2022.

• Delu, A. et al. "CC Improved Testosterone and Sperm Concentration in Hypogonadal Males." Systems Biology in Reproductive Medicine, 2020.

• de Ronde, W. "Unjustified Prescribing of CMA and PCT, Lack of Awareness!" Journal of Clinical Endocrinology, 2020.

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Suggested Reading: Testosterone Replacement Blood Test Targets

This pre-op surgery lab test panel includes:

Complete Blood Count (CBC):

A CBC also helps your health professional diagnose conditions like infection, anemia, and several other disorders. Test includes: WBC, RBC, Hemoglobin, Hematocrit, MCV, MCH, MCHC, RDW, Platelets, Neutrophils, Lymphs, Monocytes, Eos, Basos, Neutrophils (Absolute), Lymphs (Absolute), Monocytes(Absolute), Eos (Absolute), Basos (Absolute), Immature Granulocytes, Immature Grans (Abs)

Comprehensive Metabolic Panel (CMP)

This panel includes:

The Serum Glucose test is how we diagnose diabetes. If the glucose is 126 on a fasting blood draw, meaning the blood was drawn first thing in the morning after an overnight fast, before you ate any breakfast, then you have diabetes. Now, that's assuming that when we repeat the test, we get the same results. It needs to be abnormal more than once.

The Uric Acid test is how we diagnose gout.

The BUN, Blood Urea Nitrogen, can be abnormal in kidney disease, dehydration, and heart failure, as well as malnutrition and liver disease.

The Serum Creatinine is a measure of kidney function. The BUN to Creatinine ratio can give information on the possible cause of the kidney dysfunction, say heart failure or dehydration or decreased kidney blood flow.

The Serum Sodium can be increased in dehydration. The Serum Sodium can be decreased in diuretic therapy and in the syndrome of inappropriate antidiuretic hormone abbreviated, SIADH. The Serum Potassium can be increased in adrenal insufficiency and acute renal failure, as well as with an inappropriate combination of medicines. Potassium could be decreased in primary aldosteronism, diuretic therapy, and renal tubular acidosis.

The Serum Chloride can be increased in dehydration and renal tubular acidosis, and it can be decreased in congestive heart failure and in primary aldosteronism. The Carbon Dioxide can be increased in primary pulmonary disease, such as severe COPD and in primary aldosteronism. It can be decreased in metabolic acidosis, such as occurs with the diabetic ketoacidosis.

The Serum Calcium can be increased in an endocrine disease called primary hyperthyroidism. It can also be increased in malignancy. However, most of the time, when a person has a high Serum Calcium found unexpectedly, it's simply due to hyperparathyroidism, which can be treated. Now, we can also have a decreased Serum Calcium in hypoparathyroidism and in vitamin D deficiency.

The Serum Phosphorus can be increased in acute or chronic renal failure and decreased in malabsorption and vitamin D deficiency.

The total Serum Protein can be increased in multiple myeloma and sarcoidosis, and it can be decreased in chronic glomerulonephritis, which is a type of chronic renal disease.

The Serum Albumin can be decreased in liver disease, cirrhosis, and in nephrotic syndrome. The total Globulin and the Albumin to Globulin ratio can be increased or decreased due to a number of causes.

The total Bilirubin can be increased in hepatitis, hemolytic anemia, and in blockage of the bile ducts, either the bile ducts within the liver or within the bile duct that drains the gallbladder and the liver. That's what we mean when we say cholestasis or biliary obstruction. The direct Bilirubin is increased in the same things as the total Bilirubin, but the ratio of direct to total gives us clues as to the causes. One of the most common causes of a mildly elevated total Bilirubin found on a routine CMP is a syndrome called Gilbert's disease. Although it's called a disease, it's common, and it doesn't cause any liver damage or any health damage.

The Alkaline Phosphatase can be increased in bone disease and liver disease and decreased in malnutrition and celiac disease.

The AST, and ALT are often called liver enzyme tests. They don't measure liver function, but rather give evidence of liver damage, but they can also be elevated in damage to other parts of the body. They can be increased in liver disease, muscle disease, pancreatitis, and excessive exercise.

Prothrombin with INR and Partial Thromboplastin Times (PTT)

These tests are usually ordered for patients prior to surgery to ensure normal clotting ability.  The PT and PTT Blood Tests are useful in the diagnosis of excessive, unexplained bleeding in patients who are not taking blood-thinning medications. These bleeding disorders include conditions such as nosebleeds, bruising, heavy menstrual periods, blood in the stool and/or urine, and bleeding gums, among others. 

This hormone panel can be used to diagnose primary or secondary hypogonadism (testosterone deficiency), prostate health prior to initiating testosterone replacement therapy. It also includes information about hematocrit (red blood cell volume), and liver and kidney function.

 Panel includes:

 - LH and FSH (Pituitary hormones that stimulate testicular cells that can help diagnose primary (testicular) or secondary hypogonadism)

  - Total and free testosterone (LC/MS assay.  No upper limit restriction)

- Prostatic specific antigen (PSA) (TRT is contraindicated for PSA equal or above 4.0)

 - Estradiol (Ultra-sensitive. LC/MS assay)

 - Lipids (LDL, HDL, Triglycerides)

 - Comprehensive Metabolic Panel (CMP) (Glucose, electrolytes,  liver/kidney functions)

 - Comprehensive Blood Count (CBC) (Immune cells, red  blood cells, hemoglobin, hematocrit)

You can add DHEA,Thyroid Panel ,Prolactin ,and DHT test for a more comprehensive picture of your hormonal health.

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Suggested Reading: Testosterone Replacement Blood Test Targets

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1-     Go to the "Find a Location" page to find the closest lab location. 

2-     Go to "Choose a Test" and add your selection (s) in the shopping cart.

3-     If you have a discount coupon code, add it to your cart.

4-     Pay using a credit card.

5-     You will receive a lab requisition by email during business hours.

6-     Print lab request form attached to the lab request form email (PDF file).

7-     Take that form to the closest lab with a picture ID. Get your blood drawn.  

8-     Your results will be ready within 5-7 business days (depending on the test). 

Prolactin is a hormone produced in the pituitary gland that is known for supporting lactation in women but also has many other functions on immune response, myelin coating on nerves, and enhances LH receptors on testicular Leydig cells so that testosterone can be produced. 

What is Prolactin?

Prolactin is a hormone produced in the pituitary gland that is known for supporting lactation in women but also has many other functions on immune response, myelin coating on nerves, and enhances LH receptors on testicular Leydig cells so that testosterone can be produced. 

Prolactin levels peak during REM sleep and in the early morning. Levels can rise after exercise, meals, sexual intercourse, minor surgical procedures, or epileptic seizures.

In both men and women, the pituitary gland creates the hormone prolactin. In women, it is principally in charge of breastfeeding, some types of breast tissue development, and milk production [3]. Prolactin levels, however, can significantly affect sexual performance in men. The impact of elevated prolactin levels on male sexual performance as well as the ideal prolactin range will be discussed in this article.

Prolactin levels in men are commonly thought to be best between 2 and 18 ng/mL. It is crucial to remember that typical ranges can change based on the facility doing the test. Prolactin levels can change during the day and with specific activities, such exercise, and are typically higher in women than in males [3].

A blood test to determine a man's prolactin levels may be prescribed by his doctor if he is exhibiting signs of elevated prolactin levels, such as sexual dysfunction. More testing could be required to identify the underlying reason if the levels are discovered to be high. Treatment can be required in some situations to lower prolactin levels and enhance sexual function. This may entail taking drugs to reduce prolactin production or having any tumors that may be the reason for the elevated levels removed surgically [2].

In conclusion, men's sexual function can be significantly impacted by excessive prolactin levels. The production of testosterone and other hormones that are crucial for sustaining sexual desire and function can be affected when prolactin levels are too high. Although normal levels can differ depending on the laboratory doing the test, the ideal range for prolactin in men is normally between 2 and 18 ng/mL. A blood test to evaluate prolactin levels and identify the underlying cause may be prescribed by a doctor if a man exhibits signs of excessive prolactin levels.

Normal Prolactin Ranges:

During pregnancy and postpartum lactation, serum prolactin can increase 10- to 20-fold. Exercise, stress, and sleep also cause transient increases in prolactin levels. Consistently elevated serum prolactin levels (>30 ng/mL)indicate hyperprolactinemia in the absence of pregnancy and postpartum lactation. Pituitary adenomas, hypothalamic disease, breast or chest wall stimulation, renal failure, or hypothyroidism can cause prolactin hypersecretion. Several drugs, including many antidepressants, are also common causes of abnormally elevated prolactin levels. Hyperprolactinemia often results in galactorrhea, amenorrhea, infertility in females, and impotence and hypogonadism in males. Renal failure, hypothyroidism, and prolactin-secreting pituitary adenomas are common causes of abnormally elevated prolactin levels.

High Prolactin Consequences

Women are more likely than men to have hyperprolactinemia, or high prolactin levels. However it can arise from a variety of factors in both sexes. Pituitary tumors, prescription drugs, and other underlying medical disorders are a few factors that can contribute to high prolactin levels in men [4]. Men who have high levels of prolactin may have a variety of sexual issues, such as decreased sperm production, erectile dysfunction, and libido loss [5].

Low testosterone production is one of the main ways that excessive prolactin levels have an impact on men's sexual performance. Men's ability to have sexual desire and function is maintained by the hormone testosterone. Prolactin can interfere with the creation of testosterone when levels are too high, which decreases sexual desire and affects erectile function [3].

High prolactin levels can impact the levels of other hormones involved in sexual function in addition to lowering testosterone production. For instance, excessive levels of prolactin can inhibit the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), both of which are crucial for preserving testosterone synthesis and sperm quality in men [3].

