TBG lab test

Low T3: Thyroid Hormones and Reverse T3 What is the Thyroid? The thyroid is a small, butterfly-shaped endocrine gland in the lower front of the neck, just below the Adam’s apple. Despite its size, the thyroid has a big job to regulate many bodily functions, including metabolism, growth, and development. This gland produces two main hormones, triiodothyronine (T3) and thyroxine (T4), which are necessary for overall health and well-being. By releasing these hormones into the bloodstream, the thyroid helps your body use energy so every cell can function properly. Thyroid Functions The thyroid is a butterfly-shaped endocrine gland about 2 inches long and is located in the front of your neck below your Adam’s apple. The thyroid has a big job in growth and metabolism by releasing the hormones thyroxine, or T4, and triiodothyronine, or T3, which regulate your body’s ability to convert calories and oxygen into energy. The hypothalamus in your brain produces thyrotropin-releasing hormone, or TRH, which stimulates the release of thyroid-stimulating hormone, or TSH, from your pituitary gland. TSH then travels to your thyroid and tells it to release T4 and T3 into your bloodstream. Under normal conditions, your thyroid produces about 80% T4 and 20% T3 with T3 being 4 times more potent than T4. Keeping T3 and T4 in the normal range is essential for thyroid function and overall health. Every cell in your body has receptors for thyroid hormones that affect your cardiovascular system, bone metabolism, protein synthesis, body temperature regulation, cholesterol production, glucose metabolism, cognitive function, and your gastrointestinal tract. 20 million Americans have some form of thyroid disorder, and women are more affected than men. Thyroid Hormones Thyroid hormones, T3 and T4 are produced by the thyroid gland and are necessary for many bodily functions. T3 is the more active form of thyroid hormone and T4 is converted to T3 in the liver and other tissues. T3 tests are necessary for diagnosing thyroid conditions and understanding T3 levels. These hormones regulate metabolism, heart rate, body temperature and muscle strength. Thyroid hormones are also critical for growth and development especially in children and adolescents for proper physical and cognitive development. What are normal T3 levels? Normal T3 levels are measured in nanograms per deciliter (ng/dL) of blood. The normal range for T3 levels varies among labs but generally is 80-180 ng/dL for adults. For children it’s 100-200 ng/dL. Check your lab report for the reference range, as values can vary slightly among labs. Low T3 Levels: Low T3 levels can mean an underactive thyroid, or hypothyroidism. This is when the thyroid gland doesn’t produce enough thyroid hormones, including T3. Low T3 levels can also be caused by starvation, certain medications, and severe illness. Symptoms of low T3 levels are fatigue, weight gain, dry skin, hair loss, and cold intolerance. In some cases low T3 levels can be a sign of a more serious condition like thyroid cancer or liver disease. High T3 Levels: High T3 levels can mean an overactive thyroid, or hyperthyroidism. This is when the thyroid gland produces too much thyroid hormone, including T3. High T3 levels can also be caused by thyroid nodules, thyroiditis, and certain medications. Symptoms of high T3 levels are weight loss, increased appetite, rapid or irregular heartbeat, fatigue, heat intolerance, and mood changes. In severe cases, high T3 levels can cause a life-threatening condition called thyroid storm. What is Hypothyroidism and Symptoms and T3 Levels? Hypothyroidism is the most common thyroid disorder, characterized by fatigue, weight gain, constipation, hair loss, dry skin, cold intolerance, irregular menstruation, depression, muscle pain, and cognitive impairment. Hypothyroidism is an underactive thyroid gland that doesn’t produce enough hormones for optimal metabolic function. The most common cause of hypothyroidism is Hashimoto’s thyroiditis, which is an autoimmune disorder where the body produces antibodies that attack and destroy thyroid gland tissue. Other causes of hypothyroidism are iodine deficiency, pituitary tumor, radiation therapy on your face, neck, or chest; pregnancy and childbirth; aging; and underconversion of T4 to T3 due to inflammation, stress, selenium deficiency, and overexposure to fluoride, chlorine, or mercury. Liver disease can also affect thyroid function and T3 levels. If you’re experiencing any of the symptoms of hypothyroidism, you should ask your doctor to order blood tests that include TSH, free T4, free T3, reverse T3, and thyroid antibodies if he or she suspects Hashimoto’s. When interpreted