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The cystatin C test (which also includes estimated creatinine clearance eGFR) can be done along with the creatinine or creatinine clearance test in cases where those tests aren’t appropriate, such as patients taking creatine supplements for bodybuilding. These supplements can increase creatinine and decrease creatinine clearance, which can alarm doctors who fear kidney dysfunction.  This creatinine increase is not clinically relevant, but running a Cystatin C test can give physicians reassurance and allow the patient to keep taking that effective bodybuilding supplement.