Testosterone Replacement Monitoring Tests

Top US Locations for Therapeutic Phlebotomy Near Me Understanding Therapeutic Phlebotomies to Lower High Hematocrit What is High Hematocrit? High hematocrit happens when your body makes more blood cells. This makes the blood thicker. When blood is thicker, it is harder for the heart to pump. This can lead to problems like high blood pressure, strokes, and heart attacks. Testosterone Therapy and Hematocrit Levels Testosterone replacement therapy is often used to increase muscle mass and sex drive. It can also raise the production of blood cells and plasma levels. This is good for people with anemia. However, it can increase hematocrit levels, which could be risky. This risk is higher with intramuscular testosterone compared to other methods like patches. Also, factors like smoking can make this issue worse, causing high hematocrit. This condition is known as polycythemia, which means a high red blood cell count (RBC). Preventing and Managing Polycythemia   Importance of Monitoring Monitoring hemoglobin and hematocrit levels is important during testosterone therapy. Hemoglobin is responsible for carrying oxygen. Hematocrit shows the percentage of blood cell volume. A problem can occur if hematocrit levels go over 52 percent. Adjusting Therapy Adjusting how much testosterone you take or how you take it could help control your hematocrit levels. But, these changes might not always be enough. Therapeutic Phlebotomy: A Solution Therapeutic phlebotomy, which is also called bloodletting, is a medical procedure. It involves removing blood in a controlled way. The goal is to lower the levels of red blood cells in the body. Therapeutic phlebotomy is similar to blood donation. It can reduce hematocrit levels by about 3 percent for every pint of blood taken. It is essential to find a balance between how often blood is drawn and how much is taken out. This helps avoid loss of iron and ferritin, which can cause fatigue. After the procedure, you should: Stay for at least 15 minutes. Eat and drink something. Drink more fluids than usual for the next 4 hours. If there is bleeding from the blood draw site, raise your arm and apply pressure to the area. Before having the procedure, you should: Drink a lot of fluids to make up for the fluid that will be taken out. Have a good snack one hour before you arrive, like a muffin or a sandwich. Recommended Reading: High Hematocrit Caused by TRT: How to Lower It? Medical Conditions Requiring Therapeutic Phlebotomy Therapeutic phlebotomy is a medical procedure. It removes blood from the body. Doctors use this procedure to help treat different blood conditions. It can lower the chance of problems linked to too many blood cells, iron overload, or other blood issues. Here are some medical conditions that might need therapeutic phlebotomy: Hereditary Hemochromatosis (HH): This is a genetic disorder. It makes the body take in too much iron from food. This can cause iron overload. Therapeutic phlebotomy is used to remove the extra iron. This helps prevent organ damage and keeps you healthy. Polycythemia Vera (PV): This blood disorder means the body makes too many red blood cells, white blood cells, and platelets. Using therapeutic phlebotomy lowers the number of blood cells. This reduces the risk of blood clots and other problems. Secondary Polycythemia: This condition happens when the body has too many red blood cells due to low oxygen levels or other health issues. Therapeutic phlebotomy helps manage it by lowering the risk of blood clots and related problems. Porphyria Cutanea Tarda (PCT): This is a rare genetic disorder that affects heme production. Heme is important for making red blood cells. Therapeutic phlebotomy removes extra iron from the body. This prevents skin damage and other symptoms. Testosterone Replacement Therapy (TRT): Some people on TRT see an increase in red blood cell production. This can lead to high hematocrit levels. Therapeutic phlebotomy helps control these levels. It lowers the risk of blood clots and other complications. Metabolic Disorders: Certain metabolic issues, like diabetes, can increase blood cell production. Therapeutic phlebotomy helps manage these issues. It reduces the risk of blood clots and other problems. Infectious Diseases: Sometimes, therapeutic phlebotomy helps treat infectious diseases, like malaria or babesiosis. It works by removing infected red blood cells from the body. It is very important to remember that therapeutic phlebotomy must be done by a doctor in a medical place. If you have a medical condition that needs therapeutic phlebotomy, talk to your healthcare provider. They can help you find the best treatment for your situation. Guidelines for Monitoring and Donations You should have regular blood count tests after donating blood. This includes checking your hematocrit and ferritin levels. It’s usually okay to have a phlebotomy session every 2-3 months. This helps you avoid losing too much iron and ferritin. Be careful to keep an eye on your levels. If you give blood often because of high hematocrit, you can buy a blood donation panel. This panel has lab tests to tell you if you’re ready for your next blood donation. The tests include hematocrit, iron, total iron binding capacity (TIBC), and ferritin. This panel checks if: Your blood donation or therapeutic phlebotomy worked to lower your high hematocrit without hurting your ferritin or iron levels. It is safe to do another blood donation or therapeutic phlebotomy based on your ferritin or iron levels. Cautionary Measures for Maintaining Health   Risks of Excessive Donation Excessive blood donation can lower iron and ferritin levels. This may cause you to feel tired. It is generally recommended to start donating blood when your hematocrit levels are about 51–52 percent. Complementary Health Practices Baby aspirin and omega-3 fatty acids can help thin your blood and lower heart risks. However, they should not take the place of phlebotomy in treating polycythemia. Where to Get a Therapeutic Phlebotomy in the United States? Important note: Most blood donation centers need an order from a doctor if your hematocrit level is too high for a regular blood donation. The Red Cross has a list of rules to decide who can donate blood. National Organization American Red Cross: Website America's Blood Centers: Website Blood Centers of America: Website Blood Emergency Readiness Corps: Article Alaska Blood Bank of Alaska: Website Arkansas Arkansas Blood Institute: Website California Central California Blood Center: Website LifeStream Blood Bank: Website Northern California Community Blood Bank: Website San Diego Blood Bank: Website Stanford Blood Center: Website UCLA Blood & Platelet Center: Website Delaware Blood Bank of Delmarva: Website Florida OneBlood: Website SunCoast Blood Centers: Website Winter Haven Hospital Community Blood Center: Website Georgia Atlanta Blood Services: Website Shepeard Blood: Website Hawaii Blood Bank of Hawaii: Website Illinois Versiti Blood Center of Illinois: Website Rock River Valley Blood Center: Website South Bend Medical Foundation: Website Indiana Versiti Blood Center of Indiana: Website Iowa LifeServe Blood Center: Website Kentucky Kentucky Blood Center: Website Western Kentucky Regional Blood Center: Website Louisiana LifeShare: Website The Blood Center: Website Michigan Versiti Blood Center of Michigan: Website Mississippi Mississippi Blood Services: Website Missouri Community Blood Center of Greater Kansas City: Website Nebraska Nebraska Community Blood Bank: Website New York New York Blood Center: Website Ohio Hoxworth Blood Center: Website Versiti Blood Center of Ohio: Website Oklahoma Oklahoma Blood Institute: Website Pennsylvania Central Pennsylvania Blood Bank: Website Miller-Keystone Blood Center: Website Rhode Island Rhode Island Blood Center: Website South Carolina The Blood Connection: Website Tennessee Blood Assurance: Website Marsh Regional Blood Center: Website Texas Carter BloodCare: Website We Are Blood: Website South Texas Blood: Website Texas Blood Institute: Website Utah ARUP Blood Services: Website Virginia Inova Blood Donor Services: Website Washington Bloodworks Northwest: Website Wisconsin Versiti Blood Center of Wisconsin: Website Multiple States or Regions ImpactLife: Website (They serve Illinois, Iowa, Missouri, and Wisconsin) LifeSouth Community Blood Centers: Website (They serve several states) Alliance for Community Transfusion Services: Website Lifeline Blood Services: Website MEDIC Regional Blood Center: Website   Bloodworks Northwest Program for Therapeutic Phlebotomy Patients Bloodworks Northwest has a strong therapeutic phlebotomy program. It helps patients with certain medical issues, especially those with hereditary hemochromatosis. This program focuses on safely removing extra blood to control iron overload and keep good health. To use this service, patients need a valid order from their healthcare provider. The Bloodworks medical director will carefully review it to make sure it meets the medical rules. In addition to hereditary hemochromatosis, some patients may need therapeutic phlebotomy for different reasons. However, the main focus of the services is managing iron overload. Patients can make appointments at several Bloodworks centers, making it easy for them to access care in the area. Bloodworks Northwest wants to improve patient experience and health results by making the process simpler and offering clear instructions. Donor Centers Providing Therapeutic Phlebotomy Treatment When searching for donor centers that offer therapeutic phlebotomy treatment, it is important to find ones that are qualified and allowed to do this procedure. Many blood donation centers in the United States provide therapeutic phlebotomy for patients who have high hematocrit levels or similar health issues. These centers also follow donor eligibility criteria. Usually, a physician's order is needed to confirm that the treatment is right and required for the patient's health. These centers focus not only on medical care from healthcare experts but also on teaching patients about the phlebotomy process. If you need treatment, you should ask about the exact rules and needs at the center you choose. By picking the right donor center, you can get therapeutic phlebotomy in a safe and supportive place. This helps you manage your high hematocrit levels well. Service Availability and Requirements Therapeutic phlebotomy services are easy to find, but the requirements can differ based on where you go. Patients usually must get a doctor's order before making an appointment for therapeutic phlebotomy. This service is only available by appointment from Monday to Friday. The doctor’s order shows that this procedure is needed for the patient’s health. Centers may have different hours and ways to schedule appointments. Patients should call the facility they choose ahead of time. This will help them know what to expect when they visit. It’s also important to find out about any necessary preparations or documents needed for the procedure. By meeting these requirements, patients can have a smooth and timely phlebotomy experience. What Do I Need To Bring? When getting ready for a therapeutic phlebotomy appointment, patients need to bring a valid photo ID and any filled-out forms needed by the donation center. The doctor will send the required order to the place before the appointment. Still, it is a good idea for patients to check that all needed documents, including a receipt, are ready. Patients should know the guidelines given by the phlebotomy center. These can help make their veins easier to find. For example, there may be diet tips to follow before the procedure. Being prepared will help the appointment go well. This way, patients can get their treatment on time and avoid any delays. How Often Can I Give? The number of therapeutic phlebotomy sessions depends on each person's health needs and what their healthcare provider recommends. Usually, the doctor decides how often a patient should have blood withdrawals. They make this choice based on the person's hemoglobin levels and treatment goals. Patients may have appointments set every month, every three months, or depending on how they feel. Changes can be made if needed. It is very important for people to follow their doctor's advice. This helps them stay healthy and manage their hematocrit levels well. Conclusion In summary, it is important to understand and manage high hematocrit levels, especially for people receiving testosterone therapy. Checking levels regularly, having therapeutic phlebotomy when needed, and carefully managing treatment can lower risks and make the process safer. Always talk to a healthcare provider for advice that fits your needs. Further Reading How to Lower High Hematocrit - Effective Strategies Sleep Apnea: Effect on Testosterone and High Hematocrit Managing High Hematocrit Levels Induced by Testosterone Replacement Therapy High Hematocrit Caused by TRT: How to Decrease it