High prolactin can decrease testosterone and cause sexual dysfunction.

Low Prolactin Consequences:

However, low prolactin blood levels have also been found to be linked to sexual dysfunction and other issues.  Since prolactin seems involved in immune response and heart muscle integrity, keeping healthy levels is essential.

Prolactinomas are classified as microadenomas (<10 mm) and macroadenomas (>10 mm). Substantial elevation in prolactin (>50 ng/mL) usually indicates a pituitary tumor. Very high levels of prolactin are associated with larger tumors. The finding of a substantial elevation in blood levels of prolactin association with a pituitary lesion more significant than 10 mm by radiographic analysis supports the diagnosis of a macroprolactinoma.

Modest levels of prolactin elevation (25–50 ng/mL) may be associated with several diagnoses. Primary hypothyroidism and chronic renal disease are associated with elevations in prolactin, probably because of altered metabolism or clearance of prolactin. All other causes of hyperprolactinemia should be excluded before a tumor is considered.

Some medications can increase prolactin blood levels in men, as shown in this table (From Ther Clin Risk Manag. 2007 Oct; 3(5): 929–951.)

When to Get the Prolactin Lab Test:

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Suggested Reading: Testosterone Replacement Blood Test Targets

Doctors usually require this test before surgeries to ensure someone can coagulate properly during an operation.

Prothrombin with INR and Partial Thromboplastin Times - PT/INR: A screening test for abnormalities of coagulation factors that are involved in the extrinsic pathway. Also used to monitor the effects of Warfarin therapy and to study patients with hereditary and acquired clotting disorders.

The PT and PTT Blood Tests are helpful in the diagnosis of excessive, unexplained bleeding in patients who are not taking blood-thinning medications. These bleeding disorders include nosebleeds, bruising, heavy menstrual periods, blood in the stool and/or urine, and bleeding gums. The tests are sometimes ordered for patients before surgery to ensure normal clotting ability.

A “prolonged” result means a blood clot takes longer than normal to form. There are a variety of causes for this, including coagulation/clotting factor deficiency/dysfunction, vitamin K deficiency, liver disease, inhibition by specific antibodies, and others. The general interpretation of PT & PTT Blood Test results can be summarized as follows:

• PT prolonged, PTT prolonged: Dysfunctional or insufficient coagulation factor I, II, V, or X; acute disseminated intravascular coagulation (DIC) (abnormal activation of coagulation factors); severe liver disease.

• PT prolonged, PTT normal: Dysfunctional or insufficient coagulation factor VII, chronic low-grade DIC, insufficient vitamin K, liver disease, warfarin (anticoagulant) therapy.

• PT normal, PTT prolonged: Dysfunctional or insufficient coagulation factor VIII, IX, or XI; severe von Willebrand disease (hereditary bleeding disorder); the presence of lupus anticoagulant.

• PT normal, PTT normal or slightly prolonged: Normal clotting ability, mild deficiencies in other coagulation factors, a mild form of von Willebrand disease.

Are you familiar with the terms INR and PTT? If not, don't worry. This essential guide will walk you through everything you need to know about mastering Prothrombin. We've got you covered, from understanding why these tests are necessary and when to get them done to the preparation required and the interpretation of the test results. We'll also answer common questions like whether you can do this test at home, what food and medications can affect the results, and more. Additionally, we'll provide information on related tests and sources for further reading. Stay tuned as we delve into this important aspect of healthcare and show you how to buy an affordable INR and PTT test on DiscountedLabs.com.

Prothrombin with INR and Partial Thromboplastin Times (PTT): At a Glance

Measurements of blood clotting ability rely on tests like prothrombin time (PT) and international normalized ratio (INR). These tests are particularly important for patients taking anticoagulant medications, such as warfarin. Monitoring PT and INR values helps determine the appropriate anticoagulant dosage and evaluate the risk of bleeding or clotting. Another vital test, the partial thromboplastin time (PTT), assesses a different aspect of the clotting process. Healthcare professionals involved in managing patients with coagulation disorders or undergoing anticoagulant therapy must understand and interpret PT, INR, and PTT results effectively.

Why Get Tested for Prothrombin Time with INR?

Regular testing for PT and INR is crucial for individuals on blood-thinning medications like warfarin. It helps monitor blood clotting, assess medication effectiveness, and reduce the risk of complications. Especially important for those with conditions like atrial fibrillation or deep vein thrombosis. Testing also gives healthcare professionals a specimen to analyze and make informed decisions regarding the patient's treatment plan.

When To Get Tested?

If you are taking anticoagulant medication or have a bleeding disorder, getting tested for INR and PTT is important. Your healthcare provider will determine the frequency based on your condition and treatment plan. Following their instructions and scheduling regular testing will help ensure proper management of your prothrombin levels.

Is a Sample Required?

Yes, a blood sample is necessary for both INR and PTT tests. The sample is typically taken from the arm using a needle prick and sent to a lab for analysis. It's crucial to follow any fasting or medication guidelines your healthcare provider gives before the test.

What Test Preparation is Needed?

Test preparation for INR and PTT blood tests may differ based on your medical condition and medications. Preparations may include fasting or avoiding specific medications that affect clotting factors. Follow your healthcare provider's instructions and inform them of any medication, supplement, or herbal remedy usage to ensure accurate test results.

What is Being Tested?

The tests being conducted are the INR (International Normalized Ratio) and PTT (Partial Thromboplastin Time) tests, which are used to monitor blood clotting. The INR test measures how your blood clotting time compares to a standardized control sample, while the PTT test measures your blood's response to specific substances. These tests help identify clotting disorders and ensure that anticoagulant medication is at the appropriate dosage.

Common Questions About Prothrombin Time with INR

The Prothrombin with INR and Partial Thromboplastin Times (PTT) blood tests are crucial in monitoring blood clotting and detecting clotting disorders. These tests offer insights into the coagulation process and help healthcare providers assess the effectiveness of anticoagulant therapy. It is essential to understand the purpose of these tests, their conduct, and the implications of abnormal results. Patients often have queries regarding the influence of food and medications on PT and INR test results. Additionally, they may question the need for consistent testing times and the reasons behind varying PT/INR results despite stable medication dosages.

How is the test used?

The prothrombin time (PT) test measures how long blood takes to clot, mainly to monitor the effectiveness of anticoagulant medications. It's also used to diagnose bleeding disorders and liver disease. Results are reported as an international normalized ratio (INR) for standardization.

When is it ordered?

PT and INR tests are typically ordered to monitor blood-thinning medications, investigate unexplained bleeding or clotting disorders, assess bleeding risk before surgeries, and evaluate blood clotting function in specific medical conditions like liver disease or vitamin K deficiency.

What does the test result mean?

The test result is measured using the INR and PTT. A higher INR suggests longer clotting time, while a longer PTT may indicate a bleeding disorder. Consulting a healthcare professional is crucial for interpreting the results and deciding on suitable treatment or monitoring.

Interpretation of PT and PTT in Patients with a Bleeding or Clotting Syndrome

PT (Prothrombin Time) and PTT (Partial Thromboplastin Time) are vital laboratory tests used to assess the clotting ability of a patient's blood in cases of bleeding or clotting disorders. These tests measure the duration it takes for blood to clot; abnormal results can indicate potential issues with clotting factors. In patients presenting with bleeding disorders, an extended PT or PTT may suggest a deficiency in essential clotting factors like Factor II (prothrombin), Factor V, or Factor VII. Conversely, a shortened PT or PTT may indicate an excess of clotting factors in patients with clotting disorders, as observed in Factor V Leiden mutation or lupus anticoagulant. Accurate interpretation of PT and PTT results in conjunction with clinical symptoms and other laboratory tests is necessary to establish the underlying cause of bleeding or clotting abnormalities.

What food and medications can affect PT and INR results?

Certain foods rich in vitamin K, like leafy greens and broccoli, can impact PT and INR results. Medications such as antibiotics and anti-inflammatory drugs can also affect these levels. It's crucial to inform your healthcare provider about any dietary changes or medications you're taking, as they may need to adjust dosages or suggest dietary modifications based on your PT and INR results.

I am being treated with warfarin (Coumadin®). Should I avoid eating foods that are rich in vitamin K, and will limiting these foods cause an increased risk of vitamin K deficiency?

If you are being treated with warfarin (Coumadin®), it is crucial to maintain a consistent intake of vitamin K-rich foods. Avoiding or drastically limiting these foods can lead to an increased risk of vitamin K deficiency and may affect the effectiveness of warfarin. Instead, strive for a balanced diet and consult your healthcare provider to manage your warfarin therapy properly.

Should I have a PTT done at the same time of day?

It is generally advised to have a prothrombin time (PT) test done at the same time of day for consistency. This helps in identifying any patterns or fluctuations in blood clotting levels. However, follow specific instructions from your healthcare provider regarding timing. Consult with them for personalized guidance on when to schedule your PT test.

My PT/INR results vary sometimes, yet my doctor doesn’t change my prescription. Why?

Your PT/INR results can fluctuate due to various factors like diet, medication changes, or illness. Your doctor may not alter your prescription if the variations are within an acceptable range and take into account your overall health and medical history. However, it's crucial to communicate any concerns or questions you have about your PT/INR results with your doctor.

Related Tests

The evaluation of blood clotting ability involves several tests, such as the Prothrombin Time (PT) and Partial Thromboplastin Time (PTT). PT measures the time it takes for blood to clot and is used to monitor patients receiving anticoagulant therapy. PTT, on the other hand, helps evaluate the effectiveness of heparin therapy. Hence, both tests are crucial in assessing a patient's coagulation status and determining the appropriate dosage of anticoagulant medication. Understanding the purpose and interpretation of these tests is indispensable for healthcare professionals working in hematology or coagulation laboratories.

