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Estrogen in Men: Myths and Realities of High Estradiol In men, the liver, fat cells, and other cells aromatize testosterone to produce estradiol, which is a hormone that is more prevalent in women than in men. Estradiol is responsible for healthy bone density and cholesterol, but its role in men’s sex drive, body composition, and other variables is a source of great debate. It is crucial to understand that estrogen plays a significant role in male reproductive health, particularly in the processes of sperm production and maturation within the testes. Many men on testosterone replacement therapy (TRT) initially fear high estradiol levels since they fear it causes water retention and gynecomastia. However, it is important to note that fat cells play a significant role in the production of aromatase, which can lead to higher levels of estradiol in the body. Below, we will discuss why most men on TRT do not have to be overly concerned about the estradiol lab ranges that are ill-fitted for men on TRT, as the ranges of LabCorp and Quest were not derived from a dataset of men on TRT who usually have higher total testosterone blood levels. What is Estradiol and Why is it Important for Men's Health? Estradiol is a type of estrogen hormone that plays a crucial role in men’s health. Often referred to as a 'female sex hormone,' estradiol also plays a crucial role in male health. It helps regulate bone density, cognitive function, libido, and mood. However, high levels of estradiol in men can lead to negative effects like decreased muscle mass, increased body fat, and hormonal imbalances. Men’s liver, fat, and other cells aromatize testosterone to produce estradiol, a hormone that is more prevalent in women than in men. Estradiol is responsible for healthy bone density and cholesterol, but its role in men’s sex drive, body composition, and other variables is a source of great debate. Many men on testosterone replacement therapy (TRT) initially fear high levels of estradiol since they fear it causes water retention and gynecomastia. We will talk about why most men on TRT do not need to worry too much about the estradiol lab ranges that do not work well for them because LabCorp and Quest did not get their ranges from a group of men on TRT who usually have higher total testosterone blood levels. High levels of estradiol in men are associated with abdominal obesity and an increased risk of cardiovascular disease. What is High Estradiol?: Predicted Blood Levels in Young and Older Men on TRT Transcript of video below: There needs to be more clarity on the subject since LabCorp and Quest have very narrow, sensitive estradiol test ranges. Those estradiol test ranges were primarily derived from men not on testosterone replacement therapy. Men on TRT tend to have higher testosterone levels than men not on testosterone replacement. So, believe it or not, a paper published many years ago predicts estradiol and DHT levels in men given different doses of testosterone. This study examined what happens to blood levels of testosterone, estradiol, and DHT when injecting different testosterone doses in young and older men. This study was very nicely done at the Boston University School of Medicine by well-known testosterone researchers. Dr. Basin is one of them and has done excellent work for the last 30 years. Video: How to Predict High Estradiol in Men Testosterone is the precursor hormone for estradiol. The aromatization of testosterone in the liver, fat, and other cells, including the testes, results in estradiol, a hormone that is more prevalent in women than men. Nature created it for a reason. It is responsible for healthy bone density and cholesterol, but its role in men's sex drive, body composition, and other variables is a source of great debate. Many anti-aging or men's health clinics prescribe aromatase inhibitors (AIs) to men who start testosterone replacement therapy (TRT). Higher estradiol blood levels in the presence of low testosterone can cause breast tissue growth (gynecomastia) in some men and possibly other issues. Some people speculate that high estradiol levels can also lead to difficulty achieving or maintaining an erection, but no scientific papers have been published on this subject. Since higher testosterone blood levels can result in higher estradiol levels in men, the belief is that using an AI will prevent breast tissue growth and erectile dysfunction by lowering any potential increase in estradiol. However, we have no data on how high is too high when it comes to this hormone in men using testosterone therapy. Emerging data show that low testosterone-to-estradiol ratios may correlate more closely to infertility, gynecomastia, and erectile problems than high estradiol levels alone. The truth about these speculations is starting to emerge, but we still need more data to say what the upper value of the optimal range of estradiol in men is. We have a lot of evidence about the lower side of the optimal range since it has been found that estradiol blood levels below 10–20 pg/mL can increase bone loss in men. A recently published study also nicely demonstrated that low estradiol could be associated with higher fat mass and lower sexual function in men. So, be careful when a clinic wants to put you on an aromatase inhibitor without first justifying its use. Increased Aromatase Activity and the Role of Aromatase Inhibitors in Men Aromatase is an enzyme that converts testosterone to estradiol, a form of estrogen. Germ cells, along with Leydig cells, are significant sources of estrogen production in the testes. In men, aromatase activity is typically low, but certain conditions can increase it, a process known as aromatase overexpression. This can lead to higher levels of estradiol in the body, which can have negative effects like decreased libido and muscle mass in the adult male. However, some studies suggest that moderate increases in estradiol may have cardiovascular benefits. One condition that can increase aromatase activity and therefore estradiol levels is aromatase excess syndrome, a genetic condition that affects both males and females. It’s important for men to maintain healthy levels of both testosterone and estradiol, and understanding the role of the aromatase enzyme, especially in conditions like aromatase excess syndrome, is crucial in managing estradiol levels. Estradiol in Men After Different Testosterone Doses: Study Details This study's findings were published in the Journal of Clinical Endocrinology and Metabolism in 2010. The fantastic thing is that nobody has reviewed it, even though it's probably the most important paper on what happens to estradiol and DHT in men on TRT. The study enrolled 51 young men aged 19 to 35 and 52 older men aged 59 to 75. These men were given a gonadotropin-releasing hormone agonist to shut down their gonadotropins, LH and FSH, testosterone, estradiol, and DHT. So, these were courageous volunteers who were willing to have their hormones wholly shut down. So, why did they do this? They did it because the researcher wanted to start from zero regarding hormones. So, those men were given injections of different doses of testosterone enanthate, 25, 50, 125, 300, and up to 600 milligrams a week for five months. And the researchers measured the testosterone, estradiol, and DHT blood levels. Unfortunately, they used the old estradiol test based on immunoassay. This estradiol test may not be the best for accurate estradiol testing. The use of an ultra-sensitive estradiol test is more accurate since it has no interference from CRP or inflammatory markers Usually, the sensitive estradiol is 20% lower than the estradiol levels measured by the old test. Let's assume that most of these men did not have inflammation. Here are their baseline characteristics. Interestingly, they were even exposed to such high doses of testosterone. So, after a four-week controlled period, they were given a testosterone blocker, the gonadotropin-releasing hormone agonist that shuts down gonadotropins. This drug is used to treat prostate cancer. They were randomized to receive weekly injections of testosterone enanthate for 20 weeks. The researchers found an issue with the higher testosterone dose in older men, with a few more side effects. They stopped a few men from continuing with the 600 milligrams of testosterone weekly. And then the randomization was limited to 25, 50, 125, and 300 milligrams of testosterone injections weekly. I've warned people not to use high testosterone doses, especially older people with comorbidities and heart problems. Increased blood pressure and tachycardia are some of the side effects listed in the study paper. So, what you see here are serum estradiol E2:T ratios. We talk about ratios on ExcelMale.com. Here are the opposite DHT and T ratios from what I typically talk about when dividing T by E2. And the black bars are younger men, and the white bars are older men. So, this is total estradiol, free estradiol, total DHT, and free DHT. And when we talk about free, what does that mean? It is the unbound estradiol and unbound DHT that aren't bound by sex hormone-binding globulin. And those two free estradiol and free DHT tests are rarely tested in clinics. DiscountedLabs.com does provide a free estradiol test for those who are interested. But since there are no studies about free estradiol blood levels in men, it's hard to say what a good free estradiol level is. High Estradiol in Men on TRT Most men on TRT initially fear high estradiol since they fear it causes water retention and gynecomastia. While high estradiol levels in men can cause gynecomastia, in women, similar hormonal imbalances are linked to an increased risk of breast cancer. They feel puffy; they may have more sensitive nipples. I will discuss this in another video because those symptoms are usually not connected to high estradiol per se when men have moderate to high testosterone levels. The most common cause of edema, or the problem of holding onto water weight, is a slowdown in sodium metabolism in the kidneys brought on by testosterone and androgens. Sodium (salt) retention happens in the first few weeks, especially with higher TRT doses in older men. The stimulating effects of testosterone may be to blame for the sensitive nipple issue, which typically does not cause gynecomastia. However, it is important to note that symptoms of high estrogen in men can also include swelling or enlargement of breast tissue, erectile dysfunction, infertility, depression, and delayed puberty. So, as you can tell, total E2, free E estradiol, and DHT increase with increasing testosterone doses, and this increase is much more pronounced in older men. It’s good to mention that these volunteers were not fat men. The increased fat mass has been linked to increased estradiol levels, which are often measured through body mass index (BMI). These are men with a BMI of around 26, which is not a high number. But anyway, we do see an increase. And older men, in white, tend to have a higher estradiol increase. DHT is the same thing. Although the differences were not as noted between young and old, you can tell here the free DHT. When you divide estradiol into testosterone, that’s when you see a decrease. Estradiol increases to a higher degree than testosterone, so the ratio of E2 divided by T decreases. The total DHT to T ratio is the same; it decreases as we increase the testosterone dose, but not as fast as the estradiol. It is essential to mention that 0.3% to 0.4% of testosterone is aromatized into estradiol. That’s a very tiny amount; that’s 0.4%. The conversion of testosterone to DHT by 5 alpha-reductase is around 10%. That’s why you see the scales a little more prominent on the DHT side. What to Know About Estrogen in Men Estrogen is commonly associated with women, but men also have this hormone in their bodies. The testes and adrenal glands are primarily responsible for producing estrogen in a male body. Estradiol is a type of estrogen that plays an important role in maintaining bone health, regulating cholesterol levels, and supporting brain function. Low levels of estradiol in men can contribute to a variety of health issues, such as decreased libido, erectile dysfunction, and osteoporosis. It's important for men to understand their hormonal balance, including their levels of estradiol, and work with a healthcare provider to address any imbalances or concerns related to erectile function and hormone balance. Buy an affordable, ultrasensitive estradiol test:   Understanding Androgens and Estrogens Estradiol is a type of estrogen that is found in both men and women. While it is often associated with female reproductive health, estradiol plays an important role in male health as well. Estrogens influence male reproductive function by maintaining a hormonal balance between estrogens and androgens, which is crucial for male fertility. In fact, it is responsible for regulating bone density, cholesterol levels, and even mood. When there is high estradiol in men, it can lead to a variety of health problems. Understanding the balance between androgens (male hormones) and estrogens (female hormones) is crucial for sexual development and maintaining optimal health for both men and women, especially in relation to the menstrual cycle. Risk Factors of Having High Estradiol in Men Estrogen is often associated with females, but it also plays a crucial role in men's health. High or low levels of estrogen in males can have negative impacts on their overall health. Men who have higher than normal levels of estrogen, also known as estrogen, may experience breast enlargement, erectile dysfunction, infertility, and other issues. On the other hand, men with lower than normal levels of estrogen may experience decreased bone density, muscle mass, and sex drive. It is important for men to maintain balanced estrogen levels through proper diet, exercise, and medical treatment if necessary. However, it is important to note that too much estrogen, also known as high