TRT Blood Work Tests For Monitoring Men on Testosterone Therapy Before undergoing testosterone replacement therapy (TRT), it’s vital to obtain a number of blood tests, which require a blood sample. The main blood tests to measure are total and free testosterone, hematocrit, PSA, estradiol, HDL cholesterol and others. Pre-treatment testing provides doctors with baseline values to diagnose hypogonadism (low testosterone) and assess overall health. Baseline tests are also conducted during TRT as well, ensuring that doctors can adjust TRT dose and catch side effects before they become an issue. Hematocrit Test PSA Test Estradiol Test Blood Pressure Estimated Glomerular Filtration Rate eGFR Liver Enzymes Test TSH Test Free T3 Test Total Testosterone Test Free Testosterone Test Ferritin Test HDL Cholesterol Test Click here for the Pre- TRT panel and the TRT panel (after 6-8 weeks on TRT) But do you know why these tests are needed or what they mean? Below, you’ll find some of the main blood tests that have been shown to be affected by TRT, so doctors measure them before and during therapy to prevent or manage side effects: Understanding Testosterone Blood Tests A testosterone blood test is a crucial diagnostic tool used to measure the level of testosterone in your blood. Testosterone, produced by the adrenal glands and gonads (testes in men and ovaries in women), plays a vital role in the development and maintenance of male reproductive tissues, bone density, and muscle mass. This test is commonly employed to diagnose and monitor conditions related to abnormal testosterone levels, such as hypogonadism (low testosterone) and hyperandrogenism (high androgen levels). There are several types of testosterone blood tests, each serving a unique purpose. The total testosterone blood test measures the overall amount of testosterone in your blood, including both bound and free testosterone. The free testosterone test measures the testosterone that is not bound to proteins in the blood, making it readily available to the body’s tissues. Additionally, the bioavailable testosterone test measures the testosterone that is available to the body’s tissues and is not bound to sex hormone-binding globulin (SHBG). Understanding these different tests helps in accurately diagnosing and managing conditions related to testosterone levels. Why Monitor Testosterone Levels on TRT? Testosterone replacement therapy (TRT) is a medical treatment designed to increase testosterone levels in individuals with hypogonadism. Monitoring testosterone levels on TRT is essential to ensure the treatment’s effectiveness and safety. Here are some key reasons why monitoring testosterone levels on TRT is crucial: Ensuring Normal Testosterone Levels: The primary goal of TRT is to elevate testosterone levels to within the normal range. Regular monitoring helps ensure that the treatment is effective and that testosterone levels are neither too high nor too low. Adjusting Dosage: Monitoring testosterone levels allows healthcare providers to adjust the TRT dosage as needed, ensuring optimal treatment outcomes. Identifying Side Effects: TRT can cause side effects such as acne, hair loss, and mood changes. Regular monitoring helps healthcare providers identify these side effects early and adjust the treatment plan accordingly. Monitoring Long-term Effects: TRT can have long-term effects on the body, including changes in bone density and cardiovascular health. Regular monitoring helps healthcare providers track these changes and make necessary adjustments to the treatment plan. By keeping a close eye on testosterone levels, healthcare providers can ensure that TRT is both effective and safe for the patient. Hematocrit Test Hematocrit refers to the proportion or percentage of red blood cells present in your total blood volume. Your red blood cells are responsible for transporting oxygen and nutrients throughout your body. Without enough red blood cells (a condition known as anemia), your body suffers from oxygen and nutrient deprivation. On the flip side, too many red blood cells cause high hematocrit that can turn your blood into a thick slurry that can seriously affect your circulation. A normal hematocrit for an adult male is anywhere from 42 to 54%. If your hematocrit results are lower than 41%, it means you have low proportion of red blood cells. Over 55%, and you have too many. One of the primary side effects of TRT is the production of too many red blood cells, leading to high hematocrit. High hematocrit can be lowered by blood donation or therapeutic phlebotomies (ordered by your doctor if you are not allowed to donate blood at a blood bank due to exclusion criteria). Just be careful: Do not donate blood more frequently than every 2 months since this can deplete your iron stores and make you tired. This test is included in CBC (chemistries and blood count) panel.   PSA Test Prostate-specific antigen, or PSA, is a protein that is produced in your prostate gland. It's designed to liquefy semen, which is necessary for the free swimming of sperm in ejaculate. It may also help to dissolve the cervical mucus to allow the sperm to enter the uterus for the purposes of impregnation. Normal PSA levels for men under 40 range between 0 and 2 ng/mL, while PSA levels for men older may raise slowly. A PSA test helps to detect extra-high levels of this protein. High PSA levels are the result of disruptions of the cellular structure of the prostate gland, which can be caused by a number of diseases--including cancer or an infection. Benign prostate hyperplasia, urinary retention, and prostatitis can be the cause of high PSA, but your doctor will want to monitor your PSA levels just to be sure the problem isn't a serious one. If PSA levels are high, your doctor may recommend a prostate exam or even a biopsy to determine the cause of your elevated PSA levels. TRT is contraindicated for men with PSA greater or equal than 4. Estradiol Test Estradiol is the primary female sex hormone, but did you know that the male body produces it from testosterone? It is produced in fat and liver cells from testosterone via the aromatase enzyme. Due to several factors like fat content, liver disease, medication effects and genetics, some men may produce more estradiol from testosterone than other men. New information has shown that men require a special estradiol test called sensitive estradiol test. The regular test used for women may overestimate estradiol in men due to interference of inflammatory markers like C-Reactive Protein (CRP). For the average man, estradiol levels should remain lower than 50 pg/mL, although there is little evidence of what the top of the estradiol test is in men who do not have low testosterone. If estradiol levels are higher than 50 and you start showing symptoms of high estradiol (gland growth under nipples, too much water retention), it may be necessary to take an estrogen blocker (aromatase inhibitor) . However, taking aromatase inhibitor like anastrozole should be done with careful monitoring of sensitive estradiol blood test since overdosing can cause health issues in men. A few of the reported effects of low estradiol levels include: joint pain, eye fatigue, loss of erections, limited sensitivity in the penis, sleepiness, and excessive urination. Long term low estradiol can decrease bone density. A few of the reported effects of high estradiol levels (in the presence of low testosterone) include: soft erections, water retention, excessive sweating, insomnia, bloating, hot flushes, brain fog, and high blood pressure. Blood Pressure The term "blood pressure" refers to the pressure in your arteries during the beating of your heart. There are two numbers: 1) The top number, or systolic, tells you the pressure in your arteries when the muscles of your heart contract. 2) The bottom number, or diastolic, tells you the pressure in your arteries when your heart relaxes and refills with blood in the pause between heartbeats. Healthy blood pressure is lower than 120/80. If your blood pressure rises anywhere from 121/81 to 139/89, you are pre-hypertensive. Crack 140/90, and you suffer from hypertension. Anyone over 180/100 is in serious hypertensive crisis. TRT can increase water retention, sodium uptake and hematocrit is some men, factors that can increase blood pressure. If your blood pressure rises too much, it can place excess strain on your blood vessels and potentially cause a crack. Should the blood vessels crack, the resulting clotting (your body's attempt to stop internal bleeding) can interfere with healthy blood flow--potentially leading to heart attacks, strokes, peripheral arterial disease, and other cardiovascular problems. Estimated Glomerular Filtration Rate eGFR Your glomerular filtration rate (GFR) is an indication of your kidney function. The higher your GFR, the more blood passes through the glomeruli (the filters in your kidneys that remove waste from your blood) every minute. A healthy GFR is anywhere from 90 to 120 mL/min/1.73 m2. Senior citizens will often have lower GFR levels, due to the fact that kidney function decreases with age. Note: It's important to understand that each lab has its own measurements, so what is "healthy" to some may be low with others. If your GFR drops below 60 and remains at that low level for more than 3 months, it's an indication of chronic kidney disease. Liver Enzymes Test Your liver is responsible for a number of important functions, such as breaking down nutrients, producing the proteins that clot your blood, and eliminating toxins. The enzymes produced by your liver are responsible for carrying out these functions. However, if the liver suffers damage, those enzymes tend to leak into your bloodstream. High levels of liver enzymes are a good indicator that your liver has been damaged ALT and AST are the two most common liver enzymes. AST should be anywhere from 10 to 40 units per liter of blood, and ALT should be from 7 to 56 units in every liter of blood. Be aware that exercise may increase these two enzymes in a non-clinically significant way. Only oral testosterone replacement has been shown to increase liver enzymes. TSH Test Thyroid-stimulating hormone, or TSH, is a hormone produced by your pituitary glands in order to stimulate your thyroid gland to produce T3 and T4 hormones. These thyroid hormones play a role in your body's metabolic function. Normal TSH levels should be between 0.5 and 3.5 U/ml (different guidelines show different upper TSH levels). Many educated doctors test for free T3 and free T4 (the unbound thyroid hormones) when TSH is over 3 since they believe this will provide a better picture of thyroid health. If TSH levels are low, it's an indication of hyperthyroidism. If TSH levels are very high, it's an indication of hypothyroidism. Free T3 Test Free T3 refers to unbound T3 (thyroid) hormone in your bloodstream. T3 is the more important of the thyroid hormones, but it can only be produced from T4. This means your body needs to produce T4 then turn it into T3. Once the T3 is unbound from the protein molecules, it can then be used by your body to stimulate metabolic function in all your cells. Normal Free T3 levels are anywhere from 230 to 620 pg/d. If free T3 is low, your doctor may test for thyroid antibodies to ensure that you do not have an autoimmune disease called Hashimoto's. Total Testosterone Test Total testosterone test measures refer to all of the testosterone circulating in your body. Some testosterone circulates freely, while some is bound to protein molecules. The whole point of TRT is to increase your testosterone levels. A normal testosterone range is anywhere from 350 to 1070 ng/dL. Low testosterone can cause low mood, sex drive, fatigue and other symptoms. In some men, too much testosterone in the body can lead to excessive estradiol, acne, oily skin, hair loss, testicular shrinking, and increased blood viscosity due to high red blood cells. Free Testosterone Test Free testosterone refers to the testosterone circulating in your body that is NOT bound to protein molecules like albumin and sex hormone binding globulin. It is believed that your body is more easily able to use free testosterone. It usually runs at about 2 percent or higher of total testosterone. Testosterone Test Results and Interpretation Testosterone test results are typically reported in nanograms per deciliter (ng/dL). The normal range for testosterone levels varies depending on age, sex, and the laboratory performing the test. Here are some general guidelines for interpreting testosterone test results: Normal Testosterone Levels in Adult Men: 300-1,000 ng/dL Normal Testosterone Levels in Adult Women: 15-70 ng/dL Low Testosterone Levels: Less than 300 ng/dL in men or less than 15 ng/dL in women High Testosterone Levels: Greater than 1,000 ng/dL in men or greater than 70 ng/dL in women It’s important to note that testosterone levels can fluctuate throughout the day and may be influenced by various factors such as sleep, stress, and exercise. Therefore, a single testosterone test result may not provide a complete picture of an individual’s overall testosterone levels. Healthcare providers may recommend repeat testing to confirm the results and monitor changes in testosterone levels over time. Understanding your testosterone test results and their implications can help you and your healthcare provider make informed decisions about your treatment plan. Ferritin Test Ferritin is a protein that is responsible for storing iron and releasing it when your body needs to produce red blood cells. If you suffer from an iron deficiency, your ferritin level are likely to be low. Ferritin levels also fall when you give blood (a common method of lowering hematocrit). Normal ferritin levels for men is anywhere from 30 to 300 ng/mL. However, if ferritin levels are too low (after a blood donation), your body is unable to store iron, meaning it will not be able to produce new red blood cells. If you are considering donating blood to lower your hematocrit, it's a good idea to check your ferritin levels first. Your body needs enough of this protein to reproduce the red blood cells you are donating HDL Cholesterol Test High density lipoprotein, also known as HDL cholesterol, is the "good" type of cholesterol. It's responsible for counteracting the effects of low-density lipoprotein, or LDL cholesterol. Low HDL and high LDL may lead to a wide range of cardiovascular problems, including blocked arteries, stroke, heart attack, and peripheral arterial disease. According to experts, even a 5 mg/dL decrease in HDL cholesterol can increase your risk of coronary heart disease by as much as 25% Normal HDL cholesterol levels are anything above 40 mg/dL. Unfortunately, decreased HDL is a known side effect of TRT in some men using higher testosterone doses. Your doctor will monitor HDL cholesterol via a lipid panel in order to ensure that you are not at risk for heart disease. Educate yourself about testosterone replacement side effects 

