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CPK is creatine phosphokinase, an enzyme in the heart, brain, and skeletal muscle. High CPK can indicate muscle destruction, heart attacks, and central nervous system issues. Long-term exposure to high CPK can load up your kidneys and cause muscle loss and weakness. Sometimes we have no symptoms when CPK is high, but most of the time, we have body aches and soreness. Resistance training can raise CPK, so stop working out for at least five days before the CPK test.