Sources

The Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) tests are essential in assessing a patient's blood clotting ability. The International Normalized Ratio (INR) test, commonly used to monitor patients on anticoagulant therapy, and the PTT test, used to evaluate the effectiveness of heparin therapy, are significant in managing patients with bleeding disorders or at risk of blood clots. Understanding the normal range of INR and PTT values is crucial for interpreting test results and making informed treatment decisions.

How to Buy an Affordable Prothrombin Time with INR Test on DiscountedLabs.com

Looking to purchase a high-quality and affordable INR and PTT test? Look no further than DiscountedLabs.com, where we understand the importance of monitoring your prothrombin levels and assessing your blood clotting ability. With our user-friendly website and extensive range of tests, finding the right option for your needs has never been easier. Our tests are accurate and reliable, providing you with the peace of mind you deserve. Once you receive your results, our team of experts is here to help you interpret and understand them thoroughly. Don't compromise your health - choose DiscountedLabs.com for all your INR and PTT test requirements.

Conclusion

Understanding your Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) levels is crucial for managing your health. These tests help ensure that your blood is clotting properly and can detect any potential bleeding or clotting disorders. You and your healthcare provider can make informed decisions about your treatment plan by monitoring these levels. If you're curious about how to interpret test results, the importance of timing, or if you can do this test at home, check out our comprehensive guide. Take control of your health today - get tested and understand what those results mean for you. To buy an affordable INR and PTT test, visit DiscountedLabs.com now.

QuantiFERON-TB Gold Plus (IGRA Test): The Gold Standard

Tuberculosis (TB) is a serious infectious disease that affects millions of people worldwide. Accurate and timely diagnosis is essential to preventing the spread of TB and ensuring that patients receive the appropriate treatment. In recent years, QuantiFERON-TB Gold Plus has emerged as a leading alternative to traditional TB tests such as the tuberculin skin test (TST). The QuantiFERON-TB Gold Plus test is a blood-based assay that detects the presence of TB-specific antigens in the blood. It offers several advantages over traditional TB tests, including higher sensitivity and specificity, a faster turnaround time, and no cross-reactivity with the Bacillus Calmette-Guérin (BCG) vaccine. In this blog post, we will explore how QuantiFERON-TB Gold Plus works, its advantages over other TB tests, and its practical aspects. We will also address common misconceptions about QuantiFERON-TB Gold Plus and debunk some myths surrounding it. Finally, we will discuss whether QuantiFERON-TB Gold Plus is the future of TB diagnosis.

Commercially Available IGRAs for M tuberculosis

The quantiferon tb gold plus test is one of the commercially available interferon-gamma release assays (IGRAs) used for the diagnosis of tuberculosis. This test is based on the principle that T-cells in the blood release interferon-gamma when exposed to specific antigens derived from Mycobacterium tuberculosis. The quantiferon tb gold plus test has higher sensitivity and specificity than the traditional tuberculin skin test and provides results within 24 hours. This makes it a valuable tool for screening individuals who are at high risk of developing tuberculosis, such as healthcare workers, immigrants, and prisoners.

Understanding the Basics of QuantiFERON-TB Gold Plus

QuantiFERON-TB Gold Plus is an advanced tuberculosis (TB) test that gauges the immune response to TB antigens. It relies on interferon-gamma release assays (IGRAs), which detect the release of interferon-gamma by T cells when exposed to TB infection. This whole blood assay necessitates a small blood sample for analysis. One of the key advantages of QuantiFERON-TB Gold Plus is its ability to provide quantitative results by measuring the amount of interferon-gamma produced in response to TB antigens. Moreover, this test offers a quicker alternative to traditional TB tests, as results are available within 24 hours. By understanding the basics of QuantiFERON-TB Gold Plus, healthcare professionals can gain valuable insights into the immune response to Mycobacterium tuberculosis infection and effectively diagnose both active and latent tuberculosis infections.

The Science Behind the QuantiFERON-TB Gold Plus Test

The QuantiFERON-TB Gold Plus test utilizes TB-specific peptide antigens, such as ESAT-6 and CFP-10, to stimulate the immune response. These antigens are mixed with the patient's blood sample and then incubated for a specific amount of time. During this incubation period, if the patient has been exposed to TB, their T cells will release interferon-gamma in response to the antigens. The released interferon-gamma is then measured using an enzyme-linked immunosorbent assay (ELISA). Qft-git is a commonly used abbreviation for the QuantiFERON-TB Gold Plus test.

By measuring the amount of interferon-gamma, the QuantiFERON-TB Gold Plus test can determine whether there is a latent TB infection or active TB disease present. This test provides a more accurate and specific diagnosis compared to other traditional TB tests. The QuantiFERON-TB Gold Plus test can provide results within 24 hours, making it a faster alternative for quantitative measurements. A positive QFT result plays a crucial role in accurately diagnosing TB infections and aiding in treatment decisions.

How Does QuantiFERON-TB Gold Plus Work?

QuantiFERON-TB Gold Plus works by measuring the immune response to TB antigens using a blood sample. The sample is divided into three tubes: a nil control, TB antigen tube, and a positive control. Using ELISA technology, it is possible to measure the amount of interferon-gamma that T cells release in response to TB antigens. The nil value in the nil control tube is used to determine the baseline level of interferon-gamma in the absence of TB antigens.

Interpreting a QuantiFERON-TB Gold Plus Test Result

Interpreting a QuantiFERON-TB Gold Plus Test Result:

A positive test result from the QuantiFERON-TB Gold Plus indicates the presence of either a latent TB infection or active TB disease. On the other hand, a negative result suggests the absence of a tuberculosis infection. However, it is important to note that an indeterminate result might occur due to issues with blood collection, handling, or laboratory procedures. Therefore, it is crucial for a healthcare professional to interpret the test results in conjunction with the patient's medical history and other diagnostic information. In cases where the result is positive or indeterminate, additional tests such as chest X-rays or sputum cultures should be conducted to further evaluate the condition. This comprehensive approach ensures accurate diagnosis and appropriate treatment decisions.

Advantages of QuantiFERON-TB Gold Plus over Other TB Tests

QuantiFERON-TB Gold Plus offers several advantages over other TB tests. Firstly, it has higher specificity compared to the tuberculin skin test (TST) in populations vaccinated with Bacillus Calmette-Guérin (BCG). This means that QuantiFERON-TB Gold Plus is less likely to produce false-positive results in individuals who have received the BCG vaccine. Additionally, QuantiFERON-TB Gold Plus eliminates the need for a second patient visit as the blood sample can be collected and processed at a convenient time. This saves both time and effort for patients and healthcare providers.

Furthermore, QuantiFERON-TB Gold Plus is unaffected by prior BCG vaccination, lowering the possibility of false-positive results. The test also shows improved specificity as it does not cross-react with most non-tuberculosis mycobacteria. This ensures a more accurate detection of TB infections. Another advantage of QuantiFERON-TB Gold Plus is that it provides quantitative results, allowing for a more objective interpretation. These quantitative results provide additional information for healthcare professionals to assess the severity of the infection and guide appropriate treatment decisions. Overall, QuantiFERON-TB Gold Plus offers significant advantages over other TB tests, providing more accurate and convenient testing options for the detection of TB infection.

Comparison of Sensitivity and Specificity between QuantiFERON-TB Gold Plus and Other TB Tests

QuantiFERON-TB Gold Plus has been found to have comparable sensitivity to the TST in detecting latent TB infection. However, it offers a higher specificity, especially in populations that have been vaccinated with BCG. When compared to other interferon-gamma release assays (IGRAs), QuantiFERON-TB Gold Plus has demonstrated improved sensitivity and specificity. The test exhibits better agreement with the presence of TB disease compared to the TST. Additionally, QuantiFERON-TB Gold Plus provides greater reliability and lower rates of false-positive results. Its higher specificity reduces the chances of false-positive results, making it a valuable tool in accurately identifying individuals with TB infection, including those co-infected with HIV. This is particularly important in regions where BCG vaccination is prevalent or in healthcare settings where distinguishing between latent TB infection and active tuberculosis disease is crucial. QuantiFERON-TB Gold Plus offers an advanced diagnostic option for detecting and monitoring Mycobacterium tuberculosis infection, aligning with the World Health Organization's strategy of targeting latent tuberculosis infection to achieve tuberculosis control globally.

Detection of Active and Latent TB Infection

QuantiFERON-TB Gold Plus can effectively detect both active and latent TB infections. A positive result indicates either a current active TB infection or a previous exposure to TB resulting in latent infection. However, it is important to note that the presence of active TB disease should always be confirmed using additional diagnostic tests such as sputum cultures and chest X-rays. This ensures an accurate diagnosis and appropriate treatment.

In the case of latent TB infection, if left untreated, there is a risk of it progressing to active TB disease. This highlights the importance of identifying and treating individuals with LTBI-latent TB infection. QuantiFERON-TB Gold Plus plays a crucial role in identifying individuals at risk of developing active TB. By using interferon-gamma release assays (IGRAs) like QuantiFERON-TB Gold Plus, healthcare providers can effectively assess the prevalence of latent TB infection and take necessary measures to prevent the progression to active tuberculosis disease. The use of QuantiFERON-TB Gold Plus has been validated in several studies published in the Journal of Clinical Microbiology (J Clin Microbiol).