High hematocrit levels, which measure the percentage of red blood cells in the blood, can be signs of several underlying health conditions and they are also a common side effect of testosterone replacement therapy (TRT). High hematocrit levels can increase the risk of developing blood clots, strokes, and other serious complications, especially for those with an underlying condition. Low red blood cell levels, also known as low hematocrit levels, can indicate conditions such as anemia, while high red blood cell levels often signal dehydration and could indicate other conditions, such as polycythemia, increasing a person’s chance of developing blood clots or experiencing blood loss. We will review the different ways to lower the hematocrit and the number of red blood cells on TRT. How to Lower the High Hematocrit Caused by Testosterone Replacement Therapy (TRT) Testosterone replacement therapy (TRT) is one of the most effective ways to combat low testosterone levels, but it's vital that you understand the risks associated with the treatment. As with any form of hormone replacement therapy, there are a few downsides to receiving regular injections of testosterone. One of the main TRT side effects is increased hematocrit, also known as erythrocytosis, which can be a sign of androgen deficiency. This article will explain why this happens, the potential long-term health consequences, and how to prevent or manage this issue. Since abnormally high hematocrit values can pose serious health problems, this article will analyze the correlation between testosterone therapy and high hematocrit. TRT, sleep apnea, smoking, and red blood cell production are contributing factors that can cause high hematocrit that can increase cardiovascular risks if not properly managed. This article explains the basics of how to manage high hematocrit while using testosterone therapy. What is hematocrit? There are several standard ways to measure red blood cells: hematocrit, hemoglobin, and RBC (red blood cell count). All of these are related, and doctors will usually look at two or more. Hematocrit, also referred to as the proportion of red blood cells, is a measurement of how much of a person's blood is made up of red blood cells, also known as whole blood. Hemoglobin, on the other hand, is a density or concentration measurement and is expressed in grams per liter or deciliter. (Hemoglobin is, if you will recall from your high school biology, the iron-based protein that transports oxygen.) RBC is a simple count and is usually expressed as the number of million red blood cells that you have per microliter. Usually, hematocrit is three times the amount of hemoglobin and can be measured through a simple blood sample test. What are the normal ranges for hematocrit?  Normal levels of hematocrit for men range from 41% to 50%. normal level for women is 36% to 48%. Why does TRT increase hematocrit? Erythrocytosis is a medical condition that appears when the body makes too many red blood cells. RBCs are responsible for transporting oxygen to organs and tissues. When there are too many, the blood can become too thick and cause cardiovascular complications. There are two types of erythrocytosis: primary and secondary. Problems with the bone marrow, such as bone marrow disease, are typically the cause of primary erythrocytosis. RBCs are made in the bone marrow, and something might trigger an increase in their production. Certain diseases or medications, such as testosterone replacement therapy, can cause secondary erythrocytosis. Some studies concluded that testosterone reduces hepcidin (a hepatic hormone), which is related to iron absorption pathways. When hepcidin is reduced, erythrocytosis is increased [1] An increase in hemoglobin (Hb) and hematocrit (Hct) is indicative of this medical condition. When the Hb is higher than 18.5 g/dL and the Hct is higher than 52% in men, the patient suffers from erythrocytosis.   What are the risks of high hematocrit? One of the primary risks of testosterone that you need to be aware of is called polycythemia or erythrocytosis. This is a condition where your body produces too many red blood cells, also known as high hematocrit levels or secondary polycythemia. Hematocrit refers to the percent of red blood cell content in your blood, also known as Hct levels. If your hemocrit levels rise, your blood will become too thick or viscous. This can, in turn, make it more likely that you will develop strokes, heart attacks, and clotting events. Polycythemia is serious and potentially life-threatening if untreated. Since the RBC count is too high in people with erythrocytosis, the blood viscosity also increases, which can lead to various potentially life-threatening medical issues such as venous thromboembolism. This essentially means that tiny blood clots separate from their original source and travel through veins and capillaries, causing blockages that result in stroke, myocardial infarction, or other complications related to reduced blood flow and blood volume. Individuals with high hematocrit levels may also be at risk for conditions such as polycythemia vera, a bone marrow disease that causes an abnormal increase in red blood cells and can lead to symptoms of polycythemia vera such as headache, dizziness, and fatigue. Other potential risks include congenital heart disease, exposure to high altitudes, and reactions to blood transfusions. It can be quite stressful for a man who has finally gotten on TRT, feels better, and then finds out that his hemoglobin is high. Of course, he can always lower his testosterone dosage to try to solve the problem, but this may not be a solution that either doctor or patient wants to pursue. Many men have found that their erectile dysfunction is greatly helped and/or morning erections and libido have returned. The last thing they want to do is lower their dose. So why even worry about a high hemoglobin or RBC count? What’s a few extra red blood cells anyway? Unfortunately, high hemoglobin (or RBCs) is a risk factor for ischemic stroke, i.e., the standard kind of stroke where there is a loss of blood supply to tissues such that permanent damage is usually incurred. [2] Of course, a stroke can be a life-changing (or life-ending) event and should be avoided at all costs. There is also a longer-term risk: elevated hemoglobin could lead to unhealthy iron store levels, which are associated with heart disease and dementia. Iron in tissues can lead to oxidative damage. Just look at what some recent studies have concluded: “Low and high hemoglobin concentrations in older persons are associated with a lower level of cognitive function in old age, particularly in semantic memory and perceptual speed.” [3] “In older persons without dementia, both lower and higher hemoglobin levels are associated with an increased hazard for developing AD [Alzheimer’s Disease] and more rapid cognitive decline.” [4] Can hematocrit stabilize in men on TRT? Hematocrit may stabilize after long-term testosterone replacement. Although there is only one study done in mice, it may explain why hematocrit may eventually decrease and stabilize in men on TRT. There seems to be an adaptive mechanism that makes red blood cell indices change while hematocrit stabilizes. In some men, red blood cell indices (MCV and MCHC) start changing after starting TRT as a way for the body to compensate for the extra production of red blood cells. There are three red blood cell indices: mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC). They are measured by a machine, and their values come from other measurements on a CBC panel. The MCV shows the size of the red blood cells. The MCH value is the amount of hemoglobin in an average red blood cell. The MCHC measures the concentration of hemoglobin in an average red blood cell. [5] Another study that followed frequent blood donors found a reduction in ferritin in them, created as a way for the body to increase iron absorption in the presence of lower hematocrit. Ferritin and hematocrit stabilized after five donations.[6] How to Lower High Hematocrit on TRT Some physicians and TRT guidelines believe that the best way to lower hematocrit is to stop TRT. But stopping TRT can have negative consequences in the quality of life, as men who do so tend to stay hypogonadal for months, and most do not return to “normal levels.”. Fortunately, there are several ways to decrease high hematocrit and also potentially prevent it from happening. Give Blood. This is a time-proven technique for men on testosterone therapy to lower their hemoglobin levels. And you are helping out someone else while you’re doing it! Every unit of blood donated can decrease hematocrit by 3 points, which is equivalent to one pint of blood. However, be careful not to donate more frequently than every 2.5 months, as the Red Cross advises, to prevent losing too much iron and ferritin, which can cause fatigue in men using testosterone therapy. You can check your iron and ferritin levels with this iron blood test. It's recommended that you donate when you are in the 51–52 hematocrit range. However, some organizations (like the Red Cross) will reject blood with a hematocrit higher than 53%, so it is good to avoid that high hematocrit level if you want to donate blood. Men who are rejected from blood donations because of high hematocrit can still give blood if their physicians call in an order for a therapeutic phlebotomy at the local blood center.   Lower Your TRT Dose. If you have high hemoglobin or hematocrit from testosterone therapy, then your doctor may require you to lower your dose. This is not always a bad thing, as some men are actually taking more testosterone than they actually need, which can lead to side effects in both the long and short term.   Drink Water. It is important to remember that hemoglobin is very dependent on your hydration levels. If you were dehydrated when you had your blood drawn, this could have made things worse. If you think you were dehydrated, discuss a retest with your doctor.   Treat Thyroid Issues. Hypothyroidism (low thyroid function) can lower your RBC counts, and hyperthyroidism (high thyroid function) can raise them, too. If you haven’t checked your thyroid function lately, this might be wise. And don’t forget to get a full thyroid panel, including thyroid antibodies, if you can afford it. [10]   Consider transdermal (topical) or oral testosterone. One research summary stated that topical testosterone creams or gels increase hematocrit, in general, less than intramuscular testosterone injections: “Intramuscular testosterone is the only form that significantly increases hematocrit above normal levels. However, it does so strongly, with up to a 6% change from baseline. The runner-up is testosterone gel, with an average increase of 2.5% over baseline levels.” [7]. Therefore, if you are on intramuscular injections and struggling with high hematocrit or hemoglobin, going on topicals may help a little. Discuss with your physician. NOTE: A cheap alternative is Compounded Testosterone Creams and Gels. Another emerging option is oral testosterone products.   Switch from intramuscular injections to lower-dose subcutaneous Subcutaneous Testosterone Injections. Two hundred thirty-two men took part in a University of California study. Baseline levels were recorded for all men in each of the four measurement areas and then again at 6–12 weeks post-treatment. The results showed that men who underwent subcutaneous testosterone (SubQ) injections had a 14% greater increase in total testosterone levels compared to the testosterone levels of intramuscular testosterone injection (IM) patients. SubQ patients also had a 41% lower hematocrit post-therapy than IM patients and 26.5% lower estradiol levels. For both groups of men, there were no elevated levels of PSA. [7]   Avoid or Reduce the Consumption of Red Meats. It is interesting because one of the criticisms that meat eaters level against vegetarians is that plant foods have many “anti-nutrients” that can slow down or bind with minerals such as iron. For example, organizations like Weston Price love to castigate vegetarians for their phytic acid consumption. Phytic acid is present in plant foods and binds to iron, magnesium, phosphorous, and calcium. It can, if overconsumed, lead to mineral deficiencies. However, Dr. Bernard points out that usually, it is likely very health-protective for most people because these minerals, as in the case of zinc and iron, are neurotoxic at even relatively low levels of tissue accumulation. Research has also shown that too much iron also contributes to heart disease, and there may be a link to colon cancer as well. [8]So, avoiding red meats, which are high in iron, stands a good chance of lowering your hemoglobin scores and protecting your long-term health unless some other preventative action is taken (such as giving blood). Actual dietary studies are required to support this statement. As a verification, one study of vegetarians and non-vegetarians found that females had significantly lower hemoglobin levels. Males had lower levels, but it may not have been statistically significant. [8] However, another study was more definitive and concluded: “It was found that hemoglobin, hematocrit, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, white blood cells, neutrophils, serum ferritin, and serum vitamin B12 in vegetarians were significantly lower than control subjects.” [11] Ferritin is a key measure, by the way, because it indicates that tissue levels of iron are lower and thus will likely cause less permanent damage. (This study did show that some vegetarians were iron deficient, as should be noted.)   