levels of estrogen, can also be harmful to men's health, and it is important for individuals to monitor their estrogen levels and consult with a doctor if they have any concerns. How Men Can Keep Their Estrogen Levels Balanced Estrogen is typically associated with women, but men also have this hormone in their bodies. Estradiol is the most potent form of estrogen in men and plays a crucial role in maintaining bone density, sperm production, and sexual function. However, too much or too little estradiol can cause various health problems. Men can keep their estrogen levels balanced by maintaining a healthy weight, avoiding exposure to environmental toxins, managing stress levels, and getting enough sleep. A balanced diet rich in fiber and phytoestrogens, along with proper monitoring and control through hormone replacement therapy, may also help regulate estrogen levels in men, ensuring healthy sperm production. Normal Estrogen Levels in Men Estrogen is often thought of as a female hormone. However, it's also present in men, just at lower levels. One type of estrogen found in men is estradiol. Normal levels of estradiol in men vary depending on age and other factors. In general, levels range from 10 to 60 pg/mL. If levels are too high or too low, it can lead to health issues such as osteoporosis, sexual dysfunction, and mood changes. Men should discuss their estrogen levels with their healthcare provider to ensure they are within a healthy range for their age and overall health status. This includes monitoring the amount of estrogen in their body, as there are two main types of estrogen in men: estrone and estradiol, and an imbalance of these hormones can have negative effects on their health. Gynecomastia and High Estradiol in Men Gynecomastia is a condition that causes men to develop breast tissue. Studies on male mice, such as αERKO and ArKO models, highlight the effects of estrogen deficiencies on sexual behavior and fertility. One of the underlying causes of gynecomastia is an imbalance of hormones, including estradiol. Estradiol is a form of estrogen that is typically found at higher levels in women. However, men also have small amounts of estradiol in their bodies. When the balance between estradiol and testosterone is disrupted, it can lead to the development of breast tissue in men. Treatment for gynecomastia may involve addressing the hormonal imbalance through medication or surgery, depending on the severity of the condition. You can buy a gynecomastia lab test panel on Discounted Labs. Low Estradiol Can Cause Loss of Libido and Erectile Dysfunction One of the significant impacts of estradiol deficiency in men is the loss of libido. Low levels of estradiol can lead to decreased sex drive, which can cause problems in relationships and affect overall quality of life. However, it's essential to note that there are other factors that can impact libido as well, such as stress, depression, low testosterone levels, and a lack of sexual activity. If you're experiencing a loss of libido, it's important to talk to your doctor to determine the underlying cause and discuss possible treatment options. A Study Helps to Predict Normal Estradiol and DHT Test Levels in Men on TRT Most men on TRT don't have to be so concerned about the LabCorp or Quest estradiol ranges that usually scare people because they're always high. And there is statistical significance in the baseline values of young and older men. DHT increases were higher in older men. In younger men, usually, that's also connected to total testosterone and is also related to higher libido. Older men had lower DHT, which was also linked to their lower testosterone. Sex hormone-binding globulin (SHBG) is also higher in older men. The researchers in this study came up with a model with factors to predict the estradiol and DHT response curves. They provided two equations for young men (estradiol and DHT) and two for older men. Using those equations, you can roughly estimate the predicted estradiol and DHT levels for different testosterone blood levels. These equations enable us to see what is considered a “normal” estradiol level instead of using estradiol lab ranges that are ill-fitted for men on TRT. As previously mentioned, the estradiol ranges of LabCorp and Quest were not derived from a dataset of men on TRT who usually have total testosterone blood levels over 600 ng/dL (many men on TRT have T levels of 1000 ng/dL or more!). The Importance of Preserving Proper Levels of Estradiol in Men Our bodies transform 0.4% of testosterone into estradiol to balance the potentially negative effects of testosterone alone on lipids and other variables. If you have “high” testosterone, your estradiol should be “high.” Treating that estradiol with an aromatase inhibitor may not be needed and can potentially crash your estradiol level. Estradiol has essential roles in men, including the regulation of hormone levels. Estradiol comes in to protect us from higher testosterone and helps improve lipids, HDL, and endothelial function. Women tend to live longer than men because they have more estrogen to protect them against the cardiovascular risks we are all exposed to. So, don't freak out when you see the 60s, even in the 70s, depending on how high your testosterone is. And the only problem we're having in this field is that we still need to do a study that goes after symptomology depending on estradiol blood levels when we control testosterone. We know that estradiol levels under 15 picograms per milliliter cause problems with bone density and even fat gain. Many members of ExcelMale.com say that their penile sensitivity decreases when they have low estradiol. We do not know what high estradiol in men means in relation to estradiol blood levels in relation to testosterone. Can high estradiol in men on TRT with relatively high testosterone blood levels cause issues? Is there a proper and healthy testosterone-to-estradiol ratio?. If somebody is, let's say, at 1,275 ng/dL of testosterone and 64 pg/mL of estradiol, is there any consequence to that? We don't know. And the problem I'm seeing is that most of you guys are assuming too much; you're assuming that because you're holding water or you have sensitive nipples, you have high estradiol. And you start treating with an AI without even testing your blood levels of estradiol, especially using the sensitive assay. That concerns me because once you start treating with an AI, you can crash your estradiol. “Crashed estradiol” has become one of the most significant traffic source keywords for ExcelMale because people are experiencing that more and more. I hope you enjoyed the presentation. Please remember to subscribe to the ExcelMale forum and the ExcelMale YouTube channel, and make sure that you click on that little bell that will tell you when I upload new videos. Thanks a lot, and stay safe. Estrogen Dominance and Hormonal Imbalance Estrogen dominance occurs when there is an imbalance between estrogen and testosterone levels in the body. This hormonal imbalance can lead to a range of symptoms, including weight gain, mood swings, and decreased libido. Men experiencing estrogen dominance may notice an increase in body fat, particularly around the abdomen, and may struggle with emotional changes such as irritability or depression. Additionally, estrogen dominance can negatively impact overall health by contributing to conditions like insulin resistance and cardiovascular issues. Maintaining a proper balance between estrogen and testosterone is crucial for optimal health and well-being. Exposure to Endocrine Disruptors and Environmental Toxins Endocrine disruptors and environmental toxins can significantly impact estrogen levels and overall health. These substances, found in everyday items like plastics, pesticides, and personal care products, can mimic the effects of estrogen in the body, leading to hormonal imbalances. When these toxins enter the body, they can bind to estrogen receptors, disrupting the natural hormonal balance and potentially causing a range of health problems. It’s essential to be aware of these environmental toxins and take steps to minimize exposure, such as choosing organic foods, using natural personal care products, and avoiding plastic containers. Other Non-Reproductive Effects of High Estrogen High estrogen levels can have a range of non-reproductive effects on the body, impacting various aspects of health and well-being. Some of the common non-reproductive effects include: Weight gain and obesity: Elevated estrogen levels can lead to increased body fat, particularly around the abdomen, contributing to obesity. Mood swings and emotional changes: High estrogen can cause mood swings, irritability, and even depression. Fatigue and low energy: Men with high estrogen levels may experience chronic fatigue and a general lack of energy. Insomnia and sleep disturbances: Hormonal imbalances can disrupt sleep patterns, leading to insomnia and poor sleep quality. Skin problems: High estrogen levels can cause skin issues such as acne and rosacea, affecting overall skin health. Maintaining balanced estrogen levels is essential for overall health and well-being, and addressing any hormonal imbalances can help alleviate these symptoms. Foods that Lower Estrogen: Cruciferous Vegetables and Sulforaphane Cruciferous vegetables, such as broccoli, cauliflower, and Brussels sprouts, are known for their ability to help lower estrogen levels in the body. These vegetables contain a compound called sulforaphane, which has been shown to support the detoxification of excess estrogen. Incorporating cruciferous vegetables into your diet can help maintain healthy estrogen levels and support overall hormonal balance. Additionally, these vegetables are rich in fiber and other essential nutrients, making them a valuable addition to a healthy diet. By including more cruciferous vegetables in your meals, you can naturally help regulate estrogen levels and promote better health. Buy an affordable, ultrasensitive estradiol test:   I hope you enjoyed the presentation. Please remember to subscribe to the ExcelMale forum and the ExcelMale YouTube channel, and make sure that you click on that little bell that will tell you when I upload new videos. Thanks a lot, and stay safe. More information about high estradiol in men Citations Understanding Blood Test Results: Estradiol (Male) Aromatase Inhibitors in Men: Mechanisms and Benefits Aromatase Inhibitors: No More, No Less Estrogen in Men: Understanding Its Role and Effects The Role of Estradiol in Male Reproductive Health Effects of Estrogen on Men's Health Estrogen in Men: What You Need to Know Estrogen's Impact on Men's Health: A Scientific Study When to Take Anastrozole with Testosterone Estrogen and Male Health: Research Findings The Role of Estrogen in Men's Health When to Use Aromatase Inhibitor with TRT What Causes High Estradiol Levels in Males?  

Accurate estradiol testing is of great importance for both genders in order to preserve optimal health, well-being, and physical condition. Estradiol, a type of estrogen hormone essential for reproductive health and various physiological processes, must be accurately measured to ensure optimal health. Measuring estradiol levels with precision can help identify low or high levels that may be associated with various medical conditions. In this blog post, we will delve into the importance of accurate estradiol testing in males and discuss the limitations of immunoassay-based tests - including their inaccuracy at lower concentration ranges and potential interference from C-reactive protein (CRP). We will then explore the advantages of sensitive LC/MS estradiol tests for males, such as improved sensitivity and specificity along with reduced influence from CRP or associated factors. Furthermore, we'll examine a study comparing immunoassay and mass spectrometry measurements while highlighting its implications on inflammation-related outcomes. Finally, we'll touch upon how accurate estradiol testing impacts hormone management strategies and testosterone replacement therapy monitoring. Table of Contents: Importance of Accurate Estradiol Testing in Males The Role of Estradiol in Men's Health Why Traditional Estradiol Tests May Not Be Sufficient for Men Limitations of Immunoassay-Based Estradiol Tests Inaccuracy at Lower Concentration Ranges Potential Interference from C-Reactive Protein (CRP) Advantages of Sensitive LC/MS Estradiol Test for Males Improved Sensitivity and Specificity Reduced Influence from CRP or Associated Factors Study Comparing Immunoassay and Mass Spectrometry Measurements Moderate Correlation Between Testing Methods Influence on Inflammation-Related Outcomes Implications for Hormone Management and Testosterone Replacement Therapy Monitoring Frequently Asked Questions Accurate Estradiol Testing What is the most accurate way to test estrogen levels? Are estrogen tests accurate? Can estradiol test wrong? What is the best estradiol test? What day is best to test estradiol? Conclusion Importance of Accurate Estradiol Testing in Males Measuring estradiol levels accurately is crucial for men's health, as low estradiol can negatively impact bone health, sex drive, and may lead to fat gain. It is essential for physicians not to overdiagnose high estradiol due to using an inaccurate test. In recent years, the importance of accurate estradiol testing has become more apparent with increasing awareness about its role in various aspects of male reproductive health. The Role of Estradiol in Men's Health Bone Health: Low estradiol levels have been linked to a higher risk of osteoporosis and fractures in men. Maintaining optimal serum estradiol levels helps preserve bone mineral density and prevent age-related bone loss. Sex Drive: Although testosterone plays a significant role in regulating libido, adequate estradiol concentrations are also necessary for maintaining healthy sexual function. Fat Gain: Studies have shown that low estrogen levels can contribute to increased abdominal fat accumulation and reduced insulin sensitivity in males. To ensure proper diagnosis and treatment strategies for patients experiencing symptoms related to imbalanced hormones like estrogen (estradiol), healthcare professionals must use the most accurate methods available when measuring these critical biomarkers. One such method gaining popularity among practitioners is the sensitive liquid chromatography-tandem mass spectrometry (LC/MS) assay - a highly precise technique capable of detecting even minute amounts present within blood samples taken from individuals being assessed during routine checkups or follow-up visits following initiation onto hormone replacement therapy regimens (source). Why Traditional Estradiol Tests May Not Be Sufficient for Men Immunoassays like ECLIA (Electrochemiluminescence Immunoassay) are frequently used to measure female estradiol levels. However, these tests may not be suitable for accurately determining low estradiol levels typically found in men due to their limited sensitivity and specificity at lower concentration ranges. Inaccurate test results can lead physicians to misdiagnose patients with high or low estradiol concentrations, potentially resulting in unnecessary treatments or interventions that could further exacerbate existing health issues rather than alleviate them. As a result, it becomes increasingly important for healthcare providers working within this field - particularly those specializing specifically within male reproductive medicine - adopt more advanced testing methodologies capable of providing accurate assessments regardless of whether someone has too much/too little circulating throughout their system (source). Immunoassay-based estradiol tests should be employed with caution, as their accuracy can be compromised by various factors. Understanding these limitations is critical for ensuring reliable results in male health monitoring. By better understanding potential interference from C-reactive protein (CRP) as well as the inaccuracy at lower concentration ranges, we can better assess our risk factors and make informed decisions about our health.   