Page 3 - Men's Health Lab Tests

Many people ask themselves: What are the top health tests that doctors use to diagnose the most common ailments that most of us have as we age? We will explore comprehensive blood tests such as Complete Blood Count (CBC), Comprehensive Metabolic Panel (CMP), and Blood Glucose Test to provide a solid foundation of knowledge on these essential examinations. Additionally, we'll discuss the importance of evaluating lipid profiles and thyroid function as we age and want to remain healthy and thriving. In addition, you'll be educated on assessing liver and kidney health through specific tests as well as the utilization of urinalysis for diagnosis. We'll also cover deficiency detection with Vitamin D and B12 testing, A1C testing for diabetes management and diagnosis, the C-reactive Protein (CRP) test as a cardiovascular risk indicator, and crucial cancer screening tests tailored to the needs of older adults. This comprehensive guide on top health tests aims to empower you with valuable information that can contribute positively to your overall well-being or that of your loved ones. Table of Contents: Comprehensive Blood Tests for Older Adults Complete Blood Count (CBC) Basic Metabolic Panel (BMP) Blood Glucose Test Evaluating Lipid Profile and Thyroid Function Lipid Profile Test Thyroid Function Tests Assessing Liver and Kidney Health Liver Function Tests Kidney Function Tests Urinalysis as a Diagnostic Tool The Importance of Urinalysis for Older Adults Tips for Accurate Urine Sample Collection Deficiencies Detection: The Importance of Vitamin D and B12 Testing Vitamin D Test Vitamin B12 Test A1C Testing For Diabetes Management And Diagnosis The Importance of Hemoglobin A1C Test Frequency of Hemoglobin A1C Testing Managing Diabetes Through Lifestyle Changes C-Reactive Protein (CRP) as a Cardiovascular Risk Indicator Why CRP Testing Matters for Older Adults Factors Affecting C-Reactive Protein Levels Additional Tests to Assess Cardiovascular Risk in Older Patients Cancer Screening Tests for Older Adults Prostate-Specific Antigen (PSA) Test Mammogram Fecal Occult Blood Test Conclusion Comprehensive Blood Tests for Older Adults As we age, it becomes increasingly important to monitor our health and detect potential issues early on. Monitoring health and detecting potential issues early on can be done effectively through comprehensive blood tests that provide valuable insights into an individual's overall well-being. In this section, we will discuss three key lab tests often utilized by physicians when evaluating older patients: Complete Blood Count (CBC), Comprehensive Metabolic Panel (CMP), and Blood Glucose Test. Complete Blood Count (CBC) The Complete Blood Count, or CBC, is a common test that measures various components in the blood such as white blood cells, red blood cells, hemoglobin levels, hematocrit values and platelet count. These measurements can help doctors identify conditions like anemia or infections which may require further investigation or treatment. White blood cells: High levels may indicate infection or inflammation; low levels could suggest immune system problems. Red blood cells: Low counts might be due to anemia while high counts could point towards dehydration or other underlying issues. Hemoglobin & Hematocrit: Abnormal results can also signal anemia or other disorders affecting red blood cell production. Platelets:Adequate platelet numbers are essential for proper clotting; abnormal values may warrant further evaluation for bleeding disorders. Comprehensive Metabolic Panel (CMP) The Comprehensive Metabolic Panel (CMP) is another important blood test that evaluates the levels of electrolytes, kidney function markers, and blood glucose. This panel provides insights into how well an individual's body is maintaining its fluid balance, filtering waste products from the bloodstream, and regulating blood sugar levels. Electrolytes: Imbalances in sodium, potassium or calcium can affect muscle function and nerve signaling; abnormal values may indicate dehydration or other health issues. Kidney Function Markers: Elevated creatinine or BUN (blood urea nitrogen) levels could suggest impaired kidney function requiring further assessment. Blood Glucose: High fasting glucose readings might be a sign of diabetes while low values could point towards hypoglycemia. Blood Glucose Test A standalone Blood Glucose Test , often performed as part of routine checkups for older adults, measures the amount of sugar present in your bloodstream at any given time. As mentioned earlier within BMP context this test helps physicians identify potential cases of diabetes prediabetes or hypoglycemia all conditions which require close monitoring management especially among aging population where risks complications are higher Maintaining healthy range essential preventing long-term damage nerves vessels organs associated with uncontrolled high sugars ensuring optimal quality life longevity Comprehensive blood tests for older adults are essential in assessing the overall health of seniors. Evaluating lipid profile and thyroid function can provide further insight into an individual's health status.   Key Takeaway:  Discounted Labs provides lab tests at affordable prices in various U.S. cities without the need for a doctor's appointment, and their focus is on health tests for elderly individuals. They offer convenient and accessible services that allow seniors to monitor their health regularly without breaking the bank or leaving home. Evaluating Lipid Profile and Thyroid Function Monitoring lipid levels is crucial for assessing cardiovascular risk factors in older patients, while thyroid function tests help identify hormonal imbalances that may affect metabolism, energy levels, or mood. In this section, we will discuss the importance of Lipid Profile Test and Thyroid Function Tests as essential health assessments for elderly individuals. Lipid Profile Test A Lipid Profile Test, commonly known as a cholesterol test or lipoprotein panel, assesses the amount of various fats present in one's blood. These include: Total Cholesterol (TC) HDL-C, also known as the "good" cholesterol, can help to rid your arteries of surplus cholesterol. Low-Density Lipoprotein Cholesterol (LDL-C) - commonly called "bad" cholesterol since high levels can lead to plaque buildup in your arteries and increase the risk of heart disease. Triglycerides - another type of fat found in the blood which can contribute to hardening or narrowing arterial walls if elevated. Routine lipid profile testing enables physicians to evaluate an individual's overall cardiovascular health status by identifying any potential risks associated with abnormal lipid concentrations. Early detection allows for timely intervention through lifestyle modifications such as diet changes or medication adjustments aimed at maintaining optimal heart health during aging years. Thyroid Function Tests Thyroid Function Tests are essential in assessing the health of your thyroid gland, which is responsible for producing hormones that regulate various bodily functions such as metabolism, body temperature, and heart rate. These tests typically measure levels of: Thyroid-Stimulating Hormone (TSH) - a hormone produced by the pituitary gland to stimulate thyroid hormone production. Free Thyroxine (FT4) - an active form of thyroxine, one of the primary thyroid hormones. Free Triiodothyronine (FT3) - another active thyroid hormone that helps regulate metabolic processes within cells. Imbalances in FT4 and FT3 levels can cause hypothyroidism or hyperthyroidism, which can manifest as fatigue, weight changes, and mood disturbances. Regular testing allows physicians to monitor patients' hormonal balance and adjust treatment plans accordingly for optimal well-being throughout their golden years. It is critical to comprehend the significance of assessing lipid levels and thyroid activity in order to preserve optimal health. Assessing liver and kidney health can help identify any potential issues that may be causing problems for elderly individuals.   Key Takeaway:  Discounted Labs offers affordable lab tests in most U.S. cities without requiring a doctor's visit, making it easy for elderly individuals to monitor their health. With Discounted Labs, seniors can keep tabs on their well-being and catch any potential issues early on before they become more serious. Assessing Liver and Kidney Health To ensure their proper functioning, regular assessment of liver and kidney health is paramount for older adults. Regularly monitoring their performance through lab tests can help detect any potential issues early on, allowing for timely intervention and treatment. In this section, we will discuss two essential tests: Liver Function Tests (LFTs) and Kidney Function Tests (KFTs). Liver Function Tests Liver function tests are a group of blood tests that measure various enzymes, proteins, and other substances produced by the liver to assess its health. These include: Alanine Aminotransferase (ALT) Aspartate Aminotransferase (AST) Alkaline Phosphatase (ALP) Bilirubin Globulin levels Total Protein levels. Elevated levels of these markers may indicate liver damage or disease such as hepatitis, cirrhosis or fatty liver disease. It is important to monitor these values regularly since many liver conditions do not exhibit symptoms until they have progressed significantly. For more information about LFTs and how they can help maintain your liver health, visit the Mayo Clinic's guide on Liver Function Tests. Kidney Function Tests Kidney function tests,, also known as renal function panels evaluate how effectively kidneys filter waste products from the bloodstream - an essential component of maintaining optimal health in aging individuals. Common tests include: Blood Urea Nitrogen (BUN) Creatinine Estimated Glomerular Filtration Rate (eGFR). Abnormal amounts of these indicators may point to kidney damage or illnesses, such as chronic renal disorder, acute renal failure, or urinary tract infections. Early detection and management of kidney issues are crucial for preventing further complications like end-stage renal disease requiring dialysis or transplantation. To learn more about KFTs and their importance in older adults' health, check out the National Kidney Foundation's overview on Kidney Function Tests. Incorporating liver and kidney function tests into your regular healthcare routine is an essential step towards ensuring a healthy life as you age. By keeping track of these vital organ functions through lab testing offered by DiscountedLabs.com, you can take control over your well-being and address any potential concerns before they become severe problems. To ensure good health, it is important to understand the various tests available for assessing liver and kidney function. Examining urine can give an abundance of insight into someone's physical state and should be taken into account when assessing overall health.   Key Takeaway:  Discounted Labs offers affordable lab tests in most U.S. cities without requiring a doctor's visit, making it easier for elderly individuals to monitor their health. With Discounted Labs, seniors can stay on top of their well-being without breaking the bank or leaving home. Urinalysis as a Diagnostic Tool Urinalysis, a non-invasive screening method, is used to assess the health of the urinary tract and detect potential problems related to glucose levels or infection. It can also help monitor chronic diseases such as diabetes by detecting abnormal glucose levels or signs of infection in urine samples. In older adults, urinalysis plays an essential role in identifying and managing potential health issues related to the kidneys and bladder. The Importance of Urinalysis for Older Adults As people age, their risk for developing kidney-related problems increases due to factors like reduced kidney function, medications that affect renal function, and other age-related changes. Studies have shown that early detection of these issues through regular urinalysis can significantly improve patient outcomes and prevent further complications. Detecting Kidney Disease: By measuring components such as protein, red and white blood cells, creatinine levels, and specific gravity in urine samples; urinalysis helps identify early signs of kidney disease or damage before it progresses into more severe stages. Evaluating Bladder Health: Urinary tract infections (UTIs) are common among older adults due to weakened immune systems or incomplete bladder emptying caused by prostate enlargement in men or pelvic organ prolapse in women. A simple urinalysis can detect bacteria presence indicating UTI requiring prompt treatment with antibiotics. Maintaining Diabetes Management:For diabetic patients who require close monitoring of their blood sugar levels; abnormalities detected during routine urinalsyses may indicate poor glycemic control which warrants adjustments medication regimen lifestyle modifications li > Tips for Accurate Urine Sample Collection For optimal results, it's crucial to collect a clean and uncontaminated urine sample. Here are some tips for ensuring accurate urinalysis: Use a Clean Container: Obtain a sterile container from your healthcare provider or pharmacy to prevent contamination of the sample. Clean Catch Midstream Technique:This method involves starting the flow of urine before collecting the midstream portion in the container, which helps minimize bacterial contamination from external genitalia. Incorporating regular urinalysis into an older adult's health care routine is essential for maintaining optimal kidney and bladder function while also monitoring chronic conditions like diabetes. By detecting issues early through comprehensive lab tests such as urinalysis; physicians can implement timely interventions improving overall well-being longevity aging individuals . Urinalysis can be a useful diagnostic and monitoring technique when it comes to evaluating the health of elderly individuals. Deficiencies detection provides another layer of insight into potential underlying issues, such as Vitamin D or B12 deficiencies, which can be identified through simple tests.   