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The adrenal gland produces a hormone known as dehydroepiandrosterone (DHEA). It is also made in the brain. DHEA leads to the production of androgens and estrogens (male and female sex hormones). DHEA levels in the body begin to decrease after age 30. Lower DHEA levels are found in people with hormonal disorders, HIV/AIDS, Alzheimer's disease, heart disease, depression, diabetes, inflammation, immune disorders, and osteoporosis. Corticosteroids, birth control taken by mouth, and agents that treat psychiatric disorders may reduce DHEA levels.

This test for adrenal insufficiency includes 4 measurements of your salivary Cortisol level during one day. Cortisol, also known as the "stress hormone" can be either too high or too low which may be a sign of adrenal distress.

Cortisol (hydrocortisone) is the most prominent glucocorticosteroid, and it is essential for the maintenance of several body functions. The most important physiological effects of cortisol are that it raises blood sugar levels (enhances gluconeogenesis, or breaks down glucose) and lowers inflammation and the immune system.

Discounted Labs’ basic adrenal insufficiency panel includes cortisol, ACTH, and DHEA as a starting point. Depending on lab test results from this panel, physicians may choose to do an ACTH stimulation test, renin, potassium, and sodium. Imaging studies like a CT scan of the adrenal glands may also be considered to check for adrenal growths. In order to check for Addison's Disease, the auto-immune type of primary adrenal insufficiency, labs should be drawn to check 21-hydroxylase