Fix Sleep Apnea. Sleep apnea can cause depleted oxygen saturation values that can enhance the body's ability to produce more red blood cells and hemoglobin as a way to compensate for the low blood levels of oxygen during the sleep cycle. And, sure enough, there are studies that confirm this as well. [12] So, if your hematocrit, hemoglobin, or RBCs are running high, think about getting tested for sleep apnea. A recent study commented that “one possible explanation is that repeated episodes of nocturnal hypoxia (low oxygen condition) lead to a hypercoagulable state that predisposes patients to thrombotic (blood clotting) events. There is evidence supporting a wide array of hematological changes that affect hemostasis (e.g., increased hematocrit, blood viscosity, platelet activation, clotting factors, and decreased fibrinolytic activity).”   Reduce Inflammation. Hepcidin, the iron absorption-modulating hormone, can be decreased even further by inflammation. Checking for infections, CRP levels, etc., and then treating the underlying cause may help. [13]   Consider Curcumin (Turmeric). Turmeric or curcumin, is increasingly studied as an anti-inflammatory and anti-cancer agent. It binds to ferric iron in the gut and causes iron deficiency in mice. A case history reported a possible case of iron deficiency anemia in a human taking turmeric. [14]    Stop Smoking. Smoking reduces the amount of oxygen in the blood and makes the body produce more red blood cells and hemoglobin to compensate for that lower oxygen saturation.[14]    Treat High Blood Pressure with Losartan. If you have high blood pressure, consider taking Losartan.[15] Losartan can be safely and effectively used to normalize hematocrit in patients with COPD and erythrocytosis, an effect that could obviate the need for therapeutic phlebotomy.    Consider Grapefruit. Grapefruit extract (narigin) may decrease hematocrit [16]. There was no significant difference between ingesting 1/2 or 1 grapefruit per day, but a decrease in hematocrit due to ingestion of grapefruit was statistically significant at the p less than 0.01 level. However, discuss with your physician the fact that grapefruit can increase the blood levels of medications. The most important message of this article is that monitoring hematocrit every few months is a smart way to minimize cardiovascular risks associated with high hematocrit. You can buy your hematocrit and related tests on DiscountedLabs.com at affordable prices. Hematocrit is included in the CBC and other panels on Discounted Labs: Get Your Hematocrit Test Now Testosterone, Hematocrit, Ultrasensitive Estradiol and Prolactin Panel Hematocrit + Total and Free Testosterone References The Journal of Clinical Endocrinology & Metabolism, Volume 95, Issue 10, 1 October 2010, Pages 4743–4747 Eur Neurol, 1996, 36(2):85-8. Neuroepidemiology, 2008 December, 32(1): 40 46, “ Relation of Hemoglobin to Level of Cognitive Function in Older Persons” Neurology, 2011 Jul 19, 77(3):219-26, “Hemoglobin level in older persons and incident Alzheimer disease: prospective cohort analysis. Endocrinology. 2015 May; 156(5): 1623–1629. TRANSFUSION 2008; 48: 2197-2204. Comparison of Outcomes for Hypogonadal Men Treated with Intramuscular Testosterone Cypionate versus Subcutaneous Testosterone Enanthate SIU Academy. Choi E. 10/10/20; 309864; BSP-06.01  International Journal of Natural and Applied Sciences Vol. 2 (3) 2006: pp. 174–177, “Comparative study of the hemoglobin concentration of vegetarian and non-vegetarian subjects in Ogun state, Nigeria” World J Gastroenterol, 2006 September 21, 12(35): 5644-5650, “Hemoglobin induces colon cancer cell proliferation by release of reactive oxygen species” Iran J Ped Hematol Oncol, 2013; 3(2):73-77, “Effect of Thyroid Dysfunctions on Blood Cell Count and Red Blood Cell Indices” J Med Assoc Thai, 1999 Mar, 82(3):304-11, “Hematological parameters, ferritin and vitamin B12 in vegetarians” Can Respir J. 2011 Nov-Dec; 18(6): 338-348, “Coagulability in obstructive sleep apnea” Am J Kidney Dis. 2012;59(3):444-451

Can Testosterone Make You Tired?  Some men start testosterone replacement therapy (TRT) to address low T and testosterone deficiency and find out their baseline fatigue and low energy get worse. Testosterone and Energy Levels Testosterone controls energy levels in men. When testosterone is within normal range, men feel more energetic and motivated. Testosterone supplementation can also help restore energy in men with low testosterone. Low testosterone can cause fatigue, lethargy, and feeling unwell. Testosterone helps regulate the body’s metabolism, which converts food into energy. Studies have shown that testosterone levels are related to energy levels. Men with low testosterone have lower energy levels; men with normal or high testosterone have higher energy levels. Testosterone replacement therapy also helps improve energy in men with low testosterone. By getting testosterone levels back to normal range, many men feel a big boost in overall energy and vitality. Why does TRT cause fatigue? TRT can cause fatigue in some men for the following reasons: Overstimulation of the body: Increased testosterone can overwork the body and cause fatigue and exhaustion. Insomnia: Some men on testosterone therapy may have difficulty sleeping and get fatigue. Hormonal imbalance: Sudden increase in testosterone can cause imbalance with other hormones in the body and cause fatigue and other symptoms. Side effects of the medication: Testosterone medication can cause side effects like acne, fluid retention, and mood changes, which can also cause fatigue. Testosterone injections, which are a common method of TRT, can cause these side effects. As testosterone levels drop, men may feel more fatigue and lower energy levels, which can be worsened by TRT. Note that testosterone therapy can also help improve energy and reduce fatigue in some men but it’s best to discuss the benefits and risks with a healthcare provider before starting treatment. If no improvement in fatigue is seen after 6 weeks of testosterone replacement, other factors beyond hypogonadism may be present. This article will review a few ways to find out what causes TRT fatigue. Low Testosterone Symptoms Low testosterone can cause many testosterone deficiency symptoms, including: Fatigue and lethargy Low sex drive Erectile dysfunction Loss of muscle mass and strength Increased body fat Decreased bone density Mood changes like depression and anxiety Difficulty concentrating and memory problems If you have any of these symptoms, consult a healthcare professional to find out if low testosterone is the cause. A proper diagnosis will help you explore treatment options, including testosterone replacement therapy, to alleviate these symptoms and improve your life. Thyroid Function and Hormonal Imbalance: The thyroid is a butterfly-shaped endocrine gland located in the lower front of the neck. It produces thyroxine or T4, which is converted to triiodothyronine or T3. T4 production is controlled by thyroid-stimulating hormone or TSH, which is produced by the pituitary. Hypothyroidism, or low thyroid hormone production, can cause sexual dysfunction and depression, fatigue, dry skin and hair, weight gain, and increased sensitivity to cold. Blood tests to measure TSH, T4, and T3 are available and widely used. The American Thyroid Association (thyroid.org) has great info on how to find out if you have hypothyroidism that’s causing your fatigue. Testosterone can decrease thyroxin-binding globulin and total T4 serum levels and increase resin uptake of T3 and T4. Free thyroid hormone levels remain the same and there’s no clinical evidence of thyroid dysfunction. Once thyroid hormone levels are normalized, testosterone tends to increase naturally. Check your thyroid hormones here: Choose Your Test | Discounted Labs   Adrenal Function and Chronic Fatigue: The adrenal glands are located in the abdomen above the kidneys and regulate stress in the human body. When the body is in an emergency situation, the adrenal glands release hormones like adrenaline to enable the body to respond. You may have experienced this reaction called the “fight or flight” response if you were in danger, fear, or shock. Adrenal fatigue is the controversial idea that the adrenal glands can get worn out and cause illness if continuously overstimulated. Proponents of the “adrenal fatigue” theory believe that the adrenal glands may be overworked in some individuals and therefore get “fatigued” and unable to produce enough hormones. When your adrenal glands are exhausted, your cortisol levels drop significantly. Cortisol is your natural stress hormone. Low sex drive and infertility are symptoms of adrenal fatigue. Other symptoms include chronic fatigue, low blood pressure and low blood sugar, dizziness, headaches, anxiety or panic attacks, depression, and other equally debilitating problems. Some doctors may prescribe low doses of corticosteroids if your morning cortisol levels (measured by blood, saliva, or urine tests) are low. But be careful with corticosteroids, as they can increase fat mass and decrease bone density if given in doses higher than what the healthy adrenals would produce. Check your adrenal health. DHEA and Testosterone Levels: The adrenal glands also produce dehydroepiandrosterone (DHEA), the most abundant hormone in the bloodstream. The body uses DHEA as the starting material to produce the sex hormones testosterone and estrogen in men. DHEA supplementation can increase DHEA levels, which in turn can support testosterone production. Studies show it only increases testosterone in women. DHEA production decreases in most people after age 40. In people 70 years old, DHEA levels will be 30% lower than what they were at age 25. Low DHEA levels are associated with many degenerative conditions. Some studies are controversial and inconclusive that people with immune deficiencies and fatigue may benefit from supplementation with this hormone. It’s still available over-the-counter in the US. This may change soon, as a new bill was passed by Congress classifying it as a performance-enhancing steroid (no studies show it has such an effect). One study showed that women with normal DHEA levels can convert it into testosterone as their body needs while men don’t benefit the same way. You need a blood test to know if you have low DHEA-S since most of the DHEA converts into this sulfated form. Common doses for women are 5-30 mg a day, while men benefit from 25-100 mg a day (to bring low DHEA-S to normal). NOTE: Do not use DHEA supplements unless your blood levels of DHEA-S are low. If low, start at a low dose and get your DHEA-S tested again after a month. Men who use DHEA supplements may have problems with higher estrogen levels since DHEA can also convert into estradiol. This can cause gynecomastia and water retention. If you start taking DHEA, get your blood levels checked to make sure they are not above normal. There are many claims about DHEA being an anti-aging and anti-cancer cure but none of these claims have been proven with strong data. To make diagnosis easier, we have created this new Fatigue Panel on DiscountedLabs.com at a discount. Click here: Comprehensive Fatigue Panel Sleep Apnea: Sleep apnea is a sleep disorder in which a person stops breathing or breathes shallowly many times during sleep and therefore doesn’t get enough restful sleep; oxygen levels in the blood drop and the brain starves of oxygen. Besides causing daytime fatigue, it can increase blood pressure and cardiovascular risks. Testosterone replacement therapy has been linked to the worsening of sleep apnea or the development of sleep apnea, especially in men who use higher doses of testosterone or who have other risk factors for sleep apnea (high body weight, thick necks, snoring, alcohol consumption, etc.). Upper-airway narrowing doesn’t seem to be caused by testosterone replacement therapy; it suggests that testosterone replacement contributes to sleep-disordered breathing by central mechanisms rather than by anatomical changes in the airway. Tell your doctor if your spouse or partner complains that you snore loudly at night and feel fatigued. The only way to know for sure if you have sleep apnea is to have your doctor refer you to a sleep lab for a sleep study. If you are diagnosed with sleep apnea, a continuous positive airway pressure (CPAP) machine can be prescribed to help open up your airways with a small air pump while you sleep. Some people love it; some hate wearing a mask while being hooked up to a machine at night. I have seen men regain their