Free Estradiol (Sensitive)
This test measures the free (unbound to SHBG or albumin) estradiol and total sensitive estradiol in blood. The test is performed using liquid chromatography/mass spectrometry (LC/MS). NOTE: This test is a send out test to Quest's Nichols Institute San Juan Capistrano. Testing schedule is Mon and Wed. Reports are available within 4-14 days from the time the specimen is received at the send out testing lab. Test results may take up to 16 business days.
This test uses liquid chromatography/mass spectrometry to accurately measure free estradiol, the portion of estradiol that is not bound by SHBG. NOTE: This test is a send out test to Quest's Nichols Institute San Juan Capistrano. Testing schedule is Mon and Wed. Reports are available within 4-14 days from the time the specimen is received at the send out testing lab
Note: Studies on the effect of free estradiol blood levels in men are lacking. Only one reference concludes that free estradiol, not total, maybe a better predictor of bone density in older men (J Bone Miner Res 2005;20:1334–1341.)
Some physicians are starting to use this test in men with low Sex Hormone Binding Globulin with symptoms of high estradiol.
For more information about estradiol, read our blog posts
Free Estradiol, Percent
Reference Ranges (%)
Adult Males 1.7 - 5.4
Adult Females 1.6 - 3.6
Free Estradiol, Serum
Reference Ranges (pg/mL)
Adult Males 0.2 - 1.5
Adult Females 0.6 - 7.1
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