Men's health is all over the internet, but it can be difficult to locate trustworthy, evidence-based materials on testosterone replacement treatment (TRT). With an emphasis on hormone optimization and testosterone replacement therapy, ExcelMale.com has become among the most renowned and thorough forums devoted to men's health. The structure, content, and value of the ExcelMale forum—a tool for males looking for information on TRT and other subjects—are investigated in this paper. Nelson Vergel, a chemical engineer who converted his own health path into a mission to teach others, started Excel Male. Vergel started looking at hormone treatments and men's health after learning he had HIV more than 34 years ago, finally building one of the biggest internet groups devoted to these issues. ExcelMale currently counts over 44,000 members, including doctors, pharmacists, nutritionists, exercise trainers, nutritional supplement specialists, and other field professionals. These are educated men. This variety of experience fosters a special setting whereby medical knowledge is blended with practical practice. Since its founding, the forum has steadily expanded and became fast known as a leader in men's health. ExcelMale distinguishes itself from other online groups by means of strict moderation. Every post is checked daily to stop abuse and spam, so guaranteeing the site stays a trustworthy and safe source of knowledge. ExcelMale's dedication to quality control has helped it to establish itself as among the best moderated men's health forums available online. Forum Structure and Content Categories ExcelMale addresses a wide spectrum of men's health issues, with testosterone replacement treatment central in many of the conversations. The discussion is broken up into several categories covering many facets of hormonal health and optimization. The TRT Forum is a primary hub where people may network, exchange stories, ask questions, and find pertinent information. Forum topics cover Trimix injections for erectile dysfunction, HCG use for fertility and libido improvement, estradiol management, thyroid function optimization, peptide information, exercise routines, nutritional supplements, effective diets, and management of TRT side effects, well beyond simple TRT knowledge. This all-encompassing approach acknowledges that many facets of general welfare are related with hormonal health. Apart from the discussion boards, ExcelMale offers instructional materials like videos, seminars, articles, and expert interviews. Members can also post reviews of TRT clinics, doctors, compounding pharmacies, pharmaceutical items, and supplements, as well as participate in blood test conversations. This multifarious technique of content delivery guarantees that people may obtain knowledge in whatever format suits them most. Scientific Priority and Evidence-Based Methodology ExcelMale distinguishes itself in part by its dedication to scientific accuracy and evidence-based knowledge. As seen by their thorough response to a Veterans Administration study on testosterone therapy and cardiovascular risk, the forum does not hold back when examining and challenging scientific studies. ExcelMale found major methodological errors in their research, including poor patient monitoring and lower than ideal testosterone levels attained throughout treatment. ExcelMale stresses the need of accurate testing and observation throughout TRT. Comprehensive hormone testing should, they observe, include estradiol, thyroid function, and hematocrit (red blood cell volume), among other criteria, in addition to evaluating testosterone levels. This is consistent with advice from respected medical groups, including the European Association of Urology, the American Society of Reproductive Medicine, the Endocrine Society, and the American Association of Clinical Endocrinologists. The forum also helps one understand what ideal hormone levels are. For example, they reference studies showing that males with total testosterone blood levels above 550 ng/dl can lower their cardiovascular risk by 30%, but levels below this level may raise risk. This type of targeted, scientifically supported knowledge enables participants to create reasonable expectations on their path of hormone optimization. Correcting Typical TRT Misconceptions ExcelMale's material devotes a lot of space to dispelling myths about testosterone replacement treatment. These cover worries about prostate cancer, deep vein thrombosis, and cardiovascular risk. Experts such as urologist with more than 100 publications, Dr. Mohit Khera, address these subjects and offer evidence-based viewpoints in the forum through interviews. One frequent misunderstanding covered on the topic is the association between testosterone and prostate cancer. Although more recent studies have contradicting traditional medical wisdom, which has advised against testosterone treatment for individuals with a past of prostate cancer, ExcelMale helps members grasp the present level of scientific knowledge by offering information on these changing points of view. Still another myth is regarding estradiol's part in men's health. Although estrogen is usually thought of as a female hormone, estradiol is very important for male sexual function in terms of libido, erectile action, and spermatogenesis. ExcelMale emphasizes the need of balanced hormone levels rather than only boosting testosterone since it offers thorough information about how both low testosterone and raised estrogen can independently enhance the prevalence of erectile dysfunction. Help for Men Having Particular Health Issues Beyond broad conversations regarding TRT, ExcelMale offers men struggling with particular medical problems help. Common issues discussed on the site are erectile dysfunction, with threads looking at several possible causes including hormone imbalances, psychological elements, and physical diseases. One thread describes, for example, the experience of a 32-year-old guy who has battled erectile dysfunction for 15 years despite normal testosterone levels (550 ng/dL). Other hormonal elements, pelvic floor dysfunction, and the likely influence of pornography consumption are among the few possible explanations discussed outside simply testosterone insufficiency. This multifarious approach to difficult medical problems shows the forum's dedication to go beyond basic remedies and take full person into account. The discussion also covers supplementary treatments that could either enhance TRT or act as substitutes in some situations. These comprise clomiphene citrate for raising testosterone levels and thereby improving hormone ratios and human chorionic gonadotropin (HCG) for enhanced fertility and libido. ExcelMale gives members a more whole awareness of the several ways to optimize hormones by investigating these alternatives. Learning Tools and Professional Contributions ExcelMale sets itself apart with its abundance of instructional tools and professional inputs. Leading experts in men's health conduct interviews for the forum, therefore giving members access to innovative ideas and information. Among other medical specialists who specialize in hormone treatment and men's health, these experts include urologists, endocrinologists. Through his podcast "Beyond Testosterone," in which he interviews professionals and refutes ideas on testosterone and other hormones influencing men's health, Nelson Vergel personally makes a major contribution to the educational materials. From estradiol maintenance to the use of HCG in men, these interviews probe particular facets of hormone treatment. The forum provides a space for talking about scientific publications and studies on men's health as well. This keeps members current on the most recent advancements in their profession and clarifies how fresh studies could affect their personal medical selections. ExcelMale helps to close the gap between scholarly research and useful application by making difficult scientific material available to laypeople. Community Attributes and Peer Support The feeling of camaraderie and peer support ExcelMale offers is maybe one of its most useful features. Men with hormone problems can feel alone and could find it difficult to get understanding from friends, relatives, or even doctors. The forum provides a venue whereby these men may interact with others who have gone through similar events, exchange their hardships, and grow personally from one another's paths. This peer help goes beyond simple emotional encouragement. Members provide useful recommendations based on their own experiences with several treatment approaches, doctors, and supplements. They talk about how they have controlled side effects, adjusted their hormone levels, and included hormone treatment into their general wellness program. This kind of practical understanding enhances the more clinical expertise doctors offer. Members of the community also provide reviews of TRT clinics, doctors, compounding pharmacies, and different men's health goods, therefore acting as a collective knowledge base. This guides new members toward reliable providers and goods across the sometimes difficult terrain of hormone treatment. Female Health Knowledge ExcelMale mostly discusses men's health, but the forum acknowledges the interdependence of health issues and features a section specifically called "ExcelFemale" addressing hormone replacement therapy for women. This inclusion respects the fact that many men on the forum are looking for information not just for the significant women in their life but also for themselves. ExcelMale builds a more complete health information system by offering tools on female hormone therapy. This approach acknowledges that everyone's hormonal health is vital and that same ideas—appropriate testing, monitoring, and tailored treatment—apply regardless of gender. Relationship with Commercial Businesses ExcelMale has relationships to commercial companies in the hormone health field, which is noteworthy. ExcelMale's founder, Nelson Vergel, also started DiscountedLabs.com, a site offering reasonably priced blood tests. On the forum and in connected media, this connection is freely admitted. Although economic interests can occasionally generate questions regarding bias, ExcelMale seems to keep editorial independence and dedication to evidence-based knowledge. The forum's readiness to scrutinize studies and offer complex viewpoints on divisive subjects points to the fact that economic interests do not supersede their dedication to factual accuracy. In essence, conclusion ExcelMale is a great tool for men looking for knowledge on testosterone replacement treatment and associated issues of hormonal health. Its special platform in the internet health information scene is created by its mix of professional expertise, peer assistance, and thorough coverage of pertinent issues. The forum's focus on appropriate testing, surveillance, and tailored treatment fits best standards in hormone treatment. ExcelMale advocates a more complete approach to men's health that takes the complicated interaction between several hormonal systems into account by supporting thorough hormone assessment beyond simply testosterone levels. ExcelMale provides not only information but also a community of support for guys thinking about or now undergoing testosterone replacement treatment. Having access to evidence-based knowledge and the experiences of others can be rather helpful for making wise decisions about one's health in a field of medicine that is sometimes poorly understood and prone to misinterpretation. Forums like ExcelMale are crucial in sharing fresh discoveries and guiding men on how these changes can impact their individual health paths as research on testosterone treatment develops changes in direction. ExcelMale greatly enhances men's hormonal health and general well-being by closing the gap between scientific study and practical implementation.   Reference: ExcelMale.com Forum  