quality of life after starting CPAP. It’s covered by insurance, Medicare, and most HMOs. A new option for those who hate CPAP machines with mild to moderate apnea is the use of oral appliances. Worn in the mouth like an orthodontic appliance during sleep, oral appliances keep the soft tissue from collapsing and interrupting normal breathing patterns. The purpose of the oral appliance may be to reposition the lower jaw, tongue, soft palate, and hyoid bone into a certain position; to keep the airway open with stabilization of the tongue and jaw; or to provide artificial muscle tone to prevent collapse and resulting airway blockage. The doctors will fit your oral appliance for comfort by using a mold of your mouth to design your unique fit. Fatigue Management with Testosterone Therapy Testosterone therapy can help manage fatigue in men with low testosterone. Testosterone gel is another way to get testosterone therapy to help manage fatigue. Testosterone therapy can bring many health benefits, including improved cardiovascular health, better blood sugar control and reduced risk of osteoporosis and diabetes. But it’s important to understand the benefits and risks of testosterone therapy and to discuss them with your doctor. Some men will experience a big boost in energy and overall well-being; others will find their fatigue persists or even worsens. This variability is why personalized medical advice and regular monitoring are important to tailor the treatment to your needs. Energy Tips In addition to testosterone therapy, there are several lifestyle changes that can help men regain energy and overall health. These are: Regular Exercise: Strength training and cardio exercises can help build muscle and boost energy. Exercise also helps with better sleep and reduces stress, which can further increase energy. Healthy Diet: Eating a balanced diet rich in protein, healthy fats, and complex carbohydrates can give you energy all day. Lean meats, fish, nuts, seeds, and whole grains are good choices. Sleep: Aim for 7-9 hours of sleep per night to help regulate testosterone and energy. Good sleep hygiene practices like a consistent sleep schedule and a restful environment can make a big difference. Stress Management: Meditation, yoga, or deep breathing exercises can help manage stress, which can help increase energy. Chronic stress can lower testosterone so finding ways to cope is important. Hydration: Drinking plenty of water throughout the day is key to maintaining energy and overall health. Dehydration can cause fatigue and decreased physical performance. Natural Testosterone Boosters While testosterone replacement therapy may be needed for some men, there are also natural testosterone boosters that can increase testosterone. These are: Exercise Regularly: Exercise, especially weightlifting and high-intensity interval training, can increase testosterone. Eat a Healthy Diet: A diet rich in protein, healthy fats, and complex carbohydrates can support testosterone. Get Enough Sleep: Sleep is key to testosterone production so aim for 7-9 hours of sleep per night. Reduce Stress: High stress can lower testosterone so find ways to manage stress through meditation or yoga. Get Enough Vitamin D: D: Vitamin D is important for testosterone production, so make sure you get enough through sun exposure, supplements, or fortified foods. Implementing these lifestyle changes can support your body’s natural testosterone production, and if you’re already on testosterone replacement therapy,. Testosterone Therapy Risks and Considerations Testosterone therapy can be good for men with low testosterone, but there are testosterone side effects and considerations to be aware of: Blood Clots and Stroke: Testosterone therapy can increase the risk of blood clots, which can cause stroke or other cardiovascular events. Cholesterol and Cardiovascular Health: Testosterone therapy can affect cholesterol levels, which can increase heart disease risk. Lipid profiles should be monitored regularly. Fertility and Sperm Production: Testosterone therapy can reduce sperm production. Men who want to have children should talk to their doctor. What to Expect from Testosterone Men on testosterone therapy can expect: Increased Energy and Reduced Fatigue: Many men feel more energetic and less fatigued after starting testosterone therapy. More Muscle and Strength: Testosterone therapy can increase muscle mass and strength for better physical performance and overall health. Better Bone Density: Testosterone therapy can increase bone density, reducing the risk of osteoporosis and fractures. Libido and Sexual Function: Many men experience improved libido and sexual function, which can improve their quality of life. Overall Well-Being: Testosterone therapy can improve mood and overall sense of well-being for better quality of life. But you need to have realistic expectations and understand that testosterone therapy is not a magic pill. It may take several months to see the full effects and regular monitoring and adjustments may be needed to get the best results. Testosterone Monitoring Monitoring testosterone levels is crucial to ensure treatment is working and to minimize side effects. This means working with a healthcare professional to track progress and adjust therapy. Why Blood Tests Blood work is needed to monitor testosterone levels and adjust treatment. These tests can: Confirm Diagnosis: Blood tests can confirm low testosterone levels so testosterone therapy is appropriate. Monitor Results: Testing helps to monitor testosterone therapy and ensure testosterone levels are in range. Identify Side Effects: Blood tests can detect side effects like changes in cholesterol or liver function so treatment can be adjusted. Healthy Ranges: Keeping testosterone levels in a healthy range is key to minimizing risk and maximizing benefits. You need to work with a healthcare professional to determine the best testing schedule and to make sure testosterone levels are being monitored regularly. This proactive approach will get the best results and overall health. Get your own testosterone test here. When to See a Doctor for Fatigue If you have persistent or severe fatigue, you need to see a doctor. Fatigue can be a sign of an underlying medical condition like low testosterone, anemia, or diabetes. A healthcare professional can help figure out what’s causing your fatigue and develop a plan to treat it. If you have any of the following, see a doctor: Fatigue that lasts more than 2 weeks Severe fatigue that affects daily activities Fatigue with other symptoms like weight loss, fever, or night sweats Fatigue that doesn’t go away with rest or sleep A healthcare professional can do a physical exam, take a medical history and order diagnostic tests like blood work to figure out what’s causing your fatigue. Knowing the cause is key to developing a treatment plan and overall health and wellness. References Here are the clickable links with their corresponding titles: Can Testosterone Replacement Therapy Cause Insomnia? TRT and Fatigue: Understanding the Connection and How to Overcome It Testosterone Therapy: Effects and What to Expect Experiencing Extreme Tiredness and Fatigue on TRT? Can Testosterone Therapy Make Me Less Tired? Addressing Fatigue with Testosterone Pellets

Table of Contents Symptoms Of Hypogonadism (Low Testosterone) And How To Diagnose Primary and secondary hypogonadism (Low Testosterone) The pituitary gland and problems associated with it Exploring Hyperprolactinemia (High Prolactin) and Its Implications in Low Testosterone Throwing a spotlight on the pituitary and its function Pituitary imaging in the diagnosis of low testosterone Learning about thyroid and its role in low testosterone Conclusions Testosterone replacement therapy is available in many forms and can be beneficial for men who have low testosterone levels. When the body doesn't produce enough testosterone (a condition also known as hypogonadism), men can experience different symptoms such as low sex drive, fatigue, bad mood, and irritability. The body might not produce enough testosterone because of different factors. For example, the pituitary and thyroid glands play an important role in the production of testosterone and if they are not healthy, young men might experience low testosterone levels. It is important to note here that the production of testosterone decreases as men age and this is normal to be so. However, approximately 0.1% of men aged 40-49 years and about 3-5% of men aged 60-79 develop androgen deficiency which can negatively influence their lifestyle. Those who have type 2 diabetes and are obese are at a higher risk of having low blood testosterone. Before taking advantage of testosterone replacement therapy, it is important to assess the health of other organs in the body which are directly related to the production of testosterone such as the pituitary and thyroid. The pituitary gland is a very small organ situated at the base of the skull, weighing just 0.018 oz. It is responsible for releasing the growth hormone as well with the production of testosterone. If a patient is suspected of having low testosterone levels, doctors usually recommend analyzing and treating the pituitary gland as well, before opting for testosterone replacement (TRT) therapy. Similarly, the thyroid is an endocrine gland situated in the neck. It is responsible for the production of numerous hormones which help the body's metabolic processes. It also plays a vital role in the production of testosterone.   Symptoms Of Hypogonadism (Low Testosterone) And How To Diagnose   This type of medical condition can have various symptoms and as mentioned earlier, people who are obese or have type 2 diabetes are more likely to develop hypogonadism. Other risk factors include chronic depression, cancer, a medicine which interferes with testosterone production, chronic illness, and others. People who abuse opiates and glucocorticoids are also at a higher risk of developing hypogonadism over time. Proper testosterone production is strictly correlated with a healthy lifestyle, which involves working out regularly and eating a balanced diet. Smoking and cardiovascular diseases can also put someone at risk of developing low blood testosterone. By improving the testosterone level through replacement therapy or by treating any existing pituitary or thyroid issue, the overall quality of life can be drastically increased. For example, men who have tried testosterone replacement therapy report better sexual satisfaction, better mood, more energy and a general sense of wellbeing. In very rare cases, the testosterone level can be low because of other factors, such as extremely hard physical training. Professional athletes, especially those who compete in combat sports, might have low testosterone levels as a result of fatigue, improper nutrition, lack of rest, etc. it is important to take a look at a patient’s physical condition and training regime to accurately diagnose androgen deficiency. A professional can use special tests to diagnose hypogonadism. It is important to let an experienced healthcare provider assess the testosterone levels to avoid confusion and medical complications. Proper laboratory diagnosis is done early in the morning when testosterone levels are at their peak. Testosterone production follows something called a diurnal rhythm, meaning that the production is higher in the morning and lower at the end of the day. Working night shifts or having poor quality sleep can drastically influence the result of the analysis, so patients should take this into consideration. Similarly, having an acute illness can also render false testosterone diagnosis. It is necessary to perform 2 or more testosterone evaluations to determine if a patient is suffering from hypogonadism or not, since approximately 33% of men have a positive result after one measurement. Evaluating testosterone levels is highly recommended for certain patients, regardless if they experience the hypogonadism symptoms or not. For example, patients with HIV or those who have type 2 diabetes mellitus, osteoporosis or chronic pulmonary disease are also at a higher risk of having low serum testosterone. Once the testosterone levels have been measured and it has been confirmed that the patient might benefit from testosterone replacement therapy, additional endocrinology tests should be performed to determine the nature of the hypogonadism – primary or secondary. Treating hypogonadism accurately is paramount, especially if the patient has certain fertility goals.   Primary and secondary hypogonadism (Low Testosterone)   As mentioned earlier, a low testosterone level in the bloodstream might result from 2 factors. The Leydig cells located in the testes are responsible for producing the majority of testosterone in men. This process takes place using the luteinizing hormone (LH) from the pituitary gland. The LH is also strictly linked to the GnRH which is produced by the hypothalamus. The GnRH is released in a pulsatile manner and a disruption in this process can lead to low testosterone levels over time. To sum it up, men can suffer from primary hypogonadism (the testosterone is not produced in the testes), from secondary hypogonadism (the production of LH or GnRH is disrupted in the pituitary or hypothalamus) or both. If a patient has primary hypogonadism, the LH and FSH levels will be elevated as these hormones are produced by the pituitary and hypothalamus but not properly converted into testosterone. Most specialists recommend karyotype analysis for further investigation. The causes of primary hypogonadism can be multiple and they include HIV, toxins gathered in the body, acquired anorchia, orchitis, and more. On the other hand, if the LH and FSH levels are low, then additional investigations must be done to determine the nature of the secondary hypogonadism. It basically means that the testes are perfectly capable of making testosterone, but they don’t have the primary resource (LH) to do so.   