Understanding Indeterminate Responses in QuantiFERON-TB Gold Plus

Indeterminate responses in QuantiFERON-TB Gold Plus may occur due to issues with blood collection, handling, or laboratory procedures. Certain medical conditions, such as immunosuppression, can also lead to indeterminate results. An indeterminate result means that the test could not provide a definitive positive or negative outcome. Individuals with indeterminate results should be retested to obtain a valid interpretation. Repeat testing should follow proper blood collection and processing protocols. It is important to address these indeterminate responses to ensure accurate and reliable results from the QuantiFERON-TB Gold Plus test. By understanding the factors that can contribute to an indeterminate result, healthcare providers can take the necessary steps to minimize these occurrences and ensure accurate diagnosis and monitoring of tuberculosis infections.

Does Prior Vaccination or Testing Affect a QuantiFERON-TB Gold Plus Result?

When compared to the TST, QuantiFERON-TB Gold Plus offers higher specificity because it is unaffected by prior BCG vaccination. Prior testing with QuantiFERON-TB Gold or QuantiFERON-TB Gold In-Tube does not affect the interpretation of QuantiFERON-TB Gold Plus results. A positive result indicates an immune response to TB antigens, regardless of previous testing or vaccination history.

Addressing Common Misconceptions about QuantiFERON-TB Gold Plus

QuantiFERON-TB Gold Plus is not a standalone diagnostic tool for active TB disease. Instead, it aids in identifying individuals with latent TB infection. To ensure accurate interpretation, healthcare professionals should assess the test results alongside other clinical and laboratory findings, as well as consider the patient's overall health care needs. It's important to note that QuantiFERON-TB Gold Plus does not replace the need for contact tracing and other infection control measures. False-positive results may occur in individuals with non-tuberculous mycobacterial infections or autoimmune conditions. Therefore, it's crucial to perform the test following proper collection and processing protocols, with trained healthcare professionals handling the specimen. By addressing these common misconceptions, we can enhance understanding and promote the appropriate utilization of QuantiFERON-TB Gold Plus as a valuable complementary tool in the fight against tuberculosis.

Practical Aspects of QuantiFERON-TB Gold Plus

The practical aspects of QuantiFERON-TB Gold Plus make it a convenient and efficient option for TB testing. The blood collection process is easy and straightforward, requiring minimal handling and incubation time. Results can be obtained within 24 hours, providing a quick turnaround time for healthcare professionals. QuantiFERON-TB Gold Plus can be performed in any standard laboratory setting, making it accessible to healthcare facilities worldwide. It offers accurate and reliable results compared to other TB tests, ensuring confidence in its diagnostic capabilities. By incorporating NLP terms such as Mycobacterium tuberculosis, latent tuberculosis infection, and interferon gamma release assays, the test aligns well with international guidelines, including those set by the World Health Organization. With its practical advantages, QuantiFERON-TB Gold Plus is an invaluable tool in the detection and monitoring of TB infections.

How Reliable is QuantiFERON-TB Gold Plus in Monitoring TB Therapy?

QuantiFERON-TB Gold Plus is highly reliable in monitoring TB therapy. By quantifying the immune response to TB antigens, it can detect both active and latent TB infection. This test also helps monitor treatment response and identify treatment failure. When used alongside clinical evaluation, it provides accurate quantitative results for easy tracking of progress.

Can QuantiFERON-TB Gold Plus be Used for Children and Immune-compromised Individuals?

QuantiFERON-TB Gold Plus can be used for children and individuals with compromised immune systems. It provides accurate results without requiring a strong T-cell response, making it helpful in diagnosing TB in populations with weaker immune responses. Additionally, it is less affected by previous BCG vaccination compared to traditional tests and provides reliable results in immunosuppressed individuals.

Understanding Conversion and Reversion in QuantiFERON-TB Gold Plus

Conversion and reversion are important concepts to understand when it comes to the QuantiFERON-TB Gold Plus test. Conversion refers to the indication of recent tuberculosis (TB) infection or reactivation. It shows that someone has been exposed to the bacterium Mycobacterium tuberculosis, and their immune system has responded by releasing interferon-gamma in response to specific antigens. Reversion, on the other hand, indicates a decrease in the immune response over time. It can be a result of waning immunity or successful treatment of the TB infection.

Monitoring conversions and reversions is crucial as it helps healthcare professionals assess disease progression. By tracking these changes, they can identify individuals who may be at risk of developing active TB. Additionally, monitoring conversions and reversions assists in evaluating the effectiveness of TB prevention strategies, such as vaccination programs.

The QuantiFERON-TB Gold Plus test provides quantitative results, measured in international units (IU), making it easier to track progress over time. It is a reliable tool for assessing TB infection, both active and latent, and can be used in conjunction with clinical evaluation for a more accurate diagnosis.

In conclusion, understanding conversion and reversion in QuantiFERON-TB Gold Plus is essential for assessing disease progression, identifying individuals at risk of active TB, and determining the effectiveness of TB prevention strategies. This test provides valuable insights into the immune response to TB and plays a significant role in the diagnosis and management of this infectious disease.

How Does QFT-Plus Compare with Traditional TB Blood Test Methods in Low-Risk Populations?

Compared to the traditional TST, QFT-Plus offers higher specificity and lower chances of false-positive results. It does not cross-react with BCG vaccination or most non-tuberculosis mycobacteria. In low-risk populations, QFT-Plus provides higher sensitivity, reduces the need for repeat testing, and offers faster turnaround time.

What are the Sources of Variability in QuantiFERON-TB Gold Plus Test Results?

QuantiFERON-TB Gold Plus test results can be different because of biological factors like age and immune status, pre-analytical factors like sample collection and shipping, technical factors like assay performance and lab procedures, and the effects of circadian rhythms and stress on interferon-gamma levels. Standardization and quality control measures help minimize variability.

Debunking Myths about QuantiFERON-TB Gold Plus

There are several myths surrounding the QuantiFERON-TB Gold Plus test that need to be addressed. Firstly, there is a misconception that the QFT-Plus is expensive compared to other TB tests. However, this is not true, as the cost of the QFT-Plus test is comparable to other diagnostic options available.

Another myth is that the QFT-Plus is not as accurate as the tuberculin skin test (TST). In reality, the QFT-Plus offers higher sensitivity and specificity in detecting active and latent tuberculosis infections compared to the TST.

Some people believe that the QFT-Plus cannot differentiate between active and latent TB. This is incorrect, as the test measures the release of interferon-gamma in response to specific antigens of Mycobacterium tuberculosis, making it capable of distinguishing between active and latent TB infections.

It is also mistakenly believed that specialized training is required for interpreting QFT-Plus results. However, the test provides clear positive and negative readings, making it easy to interpret without requiring specialized training.

Lastly, some think that the QFT-Plus is not suitable for high-burden TB settings. On the other hand, organizations like the World Health Organization have extensively validated and recommended the QFT-Plus for use in high-burden TB settings.

In conclusion, these myths about QuantiFERON-TB Gold Plus have been debunked with evidence and facts, highlighting the accuracy, effectiveness, and suitability of the test in various scenarios.

What Makes QuantiFERON-TB Gold Plus a Preferred Choice for TB Testing?

With higher specificity, QuantiFERON-TB Gold Plus is less affected by BCG vaccination and non-tuberculosis mycobacteria. It eliminates the risk of false-positive results due to the booster phenomenon. The test provides objective and quantitative results for easy interpretation, while ensuring minimal patient discomfort compared to the TST. Additionally, it is suitable for individuals with previous positive TST or indeterminate results.

Is QuantiFERON-TB Gold Plus the Future of TB Diagnosis?

Advancements in TB diagnosis and screening have led to a growing preference for QuantiFERON-TB Gold Plus (QFT-Plus) over traditional tests. Ongoing research aims to further improve the performance and accessibility of QFT-Plus, potentially replacing the tuberculin skin test as the standard TB screening method. Healthcare providers are increasingly adopting and accepting QFT-Plus as the future of TB diagnosis.

How to Buy an Affordable Quantiferon TB Gold Plus Test from DiscountedLabs.com

To purchase an affordable Quantiferon TB Gold Plus test from DiscountedLabs.com, start by browsing their website to explore the available options. Take into consideration your specific needs and select the test package that best suits you. Once you have made your selection, follow the instructions provided on the website to conveniently place your order online. After completing the order process, you will receive a lab requisition form either via email or as a download from the website. This form is essential for your test procedure. Next, visit a participating lab, where a healthcare professional will collect a blood sample from you. Rest assured that the process is quick and efficient. Finally, you can expect to receive your test results in a timely manner, allowing you to gain valuable insights into your health status.

Frequently Asked Questions

What makes QFT-Plus the world’s #1 TB blood test?

QFT-Plus stands out as the top TB blood test due to its higher sensitivity and specificity compared to other tests. With just one blood draw, it delivers results within 24 hours. Unlike other tests, QFT-Plus is unaffected by prior BCG vaccination, lowering the likelihood of false positives. It can detect latent TB infection, crucial for early intervention.

How accurate is the Quantiferon TB Gold Plus test compared to other tuberculosis tests?

The Quantiferon TB Gold Plus test is highly accurate, with a sensitivity of 94-98% and a specificity of 97–99%. Unlike other tuberculosis tests, it has lower rates of false positives due to previous BCG vaccination or exposure to non-tuberculosis mycobacteria. Additionally, it is more convenient as it only requires one blood draw and does not require a follow-up visit for reading results.

Does prior TST affect a QFT-Plus result?

Prior TST (tuberculin skin test) can affect a QFT-Plus (Quantiferon TB Gold Plus) result. False-positive QFT-Plus results may occur in individuals who have had a prior positive TST or BCG vaccination. False-negative results may occur in individuals who have recently had a TST or are immunosuppressed. It is important to discuss any prior TST or BCG vaccinations with your healthcare provider before getting a QFT-Plus test to ensure accurate results.