correctly, lab results can help determine the underlying cause of your thyroid dysfunction and the right clinical interventions. What is Reverse T3 and T3 Test? Reverse T3 is often excluded by doctors when ordering lab tests for hypothyroidism because they think reverse T3 is an inactive metabolite with no physiological effect on the body. Not addressing reverse T3 has left many patients suffering from hypothyroidism despite their other lab tests coming back within normal range. A T3 test is important in diagnosing thyroid conditions and understanding T3 levels, as it helps to interpret thyroid health comprehensively. But reverse T3 does play a role in metabolic function when your body is under extreme stress by acting as an emergency brake to conserve energy. Under normal conditions, T4 is converted into the more active T3 that binds to cellular receptors all over your body to exert powerful metabolic effects. Reverse T3 is also produced to clear out excess T4 from your body when not needed. But when reverse T3 levels rise too high, it blocks the uptake of active T3 by binding to cell receptors, and the end result is a slowing down of metabolism. According to the National Academy of Hypothyroidism, in a normal thyroid, about 40% of T4 is converted to T3, and 20% is converted to reverse T3 daily. But if your thyroid is malfunctioning or your body needs to conserve energy and is under significant stress, the conversion ratio can change to 50% of T4 becoming reverse T3. A big change like that can impact thyroid function and hormone availability. If you have normal TSH, T4, and T3 but high reverse T3, you will still experience many symptoms of slow metabolism like weight gain, fatigue, depression, constipation, and chronic pain. To determine how T3 and reverse T3 are functioning at a cellular level, you need to calculate your free T3 to reverse T3 ratio by dividing the two numbers from your lab results. For example, if your free T3 is 325 and your reverse T3 is 26, then you just divide 325 by 26, which is 12.5. A healthy T3 to reverse T3 ratio should be above 20. So 12.5 would mean subclinical hypothyroidism. If a doctor prescribes synthetic thyroid medication like levothyroxine to a patient with subclinical hypothyroidism, it can worsen their condition because the T4 in the medication will continue to cause an increase in reverse T3. Thyroid Function Tests Thyroid function tests are important tools in diagnosing and monitoring thyroid disorders like hypothyroidism (underactive thyroid) and hyperthyroidism (overactive thyroid). These tests measure the levels of thyroid hormones in the blood to assess thyroid gland function. The most common thyroid function tests are: Thyroid-stimulating hormone (TSH) test: This test measures the level of TSH, which stimulates the thyroid gland to produce thyroid hormones. Free T3 (FT3) test: This test measures the level of free T3 in the blood. Free T4 (FT4) test: This test measures the level of free T4 in the blood. Thyroid antibody tests: These tests measure the level of antibodies against thyroid cell proteins, which can indicate autoimmune thyroid disorders. Thyroid function testing includes other assessments like radioactive iodine uptake tests to diagnose hyperthyroidism or hypothyroidism. By looking at the results of these tests, healthcare providers can diagnose thyroid conditions and create a treatment plan to get thyroid function back to normal. Non-Blood Tests for Thyroid Function Besides blood tests, there are several non-blood tests that can be used to evaluate thyroid function. These tests are: Radioactive iodine uptake (RAIU) tests: These tests measure the amount of iodine taken up by the thyroid gland. High uptake means hyperthyroidism, and low uptake means hypothyroidism. Thyroid scans: These tests use a small amount of radioactive iodine to create an image of the thyroid gland. This can help identify any abnormalities in the gland, like nodules or cancer. Ultrasound: This test uses high-frequency sound waves to create an image of the thyroid gland. This can help identify any abnormalities in the gland, like nodules or cancer. Thyroid Antibody Tests Thyroid antibody tests are used to diagnose autoimmune thyroid diseases like Hashimoto’s thyroiditis and Graves’ disease. These tests measure the level of antibodies against thyroid cell proteins in the blood. The most common thyroid antibody tests are: Thyroid peroxidase (TPO) antibodies: These antibodies are present in most people with Hashimoto’s thyroiditis. Thyroglobulin (Tg) antibodies: These antibodies are present in some people with Hashimoto’s thyroiditis and Graves’ disease. Thyroid-stimulating immunoglobulin (TSI) antibodies: These