The pituitary gland and problems associated with it   Secondary hypogonadism is a more complicated medical issue and it involves looking at the characteristics of the pituitary gland. There are numerous factors which might cause secondary hypogonadism such as certain types of tumors, untreated sleep apnea, infiltrative diseases, use of certain drugs such as marijuana, opiates, and heroin, etc. Hyperprolactinemia can be a contributing factor in about 5% of secondary hypogonadism. This means that a prolactin adenoma can put pressure on the pituitary gland and cause damage. There are also different types of medications which can affect prolactin secretion, such as metoclopramide and others. In some cases, secondary hypogonadism can be caused by GnRH deficiency which happens as a result of damage to the hypothalamus. This part of the brain can become injured as a result of toxins accumulation, trauma, taking certain types of medication, as well as systemic disease. If a patient is suspected of having secondary hypogonadism, he will receive a full pituitary workup to determine prolactin levels and to see if its secretion is disrupted or not. It is paramount to differentiate between secondary hypogonadism originating in the pituitary and the one originating in the hypothalamus. Men who have fertility goals and want to have children in the near future need a different type of treatment than those who don’t have any fertility goals. There are rare instances when men suffer from a combination of primary and secondary hypogonadism. This might happen as a result of alcohol abuse, sickle cell disease, and more. There are several treatment options available in this case such as spermatogenesis and others.   Exploring Hyperprolactinemia (High Prolactin) and Its Implications in Low Testosterone   It has been discovered that men who suffer from hyperprolactinemia experience a wide variety of symptoms, such as decreased sperm mobility and low libido. These can lead to a low-quality sex life and fertility problems. Even in the presence of relatively normal testosterone levels, hyperprolactinemia can have a significant negative impact on sexual health, leading to erectile dysfunction in worst cases. By normalizing prolactin levels, scientists have discovered that testosterone levels improve and the overall quality of life is enhanced as well. Correct prolactin levels are directly associated with a healthy testosterone metabolism. Therefore, patients who have low serum testosterone should seek treatment for improving prolactin levels first before opting for testosterone replacement therapy. Once it has been discovered that the body responds well to hyperprolactinemia treatment, it might not be necessary to take advantage of testosterone replacement therapy.   Throwing a spotlight on the pituitary and its function   The pituitary gland plays a vital role in the production of testosterone and it should be properly assessed to determine if there are any additional hormonal imbalances present in the body. For example, for men with a testosterone level lower than 150 ng/dL, an evaluation of the anterior pituitary axes is highly recommended. This evaluation can discover other medical conditions, such as hypopituitarism, which might affect proper testosterone production. Testing the pituitary gland should be done early in the morning before 9 am. This is done by drawing blood to measure cortisol levels as well as ACTH. If the patient works night shifts, which might compromise the accuracy of the test, an ACTH stimulant is administered intramuscularly. This test can give insights into the hormonal balance of the patient. For example, if it is suspected that the patient has Cushing syndrome, the doctor might recommend a 1 mg dexamethasone suppression test. If acromegaly is suspected (growth hormone deficiency), then other tests are necessary to determine the exact levels of growth hormone. Such tests are required to determine the full biochemical makeup of the patient in relation to the pituitary gland and hypogonadism. If the results are positive for one or more of those tests, the patient will be redirected to endocrinology for additional measurements.   Pituitary imaging in the diagnosis of low testosterone   Magnetic resonance imaging (MRI) might be used to discover further details about the pituitary gland and this decision is based on multiple tests of the hormone levels. Pituitary imaging is done only when proper clinical management is required and it can be used to discover incidentalomas, which can be 6 mm in diameter or less. These are small bodies that might grow on the pituitary gland and put pressure on it which in turn disrupts the regular flow of hormones required for healthy testosterone production. These incidentalomas are usually found in approximately 20% of autopsies and can also be encountered in up to 10% of the population who is referred to pituitary imaging. The MRI testing of the pituitary should be done on men who have severe secondary hypogonadism (testosterone levels are below 150 ng/dL, persistent hyperprolactinemia, and others). Pituitary imaging isn’t necessary for cases of primary hypogonadism and it is only performed when absolutely necessary.   Learning about thyroid and its role in low testosterone   The thyroid is very important when it comes to testosterone production. In general terms, hypothyroidism has been associated with a decrease in total testosterone levels, while hyperthyroidism might lead to converting too much testosterone into estradiol, which results in impaired sexual function, gynecomastia (enlarged man’s breasts), and other medical conditions. In some cases, hypothyroidism can lead to hyperprolactinemia, but such occurrences are rare. When this happens, improving the thyroid function through certain treatments or medication can stabilize prolactin levels and this, in turn, will normalize testosterone production. Hypothyroidism is also frequently associated with erectile dysfunction. Similarly, hyperthyroidism can also be problematic, as it has been associated with ejaculatory dysfunction, as shown in a study done on over 750 men. More than 50 percent of those who had hyperthyroidism also showed symptoms of reduced sperm mobility and ejaculatory problems. However, when these men received treatment for hyperthyroidism, their fertility and testosterone production improved significantly, which means that testosterone replacement therapy isn't necessarily the go-to treatment for all men suffering from androgen deficiency.   Conclusions   As presented in this article, the human body is very complex, and there might be multiple causes for a low serum testosterone level in the bloodstream on males of all ages. It is important to determine whether the hypogonadism is primary or secondary, as well as perform numerous tests and hormone evaluations to determine the nature of the hypogonadism and to prescribe the correct treatment. In case the pituitary gland is the culprit, MRI tests might be required, though such instances are rare. Certain types of treatments are also recommended if the patient has fertility goals. If none of the other medications and treatments for hypogonadism are accurate, then testosterone replacement therapy might be considered for certain patients. By the way, monitoring serum testosterone, LH, FSH and prolactin is very easy these days thanks to tests that can be bought online at discounted prices. Visit www.discountedlabs.com for more details.

Testosterone Replacement Therapy (TRT) is a common treatment for men with low testosterone levels. While TRT can have numerous benefits, such as increased energy, libido, and muscle mass, it is important to monitor other hormone levels, specifically estradiol and dihydrotestosterone (DHT). While DHT is a metabolite of testosterone, estrogen is a form of estrogen that results from the aromatization of testosterone. Understanding the optimal levels of these hormones on TRT is crucial for achieving the desired effects while minimizing potential side effects. In this article, we will discuss a study conducted on young and older men using different doses of testosterone and its implications for predicting estradiol and DHT levels on TRT. Table of Contents The Study: Testosterone Injections and Estradiol/DHT Levels Results and Findings Estradiol Levels DHT Levels Predictive Model Interpreting the Findings Conclusion The Study: Testosterone Injections and Estradiol/DHT Levels The study in question was conducted by researchers at Boston University School of Medicine and published in the Journal of Clinical Endocrinology & Metabolism in 2010. The aim of the study was to investigate the effects of different doses of testosterone injections on estradiol and DHT levels in young and older men. The participants included 51 young men aged 19 to 35 and 50 older men aged 59 to 75. To conduct the study, the participants were administered a blocker to suppress their natural testosterone production. They were then given weekly injections of different doses of testosterone for a duration of five months. The researchers measured the participants' estradiol and DHT levels throughout the study to assess the impact of testosterone doses on these hormones.     Results and Findings The study revealed several interesting findings regarding estradiol and DHT levels in men on TRT. Here are some key points: Estradiol Levels The study found that estradiol levels increased with increasing doses of testosterone in both young and older men. However, the increase in estradiol was more significant in older men compared to younger men. This suggests that older men may have a higher propensity for aromatization, which is the conversion of testosterone into estradiol. It is important to note that the estradiol levels observed in the study were higher than the reference ranges provided by some laboratories, which are primarily derived from men not on TRT. DHT Levels DHT levels also increased with higher testosterone doses, but the difference between young and older men was not as pronounced as with estradiol. DHT is derived from testosterone through the action of the enzyme 5-alpha reductase. While DHT is often associated with androgenic side effects, such as male pattern baldness and prostate enlargement, its role in TRT is still not fully understood. Predictive Model To help predict estradiol and DHT levels based on testosterone dose, the researchers developed a mathematical model using the data from the study. The model provides equations to estimate estradiol and DHT levels based on total testosterone levels. These equations can be helpful for clinicians and individuals on TRT to better understand and predict their hormone levels. Interpreting the Findings The findings from this study have important implications for individuals on TRT. It is essential to recognize that estradiol levels on TRT may be higher than the reference ranges established for men not on TRT. This is because the reference ranges are typically derived from individuals with lower testosterone levels. It is crucial to consider the individual's specific situation and response to TRT when interpreting estradiol levels. Additionally, the study emphasizes the need for regular monitoring of hormone levels to ensure they are within a safe and optimal range. By measuring estradiol and DHT levels, healthcare providers can make informed decisions regarding dosage adjustments and potential interventions to manage any adverse effects. It is important to remember that individual responses to TRT can vary, and what may be considered an optimal hormone level for one person may not be the same for another. Factors such as age, overall health, and personal preferences should be taken into account when evaluating hormone levels and making treatment decisions. Conclusion Understanding the impact of testosterone replacement therapy on hormone levels, particularly estradiol and DHT, is crucial for optimizing the benefits and minimizing the risks associated with TRT. The study discussed in this article provides valuable insights into the effects of different testosterone doses on estradiol and DHT levels in men. It is essential for individuals on TRT to work closely with healthcare professionals who can monitor hormone levels regularly and guide them in making informed decisions about their treatment. The predictive model developed in the study can serve as a helpful tool in estimating estradiol and DHT levels based on testosterone dose, but individual variations should always be taken into account. By monitoring hormone levels and adjusting treatment accordingly, individuals on TRT can achieve the desired effects while minimizing potential side effects. Regular communication with healthcare providers is key to ensuring the effectiveness and safety of testosterone replacement therapy. Disclaimer: The information in this article is based on the findings of a specific study and should not replace personalized medical advice. Individuals on TRT should consult with qualified healthcare professionals to address their specific needs and concerns.    