Key Takeaway:  Discounted Labs offers lab tests at an affordable price without requiring a doctor's visit in many cities across the United States. The company provides health tests for elderly individuals to help them monitor their overall well-being and detect any potential health issues early on, allowing for timely treatment and prevention of further complications. Deficiencies Detection: The Importance of Vitamin D and B12 Testing As we age, our bodies may not be able to absorb essential nutrients as efficiently, leading to potential deficiencies that can negatively affect overall health. Two key vitamins that can help to ensure optimal health, particularly for the aging population, are vitamin D and B12. By testing levels of these vitamins, physicians can determine if their patients have any deficiencies which could lead to bone weakness, fatigue, cognitive decline, and other symptoms commonly associated with the aging population. Vitamin D Test Vitamin D is required to keep bones healthy, aiding the body in taking up calcium from food sources. A deficiency in this vital nutrient can result in osteoporosis, a condition characterized by weak and brittle bones prone to fractures. Older individuals are more likely to experience a lack of vitamin D due to reduced sun exposure or impaired ability for the skin to make it effectively. Sources: Fatty fish like salmon or mackerel; fortified dairy products; sunlight exposure Risks: Bone loss; muscle weakness; mood changes Treatment: Supplements prescribed by a healthcare professional based on individual needs; Vitamin B12 Test Vital for nerve function and red blood cell production, vitamin B12 plays an important role in energy metabolism and brain health. Deficiency symptoms include fatigue, memory problems, cognitive decline, and even anemia. As we age, our bodies may struggle to absorb vitamin B12 from food sources due to a decrease in stomach acid production or other gastrointestinal issues. Sources: Animal products such as meat, poultry, fish, eggs; fortified cereals for vegetarians/vegans; Risks: Anemia; neurological problems; fatigue; Treatment: Supplements prescribed by a healthcare professional based on individual needs; Incorporating these essential tests into routine health evaluations can help older adults maintain optimal well-being and address any deficiencies before they lead to more severe complications. By staying proactive about their nutrient levels through regular testing at facilities like DiscountedLabs.com, individuals can take control of their health and ensure they are receiving the necessary support for overall vitality. Testing for any shortcomings can assist in monitoring your physical and mental health. A1C testing is a great way to manage diabetes and diagnose any potential issues that may arise.   Key Takeaway:  Discounted Labs offers lab tests at a lower price without requiring a doctor's visit in most U.S. cities, with a focus on elderly health tests. This service provides an affordable and convenient option for seniors to monitor their health and detect potential issues early on. A1C Testing For Diabetes Management And Diagnosis As the years pass, the possibility of having diabetes rises. The Hemoglobin A1C test is a critical tool for diagnosing and managing diabetes in older adults. This blood test measures average blood sugar levels over the past 2-3 months, providing insight into long-term glycemic control. The Importance of Hemoglobin A1C Test Early detection: Regular A1C testing can help identify prediabetes or undiagnosed diabetes at an early stage, allowing for timely intervention and lifestyle changes to prevent complications. Glycemic control monitoring: For those already diagnosed with diabetes, regular A1C tests are essential in evaluating how well their treatment plan is working and making necessary adjustments to medications or lifestyle habits. Risk assessment: High A1C levels are associated with an increased risk of cardiovascular disease and other health issues. By keeping track of these levels, physicians can better assess potential risks and recommend appropriate preventive measures. Frequency of Hemoglobin A1C Testing The frequency at which older adults should undergo Hemoglobin A1C testing depends on their current health status and individual needs. Generally speaking: If you have not been diagnosed with diabetes but have certain risk factors (such as obesity or family history), it's recommended that you get tested every three years starting at age 45. For those with a high risk of developing diabetes, annual testing is recommended. For those already diagnosed with diabetes, A1C tests are typically performed every 3-6 months to monitor glycemic control and adjust treatment plans as needed. In addition to the Hemoglobin A1C test, older adults should also undergo regular blood glucose testing. This can help detect sudden spikes or drops in blood sugar levels that may require immediate attention. Consult your healthcare provider for personalized recommendations on how often you should get tested based on your specific needs and health history. Managing Diabetes Through Lifestyle Changes Apart from medications prescribed by a doctor, there are several lifestyle changes that can significantly improve blood sugar control in older adults: Dietary modifications: Adopting a balanced diet rich in whole grains, lean proteins, healthy fats, fruits and vegetables is essential for managing diabetes. Limiting processed foods and added sugars can also help maintain stable blood sugar levels throughout the day. Consider consulting a registered dietitian for personalized dietary advice tailored to your needs. Physical activity: Regular exercise plays an important role in maintaining good glycemic control. Aim for at least 150 minutes of moderate-intensity aerobic activity per week (such as brisk walking) along with muscle-strengthening activities twice weekly (CDC guidelines). Always consult your healthcare provider before starting any new exercise program. Blood glucose monitoring: Self-monitoring of blood glucose levels using a glucometer helps identify patterns or trends that may indicate the need for adjustments in medication dosages or meal planning strategies. By remaining proactive in managing diabetes through regular A1C testing and adopting healthy lifestyle habits, older adults can significantly reduce their risk of complications and enjoy a better quality of life. A1C testing is a significant way to track and regulate diabetes, as it gives an idea of someone's typical blood sugar levels in the last couple of months. C-reactive protein (CRP) tests can provide additional information on cardiovascular health risk by measuring inflammation in the body.   Key Takeaway:  Discounted Labs provides affordable lab tests in various cities across the United States, allowing customers to access health tests without visiting a doctor. The company's services are particularly beneficial for elderly individuals who may require frequent testing but have limited mobility or financial resources. C-Reactive Protein (CRP) as a Cardiovascular Risk Indicator The C-reactive protein (CRP) test is an essential blood test that measures inflammation levels in the body. CRP testing can be used to identify early signs of cardiovascular disease, enabling physicians to provide timely intervention and treatment that may improve health outcomes. By identifying potential risks at an early stage, physicians can initiate timely intervention and treatment to improve overall health outcomes. Why CRP Testing Matters for Older Adults Detecting hidden inflammation: CRP testing helps identify low-grade chronic inflammation that may not cause noticeable symptoms but could still contribute to the development of heart disease over time. Risk stratification: High levels of CRP are associated with a higher risk of cardiovascular events such as heart attacks and strokes. Knowing a patient's CRP level allows physicians to tailor prevention strategies accordingly. Monitoring response to treatment: Changes in CRP levels can help gauge the effectiveness of lifestyle modifications or medications aimed at reducing cardiovascular risk factors like high cholesterol or hypertension. Factors Affecting C-Reactive Protein Levels Age, sex, genetics, obesity, smoking status and other medical conditions such as diabetes or rheumatoid arthritis can all affect CRP levels in older adults. It is important for clinicians to consider these factors when interpreting results from a CRP test and determining the best course of action for their patients. Additional Tests to Assess Cardiovascular Risk in Older Patients In addition to CRP testing, physicians may recommend other tests to further evaluate cardiovascular risk in older adults. These can include: Lipid profile: A comprehensive assessment of cholesterol levels, including total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides. Blood pressure measurement: Regular monitoring of blood pressure is crucial for detecting hypertension - a major risk factor for heart disease and stroke. Glycated hemoglobin (A1C) test: This test measures long-term blood sugar control, providing insight into diabetes management - another key contributor to cardiovascular disease risk. Maintaining good health as we age involves regular medical check-ups and appropriate screening tests like the C-reactive protein test. By staying proactive about our health care needs, we can better manage potential risks and enjoy a higher quality of life well into our golden years. The CRP exam can be a useful gauge of cardiovascular hazard in the elderly, and should thus be taken into account when assessing overall well-being. Cancer screening tests are also critical for older adults, so it's essential to understand which ones may be necessary.   Key Takeaway:  Discounted Labs offers low-cost lab tests in various cities across the United States without requiring a doctor's appointment. The focus of this project is to explore health tests for elderly individuals, ensuring that they receive proper care and attention as they age gracefully. Cancer Screening Tests for Older Adults Regular cancer screenings are essential for early detection and timely treatment. Prostate-specific antigen tests, mammograms, and fecal occult blood tests are commonly used to screen for prostate, breast, and colorectal cancers respectively. In this section, we will discuss the importance of these screening tests in maintaining the health of older adults. Prostate-Specific Antigen (PSA) Test The Prostate-Specific Antigen (PSA) test is a blood test that measures the level of PSA in men's blood. High PSA levels may be indicative of prostate cancer or other non-cancerous conditions such as prostatitis and an enlarged prostate. The American Cancer Society recommends discussing with your doctor about whether to have a PSA test starting at age 50 for men at average risk; however, those with higher risk factors should consider testing earlier. Mammogram A mammogram is an X-ray image of the breast that helps detect breast cancer early when it's most treatable. Women aged 50-74 years should have a mammogram every two years according to the U.S Preventive Services Task Force guidelines; however, women aged 40-49 years should talk to their healthcare provider about when they should start getting screened based on individual risks and preferences. Breast Self-Awareness: It's important for women to be familiar with the normal look and feel of their breasts, as changes can be an early sign of breast cancer. Report any unusual changes to your healthcare provider promptly. Fecal Occult Blood Test The Fecal Occult Blood Test (FOBT) is a non-invasive test that checks for hidden blood in the stool, which may be an early sign of colorectal cancer or other digestive issues. For those at higher risk, the American Cancer Society recommends discussing earlier colorectal cancer screening options with their healthcare provider starting from age 45. By undergoing these essential cancer screenings regularly, older adults can increase their chances of detecting potential health issues at an early stage and receiving timely intervention and treatment. Remember to consult your physician about the appropriate tests based on your medical history, risk factors, and specific needs.   Key Takeaway:  Discounted Labs offers low-cost lab tests in many U.S. cities without requiring a doctor's appointment, making it easier for people to monitor their health. The company specializes in providing affordable testing options for seniors, who may need more frequent check-ups as they age. Conclusion As we  age, it is important to be aware of the different health tests that are available and beneficial. Regular testing can help detect potential issues before they become more serious. Health tests such as comprehensive blood work, lipid profiles, thyroid function evaluations, liver and kidney assessments, urinalysis for deficiencies detection and A1C testing for diabetes management should all be considered when evaluating an individual's overall wellbeing. Additionally C-Reactive Protein (CRP) may indicate cardiovascular risk while cancer screening tests can provide valuable insight into a person’s current state of health. Knowing which elderly health tests to have done on a regular basis is key in helping to maintain good physical condition over time. Take control of your health and save money by ordering affordable lab tests through DiscountedLabs.com, without the need for a doctor's visit! Get access to elthe top health tests quickly and easily today.    