Key Highlights Discover the importance of testosterone testing and its impact on men's health. Explore a curated selection of reputable online labs offering competitive prices. Learn insider tips to save money, including promotional codes and leveraging insurance. Find answers to frequently asked questions about testosterone testing and its significance. Understand the value of DiscountedLabs.com for affordable and convenient testing options. Get insights into interpreting your test results and discussing them with a healthcare provider. Introduction In men's health, knowing your testosterone levels is very important. A basic testosterone blood test, also known as the T test, measures this key sex hormone. It can give you helpful information about your overall health and well-being, and plays a crucial role in diagnosing and treating hormonal imbalances like low testosterone (male hypogonadism) and monitoring hormone replacement therapy, such as testosterone therapy. As men get older, testosterone levels often go down, which can cause health problems. This blog will introduce you to the importance of testosterone testing and the men's health test price online. It will give you the knowledge you need to make good choices about your health with the guidance of a health care provider. Top Picks for Best Testosterone Test Prices Online Finding a cheap and trustworthy testosterone test is easier than you might expect. Many online labs now offer fair prices and easy testing options. These labs let you order tests online and then go to a nearby lab to give a sample. We will look at some of the best options for testosterone test prices online. We will think about things like cost, ease of use, and expert ratings. Also, we will share tips for finding a good and reliable provider for your testosterone testing needs. Where to Find the Best Prices for Testosterone Tests When you want to find the best testosterone test price online, it's important to compare prices from different labs. This means looking at the total costs, which includes the test price, shipping fees, and any extra charges. Good online labs usually share clear pricing information on their websites, making it easy to compare. Additionally, be sure to check if the lab offers a secure online portal for accessing your test results, as this can provide convenience and peace of mind. It is also important to consider the quality of the lab and their laboratory tests, as accurate and reliable results are crucial for making informed decisions about your health. Here are the prices for the "Testosterone, Free (Equilibrium Dialysis) and Total, MS" test from different labs: DiscountedLabs.com: $45.15 minus coupon: 10percentoff = $ 40.63 Ulta Lab Tests: $ 59 WalkinLabs: $68 PrivateMDLabs: $85   Keep in mind that just choosing the lab with the lowest price may not be the best way to go. Check for labs that are certified, follow privacy rules, and have good reviews from customers. 2. DiscountedLabs.com: Unbeatable Deals and Offers on Testosterone Tests DiscountedLabs.com is a leader in offering affordable testosterone tests. The website makes it easy for you to find and compare different testosterone test options and prices. They work with certified labs, so you can trust the accuracy of your test results. What makes DiscountedLabs.com unique is its focus on keeping costs low. The site often has special deals, discounts, and package offers, making it easier for more people to get testosterone tested. If you have a healthcare provider who uses a certain lab, DiscountedLabs.com can help you with that, too, so your testing is hassle-free. By focusing on convenience and low prices, DiscountedLabs.com helps people take charge of their health and understand their testosterone levels better. 3. Specialized Testosterone Test Packages for Varied Needs Understanding testosterone testing can feel confusing. But, many online labs now offer special test packages just for you. This personalized approach makes the testing easier and helps you get the right information. For example, if you worry about low testosterone, some labs provide packages that include a total testosterone test. These packages may also have other important hormone tests, like free testosterone and sex hormone-binding globulin (SHBG). Together, they give a better look at your hormone levels, including free testosterone levels. This helps healthcare providers make smart decisions and suggest the right treatments from specialized testing centers, such as specialty testing laboratories within the national network of primary clinical laboratories that perform regular quality assurance testing. 4. Insider Tips on Finding Promotional Codes and Discounts Saving money on testosterone tests is possible. Smart shoppers can use different ways to lower the costs of keeping track of their health. Here are some helpful tips to find promo codes and discounts for testosterone tests: Sign up for Lab Newsletters: Online labs often send exclusive deals and promo codes to their email subscribers. Follow on Social Media: Discounted Labs shares discounts and special offers on Facebook. Check Health Insurance: Sometimes, your health insurance might cover part or all of the cost of testosterone testing if it is needed for medical reasons. Using these money-saving tips can make testosterone testing easier. This way, you can focus on your health without spending too much. 5. Understanding the Value of Bundle Testing Options For people who want to keep track of their testosterone levels over a long period of time, bundling testing options using panels can save them money. Online labs usually give you lower prices when you buy several tests at once. This is especially helpful if you will need regular testosterone tests, like if you are on hormone replacement therapy. Here are other testosterone-related panels available on Discounted Labs: Testosterone (T+F), Estradiol and DHT Panel Testosterone (T+F), Hematocrit, Ultra Sensitive Estradiol and Prolactin Panel Testosterone (Total + Free), Ultrasensitive Estradiol & Hematocrit Testosterone + LH + FSH Panel Testosterone, Free (Equilibrium Dialysis) and Total, MS Testosterone, Free, Bioavailable and Total (With Lower & Upper Limit) plus SHBG Testosterone, SHBG, Hematocrit, Sensitive Estradiol and PSA Testosterone, Thyroid and Estradiol Panel Testosterone, Total ( LC/MS), Free T (Equilibrium Dialysis), Bioavailable T, and SHBG Testosterone, Total and Free (NO Upper Limit) plus Hematocrit Pre- TRT MALE Hormone / Wellness Panel TRT Basic Monitoring Panel TRT MALE Hormone/Wellness Follow Up Panel Buying in bulk (also called bundling) not only lowers the cost for each test but also makes it easier because you don't have to place separate orders each time. It is a good option for people who want to stay on top of their health. But remember to check the expiration dates of the test kits when you buy in bulk. By thinking about your needs and the savings from bulk testing, you can make smart choices about how to manage your budget for testosterone monitoring. Why Testosterone Levels Matter for Men Testosterone is mostly known as the male sex hormone. However, it does much more than just impact sexual health. It also helps with muscle growth, bone density, mood, and brain function. For men of all ages, keeping testosterone levels healthy is key to overall well-being. When testosterone levels are off balance, it can cause various changes. These changes can be physical, emotional, or mental. It's important to recognize the signs and symptoms of low testosterone. This way, you can get medical help and look into possible treatments. The Critical Role of Testosterone in Male Health Testosterone is the main male sex hormone. It helps many important functions in a man's body. Besides its known role in sex drive and sperm production, testosterone also affects muscle mass, bone density, and red blood cell production. It is important to keep healthy testosterone levels. This helps with strong bones, better muscle growth and strength, and keeps energy levels up. Testosterone, a vital sex hormone in those assigned male at birth, is also a key hormone for mood, thinking, and heart health, as well as fat distribution in the body. In men, testosterone helps regulate sex drive and erectile function, muscle mass and strength, body fat distribution, bone density, and production of red blood cells and sperm. Low levels of testosterone or "low T," may cause a variety of health challenges and changes to your overall health and physical appearance. As men get older, their testosterone levels drop. This can lead to lower sex drive, less muscle mass, and more tiredness. Understanding how testosterone affects male health is crucial. It shows why men should check their levels and get help from experts if there are any issues. Signs and Symptoms of Low Testosterone Levels Low testosterone, known as hypogonadism, can show up in different ways. It can affect your body and mind. Common signs include a lower sex drive, problems with erections, less muscle mass, and feeling more tired. Men with low testosterone might also see changes in their body, like more body fat and weaker bones. This condition can also affect feelings and thoughts, causing mood swings, irritability, trouble focusing, and sleep issues. It's important to notice these signs as possible signs of low testosterone. If you see any of these symptoms, it's good to talk to a healthcare professional about testing and treatment options. Long-Term Health Implications of Imbalanced Testosterone Maintaining balanced hormone levels is important for your health and well-being. Testosterone is the main male sex hormone. It plays a key role in many body functions. If its levels are too low, it can lead to serious long-term health problems. Low testosterone levels can increase the risk of health issues like heart disease, osteoporosis, type 2 diabetes, and metabolic syndrome. They can also lead to mood problems, sleep issues, and problems with thinking. Managing testosterone levels is important. Regular check-ups, changes in lifestyle, and the right medical help can lower the chances of these health issues. This can also improve your overall quality of life. Differences, Advantages, and Disadvantages of Different Testosterone Tests 1. At-Home Testosterone Kits   - Collection Method: At-home testosterone kits typically involve collecting a blood or saliva sample using a finger prick or saliva swab.   - Advantages:    - Convenience: At-home testosterone kits provide the convenience of testing testosterone levels from the comfort of your own home.    - Privacy: Some individuals may prefer the privacy of conducting the test at home.   - Disadvantages:     - Limited Accuracy: At-home testosterone kits may have limitations in terms of accuracy and reliability compared to tests conducted in a clinical setting.    - Lack of Professional Interpretation: Results from at-home kits may not come with professional interpretation, requiring individuals to seek medical advice for proper understanding and guidance. 2. Saliva Testosterone Test   - Collection Method: Saliva testosterone tests involve collecting a saliva sample using a swab or collection device.   - Advantages:    - Non-Invasive: Saliva testosterone tests are non-invasive and can be easily self-administered.    - Convenient: Saliva samples can be collected at any time and do not require a blood draw.   - Disadvantages:    - Limited Availability: Saliva testosterone tests may not be as widely available as blood tests.    - Potential Variability: Saliva testosterone levels may not always accurately reflect total testosterone levels in the blood. 3. LC/MS/MS Total Testosterone Test   - Collection Method: The LC/MS/MS (Liquid Chromatography-Mass Spectrometry) total testosterone test requires a blood sample typically collected from a vein in the arm.   - Advantages:    - High Accuracy: LC/MS/MS is considered a highly accurate method for measuring total testosterone levels.    - No Upper or Lower Limit: Unlike the immunoassay testosterone test, the LC/MS testosterone test is accurate at very low or very high testosterone blood levels.   - Widely Accepted: LC/MS/MS is a commonly used method in clinical settings for testosterone testing.   - No interference by supplements like biotin.   - Disadvantages:     - Requires a Blood Draw: Some individuals may find the process of having blood drawn uncomfortable or inconvenient.    - Laboratory Processing Time: Results from LC/MS/MS tests may take longer to obtain compared to rapid tests. 4. Immunoassay-Based Testosterone Test   - Collection Method: Immunoassay-based testosterone tests also require a blood sample, typically collected from a vein in the arm.   - Advantages:    - Rapid Results: Immunoassay-based tests can provide relatively quick results.    - Cost-Effective: Immunoassay-based tests are generally more cost-effective compared to LC/MS/MS tests .  - Disadvantages:    - Potential for Interference: Immunoassay-based tests may be susceptible to interference from certain substances or conditions, potentially affecting accuracy.    - Lower Sensitivity: Immunoassay-based tests may have lower sensitivity compared to LC/MS/MS tests. It is important to note that the choice of testosterone test should be made in consultation with a healthcare professional. They can guide you in selecting the most appropriate test based on your specific needs, medical history, and the accuracy and reliability of the available testing methods. How to Choose the Right Testosterone Test for You Choosing the right testosterone test depends on your needs and talking with a healthcare provider. Your medical history, symptoms, and the possible cause of hormonal issues are important in selecting the best test. A good first step is the total testosterone test. This test checks the total amount of testosterone in your blood. If the first results show any issues, a free testosterone test might be suggested. Free testosterone is the active part of the hormone that your body can use easily. Working together with your healthcare provider helps in picking a testosterone test. This way, you can get the best information to help with your health concerns. The Importance of Accuracy and Reliability in Test Results When you get testosterone tested, it is very important to have test results that are accurate and reliable. If the results are wrong, it can cause misdiagnoses, lead to bad treatment plans, and create unnecessary stress. You should pick testing providers that care about quality control. If you use at-home testing kits, carefully follow the instructions. Proper sample collection is key to reducing mistakes. Talk about any worries regarding test accuracy and reliability with your healthcare provider. They can help you understand your results and suggest trusted testing facilities, if necessary. Before You Buy: Understanding Testosterone Tests Beginning the journey of testosterone testing means you need to understand what these tests are and why they matter for men's health. Testosterone tests check the amount of testosterone in the blood. This hormone plays a key role in male sexual growth and function. Before getting a test, it is important to know the different types of testosterone tests. You should also understand what information they can provide and what things might affect test results. Deciphering Test Results: Free Testosterone vs. Total Testosterone Interpreting testosterone test results means knowing the difference between free testosterone and total testosterone. Total testosterone shows the overall amount of testosterone, while free testosterone shows the part that is active and works in the body. A normal range for total testosterone in adult males is usually between 300 and 1,000 nanograms per deciliter (ng/dL). This range can change a bit based on the lab. Free testosterone usually makes up about 2% of total testosterone. When looking at test results, it is important to think about both free and total testosterone levels. You should also consider your age, your overall health, and any symptoms you may have. A healthcare provider can help you understand your results and decide on the next steps. Preparing for Your Testosterone Test: Do's and Don'ts To get accurate and reliable testosterone test results, you need to follow certain preparation steps. These steps help reduce the effect of things outside your control that might change the results. Here's a list of do's and don'ts to remember: Do's: Schedule the test for the morning. This is when testosterone levels are usually at their highest. Check with your testing provider about fasting requirements. Most testosterone tests do not require fasting, but some specific panels may have different requirements. Don'ts: Avoid heavy exercise. Hard workouts can raise testosterone levels for a short time. Don't drink alcohol. Alcohol can affect hormone levels and change the results. By following these tips, you can help ensure that your testosterone test shows the true state of your hormones. This will help you make better health choices. When to Consider Retesting: Timing and Frequency The time for testosterone testing depends on your situation and why you were first tested. If you had testing done to find a specific issue or to check how well treatment is working, your healthcare provider might suggest regular retesting. If your testosterone levels are normal and you have no major symptoms, you may not need to retest right away. Still, checking periodically is a good idea, especially as men get older. This helps keep track of any changes in hormones and can help catch issues early. Changes in your lifestyle, medications, or new symptoms could mean you need to test again. It's important to talk to your healthcare provider about a plan just for you. This way, you can take the best steps to keep your hormonal health in good shape. Interpreting Your Testosterone Test Results: A Comprehensive Guide Understanding testosterone test results involves looking at many factors that can affect hormone levels. It's important to talk to a healthcare provider for accurate reading and advice that suits you. Labs usually give a reference range for normal testosterone levels. These ranges might be a little different from one lab to another. Also, your personal situation plays a part in determining what levels are best for you. Factors such as age, overall health, medications, and any symptoms matter when thinking about what your results mean. It is important to note that test results are interpreted in the context of your specific health situation, and your doctor may recommend repeat testing or additional tests to learn more about what may be causing your symptoms and/or the change in your testosterone level and potential medical conditions, such as polycystic ovary syndrome (PCOS). Your healthcare provider will look at these factors along with your test results to check for any hormone issues. Next Steps: Managing Low or High Testosterone Levels Once you get your testosterone test results, what you do next depends on whether your levels are normal or not. If your levels are outside the normal range, your healthcare provider will suggest a plan made just for you. If you have low testosterone levels, testosterone replacement therapy (TRT) might be a good choice. TRT adds testosterone to your body using different methods like injections, gels, patches, or pellets. Sometimes, treating other health issues like obesity, diabetes, or thyroid problems can boost testosterone production. How to Find a Good Testosterone Doctor. Maximizing Savings on Testosterone Tests Taking care of your health doesn't have to cost a lot. There are many ways to save money on testosterone tests and still get good quality and accurate results. You can start by knowing what your insurance covers. You can also look into other testing choices. By taking charge of your testing costs, you can focus on your health while keeping an eye on your budget. Leveraging Health Insurance and HSA/FSA Accounts Maximizing your health insurance benefits and using tax-advantaged accounts like Health Savings Accounts (HSAs) or Flexible Spending Accounts (FSAs) can help you save money on testosterone testing. Before you have any tests done, check your health insurance policy or speak to your provider. This will help you find out if testosterone tests are covered. Some plans may cover everything for diagnostic reasons, while others might require you to pay part of the cost or meet a deductible. If you have an HSA or FSA, you can often use that money to pay for eligible costs, including testosterone testing. This can further lower your out-of-pocket expenses. By knowing how to use these financial tools well, you can make healthcare easier to access. Conclusion In conclusion, it is important to maintain balanced testosterone levels for the health and well-being of men. There are many online options for testosterone testing. You should look through them to find the best one for your needs. Keeping track of your test results can help you manage any imbalances effectively. When choosing a testosterone test provider, consider things like accuracy, reliability, and cost. By staying informed and active about your testosterone levels, you can improve your overall health. Start exploring the various testosterone testing options online for a better journey toward health. Frequently Asked Questions What is the average cost of a testosterone test online? The cost of a testosterone test online can change quite a bit. Usually, prices are between $49 and $200. This depends on the lab, the type of test, and any extra services offered. To understand the prices in your area better, it's a good idea to talk to your healthcare provider or look at online lab websites. How often should I check my testosterone levels? The amount of testosterone testing needed varies from person to person. It depends on your health and specific situation. Your healthcare provider can help you decide how often to get retested. They will consider things like your age, symptoms, and any health issues you may have. Can I trust the accuracy of online testosterone tests? The accuracy of online testosterone tests can change based on the provider and the type of test. Choose reliable online labs that work with certified labs and focus on quality. For extra comfort, talk about your test results with your healthcare provider. Are there any risks involved with testosterone testing? Testosterone testing is safe, whether you do it in a lab or with an at-home kit. There can be small risks, like bruising, bleeding, or infection, where the sample collection happens. These issues are rare and usually not serious. If you have any worries, talk to your healthcare provider.

The Top Boner Killers What Causes an Erection? The Role of Blood Flow An erection begins when the penile smooth muscle relaxes, enabling blood to fill the corpus cavernosum, two cylindrical “caverns” of spongy tissue running within the penis. Stage two of the erection process occurs with this infilling of the corpus cavernosum. The inflow of blood expands the spongy tissue, which begins to pinch off the emissary veins of the penis, decreasing outflow, and—voila!—the erection begins to build. Continue reading this article to find out what the top erection killers are and how to avoid them. For more details on how erections work, continue reading this article.   Why Can't I Maintain an Erection? Top Erection Killers It is estimated that some degree of erectile dysfunction (ED) affects half of all men over the age of 40 and that 150 million men worldwide suffer from ED. There are many reasons a man might not be able to maintain a healthy erection, many of which play into our daily habits and lifestyle choices. If you are having trouble getting or maintaining an erection, consider testing for ED, as an imbalance of hormones could be the root of the problem. Many things that have the potential to hurt our general and sexual health are culturally acceptable so they simply never cross our minds. Low Testosterone: Testosterone plays a critical role in our sexual health and can be directly linked to libido. Not only do lower levels of testosterone equal lower sex drive, but also it can lead to venous leakage. This condition is characterized by the inability to “pinch off” emissary veins that carry blood away from the penis. This results in blood leaking out of the corpus cavernosum as quickly as it can be filled, making a lasting erection impossible to maintain. If you are having erectile difficulties, a simple testosterone test is a great first step on the road to treatment. Loss of Morning Erections: Morning erections, or the lack thereof, can be a good way to begin troubleshooting if you have psychological erectile dysfunction. The idea is that if you can achieve an erection by any means, nighttime or otherwise, then your issue is probably more mental than physical. Morning erections oxygenate erectile tissue and fight off penile fibrosis, keeping the penis elastic and healthy. High Blood Pressure: High blood pressure often results in hardening arteries, constricting blood vessels, and damage to the thin membrane that lines our hearts and veins. This restricts the amount of blood your body can readily provide to your penis when it is “go time.” Not only can high blood pressure kill an erection, but it can lead to a host of other, much more immediate, medical complications, including heart attack and stroke. Any Cardiovascular Risk Factor: Almost anything hard on the heart and cardiovascular system is going to lead to erectile dysfunction. The reason is simple: erectile dysfunction is strongly related to endothelial dysfunction, where the delicate lining of your arteries becomes damaged and does not output nitric oxide as it should. This is the primary reason that lifestyle is so critical: exercise, weight management, and diet all powerfully affect how your body carries blood and oxygen to your organs. Cholesterol Management: High cholesterol has been linked to erectile dysfunction due to its direct correlation with elevated LDL or “bad cholesterol.” LDL carries cholesterol to the arteries, which, when oxidized, damages artery walls. Contrary to HDL, which aids the body in eliminating excess cholesterol, elevated levels of LDL can significantly impact your heart, cardiovascular system, and ultimately, your erectile health. Bike Seats: Many standard bike seats can damage the pudendal nerve that is connected to the penis. If you have done a lot of bike riding recently and have erectile dysfunction, this is something to consider. The solution can be as simple as changing out your bike seat. Bisphenol-A and Phthalates: Our modern environment is filled with toxins that have been proven to damage the reproductive and sexual functions of animals, and as primates, men are no exception. Bisphenol A and phthalates are chemical compounds used in the production of polycarbonate plastics that litter our world today. These chemicals are filled with endocrine disruptors and xenoestrogens that, over time, can severely impact one’s hormonal and sexual health. Prolactin: Prolactin is a hormone that stimulates breast development and milk production in women; it serves no known normal function in men. However, high prolactin can decrease testosterone, lower libido, and cause sexual dysfunction. This is because high prolactin suppresses the secretion of gonadotropin-releasing hormone, which stimulates the production of testosterone in men and estrogen in women. Estradiol (E2): Estradiol is the primary form of estrogen during our reproductive years. In men receiving testosterone replacement therapy (TRT), the body can sense increasing levels of testosterone and aromatizes 0.4% of it to estradiol to compensate. Very high and low E2 in relation to testosterone levels