Creatine Kinase (CK) or CPK , Total Plus Isoenzymes Test

Creatine Kinase (CK), Total Plus Isoenzymes Test

First time customer? Read How Discounted Labs Works 

IMPORTANT NOTICE ABOUT DISCOUNTED LABS SERVICES: We currently serve the following states:

Alabama, Arizona, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nebraska, Nevada, North Carolina, New Mexico, Ohio, Oregon, Pennsylvania, South Carolina, Tennessee, Texas, Utah, Virginia, Washington, and West Virginia.

Other states will be added in the coming months, so please subscribe to our newsletter on the website footer to be notified.

You will earn 61 Points for purchasing this product.

This lab test panel includes Total CK (or CPK) and relative percentage of BB (CK-1), MB (CK-2), and MM (CK-3); the percentage of macro CK, if present. The CK or CPK isoenzyme test is used to diagnose myocardial infarction (MI). Three fractions normally may be found, each an isoenzyme:

• MM is found in normal serum.

• MB is the myocardial fraction associated with MI and occurs in certain other states. MB can be used in the estimation of infarct size.

CPK stands for creatine phosphokinase and it's an important enzyme produced by your body. Sometimes it's also referred to as creatine kinase (CK) and this enzyme helps doctors discover specific injuries or diseases in the human body.

You can test your CPK levels with a simple blood test. This enzyme is found in nearly all tissues and organs in the human body. However, it branches out into 3 different categories that help doctors distinguish where there is inflammation and why.

Keep reading this article to learn more about CPK, its normal values in adults, and what to do if they get high.

The Basics of the CPK Test

Creatine phosphokinase is divided into 3 main categories such as CPK 1, CPK 2, and CPK 3. Each of these categories is associated with specific organs and body parts. In other words, you'll find more of a particular CPK isoenzyme in certain organs and less of it in the rest of the body. For example:

  • CPK 1 is primarily found in your lungs and brain
  • CPK 2 is primarily found in the heart and its muscles
  • CPK 3 is primarily found in skeletal muscle

When you order a CPK blood test, you will receive a result depending on how much CPK has leaked in your bloodstream as a result of injury or disease.

The normal range of CPK in males is between 39 and 308 U/L and the normal range for females is from 26 to 192 U/L. If your test results indicate that you're above the normal ranges, more tests might be required to determine why specific tissues or organs have been damaged lately.

What Does the CPK Plus Isoenzymes Blood Test Panel Include?

This lab test panel includes Total CK (or CPK) and relative percentage of BB (CK-1), MB (CK-2), and MM (CK-3); the percentage of macro CK, if present.

The CK or CPK isoenzyme test is used to diagnose myocardial infarction (MI). Three fractions normally may be found, each an isoenzyme:

  • MM is found in normal serum.
  • MB is the myocardial fraction associated with MI and occurs in certain other states. MB can be used in the estimation of infarct size.

MB increases have been reported with entities that cause damage to the myocardium, such as myocarditis, some instances of cardiomyopathy, and with extensive rhabdomyolysis, Duchenne muscular dystrophy, malignant hyperthermia, polymyositis, dermatomyositis, mixed connective tissue disease, myoglobinemia, Rocky Mountain spotted fever, Reye syndrome, and rarely in rheumatoid arthritis with high titer RF.2 CK-MB does not generally abruptly rise and fall in such nonacute MI settings, as it does in acute myocardial infarct (AMI).

  • BB is rarely present. BB has been described as a marker for adenocarcinoma of the prostate, breast, ovary, colon, adenocarcinomas of gastrointestinal tract, and for small cell anaplastic carcinoma of lung. BB has been reported with severe shock and/or hypothermia, infarction of bowel,3 brain injury, stroke, as a genetic marker in some families with malignant pyrexia, and with MB in alcoholic myopathy.

Exercise, intramuscular injections, myxedema, grand mal seizures, prior trauma or surgery, and acute MI very early or late lead to the combination of increased total CK but usually normal CK-MB. Increased CK-MB has been described in marathon runners without MI. CK isoenzyme analysis is not usually practical when the total CK is very low, although, in elderly people with low muscle mass, the use of sensitive mass concentration assays may be useful. A single CK isoenzyme examination may be misleading. 