How long does it take to get results from a Quantiferon TB Gold Plus test?

The results from a Quantiferon TB Gold Plus test can be obtained within 24 hours, making it faster than other TB tests like a skin test or sputum culture. Additionally, this test is known for its accuracy compared to traditional TB tests. Results can be obtained from the healthcare provider who ordered the test.

Can Quantiferon TB Gold Plus be used for monitoring tuberculosis treatment progress?

Monitoring the progress of tuberculosis treatment requires more than just the Quantiferon TB Gold Plus test. While this test is useful for diagnosing tuberculosis infection, it cannot be used as a sole indicator of treatment progress. Other tests, such as sputum cultures and chest x-rays, are typically employed to monitor treatment effectiveness. Consult with a healthcare professional for the best approach to monitoring tuberculosis treatment.

Can an IGRAs TB Blood Test be used for children?

IGRAs, like the QuantiFERON TB Gold Plus test, can be used for children. In fact, IGRAs are recommended by the Centers for Disease Control and Prevention (CDC) as a preferred method of testing for tuberculosis infection in children who are 5 years or older. This is because IGRAs have been shown to be more accurate than the traditional tuberculin skin test (TST) and do not require a follow-up visit to interpret results. However, it is important to consult with your child's healthcare provider to determine if IGRA testing is appropriate for their individual situation.

Prospective Comparison of QFT-GIT and T-SPOT TB Assays for Diagnosis of Active Tuberculosis

The QFT-GIT (Quantiferon TB Gold Plus) assay is a highly sensitive test that has been developed for the diagnosis of active tuberculosis. The assay measures the production of interferon-gamma by T cells in response to specific antigens from Mycobacterium tuberculosis. A recent study compared the performance of QFT-GIT and T-SPOT.TB assays for the diagnosis of active tuberculosis. The study found that QFT-GIT had a higher sensitivity than T-SPOT.TB, making it a more effective tool for diagnosing active tuberculosis. The QFT-GIT assay is a valuable tool for healthcare professionals who are looking to accurately diagnose and treat patients with tuberculosis.

Conclusion

In conclusion, QuantiFERON-TB Gold Plus is a highly accurate and reliable test for detecting tuberculosis infection. Its advanced technology and methodology make it superior to traditional TB tests such as the tuberculin skin test. With its high sensitivity and specificity, QuantiFERON-TB Gold Plus provides more accurate results, reducing the chances of false positives and false negatives. Additionally, it offers the advantage of detecting both active and latent TB infections. This test is particularly beneficial for individuals who have received the BCG vaccine or those with compromised immune systems. DiscountedLabs.com offers affordable QuantiFERON-TB Gold Plus tests, making it accessible to everyone. Take control of your health and get tested today.

These renal panel labs include blood and urine tests commonly used by physicians to determine kidney dysfunction: Urinalysis, Comprehensive Metabolic Panel (CMP), Cystatin C and eGFR.

A renal function panel is a crucial set of tests to assess the overall health and efficiency of your kidneys. The tests of a renal function panel are necessary to monitor kidney performance, which is vital for maintaining blood pressure levels, eliminating waste from the bloodstream, and keeping electrolyte balance in check. In this blog post, we will delve into various aspects of a renal function panel.

We will begin by discussing urinalysis as part of the renal function panel and its importance in detecting early signs of kidney dysfunction as well as identifying urinary tract infections. Next, we'll explore the Comprehensive Metabolic Panel (CMP) and its key components that help evaluate kidney health.

Additionally, we will introduce Cystatin C, an alternative marker for assessing kidney function with certain advantages over traditional creatinine-based eGFR calculation methods. Furthermore, you'll learn about estimated glomerular filtration rate (eGFR) calculations and interpretation, along with factors affecting these values.

At the end, we'll show you how to get ready for a renal panel test and explain your results so that you can make wise choices about potential future actions concerning your kidney wellbeing.

Table of Contents:

• Urinalysis in Renal Function Panel
  • Detecting Early Signs of Kidney Dysfunction Through Urinalysis
  • The Role Of Urinalysis In Identifying Urinary Tract Infections
• Comprehensive Metabolic Panel (CMP)
  • Key Components and Significance within the Renal Function Panel
  • Understanding How CMP Results Relate to Overall Health
  • Cystatin C - An Alternative Marker for Kidney Function Assessment
• Estimated Glomerular Filtration Rate (eGFR) Calculation & Interpretation
  • Importance of eGFR values in evaluating renal function
  • Factors affecting eGFR calculations
• Renal Panel Test Process & Results Interpretation
  • Preparing for a Renal Panel Test
  • Understanding Your Results and Potential Next Steps
• FAQs in Relation to Renal Function Panel
  • What is the Renal Function Panel?
  • What is the difference between a CMP and a Renal Function Panel?
• Conclusion

Urinalysis in Renal Function Panel

Urinalysis is a crucial component of the renal function panel, which evaluates kidney function by measuring various substances present in urine. It can detect abnormalities such as high levels of glucose or protein, which may indicate kidney disease or other underlying medical conditions. This test provides valuable information about hydration status, urinary tract infections, and even some types of cancer.

Detecting Early Signs of Kidney Dysfunction Through Urinalysis

The early detection of kidney dysfunction is essential for preventing further damage and maintaining overall health. Urinalysis helps identify any abnormal findings that could be indicative of potential issues with your kidneys. For example, elevated levels of protein in the urine (proteinuria) may suggest a problem with the glomeruli, tiny filters within your kidneys responsible for removing waste products from your bloodstream.

The Role Of Urinalysis In Identifying Urinary Tract Infections

Urinary tract infections (UTIs) are common bacterial infections that affect millions each year. A urinalysis can detect bacteria, white blood cells, and red blood cells in a urine sample—all indicative of an infection within the urinary system—thereby helping to diagnose UTIs quickly for prompt treatment and prevention of complications. Prompt diagnosis and treatment are vital to preventing complications like kidney damage or recurrent infections.

Urinalysis is a significant element of the renal function assessment, as it can provide clues to possible kidney difficulties in their early stages. Moving on, a comprehensive metabolic panel (CMP) also plays a key role in identifying potential issues with your kidneys and understanding how CMP results relate to your overall health.

Comprehensive Metabolic Panel (CMP)

The Comprehensive Metabolic Panel (CMP) is a vital part of the renal function panel, as it consists of 14 different blood tests that provide valuable insights into your overall metabolic health. These measurements help assess specific organ functions and detect potential electrolyte imbalances related to kidney dysfunction.

Key Components and Significance within the Renal Function Panel

• Electrolytes: The CMP measures levels of sodium, potassium, chloride, and bicarbonate in your blood. Abnormal levels can indicate problems with fluid balance or kidney function.
• Total Protein and Albumin: These proteins are essential for maintaining fluid balance in your body. Low albumin levels may suggest kidney disease or malnutrition.
• Liver Enzymes: Alanine transaminase (ALT), alkaline phosphatase (ALP), and aspartate transaminase (AST) are enzymes that help evaluate liver function - an important factor when assessing overall metabolic health.
• Blood Glucose Levels: High glucose levels could be indicative of diabetes - a condition known to affect kidney health negatively over time if left untreated.

Understanding How CMP Results Relate to Overall Health

An abnormal result on any component within the CMP may warrant further investigation by a healthcare professional. For example, elevated liver enzymes might prompt additional testing for liver diseases such as hepatitis or cirrhosis. In cases where abnormalities point towards potential kidney dysfunction, like high electrolyte concentrations or low protein values - a more comprehensive renal function panel, including tests like urinalysis and eGFR calculations, may be recommended to assess kidney health more accurately.

The CMP can be a valuable asset in gauging an individual's general wellbeing, as it gives significant insights regarding kidney performance. Moving on to cystatin C, this alternative marker offers advantages over traditional creatinine-based eGFR calculation methods and has many clinical applications and implications.

Cystatin C - An Alternative Marker for Kidney Function Assessment

Cystatin C serves as an alternative marker for assessing the glomerular filtration rate, which essentially reflects how efficiently the kidneys filter waste products from the bloodstream. Compared to creatinine-based eGFR calculations, which heavily rely on muscle mass for accuracy, cystatin C offers more precise insights into actual kidney performance, regardless of individual body composition differences. This makes it a valuable tool for assessing kidney function.

Advantages over traditional creatinine-based eGFR calculation methods

• Provides better accuracy in patients with varying muscle mass, such as the elderly and those suffering from muscle-wasting diseases.
• Less influenced by factors like diet, medications, or supplements like creatine that can affect creatinine levels.
• Potentially allows for earlier detection of kidney dysfunction compared to creatinine-based measurements (source).

Clinical applications and implications

Combining cystatin C with creatinine can improve diagnostic accuracy and enable more precise monitoring of kidney health, potentially leading to earlier detection of dysfunction and improved treatment plans. This increased precision allows physicians to better monitor kidney health, detect early signs of dysfunction, and adjust treatment plans accordingly. Additionally, research suggests that elevated cystatin C levels may be associated with a higher risk of cardiovascular events (source). Therefore, monitoring this biomarker could provide valuable information not only about renal function but also about overall cardiovascular health.

Cystatin C has been proven to be a reliable and accurate marker for assessing kidney function, making it an excellent alternative to the traditional creatinine-based eGFR calculation methods. By understanding how the estimated glomerular filtration rate (eGFR) is calculated and interpreted, we can better understand our renal health status and make informed decisions about any necessary treatments or lifestyle changes.

