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 Progesterone is a female hormone important for the regulation of ovulation and menstruation. It is also present in men in smaller concentrations. Progesterone is a steroid hormone that plays numerous roles within the human body. It is crucial to the production of sex hormones and corticosteroids, as well as playing a role as a neuro-steroid (brain function). 

The adrenal gland produces a hormone known as dehydroepiandrosterone (DHEA). It is also made in the brain. DHEA leads to the production of androgens and estrogens (male and female sex hormones). DHEA levels in the body begin to decrease after age 30. Lower DHEA levels are found in people with hormonal disorders, HIV/AIDS, Alzheimer's disease, heart disease, depression, diabetes, inflammation, immune disorders, and osteoporosis. Corticosteroids, birth control taken by mouth, and agents that treat psychiatric disorders may reduce DHEA levels.

SHBG (sex hormone binding globulin) binds to testosterone and estradiol. High SHBG may decrease free testosterone and free estradiol.