Accurate estradiol testing is of great importance for both genders in order to preserve optimal health, well-being, and physical condition. Estradiol, a type of estrogen hormone essential for reproductive health and various physiological processes, must be accurately measured to ensure optimal health. Measuring estradiol levels with precision can help identify low or high levels that may be associated with various medical conditions. In this blog post, we will delve into the importance of accurate estradiol testing in males and discuss the limitations of immunoassay-based tests - including their inaccuracy at lower concentration ranges and potential interference from C-reactive protein (CRP). We will then explore the advantages of sensitive LC/MS estradiol tests for males, such as improved sensitivity and specificity along with reduced influence from CRP or associated factors. Furthermore, we'll examine a study comparing immunoassay and mass spectrometry measurements while highlighting its implications on inflammation-related outcomes. Finally, we'll touch upon how accurate estradiol testing impacts hormone management strategies and testosterone replacement therapy monitoring. Table of Contents: Importance of Accurate Estradiol Testing in Males The Role of Estradiol in Men's Health Why Traditional Estradiol Tests May Not Be Sufficient for Men Limitations of Immunoassay-Based Estradiol Tests Inaccuracy at Lower Concentration Ranges Potential Interference from C-Reactive Protein (CRP) Advantages of Sensitive LC/MS Estradiol Test for Males Improved Sensitivity and Specificity Reduced Influence from CRP or Associated Factors Study Comparing Immunoassay and Mass Spectrometry Measurements Moderate Correlation Between Testing Methods Influence on Inflammation-Related Outcomes Implications for Hormone Management and Testosterone Replacement Therapy Monitoring Frequently Asked Questions Accurate Estradiol Testing What is the most accurate way to test estrogen levels? Are estrogen tests accurate? Can estradiol test wrong? What is the best estradiol test? What day is best to test estradiol? Conclusion Importance of Accurate Estradiol Testing in Males Measuring estradiol levels accurately is crucial for men's health, as low estradiol can negatively impact bone health, sex drive, and may lead to fat gain. It is essential for physicians not to overdiagnose high estradiol due to using an inaccurate test. In recent years, the importance of accurate estradiol testing has become more apparent with increasing awareness about its role in various aspects of male reproductive health. The Role of Estradiol in Men's Health Bone Health: Low estradiol levels have been linked to a higher risk of osteoporosis and fractures in men. Maintaining optimal serum estradiol levels helps preserve bone mineral density and prevent age-related bone loss. Sex Drive: Although testosterone plays a significant role in regulating libido, adequate estradiol concentrations are also necessary for maintaining healthy sexual function. Fat Gain: Studies have shown that low estrogen levels can contribute to increased abdominal fat accumulation and reduced insulin sensitivity in males. To ensure proper diagnosis and treatment strategies for patients experiencing symptoms related to imbalanced hormones like estrogen (estradiol), healthcare professionals must use the most accurate methods available when measuring these critical biomarkers. One such method gaining popularity among practitioners is the sensitive liquid chromatography-tandem mass spectrometry (LC/MS) assay - a highly precise technique capable of detecting even minute amounts present within blood samples taken from individuals being assessed during routine checkups or follow-up visits following initiation onto hormone replacement therapy regimens (source). Why Traditional Estradiol Tests May Not Be Sufficient for Men Immunoassays like ECLIA (Electrochemiluminescence Immunoassay) are frequently used to measure female estradiol levels. However, these tests may not be suitable for accurately determining low estradiol levels typically found in men due to their limited sensitivity and specificity at lower concentration ranges. Inaccurate test results can lead physicians to misdiagnose patients with high or low estradiol concentrations, potentially resulting in unnecessary treatments or interventions that could further exacerbate existing health issues rather than alleviate them. As a result, it becomes increasingly important for healthcare providers working within this field - particularly those specializing specifically within male reproductive medicine - adopt more advanced testing methodologies capable of providing accurate assessments regardless of whether someone has too much/too little circulating throughout their system (source). Immunoassay-based estradiol tests should be employed with caution, as their accuracy can be compromised by various factors. Understanding these limitations is critical for ensuring reliable results in male health monitoring. By better understanding potential interference from C-reactive protein (CRP) as well as the inaccuracy at lower concentration ranges, we can better assess our risk factors and make informed decisions about our health.   Key Takeaway:  Discounted Labs offers low-cost lab tests without a doctor's visit in many U.S. cities, and the topic of accurate estradiol testing is being discussed. Limitations of Immunoassay-Based Estradiol Tests Traditional immunoassay-based techniques, such as ECLIA (Electrochemiluminescence Immunoassay), have been widely used for measuring estradiol levels in the past. Immunoassay-based techniques, like ECLIA, are not as precise when detecting estradiol levels at lower concentrations that are more common in men. This can lead to misleading results and incorrect diagnoses or treatment plans. Inaccuracy at Lower Concentration Ranges Immunoassays perform best at higher concentrations suitable for adult females but struggle with precision and accuracy at the lower ranges commonly seen in males. As a result, they may overestimate or underestimate estradiol levels in men due to their limited sensitivity within this range (source). Consequently, healthcare professionals relying on these tests might not be able to make informed decisions about hormone management or monitoring testosterone replacement therapy. Potential Interference from C-Reactive Protein (CRP) Besides being inaccurate at lower concentration ranges, immunoassays can also be influenced by other factors present in blood samples that could interfere with test results. One such factor is C-reactive protein (CRP), an inflammation marker associated with various health conditions like obesity and cardiovascular disease. Interference: CRP has been shown to bind non-specifically with antibodies used in some immunoassays, leading to falsely elevated estradiol levels in men (source). Inflammation-related outcomes: Previous association studies between immunoassay E2 levels and inflammation-related outcomes might need reevaluation due to this potential interference. In light of these limitations, it becomes essential for healthcare professionals conducting hormone assessments on their patients' behalf - especially if they're trying accurately determine whether someone has too much or too little circulating throughout their system - opt instead for highly precise LC/MS technology rather than relying solely upon outdated methods employed previously via standard assays alone so as to ensure optimal results every time without fail. C-reactive protein (CRP) may have an impact on immunoassay-based estradiol tests, which can be inaccurate at lower concentration ranges. However, a more sensitive LC/MS test offers improved accuracy with reduced interference from CRP or associated factors.   Key Takeaway:  Discounted Labs offers lab tests without a doctor's visit in most U.S. cities, and the topic of accurate estradiol testing is being discussed. Advantages of Sensitive LC/MS Estradiol Test for Males The LC/MS assay offers greater sensitivity and specificity than traditional immunoassay-based techniques, such as ECLIA, for measuring estradiol levels in men at the lower concentrations typically found. These benefits include better sensitivity and accuracy at the lower concentrations of estradiol typically found in males, ensuring precise measurements without potential interference from other factors. Improved Sensitivity and Specificity One significant advantage of using the sensitive LC/MS estradiol test is its ability to accurately measure lower concentrations of this hormone. This is particularly important for men since their normal range falls within these low concentration levels. Healthcare professionals are better equipped to make decisions about potential treatments or lifestyle adjustments when they have access to more precise measurements. Reduced Influence from CRP or Associated Factors A study published in The Journal of Clinical Endocrinology & Metabolism revealed that immunoassay-based tests could be influenced by C-reactive protein (CRP) or associated factors, which might cause interference during analysis. The sensitive LC/MS assay significantly lessens this influence, allowing for more accurate results that are independent of outside factors. In addition to these advantages, the use of sensitive LC/MS technology ensures consistent results across different laboratories and testing facilities due to its standardized methodology. As a result, patients and healthcare providers can trust the accuracy and reliability provided by this advanced method of estradiol testing. The advantages of the sensitive LC/MS estradiol test for males are clear: improved sensitivity and specificity, as well as reduced influence from CRP or associated factors. It is critical to assess how these tests stack up when measuring inflammation-related results by looking into a comparison between immunoassay and mass spectrometry evaluations. "Get accurate and reliable estradiol testing with the sensitive LC/MS assay. Say goodbye to potential interference from external factors. #healthcare #hormonalimbalance" Click to Tweet Study Comparing Immunoassay and Mass Spectrometry Measurements A study published in The Journal of Clinical Endocrinology & Metabolism aimed to compare the accuracy of immunoassay-based estradiol tests with mass spectrometry measurements among middle-aged and older male subjects participating in various population-based studies. This comparison was essential for understanding the limitations of traditional methods like ECLIA when measuring serum estradiol levels, particularly in men. Moderate Correlation Between Testing Methods The study found that, within each cohort, serum E2 levels obtained by immunoassay correlated moderately with those measured by mass spectrometry (MS). However, this moderate correlation does not guarantee equal accuracy between the two methods, especially when measuring low estradiol levels typically found in men, which may influence inflammation-related outcomes. Instead, it highlights a potential discrepancy when using immunoassays for measuring low estradiol levels typically found in men. Influence on Inflammation-Related Outcomes The researchers uncovered a potential issue when utilizing immunoassays to gauge low estradiol concentrations normally found in men - the measurements were affected by C-reactive protein (CRP) or CRP-related components, potentially interfering with analysis. This means that previous association studies between immunoassay E2 levels and inflammation-related outcomes might need reevaluation due to this potential interference. This discovery further emphasizes the importance of using sensitive liquid chromatography-tandem mass spectrometry (LC/MS)-based assays for accurate measurement of serum estradiol levels in males. By opting for LC/MS technology over outdated methods like standard assays alone, healthcare professionals can ensure optimal results without fail while monitoring hormone management or testosterone replacement therapy among their patients experiencing issues like fatigue or erectile dysfunction resulting from imbalanced hormones like estrogen (estradiol). This research has revealed a moderate association between immunoassay and mass spectrometry measurements, with potential ramifications for inflammatory effects. Moving on to the next heading, we will explore how these findings can be used to improve hormone management and testosterone replacement therapy monitoring. "Accurate estradiol testing is crucial for hormone management. A study shows LC/MS-based assays provide optimal results compared to outdated immunoassay methods." #hormonemanagement #estradioltesting Click to Tweet Implications for Hormone Management and Testosterone Replacement Therapy Monitoring Accurate estradiol testing plays a significant role in hormone management and testosterone replacement therapy (TRT) monitoring. Men enduring signs such as exhaustion, low libido, or impotence may reap rewards from TRT to restore hormone balance. However, it is crucial to monitor estradiol levels alongside testosterone levels during treatment to ensure optimal results. The sensitive LC/MS-based estradiol test for males offered by DiscountedLabs.com provides several advantages over traditional immunoassay tests: Better sensitivity and specificity: The LC/MS method accurately measures lower concentrations of estradiol typically found in men, ensuring precise evaluation of hormonal imbalances. No interference from CRP or associated factors: Unlike immunoassays that can be influenced by C-reactive protein (CRP), the LC/MS assay eliminates potential interferences for more reliable results. Incorporating accurate estradiol testing into hormone management strategies helps healthcare professionals make informed decisions regarding treatment plans. To ensure proper hormone balance, physicians may adjust TRT dosage or prescribe an aromatase inhibitor if a patient's estrogen levels are too high. To learn more about how accurate estradiol testing can improve your health journey and support effective hormone management practices, visit our blog post demonstrating its importance among men seeking optimal hormonal balance. "Optimize your hormone management with accurate estradiol testing from Discounted Labs. Ensure precise evaluation of hormonal imbalances for optimal results. #HormoneManagement #TRT" Click to Tweet Frequently Asked Questions Accurate Estradiol Testing What is the most accurate way to test estrogen levels? The most accurate method for testing estrogen levels, specifically estradiol, is liquid chromatography-tandem mass spectrometry (LC/MS). This technique offers improved sensitivity and specificity compared to immunoassay-based tests. Studies have shown that LC/MS provides more reliable results in both males and females. Are estrogen tests accurate? Estrogen tests can be accurate, depending on the method used. At lower concentration ranges, immunoassay-based tests are less reliable and may be subject to interference from C-reactive protein (CRP). However, sensitive LC/MS methods offer greater accuracy due to their enhanced sensitivity and reduced influence from CRP or associated factors. Can estradiol test wrong? Estradiol tests can sometimes produce inaccurate results if using an immunoassay-based method, especially in males with low concentrations of estradiol. The presence of CRP or other interfering substances may also affect the accuracy of these tests. Opting for a sensitive LC/MS test reduces the likelihood of erroneous results. What is the best estradiol test? The best estradiol test is one that uses liquid chromatography-tandem mass spectrometry (LC/MS), as it offers superior sensitivity and specificity compared to traditional immunoassays. This makes it particularly suitable for accurately measuring low concentrations of estradiol in males undergoing hormone management or testosterone replacement therapy monitoring. What day is best to test estradiol? For women, the best day to test estradiol depends on their menstrual cycle. In general, it is recommended to test estradiol levels during the follicular phase of the cycle (days 2-4). For men and postmenopausal women, there are no specific days for testing; however, consistency in timing can help monitor changes over time. Conclusion Accurate estradiol testing is essential for monitoring hormone management and testosterone replacement therapy in males. The results of a recent study comparing immunoassay-based tests to LC/MS measurements demonstrate that the latter are far more sensitive, reliable, and accurate. Therefore, it is recommended that all men undergoing hormone management or testosterone replacement therapy use an LC/MS test when checking their estradiol levels. Accurate data is essential to enable informed decisions regarding medical care, so LC/MS testing should be employed when evaluating estradiol levels in men undergoing hormone therapy or testosterone replacement. Take control of your health today and get an accurate estradiol test from Discounted Labs. With our convenient, affordable services, you can easily access lab tests without the need for a doctor's visit.  