Estimated Glomerular Filtration Rate (eGFR) Calculation & Interpretation

The estimated glomerular filtration rate (eGFR) is an essential calculation derived from either creatinine or cystatin C levels in the blood. This value estimates how much blood passes through the glomeruli, tiny filters within your kidneys responsible for removing waste products and excess fluids - per minute. A low eGFR may indicate decreased kidney function, while a high one could signify better filtration capabilities.

Importance of eGFR values in evaluating renal function

• eGFR helps identify early signs of kidney dysfunction, allowing for timely intervention and treatment.
• It plays a crucial role in monitoring chronic kidney disease progression and response to therapy.
• eGFR is used to determine appropriate medication dosages based on individual kidney function, reducing potential side effects or toxicity risks.

Factors affecting eGFR calculations

Different factors can influence the accuracy of eGFR calculations. These include:

1. Muscle mass: Creatinine-based eGFR relies heavily on muscle mass; thus, it might be less accurate among elderly individuals or those with significant muscle loss due to illness. In such cases, cystatin C-based calculations are more reliable.
2. Race: Certain ethnic groups have different average creatinine levels compared to others; therefore, race-specific adjustments are often applied when calculating eGFR using creatinine measurements (source).
3. Age and sex: Age-related changes in kidney function, as well as differences between men and women, can affect eGFR values. These factors are typically accounted for when calculating the estimated filtration rate.

It is important to understand the importance of eGFR values and the factors that affect them in order to properly assess renal function. Moving on, it is equally important to be aware of what a renal panel test entails and how best to interpret the results for any next steps taken.

Renal Panel Test Process & Results Interpretation

A renal panel test is an essential tool for monitoring kidney function or as a follow-up if you have already had an abnormal kidney panel test result. To ensure accurate results, patients need to fast for 8–12 hours before their blood draw appointment. Once completed, the renal panel test typically provides results within just a few business days and includes separate line items detailing each component of the examination.

Preparing for a Renal Panel Test

• Fasting: Refrain from eating or drinking anything except water for 8-12 hours prior to your appointment.
• Maintain Hydration: Drink plenty of water leading up to your appointment, as dehydration can affect your results.
• Informed Consent: Inform your healthcare provider about any medications or supplements you are taking that may interfere with the accuracy of the tests.

Understanding Your Results and Potential Next Steps

Your renal panel test report will provide detailed information on each component measured in the examination. Some key aspects include urinalysis findings, CMP values such as electrolyte levels and liver enzymes, cystatin C concentrations, and eGFR calculations. It's crucial to discuss these results with a qualified healthcare professional who can help interpret them in context with other factors like age, gender, race, and medical history. Based on this analysis, they might recommend further testing or suggest appropriate lifestyle changes such as diet modifications or exercise routines, medication adjustments, or referrals to specialists if necessary.

FAQs in Relation to Renal Function Panel

What is the Renal Function Panel?

The Renal Function Panel is a set of blood and urine tests that assess kidney health by measuring various markers, such as electrolytes, glucose, protein levels, and liver enzymes. These tests help detect early signs of kidney dysfunction and monitor existing conditions.

What is the difference between a CMP and a Renal Function Panel?

A Comprehensive Metabolic Panel (CMP) evaluates both liver and kidney functions, along with other metabolic processes, through 14 different blood measurements. The Renal Function Panel specifically focuses on assessing kidney health using fewer tests like urinalysis, Cystatin C measurement, eGFR calculation, and sodium-potassium balance evaluation.

Conclusion

Overall, the renal function panel is a comprehensive test that evaluates various aspects of kidney health. It includes urinalysis, CMP, cystatin C, and eGFR measurements. Healthcare professionals use this test to detect abnormalities in glucose and protein levels, assess hydration status, and identify urinary tract infections. Monitoring these values over time can help detect early signs of kidney dysfunction.

If you are interested in getting a renal function panel test done for yourself or a loved one, consider using Discounted Labs' discounted panels. With affordable pricing and easy-to-understand result interpretation provided by licensed physicians, taking control of your health has never been easier.

Discounted Labs caters to individuals who want to take charge of their health without breaking the bank. Their renal function panel test is just one of many tests they offer at a discounted price. By using Discounted Labs, you can save money while still receiving high-quality healthcare services.

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This panel contains testosterone and its downstream metabolites: Estradiol and DHT. All three hormones are measured using Liquid Chromatography/Mass Spectrometry (LC/MS), the most accurate assay for hormones. No interactions with supplements like biotin are present.

Around 0.4% of testosterone aromatizes to estradiol in fat mass, testicles, and liver. Around 10% of testosterone converts to DHT via the alpha reductase enzyme. This enzyme is produced in many tissues in both males and females, in the reproductive tract, testes and ovaries, skin, seminal vesicles, prostate, epididymis and many organs, including the nervous system.

Testosterone, Total, LC/MS and Free (Equilibrium Ultrafiltration)

This panel includes total testosterone measured by the most accurate method (liquid chromatography/mass spectrometry LC/MS), free testosterone percent by equilibrium dialysis/ultrafiltration, and free testosterone calculated from percent free T. It is adequate for men who expect high T levels and women (LC/MS is accurate for high and low T levels also).

Total Testosterone:

–   Liquid chromatography tandem mass spectrometry (LC/MS/MS)- No upper limit

–   Analytical sensitivity: 1.0 ng/dL

–   Analytical specificity: no cross-reactivity with other steroid compounds

–   Analytical Measurement Range: 1.0 ng/dL to 2,000 ng/dL

Free and Total Testosterone:

–   Percent free: equilibrium dialysis/ultrafiltration

–   Free: calculated based on total and percent free testosterone

Ultrasensitive Estradiol Test

This test may take up to 7 business days to obtain results. Estradiol is produced by the body via the aromatization of testosterone in fat tissue, liver, and testicles. Estradiol is involved in bone health, cognitive function, sex drive, and body composition in both men and women. Depending on lifestyle factors, liver Issues, medications, body fat mass, and genetics, some people may have higher estradiol conversions from testosterone.

The commonly used estradiol test may overestimate estradiol. That test uses immunoassay technology that cannot differentiate C-Reactive Protein (involved in inflammation) from estradiol, so it reads the combination of the two as estradiol. This overestimation can lead to excessive use of an aromatase inhibitor that can result in low estradiol which can cause several health issues. This ultrasensitive estradiol test is based on liquid chromatography/mass spectrometry (LC/MS), an assay technology that does not have that limitation.

DHT Test

Dihydrotestosterone (DHT) is synthesized from testosterone in the prostate gland, testes, hair follicles, and adrenal glands by 5-alpha reductase. Dihydrotestosterone exerts its action similar to testosterone, which binds to and activates androgen receptors. Dihydrotestosterone is responsible for the formation of male primary sex characteristics and most male secondary sex characteristics during puberty, such as muscular growth, facial and body hair growth, and deepening of the voice.

Excess DHT has been associated with hair loss, prostate volume increase, and acne in men with a genetic predisposition to those issues. Blocking or decreasing DHT to low levels may cause sexual dysfunction. More information on DHT in men.

Testosterone, Free, Equilibrium Ultrafiltration With Total Testosterone, LC/MS. No Upper or Lower Limit. Free T is calculated ​by first getting the percent free T by equilibrium dialysis/ultrafiltration and then calculating the actual free T value based on total and percent free testosterone.

Hematocrit is the portion of total blood volume made up of red blood cells. Testosterone replacement therapy can increase hematocrit. Hematocrit over 52 may increase blood thickness and cardiovascular risks.

Estradiol (ULtra Sensitive LC/MS) is produced by the body via the aromatization of testosterone in fat tissue, liver, and testicles. Estradiol is involved in bone health, cognitive function, sex drive, and body composition in both men and women. Depending on lifestyle factors, liver issues, medications, body fat mass, and genetics, some people may have higher estradiol conversions from testosterone. The use of a ultra sensitive, LC/MS assay for serum E2 measurement in males is preferred over direct immunoassays because of its greater sensitivity and lesser interference by other steroids. In males, estradiol is present at low concentrations in blood, but it is extraordinarily high in semen.  Estradiol plays an important function in sperm maturation and is essential for normal spermatogenesis and sperm motility. It is also essential for healthy bone density, body composition, lipids, and brain function. However, E2 excess in the presence of low testosterone and genetic factors can cause gynecomastia in some men.

Prolactin is secreted by the pituitary gland. There are two major functions of prolactin: to induce milk production and to develop nerve cells. Higher levels of prolactin have been associated with tumors involving the lungs, the pituitary gland, and the kidneys. A prolactin test is sometimes used by doctors to evaluate sexual dysfunction of unknown cause in both men and women. Drugs, supplements and certain diseases like pituitary adenomas may disrupt normal prolactin blood levels. These include hypothyroidism, antiepileptics, antidepressants, estrogen, opiates, diuretics, certain growth hormone-releasing peptides and arginine.

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This economical lab test panel includes the four tests more frequently ordered by men on TRT:

• Total Testosterone, Liquid Chromatography/ Mass Spectrometry (The most accurate testosterone test with no lower or upper limit).
• Free Testosterone, Equilibrium Dialysis (The gold standard for free testosterone testing)
• Ultrasensitive Estradiol (The most accurate estradiol test  also done using liquid chromatography/ mass spectrometry with no interference from inflammatory markers and supplements like biotin)
• Hematocrit (Portion of red blood cells in blood. High hematocrit is the main side effect of testosterone. It is important to determine if a blood donation is needed).

NOTE: Results for hormone tests that use liquid chromatography can take 5-7 business days.

HOW DOES DISCOUNTEDLABS.COM WORK?

1-     Go to the "Find a Location" page to make sure we serve your state and that there is a Quest Diagnostics location near you. 

2-     Go to "Choose a Test" and add your selection (s) in the shopping cart. You can also save money by buying bundled lab test panels.

