Thyroglobulin Antibody


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This test measures antithyroglobulin antibodies that are commonly present in patients with Hashimoto's thyroiditis. Antibodies against the protein thyroglobulin can result in the destruction of thyroid cells. This destruction can lead to hypothyroidism.

 Antithyroglobulin antibodies are present in patients with Hashimoto's thyroiditis. Antibodies against the protein thyroglobulin can result in the destruction of thyroid cells. This destruction can lead to hypothyroidism.

NOTE: If you are taking biotin, please stop it 72 hours before the blood draw since it may interfere with hormone blood tests.


Thyroglobulin Antibody – Everything You Need to Know

Before getting deeper into the subject, you may want to have some background information about thyroid, antibodies, hormones, and how all these affect you.

The thyroid can be defined as a small gland, often compared with a butterfly in terms of shape. It lays at the base of your throat and is responsible for producing hormones that serve several processes in our bodies.

It is involved in the process of regulating your weight, controls body temperature and mood, and plays a role as well in muscle strength.

The thyroid uses thyroglobulin in its releasing hormones process to do these functions. If you have an autoimmune disorder, thyroglobulin production may be disrupted.

We know that our immune system is something that we should nurture and care for most as it helps us stay healthy and happy. What you may don't know is that the immune system makes some proteins called antibodies. Antibodies have the role of fighting bacteria or viruses.

The overall role of the antibodies is to protect our organism. However, there are cases when they also attack good cells produced by your body, organs, and tissues. This event is called an autoimmune response.

TPO antibodies are created when the immune system of a person targets by pure error elements of the thyroid gland or protein, leading to chronic thyroid inflammation, tissue damage, and damage to the thyroid function. Leaving this untreated may cause severe health issues.

Thyroid antibodies are different in terms of their manner of action. While some may lead to thyroid tissue destruction, others influence an increase of a specific thyroid hormone. The most common types of antibodies tested are TPO, TG, and TSH.

This article will have as a debated subject the thyroglobulin antibody. You will learn what this is, how it works, and what diseases are associated with it.

What is the Purpose of a Thyroglobulin Antibody Test?

As the same for any test, before ordering you, you should listen to your symptoms and even more to your healthcare provider. It is also important to inform your doctor if anyone from your family suffers from an autoimmune disease.

General symptoms you may encounter which are associated with thyroglobulin antibodies are:

  • An increase in your weight that cannot be explained
  • Skin and hair dryness
  • Weakness
  • Goiter development
  • Regular constipation

The test is usually performed to:

  • Detect Hashimoto's or Graves` disorders and identify what thyroid function is damaged
  • Monitor progress in treatments for the issues found
  • Monitor patients with hypothyroidism and predict its course
  • Evaluate and supervise a pregnancy in case the mother suffers from any thyroid affection (during the pregnancy, these disorders may worsen)
  • Follow-up for persons diagnosed and treated in the past for thyroid cancer
  • Verify suspicion of autoimmune thyroiditis with negative thyroid-specific anti Peroxidase

In the United States, the most common thyroid disorder is Hashimoto's thyroiditis, affecting over 14 million citizens.

Moreover, Graves and Hashimoto disorders are known to influence other issues such as hypothyroidism or hyperthyroidism. This happens because of the interference of the immune system with the thyroid gland, affecting its course.

What Should You Know Before Doing the Thyroglobulin Antibody Test?

The most important aspect would be for you to discuss with your healthcare provider about the medication and supplements you take.

Some of them may interfere with the components of certain medications and lead to inconclusive results. One example is the Biotin supplement; you may need to stop administration before the test.

Regarding the test in itself, it can be done in any lab. Some of them offer packages in which this test is included alongside other hormone tests usually required for a more specific diagnosis.

What do the Results May Indicate?

For this test, the best outcome is to have a negative result which means there were no antithyroglobulin antibodies detected in your blood.

In case the result of the test turned positive, with small amounts of antibodies found, then one of the following disorders may be the cause:

  • Biermer anemia (due to a deficit of vitamin B12) is also known as pernicious anemia or Addison-Biermer anemia
  • Type 1 Diabetes
  • Rheumatoid arthritis or scleroderma
  • A type of thyroid cancer

In case the result of the test turned positive, with high amounts of antibodies found, then one of the following disorders may be the cause:

  • Graves disease
  • Hashimoto thyroiditis

Symptoms and Particularities of Hashimoto's Thyroiditis

Hashimoto thyroiditis is an autoimmune disease affecting thyroid function, which may create many imbalances in our body.

What causes it is not particularly known, but factors like family history associated with autoimmune disorders, gender, age, or being diagnosed already with another autoimmune disease may increase the risk of developing it.

Even though Hashimoto thyroiditis does not have particular symptoms that differentiate it from other diseases, there may be cases when persons develop goiter. Usually, goiter is not painful at the touch but may cause discomfort when swallowing.

Other symptoms of Hashimoto's Disease that you may encounter:

  • Regular constipation
  • Dry skin and hair
  • Elevated cholesterol
  • Depression or fatigue
  • Muscle weakness, especially in the lower members
  • Feeling dull
  • Cold sensitivity

Symptoms and Particularities of Graves' Disease

Known as the most known and diagnosed form of hyperthyroidism, Graves disease is an autoimmune disease provoked by an excess of thyroid hormone produced by the thyroid gland.

As a response to Graves disease, the immune system produces antibodies that link to a healthy thyroid cell and provoke the thyroid to produce the excess thyroid hormone.

This disease usually develops in people under 40, women being more prone to develop it. Family history, age, stress, or even other autoimmune diseases you may have, such as Crohn's, RA, or type 1 diabetes, may increase the risk for Graves disease.

If it is not treated, this disease can damage your heart and bones and have pregnancy problems. This is why it is highly recommended to seek treatment as soon as possible.

The most common symptoms of Graves' disease are:

  • Tachycardia
  • Hard to tolerate heat
  • Goiter
  • Irritability
  • Sleeping issue
  • Prone to fertility
  • Abnormal periods (heavy, irregular)
  • Dermopathy
  • Ophthalmopathy


Order Your Test Now

If you experience several symptoms associated with thyroglobulin antibody disorders or if you know someone from your family with such medical history, contact your healthcare provider and ask for a check-up. As soon as you get treatment for any condition, the sooner you will feel better again. For more hormone-related information and tests, go to and order your test through an easy process close to your home.







  1. Go to the "Find a Location" page to find the closest lab location. No need to make an appointment since walk-ins are welcomed. Once you have identified your closest location, go to step 2.

  2. Go to "Choose a Test" and add your selection (s) in the shopping cart. If you prefer to save money on bundled tests, we have created "Lab Test Panels" that can help you decide what to order.

  3. If you have a discount coupon code, add it to your cart.

  4. A $8 lab processing fee will be added to your total.

  5. Pay using a credit card.

  6. You will receive an order confirmation and instructions email on how to download your lab request.

  7. Print lab request form that you downloaded.

  8. Take that form to the closest location. Get your blood drawn.

  9. You will receive an email when the results are ready for you to download.

    Note: You cannot place an order under someone else's profile. The profile person's name will appear on the lab order form.


    If you have further questions, please email [email protected].

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