antibodies are present in people with Graves’ disease. Thyrotropin receptor antibody (TRAb) tests: These tests detect both stimulating and blocking antibodies in Graves’ disease. Remember, thyroid antibody tests are not used to diagnose all thyroid conditions, and a diagnosis of a thyroid condition can only be made by a healthcare provider based on clinical evaluation, laboratory tests, and medical history. How to decrease reverse T3? There are two steps to decrease high Reverse T3: Remove all the factors that are converting T4 into reverse T3. Flush out the remaining Reverse T3 from your body. Factors that can convert T4 into reverse T3 include chronic illnesses like diabetes, fibromyalgia, arthritis, and Lyme disease; low-calorie diet or eating disorders like anorexia; chronic inflammation like autoimmune diseases; insulin resistance or leptin resistance; extreme exercise like marathons, triathlons, or heavy weightlifting; mental/emotional stress like loss of job, divorce, death of a loved one, or PTSD; gastrointestinal infections or imbalances like intestinal dysbiosis, irritable bowel syndrome, yeast overgrowth, or candida; and certain drugs like beta blockers, antidepressants, and diabetic and antiseizure medications. Radioactive iodine uptake tests can help assess thyroid function and diagnose hyperthyroidism. There are also several nutritional supplements that can support your thyroid gland and convert T4 into T3. One is iodine. Your body needs iodine to make thyroid hormones. In 2007, the World Health Organization estimated that 30% of the world’s population is iodine deficient, and infants born to mothers with hypothyroidism are at risk of learning and developmental delays. The recommended intake of iodine is 1-2 milligrams a day. The second is selenium. The thyroid gland has the highest concentration of selenium by weight of any organ in the body. Selenium is needed to form the enzymes that convert T4 into active T3. As an antioxidant, selenium also protects thyroid tissue from oxidative stress. The recommended intake of selenium is 200-400 micrograms a day. The third is zinc. Optimal zinc helps convert T4 into active T3 and lowers reverse T3. One study showed that when patients with normal T4, low T3 and high reverse T3 were given zinc supplements for 12 months, their T3 levels normalized and reverse T3 went back to normal. The recommended intake of zinc is 30-60 milligrams a day. Once you have addressed your T4 conversion issue, under the guidance of your healthcare provider, you can flush out the excess reverse T3 from your body with bioidentical T3 hormones like Cytomel or compounded and sustained-release T3. T3 cannot be converted into reverse T3 so as you slowly increase your T3 with medication, your T4 and reverse T3 will both go down. T3 medication dose is 5-25 micrograms daily on an empty stomach first thing in the morning. Be patient; it can take 8-12 weeks to feel better as the reverse T3 is flushed out of your system. Side effects can be anxiety, heart palpitations, nausea, and headaches. Work with your doctor to find the right T3 dose for you. GET YOUR THYROID TESTS HERE Thyroid Health Tips Thyroid health is key to overall health. Here’s how to keep your thyroid gland working optimally: Eat well: Include foods high in iodine, like seafood, dairy, and iodized salt, to support hormone production. Exercise: Regular physical activity helps thyroid function and overall health. Manage stress: Stress can harm thyroid function, so manage stress through meditation and yoga. Sleep well: Sleep is key to thyroid function and overall health. Avoid toxins: Some toxins, like pesticides and heavy metals, can affect thyroid function, so minimize exposure. Thyroid health can be affected by many factors, including genetics, age, and certain medical conditions. If you have thyroid concerns, see your healthcare provider, who can do thyroid function tests and give you personalized advice to keep your thyroid healthy. Bibliography  Thyroid Hormones Overview - NCBI Bookshelf What Is Reverse T3? - HealthCentral Research on Reverse T3 - PubMed Overview of the Thyroid Gland - Merck Manuals Understanding Reverse T3 Syndrome - Neuroendocrinology Society Reverse T3 and Its Role in Thyroid Health - Niki Cleuet Blog Thyroid Hormone Production and Function - ColumbiaDoctors Overview of Reverse T3 - Verywell Health Reverse T3 in Clinical Practice - Cleveland Clinic Journal of Medicine Thyroid Hormone: Production, Function, and Regulation - Cleveland Clinic Understanding Reverse T3 and Thyroid Dysfunction - Elixir Naturopathy Reverse T3: Key Insights - Paloma Health The Role of Thyroid Hormones: An Intricate Dance - Revolution Health  