Why Should You Order A CPK Blood Test?

In many cases, doctors recommend a CPK test in case of emergency such as when you're having severe chest pains. A CPK test is a quick way to detect heart attacks, heart injury, issues with the heart muscle, and other similar problems.

At the same time, CPK is also found in skeletal muscle. If too much of a specific CPK isoenzyme is found in your body, this could indicate a disease affecting your muscles. For example, dermatomyositis is a type of disease that affects mostly your skin and muscles.

Elevated CPK levels might also indicate polymyositis which is a condition that gradually weakens the muscles in your body. Some health issues also cause frequent muscle contractions and the only way to confirm a diagnosis is through a CPK test.

If you have heart, muscle, or lung symptoms that bother your daily life, a CPK test is highly recommended. In some cases, you might not have symptoms at all, but this test can help discover silent ailments before they get too serious.

What To Do if CPK Levels Are High?

As mentioned earlier, the only way you can tell if you have high CPK levels is through a blood test. If the results come back and your numbers don't fit the normal range, don't despair. There are many natural ways you can lower your CPK levels naturally.

Obviously, you should also discuss your results with your doctor. Your primary healthcare provider might order additional tests to find out if you have a life-threatening disease or not. In the meantime, here's how you can gradually lower your CPK levels.

Lower Your Cholesterol Levels with Proper Dieting

Cholesterol is a waxy substance produced by your liver, it's essential to keep your veins and arteries flexible and healthy. It also participates in the process of building new body cells. However, too much of it can create deposits inside your blood vessels and this might lead to heart disease and stroke.

If your CPK 2 levels come back high, you should adjust your diet to reduce cholesterol in your body and prevent further damage. For example, try eating foods that lower your cholesterol levels such as oats, grapes, apples, beans, nuts, and strawberries.

At the same time, you could also reduce the amount of fat you eat every day. For example, switch to low-fat yogurt, avoid fatty cheese, and get rid of butter from your fridge. Too much fat puts additional strain on your cardiovascular system.

Get an Omega 3 Fatty Acid Supplement

Omega 3 fatty acids are essential for the health of your health and muscles. You can get this type of nutrient from fatty fish, nuts, and eggs, but most people don't get enough of it through diet only. You might want to consider taking a supplement to protect your heart against further damage.

Reduce Your Salt Intake

For many people, too much salt can lead to increased blood pressure. High blood pressure is a silent killer that can lead to heart disease and damage to the blood vessels. Try to reduce your salt intake as much as possible. Most foods already have enough salt added, so it's not necessary to add more by yourself.

Take a Break from Your Workouts

Believe it or not, it is possible to raise your CPK levels by working out too intensely for too long. Frequent workouts where you push yourself to the limit increase the levels of CPK in your body. You can reverse that by simply taking a break from your workouts.

Regular days of rest are highly recommended, even among top athletes. You need to give your body some time to rest and recover. Taking a few days off from weights is usually enough to significantly reduce your CPK levels, at least for a while.

Now It's Time to Test Your CPK Levels

The CPK isoenzymes are accurate predictors when it comes to damage to your lungs, heart, and muscles. It's important to do this test and see how prone your body is to become ill in the near future.

Go to and order the CPK Test today! This supplier sells some of the most affordable blood tests out there and you will get the results by email in just a few business days. It's that simple.


  1. Go to the "Find a Location" page to find the closest lab location. No need to make an appointment since walk-ins are welcomed. Once you have identified your closest location, go to step 2.

  2. Go to "Choose a Test" and add your selection (s) in the shopping cart. If you prefer to save money on bundled tests, we have created "Lab Test Panels" that can help you decide what to order.

  3. If you have a discount coupon code, add it to your cart.

  4. A $8 lab processing fee will be added to your total.

  5. Pay using a credit card.

  6. You will receive an order confirmation and instructions email on how to download your lab request.

  7. Print lab request form that you downloaded.

  8. Take that form to the closest location. Get your blood drawn.

  9. You will receive an email when the results are ready for you to download.

    Note: You cannot place an order under someone else's profile. The profile person's name will appear on the lab order form.


    If you have further questions, please email [email protected].