Estrone (E1) is one of the three estrogens, which also includes estriol and estradiol. Estrone is the least abundant of the three and is relevant to health and disease because it is considered the stronger acting estrogen.
What is Estrone?
There are three major estrogens that are produced in women, which are estrone (E1), estradiol (E2), and estriol (E3). For women who are in their reproductive years, estradiol is the most active type of estrogen and has the highest levels. The predominant hormones change during pregnancy when estriol levels are higher and during menopause when estrone is the only estrogen that continues to be produced.
Estrone is found in increased amounts in postmenopausal women. Because of that and its connection to an increased risk of cancer it is not included as part of estrogen replacement therapy. Taking estradiol orally can lead to increased levels of estrone as it is metabolized by the liver. Increased levels of estrone in the body are avoided by the use of non-oral methods of estradiol delivery like creams and gels.
Estrone, as well as the other estrogens, are synthesized from cholesterol and secreted mainly from the ovaries, though it can also be formed from adrenal androgens in adipose tissue. Relative to estradiol, both estrone and estriol have far weaker activity as estrogens.
Estrone, a synthetically prepared or naturally occurring steroidal estrogen obtained from pregnant equine urine, is the primary circulating estrogen after menopause. Estrone is naturally derived from the peripheral conversion of androstenedione by an aromatase enzyme found in adipose tissues and is converted to estradiol in peripheral tissues. The estrogenic potency of estrone is one third that of estradiol. Estropipate is piperazine-stabilized estrone sulfate. Estrone, and estropipate are used to treat abnormalities related to gonadotropin hormone dysfunction, vasomotor symptoms, atrophic vaginitis, and vulvar atrophy associated with menopause, and for the prevention of osteoporosis due to estrogen deficiency.
If you are taking estrogen replacement therapy, it is important to follow the balance of the three main estrogens in your body. Imbalances in the relationship between estrone and the other two major estrogens are thought to increase the risk for many age-related diseases.
NOTE: If you are taking biotin, please stop it 72 hours before the blood draw since it may interfere with hormone blood tests.
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