Are you curious about the Igra Test? If so, you're in the right place. In this blog, we'll uncover all the essential information and insights about the Igra Test that you need to know. We'll delve into Interferon-Gamma Release Assays (IGRAs) and help you understand what they are. You'll learn about the mechanisms behind IGRAs, including how they work, their advantages, and their limitations. We'll also walk you through the process of administering an IGRA Test, step by step. Plus, we'll decode the IGRA test results and explain how to interpret them. Additionally, we'll explore different scenarios for IGRA Test use and discuss why companies and the US Immigration Service require an IGRA test. Finally, we'll provide pre- and post-IGRA test guidelines to help you prepare for the test and know what to expect afterward. So let's dive in and get all your questions answered! Delving into Interferon-Gamma Release Assays (IGRAs) Interferon-Gamma Release Assays (IGRAs) are diagnostic tests used for detecting tuberculosis (TB) infection. These tests work by measuring the immune response to specific antigens produced by Mycobacterium tuberculosis, the bacteria that causes TB. Because IGRAs are more precise and are unaffected by the BCG vaccine or the majority of nontuberculous mycobacteria, they are superior to other tests. They play a crucial role in diagnosing mycobacterium tuberculosis infection, including latent tuberculosis infection (LTBI), especially in individuals at higher risk, such as those with HIV or recent exposure to TB. Different types of IGRAs, like Quantiferon and T-SPOT.TB, have applications in clinical practice, providing valuable insights for healthcare providers regarding TB diagnosis and management. Understanding the interpretation and significance of IGRA test results is essential for accurate patient evaluation and appropriate intervention, making interferon-γ release assays an important tool in the fight against TB. Understanding the IGRA Test to detect tuberculosis An important way to find people who might still have tuberculosis is to do the IGRA test, also known as the interferon-gamma release assay. This blood test checks for the release of interferon-gamma in response to TB-specific antigens and is considered more specific than the tuberculin skin test. Unlike the skin test, the IGRA test does not cross-react with BCG or smallpox vaccinations. With just a single patient visit, the IGRA test provides results within 24-48 hours, making it a convenient option for individuals at high risk of TB exposure. This includes healthcare workers and those who have recently immigrated from countries with a high burden of TB. By understanding the IGRA test and its role in the diagnosis of tuberculosis, we can effectively identify and manage latent TB infections. The Mechanism behind IGRAs Interferon-Gamma Release Assays (IGRAs) are a type of blood test used to detect tuberculosis (TB) infection. They work by measuring the release of interferon-gamma, an immune reaction, when exposed to specific TB antigens, including ppd. This test offers several advantages over other TB testing methods. It is more specific than the tuberculin skin test (TST) and does not cross-react with the BCG vaccine, providing reliable results. The process of conducting an IGRA test involves collecting fresh blood samples and stimulating them with TB antigens. The results are then interpreted as either positive or negative for TB infection in any part of the body. However, IGRAs also have limitations and challenges, including false-positive results in patients with non-TB mycobacterial infections or immunosuppression. Despite these challenges, IGRAs play a crucial role in the diagnosis and control of TB, offering valuable insights for effective TB testing and management strategies. How does it work? The IGRA test detects tuberculosis infection by measuring the immune response to specific antigens. A small blood sample is mixed with TB antigens, and if the person has been exposed to TB, their immune system will produce a measurable reaction. Advantages and Limitations of IGRAs IGRAs offer distinct advantages over the tuberculin skin test (TST). They have higher specificity and sensitivity, leading to more accurate results, particularly in detecting latent tuberculosis infections. Another benefit is that IGRAs can detect both latent and active tuberculosis (TB) infections, providing comprehensive diagnostic capabilities. Additionally, IGRAs require only one patient visit and provide quicker test results compared to the TST. Unlike the skin test, IGRAs are unaffected by prior BCG vaccination, ensuring accurate results. However, it's essential to note that IGRAs have limitations