  We are going to review a few simple steps you can take to maintain the health of your prostate gland. So, if you're like most men, you have a general idea of where your prostate is located, but you may be a little unfamiliar with what its function is. So, the prostate gland's primary function is to aid male fertility by secreting liquid ejaculate rich in fructose that nourishes and protects sperm. As men age, the prostate gland can become problematic because it can start to grow. And the urethra, which runs down from the bladder through the prostate gland and out the penis for urination, can become restricted from this prostate growth. And, of course, prostate growth can make it difficult to urinate. This enlargement of the prostate gland is called benign prostatic hyperplasia or BPH for short. It can affect around 25% of men by the age of 40. Unfortunately, this number increases exponentially as men age, and by the time they reach 70 years old, around 80% of men are affected by BPH. Table of Contents What is BPH and What Causes it? How Can BPH Be Treated? Side Effects of BPH Drugs How to Prevent BPH Are There Any Supplements Taken for BPH? What Prostate Exams Do Doctors Perform for BPH? Prior to a PSA Test: Don’t Do These Activities Don’t forget to tell your doctor if you are going to get a PSA test: What is BPH and What Causes it? BPH isn't a life-threatening condition, but it can be pretty aggravating living with the symptoms daily. And in some cases, it can be so debilitating that it requires a trip to the emergency room for surgery. The two leading causes of BPH are hormonal imbalances and inflammation in the body. So, when it comes to hormones, the main culprit is the antigenic hormone dihydrotestosterone or DHT for short. Now, this is a derivative of testosterone that is made via the 5-alpha reductase enzyme. So as men age, the levels of this enzyme increase, which increasingly converts your testosterone into the more potent dihydrotestosterone. A little DHT is important for men's health, especially when it comes to sexual function, but too much can cause growth of the prostate gland and male pattern baldness. Inflammation is another cause of BPH. And for most men, this is caused by a processed diet and a diet rich in omega six vegetable oils. Some omega-six fatty acids are essential for our health, but when levels rise too high in the body, it can drive inflammation.   How Can BPH Be Treated?  In rare cases, inflammation of the prostate gland, which is called prostatitis, is caused by a bacterial infection. So, of course, this needs to be tested and treated by your doctor with antibiotics. Now, conventional treatment of BPH is typically a prescription of a class of drugs called 5-alpha reductase inhibitors. As the name suggests, these drugs prevent the conversion of testosterone into dihydrotestosterone by suppressing the 5-alpha reductase enzyme. Now, these drugs are quite effective in reducing growth of the prostate gland, and studies have shown that they reduce the prostate gland by up to 25%.   Side Effects of BPH Drugs Unfortunately, there is a downside to taking these drugs. Some  patients suffer serious sexual side effects. These side effects include loss of sex drive, erectile dysfunction, inability to ejaculate, and penile and testis tissue shrinkage. So many of these side effects can be reversed when stopping the medication, but there are rare cases of men who stop the medication and still experience these sexual side effects for years after the fact. So, you have to consider seriously before going on these drugs by talking to your physician and your pharmacist. Now, if you'd like to avoid the potential side effects of these drugs, there are some more natural treatments that you can try first.   How to Prevent BPH A recent study found that men classified as clinically obese men were three and a half times more likely to develop BPH than men of average weight. This study suggests a direct correlation between body fat percentage and developing prostate problems later on in life. So, one of the simplest things you can do to try and prevent BPH and maintain the health of your prostate gland is to lose body fat. And you can do this by hiring a personal trainer or a nutritionist to work on your exercise and nutrition to lose body fat and build lean muscle.   Are There Any Supplements Taken for BPH? In terms of taking supplements to support your prostate health, the two that some experts recommend saw palmetto and zinc. These both have proven efficacy in research studies and clinical observations when it comes to maintaining the health of the prostate gland in aging men. So saw palmetto is derived from a wild plant rich in fatty acid and phytosterols that are healthy for the prostate gland. And in fact, saw palmetto has been the most widely used natural treatment for BPH in North America since the 1800s. Saw Palmetto works comparably to the 5-alpha reductase inhibitors in terms of partially blocking the 5-alpha reductase enzyme that converts testosterone into dihydrotestosterone. However, it's not as powerful as the drugs, so there's less potential for side effects. One study found that participants had a 50% reduction in BPH symptoms after eight weeks on high dose saw palmetto supplementation. The standard amount is 320 milligrams of saw palmetto per day until your symptoms subside. Zinc is an essential trace mineral that is important for male health, especially regarding fertility and immune function. A recent study on zinc and prostate health shows that 140 of 200 men gain complete relief of their BPH symptoms after 16 weeks on high-dose zinc supplementation. So, the standard dose of zinc supplementation to treat BPH is 80 milligrams per day until your symptoms subside, and then reduce it down to 40 milligrams per day as a maintenance dose. A word of caution with high-dose zinc supplementation, anything over 100 milligrams per day can suppress your immune system. And there is some evidence that zinc can contribute to prostate cancer. So, make sure to only stick to the 80 milligrams per day until your symptoms go away and then reduce it down to the 40 milligrams. Also, high-dose zinc supplementation can drive down copper stores in the body, and copper is essential for health because it aids red blood cell production and also immune function. So, take two to three milligrams of copper along with your high-dose zinc to balance them out.   What Prostate Exams Do Doctors Perform for BPH? Your doctor may determine that a digital rectal exam (DRE) is useful in evaluating your prostate health. The prostate is just in front of the rectum. For this test, your doctor will gently insert a lubricated, gloved finger into your rectum to examine the prostate for irregularities in size, shape, and texture. He or she will also order a PSA test. Prostate Specific Antigen (PSA) is produced exclusively by cells of the prostate gland. Used in conjunction with the digital rectal examination, PSA is a useful screening test for benign prostate enlargement, prostatitis and prostate cancer development. There are some things a man should not do before having a PSA test. This list of “don’ts” will help ensure your test results are as accurate as possible.   Prior to a PSA Test: Don’t Do These Activities Participate in vigorous exercise and activities that stimulate or “jostle” the prostate, such as bike riding, motorcycling, and riding a horse, ATV, or tractor, or getting a prostatic massage for 48 hours before your test. Participate in sexual activity that involves ejaculation for 48 hours before your test. Ejaculation within this time frame may affect PSA results, especially in younger men. Schedule your PSA test to be done for at least six weeks after undergoing any of the following procedures: prostate biopsy, transurethral resection of the prostate (TURP) for BPH, urethral catheter, cystoscopy, or any other procedure that involves the prostate. If you are in doubt about the possible impact of any procedure on your PSA test, talk to your doctor. Schedule a PSA test if you have a urinary tract infection. A bacterial infection in the urinary tract can cause PSA levels to rise temporarily. If you are not sure if you have a urinary tract infection, have a urine test before your PSA test to make sure. If you do have a urinary tract infection, you should wait at least six weeks after you have completed your antibiotic treatment before you have your PSA test. Schedule a digital rectal examination (DRE) before your PSA test. Although a DRE should not have an impact on PSA levels, having the PSA test first is a precaution. Don’t forget to tell your doctor if you are going to get a PSA test: If you undergoing chemotherapy, as these drugs can cause an elevated PSA level If you are taking any medications, especially statins, nonsteroidal anti-inflammatory drugs, or medications that control urinary problems such as dustasteride or finasteride. All of these substances have the potential to affect PSA levels. If you have undergone urinary tract or prostate surgery recently, or if you have suffered a pelvic injury or sports injury. If you have prostatitis or BPH. Why Your High PSA Test May Not Be Prostate Cancer   Get a PSA Test from Discounted Labs at a lab near you with no doctor visit required.