can sabotage TRT results, leading to diminished libido. Testing for ED will give you a good idea of what hormones you have an excess or lack of. Excess Weight: Being overweight can lead to a plethora of health complications, including heart disease, high blood pressure, diabetes, and many more. Excess weight has also been proven to lower testosterone, increase estrogen, raise inflammation, and boost insulin levels. Together, these factors can significantly impact your sexual life. Smoking: Not just cigarette smoke, but any sort of burning inhalant is bound to damage your lungs and cardiovascular system. Smoke can also cause arteries to constrict and narrow, allowing less blood flow to the penis. Medications: Many, many medications will kill erections. Some lower testosterone. Some raise prolactin. Some have a sedating effect by raising serotonin levels. Some alter dopamine functions. The bottom line is that if you are on medication and having erectile difficulties, this is one of the first places that you should look. Depression: Depression is an acutely debilitating condition, not just mentally, but physically as well. Depression causes stress to the body, which, in turn, lowers testosterone. Depression also correlates with heart disease, as depressed individuals are less likely to be consistently physically active. Depression also elevates cortisol levels, which destroy neurons in the brain. All of these factors can lead to erectile dysfunction, which can often worsen depression. This bidirectional relationship reinforces the need to take care of one’s mind as well as body. Recreational Drugs: Many men do not realize that even something as relatively benign as marijuana use can affect their sex life. However, it has been proven to lower testosterone and damage the body’s cardiovascular system. Harder drugs, such as cocaine, heroin, ecstasy, or prescription painkillers, can have even more detrimental effects. They greatly increase one’s risk of developing heart disease, cause plaque buildup on artery walls, and severely reduce ejaculatory volume. In short, drugs age the body faster than normal, and that includes the penis. Consider carefully before indulging in your favorite recreational substances, as they can destroy gonad function, lower testosterone levels, and potentially lead to heart failure. Lack of Sleep: Not getting enough sleep at night can significantly lower testosterone levels, leading to erectile dysfunction. Ensure you get quality sleep to maintain sexual health. Watching TV in Bed: Spending too much time watching TV in bed can lead to a sedentary lifestyle, which negatively affects erectile function. Regular physical activity is crucial for maintaining sexual health. Watching Comedy Series: Engaging in light-hearted activities like watching a comedy series can reduce stress and improve overall well-being, which is beneficial for sexual health. Does More Testosterone Equal a Better Sex Life? As we’ve discussed, testosterone plays a critical role in stimulating sex drive and developing and maintaining erections. Low levels of testosterone have been directly linked to health conditions and dulled libido. However, this is not indicative of a simple “more is more” relationship between T and sexual health. Testosterone is a hormone that must be balanced properly, as an influx of it signals your body to increase the production of estradiol and prolactin. Watching too much TV, especially in bed, can lead to a sedentary lifestyle, which negatively impacts testosterone levels and erectile function. Make sure to closely monitor your T levels with a. To achieve ideal results, it is important to keep testosterone levels between 500 and 1000 ng/dL while ensuring your levels of estradiol and prolactin do not proportionately increase. It is not uncommon for certain prescription medications to interfere with TRT as well. Many antidepressants, blood pressure medications, and cholesterol-lowering agents have been known to dampen sex drive, even with the use of testosterone replacement. Finally (and most importantly), make sure you are attracted to the person you are intimate with. Lack of attraction to our sexual partners can be the biggest hurdle in achieving a strong erection. All the testosterone and lifestyle changes in the world won’t result in an erection if you simply don’t want to have sex with someone. Porn addiction has also been linked to ED, as it desensitizes us to nudity and intercourse. While there are many physical contributors to ED, there are unquestionably psychological elements as well. So before testing for erectile dysfunction, make sure that you are taking care of your body and mind while properly balancing the hormones your body needs for sexual activity. References   4 Causes of Erectile Dysfunction You Might Not Know 7 Factors That Can Affect Erections The Top Erection Killers Erectile Dysfunction Impotence (Erectile Dysfunction) Erectile Dysfunction (Impotence) Erectile Dysfunction 5 Common Erectile Dysfunction Causes Erectile Dysfunction: Symptoms and Causes Erectile Dysfunction: Symptoms and Causes Erectile Dysfunction (ED): Causes, Diagnosis & Treatment Medications Most Commonly Associated With Erectile Dysfunction: Evaluation of the Food and Drug Administration National Pharmacovigilance Database Erectile Dysfunction: Viagra and Other Oral Medications 5 Factors That Cause or Worsen Erectile Dysfunction (ED) Which Drug for Erectile Dysfunction? Drugs Linked to Erectile Dysfunction Erection Problems (Erectile Dysfunction)    

Pregnenolone for Men: An Overview of this Neurosteroid and Men’s Health Pregnenolone is a steroid hormone and natural steroid in the human body and has recently been in the spotlight in medical research, especially when it comes to men’s health. Low pregnenolone levels can cause muscle loss in aging men. This article will look into different studies that are looking into the role of pregnenolone, including the administration of pregnenolone for brain function, hormone balance, and how it can be used to treat schizophrenia. By looking into research papers, we will give you an overview of how pregnenolone affects men’s health. What is the neurosteroid pregnenolone? You could say pregnenolone is the “father” of all hormones! Your body makes hormones from cholesterol, the sterol lipid molecule made in our liver. But your body has to go through a process to make hormones like testosterone, estrogen, DHT, and so on. First it has to convert the cholesterol into pregnenolone, the mother of all hormones. From there it can make progesterone (where cortisol comes from) and DHEA (which is needed to make testosterone). This process is important because pregnenolone is a precursor to testicular steroid hormones, including testosterone, which are important for reproductive health and male sexual function. The synthesis of testicular steroid hormones happens in the mitochondria, where pregnenolone is produced and then converted into testosterone and other hormones. This process is important for overall hormonal balance and has big implications for reproductive health. But that first step (converting cholesterol into pregnenolone) is the most important step. Pregnenolone is the precursor to all these other hormones, as you can see in the chart below: In a young adult male, pregnenolone levels are at their peak. But as you age, the levels of this precursor hormone drop and the body’s response to it. At 75 years old, our body produces only 40% of the pregnenolone it needs. That’s a big drop in the precursor hormone, which means a big drop in all the hormones derived from pregnenolone. Before we get into the studies, let’s first understand what pregnenolone is and its basics. Pregnenolone is often referred to as a neurosteroid; it’s a precursor to many other steroids, including testosterone. It’s produced in the adrenal glands, brain, and gonads. This neurosteroid plays a big role in synaptic plasticity, cognitive function, and mood regulation. Definition and Biochemical Profile of Pregnenolone Pregnenolone is a naturally occurring steroid hormone in the human body produced primarily in the adrenal glands, brain, and gonads. It’s produced from cholesterol through the action of the enzyme cholesterol desmolase. This process converts cholesterol into pregnenolone, which then becomes a precursor to many other steroid hormones. Pregnenolone is lipophilic, meaning it can easily cross cell membranes, including the blood-brain barrier, so it can exert its effects all over the body. Its biochemical profile is characterized by its ability to be converted into other steroid hormones such as testosterone, progesterone, and cortisol through a series of enzyme-catalyzed reactions. This versatility is the reason why it’s important for many physiological functions. Role of Pregnenolone in the Body Pregnenolone plays a big role in many physiological processes, including stress response, mood regulation, and immune system modulation. As a precursor to other steroid hormones like testosterone, progesterone, and cortisol, pregnenolone is important for overall hormonal balance. As a neurosteroid, it’s especially important for cognitive health. Research has shown that pregnenolone can improve memory, protect against neural degeneration, and potentially improve focus and mental clarity. Pregnenolone also supports overall hormonal balance, which is important for overall health and well-being. By being a precursor to other steroid hormones, pregnenolone regulates many bodily functions, from stress response to reproductive health. Pregnenolone for Men: Supplementation Routes and Doses Pregnenolone can be administered orally, subcutaneously, intravenously, intranasally, topically, or transdermally. Oral pregnenolone has high metabolism and low bioavailability. It’s lipophilic and can cross the blood-brain barrier. There is very limited data on the pharmacokinetics of exogenous pregnenolone. When taken orally, allopregnanolone breaks down pregnenolone faster than other hormones made from pregnenolone substrates like cortisol or DHEA. One study showed that 3 hours after oral intake of 400 mg of pregnenolone, pregnenolone serum levels increased by 60%. 2 hours after that, allopregnanolone serum levels tripled. Another study showed that a single oral dose of 175 mg of pregnenolone doubled pregnenolone serum levels for 4-8 hours. One study by Marx et al. (2009) looked at the effects of exogenous pregnenolone in patients with schizophrenia or schizoaffective disorder. Participants were given 8 weeks of oral pregnenolone with an escalating fixed dose, 500 mg for the last 4 weeks. Pregnenolone and downstream metabolites were measured in the serum. Pregnenolone sulfate was 3x higher, allopregnanolone was 5x higher and serum pregnenolone was 4x higher when taken orally. Oral pregnenolone also increased progesterone in the blood by 4x and DHEAS by 16%. Exogenous pregnenolone did not increase serum testosterone, free testosterone, cortisol, DHEA, estradiol, or androstenedione. Pregnenolone and Allopregnanolone in Anxiety: Pregnenolone is a hormone in the human body and is the precursor to allopregnanolone. This is important because allopregnanolone regulates mood and emotional states through the central nervous system and the body’s stress response. Higher levels of allopregnanolone have been linked to reduced anxiety symptoms. This anxiolytic effect shows the hormone’s impact on mental health. Blocking or inhibiting allopregnanolone can have negative effects on social and affective functioning. So if allopregnanolone production or activity is slowed down, it can make it harder to interact with others and control your emotions. This is how important the hormone is for mental health and social well-being. Have you ever wondered how your brain handles emotions, especially during stress or anxiety? This has been a question for scientists for a long time. A recent study looked into the role of a neurosteroid called allopregnanolone in emotional regulation. This is a calming substance and has been linked to anxiety reduction. But how it affects our brain’s emotional control circuits has been a mystery until now. To better understand allopregnanolone’s role, researchers did an innovative experiment. They gave 400 mg of pregnenolone (a precursor to allopregnanolone) to 16 participants and a placebo to 15 others. The participants then did a brain scan (3T fMRI) while doing the Shifted-Attention Emotion Appraisal Task (SEAT). This task is designed to measure emotional processing and regulation. The results were interesting. Compared to the placebo group, the allopregnanolone group had reduced activity in two brain regions: the amygdala and the insula. These areas are responsible for generating negative emotions like fear and anxiety. Allopregnanolone made the dorsomedial prefrontal cortex work harder during the emotion judgment part of the task. This is the part of the brain that controls emotions. It also increased the connection between the amygdala and this region. This was correlated with lower self-reported anxiety in the participants. Pregnenolone in Schizophrenia Treatment Several studies have looked into the use of pregnenolone in schizophrenia, a mental disorder characterized by cognitive and mood disturbances. For example, Marx