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Women and men living with fibromyalgia do not have characteristic or consistent abnormalities on laboratory testing. However, routine laboratory and imaging studies are important to help rule out diseases with similar manifestations and to assist in diagnosis of certain inflammatory diseases that frequently coexist with fibromyalgia. These are the lab tests commonly checked by physicians treating fibromyalgia patients: CMP, CBC, Urinalysis, TSH, Vitamin D & B-12, Iron/TIBC, Magnesium in RBC, ESR, CPK and Ferritin.

The Rheumatoid Arthritis Factor is often evaluated in patients suspected of having any form of arthritis or destructive articular disease even though positive results can be due to other causes, and negative results do not rule out disease. But, in combination with signs and symptoms, it can play a role in both diagnosis and disease prognosis. It is part of the usual disease criteria of rheumatoid arthritis.