Testosterone replacement therapy (TRT) is becoming increasingly popular in the United States and worldwide. It provides a safe, scientific treatment option for men who have low testosterone levels. In the US alone, almost 5 million men are hypogonadal (have low testosterone) and most males over 65 have testosterone levels below normal values. TRT doesn't only increase your testosterone levels, it can also provide other benefits, particularly to those who are obese and struggle with type 2 diabetes. Keep reading to discover a few studies that back up the idea that testosterone replacement therapy can improve your diabetes symptoms. Table of Contents Discovering the Effects of TRT on Men with Fatty Liver (NAFLD) Study 1 - TRT Improves NAFLD Grade in Obese Men Study 2 - Long Term TRT Improves Lipid Profile in Men Study 3 - Effects of TRT on Body Measurements Study 4 - TRT Effects on Diabetic Patients Expand Your TRT Knowledge References: Discovering the Effects of TRT on Men with Fatty Liver (NAFLD) Non-alcoholic fatty liver disease (NAFLD) is a liver inflammation that could advance to life-threatening conditions if left untreated. This type of disease is caused by various factors and not by drinking too much alcohol. NAFLD is characterized by an accumulation of fat and toxins around the liver. This restricts blood circulation to this organ and prevents it from doing its job properly. NAFLD usually has little to no symptoms and could advance to liver cirrhosis and even liver cancer. One of the main reasons people develop NAFLD is poor diet. Junk food in combination with a sedentary lifestyle could cause NAFLD in men of all ages. With that being said, studies have shown that long-term administration of exogenous testosterone could improve NAFLD and prevent it from advancing to more dangerous stages. Study 1 - TRT Improves NAFLD Grade in Obese Men For example, a study done on 55 obese men shows how beneficial TRT can be for people with non-alcoholic fatty liver disease. This study was performed over 2 years. All 55 men had testosterone test to prove that they had functional hypogonadism and were diagnosed with type 2 diabetes. The 55 patients were split into two groups. The first group of 28 men was given 1000mg of testosterone undecanoate every 3 months for two consecutive years. The second group contained 27 patients who received a placebo for the first year and 1000mg of testosterone undecanoate for the second year. This was a comprehensive study that looked at multiple parameters and important health signs. For example, both total and free testosterone levels were measured at the beginning and the end of the study. Other important measurements taken were fasting glucose, HDL, LDL, triglycerides, blood count, creatinine, electrolytes, liver enzymes, and more. After two years, the testosterone levels for all 55 men showed impressive changes. The administration of 1000mg of testosterone undecanoate normalized testosterone levels in both groups. Liver measurements also revealed that NAFLD grade was improved and patients no longer experienced significant symptoms associated with this type of liver infection. The improvements began immediately after starting TRT. Another impressive finding is that no side effects were observed as a result of administering TRT for 2 years. The patients didn't experience cardiovascular damage or prostate carcinoma. They report having more energy and self-confidence as a result of taking TRT. This study basically concludes that 1000mg of testosterone undecanoate might be enough to quell the symptoms of low testosterone in men. Additionally, it can reduce NAFLD grade and prevent major liver complications that could be life-threatening. Additionally, the medication adherence was 100% for all study participants. They received testosterone injections in a clinical setting and under medical supervision. Study 2 - Long Term TRT Improves Lipid Profile in Men Let's take a look at another study that reflects how beneficial TRT might be on overweight or obese men who struggle with low testosterone levels. A 12-year study analyzed the lipid profiles of 723 who were diagnosed with hypogonadism. These patients were either overweight or obese. Losing weight seems to be a problem especially in the United States. Carrying extra pounds of fat can lead to multiple life-threatening cardiovascular diseases, not to mention that it can augment some of the symptoms of hypogonadism. Luckily, some studies show that the administration of exogenous testosterone might be able to reduce the amount of fat hypogonadal men carry. This works best when coupled with healthy changes in diet and adhering to basic exercise regimens. In most cases, a short-term administration of testosterone usually lowers HDL levels. HDL is the "good cholesterol" while LDL is the "bad" one. However, more recent studies on long-term administration of testosterone undecanoate might have an inverse reaction. It can improve the lipid profile of patients and increase the levels of HDL. The group of 723 men who participated in this study was split into two categories. The first group contained 367 men and they received 1000mg of testosterone undecanoate for 12 weeks, followed by a pause of 6 weeks. This is the T group. The second group included 356 men and they received no exogenous testosterone. This is called the Control group. All lipid measurements were done before starting the administration of testosterone. For example, the measurements looked at a lipid panel including HDL, LDL, other cholesterol particles, triglycerides, waist circumference, etc. These patients were tested a few times per year and their lipid profile was recorded for comparison. These tests were done over 12 years. The results were clearly advantageous for the testosterone group. For example, HDL cholesterol increased significantly in the T group and decreased in the Control group. The LDL cholesterol decreased in the T group and increased in the Control group. Triglycerides were also measured and they increased in the Control group and significantly decreased in the T group. These results were seen consistently and the adherence to medication is 100%. All testosterone undecanoate injections were administered in a clinical setting under the strict supervision of a medical professional. In conclusion, long-term TRT can improve the lipid profile of overweight or obese men who also struggle with hypogonadism. It will also normalize testosterone levels and bring other benefits to a man's quality of life such as increased libido, more stamina, etc. Study 3 - Effects of TRT on Body Measurements Anthropometric parameters refer to measurements of the human body, particularly dimensions and shape. It's a science that looks at the particular measurements of an individual concerning other individuals in the same group. For example, it tackles waist size and circumference, length of feet, arms, height, weight, and more. This type of information is useful in various industries and fields. For example, experts in ergonomics and clothes designing need to know the general body measurements of individuals to create better and more efficient products and services. At the same time, anthropometric parameters need to be studied in relation to weight loss/gain as a result of following fitness programs or TRT protocols. This helps medical professionals come up with improvements and adjustments to help patients achieve their desired body shape, composition, and body mass index (BMI.) Multiple studies show that long-term administration of testosterone undecanoate can help improve anthropometric parameters in men with hypogonadism. For example, a 12-year study performed on hundreds of hypogonadal and obese men proves this fact. 476 men with low testosterone levels and obesity were selected for this long-term study. Their body measurements, dimensions, and shapes were recorded at the beginning of the study. This data was also updated with each visit for more than 12 years in a row. 281 men decided to receive 1000mg of testosterone undecanoate for 12 weeks, followed by a pause of 6 weeks. 195 men decided not to take exogenous testosterone and they were part of the control group. Some of the measurements recorded by medical experts were age, height, weight, waist circumference, BMI, fasting glucose, blood lipids, and more. A special emphasis was put on anthropometric measurements since this was the purpose of the study. The study results are impressive. Waist circumference decreased in the group who received testosterone undecanoate and increased in the control group. Weight decreased in the group who received exogenous testosterone and increased for patients who weren't on TRT. The BMI also decreased for the testosterone group and increased slightly for the control group. The waist-height ratio decreased for those who took testosterone and increased for the control group. Visceral adiposity is a parameter that measures the amount of visceral fat in a person. Visceral fat is a type of fat that envelops the organs. It's one of the most dangerous types of fats since it can promote the accumulation of toxins and reduce organ function. In the testosterone group, visceral adiposity decreased. It increased for the control group. In conclusion, the group who received testosterone undecanoate frequently experienced major improvements in anthropometric measurements. Apart from having higher testosterone levels after 12 years of TRT, they achieved better body composition and increased libido. It's important to note that medication adherence was also 100%. All testosterone injections were administered in a clinical setting, similar to the other studies mentioned in this article. Study 4 - TRT Effects on Diabetic Patients Type 2 diabetes mellitus is a prevalent and life-threatening disease. Almost 50% of hypogonadal men experience problems with processing sugar or are diagnosed with type 2 diabetes. This type of disease can be controlled with medicine, but it causes other health complications and decreases the quality of life. Luckily, multiple studies start to reveal the benefits of testosterone therapy for people with diabetes. Administering exogenous testosterone seems to improve the health of the patients, particularly their ability to process sugar. The positive results are best seen in long-term studies. For example, a 12-yearlong study performed on 865 men shows how a frequent administration of testosterone undecanoate can improve glycemic control, diabetes tests and the symptoms of type 2 diabetes. 361 of these men were previously diagnosed with type 2 diabetes. 183 of them received a regular dose of 1000mg testosterone undecanoate for 12 weeks. 178 men decided not to take exogenous testosterone. All of the study participants had documented low levels of testosterone and many of them were also obese. Multiple parameters were measured for the study participants such as their glucose levels, waist circumference, blood pressure, and more. These measurements were done at the beginning of the study and on a regular basis for 12 years. The study findings are clearly advantageous for the group that received testosterone. For example, glycemic control improved significantly for those on TRT. This means that the participants received less and less insulin or anti-diabetes medications to stabilize their glucose levels. On the other hand, 22 patients from the control group started taking insulin during the 12 years. Fasting glucose and A1c also decreased in the testosterone group and increased for those who decided against TRT. Another important finding is that weight and waist circumference decreased for the testosterone group while increased for the control one. This is another proof that TRT can improve anthropometric measurements in hypogonadal and obese men who struggle with type 2 diabetes. Since all the testosterone injections were administered in a clinical setting, it's impossible to ignore the validity and impressive findings of this study. This prompts more health experts to look at the potential benefits of long-term testosterone for hypogonadal men. On top of that, the combination of lifestyle changes coupled with a frequent administration of testosterone undecanoate might be able to reduce the mortality rate in hypogonadal men. Some of these lifestyle changes involve physical exercises and a clean diet, free of junk and processed foods. Interestingly, pre-diabetics who follow a TRT protocol might also experience significant improvements in their blood glucose levels. This means that it might be possible to prevent diabetes altogether by administering the right amount of testosterone to individuals who need it. Expand Your TRT Knowledge Although there is much to be learned about testosterone and TRT in general, there is a significant body of evidence available online for those who want to learn more. For example, the Excelmale.com Forum contains hundreds of answers to questions about testosterone. This TRT forum is backed up by scientific studies and it can help you learn more about why some men have low testosterone levels and how they can mitigate this problem. You can get answers to your questions from experienced medical doctors, healthcare professionals, and TRT patients who have followed testosterone protocols for years.   References:   1- Endocrine Abstracts (2021) 73 PEP7.1 2- Endocrine Abstracts (2021) 73 AEP162 3- Endocrine Abstracts (2021) 73 AEP162 4- Endocrine Abstracts (2021) 73 OC2.3    