et al. (2014) did a randomized controlled trial to test the efficacy of pregnenolone in schizophrenia. They found some improvement in cognitive functions and symptom reduction. Marx et al. (2009) also looked into the effects of pregnenolone on cognitive and negative symptoms in schizophrenia. This proof-of-concept study confirmed the potential of pregnenolone in improving cognitive functions in schizophrenia patients. Ritsner (2010) gives a broader view of pregnenolone, dehydroepiandrosterone (DHEA), and their changes in schizophrenia. This study tells us a lot about the hormone changes in men with schizophrenia so the potential therapeutic role of pregnenolone is even clearer. Cognitive Function and Mood Enhancements Beyond schizophrenia, pregnenolone’s role in general cognitive health and mood improvement has been looked into, especially in relation to promoting deep sleep. Osuji et al. (2010) studied the effects of pregnenolone on cognition and mood in dual-diagnosis patients. Their study suggested the potential of pregnenolone to improve cognitive function and mood but only in a specific patient group. Hormonal Effects in Men The hormonal effects of pregnenolone, especially on testosterone and total testosterone, have been studied. Pregnenolone is converted into testosterone in the testes and changes in pregnenolone levels can affect overall reproductive health and male sexual function. In 2023, Bracci et al. looked into the changes in pregnenolone and testosterone in male shift workers. This study showed how work schedules can affect hormonal balance. Their results showed the importance of pregnenolone in maintaining hormonal balance for sexual health. Pregnenolone in Age-Related Hormonal Changes Morley (2013) reviewed the role of pregnenolone in age-related hormonal changes, specifically on rejuvenation and vitality. His overview of hormone treatments for rejuvenation mentions the importance of pregnenolone in maintaining hormonal balance as men age. Pregnenolone’s role in synaptic plasticity Synaptic plasticity is a term in neuroscience, the study of the brain and nervous system. To understand it, think of your brain as a network of roads, where each road is a connection between brain cells (neurons). These roads are called synapses. Think of these roads as changeable. Some can become wider or more used, making the travel (or communication) between brain cells faster and stronger. Others can become less used or even disappear. This changing nature of the roads (synapses) is what we call synaptic plasticity. This is like learning and memory in the brain. When you learn something new or remember something, the roads in your brain adjust. Some connections become stronger because you use them more (like practicing a skill), and others weaken because you use them less. So, synaptic plasticity is the brain’s ability to rewire itself based on experiences, learning, and memory. It’s why we can learn new things and remember them. This flexibility is important for our brain’s growth and adaptation throughout our lives. Smith et al. (2014) reviewed the role of pregnenolone in synaptic plasticity. Their study showed the role of neurosteroids in modulating synaptic plasticity, which has implications for cognitive functions and mental health. One of the important findings of Dr. Smith’s team was that pregnenolone helps brain cells communicate, especially in ways that are important for learning and remembering things. This communication happens through something called the N-methyl-D-aspartate receptor (NMDAR), which is like a tiny receiver on brain cells that helps them talk to each other. These scientists found that pregnenolone can move these NMDARs to where they’re needed on the brain cell surface. It does this with the help of calcium ions (tiny particles) and G-protein-coupled receptors. Also, pregnenolone can increase the levels of calcium inside brain cells, which is really important for strengthening brain cell connections. This strengthening is what helps us learn and remember things. Testosterone Replacement Therapy and Anabolics Decrease Upstream Hormones like Pregnenolone To fully understand pregnenolone’s effects, we also need to understand its relationship with testosterone and other steroid precursors. In 1985, Ruokonen et al. studied how serum testosterone and its precursor steroids responded to anabolic steroids and testosterone administration. This study gave us a basic idea of how pregnenolone works with other hormones. High doses of testosterone and anabolic steroids were used for 26 weeks by power athletes and then stopped for 16 weeks. During the 26 weeks of steroid use, SHBG and CBG in their blood changed. After 16 weeks of follow-up, serum testosterone and androstenedione increased (P < 0.05), but pregnenolone, 17-hydroxypregnenolone, dehydroepiandrosterone, 5-androstene-3 beta, 17 beta-diol, progesterone, and 17-hydroxyprogesterone decreased (P < 0.001). Pregnenolone, 17-hydroxypregnenolone, and dehydroepiandrosterone sulfate in the blood and free steroids changed, but 5-androstene-3 beta, 17 beta-diol, and testosterone sulfate remained the same during follow-up. During drug use, SHBG decreased by 80-90% and remained low for 16 weeks after steroid withdrawal. Steroids had no effect on serum CBG. In summary, taking testosterone and anabolic steroids by themselves messed up the testicular endocrine system. Low levels of testosterone precursors, a high ratio of testosterone to its precursor steroids and low SHBG were the indicators of this. Low levels of SHBG and testicular steroids were still present during the 16 weeks after drug withdrawal. If dehydroepiandrosterone and its sulfate are low in the blood, it means anabolic androgenic steroids also stop the adrenal glands from producing androgens. Pregnenolone Side Effects Now, as with any hormone, there are downsides to pregnenolone supplementation. Not everyone will experience side effects but most users report one or more of the following: Bloating—Many pregnenolone users have reported feeling bloated and puffy with regular use even when taken with DHEA or other steroid hormones. This may be because pregnenolone increases the production of ALL sex hormones, including estradiol (the precursor to estrogen). An increase in estrogen can cause water retention and bloating. High Estrogen Levels—As mentioned above, pregnenolone is converted into all sorts of sex hormones, including various forms of estradiol. This increase in estradiol can raise your estrogen levels. Weird Dreams—Many people taking pregnenolone have reported weird dreams after taking the supplement. While pregnenolone can reduce anxiety and stress (as above), it can make your brain overactive when you sleep and may cause weird dreams. Other Side Effects -- According to WebMD, "There isn't enough information to know if pregnenolone is safe when taken by mouth." However, it can cause effects similar to other steroid hormones: arrhythmia, hair loss, facial hair growth, headaches, mood changes, acne, anger, anxiety, irritability, and insomnia. For those with hormone-sensitive conditions (breast, ovarian, or uterine cancer, endometriosis), the hormone may exacerbate health problems since pregnenolone increases estrogen production. But the truth is, these side effects are really minimal. Pregnenolone is generally a safe supplement with limited side effects. Just be aware of what you're getting into when taking pregnenolone. Pregnenolone Safety and Side Effects Pregnenolone is generally safe but be aware of the side effects, especially with high doses or long-term use. Common side effects may include headaches, dizziness, and nausea. Consult with a healthcare provider before taking pregnenolone, especially if you're taking other medications or have underlying health conditions. Pregnenolone can interact with certain medications like hormone replacement therapy, blood thinners, or immune system modulators, which may alter their effectiveness or increase the risk of side effects. Getting proper medical guidance can minimize these risks and ensure safe and effective use of pregnenolone. How Much Pregnenolone Do You Need? If you're taking it to increase natural hormone production, you need to know HOW MUCH to take. You don't want to overdo it and end up with side effects! According to the Quest Diagnostics Manual: Men: 10 to 200 ng/dL Women: 10 to 230 ng/dL Children: 10 to 48 ng/dL Adolescent boys: 10 to 50 ng/dL Adolescent girls: 15 to 84 ng/dL Mean levels of pregnenolone don't differ significantly in postmenopausal women and elderly men (40 and 39 ng/dL, respectively). The typical dose of pregnenolone is 50 to 200 mg per day taken first thing in the morning. The pills are to be taken on an empty stomach or you can use a cream (transdermal application). But you may want to consult with your endocrinologist for professional medical advice before taking any pregnenolone. They may recommend a higher or lower dose depending on your pregnenolone levels or may advise against it, especially if you have underlying health conditions like cardiovascular diseases. Get a recommendation from a medical professional before taking any supplement, especially hormones like pregnenolone. BUY PREGNENOLONE TEST Questions About Pregnenolone for Men Does pregnenolone increase testosterone? Pregnenolone is a hormone that's a precursor to other hormones, including testosterone. While pregnenolone itself doesn't increase testosterone levels, it can play a role in the body's production of testosterone and other hormones. The effect of pregnenolone on testosterone levels may vary from person to person and depends on individual hormonal balance, overall health, and dosage. Consult with a healthcare provider or endocrinologist for personalized advice on hormone levels and supplementation. Does pregnenolone work for erectile dysfunction? Pregnenolone is a hormone that's being used as a supplement for various health conditions but has not been scientifically proven to treat erectile dysfunction. If you have erectile dysfunction, consult with a healthcare provider or a doctor who can give you options based on your individual health and situation. How does pregnenolone compare to other supplements men use for hormonal balance? Pregnenolone is a hormone that's a precursor to other hormones like testosterone, estrogen, and cortisol. When it comes to hormonal balance in men, pregnenolone has a unique role compared to other supplements used for this purpose. While supplements such as DHEA and testosterone boosters target specific hormones, pregnenolone serves as a building block for various other hormones in the body. This means pregnenolone can support overall hormonal balance by providing the raw material for hormone production. Consult with a healthcare provider before adding any new supplement to your regimen, especially when it comes to hormonal health. Where to buy Pregnenolone for Men? Pregnenolone for men can be found at health food stores, pharmacies, online supplement retailers, and some medical or wellness clinics. Make sure to buy from a reputable source to ensure quality and efficacy. Before starting any new supplement regimen, consult with a healthcare provider to determine the right dosage and if it's safe for your health needs. Buying Guide: What to Look For When choosing a pregnenolone supplement, consider the following factors to get a high-quality product. Look for supplements from reputable companies that have third-party testing for purity and potency. Check the dosage to match your individual needs and health goals. Also check the manufacturing standards of the product and opt for GMP. Consult with a healthcare provider before starting any supplement regimen, especially if you have underlying health conditions or are taking other medications. This will help you choose the right supplement and dosage for your needs. Research on pregnenolone shows its many roles in men's health, especially in cognitive function, mood regulation, and hormonal balance. While it shows promise in treating schizophrenia and improving cognitive and mood functions, more research is needed to fully understand its therapeutic potential and long-term effects. Buy your own pregnenolone test here. References Marx, Christine E. et al. “Proof-of-Concept Randomized Controlled Trial of Pregnenolone in Schizophrenia.” Psychopharmacology 231.17 (2014): 3647–3662. Bracci, Massimo et al. “Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers.” International journal of environmental research and public health 20.4 (2023): 3195-. MARX, Christine E et al. “Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia.” Neuropsychopharmacology (New York, N.Y.) 34.8 (2009): 1885–1903. Osuji, I. Julian et al. “Pregnenolone for Cognition and Mood in Dual Diagnosis Patients.” Psychiatry research 178.2 (2010): 309–312. Ritsner, Michael S. “Pregnenolone, Dehydroepiandrosterone, and Schizophrenia: Alterations and Clinical Trials.” CNS neuroscience & therapeutics 16.1 (2010): 32–44. Morley, John E. “Scientific Overview of Hormone Treatment Used for Rejuvenation.” Fertility and sterility 99.7 (2013): 1807–1813. Smith, Conor C., Terrell T. Gibbs, and David H. Farb. “Pregnenolone Sulfate as a Modulator of Synaptic Plasticity.” Psychopharmacology 231.17 (2014): 3537–3556.