Key Takeaway:  Discounted Labs offers low-cost lab tests without a doctor's visit in many U.S. cities, and the topic of accurate estradiol testing is being discussed. Limitations of Immunoassay-Based Estradiol Tests Traditional immunoassay-based techniques, such as ECLIA (Electrochemiluminescence Immunoassay), have been widely used for measuring estradiol levels in the past. Immunoassay-based techniques, like ECLIA, are not as precise when detecting estradiol levels at lower concentrations that are more common in men. This can lead to misleading results and incorrect diagnoses or treatment plans. Inaccuracy at Lower Concentration Ranges Immunoassays perform best at higher concentrations suitable for adult females but struggle with precision and accuracy at the lower ranges commonly seen in males. As a result, they may overestimate or underestimate estradiol levels in men due to their limited sensitivity within this range (source). Consequently, healthcare professionals relying on these tests might not be able to make informed decisions about hormone management or monitoring testosterone replacement therapy. Potential Interference from C-Reactive Protein (CRP) Besides being inaccurate at lower concentration ranges, immunoassays can also be influenced by other factors present in blood samples that could interfere with test results. One such factor is C-reactive protein (CRP), an inflammation marker associated with various health conditions like obesity and cardiovascular disease. Interference: CRP has been shown to bind non-specifically with antibodies used in some immunoassays, leading to falsely elevated estradiol levels in men (source). Inflammation-related outcomes: Previous association studies between immunoassay E2 levels and inflammation-related outcomes might need reevaluation due to this potential interference. In light of these limitations, it becomes essential for healthcare professionals conducting hormone assessments on their patients' behalf - especially if they're trying accurately determine whether someone has too much or too little circulating throughout their system - opt instead for highly precise LC/MS technology rather than relying solely upon outdated methods employed previously via standard assays alone so as to ensure optimal results every time without fail. C-reactive protein (CRP) may have an impact on immunoassay-based estradiol tests, which can be inaccurate at lower concentration ranges. However, a more sensitive LC/MS test offers improved accuracy with reduced interference from CRP or associated factors.   Key Takeaway:  Discounted Labs offers lab tests without a doctor's visit in most U.S. cities, and the topic of accurate estradiol testing is being discussed. Advantages of Sensitive LC/MS Estradiol Test for Males The LC/MS assay offers greater sensitivity and specificity than traditional immunoassay-based techniques, such as ECLIA, for measuring estradiol levels in men at the lower concentrations typically found. These benefits include better sensitivity and accuracy at the lower concentrations of estradiol typically found in males, ensuring precise measurements without potential interference from other factors. Improved Sensitivity and Specificity One significant advantage of using the sensitive LC/MS estradiol test is its ability to accurately measure lower concentrations of this hormone. This is particularly important for men since their normal range falls within these low concentration levels. Healthcare professionals are better equipped to make decisions about potential treatments or lifestyle adjustments when they have access to more precise measurements. Reduced Influence from CRP or Associated Factors A study published in The Journal of Clinical Endocrinology & Metabolism revealed that immunoassay-based tests could be influenced by C-reactive protein (CRP) or associated factors, which might cause interference during analysis. The sensitive LC/MS assay significantly lessens this influence, allowing for more accurate results that are independent of outside factors. In addition to these advantages, the use of sensitive LC/MS technology ensures consistent results across different laboratories and testing facilities due to its standardized methodology. As a result, patients and healthcare providers can trust the accuracy and reliability provided by this advanced method of estradiol testing. The advantages of the sensitive LC/MS estradiol test for males are clear: improved sensitivity and specificity, as well as reduced influence from CRP or associated factors. It is critical to assess how these tests stack up when measuring inflammation-related results by looking into a comparison between immunoassay and mass spectrometry evaluations. "Get accurate and reliable estradiol testing with the sensitive LC/MS assay. Say goodbye to potential interference from external factors. #healthcare #hormonalimbalance" Click to Tweet Study Comparing Immunoassay and Mass Spectrometry Measurements A study published in The Journal of Clinical Endocrinology & Metabolism aimed to compare the accuracy of immunoassay-based estradiol tests with mass spectrometry measurements among middle-aged and older male subjects participating in various population-based studies. This comparison was essential for understanding the limitations of traditional methods like ECLIA when measuring serum estradiol levels, particularly in men. Moderate Correlation Between Testing Methods The study found that, within each cohort, serum E2 levels obtained by immunoassay correlated moderately with those measured by mass spectrometry (MS). However, this moderate correlation does not guarantee equal accuracy between the two methods, especially when measuring low estradiol levels typically found in men, which may influence inflammation-related outcomes. Instead, it highlights a potential discrepancy when using immunoassays for measuring low estradiol levels typically found in men. Influence on Inflammation-Related Outcomes The researchers uncovered a potential issue when utilizing immunoassays to gauge low estradiol concentrations normally found in men - the measurements were affected by C-reactive protein (CRP) or CRP-related components, potentially interfering with analysis. This means that previous association studies between immunoassay E2 levels and inflammation-related outcomes might need reevaluation due to this potential interference. This discovery further emphasizes the importance of using sensitive liquid chromatography-tandem mass spectrometry (LC/MS)-based assays for accurate measurement of serum estradiol levels in males. By opting for LC/MS technology over outdated methods like standard assays alone, healthcare professionals can ensure optimal results without fail while monitoring hormone management or testosterone replacement therapy among their patients experiencing issues like fatigue or erectile dysfunction resulting from imbalanced hormones like estrogen (estradiol). This research has revealed a moderate association between immunoassay and mass spectrometry measurements, with potential ramifications for inflammatory effects. Moving on to the next heading, we will explore how these findings can be used to improve hormone management and testosterone replacement therapy monitoring. "Accurate estradiol testing is crucial for hormone management. A study shows LC/MS-based assays provide optimal results compared to outdated immunoassay methods." #hormonemanagement #estradioltesting Click to Tweet Implications for Hormone Management and Testosterone Replacement Therapy Monitoring Accurate estradiol testing plays a significant role in hormone management and testosterone replacement therapy (TRT) monitoring. Men enduring signs such as exhaustion, low libido, or impotence may reap rewards from TRT to restore hormone balance. However, it is crucial to monitor estradiol levels alongside testosterone levels during treatment to ensure optimal results. The sensitive LC/MS-based estradiol test for males offered by DiscountedLabs.com provides several advantages over traditional immunoassay tests: Better sensitivity and specificity: The LC/MS method accurately measures lower concentrations of estradiol typically found in men, ensuring precise evaluation of hormonal imbalances. No interference from CRP or associated factors: Unlike immunoassays that can be influenced by C-reactive protein (CRP), the LC/MS assay eliminates potential interferences for more reliable results. Incorporating accurate estradiol testing into hormone management strategies helps healthcare professionals make informed decisions regarding treatment plans. To ensure proper hormone balance, physicians may adjust TRT dosage or prescribe an aromatase inhibitor if a patient's estrogen levels are too high. To learn more about how accurate estradiol testing can improve your health journey and support effective hormone management practices, visit our blog post demonstrating its importance among men seeking optimal hormonal balance. "Optimize your hormone management with accurate estradiol testing from Discounted Labs. Ensure precise evaluation of hormonal imbalances for optimal results. #HormoneManagement #TRT" Click to Tweet Frequently Asked Questions Accurate Estradiol Testing What is the most accurate way to test estrogen levels? The most accurate method for testing estrogen levels, specifically estradiol, is liquid chromatography-tandem mass spectrometry (LC/MS). This technique offers improved sensitivity and specificity compared to immunoassay-based tests. Studies have shown that LC/MS provides more reliable results in both males and females. Are estrogen tests accurate? Estrogen tests can be accurate, depending on the method used. At lower concentration ranges, immunoassay-based tests are less reliable and may be subject to interference from C-reactive protein (CRP). However, sensitive LC/MS methods offer greater accuracy due to their enhanced sensitivity and reduced influence from CRP or associated factors. Can estradiol test wrong? Estradiol tests can sometimes produce inaccurate results if using an immunoassay-based method, especially in males with low concentrations of estradiol. The presence of CRP or other interfering substances may also affect the accuracy of these tests. Opting for a sensitive LC/MS test reduces the likelihood of erroneous results. What is the best estradiol test? The best estradiol test is one that uses liquid chromatography-tandem mass spectrometry (LC/MS), as it offers superior sensitivity and specificity compared to traditional immunoassays. This makes it particularly suitable for accurately measuring low concentrations of estradiol in males undergoing hormone management or testosterone replacement therapy monitoring. What day is best to test estradiol? For women, the best day to test estradiol depends on their menstrual cycle. In general, it is recommended to test estradiol levels during the follicular phase of the cycle (days 2-4). For men and postmenopausal women, there are no specific days for testing; however, consistency in timing can help monitor changes over time. Conclusion Accurate estradiol testing is essential for monitoring hormone management and testosterone replacement therapy in males. The results of a recent study comparing immunoassay-based tests to LC/MS measurements demonstrate that the latter are far more sensitive, reliable, and accurate. Therefore, it is recommended that all men undergoing hormone management or testosterone replacement therapy use an LC/MS test when checking their estradiol levels. Accurate data is essential to enable informed decisions regarding medical care, so LC/MS testing should be employed when evaluating estradiol levels in men undergoing hormone therapy or testosterone replacement. Take control of your health today and get an accurate estradiol test from Discounted Labs. With our convenient, affordable services, you can easily access lab tests without the need for a doctor's visit.  