Testosterone Replacement Therapy (TRT) has changed the lives of many men around the world.  Like any therapy, it can have great benefits if properly managed but negative side effects if not monitored.  This article will briefly and simply review the different TRT tests that most physicians use to monitor your progress while minimizing potential side effects.   Table of Contents How to Know if You Need TRT Follow Up Lab Tests After Starting TRT Avoiding or Lowering High Hematocrit on TRT Avoiding Low Ferritin and Iron Monitoring the PSA Test on Testosterone Monitoring Estradiol Test on Testosterone Avoiding High Blood Pressure and Water Retention on TRT Monitoring Kidney Function Avoiding High Liver Enzymes Monitoring Thyroid Tests Maintaining Good HDL Levels on TRT Prolactin in Men with Low Testosterone: The Forgotten Hormone Where to Buy Your Own TRT Tests: How to Know if You Need TRT The first thing doctors actually measure before you get on testosterone replacement is your total and free testosterone blood levels to find out if you have low testosterone. They will also ask you a few questions to see if you have low testosterone or hypogonadal symptoms. They include low sex drive, erectile dysfunction, fatigue, low mood, and issues with cognitive capacity and function. So, testosterone replacement therapy includes anything to increase testosterone levels with either injections or creams, gels, pellets, oral, nasal, and other TRT options. Follow Up Lab Tests After Starting TRT Once you get on testosterone replacement, your doctor will have you come back either at week six or eight to run another blood test to see if your dosage needs to be adjusted and/or you may require other medications to monitor or to modulate or change levels like estradiol, hematocrit, etc. The first one obviously is testosterone total and free. You come back at week six or eight, and your total testosterone is not over 500 nanograms per deciliter, your doctor will probably choose to increase your dosage or your frequency of injections in the case of injections. Free testosterone is usually around 2% of total or higher. If you have lower than 2%, your doctor will probably focus on any issues related to high sex hormone binding globulin (SHBG), which is a protein that binds to testosterone and does not free it up for action. Avoiding or Lowering High Hematocrit on TRT Hematocrit is the proportion of red blood cells in the blood. Testosterone tends to increase red blood cells.  Some men don't have that issue, but most men at least have a two to a three-point increase in hematocrit after starting TRT. Hematocrit increases a lot more in men on TRT who have sleep apnea and in smokers since these two can cause oxygen starvation.  High hematocrit can increase the viscosity of the blood and may cause cardiovascular issues. So, the magic number to go for is a hematocrit of 53 or below. When you're getting close to 53, you have to basically donate blood or go for what we call a therapeutic phlebotomy to bring down the red blood cell amount in the blood. And that's very important because as hematocrit goes up, your blood becomes more and more viscous, and your cardiovascular system gets compromised.  It's also very important not to let it go too high because above 52, most blood centers would not accept you as a donor, so you would have to require a special prescription for a therapeutic phlebotomy from your doctor for the blood centers to take your blood and dispose of it later. Keep in mind that donating more frequently than every three months may decrease your ferritin and iron stores considerably, which can cause fatigue and other issues. Here are some hematocrit lab panels, or you can buy them as part of the CBC panel. Avoiding Low Ferritin and Iron When your hematocrit is over 53, and you donate blood frequently than every three months, you can deplete your iron stores which makes you tired, depressed, and with no libido. Blood donations should not be happening that frequently because you'll lose iron. Some doctors will test your iron and your ferritin, and if you have low levels, they will put you on an iron supplement. Discounted Labs sells a blood donation panel that is designed to inform you if you can safely donate blood. Monitoring the PSA Test on Testosterone High PSA, prostate-specific antigen, is the only contraindication for testosterone replacement therapy if it is 4 or above. Obviously, physicians get very concerned that a man with higher PSA may have prostatic cancer, although it could be caused by an infection of your prostate (prostatitis) that could be easily treatable with an antibiotic. So, all high PSA tests do not mean you have cancer, but it could mean that you could have a treatable prostatic infection.  Your doctor may prescribe antibiotics and retest your PSA after your antibiotic cycle is finished.  He or she may need to refer you to a urologist if your high PSA test does not come down.  But if you do have a PSA of four or higher, you are not going to be allowed to use testosterone replacement unless your doctor can actually prove that it's an infection that will eventually be treated so that your PSA can come down. Monitoring Estradiol Test on Testosterone Estradiol (E2) is a very important hormone for men. We need it because estradiol is actually linked to bone health, cognitive functioning, cardiovascular health, even sex drive, and decreased fat mass. Having very low estradiol of under 20 pg/mL is actually not good for you since it can decrease bone density and cause other issues. Having very high estradiol in relation to your testosterone blood level may also have some consequences.  Several studies have different opinions and conclusions on what high estradiol means. About 0.3 to 0.4% of testosterone gets converted into estradiol by the aromatase enzyme. So obviously, the body increases the amount of estradiol as your testosterone goes up. There's nothing wrong with that. Estradiol balances testosterone to keep a better lipid (cholesterol) profile and to keep healthy sperm counts, just to name a few benefits. But what level of estradiol in men is too high? For example, if you have a testosterone level after you start TRT of 700 nanograms per deciliter, obviously, your estradiol is going to be higher than when before you started TRT. Is that cause for concern? Most men on testosterone replacement therapy do not need to take medications to lower estradiol. Estrogen blocker medications like anastrozole (Arimidex) are being overprescribed by many TRT clinics.  Men with a history of gynecomastia or breast enlargement may have issues with gynecomastia again if your estradiol's over 50 pg/ml, but in most studies where men with gynecomastia were followed, a lot of those men had low testosterone while they had high estradiol. A large study in adolescent boys showed that most of the ones with gynecomastia also had high IGF-1.  Some studies have shown that the ratio of testosterone to estradiol is really the important factor to monitor, with ratios over 12 being needed for healthy sperm production in men. But the management of estradiol in men is a very controversial topic as there is not a lot of agreement in the field.  Some doctors insist on keeping an E2 level of 20 to 40 picograms per milliliter no matter how high testosterone levels reach. We have learned in the past three years that the old immunoassay-based estradiol test tends to overestimate estradiol in men. Two studies have shown that the real estradiol value is better tested with a liquid chromatography-mass spectrometry sensitive estradiol assay. So, make sure that if your doctor is going to check your estradiol, you're using the right LC/MS E2 test. Discounted Labs offers several lab panels that contain sensitive estradiol.  Another concern of high estradiol is that some men feel that water retention is an issue, although that has not been proven by any studies. Most men with TRT-related water retention assume that their estradiol is high but fail to get it tested. Avoiding High Blood Pressure and Water Retention on TRT Some men on testosterone replacement therapy tend to have increased blood pressure related to water retention. There are some central nervous system effects that increase blood pressure and heart rate. These men can gain considerable weight during the first weeks of TRT.  Most lose most of that weight after a few weeks of therapy.  Some studies have shown that testosterone may decrease sodium excretion by the kidneys, which makes the body retain water to keep that sodium diluted. Ways to improve blood pressure are to lose weight, take a blood pressure medication, exercise, and decrease excessive sodium intake. Many men assume that their estradiol is high when they experience water retention. That assumption has not proven to be correct. Monitoring Kidney Function The estimated glomerular filtration rate, or eGFR, is a way to measure your kidney function. It's part of what we call a CMP blood test panel, and we are aiming at an eGFR over 60. Anything below that is indicative of a slowdown in the way your kidneys are filtrating toxins from your body. TRT does not really cause a decrease in eGFR. However, a lot of men taking creatine, exercising heavily, or eating very high protein intake tend to probably have artificial increases in creatine that decrease eGFR. You can Google eGFR formula and see how that's calculated. Avoiding High Liver Enzymes Current testosterone replacement therapy options have not been shown to increase liver enzymes; only the old oral forms of TRT used to cause that problem. However, doctors obviously follow it up. A very important distinction to make is that men that are exercising heavily with weights at the gym may artificially  increase in AST and ALT that has nothing to do with toxicity to the liver. Monitoring Thyroid Tests TSH, thyroid stimulating hormone, is also something else that most doctors follow up, although some actually do not. Low thyroid function (hypothyroidism or high TSH) may have the same symptoms as low testosterone. TRT medical guidelines groups around the world recommend different schedules for monitoring men on TRT, and a few of them agree with each other. Rarely do any guidelines mention thyroid function monitoring in men on TRT. TSH levels above 2.5 may indicate that you have hypothyroidism. If you have high TSH, doctors usually tend to use a comprehensive thyroid panel that includes free T3 and free T4, along with antibodies, to see if you have an autoimmune disease like Hashimoto's that may be inducing hypothyroidism. Maintaining Good HDL Levels on TRT High-density lipoprotein or HDL is another one of the variables most affected by testosterone replacement, especially at higher doses. When I say higher doses, anybody using 200 milligrams of testosterone replacement per week — cypionate or enanthate — tend to have a lowering of HDL. Low HDL has been shown to cause cardiovascular issues, so your doctor will always follow your lipids. Testosterone replacement has not really been shown to increase LDL, and there are some studies that show that TRT improves triglyceride blood levels because testosterone tends to improve the way the body metabolizes carbohydrates. There's very little we can do to increase HDL besides aerobic exercise, losing weight, decreasing TRT dose, and taking a supplement. Niacin supplementation is one of the ways to increase HDL, but some people get flushing of the skin and face. Last but not least, the use of anastrozole, an estradiol blocker, can also decrease HDL since estradiol is known to protect HDL levels. Prolactin in Men with Low Testosterone: The Forgotten Hormone Prolactin is not a hormone that is usually measured at TRT baseline or even at follow-up unless you have severe erectile dysfunction, even with good levels of testosterone. Men that have low testosterone at baseline, and I mean low testosterone, very low — under 150 nanograms per deciliter — are probably the best candidates to get a prolactin test. It is a hormone that women and men produce – obviously, women that are lactating produce it at higher concentrations in their bodies because it helps lactation. It also has some other benefits; otherwise, men would not have it. Prolactin has some immune-enhancing benefits and some cardiovascular benefits that are starting to show up in studies. So, prolactin is not an evil hormone, but it can, at higher concentrations, cause erectile dysfunction. The reason for high prolactin could be a benign tumor called pituitary adenoma (diagnosed by MRI), which can be producing a lot of pituitary output for prolactin, and that could actually impair your testosterone replacement therapy benefits. So, it's a hormone that is hardly looked at unless you are a man that has very low testosterone blood levels at baseline or do not respond well (unresponsive erectile dysfunction) after eight weeks or ten weeks of testosterone replacement therapy and/or you are having high prolactin symptoms, like lactation. That's actually a very rare symptom that actually occurs in men with pituitary adenomas. Where to Buy Your Own TRT Tests: DiscountedLabs.com provides very low-cost blood testing in most US states. You don't need to see a doctor because the company has in-house physicians that provide a prescription. After ordering your lab test online, you receive an email with the lab request form that you take to the closest lab near you. Once you go to a lab and get your blood drawn, you receive an email with your results within five to seven business days, depending on the blood test. For more information, visit DiscountedLabs.com   Visit ExcelMale.com to download Nelson's latest book: Beyond Testosterone   Click here for TRT Resources

Table of Contents Lab Test Results Turn-Around Time How to Locate a Lab Near You What Lab Tests Require Fasting? Stay Hydrated Before Lab Test Best Time of Day to Get Lab Test Done Taking your Medications Before Lab Tests Important Information for those on Hormone Replacement Therapy and Your Lab Tests Why DiscountedLabs.com? After you buy your lab tests online with Discounted Labs, there are things you should do to get ready for your blood draw at the nearest lab near you.  Here are a few considerations to know so that your lab test results are accurate. Lab Test Results Turn-Around Time All lab test orders are processed Monday to Friday 9 am-5 pm Central Time. Results for commonly ordered tests are typically available within 3 business days after collection at a patient service center. Specialized tests based on LC/MS assay could take 5 to 7 business days to get results.   How to Locate a Lab Near You After receiving and printing your lab requisition form, please take it into any Quest location along with a photo ID.  Quest Diagnostics lab centers are typically open during business hours Mon-Friday,. with some locations open Saturdays. No appointment is necessary, but you can schedule an appointment. Scheduling an appointment may save wait time if the lab is busy. No additional charges will be required. Find a lab near you.   What Lab Tests Require Fasting? Fasting is usually recommended for common tests like glucose and lipid profiles. Some physicians prefer that testosterone testing be done before breakfast since food may temporarily decrease the blood level of testosterone. If you ordered a lipid (cholesterol) panel or a testosterone blood test (and are not currently on testosterone replacement therapy), it is recommended that you fast for at least 8 hours before getting your blood drawn in the morning at the location you choose. The following panels required fasting: 12 hours - CMP (14), Lipid Panels, Renal Function Panel 8 to 10 hours - Insulin, Cardio IQ Advanced Lipid Panel, CBC ( Glucose), GGT 6 to 8 hours - B12, Folate, magnesium, Homocysteine   Stay Hydrated Before Lab Test Hydration is of the utmost importance. Drink extra water for 24 hours prior to your draw, and try refrain from drinking alcohol for 24 hours prior to collection. Dehydration decreases blood volume that could result in higher lab test values.   Best Time of Day to Get Lab Test Done Depending on your current treatment and your doctor's reason for testing, there may be an optimal time of day at which the test should be completed. Be sure to follow your doctor's instructions for your laboratory tests. Having labs taken early morning is recommended for the following tests: ACTH Glucose Plasma PTH Testosterone (if not on TRT)   Taking your Medications Before Lab Tests Take your medications prior to your appointment. However, if you have diabetes and are on oral medications or insulin, check with your doctor whether to take these medications. See below for special instructions for hormone replacement medications.   Important Information for those on Hormone Replacement Therapy and Your Lab Tests If you are on hormone replacement of any type, please be sure to have your labs drawn BEFORE your hormone cream application or hours before your next testosterone injection.   For more information: Fasting Labs and Blood Tests - Everything You Need to Know Testosterone Tests: Should They Be Done After Fasting? Factors that Can Affect the Accuracy of Your Blood Test Results Biotin May Interfere With Hormone Blood Tests   Why DiscountedLabs.com? We Have the Most Affordable Lab Tests Available in the U.S. No Doctor Visit is Required. Our In-House Doctor Provides Prescription at No extra Cost to You. We Serve Several U.S. States. No Hidden Costs. A $8 Lab Draw Fee is Added to Your Order. Our Blood Tests are FDA Approved. We are HIPAA Compliant. We Protect Your Privacy. Your Order Good for 90 Days. You Do Not Have to Rush to the Lab. Over 1,900 Lab Locations Around the United States. No Appointment Needed. Walk-ins Welcomed. Your Blood Test Results are Delivered by Email. We Provide Hormone Testing Via Sensitive Assays. We Have Created Blood Test Panels Applied to Different Needs. Discount Coupons Emailed Periodically. Educational Videos and Articles are Provided in Our Blog Page.