Except for estradiol, no hormone is more misunderstood than dihydrotestosterone, or DHT. Many men fear DHT, going out of their way to use a DHT blocker for their medical condition. However, DHT is a critical hormone, one that men need for sexual and prostate health, cognitive function, skeletal strength, and many other reasons. Like everything in life, there are downsides to DHT, but the upside of healthy DHT levels far outweighs the challenges it can present. It is crucial to choose a DHT blocker that has support from scientific research in order to ensure both safety and efficacy when considering its use for hair thickness and general health care. In the intricate world of hormones and their impact on men's health, Dihydrotestosterone (DHT) often emerges as a topic of considerable debate and intrigue. This potent androgen, frequently overshadowed by its more famous counterpart testosterone, plays a pivotal role in numerous physiological processes yet is often misunderstood or feared due to its association with certain medical conditions. Our journey in this article is to demystify DHT, unraveling its complexities to reveal not just the concerns it raises but, more importantly, the indispensable benefits it offers for male health. From sexual wellness to cognitive abilities and skeletal integrity, DHT's influence is far-reaching, making it essential to understand and appreciate its role in the broader context of hormonal balance and overall health. DHT – FRIEND OR ENEMY? Except for estradiol, no hormone is more misunderstood than dihydrotestosterone, or DHT. Many men fear DHT, going out of their way to lower it and frustrate its biological activity. However, DHT is a critical hormone, one that men need for sexual and prostate growth, cognitive function, skeletal strength, and many other reasons, such as hormonal health conditions. Like everything in life, DHT has downsides, but the upside of healthy DHT levels far outweighs the challenges it can present. DHT, the main hormone involved in male-pattern hair loss, can attach to receptors in your scalp and damage your hair follicles, leading to a receding hairline, hair thinning, and even severe hair loss. DHT – Where it Comes From The principal hormone produced in men is, of course, testosterone. When testosterone is produced by the testicles (or injected or absorbed by a man on testosterone replacement), an enzyme, 5-alpha reductase(5-AR), sets to work, converting a portion of that testosterone to DHT, which is the conversion of testosterone into the androgen hormone dihydrotestosterone (DHT). This conversion prevents some testosterone from reaching the androgen receptors in the brain, genitals, skin, and other tissues. Initially, that may sound like the body is deprived of a needed hormone, testosterone. However, for the most part, this conversion is actually in a man’s best interest. Though estimates vary, DHT binds much more efficiently to androgen receptors; DHT is 300 to 500 percent more efficient at reaching and binding to the receptors and is far more potent than testosterone. If tissues were deprived of DHT, 5-AR hadn’t done its job; there would be dramatic physiological changes. While it is true that testosterone remains the primary, active androgen in muscle and muscle development, DHT is still critical for testosterone's full performance-enhancing effects. Specifically, the impact of DHT on the central nervous system increases neurological efficiency and strength. The production of body hair DHT comes from testosterone, with the help of the enzyme 5-alpha reductase (5-AR). The production of DHT is a natural process that occurs when testosterone is converted into the androgen hormone dihydrotestosterone (DHT) with the help of the enzyme 5-alpha reductase (5-AR). DHT – Positive Effects  To understand DHT’s androgenic properties, consider the following. Male Development – Physical and sexual development in the human male is DHT-dependent. DHT is responsible for the growth and development of the penis, the prostate, and the testicles. It not only helps with sex differentiation during fetal development but also supports the changes that occur during puberty and adulthood. Libido – DHT supports a healthy sex drive. Men with optimal levels of the hormone report a far stronger drive than men with lower levels. Prostate Health – Men with balanced levels of DHT may have fewer prostate health issues. Cognitive Function – One study indicated that administering DHT to men between 34 and 70 resulted in memory improvements. The androgenic properties of the hormone encouraged the retrieval of stored memories and the archiving of new ones. Low/lower levels of DHT were linked to a decline in cognitive function in elderly men. Blood Sugar Management – Higher levels of DHT help to reduce the risk of diabetes by controlling sugar levels and preventing hyperglycemia. DHT can improve insulin sensitivity, support efforts to lose weight, and may provide adjunctive support in treating diabetes.  Cardiovascular Health – Men with coronary artery disease may benefit from higher levels of DHT since lower hormone levels have been shown to increase the risk of cardiovascular disease. It may be a simple association – higher levels of DHT might lower the mortality associated with heart disease. Stroke Risk – Researchers followed a group of men for six years and learned that higher levels of DHT and testosterone seemed to lower the risk of stroke.  Depression – In one study, men who used finasteride, a drug that blocks 5-AR and, thus, generates lower levels of DHT, had higher rates of depression than a control group. DHT may well be necessary to support mental and emotional health. Anti-Aging – Higher levels of DHT, testosterone, and estradiol seem to slow the decline associated with aging. Lower levels of all three hormones brought about cellular changes seen in the elderly. Higher levels were associated with “younger” cellular function. Bone and Skeletal Health – Along with estradiol, appropriate levels of DHT support and maintain bone density in men. DHT – The Downside The DHT story is firm but not universally positive. The drawbacks of DHT must be considered. Baldness – Hair loss is probably the number one DHT—harmful in the minds of most men who are involved in testosterone therapy. Studies have shown that higher levels of DHT are linked to increased male-pattern baldness. In women, elevated levels of DHT can lead to male-like hair growth patterns. Cancer – DHT is critical for the normal development of the prostate, but high hormone levels have been associated with prostate cancer risk. However, studies on DHT and prostate cancer are contradictory. Acne – Inflammatory acne flares have been linked to DHT.  DHT – The Bottom Line: A Friend or Foe? For men, DHT is a friend and an important one. However, like virtually every hormone in the body, the key to health is balance. If DHT levels drop too far, men open themselves to low libido.  DHT is not likely to be tested in most men undergoing testosterone replacement therapy. Some clinicians fail to recognize the importance of DHT for men’s health and libido, so they fail to monitor it. It’s entirely possible, even likely, that some men are not obtaining the maximum benefits of testosterone replacement because (unbeknownst to them) their DHT levels are not optimal.  DiscountedLabs.com offers a highly affordable DHT test to help you determine if your body is producing sufficient DHT. The DHT test is quick, easy to administer, and reliable.   How to Increase DHT There are natural ways to boost DHT levels if one is not on a testosterone replacement protocol. Here are a few things that can be done. Exercise more, particularly resistance training and high-intensity training. Increase your intake of caffeine, creatine, or green tea supplements. Boost the amount of zinc in your diet via the food you eat or a supplement. Take a DHEA supplement if your DHEA blood level is low. Get a DHEA blood test Lose weight. Optimize your testosterone blood level, which is low. Last but not least, use a scrotal testosterone cream. Applying compounded (alcohol-free) testosterone cream to the testicular skin has increased DHT considerably. Using a DHT Blocker to Lower DHT It should be clear that most men have no reason to suppress their DHT levels. However, Propecia is regularly prescribed as a DHT blocker for men anxious about losing their hair, specifically to address male pattern baldness (a.k.a. androgenic alopecia). As was noted, Propecia will stop or suppress the 5-AR activity that produces DHT, thereby reducing DHT production. By blocking or slowing the work of 5-AR, one of the possible adverse side effects that DHT can have, male pattern baldness, may be prevented or arrested. Unfortunately, there is scientific evidence that some men who take this medication may risk lowering their libido and mood. In many cases, using DHT blockers like finasteride can help you to slow down or stop androgenic hair loss and even stimulate growth, allowing people to slow down or prevent hair loss and maintain a full head of thicker, healthier hair well into their 40s, 50s, and 60s. Topical finasteride is not FDA-approved yet but has shown promise in clinical studies. It can be sold by compounding pharmacies with a prescription. For reasons still not clearly understood, this medication can produce a syndrome in some men very similar to those symptoms associated with hypogonadism. Loss of libido, weak erections, malaise, and fatigue plague many men even after they have stopped using the drug. While it’s true that no one wants to lose their hair, no man wants to wind up with what has come to be known as post-finasteride syndrome. With proper attention, DHT can be a friend and ally in the search for optimal health. Don’t fear it; accept it and have it work to your advantage. Conclusion Navigating the intricate landscape of DHT and its role in men's health requires a nuanced understanding that balances the pros and cons. While concerns like male pattern baldness and potential links to certain health issues cannot be overlooked, the substantial benefits of DHT in areas like sexual health, cognitive function, and metabolic regulation highlight its critical role. The key lies in achieving hormonal equilibrium and ensuring that DHT levels are maintained within an optimal range. For those considering testosterone replacement therapy or DHT blockers, it's crucial to make informed decisions based on a comprehensive understanding of DHT's impact and the latest scientific research. At DiscountedLabs.com, we offer affordable and reliable DHT testing, empowering you to make the best choices for your health and wellbeing. Remember, DHT is not just a hormone to be managed but a vital component of a balanced and healthy male physiology.   Buy Your DHT TEST on DiscountedLabs.com  

Vitamin D and testosterone are two of the most important factors in our health but are often overlooked. This post will dive into the complex relationship between vitamin D and testosterone, looking at how deficiency affects our health and the results of The Graz Vitamin-D Randomized Clinical Trial on hormonal balance through a randomized controlled trial. We’ll look at several studies that have investigated the correlation between 25(OH)D deficiency and sex hormones. And we’ll see how vitamin D supplementation can affect hormonal balance by looking at the results of The Graz Vitamin-D Randomized Clinical Trial. We’ll also look at how much testosterone the testicular tissue can produce with different amounts of vitamin D and how blood levels of testosterone and vitamin D are related. And we’ll touch on symptoms of low testosterone and why it’s important to understand your Vitamin D status & hormonal balance for optimal health. Introduction and Background on Vitamin D and Testosterone Vitamin D and testosterone are two of the most important nutrients in our bodies and overall health. Vitamin D is a fat soluble vitamin that is important for bone health, immune function and reproductive health. It regulates calcium and phosphate metabolism so bones stay strong and healthy. Testosterone is a steroid hormone produced in the testes in men. It’s responsible for male characteristics like facial hair, deep voice and muscle mass. Research shows a complex relationship between vitamin D and testosterone in men. Studies show that vitamin D deficiency is linked to low testosterone which can cause various health issues. Understanding this relationship is important for optimal health outcomes especially for men who are experiencing symptoms of low testosterone. What is Vitamin D’s Role in the Body Vitamin D is an essential nutrient that plays a big role in bone health, immune function and reproductive health. It regulates calcium and phosphate metabolism which are needed