Key Highlights Understand the importance of sensitive estradiol testing for hormone therapy and men's health. Learn about the benefits of choosing discounted labs for your estradiol sensitive test. Discover the differences between standard and sensitive estradiol tests, including the testing methodologies involved. Prepare effectively for your estradiol sensitive test by following specific guidelines. Get insights into interpreting and understanding your estradiol test results with the help of healthcare providers. Explore the convenience of ordering your estradiol sensitive test online and what to expect during the process. Introduction Estradiol is an important hormone for both men and women. It affects many parts of our health. It plays a significant role in maintaining bone health, cognitive functions, sex drive, and overall body composition in both genders. It is especially important to understand estradiol in men's health. There are many myths about estradiol in men. This makes it essential to have accurate testing. Choosing a sensitive estradiol test can give clear information about hormonal levels. This allows for quick action if needed. This blog looks at the benefits of discounted labs for these tests. It also helps you know how to order and prepare for a sensitive estradiol test. Understanding Estradiol and Its Importance for Men Estradiol plays an important role in men's health. As the hormone responsible for developing and regulating the male reproductive system, it affects many body functions, including bone strength, sex drive, and mood. Understanding estradiol is crucial because imbalances in levels can lead to issues such as weaker bones, changes in sex drive, and hormone imbalances. That's why it is important to regularly check estradiol levels through tests to identify any potential concerns that may require medical attention. The Role of Estradiol in Male Health Estradiol is very important for men’s health, even though it is mostly known as a hormone for women. In men, estradiol helps keep bones strong, manage sexual desire, and support heart health. It also plays a key role in mood, thinking, and making proteins. Moreover, estradiol helps control the production of testosterone. If the levels of estradiol are not right, it can cause health problems. This shows how important it is to know about and check this hormone in men's health. Common Misconceptions About Estradiol in Men Estradiol is important for men's health, not just a hormone for women. Men can also experience problems with estradiol levels, which can affect their well-being. One common myth is that all types of estrogen are bad for men. In fact, having the right amount is key for good health. Another myth is that high estradiol always causes harm. Both low and high levels can negatively impact men's health. Knowing the truth about these myths can help people make better choices for their health care. Why Opt for a Sensitive Estradiol Test? Find out important hormonal imbalances with a sensitive estradiol test. This test gives specific results that normal tests may overlook. It helps in making accurate health evaluations. Differences Between Standard and Sensitive Estradiol Tests Standard estradiol tests check a wide range of estradiol levels in the blood. This gives a general view of hormone levels. On the other hand, sensitive estradiol tests use advanced methods like liquid chromatography and mass spectrometry, also known as immunoassay estradiol test. These methods help find low levels of estradiol with more accuracy, making it a highly sensitive estradiol test. The LC-MS estradiol test is primarily suggested for situations with very low estrogen levels. The sensitive test is better for people who need careful hormonal analysis. While standard tests can work well in many cases, sensitive tests give more detailed information. This is especially true for those with mild hormone imbalances. Choosing the right test depends on how much detail you need about estradiol levels. Identifying Symptoms of Estradiol Imbalance Estradiol imbalances can show different symptoms. In men, low estradiol levels may cause a lower sex drive and tiredness. High estradiol levels can result in male feminization. Both men and women may have dry skin and hormonal changes. Due to changes in estradiol levels, which birth control pills can also affect, women may experience irregular menstrual cycles or fertility issues. It's important to notice these signs and get estradiol testing to fix any imbalances quickly. Symptoms are key indicators showing the need to check for possible estradiol imbalances. Stay aware of these signs to keep good health. The Benefits of Using Discounted Labs for Buying Your Estradiol Sensitive Test Online Discounted labs provide a cheap way to get your estradiol test without losing quality. They have lab locations all over the country, making it easy for you to access their services. By using discounted labs, you save money while getting accurate test results. This is a great option for people looking for affordable healthcare. These labs give you a wallet-friendly choice without lowering the dependability and accuracy of your test results. Using discounted labs can help you monitor your estradiol levels easily and conveniently. Affordability Without Compromising Quality Discounted labs provide lowest cost estradiol sensitive teststhat are still high quality. These affordable options help you take care of your health without spending too much money. When you choose discounted labs, you get reliable results while saving cash. Being affordable does not mean you lose accuracy or dependability. These labs follow strict quality rules to give you trustworthy results that you can rely on. Caring for your health should not cost a lot, and discounted labs make great testing cheap and easy to get. You can pick affordable options without losing quality in your healthcare experience. Nationwide Lab Locations for Your Convenience Find it easy to access lab locations for your sensitive estradiol test. You can place a simple order online and choose the testing laboratory near you. There is a large network of collection sites to make your testing process smooth and quick. You will enjoy the ease of getting your blood sample taken at a place that works best for you. This saves you time and effort. Whether you’re in a busy city or a small town, you can find the closest lab location for your estradiol test at our nationwide reference lab locations without any trouble. How to Order Your Estradiol Sensitive Test Online To get your Estradiol Sensitive Test online, go to Discounted Labs's Sensitive Estradiol product page. Find the test in the menu and add it to your shopping cart. Next, go to checkout and fill out the information needed. After you place your order, you will get a confirmation email with instructions on how to download your lab request. Then, relax while the lab processes your lab request and gets ready for your test. It’s easy to take control of your health with just a few clicks. Simple Steps to Secure Your Test To get started, go to our website and pick the "Estradiol Sensitive Test" from our list of lab tests. Add the test to your shopping cart. Then, go to the checkout. Fill in the needed details and choose the closest lab location that works for you. After you pay, you will get a lab order to take with you to the lab. Don't worry, the process is easy and helps check your estradiol levels accurately through secure and reliable repeat testing. What to Expect After Placing Your Order When you order the sensitive estradiol test online, you will get a quick confirmation email about your purchase. Usually, the test kit will be sent to your address fast. Once you get it, follow the instructions it comes with to collect your sample. Then, send the sample back as directed for testing. Your results will be processed quickly, and you will receive them safely by email within the set time. You can feel confident that your experience with the sensitive estradiol test is simple and easy. Preparing for Your Estradiol Sensitive Test Prepare well for your Estradiol Sensitive Test by following these simple steps. First, talk to your healthcare provider for any special instructions. It is important to schedule this test during the follicular phase of your menstrual cycle and avoid taking any medication that might alter your estradiol levels during this time, such as birth control pills. Also, let the lab know if you are taking any medication that might change your estradiol levels. Make sure to arrive at the collection site well-hydrated. This will make the blood draw easier. By knowing these steps, you will get correct and trustworthy results from your test. Understanding the luteal phase of your menstrual cycle is also important in interpreting your estradiol levels, as they will naturally fluctuate during this time. Understanding Your Test Results Estradiol test results give important information about the hormone levels in your body, especially for individuals with conditions such as liver disease. This sensitive test provides detailed facts for your healthcare provider. Knowing the levels of estradiol is key because they can show if there are hormone imbalances or other health problems. These levels can also affect things like bone health, sex drive, and your overall well-being. Understanding these results can be complex, so it's important to talk to your healthcare provider. They can help you make sense of your estradiol test results. Conclusion Regularly checking estradiol levels is important for men's health. You can choose a sensitive estradiol test online to learn more about your hormone balance. Discounted labs provide easy and affordable options while still offering good quality. You can easily order your test online and prepare by following simple steps. Knowing your test results is key to spotting any hormone imbalance. Take control of your health today to keep your hormone levels at their best for your overall well-being and energy.   References The role of estradiol in male reproductive function Estradiol in Men- Myths and Realities Role of Estradiol (Estrogen) in Men and Its Management

Table of Contents Brain Aromatase and Why It’s Not a Good Idea to Reduce Its Activity Estrogen and its beneficial effects in bodybuilding Estrogen function in men and why inhibiting its production can be detrimental.  High estrogen levels and prostate cancer Testosterone’s conversion to estrogen is important to eliminate anxiety and depression Testosterone activity in the brain High estradiol levels are not correlated with erectile dysfunction Estradiol improve endothelial function in healthy men Estradiol and libido, erectile function and reproduction How estradiol works when testosterone levels are low Estradiol and its influence in eugonadal men (men with normal testosterone levels.) Analyzing the role of estradiol on hypogonadal men who undertake testosterone replacement therapy Aromatase inhibition can decrease insulin sensitivity The relationship between estrogen and bodybuilding Estradiol and DHT can make you age more slowly Symptoms of low estradiol in men Estradiol and reproductive function in men Brain Aromatase and Why It’s Not a Good Idea to Reduce Its Activity Every man has free and bound testosterone circulating through his bloodstream. The bound testosterone is attached to either sex hormone-binding globulin or albumin. The free testosterone is available in small quantities in comparison with the bound testosterone. A small portion of it is converted to estrogen using the enzyme called “aromatase”. Although estrogen is a female sex hormone, it plays an important role in a male’s body too. For example, estradiol, a type of estrogen, is vital for proper sexual functioning and libido in men. However, too much estrogen can be detrimental, leading to poor sexual functioning, poor erections, accumulation of fat in the abdominal area and male boobs (gynecomastia). During testosterone replacement therapy (TRT), some men take drugs to inhibit aromatase and prevent it to convert too much testosterone into estrogen. these drugs inhibit the aromatase enzyme. Although this might sound like a good idea at first, altering the normal production of aromatase can lead to brain inflammation, studies suggest. The levels of aromatase and estrogen have been measured in injured brains and it has been discovered that the aromatase enzyme increased to protect the damaged neurons and the connections between them. Evidence concludes that inhibiting the normal levels of aromatase can lead to inflammation in healthy brains and more injury to already damaged brains. This happens because the aromatase/estrogen expression is moved from neurons to astrocytes which are a different type of brain cells. Astrocytes act as a cushion for neurons and they are usually more active when brain injury is detected. These cells can help with the healing process, but if they stay active for too long, this can lead to further damage to the brain. Studies also show that an insufficient amount of brain aromatase can indicate neurodegenerative diseases such as Alzheimer's. Low amounts of aromatase can increase plaque development which damages the brain. That’s why it is recommended to be careful when taking an aromataseinhibitor during testosterone replacement therapy as this drug might mess with the normal levels of aromatase and lead to brain complications.   Estrogen and its beneficial effects in bodybuilding Estrogen, one of the most important female sex hormone, is vital for professional athletes who aim at increasing their muscle mass. For example, estrogen can increase the anabolic response by modifying the way glucose is processed in muscle tissue. This hormone can influence the amounts of glucose 6-phosphate dehydrogenase which is directly correlated to muscle growth and repair. In other words, having adequate amounts of estrogen can maximize muscle gains and strength. In studies performed on rats, estrogen has also been correlated with a whopping 480% increase in methyltrienolone which is an androgen connected to the levator ani muscle. The production of growth hormone and IGF-1 (insulin-like growth factor) are also influenced by estrogen. This female sex hormone can increase the proliferation of IGF-1 in body tissues and liver which leads to greater muscle gains and protein synthesis. Estrogen also plays an important role when it comes to serotonin production. Serotonin is known for regulating the sleep/waking cycle. Bodybuilders who take aromatase inhibitors as drugs might have low levels of estrogen in the body. This can alter the serotonin production and lead to a thing called “steroid fatigue”. This is usually characterized by a general feeling of tiredness which can interfere with training regimes and prevent the athlete from performing at his peak. Maximizing muscle gains can be difficult in this case. Estrogen function in men and why inhibiting its production can be detrimental.  The aforementioned aromatase inhibitors are taken orally while one of them can be injected. There haven’t been studies assessing the short-term symptoms of these drugs on the physiology of an athlete. However, although drugs which inhibit aromatase and subsequently reduce estrogen levels are not usually used for a long period of time, they can cause problems when the estrogen drops under the normal range limit. Estrogen, particularly estradiol, is a powerful hormone which influences multiple body processes in both men and women. For example, estrogen can be anabolic in certain tissues such as bone and fat. It directly impacts bone density and can influence how much fat the body accumulates, particularly in the abdominal area. Estrogen can also have a stimulatory role and it influences protein production in the liver. It has a metabolic effect in the endocrine system and influences the binding globulins for vitamin D. Estrogen is also a neurosteroid influencing neurotransmitters in the brain. This can have an effect on emotions, motivation, and other functions. Since estrogen is so important in the human body, it is safe to assume that reducing it to dangerously low levels using drugs can have negative consequences on health. Similarly, having estrogen levels above the normal limit can also be detrimental for a male’s body. The key is to maintain balance when it comes to estrogen levels and make sure that estradiol E2 doesn’t drop below 20pg/mL.   The effects of aromatase inhibition on bone mineral density in older men A study was conducted at a tertiary care academic center in Boston, MA, measuring the levels of testosterone and estradiol of 69 men over 60 years of age. The participants had borderline or low testosterone levels and the study included a placebo group. The purpose of the study was to determine the effect of aromatase inhibition on bone mineral density and bone turnover. Each participant received 1 mg of an aromatase inhibitor daily or a placebo drug. At the end of the study, the serum testosterone increased from 319 ± 93 ng/dl at baseline to 524 ± 139 ng/dl in month 3 and dropped slightly after one year. The estradiol levels also decreased from 15 at baseline to 12 after 3 months and remained there. The bone mineral density decreased in the aromatase inhibitor group in comparison with the placebo group. Taking aromatase inhibitors reduce the amount of testosterone which is converted to estradiol and because participants had less estradiol in their bloodstream, their bone mineral density also dropped. This concludes that estradiol is important for bone mineral density, particularly in older men. Is anastrazole for men a good idea?   High estrogen levels and prostate cancer Some studies conclude that high levels of estrogen might help develop prostate cancer cells, but men who already have prostate cancer don’t have high levels of estrogen in the bloodstream. Other studies show that a sharp increase in estrogen levels might lead to prostate cancer, but more information is required to reach a definitive conclusion. A small part of the free testosterone which circulates through the bloodstream is converted into estrogen. This hormone is required for maintaining proper health and avoiding cardiovascular diseases as well as diabetes type 2. On the other hand, low testosterone levels have also been associated with an increase in prostate cancer cells. A significant body of evidence indicates that high estrogen levels might be dangerous for men and affect their prostate only when testosterone levels are too low. Increasing testosterone levels through TRT (testosterone replacement therapy) will also increase estrogen levels in a natural way, but this doesn't automatically mean that the risk of prostate cancer will be higher. Approximately 50 years of studies show that testosterone administration alone doesn’t lead to prostate cancer.   