in certain populations, such as immunocompromised individuals, which may affect their accuracy. Overall, IGRAs offer higher accuracy and a more comprehensive approach to diagnosing tuberculosis, making them a valuable tool in healthcare. The Process of Administering an IGRA Test The process of administering an IGRA test involves collecting a blood sample from the individual and stimulating the immune system to release interferon-gamma. This diagnostic test, which stands for Interferon-Gamma Release Assay, is used to detect latent tuberculosis infection. The collected blood sample is then analyzed in a laboratory to measure the amount of interferon-gamma released by T cells, a type of white blood cell that plays a crucial role in the body's immune system. This indicates the presence of a TB infection. Compared to traditional tuberculin skin tests, IGRA tests are considered more accurate and reliable. The results of the IGRA test can help healthcare professionals determine if further testing or treatment is necessary for the individual. Steps Involved in IGRA Testing The process of IGRA testing involves several steps. A health care professional first takes a blood sample from the patient. This blood sample is then sent to a laboratory for analysis. In the lab, the blood sample is exposed to specific antigens that stimulate an immune response. After an incubation period, the level of immune response is measured using specialized equipment. The results of the IGRA test, which can help diagnose tuberculosis infection, are typically available within a few days. By following these steps, healthcare professionals can gather valuable information about a patient's tuberculosis status. Decoding IGRA test results: Can a BCG vaccine affect results? The IGRA test, or Interferon-Gamma Release Assay, is a diagnostic test used to detect tuberculosis (TB) infection. It helps healthcare professionals interpret the results of the test, which can be positive, negative, or indeterminate, including a positive igra test. Factors such as the presence of HIV, BCG vaccination, and the progression from latent TB infection to active TB disease can affect the accuracy of the IGRA test results, leading to false-positive results. If you receive a positive or indeterminate IGRA test result, further testing and evaluation may be necessary. Compared to other tuberculosis diagnostic tests, the IGRA test has its advantages and limitations. How to Interpret IGRA Test Results Interpreting IGRA test results involves analyzing the immune responses to tuberculosis (TB) antigens. A positive result suggests a TB infection, while a negative result indicates no infection or early stages. Indeterminate results require further evaluation to determine the presence of TB bacteria. Scenarios for IGRA Test Use The IGRA test, also known as the interferon gamma release assay, is widely used for tuberculosis (TB) infection detection. Healthcare providers utilize the IGRA test to screen individuals at high risk for TB. It is often combined with other diagnostic methods, like the tuberculin skin test (TST). The IGRA test helps determine if a person has been exposed to TB bacteria and if treatment is needed. Particularly, it is valuable for individuals who have received the BCG vaccine, as it can differentiate between vaccine-related immunity and active TB infection. By assessing various scenarios, the IGRA test plays a crucial role in identifying and managing TB infections. Who should consider getting an IGRA test? Considering an IGRA test? It's recommended for those exposed to TB or at high risk of contracting it, as stated in the package insert for many biologics. This includes healthcare workers, individuals with weakened immune systems, and those in close quarters with someone with TB. Also used to screen for latent TB infection before immunosuppressive therapy. Talk to your healthcare provider to determine if an IGRA test is right for you. Quest, a leading provider of medical tests, offers a Tuberculosis Blood Test for those who suspect they have been exposed to the disease or need evidence of a negative TB test. The company's test is also beneficial for individuals residing in high-risk areas for TB. The first test measures how much IFN-γ is made in response to ESAT-6 and CFP-10 antigens from Mycobacterium tuberculosis, as stated in the package insert for the test. These antigens are different from those found in BCG and most other mycobacteria that are not tuberculous. Why do companies and the US immigration service require an IGRA TB test? Companies and the US Immigration Service require IGRA tests to screen for tuberculosis (TB) infection, an infectious disease, in the United