for strong bones and teeth. Vitamin D also supports the immune system to fight off infections and diseases. We get vitamin D from sun exposure, diet and supplements. But many are deficient in vitamin D especially during winter when sun is scarce. Deficiency can cause various health problems like weak bones, increased susceptibility to infections and impaired immune function. Having adequate vitamin D levels is important for overall health and well-being. Low Testosterone and Vitamin D Deficiency Obesity is linked to low serum 25-hydroxyvitamin D (25(OH)D) levels which in turn is associated with testosterone deficiency and low testosterone in young men. Hypovitaminosis of vitamin D can cause long term health problems like drop in testosterone production and higher risk of hypogonadism. In this section we’ll discuss what causes low testosterone and lack of vitamin D and how these two affects each other. Causes of Low Testosterone and Vitamin D Deficiency Poor diet: A diet lacking in essential nutrients like vitamin-D rich foods such as fatty fish, fortified dairy products and egg yolks can cause deficiency. Those deficient in vitamin D may benefit from taking the right vitamin D supplement to address low testosterone. Lack of sun exposure: Since our bodies synthesize vitamin D through sun exposure on our skin, not spending enough time outdoors or living at higher latitudes can cause deficiency. Obesity: Excess body fat can disrupt hormone regulation and absorption/utilization of vitamins like vitamin D (source). This creates a vicious cycle where obesity causes low testosterone and worsen existing deficiency. Aging: As men age, their natural ability to produce hormones like testosterone decreases. Older adults have lower 25(OH)D levels partly because they spend less time outdoors exposed to direct sunlight (source). How Low Testosterone and Vitamin D Deficiency Affects Health The interplay of low testosterone and vitamin D deficiency can cause: Hypogonadism: A condition where the testes produce less or no hormones leading to symptoms like fatigue, decreased muscle mass and sexual dysfunction. Osteoporosis: Both testosterone and vitamin D are important for bone density. Low levels of either nutrient can increase risk of osteoporosis (source). Mood disorders: Studies show that there is a link between low testosterone/vitamin D deficiency and higher prevalence of depression and anxiety (source). Cardiovascular disease: Research shows that men with lower levels of both hormones are at higher risk of cardiovascular events like heart attacks or strokes (source). Given these health effects, it’s more important to know how obesity affects this interaction and how to balance our hormones as a whole. Low testosterone and not enough vitamin D go together to create health problems so it’s clear there’s a strong connection between the two. We need to look into the studies on how vitamin D affects serum testosterone levels to understand more about these associations. Summary: This article discusses the connection between low testosterone and vitamin D deficiency and their health effects. It’s clear that obesity plays a big role in the hormone relationship so understanding how these two work together is key to overall health. Vitamin D and Testosterone Levels Research In the recent years, many studies have been done to look into the relationship between vitamin D status and hormone balance especially on free bioavailable testosterone levels and testosterone production. Some studies show positive association between 25(OH)D levels and total/free testosterone levels while others found no significant relationship for certain hormonal parameters. Studies on 25(OH)D deficiency and sex hormones A study in Clinical Endocrinology (Oxf) found that men with sufficient vitamin D had higher total testosterone (TT), free testosterone (FT) and bioavailable testosterone compared to those with insufficient or deficient vitamin D. The researchers concluded that there is a strong relationship between 25(OH)D and TT/FT levels. A study in The Journal of Clinical Endocrinology & Metabolism found that low 25(OH)D was associated with hypogonadism in middle aged men but not with changes in luteinizing hormone (LH). A more recent study in Andrology however found no significant correlation between 25(OH)D levels and various hormonal parameters like LH, FSH and inhibin B in healthy young men. The studies show the complex relationship between vitamin D and testosterone production. We need to consider that age, ethnicity, BMI and overall health can affect 25(OH)D levels and hormonal balance in men. A strong connection between 25(OH)D deficiency and sex hormones has been shown in Vitamin D and testosterone studies where testosterone levels were measured in nmol/L. We will now look into the effect of vitamin D supplementation on hormonal balance by examining the results of the Graz Vitamin D Randomized Clinical Trial. Vitamin-D Supplementation and Hormonal Balance One of the studies that looked into the relationship between vitamin D supplementation and hormonal balance is the Graz Vitamin-D Randomized Clinical Trial. The objective of this study was to compare the effects of taking vitamin D for 12 weeks to taking a placebo. The study showed significant differences between the vitamin D group and the placebo group in insulin resistance, hormone levels and other metabolic parameters. Some of the findings on how vitamin D affects testosterone and other metabolic parameters were quite interesting. Graz Vitamin-D Randomized Clinical Trial Results Improved Metabolic Parameters: Those who took vitamin D supplements had reduced insulin resistance which is key to overall health and preventing chronic diseases like type 2 diabetes. Influence on Estradiol Levels: The supplemented group had increased estradiol levels which is one of the main female sex hormones. The supplemented group’s increase in estradiol levels was not statistically significant compared to the placebo group. No Significant Effect on Total Testosterone (TT) Levels: Surprisingly, there was no difference in TT levels between those who took vitamin D supplements and those who did not. This means that while there may be a relationship between blood testosterone levels and vitamin D, supplementation may not have a significant impact on hormone production or regulation for everyone. This study shows the complexity of hormonal balance in our body. Although it’s clear that getting the right nutrients like vitamin D is important for overall health, more research is needed to understand how they affect testosterone production. Those who want to optimize their hormone levels through diet or supplements should consult a healthcare professional and stay updated with the latest research. The Graz Vitamin-D Randomized Clinical Trial results showed that taking vitamin D supplementation had a positive effect on hormonal balance. More research is needed to find out how hCG injections will affect men with different vitamin D levels and how there is a link between testosterone and vitamin D. More well-designed randomized controlled trials are needed to clarify these relationships. Conclusion: So vitamin D supplementation may not affect testosterone levels but it seems to affect metabolic parameters and estradiol levels. More research is needed on how nutrients like vitamin D can alter or control hormone production so consult a specialist before starting any diet or supplementation program. Testosterone and Vitamin-D A study from Rigshospitalet found a relationship between testosterone, sex hormone-binding globulin (SHBG) and vitamin D in 300 healthy men with normal testosterone production. This shows the importance of having adequate vitamin D for hormonal balance. Vitamin-D and Testicular Tissue’s Ability to Produce Testosterone Vitamin D is involved in many physiological processes including sex steroid production. In testicular tissue, it was found that low vitamin D can impair the ability to produce testosterone. Men with low vitamin D had less response to hCG injections compared to those with normal or high vitamin D levels. The studies included in this review were selected based on strict inclusion and exclusion criteria to ensure the integrity and quality of the review process. hCG Injections on Men With Different Vitamin-D Levels Serum Levels: Those with higher 25(OH)D serum levels had increased total testosterone after hCG injections compared to those with lower 25(OH)D serum levels. Luteinizing Hormone (LH): Response rate was also seen for luteinizing hormone which is responsible for stimulating testosterone production in the testicles. Follicle-Stimulating Hormone (FSH): No significant difference was seen in FSH response between the groups based on their initial 25(OH)D levels. So there may be a link between testosterone and vitamin D but more research is needed to understand the implications. For overall health and wellness men should have healthy levels of both hormones. Vitamin D is involved in testosterone production and regulation so let’s think about what this hormonal balance means to a person’s overall health. Conclusion: The study showed a positive correlation between testosterone and vitamin D, higher 25(OH)D resulted to higher total testosterone, LH response was also better when 25(OH)D was normal or high. The study suggests there may be a link between the two which is important for men’s health. Testosterone Production, Regulation and Health Testosterone deficiency which has many health implications is produced in the testes and regulated by hormones like LH. It’s produced in the testicles and regulated by pituitary hormones like luteinizing hormone (LH). Low testosterone can have many negative effects on overall health. In this section we will discuss some of the common symptoms of low testosterone and why we need to understand Vitamin D status & hormonal balance. Symptoms of Low Testosterone Fatigue: One of the most obvious symptoms of low testosterone is fatigue or lack of energy. Men may find it hard to be active or finish their daily tasks due to low energy. Muscle loss: Testosterone is involved in muscle mass so deficiency leads to loss of muscle strength and size. Low libido: Decrease in libido or sex drive often accompanies low testosterone. This may also result to erectile dysfunction in men. Bone problems: Testosterone regulates bone density so deficiency can increase risk of osteoporosis and fractures. Mood changes: Men with low testosterone may experience mood swings, irritability, depression or anxiety as their hormonal balance gets disrupted. li> Why We Need To Understand Vitamin-D Status & Hormonal Balance Vitamin D affects many physiological processes in our body including sex hormones like testosterone. As mentioned earlier studies showed a link between blood testosterone and vitamin D in healthy men with normal testosterone production. So maintaining optimal vitamin D levels may be important for hormonal balance. But more research is needed to understand how these two work together in the body’s endocrine system. In the meantime men who are experiencing symptoms of low testosterone should consult their doctor for proper diagnosis and treatment that can improve both hormone levels and overall health. Conclusion: This article discusses the link between Vitamin D and testosterone, the implications for men who are experiencing low energy or muscle loss. It discusses the common symptoms of low testosterone like low energy and muscle loss, bone problems and mood changes. And how maintaining optimal vitamin D levels can help preserve hormonal balance in men experiencing these symptoms. Vitamin D and Testosterone in Women Vitamin D and testosterone are often linked to men’s health but they also play a big role in women’s health. Vitamin D is important for bone health and immune function in women. It is also involved in the regulation of reproductive hormones for proper menstrual cycles and fertility. Testosterone although present in smaller amounts in women is involved in the development of female characteristics like libido and muscle mass. Having adequate levels of both vitamin D and testosterone is important for women’s overall health. Vitamin D deficiency can cause many health problems like osteoporosis, autoimmune diseases and certain cancers. Low testosterone can affect libido, muscle mass and overall energy. Understanding the roles of these nutrients in women’s health is important to prevent and manage these conditions. Why Vitamin D is important for Women’s Health Vitamin D is important for bone health and immune function in women. It regulates calcium and phosphate metabolism so bones are strong and healthy. It also supports the immune system to fight off infections and diseases. It is also involved in the regulation