Table of Contents Check Out the Most Important Blood Tests for Seniors Lipids Panel Comprehensive Metabolic Panel Complete Blood Count Thyroid Test Panel A1c Test PSA Test Find Out More About Your Health Today! References: Check Out the Most Important Blood Tests for Seniors   You might be happy to find out that direct-to-consumer blood tests have become so affordable and accessible these days that it's a pity not to take advantage of them. This is particularly important for seniors because they are exposed to more health issues in comparison with younger generations. Fortunately, this article gives you a shortlist of some of the most important blood tests most physicians order for senior patients in follow up visits. These tests give you a great overview when it comes to your general health and based on the test results, you will know exactly what to do next. Let's find out more about these tests. Lipids Panel The lipid panel is a battery of tests that looks at how well your body metabolizes fat and whether you're at risk for coronary artery disease. As you already know, cholesterol is a waxy substance made by your liver. It lines the insides of your blood vessels, making them more elastic and adding protection. Unfortunately, too much cholesterol can cause blockages and blood clots. This is where the lipid panel can help. It shows you an accurate snapshot when it comes to the levels of cholesterol in your blood. Also, the lipid panel looks at your triglycerides, HDL, and LDL cholesterol as well as other important lipids.  Certain foods can raise your cholesterol levels and having a sedentary lifestyle can also increase the chances of having unhealthy cholesterol levels. Some people may also have a genetic predisposition to high lipids due to family history. A lipids panel test can let you know exactly where you stand when it comes to cholesterol and triglycerides. Comprehensive Metabolic Panel You might be happy to find out that the Comprehensive Metabolic Panel is an inexpensive collection of 14 tests that check your protein levels, electrolyte, and fluid balance and more. It also looks at some important liver and kidney enzymes, so you will know right away if these important organs work correctly. For example, some of the substances tested by the CMP are calcium, potassium, albumin, aspartate transaminase, creatinine, and others. Based on the results, your doctor might suggest minor lifestyle and diet changes or further investigations to prevent more complicated health problems. Complete Blood Count The CBC panel looks at the numerous components of the blood such as red blood cells, white blood cells, platelets and more. It's important to have accurate information about these components because they might reveal if you're struggling with known health problems such as anemia, autoimmune diseases and so on. The CBC panel is paramount for older adults as part of the annual health checkup. Best of all, it doesn't cost a lot of money and you can do it in conjunction with other test panels such as lipid or metabolic panels. The results are emailed to you in just a few business days and your primary healthcare provider can help you interpret them. Thyroid Test Panel Unbelievably, the thyroid gland situated at the base of your neck is the source of your daily energy levels. Its hormones impact most of the organs and bodily processes, so if something goes wrong, you will feel fatigued and your body temperature might get low. As part of the thyroid blood test, the panel looks at some of the most important thyroid hormones such as T3 and T4. If your thyroid hormones are not balanced properly, you might feel certain symptoms such as sensitivity to heat, nervousness, chronic fatigue, and others. If you have these symptoms, you should test your thyroid hormones and see what treatment options are appropriate for you. Some thyroid ailments can easily be mitigated with proper medications, but you need to know your thyroid's hormonal profile before starting a thyroid treatment. A1c Test This test is not as popular as the others, but equally important. The A1c is also known as glycated hemoglobin. The levels of A1c go up in the body when glucose starts to combine with the red blood cells. This usually happens when the blood sugar levels are very high for a couple of months in a row. As you know already, having high blood sugar levels predisposes you to one of the most dangerous chronic diseases - type 2 diabetes. A simple blood glucose test can tell if you're pre-diabetic or your blood sugar levels are within normal ranges. However, A1c can stay in the blood for up to 3 months and this tells you that your blood sugar levels have been high for a long time. It's a more accurate test for some people and it lets you know if you should immediately do something to lower your blood sugar levels to prevent diabetes. PSA Test On top of the aforementioned tests, seniors should also consider doing a PSA test. This stands for prostate-specific antigen and it's a biomarker of prostate inflammation. The prostate can get inflamed for assorted reasons and people of an elderly age are more vulnerable to various prostate diseases. For example, benign prostate hyperplasia, bacterial prostatitis and even prostate cancer are among the numerous illnesses related to the male prostate. A simple PSA test can reveal if your PSA levels are within normal ranges or not. If these levels are high and you also have some specific symptoms, you should consider doing further investigations to find out more about your prostate's health. Painful urination as well as urinating with interruption are among the most common symptoms of prostate inflammation. Find Out More About Your Health Today! As the saying goes, "An ounce of prevention is worth a pound of cure". This is especially true when it comes to your health. Therefore, do your best to order these blood tests annually to keep your health in check. These tests are not only highly recommended to only adults, but to younger generations as well. At the same time, you can have most of them in a simple package from reputable vendors. For example, go to DiscountedLabs.com and order the Annual Physical Lab Test Panel. This panel contains everything you need to get a comprehensive snapshot of your health!   ====================== References: Top 10 Blood Tests for Older Adults: What to Know A1c- Hemoglobin (Hgb) Comprehensive Metabolic Panel (CMP) - Medical Tests    

Table of Contents High hematocrit: the main side effect of Testosterone Replacement Therapy (TRT) What are the symptoms of high hematocrit? What are factors that increase the risks of TRT polycythemia ? How to Lower Hematocrit? How to Manage Increased Hematocrit Caused by Testosterone Replacement Therapy High hematocrit: the main side effect of Testosterone Replacement Therapy (TRT) Testosterone replacement therapy (TRT) is one of the most effective ways to combat low testosterone levels, but it's vital that you understand the risks associated with the treatment. As with any form of hormone replacement therapy, there are a few downsides to receiving regular injections of testosterone. But do these risks outweigh the benefits? That's a decision you'll have to make for yourself! Note: Remember the purpose of TRT: to restore testosterone to NORMAL, healthy levels in the body. Ideally, testosterone levels should be normal after TRT. Even at normal levels, there is a risk of side effects. One of the primary risks of testosterone that is you need to be aware of is called polycythemia. This is a condition where your body produces too many red blood cells, also known as high hematocrit level. Hematocrit refers to the red blood cell content in your blood. If your hematocrit levels rise, your blood will become too thick or viscous. This can, in turn, make it more likely that you will develop strokes, heart attacks, and clotting events. Polycythemia is serious and potentially life-threatening if untreated.   What are the symptoms of high hematocrit? In recent years, there has been an increased association between TRT and polycythemia. With TRT becoming a more mainstream treatment, more people are experiencing the symptoms of polycythemia, which include: Weakness Fatigue Headache Itching redness of the skin bruising joint pain dizziness abdominal pain shortness of breath breathing difficulty when you lie down numbness, tingling, or burning in the hands, feet, arms or legs Turning very red or "flushing" after workout When polycythemia occurs, the blood becomes very thick. But instead of being able to carry MORE oxygen, the increase of red blood cells can be dangerous. The risk of clotting increases as a result of the red blood cell count increase. Note: While there is a risk of hematocrit increase, there is no proof that TRT increases the risk of clotting events. It's vital to be aware of the potential risk, so doctors need to be careful when prescribing TRT to men with high hematocrit levels, red blood cell disorders, and obstructive pulmonary disease. All of these things increase the risk of clotting events as a result of the hematocrit increase caused by TRT.   What are factors that increase the risks of TRT polycythemia ? There are a number of factors that can increase your risk of developing this problem. According to Dr. Michael Scally, polycythemia "occurs quite frequently in people who are on replacement testosterone." Age also plays a role in your polycythemia risk. Young men are far less likely to experience this problem than older men. The mode of delivery and the dose of testosterone affect the increase in your hematocrit levels. Men who receive formulations of pharmacokinetically steady-state delivery hormones are far less likely to develop the problem than men who receive intramuscular injections of testosterone. Topical preparations only cause the problem in up to 20% of cases. 5 to 15% of those who use testosterone patches develop polycythemia, while 10 to 20% of those using the testosterone gel develop the problem. Of course, the amount of testosterone delivered per day (50 to 100 milligrams) also affects the risk of developing polycythemia. Testosterone injections may increase hematocrit more than gels, patches, pellets, nasal or oral testosterone formulations.  Smaller injection doses given more frequently may increase hematocrit less rapidly than larger dose injections, but data are lacking to prove that fact. Men with sleep apnea or those who smoke are at the highest risk of high hematocrit since their bodies are trying to compensate for the decreased oxygen level by producing more red blood cells.  TRT enhances that red blood cell production.   How to Lower Hematocrit? So what can you do about the problem? Is there any way to manage it? Those undergoing TRT must be aware that polycythemia is a real risk, as do their doctors. They must keep a close eye on their hemoglobin and hematocrit levels. If hematocrit rises above 52%, further examinations may be necessary. Some doctors counsel reducing or stopping testosterone treatment. However, for those who are undergoing TRT as a means of restoring healthy hormone levels, this may not be an option. Some means of managing and reducing the risk of high hematocrit levels include: Scaling back on the amount of testosterone gel delivered per day (50mg or less) or injection dose. Changing the method of administration (using more frequent injections with smaller doses, or using a testosterone gel or cream) Making sure that you are hydrated when you get your blood drawn for lab tests Stopping smoking Getting sleep apnea diagnosed and treated with a CPAP machine to enhance oxygen saturation levels when sleeping. If these options do not work, a therapeutic phlebotomy (blood donation) may be the answer. Removing just one unit of blood can help to lower hematocrit by as much as 3%. For those with very high hematocrit levels, the therapy may continue for months, gradually reducing hematocrit to safe levels over time. Some physicians even prescribe regular phlebotomies (no more frequently that every 56 days is the safe frequency to avoid iron loss) as a means of preventing overly high hematocrit levels. While phlebotomies are not covered by your insurance, they can be performed at any blood bank. Even if your insurance company won't cover the cost, you can solve the problem by donating blood (provided you are free of hepatitis, HIV, and other blood-borne infections). Experts agree that donating every 2.5 to 3 months is safe, and it's a good way to keep your hematocrit levels under control. It is important to note that hematocrit can stabilize in men on longer term TRT, so many men do not have to donate blood after a few months on TRT. Warning: Donating more than 1 unit of blood more frequently than every 2.5 months can lower your iron and ferritin levels. This can cause fatigue. Make sure to replace the lost iron with a supplement in order to prevent anemia. You can check your iron and ferritin with this iron blood test. It's recommended that you donate when you are in the 51-52% hematocrit range. However, some organizations (like the Red Cross) will reject blood with a hematocrit higher than 53%, so it is good to avoid that hematocrit high level if you want to donate blood. Hematocrit is included in the CBC and other panels: Get Your Hematocrit Test Now Testosterone, Hematocrit, Ultrasensitive Estradiol and Prolactin Panel Hematocrit + Total and Free Testosterone   To find out more information, click  How to Manage Increased Hematocrit Caused by Testosterone Replacement Therapy