Testosterone’s conversion to estrogen is important to eliminate anxiety and depression It is estimated that approximately 20 million adults in the United States are affected by depression each year. Many of these people receive antidepressants and anti-anxiety drugs, but this medicine can have different effects on certain people and they don’t come without side effects. Testosterone plays an important role in reducing anxiety and depression feelings in men, while estrogen and progesterone also act together as a protective mechanism against depression in women. Women, in particular, are 70 percent more predisposed to depression during their lifetimes, in comparison with men. However, certain low-testosterone males also develop depression and antidepressants seem to be inefficient for them. New evidence suggests that the conversion of testosterone to estrogen is necessary to reap the antidepressant effects of testosterone. Professor Mohamed Kabbaj reached this conclusion during his studies which were promoted by the National Institute of Mental Health. It has been discovered that there is a link between testosterone conversion to estrogen and depression in animal studies, but this link might be valid in human studies as well. This might lead to new antidepressants which impact the brain differently and are more efficient for low-testosterone men. Testosterone influences a plethora of pathways in the brain and it can have multiple side effects. That’s why it is important to develop a drug which acts only on the pathways responsible with anxiety and depression. Some of the side effects caused by antidepressants include heart problems and these should be avoided. Better drugs are necessary to impact the brain differently and safely treat anxiety and depression feelings. Dr. Kabbaj discovered that the antidepressant effects of testosterone happen only after this hormone has been converted to estrogen. The conversion process is regulated by a special enzyme in the brain. Dr. Kabbaj inhibited this enzyme in the hippocampus area of the brain. This area is responsible for mood regulation and has a strong influence on how a person feels. When this enzyme has been inhibited, the antidepressant effects of testosterone weren’t present. This leads to the conclusion that the conversion of testosterone to estrogen is very important. Testosterone impacts the MAPK pathway in the brain to produce these positive and beneficial antidepressant effects. However, this pathway is also implicated in multiple other body processes, including cell growth and cancer. More work is required to find out ways to get the antidepressant effects of testosterone without increasing the risk of cancer. Testosterone activity in the brain Tests have been done on rats to discover the behavior of testosterone when it enters the brain. Castrated rats have been injected with estradiol instead of testosterone and the recovery process of intromission and ejaculation worked normally. The estradiol was injected into the hypothalamus. However, when DHT was injected instead of testosterone (DHT is a powerful androgen which doesn’t convert to estrogen), no recovery process was detected. This concludes that testosterone converts to estrogen when it is injected into the hypothalamus and facilitates sexual behavior. The aromatase enzyme is present in this part of the brain as well as estrogen receptors. It has also been discovered that injecting drugs which block the aromatization process of testosterone to estrogen can change the behavioral effects of testosterone and significantly influence sexual function. This means that testosterone must convert to estrogen to enable proper male sexual behavior. Further studies show that inhibiting the aromatization process in monkeys can interfere with their sexual behavior. Men who have a congenital deficiency of aromatase also have a low sex drive and they can benefit greatly from small doses of estradiol to improve sexual functioning. The testosterone’s effects on male sexuality are twofold. This hormone influences libido directly with the help of androgen receptors and indirectly using estrogen receptors. However, more work is necessary to determine the exact differences between these effects.   High estradiol levels are not correlated with erectile dysfunction Contrary to the popular belief, high estradiol levels are not associated with poor sexual function in males. A study was conducted on low testosterone centers in the United States, comprising more than 34,000 men. The participants had different ages, some of them being younger than 25 while others being older than 65. Estradiol levels were measured using electro-chemiluminescence immunoassay and it has been discovered that having too much estradiol in the bloodstream doesn’t lead to poor sex drive and erectile dysfunction. It has also been discovered that those with low or normal estradiol levels have a higher incidence of poor sex drive and potential erectile dysfunction.   Estradiol improve endothelial function in healthy men Studies show that estradiol (sometimes written as oestradiol) can improve endothelial function in healthy men. The endothelium is a very thin membrane which lines up the insides of your blood vessels and heart. It can also be found on lymph vessels. Its role is to release substances which help relax or constrict the blood vessels, depending on various factors. The endothelium is also important for controlling platelets, blood clotting and to regulate immune function in men and women. It is already known that supplementing with estrogen (particularly estradiol) is linked to a reduced incidence of cardiovascular disease in women who are deficient in this hormone. The purpose of the study is to determine if estrogen can also be beneficial for the endothelial function in healthy men. The study included 23 men aged 32 years, give or take up to 8 years. They were split into three groups. One group was given testosterone supplements alone, one group received a combination of testosterone and 10mg of estradiol and the third group received testosterone and 20mg of estradiol. These participants were measured one month and six months after multiple tests were performed to determine the influence of estradiol on their health. The study concluded that those who received estradiol supplementation had a better endothelial function. This means that administering estradiol to healthy men can improve their cardiovascular system.   Estradiol and libido, erectile function and reproduction Estradiol impacts multiple processes in a human body and it can have a strong influence on the brain. This hormone can directly influence the brain and dictate the sexual behavior of mammals, creating arousal states and moods which are conducive to reproduction. This is done by the release of pheromones. These substances can increase activity in the area anterior to the hypothalamus. Neurons play an important role in converting testosterone to estrogen using the aromatase enzyme. There are billions of neurons in the brain and they transmit electrical information 24/7, helping humans function correctly. Another important brain cell is the astrocyte. These cells help the neurons transfer information from one part of the brain to the other. They are star-shaped cells which play an important role, particularly when the brain is injured and they also use the aromatase enzyme to convert testosterone to estrogen. The anterior area of the hypothalamus contains numerous estrogen receptors. These receptors work similarly to selective serotonin reuptake inhibitors which are known for lowering sex drive. This might indicate that estrogen can significantly influence sexual functioning and behaviors in men.   How estradiol works when testosterone levels are low Having low testosterone levels can definitely lead to poor sexual functioning and lack of libido. To determine the efficacy of estradiol in men and what influences it has, it is important to analyze it in people who have normal as well as low testosterone levels. Studies have been done on men with low testosterone. They received doses of estradiol and reported an increased sexual drive. These human studies are supported by the ones performed on rats. Castrated rodents were given estrogen and it has been discovered that this increased their sexual activity. Another important finding consists of patients who had prostate cancer and received androgen deprivation therapy. This type of therapy is known to slow down or completely stop the advancing of prostate cancer since the cancerous cells require testosterone to grow. When the androgen levels reached a critical point, the patients reported symptoms which are commonly found in people who have a low sex drive and erectile dysfunction such as hot flashes and other adverse effects. It has also been discovered that androgen receptor blockers are more efficient in maintaining sexual activity in comparison with castration. This might happen as a result of testosterone conversion to estrogen. It is possible that supplementing with estradiol might make patients who undertake androgen deprivation therapy have increased brain activity in those areas responsible with sexual behavior.   Estradiol and its influence in eugonadal men (men with normal testosterone levels.) Eugonadal means men with healthy testosterone levels. Estradiol has been proven beneficial for people with low testosterone levels, increasing libido, and sexual desire. However, some studies show that the same positive results don't apply to eugonadal men. One study was performed on men with healthy testosterone levels. They received estradiol on a regular basis and they reported a decrease in sexual functioning, libido, masturbation, and erections. On the other hand, another study reported that administering estradiol to 50 men aged between 20 and 40 years didn’t influence their sexual function and libido at all. More research is required to understand how estradiol affects eugonadal men, but administering this hormone exogenously can be beneficial for people who have testosterone levels, increasing their libido and sexual desire.   Analyzing the role of estradiol on hypogonadal men who undertake testosterone replacement therapy Testosterone supplementation therapy aims to improve the quality of life of hypogonadal men as well as increase the levels of circulating testosterone in their bloodstream. This therapy also tries to increase the number of testosterone metabolites such as estradiol which is known for playing a vital role in sexual desire. In a test performed on men with secondary hypogonadism, c l o mi phene was used to increase the levels of testosterone by influencing the estrogen receptors directly. Secondary hypogonadism means that the testicles function correctly, but there is a scarcity of luteinizing hormone produced by the pituitary gland and this translates into low testosterone levels. The clomiphene citrate managed to increase testosterone levels in men with secondary hypogonadism as well as increasing the conversion of testosterone to estrogen. Other studies show that clomiphene citrate can increase sexual desire and libido. Another study performed in 2013 looked at the role of testosterone in healthy men and how it can influence sexual behavior. Some of the study participants received testosterone in combination with aromatase inhibitors, while others received testosterone without aromatase inhibitors. As a result, the sexual function was impaired when aromatization was inhibited. Other studies show that sexual desire increased significantly when men received testosterone supplementation therapy and had estradiol levels above 5 ng/dl. Even when testosterone levels were below 300 ng/dl and the estradiol levels were higher than 5 ng/dl, the sexual desire was increased. Yet another study looked at the sexual behavior of men who received l etr ozole which is a powerful aromatase inhibitor. These men had low testosterone levels and after being given le tro zole, their estradiol level dropped even lower. The result was that libido was significantly decreased. This means that both testosterone and estradiol are important in people who have testosterone deficiency to achieve and maintain healthy sexual desire and libido.   Aromatase inhibition can decrease insulin sensitivity Insulin sensitivity is extremely important when it comes to diseases such as diabetes type 2. Those who have low insulin sensitivity are more predisposed to become diabetic in the future. Inhibiting the aromatase enzyme through different types of drugs can have a significant influence on insulin sensitivity in both humans and rats. A study conducted at a clinical research facility tested 17 healthy men with ages between 18 and 50 years. This was a double-blind, controlled study. Each participant received an aromatase inhibitor, or a placebo drug for 6 weeks. The study concluded that inhibiting aromatase can lead to poor insulin sensitivity, particularly when it comes to peripheral glucose disposal.   The relationship between estrogen and bodybuilding It is well known that estrogen gives you a feeling of wellbeing and the lack of it can lead to depression, mood swings, emotional instability, and even depressive thoughts. Aromatase inhibitors can reduce the amount of estrogen the body produces and it usually makes a person feel lethargic and unhappy. For example, menopausal women seem to become more emotionally unstable and being haunted by feelings of anxiety and depression. Studies show that this can also be the case for bodybuilders and top athletes who regularly take aromatase inhibitors to convert less testosterone to estrogen. Estrogen is vital when it comes to sexual drive and libido as well and it is a well-known fact that aromatase inhibitors can negatively impact sex drive. A study on two groups of men reached the conclusion that estrogen is very important for libido. The first group received testosterone treatment alone while the second group received testosterone and an anti-estrogenic agent. At the end of the test, the group who received only testosterone treatment had better sexual drive and libido. Researchers also believe that lowering the estrogen levels too much in healthy men can lead to anxiety feelings, depression and even osteoporosis.   Estradiol and DHT can make you age more slowly Another study performed in Australia looked at the link between telomere length and the amount of serum estradiol and DHT in men. Telomeres are sequences of nucleotides at the end of each chromosome. They are used as a biomarker for aging. Having shorter telomeres means that the biological age is higher, regardless of the actual age of the person. Having longer telomeres correlated with a smaller biological age which basically means that the person is younger than his or her real age. The study performed in Australia looked at the telomere lengths of men aged 53, give or take approximately 15 years. The conclusion of the study was that estradiol and DHT correlate with telomere length and a small reduction in estradiol can amount to an approximate age increase of a decade. Estradiol alone can influence telomere length and that’s why it is important not to reduce it too much using aromatase inhibitors.   Symptoms of low estradiol in men A study performed in a medical center on several hundred men concluded that lack of estradiol can give certain vasomotor symptoms similar to those menopausal women have. These symptoms include hot flashes, sweats and flushes. The study participants were healthy men with ages between 20 and 50 years. They had normal serum testosterone levels and were split into two groups The first group of men was administered goserelin acetate which stops gonadal steroids. After 4 weeks, they received placebo drugs or different doses of testosterone gels. The second group of men received a treatment similar to those in the first group, but they also received an inhibitor of the aromatization of testosterone to estrogen. The study concluded that those who received aromatase inhibitors and had low estradiol levels experienced vasomotor symptoms such as night sweats and hot flashes. Similarly, those who received high doses of testosterone gel (approx 10 grams daily), as well as aromatase inhibitors, didn't experience the same symptoms. This means that when high amounts of testosterone are administered, it can suppress the effect of the aromatase inhibitor and leave estrogen levels intact.   Estradiol and reproductive function in men The sexual function in males is directly influenced by a mix of multiple substances and organs including testosterone, estradiol, estrogen receptors, testes, penis, and brain. The aromatase enzyme and estrogen receptors have a similar location in the brain and they are important in the development of sexual function early in life. They also influence sexual behavior in adulthood in combination with other substances called pheromones. Estrogen influences the mood and libido of a man, enabling him to alter his cognition for a mental state conducive to reproduction. Spermatogenesis is another important part of male reproduction. The creation of sperm cells relies on estradiol and these cells contain estrogen receptors and the aromatase enzyme. Men who undertake testosterone supplementation therapy should also be monitored for their estrogen levels. This is because an estradiol level below 5ng/dl can cause a significant drop in sex drive and libido.   Conclusion The role of estrogen in the male body is unquestionably important. Bodybuilders, professional athletes, and patients who undertake testosterone replacement therapy should be careful when it comes to managing estradiol levels since this hormone can significantly impact their wellbeing, sex drive, and bone density.   Get Your Estradiol Blood Test and Find Out More!