States. TB is a contagious disease that poses a risk to public health. The IGRA test helps identify individuals exposed to Mycobacterium tuberculosis and at risk of developing tuberculosis disease, ensuring the safety of employees, customers, and the public. Pre- and Post-IGRA Test Guidelines Pre- and Post-IGRA Test Guidelines: To ensure accurate results, it's important to follow certain guidelines before and after undergoing an IGRA test. Before the test, it's crucial to understand the purpose of the IGRA test, which is often recommended for individuals who have been exposed to tuberculosis (TB) or are at high risk of contracting TB. Pre-test guidelines include avoiding medications or substances that may affect the test results, as well as considering the potential adverse effects of TB treatment. During the test, be prepared for a blood test to detect the immune response to specific TB antigens. After the test, it's essential to interpret the results correctly and take any necessary follow-up steps. It's also important to consider the limitations and potential risks associated with the IGRA test, including the possibility of a false negative test result. Preparing for the IGRA Test When preparing for the IGRA test, it is important to follow certain guidelines. If applicable, fasting requirements should be adhered to before taking the test. Inform your healthcare provider about any medications you are currently taking. Before the test, avoid smoking or using any tobacco products, as they can potentially affect the results. It is recommended to wear loose-fitting clothing to allow easy access to the arm for blood sample collection. Additionally, staying hydrated by drinking plenty of water before the IGRA test is essential. By following these preparations, you can ensure accurate and reliable results. What should I expect after the test? After completing the Igra test, expect your results in a few days. Positive results may require further medical evaluation for tuberculosis. Negative results indicate no infection or an inactive infection. Follow up with a healthcare professional for next steps or treatment recommendations. How do you interpret IGRA test results? Interpreting IGRA test results involves measuring interferon-gamma (IFN-g) levels. A positive result suggests exposure to tuberculosis (TB), but not active TB disease. A negative result indicates no current TB infection or an inability to mount an immune response. Intermediate or indeterminate results may require further testing or clinical evaluation. How does the IGRA Test Impact Clinical Decisions? The IGRA test plays a crucial role in clinical decision-making for tuberculosis (TB). It helps healthcare providers determine the need for further testing or treatment by identifying TB infection through the presence of tuberculosis bacteria and assessing the risk of active TB disease. The results, along with other clinical information, guide healthcare providers in making informed decisions. Is the Quantiferon Gold Plus Test the Same as an IGRA Test or a TST? The Quantiferon Gold Plus Test is indeed a type of IGRA (Interferon-Gamma Release Assay) test, used to detect tuberculosis infection by measuring the immune response to TB antigens. It is an updated version of the original Quantiferon Gold Test and offers high accuracy and advantages over traditional tuberculin skin tests (TST). This makes it an essential screening test for patients who are about to begin biologic treatment or other forms of immunosuppressive therapy. What Happens If Your IGRA Test Results Are Positive? If your IGRA test results are positive, it means you have been exposed to the bacteria that cause tuberculosis (TB). Further testing, like a chest X-ray, is done to confirm active TB disease. Positive results without active TB may require preventive treatment. Consult a healthcare provider for evaluation and guidance. Where Can You Buy an Affordable IGRA Test Near You? Discounted Labs sells the most affordable IGRA test (Quantiferon Gold Plus) on the market. How Does Discounted Labs Work? 1-   Click on the Lab Near You page to ensure we serve your state and that a location is near you.  2-   If a location is near you, go to Quantiferon Gold Test and add it to the shopping cart.  3-    If you have a discount coupon code, add it to your cart. You will earn points for every purchase you can redeem in future orders. 4-   If you don't have an account with us, you will be asked to create one by adding your name, address, gender, and date of birth. Note: You cannot place an order for someone else unless you create an account for them. 5-   Place your order by using a credit card. 6-    You will receive three emails: an order confirmation & detailed instructions within minutes about how to download your lab requisition form to take to the lab near you. 7-    Print the lab requisition form (PDF file).  