3-     If you have a discount coupon code, add it to your cart.

4-     If you don't have an account with us, you will be asked to create one by adding your name, address, gender, and date of birth.

5-     Place your order by using a credit card.

6-     You will receive three emails: an order confirmation & detailed instructions within minutes about how to download your lab requisition form to take to the lab near you.

7-     Print the lab requisition form (PDF file). 

8-     Take that form to the Quest Diagnostics lab near you . You can walk in but we suggest that you make an appointment to cut down on potential waiting (instructions on how to do so are in our "Find a Location" page). Get your blood drawn at the lab.  

9-    Your results will be ready within 3-7 business days (Depending on the test. Sensitive hormone tests done by liquid chromatography/mass spectrometry LC/MS take 5-7 business days). You will received them by email as soon as they come in.

This lab test panel is good for men and women.

This panel includes:

• Testosterone, Total, LC/MS and Testosterone, Free (Equilibrium Dialysis)
• Luteinizing Hormone (LH)
• Follicle Stimulating Hormone (FSH)

This panel is useful in determining the health of the hypothalamic-pituitary-testicular axis (HPTA) and whether a man has primary or secondary hypogonadism. Only for men and women not currently on testosterone therapy. If you are on TRT, LH and FSH will be zero or very low, so this panel would not be helpful.

Testosterone, LH, FSH - Everything you Need to Know

The examination of FSH, LH, and testosterone is helpful in the treatment of male infertility.

The primary regulators of germ cell development are:

• FSH (follicle-stimulating hormone)
• LH (the luteinizing hormone)
• Testosterone

This panel is helpful in determining primary or secondary hypogonadism disorder. It is also recommended for assessing the health of the hypothalamic-pituitary-testicular axis, also known as HPTA.

Tests will be worth considering only for persons who do not undertake TRT, LH, or FSH therapy at the time.

What is Testosterone?

Testosterone is the most essential male hormone, with a significant role in developing a man's reproductive system. Still, it plays a vital role in many other areas of health, both for men and women.

Testosterone is produced in the testicles and ovaries. Testosterone is also significantly reduced in the adrenal glands (located above the kidneys) in both sexes.

The brain and pituitary gland (a small endocrine gland at the base of the brain that secretes hormones) control testosterone production.

The hypothalamus transmits to the pituitary gland how much hormone to produce, and the pituitary gland sends the message to the testicles or ovaries. Further on, testosterone, like other hormones, enters the bloodstream, reaching other organs.

Why Should You Test Your Testosterone?

For men, testing may be recommended for:

• Clinical suspicion of androgenic deficiency (primary hypogonadism, hypopituitarism, Klinefelter's syndrome, Down syndrome, delayed puberty, sexual impotence, infertility, estrogen treatment, liver cirrhosis)
• Clinical suspicion of androgenic excess: adrenal cortical tumors, early puberty

In women, testing may be recommended for:

• Hirsutism, anovulation, amenorrhea, or virilization (possible causes: polycystic ovary syndrome, virilizing ovarian tumors, adrenal cortical tumors, or congenital adrenal hyperplasia)

What is LH?

Together with FSH (follicle-stimulating hormone), LH belongs to the gonadotropic family. The secretion of FSH and LH is pulsatile and is controlled by the intermittent release of gonadotropin-releasing hormone (GnRH) from the hypothalamus.

LH and FSH regulate and stimulate the growth and functioning of the gonads (ovaries and testicles). The two hormones are produced by the gonadotropic cells of the anterior pituitary gland. They reach the blood and from there to the gonads.

In the ovaries, gonadotropins stimulate the growth and maturation of follicles, the formation and evolution of the corpus luteum, and the synthesis and secretion of estrogen and progesterone.

In men, LH stimulates the activity of Leydig testicular cells, which is why it is also called the interstitial cell-stimulating hormone.

The highest level of LH occurs in the middle of the menstrual cycle, inducing ovulation and the formation of the corpus luteum (whose main secretion product is progesterone). In Leydig cells in the LH testes, it stimulates testosterone production and controls the normal maturation of sperm.

Why Should You Test Your LH levels?

For men, LH testing may be recommended for:

• Elucidation of dysfunctions of the hypothalamic-pituitary-gonadal axis (mainly for the differential diagnosis between primary testicular failure and testicular stimulation deficiency)
• Ectopic secretion of LH by a neoplasm

In women, testing may be recommended for:

• Elucidation of dysfunctions of the hypothalamic-pituitary-gonadal axis (mainly for the differential diagnosis between primary ovarian failure and ovarian stimulation deficiency)
• Polycystic ovary disease (Stein-Leventhal syndrome)
• Clarification of the causes of amenorrhea
• Congenital diseases with chromosomal aberrations Turner syndrome)
• Diagnosis and treatment of infertility
• Ectopic secretion of LH by a neoplasm
• Menopausal syndrome

What is FSH?

Follicular hormone (FSH) is an essential component of the body's reproductive function, being responsible for the development of ovarian follicles in women and the production of sperm in men.

In women, ovarian follicles produce estrogen and progesterone and help maintain menstrual cycles.

FSH is required for the start of spermatogenesis and the maturation of spermatozoa.

Higher levels of FSH in infertile men are thought to be a reliable sign of germinal epithelium damage. High FSH blood levels have been linked to sperm production issues like azoospermia and severe oligozoospermia.

In men, FSH is a component of the development of the testicular function, contributing to the production of semen. FSH analysis measures the levels of FSH in the blood.

Your doctor may recommend this test to find the underlying cause of the symptoms that affect your reproductive system.

Why Should You Test Your FSH Levels?

In women, FSH testing may be recommended for:

• Assessment of fertility problems
• Evaluation of irregular menstrual cycles
• Diagnosis of pituitary gland disorders or ovarian diseases

In men, FSH testing may be recommended for:

• Assessment of the reduced amount of semen
• Establish a diagnosis of hypogonadism or gonadal insufficiency
• Establishing testicular dysfunction

What is the HPTA?

HPTA stands for hypothalamic-pituitary-testicular axis. It is composed of:

• GnRH - hypothalamus gonadotropin-releasing hormone
• FSH
• LH
• Gonadal steroids

The hypothalamic-pituitary-testicular (HPT) axis is primarily responsible for male reproduction, development, and maintenance of male sexual traits.

The male reproductive hormonal cascade is regulated by GnRH, which is the key regulator. Through a closed-loop feedback system, the HPT axis maintains a dynamic equilibrium of serum levels of reproductive hormones.

Following the progress made in the field of reproduction, it results that the main circuit hypothalamus-pituitary-testicular is not independent but is integrated into the endocrine system, in which the general balance is maintained by functional coordination between the glands.

The functional disorganization, at any level, of this general circuit will have transitory or definitive implications on the genital sphere of the male and, more precisely, on his fertility.

What is Hypogonadism?

Hypogonadism in men is a congenital or acquired syndrome in which the testicles fail to produce physiological levels of testosterone and sperm because there is a dysfunction of the hypothalamic-pituitary-testicular axis.

Hypogonadism is classified into two main categories: primary and secondary. There is no universal cause for this. These two testosterone deficiency types may be either inherited or caused by a particular event in life, like infections or injuries. Sometimes, these disorders may happen together at once.

The hormonal and reproductive function of the testicles (gonads) is regulated through interactions among the hypothalamus, the pituitary gland, and the gonads (commonly known as the hypothalamic-pituitary-gonadal axis [HPGA] or HPTA). The three glands communicate through a cascade of hormones and a self-regulating feedback loop that controls the generation of each hormone. The release of gonadotropin-releasing hormone (GnRH) from the hypothalamus regulates the secretion of other hormones (gonadotropins) that influence the testicles by way of the pituitary. GnRH controls the anterior pituitary secretion of two gonadotropin hormones- luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Luteinizing hormone regulates the production and secretion of testosterone through the Leydig cells of the testes, while FSH stimulates the production of sperm.

When someone is diagnosed with low testosterone blood levels, this is known as “hypogonadism” There are several types of hypogonadism:

• Primary hypogonadism is a hypergonadotropic condition (higher than normal levels of LH and FSH). This occurs when the testicles fail to produce sufficient testosterone levels to suppress the production of LH and FSH. As a result, LH and FSH levels are elevated while testosterone levels are decreased. The pituitary gland tries to increase testosterone to no avail, even after increasing LH and FSH.

• Secondary hypogonadism results from hypothalamic or pituitary dysfunction. It is characterized by disruption of central components of the HPGA, resulting in decreased levels of GnRH, LH, or FSH. In this type of hypogonadism, low levels of LH do not allow for the proper stimulation of testosterone production by the testes.

• Mixed hypogonadism results from a combination of primary and secondary causes. The most common cause of mixed hypogonadism is late-onset hypogonadism, which occurs with aging. This is associated with osteoporosis, decreased lean body mass, reduced cognition, fatigue, and impaired libido and erectile function. Other causes of mixed hypogonadism include alcoholism, diseases (such as uremia, liver failure, AIDS, and sickle cell disease), street drugs/alcohol, and medications like corticosteroid steroids used for inflammatory conditions. It should be noted that high cortisol levels (hypercortisolism), resulting from either the use of anti-inflammatory steroids or physical causes, could lead to hypogonadism.

What Are the  Symptoms of Low Testosterone (Hypogonadism)?

Clinical symptoms depend on the age at which the hormone deficiency sets in androgens.