Table of Contents What are Estradiol and Aromatase? When aromatase is unbalanced, estradiol becomes an issue Low estrogen levels in men, not testosterone increases risk of heart disease Androgen deprivation therapy can cause cognitive decline Does estradiol restore cognitive function during ADT? Should high estradiol levels be treated? What are Estradiol and Aromatase? Estradiol is a form of the female hormone estrogen. Although estradiol production is typically considered a female concern, men also need to maintain healthy levels of this hormone for optimal health. Since men lack ovaries (where most estradiol is produced in women), estradiol in men is created by a process that uses an enzyme called aromatase (1) in testicles, liver and fat cells. Aromatase converts a very small portion of testosterone levels into estradiol, and health problems can arise when aromatase levels are too high or too low (1). When aromatase is unbalanced, estradiol becomes an issue As men age, they can experience excess aromatase activity, raising estradiol levels and reducing testosterone to unhealthy levels. Low T levels will adversely impact quality of life by reducing libido, ability to maintain an erection, mood, and muscle mass, among other health factors (2). However, when the body produces too little aromatase, men can experience other, potentially serious health problems. Men with diminished aromatase levels will have an estradiol deficit, which can create problems similar to low-T; diminished sex drive, loss of bone mass, and increased body fat (3). Men on testosterone replacement therapy (TRT) taking higher doses of aromatase inhibitors can also experience estradiol deficit. Let’s look at recent studies finding that low estradiol can play a critical role in increasing the risk of cognitive decline and increase the odds of experiencing cardiovascular disease. Low estrogen levels in men, not testosterone increases risk of heart disease A study led by Elaine Yu, MD, MSc, addresses the suspicion held by many medical professionals that testosterone can promote cardiovascular disease in men, and that estradiol provides protection against it (4). The researchers sought to determine whether it was estradiol or testosterone that regulated men’s cardiovascular risk factors by comparing two groups whose hormone levels were changed using a combination of medications (4). They looked at 400 healthy men, between the ages of 20 and 50. Study participants were weighed, had fasting blood tests for markers of heart disease and diabetes, and also had a thigh scan using quantitative computed tomography (CT scan) to measure muscle fat content before and after the study (4). Yu’s team found that while higher levels of testosterone reduced these men’s levels of healthy (HDL) cholesterol, changes in estradiol levels had no effect at all on HDL(4). However, they also discovered that low estradiol levels did increase the markers for diabetes, like increased insulin resistance, increased fat in the muscles, and higher fasting blood sugar levels(4). Diabetes is a major risk factor for heart disease (5). Additionally, the study found that neither estradiol nor testosterone affected the levels of LDL (unhealthy) cholesterol. According to Yu, these findings indicate that in men, it’s higher testosterone levels combined with lower estradiol levels that can worsen cardiovascular risk factors, somewhat explaining differences in the incidence of heart disease between men and women. Some studies have shown that it is the ratio of testosterone to estradiol that is important, not just the level of each of those hormones. As testosterone increases with TRT, so does estradiol to balance the effects of testosterone on lipids, mood and insulin action. Androgen deprivation therapy can cause cognitive decline Androgen deprivation therapy (ADT) is an often used method to slow the growth of prostate cancer. It’s also used for men transitioning to women (6, 7). ADT is typically prescribed on an open-ended (no fixed period) basis to help treat advanced prostate cancer. An estimated 44 percent of men with prostate cancer will undergo ADT at some point as part of a strategy to slow tumor growth (6). ADT therapy is used specifically to block the male hormones, particularly testosterone, from stimulating prostate cancer cell growth. Research has confirmed that ADT can cause significant cognitive decline in women with breast cancer (8), but few studies have investigated cognitive impairment following ADT for men being treated for prostate cancer. Using formal tests, scientists recently compared the cognitive ability of 58 prostate cancer patients receiving androgen deprivation therapy to 84 prostate cancer patients who did not receive ADT, and 88 cancer-free men (9). They found that those treated with ADT were 70 percent more likely to develop cognitive impairment after six months, and over twice as likely to have significant cognitive impairment after one year(9).   Does estradiol restore cognitive function during ADT? A 2018 study published in Current Neuropharmacology has examined whether estradiol supplementation is an effective way to prevent this side effect (9). Researchers performed a literature search using PubMed and Google Scholar to identify studies on this topic and discover any evidence that estradiol supplementation has a cognitive benefit for men on ADT. They examined studies involving the effects of estradiol treatment on cognitive function in three androgen-deprived male populations; prostate cancer patients, male-to-female transsexuals, and castrated male animals (9). A review of the literature found that while some studies show that estradiol supplementation resulted in cognitive improvement (especially in spatial ability), They couldn’t determine (9): Whether estradiol will improve cognition after long-term ADT How early or delayed estradiol treatment post-castration will affect cognition If estradiol affects memory retention They conclude that for androgen-deprived males, there is some evidence that estradiol supplementation may improve both verbal and visual memory (9). However the variability between the reviewed studies resulted in significant inconsistencies, making further study necessary to determine what estradiol treatment protocol can best maximize cognitive improvement for men using ADT (9). Should high estradiol levels be treated? Men on testosterone replacement therapy can experience an increase in estradiol that can sometimes reach clinically elevated levels (10). A study published in the Journal of Sexual Medicine (11) looks at the phenomenon of increased estradiol levels in men undergoing TRT to discover whether high estradiol levels in this population should be treated. Researchers comprehensively reviewed the published literature on the role of estradiols in male sexual function and testosterone deficiency to answer this question. The study findings reveal that (11): Although estradiol have been used at pharmacologic doses to suppress serum testosterone, there is no evidence that naturally occurring elevations of estradiol will cause a reduction in testosterone levels Absent testosterone deficiency, study findings suggest that elevated estradiol levels don’t seem to be harmful. Once again, monitoring and treating the ratio of testosterone to estradiol may be more important than either hormone alone. Estradiol could help maintain some sexual function in castrated men Given the evidence uncovered by this review study, researchers report that, although further research is needed, the existing evidence doesn’t support the treatment of elevated estradiol for men on testosterone therapy (11). WATCH LECTURE ABOUT ESTRADIOL IN MEN    BUY YOUR SENSITIVE ESTRADIOL TEST   References 1) Stocco, Carlos. “Tissue Physiology and Pathology of Aromatase.” Steroids 77.1-2 (2012): 27–35. PMC. Web. 11 June 2018. 2) Araujo, Andre B., and Gary A. Wittert. “Endocrinology of the Aging Male.” Best practice & research. Clinical endocrinology & metabolism 25.2 (2011): 303–319. PMC. Web. 11 June 2018. 3) Bulun, Serdar E. “AROMATASE DEFICIENCY.” Fertility and sterility 101.2 (2014): 323–329. PMC. Web. 11 June 2018. 4) Men's heart disease risk linked to high testosterone and low estrogen. The Endocrine Society. 5) Zhang PY. Cardiovascular disease in diabetes. Eur Rev Med Pharmacol Sci. 2014;18(15):2205-14. 6) Perlmutter, Mark A, and Herbert Lepor. “Androgen Deprivation Therapy in the Treatment of Advanced Prostate Cancer.” Reviews in Urology 9.Suppl 1 (2007): S3–S8. Print. 7) Unger, Cécile A. “Hormone Therapy for Transgender Patients.” Translational Andrology and Urology 5.6 (2016): 877–884. PMC. Web. 11 June 2018. 8) Wu, Lisa M., and Ali Amidi. “Cognitive Impairment Following Hormone Therapy: Current Opinion of Research in Breast and Prostate Cancer Patients.” Current opinion in supportive and palliative care 11.1 (2017): 38–45. PMC. Web. 11 June 2018. 9) Wibowo E. Cognitive Impacts of Estrogen Treatment in Androgen-Deprived Males: What Needs to be Resolved. Curr Neuropharmacol. 2017;15(7):1043-1055. 10) Tan RS, Cook KR, Reilly WG. High estrogen in men after injectable testosterone therapy: the low T experience. Am J Mens Health. 2015 May;9(3):229-34. doi: 10.1177/1557988314539000. Epub 2014 Jun 13. 11) Ravi Kacker, Abdulmaged M. Traish, Abraham Morgentaler. Estrogens in Men: Clinical Implications for Sexual Function and the Treatment of Testosterone Deficiency. The Journal of Sexual Medicine. (2012): Volume 9, Issue 6, Pages 1681–1696

Historically, when we think of sex hormones in men and women, we identify testosterone as the core regulator of orderly male growth and sexual function. In a similar fashion, we identify estrogens as central to regulating sexual and reproductive function, along with a host of non-reproductive functions in women. 17ß-Estradiol or E2, the principal form of estrogen, is also produced in significant quantities in males. Research over the last two decades has demonstrated that estrogens can play a pivotal role in regulating male sex drive, erectile function, spermatogenesis, and can also be responsible for body fat distribution, bone density, and overall morbidity and mortality. High estradiol, however, is known to cause breast tissue growth (gynecomastia) and water retention in men with low testosterone. Because of this dynamic, regulation of the balance of testosterone and estradiol in men is paramount. Although there is evidence to suggest that lower levels of estradiol (10-20 pg/ml) can increase bone loss, the impact of high levels of estrogen on male reproductive function and other morbid conditions is complex, and it is difficult to discern upper values for the optimal range where deleterious effects begin to occur. The impact of both estrogen deficiency and excess remains controversial. We present here a background of estradiol in men along with studies that highlight the importance of estrogen in male physiology.   