Testosterone is more than just a sex hormone. It plays a crucial role in a range of physiological processes, including the development of muscle mass, bone density, and even the modulation of blood sugar levels. While high levels of testosterone can have their own set of complications, this article focuses on the often-underestimated risks associated with low testosterone levels. What is Low Testosterone? Low testosterone is a condition where the body does not produce sufficient amounts of the hormone. The threshold for low testosterone varies, but it is generally considered to be below 300 ng/dL (nanograms per deciliter) for adult men. The condition can lead to various health issues, ranging from metabolic syndrome to increased risk of death from all causes. Understanding the Causes of Low Testosterone:  Testosterone, the primary male sex hormone, plays a crucial role in maintaining a range of bodily functions, from muscle mass and fat distribution to bone density and red blood cell production. While it's common for testosterone levels to decline as men age, significantly low levels can lead to a host of health issues. But what causes low testosterone levels? The reasons are many and can range from genetic conditions to lifestyle choices. Let's break it down. Secondary Causes: Hypothalamic-Pituitary Dysfunction Idiopathic GnRH Deficiency, Kallman Syndrome, and More Sometimes, low testosterone can be due to issues with the pituitary gland or the hypothalamus, parts of the brain that signal the testicles to produce testosterone. Conditions such as Idiopathic GnRH deficiency and Kallman syndrome can disrupt these signals. These conditions are examples of hypogonadotropic hypogonadism (Bhasin et al., 2010). Inflammatory Causes Inflammation of the pituitary gland can also result in low testosterone. This inflammation can be due to a variety of factors, including autoimmune reactions and certain illnesses (Dandona & Rosenberg, 2010). Trauma and Tumors Blunt head trauma or postsurgical complications can affect the pituitary gland, leading to low testosterone. Tumors like pituitary adenomas or craniopharyngiomas can have similar effects (Wu et al., 2010). Vascular Insult Issues with the blood vessels that supply the pituitary, such as pituitary infarct/apoplexy or carotid aneurysm, can also be a culprit. Drug-Induced Causes Certain medications like anabolic steroids, opioids, and drugs that induce hyperprolactinemia can contribute to low testosterone. Always consult your doctor if you are on medication and experiencing symptoms of low testosterone (Bhasin et al., 2010). Systematic Illness and Autoimmune Causes Chronic illnesses such as anorexia nervosa, chronic renal failure, and liver failure can result in low testosterone. Autoimmune conditions that attack the pituitary gland (autoimmune hypophysis) can also be a factor (Dandona & Rosenberg, 2010). Primary Cause: Testicular Dysfunction Chromosomal and Genetic Factors Issues right at the level of the testicles can also be causes. Conditions like Klinefelter's syndrome, XX male gonadal dysgenesis, and defects in androgen biosynthesis are all chromosomal abnormalities that can lead to low testosterone (Wu et al., 2010). Infections and Surgeries Orchitis (inflammation of the testicles due to infections like mumps or HIV) and orchiectomy (surgical removal of the testicle) can directly affect testosterone production. Other Factors Chronic infections like tuberculosis, irradiation, testicular torsion, and certain medications can also be responsible. Lifestyle and Other Factors Factors like obesity, aging, malnutrition, and exposure to toxins such as heavy metals and alcohol can also influence testosterone levels (Dandona & Rosenberg, 2010). Low testosterone can result from a variety of causes, ranging from medical conditions and medications to lifestyle choices. If you're experiencing symptoms, it's crucial to consult a healthcare provider for a comprehensive diagnosis and treatment plan. Risks Associated with Different Levels of Low Testosterone < 450 ng/dl (15.3 nmol/l) - Risk of Metabolic Syndrome Metabolic syndrome is a cluster of conditions that include high blood pressure, elevated blood sugar levels, excess body fat, and abnormal cholesterol levels. Testosterone plays a significant role in regulating these physiological functions. Research by Dhindsa et al. has highlighted the increased risk of metabolic syndrome in men with testosterone levels below 450 ng/dl1. < 400 ng/dl (15.3 nmol/l) - Venous Leakage (Internal Penile Damage) Risk Venous leakage is a condition that can result in erectile dysfunction due to internal penile damage. According to a study by Yassin and Saad, men with testosterone levels below 400 ng/dl are at a higher risk of developing this condition2. < 350 ng/dl (11.9 nmol/l) – All-Cause Death Risk and Anemia Risk Khaw et al. conducted a study that showed men with testosterone levels below 350 ng/dl had an increased risk of death from all causes, as well as a higher risk of developing anemia3. < 300 ng/dL (10.2 nmol/L) - Lowered Libido, Weight Gain & Diabetes Risk Increased A low level of testosterone can also have a detrimental effect on sexual health, including a decrease in libido. Furthermore, it is associated with weight gain and an increased risk of developing diabetes. Traish et al. discussed these risks in their research4. < 300 ng/dL (10.2 nmol/L) - Quartile Risk of Fractures (Osteoporosis), Memory-Related Issues & Depression Risk Increases Testosterone is crucial for bone density. Low levels can increase the risk of fractures, memory-related issues, and even depression. A study by Orwoll et al. emphasized these risks5. < 250 ng/dl (8.5 nmol/l) - Arterial Plaque (Arteriosclerosis) & Sleep Quality Affected Vlachopoulos et al. found that men with testosterone levels below 250 ng/dl had a higher risk of developing arterial plaque, which can lead to arteriosclerosis. Additionally, these men experienced a reduction in sleep quality6. < 235 ng/dl (8.0 nmol/l) - Hardening of Arteries (Dialysis Patients) Carrero et al. identified that low testosterone levels can increase the mortality risk among male dialysis patients by promoting the hardening of arteries7. < 200 ng/dl (6.8 nmol/l) - Morning Erections Decrease A study by O'Connor et al. showed that men with testosterone levels below 200 ng/dl experienced a decrease in morning erections, which is often a sign of erectile dysfunction8. < 150 ng/dl (5.1 nmol/l) - Increased Inflammation (TNF-alpha) Malkin et al. found that extremely low levels of testosterone, under 150 ng/dl, were associated with increased inflammation markers like TNF-alpha9. Conclusion Low levels of testosterone are linked to a wide range of health issues. While testosterone replacement therapy is often recommended for men with low levels, understanding the risks associated with varying degrees of low testosterone is crucial for effective treatment and prevention. Always consult your healthcare provider for diagnosis and treatment.   Buy a Low Cost Total and Free Testosterone Test on DiscountedLabs.com: Testosterone test near me.   Low Testosterone: What Do Different Medical Guideline Groups Say? Understanding the guidelines for diagnosing and treating low testosterone is crucial for both healthcare providers and patients. Different medical organizations have released various guidelines over the years, making it essential to know how each defines low testosterone levels. This article aims to shed light on what various medical guideline groups have to say about low testosterone, focusing on cutoff values and expert opinions. Expert Opinion Before delving into specific guidelines, it's worth noting that expert opinion often plays a significant role in forming these guidelines. Medical professionals and researchers contribute to these guidelines based on clinical experience, existing studies, and ongoing research. Therefore, guidelines are not static but evolve over time, reflecting the current state of medical knowledge. Year of Release and Update Knowing when a particular guideline was released or updated is important as it indicates the currency and relevancy of the information. Here is a brief timeline:   ISSAM: 2005 Endocrine Society: 2006 ISSM: 2008 AUA: 2015 ICSM: 2015, updated in 2018  Cutoff Values of Testosterone for Laboratory Diagnosis One of the most critical aspects of diagnosing low testosterone is determining the cutoff values. Various organizations have different parameters. Here's a summary: Guideline Group Cutoff Values for Total T (TT) Cutoff Values for Free T Year ISSAM TT < 231 ng/dL (8 nmol/L) N/A 2005 Endocrine Society TT: 231-346 ng/dL (8-12 nmol/L) Free T < 52 pg/mL 2006 ISSM TT < 230 ng/dL (8 nmol/L) Free T < 52 pg/mL 2008 AUA TT: 230-350 ng/dL (8-12 nmol/L) Free T < 65 pg/mL 2015 ICSM TT < 300 ng/dL Free T < 5 ng/dL 2018 Definitions and Abbreviations: ISSAM: International Society for the Study of the Aging Male ISSM: International Society for Sexual Medicine ICSM: International Consultation for Sexual Medicine AUA: American Urological Association TT: Total Testosterone Free T: Free Testosterone SHBG: Sex Hormone-Binding Globulin Understanding the various guidelines for diagnosing low testosterone is crucial for appropriate treatment. It's evident that different medical organizations have varying cutoff values, and these may be subject to change as more research becomes available. Always consult your healthcare provider for the most current and personalized advice. By keeping updated on these guidelines, both physicians and patients can make more informed decisions regarding the diagnosis and treatment of low testosterone. Sources: International Society for the Study of the Aging Male (ISSAM), Guidelines, 2005. Endocrine Society, Clinical Guidelines, 2006. International Society for Sexual Medicine (ISSM), Guidelines, 2008. American Urological Association (AUA), Guidelines, 2015. International Consultation for Sexual Medicine (ICSM), Guidelines, 2015, updated in 2018.   Footnotes Dhindsa, S., Miller, M. G., McWhirter, C. L., Mager, D. E., Ghanim, H., Chaudhuri, A., & Dandona, P. (2010). Testosterone concentrations in diabetic and nondiabetic obese men. Diabetes Care, 33(6), 1186-1192. PubMed ↩ Yassin, A. A., & Saad, F. (2017). Testosterone Deficiency and Testosterone Treatment in Older Men. Gerontology, 63(2), 144–156. PubMed ↩ Khaw, K. T., Dowsett, M., Folkerd, E., Bingham, S., Wareham, N., Luben, R., ... & Day, N. (2007). Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men. Circulation, 116(23), 2694-2701. PubMed ↩ Traish, A. M., Saad, F., & Guay, A. (2009). The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction. Journal of Andrology, 30(1), 10-22. PubMed ↩ Orwoll, E., Lambert, L. C., Marshall, L. M., Phipps, K., Blank, J., Barrett-Connor, E., ... & Cummings, S. (2006). Testosterone and estradiol among older men. The Journal of Clinical Endocrinology & Metabolism, 91(4), 1336-1344. PubMed ↩ Vlachopoulos, C., Ioakeimidis, N., Miner, M., & Aggelis, A. (2014). Testosterone deficiency: a determinant of aortic stiffness in men. Atherosclerosis, 233(1), 278-283. PubMed ↩ Carrero, J. J., Qureshi, A. R., Parini, P., Arver, S., Lindholm, B., Bárány, P., ... & Stenvinkel, P. (2009). Low serum testosterone increases mortality risk among male dialysis patients. Journal of the American Society of Nephrology, 20(3), 613-620. PubMed ↩ O'Connor, D. B., Lee, D. M., Corona, G., Forti, G., Tajar, A., O'Neill, T. W., ... & EMAS Study Group. (2011). The relationships between sex hormones and sexual function in middle-aged and older European men. The Journal of Clinical Endocrinology & Metabolism, 96(10), E1577-E1587. PubMed ↩ Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004). The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. The Journal of Clinical Endocrinology & Metabolism, 89(7), 3313-3318. PubMed ↩

Testosterone is an essential hormone in both males and females, but it plays a particularly crucial role in male development and reproductive health. Testosterone levels can fluctuate throughout life, and low testosterone levels can have a significant impact on overall well-being. Getting a testosterone blood test can provide valuable information about hormone levels and help diagnose any underlying conditions or imbalances. Here are some reasons why getting a testosterone blood test is important and the difference between the available testosterone test assays in the market. Table of Contents The Importance of Getting a Testosterone Blood Test 1. Diagnosing Hypogonadism 2. Monitoring Hormone Replacement Therapy 3. Identifying Underlying Health Conditions 4. Assessing Fertility 5. Monitoring Overall Health Differences, Advantages, and Disadvantages of Different Testosterone Tests 1. At-Home Testosterone Kits 2. Saliva Testosterone Test 3. LC/MS/MS Total Testosterone Test 4. Immunoassay-Based Testosterone Test Citations: The Importance of Getting a Testosterone Blood Test 1. Diagnosing Hypogonadism Hypogonadism is a condition characterized by low testosterone levels, which can lead to a range of symptoms such as fatigue, decreased libido, erectile dysfunction, and mood changes. A testosterone blood test is the primary method used to diagnose hypogonadism[1]. Identifying and treating hypogonadism can help improve quality of life and alleviate symptoms. 2. Monitoring Hormone Replacement Therapy Testosterone replacement therapy (TRT) is a common treatment for individuals with low testosterone levels. Regular monitoring of testosterone levels through blood tests is essential to ensure that the therapy is effective and that hormone levels are within the optimal range. Adjustments to the dosage or treatment plan can be made based on the results of these tests[1]. 3. Identifying Underlying Health Conditions Low testosterone levels can sometimes be a symptom of an underlying health condition, such as pituitary gland disorders, testicular tumors, or chronic illnesses. A testosterone blood test can help identify these conditions and guide further diagnostic investigations[2]. 4. Assessing Fertility Testosterone plays a crucial role in sperm production and male fertility. Low testosterone levels can contribute to infertility. A testosterone blood test can provide valuable information about hormone levels and help determine the potential causes of infertility[2]. 