If hypogonadism develops before puberty, for example, as part of a condition genetic, the man will have:

• Eunuchoid proportions,
• Delayed secondary sexual characters
• High voice

Symptoms are less specific if hypogonadism develops after puberty and is characterized, for example, by:

• Reduced sexual function
• Infertility
• Decreased energy
• Depression
• Mild anemia
• Decreased muscle volume and strength
• Increased adipose tissue and BMI

Order Your Testosterone Tests Now

As hormones are sometimes unpredictable and may affect us more than we can see with the bare eye, it is recommended to have at least once a year a check-up. If any of the symptoms above are present, it is recommended to visit a doctor anytime soon. For testosterone, LH, FSH testing, and many others, go to DiscountedLabs.com and take your test in the proximity of your home.

Click for more information about how to choose the best testosterone test for you.

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How to Increase Testosterone

This is the most cost effective testosterone test panel that takes the least amount of time to perform and that includes 5 important tests: 1- Total testosterone, 2- Calculated free testosterone, 3- Calculated bioavailable (unbound) testosterone, 4- Sex hormone binding globulin (SHBG), and albumin. Testosterone upper limit under 1,500 ng/dL  and lower limit of 250 ng/dL (ECLIA, immunoassay).

This panel is accurate for most men using or not using TRT .

There are several types of testosterone tests that can be used to measure the levels of testosterone in a person's body. These tests include:

1. Total testosterone test: This test measures the total amount of testosterone in the blood. It is the most common type of testosterone test and is used to diagnose testosterone deficiency or excess.

2. Free testosterone test: This test measures the amount of testosterone that is not bound to proteins in the blood. It is used to diagnose testosterone deficiency or excess and to monitor testosterone therapy.

3. Bioavailable testosterone test: This test measures the amount of testosterone that is available to the body's cells. It is used to diagnose testosterone deficiency or excess and to monitor testosterone therapy.

For men expecting very high testosterone blood levels over 1,500 ng/dL or low testosterone levels under 250 ng/dL, the testosterone LC/MS panel  or the Testosterone Total LC/MS & Free T by Equilibrium Analysis, Biovailable T and SHBG panel is more appropiate but takes a few more days to perform.

Women can order this other testosterone panel since their T levels may be lower, which requires liquid chromatography/mass spectrometry for accuracy.

Important Note on Test Accuracy for Low Testosterone Levels:

Due to the diminished accuracy of immunoassay at total testosterone levels below 250 ng/dL, calculations of the Free and Bioavailable Testosterone are not accurate and will not be reported.

Lab Test Collection Instructions

Testosterone, Total, Males (Adult), Immunoassay: Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

Note: The lab requisition form will list this test as 

Testosterone, Free, Bioavailable and Total, Males (Adult)

without including SHBG.  No worries!  The results will include SHBG since it is needed to calculate bioavailable testosterone.

FREE BONUS: EBook: Beyond Testosterone

Suggested Reading: Testosterone Replacement Blood Test Targets

At DiscountedLabs.com, we understand the importance of hormone balance and its impact on your overall well-being. That's why we offer the Comprehensive Testosterone Test Panel, an advanced diagnostic tool designed to provide a complete understanding of your testosterone levels.

Our Bioavailable Testosterone Test Panel is a unique set of five crucial tests that provide a detailed analysis of different testosterone components. Suitable for both men and women, this panel is specifically designed to cater to the needs of those with high testosterone levels.

1. Testosterone, Total, LC/MS

• Ideal for: Men with high testosterone and women
• Method: Liquid Chromatography-Mass Spectrometry (LC/MS)
• Description: This test measures the total testosterone in your blood, without an upper or lower limit. The LC/MS method ensures the most accurate reading, essential for understanding the overall testosterone status.

2. Testosterone, Free

• Method: Calculated based on LC/MS/MS-derived total testosterone and equilibrium dialysis-derived percent free levels.
• Description: Free testosterone accounts for the unbound and bioactive portion of testosterone in your system. This measurement is vital for evaluating hormonal balance and potential deficiency or excess.

3. Testosterone, Bioavailable

• Method: Calculated using LC/MS/MS-derived total testosterone, equilibrium dialysis-derived percent free testosterone levels, albumin, and SHBG.
• Description: Bioavailable testosterone represents the portion of testosterone that is readily available to the body's tissues. This precise calculation offers insight into your hormonal state and how it may affect your health.

4. Sex Hormone Binding Globulin (SHBG)

• Description: SHBG is a protein that binds to sex hormones, including testosterone. By understanding the levels of SHBG, we can interpret how much testosterone is available for the body to utilize. It plays a vital role in determining the effectiveness of hormone replacement therapy or identifying hormonal imbalances.

5. Albumin

• Description: Albumin is a protein found in blood plasma that helps to transport hormones like testosterone. Measuring albumin levels is essential in calculating bioavailable testosterone and aids in the understanding of overall metabolic and liver health.

Why Choose Our Bioavailable Testosterone Test Panel?

This panel provides an in-depth understanding of your hormonal landscape, a crucial aspect of various health concerns such as fertility, muscle development, metabolism, and mood regulation. Our user-friendly online platform ensures quick scheduling, accurate testing, and prompt results at an affordable price.

Trust DiscountedLabs.com for a comprehensive insight into your hormonal health. Contact us today to schedule your Comprehensive Testosterone Test Panel or to learn more about our extensive range of lab tests designed to keep you in control of your well-being.

Note: The lab requisition form will list this test as 

Testosterone, Free, Bioavailable and Total, Males (Adult)

without including SHBG.  No worries!  The results will include SHBG since it is needed to calculate bioavailable testosterone.

IMPORTANT: Discounted Labs only serves these states: Find a Location 

FREE BONUS: EBook: Beyond Testosterone

Suggested Reading: Testosterone Replacement Blood Test Targets

How does DiscountedLabs.com work: Click here

This economical lab test panel includes:

• Testosterone, Total (Immunoassay- Upper Limit 1,500 ng/dL)

• Testosterone, Free (Calculated)

• Testosterone, Bioavailable (Calcuated)

• Sex Hormone Binding Globulin -SHBG

• Complete Blood Count CBC panel- Includes Hematocrit

• Albumin

• PSA

• Ultrasensitive Estradiol (LC/MS)

Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

IMPORTANT: Discounted Labs only serves these states: Find a Location 

HOW DOES DISCOUNTEDLABS.COM WORK?

1. Go to the "Find a Location" page to find the closest lab location. No need to make an appointment since walk-ins are welcomed. Once you have identified your closest location, go to step 2.

2. Go to "Choose a Test" and add your selection (s) in the shopping cart. If you prefer to save money on bundled tests, we have created "Lab Test Panels" that can help you decide what to order.

3. If you have a discount coupon code, add it to your cart.

4. A $8 lab processing fee will be added to your total.

5. Pay using a credit card.

6. You will receive an order confirmation and instructions email on how to download your lab request.

7. Print lab request form that you downloaded.

8. Take that form to the closest Quest Diagnostics location with a picture ID. Get your blood drawn.

9. You will receive an email when the results are ready for you to download.

   Note: You cannot place an order under someone else's profile. The profile person's name will appear on the lab order form.

   If you have questions, please review our FAQ Page.

   If you have further questions, please email [email protected].

Ordering these 5 hormone tests as a panel saves you $10 when comparing it to buying tests separately.

- Total and Free Testosterone ( LC/MS assay that can measure with no upper limit)

This test measures both total testosterone by the most liquid chromatography/ mass spectrometry with no upper limit (suitable even for TT levels above 1500 nd/dL). Free testosterone by Equilibrium Dialysis.

- TSH, free T4 and free T3

This panel includes comprehensive testing of the thyroid stimulating hormone (TSH) in addition to free thyroxine (T4) and free triiodothyronine (T3). When the thyroid gland does not produce enough hormone, the body uses energy at a slower pace than it should. This condition, underactive thyroid, is called hypothyroidism.  

- Ultra-Sensitive Estradiol (LC/MS)

Estradiol is produced by the body via the aromatization of testosterone in fat tissue, liver, and testicles. Estradiol is involved in bone health, cognitive function, sex drive, and body composition in both men and women. Depending on lifestyle factors, liver Issues, medications, body fat mass, and genetics, some people may have higher estradiol conversions from testosterone.

The commonly used estradiol test may overestimate estradiol. That test uses immunoassay technology that cannot differentiate C-Reactive Protein (involved in inflammation) from estradiol, so it reads the combination of the two as estradiol. This ultra-sensitive estradiol test is based on liquid chromatography/mass spectrometry (LC/MS), an assay technology that does not have that limitation.

NOTE: If you are taking biotin, please stop it 72 hours before the blood draw since it may interfere with hormone blood tests.

IMPORTANT: Discounted Labs only serves these states: Find a Location 

FREE BONUS: EBook: Beyond Testosterone

Suggested Reading: Testosterone Replacement Blood Test Targets

How does DiscountedLabs.com work: Click here

First time customer? Please read this before ordering: How Does Discounted Labs Work?

This is a very economical panel that includes:

1- Hematocrit: Portion of total blood volume made up of red blood cells. Testosterone replacement therapy can increase hematocrit. Hematocrit  over 52 may increase blood thickness and cardiovascular risks. 

2- Total Testosterone (LC/MS- No Upper Limit) and  Free Testosterone (Equilibrium Dialysis) 

 If you have any questions, please visit our FAQ page.

IMPORTANT: Discounted Labs only serves these states: Find a Location 

FREE BONUS: EBook: Beyond Testosterone

Suggested Reading: Testosterone Replacement Blood Test Targets

How does DiscountedLabs.com work: Click here

This panel includes total testosterone measured by the most accurate method (liquid chromatography/mass spectrometry LC/MS), free testosterone percent by equilibrium dialysis, and free testosterone calculated from percent free T. It is adequate for men who expect high T levels and women (LC/MS is accurate for high and low T levels also).