Estradiol is the most important female sex hormone, and it plays a significant role in developing female secondary sexual characteristics. It also plays a vital role in maintaining proper bone density, regulating body fat, and ensuring a strong erection in men. This type of hormone is one of the three estrogens found in the human body. The other two are called estrone and estriol. Estradiol is the most important and strongest of the estrogen hormones, and it is primarily made in testicles, fat cells, and liver. Approximately 80% of the estradiol found in a man's body comes from the aromatization of testosterone. A small amount of testosterone is converted to estradiol to maintain healthy reproductive and cognitive systems in men, among other body functions. Why is estradiol in men important? Because maintaining proper estradiol levels is paramount for ensuring the correct functioning of various body processes. For example, estradiol is involved in: · Maintaining correct HDL cholesterol levels · Improving penile sensitivity · Maintaining an emotional balance in men · Promoting high bone density There are numerous myths that circulate online when it comes to estradiol. Since this is a female sex hormone, some say that too much estradiol can give one "man boobs" or make him asexual. Although having very high estradiol levels can lead to various health issues, reducing the amount of estradiol in the body can also have negative consequences such as losing bone mass, having joint pains or having a decreased libido. Keep reading this article to learn more about estradiol and how it can negatively affect the body if it circulates in the blood in sub-optimal quantities.   Estradiol in Men Studies Maintaining optimum estradiol levels is key to flourishing health and enhanced fitness performance. There are several causes or factors which might disrupt proper estradiol balance and lead to very high or very low estradiol levels. · Various medications such as HIV meds, etc · Toxins from the environment · Various foods · Age · High Body Mass Index (BMI) To achieve correct estradiol levels in the organism, one needs to learn more about this type of hormone and find out how it influences the body. The following study analyzes how testosterone and estradiol can influence muscle development, strength and sexual function in men aged 20-50. Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men Study Purpose This study aims to identify a direct relationship between testosterone and estradiol in men and various body functions and processes such as fat accumulation, muscle development, and fitness performance, libido, and sex drive, etc. Approximately 80% of the estradiol currently found in men results from the aromatization of testosterone. When if the levels of testosterone go down, estradiol levels will also be reduced, and this might lead to changes in body composition. Study methods Two groups of 198 and 202 men participated in this study. They were healthy men aged 20-50 who were carefully monitored for over 16 weeks to find differences in body composition and fitness performance. The first 198 men were given goserelin acetate which is a substance that suppresses natural testosterone and estradiol levels. They were also given a placebo gel as well as testosterone gel in different concentrations such as 1.25 g, 2.5 g, 5 g, or 10 g. The gel was administered daily. The second group received the same treatment, but they were also given an aromatase inhibitor which is a substance that prevents the aromatization of testosterone into estradiol. Study conclusions Key factors were monitored in these 400 men to determine the influence of testosterone and estradiol on muscle performance and strength, sex drive, and fat development. The study concluded that the body fat percentage increased in men who received a placebo testosterone gel or 1.25 g or 2.5 g of testosterone gel without getting anastrozole. Lean muscle mass also decreased in these men, and leg-press strength showed a significant decrease only in men who received the placebo gel. The significant increases in body fat are attributed to estrogen deficiency (suppression of the aromatization process of testosterone). Both androgen and estrogen deficiency caused a significant decrease in sexual function which was represented by sexual desire and erectile function. Men who received the placebo gel or 1.25 g of testosterone gel experienced the most significant decrease in sexual function, as opposed to those who received a higher concentration of testosterone gel. The study was funded by the National Institutes of Health and determined that decreases in testosterone levels primarily influence muscle strength and performance, decreases in estradiol can lead to a higher subcutaneous and intraabdominal fat percentages, and both androgen and estrogen deficiencies can lead to poor sexual function. Let's take a look at more negative consequences which can appear as a result of having too little estradiol in the body. Why low estrogen levels are dangerous for health and decrease fitness performance As mentioned earlier, having less-than-optimal amounts of estrogen in the body can lead to multiple health problems in men of all ages. Let's discover how low estradiol levels can hinder fitness goals or affect health. 1. Low estrogen levels prevent the translocation of Glut-4. Muscle hypertrophy is essential for fitness professionals and the protein carrier Glut-4 can help with recovery and growth by transporting nutrients from the surface to the core of the cells. However, this protein can sometimes become stubborn and remain inactive for long periods of time. As a result, insufficient amounts of nutrients are carried from the surface to the interior of the cells which might make the muscle recovery process less efficient. The role of estrogen, in this case, is to make the translocation of the Glut-4 possible which leads to a higher amount of nutrients being delivered to muscle tissues for repair and growth. Having very low amounts of estrogen can prevent the activation of this protein carrier which is a significant loss for any fitness professional or bodybuilder. 2. Low estrogen levels allow myostatin to interfere with the muscle-building process. As you probably already know, myostatin is an important suppressor of muscle growth in both males and females. It can be extremely powerful as presented in various studies and experiments performed on animals. For example, animals which had their myostatin gene removed experienced dramatic increases in muscle mass, sometimes reaching up to 100% more muscle in comparison with animals which haven’t been genetically altered. Studies show that the elevated estrogen levels in women can prevent myostatin from interfering with the muscle-building process. By having very low levels of estrogen, the myostatin substance is free to suppress muscle growth which is something all fitness professionals want to avoid. 3. Low estrogen levels can worsen insulin resistance. Insulin, a substance produced by the pancreas, is essential for "unlocking" cells in the bloodstream, allowing them to absorb the existing glucose – a process which gives the human body energy to survive and to perform daily tasks. When cells develop insulin resistance (as a result of a sedentary lifestyle, among other factors), type 2 diabetes can result. Doctor Evelyn Yu, M.D., an endocrinologist at the Harvard University, concluded that estrogen deficiency could lead to a poor glycemic index as well as an increased resistance to insulin. Men and women of all ages can be affected by this, and that’s why it's important never to reduce the estrogen hormone to a dangerous level. Another study conducted on men aged 40-74 years determined the important role of high aromatase activity in the body. Let's take a closer look at its findings. High Aromatase Activity in Men with Low Testosterone Is Associated with Higher Spine BMD, Increased Truncal Fat Mass and Reduced Lean Mass Study Purpose This study strives to determine a relationship between spine BMD (bone mineral density) and aromatase activity in patients with low testosterone levels. Study Methods 90 men aged 40-74 years were carefully monitored during a genetic study on the effects of the aromatase enzyme on the bone mineral density. These men underwent testosterone replacement therapy as a result of low testosterone levels. Their body composition was analyzed using advanced tools such as dual-energy x-ray machines and enzyme immunoassay, among other medical equipment. Study Conclusions The study concluded that men who had the highest estradiol levels in comparison with testosterone also registered the highest spine bone mineral density. At the same time, their high aromatase activity leads to an increase in truncal fat as well as a significant decrease in lean body mass. The most important finding of this study is that despite having low circulating testosterone levels, high aromatase activity can lead to healthy musculoskeletal health in men over 40 years old. The direct relationship between estradiol and high bone density is visible in this study. Summary The role of estradiol in men's health cannot be denied. There are numerous benefits this hormone can provide to men of all ages if it circulates in the blood in optimal quantities. This article is part of a series of documents which outline important findings of scientific studies on estradiol. The more information one accumulates on estradiol, the better decisions he can make when it comes to achieving healthy estrogen levels in the body. One of the best ways to determine how much estradiol one has in his body is by using blood tests. This is an inexpensive and highly efficient method of knowing the exact estrogen and testosterone levels. Do you have any questions? Do you know more about estradiol or want to provide feedback? Use the comment section below to ask your questions about estradiol or share your knowledge with everyone!   More interesting reading: THE TOP 18 THINGS YOU DID NOT KNOW ABOUT ESTRADIOL'S ROLE IN MEN'S HEALTH