5. Monitoring Overall Health Testosterone levels can be an indicator of overall health and well-being. Low testosterone levels have been associated with an increased risk of cardiovascular disease, metabolic syndrome, and osteoporosis. Regular testosterone blood tests can help identify any potential health risks and allow for early intervention and treatment[1]. It is important to note that testosterone blood tests should be conducted by healthcare professionals and interpreted in the context of an individual's symptoms, medical history, and other relevant factors. At-home test kits may provide convenience, but they cannot diagnose underlying health conditions or provide a comprehensive assessment of hormone levels[2]. Differences, Advantages, and Disadvantages of Different Testosterone Tests 1. At-Home Testosterone Kits    - Collection Method: At-home testosterone kits typically involve collecting a blood or saliva sample using a finger prick or saliva swab.     - Advantages:      - Convenience: At-home testosterone kits provide the convenience of testing testosterone levels from the comfort of your own home.      - Privacy: Some individuals may prefer the privacy of conducting the test at home.     - Disadvantages:      - Limited Accuracy: At-home testosterone kits may have limitations in terms of accuracy and reliability compared to tests conducted in a clinical setting.      - Lack of Professional Interpretation: Results from at-home kits may not come with professional interpretation, requiring individuals to seek medical advice for proper understanding and guidance. 2. Saliva Testosterone Test    - Collection Method: Saliva testosterone tests involve collecting a saliva sample using a swab or collection device.    - Advantages:      - Non-Invasive: Saliva testosterone tests are non-invasive and can be easily self-administered.      - Convenient: Saliva samples can be collected at any time and do not require a blood draw.    - Disadvantages:      - Limited Availability: Saliva testosterone tests may not be as widely available as blood tests.      - Potential Variability: Saliva testosterone levels may not always accurately reflect total testosterone levels in the blood. 3. LC/MS/MS Total Testosterone Blood Test    - Collection Method: The LC/MS/MS (Liquid Chromatography-Mass Spectrometry) total testosterone test requires a blood sample typically collected from a vein in the arm.    - Advantages:      - High Accuracy: LC/MS/MS is considered a highly accurate method for measuring total testosterone levels.      - No Upper or Lower Limit: Unlike the immunoassay testosterone test, the LC/MS testosterone test is accurate at very low or very hight testosterone blood levels.    - Widely Accepted: LC/MS/MS is a commonly used method in clinical settings for testosterone testing.    - No interference by supplements like biotin.    - You can buy the LC/MS testosterone test on DiscountedLabs.com    - Disadvantages:      - Requires a Blood Draw: Some individuals may find the process of having blood drawn uncomfortable or inconvenient.     - Laboratory Processing Time: Results from LC/MS/MS tests may take longer to obtain compared to rapid tests. 4. Immunoassay-Based Testosterone Blood Test    - Collection Method: Immunoassay-based testosterone tests also require a blood sample, typically collected from a vein in the arm.    - Advantages:      - Rapid Results: Immunoassay-based tests can provide relatively quick results.      - Cost-Effective: Immunoassay-based tests are generally more cost-effective compared to LC/MS/MS tests .    - Disadvantages:      - Potential for Interference: Immunoassay-based tests may be susceptible to interference from certain substances or conditions, potentially affecting accuracy.      - Lower Sensitivity: Immunoassay-based tests may have lower sensitivity compared to LC/MS/MS tests. It is important to note that the choice of testosterone test should be made in consultation with a healthcare professional. They can guide you in selecting the most appropriate test based on your specific needs, medical history, and the accuracy and reliability of the available testing methods. BUY TESTOSTERONE TESTS Citations: 1] Diagnosis and Treatment of Hypogonadism in Men [2] Testosterone Test: What It Is and What the Results Mean [3] Testosterone Levels Test [4] Testosterone Treatments: Why, When, and How? [5] Low Testosterone [6] Criteria for Low Testosterone as a Public Health Issue [7] Testosterone Tests [8] Clinical Interpretation of Testosterone Test Results [9] Testosterone Test: Types and Interpretation [10] At-Home Testosterone Test: Overview and Information [11] Understanding Testosterone Levels Test [12] Everlywell: At-Home Testosterone Test

Key Highlights Understand the importance of sensitive estradiol testing for hormone therapy and men's health. Learn about the benefits of choosing discounted labs for your estradiol sensitive test. Discover the differences between standard and sensitive estradiol tests, including the testing methodologies involved. Prepare effectively for your estradiol sensitive test by following specific guidelines. Get insights into interpreting and understanding your estradiol test results with the help of healthcare providers. Explore the convenience of ordering your estradiol sensitive test online and what to expect during the process. Introduction Estradiol is an important hormone for both men and women. It affects many parts of our health. It plays a significant role in maintaining bone health, cognitive functions, sex drive, and overall body composition in both genders. It is especially important to understand estradiol in men's health. There are many myths about estradiol in men. This makes it essential to have accurate testing. Choosing a sensitive estradiol test can give clear information about hormonal levels. This allows for quick action if needed. This blog looks at the benefits of discounted labs for these tests. It also helps you know how to order and prepare for a sensitive estradiol test. Understanding Estradiol and Its Importance for Men Estradiol plays an important role in men's health. As the hormone responsible for developing and regulating the male reproductive system, it affects many body functions, including bone strength, sex drive, and mood. Understanding estradiol is crucial because imbalances in levels can lead to issues such as weaker bones, changes in sex drive, and hormone imbalances. That's why it is important to regularly check estradiol levels through tests to identify any potential concerns that may require medical attention. The Role of Estradiol in Male Health Estradiol is very important for men’s health, even though it is mostly known as a hormone for women. In men, estradiol helps keep bones strong, manage sexual desire, and support heart health. It also plays a key role in mood, thinking, and making proteins. Moreover, estradiol helps control the production of testosterone. If the levels of estradiol are not right, it can cause health problems. This shows how important it is to know about and check this hormone in men's health. Common Misconceptions About Estradiol in Men Estradiol is important for men's health, not just a hormone for women. Men can also experience problems with estradiol levels, which can affect their well-being. One common myth is that all types of estrogen are bad for men. In fact, having the right amount is key for good health. Another myth is that high estradiol always causes harm. Both low and high levels can negatively impact men's health. Knowing the truth about these myths can help people make better choices for their health care. Why Opt for a Sensitive Estradiol Test? Find out important hormonal imbalances with a sensitive estradiol test. This test gives specific results that normal tests may overlook. It helps in making accurate health evaluations. Differences Between Standard and Sensitive Estradiol Tests Standard estradiol tests check a wide range of estradiol levels in the blood. This gives a general view of hormone levels. On the other hand, sensitive estradiol tests use advanced methods like liquid chromatography and mass spectrometry, also known as immunoassay estradiol test. These methods help find low levels of estradiol with more accuracy, making it a highly sensitive estradiol test. The LC-MS estradiol test is primarily suggested for situations with very low estrogen levels. The sensitive test is better for people who need careful hormonal analysis. While standard tests can work well in many cases, sensitive tests give more detailed information. This is especially true for those with mild hormone imbalances. Choosing the right test depends on how much detail you need about estradiol levels. Identifying Symptoms of Estradiol Imbalance Estradiol imbalances can show different symptoms. In men, low estradiol levels may cause a lower sex drive and tiredness. High estradiol levels can result in male feminization. Both men and women may have dry skin and hormonal changes. Due to changes in estradiol levels, which birth control pills can also affect, women may experience irregular menstrual cycles or fertility issues. It's important to notice these signs and get estradiol testing to fix any imbalances quickly. Symptoms are key indicators showing the need to check for possible estradiol imbalances. Stay aware of these signs to keep good health. The Benefits of Using Discounted Labs for Buying Your Estradiol Sensitive Test Online Discounted labs provide a cheap way to get your estradiol test without losing quality. They have lab locations all over the country, making it easy for you to access their services. By using discounted labs, you save money while getting accurate test results. This is a great option for people looking for affordable healthcare. These labs give you a wallet-friendly choice without lowering the dependability and accuracy of your test results. Using discounted labs can help you monitor your estradiol levels easily and conveniently. Affordability Without Compromising Quality Discounted labs provide lowest cost estradiol sensitive teststhat are still high quality. These affordable options help you take care of your health without spending too much money. When you choose discounted labs, you get reliable results while saving cash. Being affordable does not mean you lose accuracy or dependability. These labs follow strict quality rules to give you trustworthy results that you can rely on. Caring for your health should not cost a lot, and discounted labs make great testing cheap and easy to get. You can pick affordable options without losing quality in your healthcare experience. Nationwide Lab Locations for Your Convenience Find it easy to access lab locations for your sensitive estradiol test. You can place a simple order online and choose the testing laboratory near you. There is a large network of collection sites to make your testing process smooth and quick. You will enjoy the ease of getting your blood sample taken at a place that works best for you. This saves you time and effort. Whether you’re in a busy city or a small town, you can find the closest lab location for your estradiol test at our nationwide reference lab locations without any trouble. How to Order Your Estradiol Sensitive Test Online To get your Estradiol Sensitive Test online, go to Discounted Labs's Sensitive Estradiol product page. Find the test in the menu and add it to your shopping cart. Next, go to checkout and fill out the information needed. After you place your order, you will get a confirmation email with instructions on how to download your lab request. Then, relax while the lab processes your lab request and gets ready for your test. It’s easy to take control of your health with just a few clicks. Simple Steps to Secure Your Test To get started, go to our website and pick the "Estradiol Sensitive Test" from our list of lab tests. Add the test to your shopping cart. Then, go to the checkout. Fill in the needed details and choose the closest lab location that works for you. After you pay, you will get a lab order to take with you to the lab. Don't worry, the process is easy and helps check your estradiol levels accurately through secure and reliable repeat testing. What to Expect After Placing Your Order When you order the sensitive estradiol test online, you will get a quick confirmation email about your purchase. Usually, the test kit will be sent to your address fast. Once you get it, follow the instructions it comes with to collect your sample. Then, send the sample back as directed for testing. Your results will be processed quickly, and you will receive them safely by email within the set time. You can feel confident that your experience with the sensitive estradiol test is simple and easy. Preparing for Your Estradiol Sensitive Test Prepare well for your Estradiol Sensitive Test by following these simple steps. First, talk to your healthcare provider for any special instructions. It is important to schedule this test during the follicular phase of your menstrual cycle and avoid taking any medication that might alter your estradiol levels during this time, such as birth control pills. Also, let the lab know if you are taking any medication that might change your estradiol levels. Make sure to arrive at the collection site well-hydrated. This will make the blood draw easier. By knowing these steps, you will get correct and trustworthy results from your test. Understanding the luteal phase of your menstrual cycle is also important in interpreting your estradiol levels, as they will naturally fluctuate during this time. Understanding Your Test Results Estradiol test results give important information about the hormone levels in your body, especially for individuals with conditions such as liver disease. This sensitive test provides detailed facts for your healthcare provider. Knowing the levels of estradiol is key because they can show if there are hormone imbalances or other health problems. These levels can also affect things like bone health, sex drive, and your overall well-being. Understanding these results can be complex, so it's important to talk to your healthcare provider. They can help you make sense of your estradiol test results. Conclusion Regularly checking estradiol levels is important for men's health. You can choose a sensitive estradiol test online to learn more about your hormone balance. Discounted labs provide easy and affordable options while still offering good quality. You can easily order your test online and prepare by following simple steps. Knowing your test results is key to spotting any hormone imbalance. Take control of your health today to keep your hormone levels at their best for your overall well-being and energy.   References The role of estradiol in male reproductive function Estradiol in Men- Myths and Realities Role of Estradiol (Estrogen) in Men and Its Management