8-    Take that form to the  lab near you . You can walk in, but we suggest you make an appointment to cut down on potential waiting (instructions on how to do so are on our "Find a Location" page). Get your blood drawn at the lab.   9-  Your results will be ready within 2-7 business days (Depending on the test. Sensitive hormone tests done by liquid chromatography/mass spectrometry LC/MS take 5-7 business days). You will receive them by email as soon as they come in. Please contact us if you have any questions. We also have answered a lot of questions in our Frequently Asked Questions page More Facts About TB Testing Children less than 2 years old should have the TB skin test instead of the TB blood test. The TB blood test is one of two types of tests used to detect TB. A persistent cough that has lasted for three weeks or longer. A TB blood test takes a single visit to complete, and the test results are typically available within 24 to 48 hours after the blood sample is collected. A small needle is inserted into the vein, and a sample of blood is collected into up to three vials. The results of the TB blood test may be available within 24 to 48 hours after taking the blood sample. Experts recommend testing at least 6 to 8 weeks after exposure to TB. QuantiFERON (QFT) is an interferon-γ release assay (IGRA) that helps check for tuberculosis (TB) infections, whether they are active or latent. The CDC suggests using QFT instead of the tuberculin skin test (TST) in some cases. The QFT has been shown to be more accurate than the TST in identifying people who may have a latent TB infection. A meta-analysis calculated a pooled sensitivity for TST at 70% (23 of 25 studies in developed countries) and a pooled sensitivity for QFT at 84% (13 studies in developed countries). One study reported up to a 32% reduction in cost compared to the TST. If a positive QFT result is the discrete referral decision driver vs. a positive TST (using the data in the study), a QFT positive result might have reduced the chest x-ray referral by 37.5% in the group with no BCG vaccination, who also had a prior TST inoculation history. A QFT positive result might also have reduced the referrals within all study participants by 60% (including the sum of no BCG/no TST history; BCG; and TST/no BCG history participants). Approximately 11 million individuals in the US are currently infected with LTBI, so it is critical for patients to be screened for TB infection prior to the initiation of immunosuppressive treatment, including biologic agents for autoimmune diseases. For such people, an alternative is to assume, without additional testing, that the initial result is a false positive. These tests are mostly developed for the field of tuberculosis diagnosis , but in theory, they may be used in the diagnosis of other diseases that rely on cell-mediated immunity, e.g., cytomegalovirus, leishmaniasis, and COVID-19 . The first test measures how much IFN-γ is made in response to ESAT-6 and CFP-10 antigens from Mycobacterium tuberculosis. These antigens are different from those found in BCG and most other mycobacteria that are not tuberculous. Conclusion In conclusion, the IGRA test is a valuable tool for diagnosing certain infections and conditions. It provides accurate and reliable results that can help guide clinical decisions and treatment plans. Understanding the mechanism behind IGRAs and how to interpret the test results is crucial for healthcare professionals and individuals seeking testing. It is important to follow the pre- and post-test guidelines to ensure accurate results. If you are considering getting an IGRA test, consult with your healthcare provider to determine if it is necessary for your specific situation. Remember, early detection and proper management can make a significant difference in your health outcomes. If you're looking for an affordable IGRA test near you, please visit our website for more information. Citations Centers for Disease Control and Prevention. (n.d.). Testing for TB Infection. Retrieved July 22, 2023, from https://www.cdc.gov/tb/publications/factsheets/testing/igra.htm Gerald, L., Blumberg, H., & Burzynski, J. (2021). Tuberculosis. In: Ferrets, Rabbits, and Rodents (4th ed.). Retrieved July 22, 2023, from https://www.ncbi.nlm.nih.gov/books/NBK560585/ Minnesota Department of Health. (n.d.). Tuberculosis (TB) Facts - Interferon-Gamma Release Assays (IGRAs). Retrieved July 22, 2023, from https://www.health.state.mn.us/diseases/tb/basics/factsheets/igra.html