Video: Increased Estradiol Improved Sex Drive in Men   Estradiol in Men: Background As early as the 1930s, it was known that the male testis was responsive to estrogen and that exposure to high doses of estrogens causes developmental abnormalities. It was also speculated that the source of estrogen in males was the conversion from testosterone, which at the time was still considered the main “male hormone.” It wasn’t until the 1950s that conversion of testosterone to estrogen became well-documented. In the following decades, it became well-established that males produced significant quantities of estrogens and males of multiple species had quantifiable amounts of circulating estradiol that was synthesized in reproductive and non-reproductive tissues. In females, ovaries are the main source of circulating estrogens and regulate many facets of the female reproductive system. In males, it has been shown that the testes only produce approximately 20% of circulating estrogens, with the remainder being produced in tissues such as adipose, brain, bone, and skin, which convert testosterone to estrogens through the aromatase cytochrome P450. The diffuse pattern of estrogen production in men meant that there was no simple means to produce an estrogen-deficient state in the male comparable to an ovariectomized female. Thus, the role of estradiol and estrogen signaling in the normal male remained elusive due to a shortage of clear endpoints for estrogen action, as well as a lack of a good experimental model to approach the problem. One significant advancement in the field came in the 1970s when it was demonstrated that the testes were the major source of estrogens in men. Biochemical analysis on aromatization of androgens to estrogens and protein labeling studies for localization of estrogen receptors (ER) and the conversion enzyme aromatase in the testis were utilized to further characterize the system. New developments in the ‘80s and ‘90s led to the hypothesis that estrogen and its α-receptor were “essential” for normal fertility. Because of this, the interest in the implications of estrogen signaling in the male reproductive system increased toward the end of the century. Work over the last two decades in genetically modified mouse models, and the discovery of natural mutations in men helped to make major advances in the investigation of estrogen physiology in men. Studies further revealed that estrogens are critical for normal development and function of male reproductive and nonreproductive organs.   Sex Steroids and the Male Libido As mentioned earlier, testosterone has long been identified as the dominant sex hormone in men, and we now know that estradiol, previously thought to be only a female hormone, also plays a critical role in modulating libido, erectile function, and spermatogenesis. The extent of this role, however, is unclear and remains the subject of debate. There is an abundance of estrogen receptors, as well as aromatase in organs important to sexual function such as the brain, penis, and testis. Estradiol, therefore, can affect libido at multiple stages. Studies have indicated that decreased testosterone is associated with low libido in males. In these men, administration of exogenous estradiol can improve libido. It is known that higher testosterone levels in men can prompt higher estradiol levels through conversion of androgens like testosterone to estradiol. In male hypogonadism, a condition in which the body does not produce enough testosterone, testosterone replacement (or supplementation) therapy can improve quality of life. Testosterone therapy is prescribed for millions of men and the numbers are increasing yearly. Currently, testosterone therapy is more often used in patients with non-specific symptoms, such as sexual function and fatigue, when lab levels of testosterone fall below a certain criterion (2 standard deviations below the mean value for health young adults). Although the measure is helpful, it fails to address the physiological changes at certain testosterone levels or potential role of the associated decline in estrogens that may occur in androgen deficiency. Effect of Testosterone and Estradiol on Men's Libido: In an innovative study to address these concerns, one group recruited healthy males to determine the point at which undesirable changes begin to occur with testosterone deficiency, estrogen deficiency or both and whether these changes were androgen-dependent, estrogen-dependent or a combination of the two.(Finkelstein et al. 2013) 2 groups of males (20 to 50 years of age) with normal testosterone levels were given goserelin acetate (to suppress endogenous testosterone and estradiol) and randomly assigned them to receive varying amounts of 1% testosterone gel (0g, 1.25g, 2.5g, 5g, or 10g) for 16 weeks. One group also received an aromatase inhibitor to suppress the conversion of testosterone to estradiol. Over the 16-week period, changes in body fat percentage, lean mass, subcutaneous- and intraabdominal-fat areas, thigh-muscle area and strength, and sexual function were assessed. The findings of this study indicate that when estradiol production was intact, fat accumulation began with mild testosterone deficiency (about 300 to 350 ng per deciliter). Lean mass, thigh-muscle area, and muscle strength, however, were maintained until testosterone levels dropped below 200 ng per deciliter. Sexual desire and erectile function exhibited different patterns in response to changes in serum testosterone reduction. While changes in lean mass, thigh-muscle area, and leg-press strength were associated with variations in testosterone levels, changes in fat measures were associated with changes in estradiol levels. Also, both androgens and estrogens were responsible for the maintenance of libido and erectile function.   Low Estradiol and Fat Gain: Surprising Results This study provides important information regarding the interpretation of testosterone levels in young and middle-aged men. The authors indicate that the increases in intraabdominal fat with aromatase inhibition can foreshadow an increase in cardiovascular disease observed with long-term estrogen deficiency. Lastly, since lean mass, thigh-muscle area, and erectile function were reduced at a dose of testosterone that prompted a mean serum level of approximately 200 ng per deciliter (1.25g per day).   High Estrogen in Men: Studies In the past, there has been some concern with possible side effects of elevated estrogen levels (hyperestrogenism), such as fatigue, gynecomastia, diminished libido, and erectile dysfunction. A large retrospective study conducted at 35 Low T Centers sought to understand if there were predictive factors of patients who were more likely to develop high estradiol levels after testosterone replacement therapy. (Tan, Cook, and Reilly 2015) As part of the study, the researchers also incorporated the use of aromatase inhibitor (AI) such as anastrozole (Arimidex) and selective estrogen receptor modulators (SERM) such as tamoxifen (Nolvadex) to alleviate symptoms of hyperestrogenism. The trend in estradiol levels in the 4 age groups studied (<25, 25 to 44, 45 to 65, and >65 years) was analyzed. Estradiol was lowest in the <25 years age-group with a rise in the 2 middle age groups the gradually tapered in the oldest age group (>65 years). Much of the use of aromatase inhibitors was in the 2 middle age groups, resembling the prevalence of hyperestrogenism. Interestingly, it was determined that patients with lower estradiol (<42.6 pg/ml) had complaints of low libido. The authors also make note that despite the use of AI and SERM in 30% of the treatment population, side effects occurred in <1%. One additional study worth mentioning sought to determine the associations between serum testosterone, estradiol, and libido in men undergoing testosterone supplementation therapy for symptomatic hypogonadism (total testosterone <300 ng/dl and 3 or more symptoms on the Androgen Decline in Aging Male questionnaire [ADAM]). (Ramasamy et al. 2014) As part of the ADAM questionnaire, all men were asked to rate their libido on a 5-point scale. Men were categorized into low (<300 ng/dl) or high (>300 ng/dl) testosterone and low (0.5-5.0 ng/dl) and high (>5.0 ng/dl) estradiol. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), serum testosterone, and sex hormone-binding globulin (SHBG) were analyzed to evaluate factors predicting libido. Men with high serum testosterone and estradiol levels reported greater libido. In total, 60.4% of men with both high serum testosterone and estradiol levels reported a very good to excellent levels of libido on their questionnaire. When analyzing the combined data, only estradiol at serum levels >5 ng/dl was associated with a greater libido. The authors indicate several limitations of the study and despite the lack of proper controls, a small sample size, and absence of score comparison before and after initiation of therapy, the study emphasizes the importance of estradiol in men on testosterone. Another recent study showed that change in estradiol level was the best predictor not only of the change in bone mineral density (BMD) and sexual desire.    Conclusions: In a review of the clinical implications of estrogens for sexual function and testosterone replacement therapy, one group notes that estrogens may contribute to the persistence of sexually stimulated erectile function when serum testosterone is severely depressed. Naturally occurring elevations in estradiol do not appear to be harmful, and the incidence of symptoms of excess estrogens are rare. They also add that the use of aromatase inhibitors is not recommended for long-term use and recommend against the use of aromatase inhibitors in men that experience positive effects from testosterone therapy despite elevated estradiol concentrations. When used, an aromatase inhibitor should be titrated so that estradiol levels remain above 40 pmol/L to preserve bone health. It is important to mention that levels of circulating sex hormones are highly regulated via feedback loop of the hypothalamic-pituitary-gonadal (HPG) axis and on a tissue level with aromatase activity. As levels change, the body compensates. Caution should be taken when testosterone is used pharmacologically. It is difficult to compare the response from patient to patient because of many contributing factors and levels of testosterone alone may not give a clear picture of an individual’s disposition.   References Cooke PS, Nanjappa MK, Ko C, Prins GS, Hess RA. Estrogens in Male Physiology. Physiol Rev. 2017 Jul 1;97(3):995-1043. Finkelstein JS, Yu EW, Burnett-Bowie SA. Gonadal steroids and body composition, strength, and sexual function in men. N Engl J Med. 2013 Dec 19;369(25):2457. Tan RS, Cook KR, Reilly WG. High estrogen in men after injectable testosterone therapy: the low T experience. Am J Mens Health. 2015 May;9(3):229-34. Ramasamy R, Scovell JM, Kovac JR, Lipshultz LI. Elevated serum estradiol is associated with higher libido in men on testosterone supplementation therapy. Eur Urol. 2014 Jun;65(6):1224-5. Vermeulen A, Kaufman JM, Goemaere S, van Pottelberg I. Estradiol in elderly men. Aging Male. 2002 Jun;5(2):98-102. Kacker R, Traish AM, Morgentaler A. Estrogens in men: clinical implications for sexual function and the treatment of testosterone deficiency. J Sex Med. 2012 Jun;9(6):1681-96. Hess RA. Estrogen in the adult male reproductive tract: a review. Reprod Biol Endocrinol. 2003. Rochira V, Granata AR, Madeo B, Zirilli L, Rossi G, Carani C. Estrogens in males: what have we learned in the last 10 years? Asian J Androl. 2005 Mar;7(1):3-20. Schulster M, Bernie AM, Ramasamy R. The role of estradiol in male reproductive function. Asian J Androl. 2016 May-Jun;18(3):435-40. Blakemore J, Naftolin F. Aromatase: Contributions to Physiology and Disease in Women and Men. Physiology (Bethesda). 2016 Jul;31(4):258-69.

Estradiol is the most important female sex hormone, and it plays a significant role in developing female secondary sexual characteristics. It also plays a vital role in maintaining proper bone density, regulating body fat, and ensuring a strong erection in men. This type of hormone is one of the three estrogens found in the human body. The other two are called estrone and estriol. Estradiol is the most important and strongest of the estrogen hormones, and it is primarily made in testicles, fat cells, and liver. Approximately 80% of the estradiol found in a man's body comes from the aromatization of testosterone. A small amount of testosterone is converted to estradiol to maintain healthy reproductive and cognitive systems in men, among other body functions. Why is estradiol in men important? Because maintaining proper estradiol levels is paramount for ensuring the correct functioning of various body processes. For example, estradiol is involved in: · Maintaining correct HDL cholesterol levels · Improving penile sensitivity · Maintaining an emotional balance in men · Promoting high bone density There are numerous myths that circulate online when it comes to estradiol. Since this is a female sex hormone, some say that too much estradiol can give one "man boobs" or make him asexual. Although having very high estradiol levels can lead to various health issues, reducing the amount of estradiol in the body can also have negative consequences such as losing bone mass, having joint pains or having a decreased libido. Keep reading this article to learn more about estradiol and how it can negatively affect the body if it circulates in the blood in sub-optimal quantities.   Estradiol in Men Studies Maintaining optimum estradiol levels is key to flourishing health and enhanced fitness performance. There are several causes or factors which might disrupt proper estradiol balance and lead to very high or very low estradiol levels. · Various medications such as HIV meds, etc · Toxins from the environment · Various foods · Age · High Body Mass Index (BMI) To achieve correct estradiol levels in the organism, one needs to learn more about this type of hormone and find out how it influences the body. The following study analyzes how testosterone and estradiol can influence muscle development, strength and sexual function in men aged 20-50. Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men Study Purpose This study aims to identify a direct relationship between testosterone and estradiol in men and various body functions and processes such as fat accumulation, muscle development, and fitness performance, libido, and sex drive, etc. Approximately 80% of the estradiol currently found in men results from the aromatization of testosterone. When if the levels of testosterone go down, estradiol levels will also be reduced, and this might lead to changes in body composition. Study methods Two groups of 198 and 202 men participated in this study. They were healthy men aged 20-50 who were carefully monitored for over 16 weeks to find differences in body composition and fitness performance. The first 198 men were given goserelin acetate which is a substance that suppresses natural testosterone and estradiol levels. They were also given a placebo gel as well as testosterone gel in different concentrations such as 1.25 g, 2.5 g, 5 g, or 10 g. The gel was administered daily. The second group received the same treatment, but they were also given an aromatase inhibitor which is a substance that prevents the aromatization of testosterone into estradiol. Study conclusions Key factors were monitored in these 400 men to determine the influence of testosterone and estradiol on muscle performance and strength, sex drive, and fat development. The study concluded that the body fat percentage increased in men who received a placebo testosterone gel or 1.25 g or 2.5 g of testosterone gel without getting anastrozole. Lean muscle mass also decreased in these men, and leg-press strength showed a significant decrease only in men who received the placebo gel. The significant increases in body fat are attributed to estrogen deficiency (suppression of the aromatization process of testosterone). Both androgen and estrogen deficiency caused a significant decrease in sexual function which was represented by sexual desire and erectile function. Men who received the placebo gel or 1.25 g of testosterone gel experienced the most significant decrease in sexual function, as opposed to those who received a higher concentration of testosterone gel. The study was funded by the National Institutes of Health and determined that decreases in testosterone levels primarily influence muscle strength and performance, decreases in estradiol can lead to a higher subcutaneous and intraabdominal fat percentages, and both androgen and estrogen deficiencies can lead to poor sexual function. Let's take a look at more negative consequences which can appear as a result of having too little estradiol in the body. Why low estrogen levels are dangerous for health and decrease fitness performance As mentioned earlier, having less-than-optimal amounts of estrogen in the body can lead to multiple health problems in men of all ages. Let's discover how low estradiol levels can hinder fitness goals or affect health. 1. Low estrogen levels prevent the translocation of Glut-4. Muscle hypertrophy is essential for fitness professionals and the protein carrier Glut-4 can help with recovery and growth by transporting nutrients from the surface to the core of the cells. However, this protein can sometimes become stubborn and remain inactive for long periods of time. As a result, insufficient amounts of nutrients are carried from the surface to the interior of the cells which might make the muscle recovery process less efficient. The role of estrogen, in this case, is to make the translocation of the Glut-4 possible which leads to a higher amount of nutrients being delivered to muscle tissues for repair and growth. Having very low amounts of estrogen can prevent the activation of this protein carrier which is a significant loss for any fitness professional or bodybuilder. 2. Low estrogen levels allow myostatin to interfere with the muscle-building process. As you probably already know, myostatin is an important suppressor of muscle growth in both males and females. It can be extremely powerful as presented in various studies and experiments performed on animals. For example, animals which had their myostatin gene removed experienced dramatic increases in muscle mass, sometimes reaching up to 100% more muscle in comparison with animals which haven’t been genetically altered. Studies show that the elevated estrogen levels in women can prevent myostatin from interfering with the muscle-building process. By having very low levels of estrogen, the myostatin substance is free to suppress muscle growth which is something all fitness professionals want to avoid. 3. Low estrogen levels can worsen insulin resistance. Insulin, a substance produced by the pancreas, is essential for "unlocking" cells in the bloodstream, allowing them to absorb the existing glucose – a process which gives the human body energy to survive and to perform daily tasks. When cells develop insulin resistance (as a result of a sedentary lifestyle, among other factors), type 2 diabetes can result. Doctor Evelyn Yu, M.D., an endocrinologist at the Harvard University, concluded that estrogen deficiency could lead to a poor glycemic index as well as an increased resistance to insulin. Men and women of all ages can be affected by this, and that’s why it's important never to reduce the estrogen hormone to a dangerous level. Another study conducted on men aged 40-74 years determined the important role of high aromatase activity in the body. Let's take a closer look at its findings. High Aromatase Activity in Men with Low Testosterone Is Associated with Higher Spine BMD, Increased Truncal Fat Mass and Reduced Lean Mass Study Purpose This study strives to determine a relationship between spine BMD (bone mineral density) and aromatase activity in patients with low testosterone levels. Study Methods 90 men aged 40-74 years were carefully monitored during a genetic study on the effects of the aromatase enzyme on the bone mineral density. These men underwent testosterone replacement therapy as a result of low testosterone levels. Their body composition was analyzed using advanced tools such as dual-energy x-ray machines and enzyme immunoassay, among other medical equipment. Study Conclusions The study concluded that men who had the highest estradiol levels in comparison with testosterone also registered the highest spine bone mineral density. At the same time, their high aromatase activity leads to an increase in truncal fat as well as a significant decrease in lean body mass. The most important finding of this study is that despite having low circulating testosterone levels, high aromatase activity can lead to healthy musculoskeletal health in men over 40 years old. The direct relationship between estradiol and high bone density is visible in this study. Summary The role of estradiol in men's health cannot be denied. There are numerous benefits this hormone can provide to men of all ages if it circulates in the blood in optimal quantities. This article is part of a series of documents which outline important findings of scientific studies on estradiol. The more information one accumulates on estradiol, the better decisions he can make when it comes to achieving healthy estrogen levels in the body. One of the best ways to determine how much estradiol one has in his body is by using blood tests. This is an inexpensive and highly efficient method of knowing the exact estrogen and testosterone levels. Do you have any questions? Do you know more about estradiol or want to provide feedback? Use the comment section below to ask your questions about estradiol or share your knowledge with everyone!   More interesting reading: THE TOP 18 THINGS YOU DID NOT KNOW ABOUT ESTRADIOL'S ROLE IN MEN'S HEALTH

Testosterone Replacement Therapy (TRT) is a common treatment for men with low testosterone levels. While TRT can have numerous benefits, such as increased energy, libido, and muscle mass, it is important to monitor other hormone levels, specifically estradiol and dihydrotestosterone (DHT). While DHT is a metabolite of testosterone, estrogen is a form of estrogen that results from the aromatization of testosterone. Understanding the optimal levels of these hormones on TRT is crucial for achieving the desired effects while minimizing potential side effects. In this article, we will discuss a study conducted on young and older men using different doses of testosterone and its implications for predicting estradiol and DHT levels on TRT. Table of Contents The Study: Testosterone Injections and Estradiol/DHT Levels Results and Findings Estradiol Levels DHT Levels Predictive Model Interpreting the Findings Conclusion The Study: Testosterone Injections and Estradiol/DHT Levels The study in question was conducted by researchers at Boston University School of Medicine and published in the Journal of Clinical Endocrinology & Metabolism in 2010. The aim of the study was to investigate the effects of different doses of testosterone injections on estradiol and DHT levels in young and older men. The participants included 51 young men aged 19 to 35 and 50 older men aged 59 to 75. To conduct the study, the participants were administered a blocker to suppress their natural testosterone production. They were then given weekly injections of different doses of testosterone for a duration of five months. The researchers measured the participants' estradiol and DHT levels throughout the study to assess the impact of testosterone doses on these hormones.     Results and Findings The study revealed several interesting findings regarding estradiol and DHT levels in men on TRT. Here are some key points: Estradiol Levels The study found that estradiol levels increased with increasing doses of testosterone in both young and older men. However, the increase in estradiol was more significant in older men compared to younger men. This suggests that older men may have a higher propensity for aromatization, which is the conversion of testosterone into estradiol. It is important to note that the estradiol levels observed in the study were higher than the reference ranges provided by some laboratories, which are primarily derived from men not on TRT. DHT Levels DHT levels also increased with higher testosterone doses, but the difference between young and older men was not as pronounced as with estradiol. DHT is derived from testosterone through the action of the enzyme 5-alpha reductase. While DHT is often associated with androgenic side effects, such as male pattern baldness and prostate enlargement, its role in TRT is still not fully understood. Predictive Model To help predict estradiol and DHT levels based on testosterone dose, the researchers developed a mathematical model using the data from the study. The model provides equations to estimate estradiol and DHT levels based on total testosterone levels. These equations can be helpful for clinicians and individuals on TRT to better understand and predict their hormone levels. Interpreting the Findings The findings from this study have important implications for individuals on TRT. It is essential to recognize that estradiol levels on TRT may be higher than the reference ranges established for men not on TRT. This is because the reference ranges are typically derived from individuals with lower testosterone levels. It is crucial to consider the individual's specific situation and response to TRT when interpreting estradiol levels. Additionally, the study emphasizes the need for regular monitoring of hormone levels to ensure they are within a safe and optimal range. By measuring estradiol and DHT levels, healthcare providers can make informed decisions regarding dosage adjustments and potential interventions to manage any adverse effects. It is important to remember that individual responses to TRT can vary, and what may be considered an optimal hormone level for one person may not be the same for another. Factors such as age, overall health, and personal preferences should be taken into account when evaluating hormone levels and making treatment decisions. Conclusion Understanding the impact of testosterone replacement therapy on hormone levels, particularly estradiol and DHT, is crucial for optimizing the benefits and minimizing the risks associated with TRT. The study discussed in this article provides valuable insights into the effects of different testosterone doses on estradiol and DHT levels in men. It is essential for individuals on TRT to work closely with healthcare professionals who can monitor hormone levels regularly and guide them in making informed decisions about their treatment. The predictive model developed in the study can serve as a helpful tool in estimating estradiol and DHT levels based on testosterone dose, but individual variations should always be taken into account. By monitoring hormone levels and adjusting treatment accordingly, individuals on TRT can achieve the desired effects while minimizing potential side effects. Regular communication with healthcare providers is key to ensuring the effectiveness and safety of testosterone replacement therapy. Disclaimer: The information in this article is based on the findings of a specific study and should not replace personalized medical advice. Individuals on TRT should consult with qualified healthcare professionals to address their specific needs and concerns.    

Estradiol in Men: What is the Most Accurate Blood Test? Table of Contents Estradiol in Men: What is the Most Accurate Blood Test? Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men Objective: Design and Setting: Main Outcome Measures: Results: Conclusions: BUY SENSITIVE ESTRADIOL TEST HERE  Recent studies show the importance of estradiol in men and how low estradiol can be detrimental for not only for bone but also for sex drive. Low estradiol has also been linked to fat gain. So, physicians should be careful about treating men who are obviously being over diagnosed with high estradiol due to the use of the wrong test. This study compares the old estradiol blood test assay (ECLIA) to the more accurate sensitive one (LC/MS/MS). The sensitive estradiol test is a method for measuring estradiol levels in men (and children) using a sensitive liquid chromatography-tandem mass spectrometry (LC/MS)-based assay[2]. It is considered more accurate for men because it provides better sensitivity and accuracy at lower estradiol concentrations, which are typically found in men, as opposed to higher concentrations found in adult females[1][2]. Immunoassay-based estradiol tests, on the other hand, perform best at higher concentrations of estradiol, making them more suitable for individuals with levels in the adult-female range[2]. The sensitive estradiol test, with its greater sensitivity at lower levels, is more appropriate for men who generally have lower levels of estradiol compared to adult females[3]. Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men  (Source: The Journal of Clinical Endocrinology & Metabolism, Volume 98, Issue 6, 1 June 2013, Pages E1097–E110)   Immunoassay-based techniques, routinely used to measure serum estradiol (E2), are known to have reduced specificity, especially at lower concentrations, when compared with the gold standard technique of mass spectrometry (MS). Different measurement techniques may be responsible for the conflicting results of associations between serum E2 and clinical phenotypes in men. Objective: Our objective was to compare immunoassay and MS measurements of E2 levels in men and evaluate associations with clinical phenotypes. Design and Setting: Middle-aged and older male subjects participating in the population-based Osteoporotic Fractures in Men (MrOS) Sweden study (n = 2599), MrOS US (n = 688), and the European Male Aging Study (n = 2908) were included. Main Outcome Measures: Immunoassay and MS measurements of serum E2 were compared and related to bone mineral density (BMD; measured by dual energy x-ray absorptiometry) and ankle-brachial index. Results: Within each cohort, serum E2 levels obtained by immunoassay and MS correlated moderately (Spearman rank correlation coefficient rS 0.53–0.76). Serum C-reactive protein (CRP) levels associated significantly (albeit to a low extent, rS = 0.29) with immunoassay E2 but not with MS E2 levels. Similar associations of immunoassay E2 and MS E2 were seen with lumbar spine and total hip BMD, independent of serum CRP. However, immunoassay E2, but not MS E2, associated inversely with ankle-brachial index, and this correlation was lost after adjustment for CRP (C Reactive Protein- An Inflammatory marker). Conclusions: Our findings suggest interference in the immunoassay E2 analyses, possibly by CRP or a CRP-associated factor. Although associations with BMD remain unaffected, this might imply for a reevaluation of previous association studies between immunoassay E2 levels and inflammation-related outcomes. BUY SENSITIVE ESTRADIOL TEST HERE