of reproductive hormones for proper menstrual cycles and fertility. Vitamin D deficiency has been linked to many health problems in women like osteoporosis, autoimmune diseases and certain cancers. Having adequate vitamin D is important to prevent these conditions and overall health. Women should get enough vitamin D through sunlight, dietary sources and supplements if needed. Regular check-ups and blood tests can monitor vitamin D levels and ensure optimal health. FAQs about Vitamin D and Testosterone Does vitamin D increase testosterone? There is some evidence that vitamin D may have a positive effect on testosterone. Studies show that taking vitamin D supplements can increase testosterone especially in men who are deficient. But more studies are needed to determine the ideal dosage and if other factors affect this relationship. To get the most out of vitamin D supplements for testosterone, you should also change your lifestyle like exercise more and eat better. How much vitamin D for testosterone? Vitamin D is important for testosterone production. Studies show that men with higher vitamin D levels have higher testosterone than those with lower levels. For optimal testosterone production daily vitamin D intake should be between 600-1000 IU but higher doses may be needed in some cases. If you are unsure of your current vitamin D status or how much to supplement, consult a doctor before taking any supplements. Conclusion In summary, we need to understand the connection between vitamin D and testosterone. Low levels of either can cause health problems like low energy or libido, depression and even increase risk of certain diseases. To keep you healthy you should eat a balanced diet with vitamin D rich foods (like fish) and exercise regularly. Supplement may be needed if your blood tests show you have low levels of these nutrients. Proper care can provide our body with the necessary vitamin D and testosterone for optimal health. Check your Vitamin D and Testosterone levels with Discounted Labs. Get your Vitamin D and Testosterone test today without doctor’s visit!   References Effect of Vitamin D Supplementation on Testosterone Levels in Men Association Between Vitamin D Deficiency and Testosterone Levels in Adult Males: A Systematic Review Can Vitamin D Restore Low Testosterone Levels? Vitamin D Increases Testosterone Production Can Vitamin D Increase Testosterone Concentrations in Men? 25-Hydroxyvitamin D and Testosterone Levels Association Through Body Mass Index: A Cross-Sectional Study of Young Men with Obesity Effect of Vitamin D Supplementation on Testosterone Levels in Men  

How to Safely Use PCT After TRT: Stopping Testosterone Replacement Therapy Table of Contents What is Post Cycle Therapy PCT? Why Do Men Stop TRT? Common reasons a man may need to discontinue TRT include: Normalizing Natural Testosterone After Stopping TRT PCT Treatments to Jump Start Natural Testosterone and Sperm Production How to Know if Your PCT Worked? Buy Discounted Lab's Post-PCT Panel  References: There is a common phrase most men will hear when they consider testosterone replacement therapy (TRT); it may be something they hear from friends or often what they read online: "TRT is for life." There is an element of truth to this statement: when a man has low testosterone, in order to treat it and maintain healthy or optimal levels, he will always need TRT to achieve it. However, saying "it's for life" remains a somewhat inaccurate statement, and this is where we enter into the realm of what is commonly referred to as Post Cycle Therapy or PCT. TRT and anabolic androgenic steroids (AAS) can lead to dysfunction in HPTA (Hypothalamic-Pituitary-Testicular Axis). Supplemental testosterone can inhibit the release of the body's own testosterone production through negative feedback inhibition on LH levels. This feedback inhibition also results in the suppression of FSH levels, leading to the suppression of sperm production (spermatogenesis). During recent years a large surge in testosterone prescriptions and TRT clinics has unfortunately led to many men who have been misdiagnosed with low testosterone yet placed on TRT when it may not have been needed in the first place. If you are one of these men and you are considering discontinuing testosterone treatments, some protocols can help restore your hormone axis. You do not want to stop testosterone "cold turkey," which will lead to unnecessary symptoms that could last for many months. Understanding TRT and Its Impact on the Body Testosterone Replacement Therapy (TRT) can be a game-changer for men with low testosterone levels, but it's crucial to understand how it impacts the body. TRT involves introducing exogenous testosterone into the body, which can disrupt the natural hormone production process. To grasp the full picture, we need to explore the Hypothalamic-Pituitary-Testicular Axis (HPTA) and how TRT affects it. The Hypothalamic-Pituitary-Testicular Axis and TRT The Hypothalamic-Pituitary-Testicular Axis (HPTA) is a sophisticated system that regulates testosterone production. It starts with the hypothalamus, which produces Gonadotropin-Releasing Hormone (GnRH). This hormone signals the pituitary gland to release Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). LH and FSH then stimulate the testes to produce testosterone. When you undergo Testosterone Replacement Therapy (TRT), this delicate balance can be disrupted. The introduction of exogenous testosterone can suppress the body's natural production of LH and FSH, leading to a decrease in the body's ability to produce testosterone on its own. Impact of TRT on Natural Testosterone Production The impact of TRT on natural testosterone production can be significant. When exogenous testosterone is introduced, it can lead to a suppression of LH and FSH, which are crucial for natural testosterone production. This suppression can result in various symptoms, such as low libido, fatigue, and decreased muscle mass. Over time, prolonged use of TRT can lead to hypogonadism, a condition where the testes are unable to produce sufficient testosterone. This is why understanding the effects of TRT on natural hormone production is essential for anyone considering or currently undergoing TRT. What is Post Cycle Therapy PCT? PCT is a treatment plan after discontinuing anabolic androgenic steroids (AAS). It is a phrase most commonly associated with what we might call "recreational steroid users" (RSU), such as bodybuilders: people who do not need steroid hormones like testosterone for medical reasons but use them for muscular competition advantage. In such cases, the individual will supplement with AAS for a set period of time, known as a steroid cycle, and then discontinue use. As his use of AAS shut down his natural testosterone production, just as it does with TRT, he will often implement a PCT plan for natural production to restart. Such plans will include Selective Estrogen Receptor Modulators (SERMs) or other items, such as the peptide HCG. The goal for the RSU, as eluded to prior, is to regain his natural production of testosterone as quickly and efficiently as possible. There is no guarantee this will work. There is no guarantee he will reach his previous levels before AAS use, although perhaps levels that accurate enough. Then we have the TRT patient; such an individual had low testosterone levels before he began administering exogenous testosterone. The use of testosterone, just as it did with the RSU, will stop his natural production. This is a factor that bothers many men, but let us keep in mind a very significant one: you already had low levels, your body was not able to produce enough, to begin with, and was not going to be able to, or you wouldn't be on TRT. Nonetheless, there are reasons some men may find they need to discontinue use, and when that occurs, a PCT plan may be in order. Such a plan will not address his primary issue, low testosterone, but the goal here is to get at least some natural production back online. Why Do Men Stop Testosterone Replacement Therapy? Common reasons a man may need to discontinue TRT include: Need for Fertility TRT Cost TRT Side Effects or Health Issues Of the three potential reasons to stop TRT, fertility is the overwhelming reason for most men. Along with suppressing natural testosterone production, TRT can also have a negative impact on sperm production. There was a time in history not that long ago when it was thought exogenous testosterone would be touted as a male contraceptive. This idea died out when many men using testosterone found they were still able to impregnate a female. While many men on testosterone were found to be severely lacking in this department, it wasn't enough or significant enough to market the hormone as an actual contraceptive. The other common reasons for discontinuing TRT are cost and side effects. These are the least common reasons in comparison to fertility needs or desires, but both are still possible. We all go through points in life where money can get a little tight; loss of a job, unexpected expenses – whatever the reason, if you find you need to stop, considering a PCT plan with your physician will make the transition easier. You're still going to have low testosterone levels in the end – remember, you already had them, or you wouldn't have started TRT in the first place – but you'll hopefully be in a better position than you would be without, and in time, when your situation improves, you'll be able to jump back on your TRT plan. The same may hold true for the individual who has side effect issues. This will be the least common reason for discontinuation of TRT but certainly within the realm of possibility. You could be one of the rare individuals who cannot control his hematocrit even with regular therapeutic phlebotomy. You could be someone that has other health concerns and, for whatever reason, need to discontinue use until you figure out what's going on with your body. Hormonal imbalances, such as elevated estrogen levels, can also occur when stopping TRT, leading to conditions like gynecomastia. As was with the individual who was experiencing income issues, a PCT plan may be in order. Preparing for TRT Discontinuation Deciding to discontinue TRT is a significant step and should be approached with caution. One of the most critical aspects of stopping TRT safely is to do so under the guidance of a medical professional. Abruptly stopping TRT can lead to severe withdrawal symptoms and a dramatic drop in testosterone levels, which can be detrimental to your health. Gradual Tapering Under Medical Supervision When it comes to discontinuing TRT, gradual tapering is the safest approach. This process involves slowly reducing the dosage and frequency of testosterone administration to allow the body to adjust and begin producing testosterone naturally again. A healthcare provider can create a personalized tapering schedule based on factors such as the dosage and duration of your TRT use. This might involve reducing the amount of testosterone you inject or apply through gels over a set period. Regular check-ups with your healthcare provider are crucial during this time to monitor your progress and make any necessary adjustments to your tapering plan. This careful and monitored approach helps minimize withdrawal symptoms and supports the body's natural transition back to producing testosterone on its own. By understanding the impact of TRT on your body and following a medically supervised tapering plan, you can safely discontinue TRT and support your body's return to natural testosterone production. Normalizing Natural Testosterone After Stopping TRT For most men, studies have shown that for men who stop TRT, natural testosterone production can normalize within three months or longer, and spermiogenesis in well over a year. This is certainly not optimal when conception is the goal, which leads to the possible need for a PCT protocol. Post cycle therapy (PCT) is crucial in maintaining and recovering natural testosterone levels after using performance-enhancing drugs, as it helps enhance the body's own testosterone production. PCT Treatments to Restore Hormonal Balance and Jump Start Natural Testosterone and Sperm Production The use of the SERMs has been shown to increase testosterone levels to baseline in as little as 2-4 weeks. Studies have also shown spermiogenesis to improve significantly within 3-6 months. Clomid as we can easily see, greatly improves the time frames of recovery of these two important factors related to conceiving (testosterone and semen). PCT is crucial to restore hormonal balance, helping individuals recover from the use of anabolic steroids by promoting natural testosterone production and mitigating adverse effects caused by hormonal imbalances. HCG is another item commonly used in PCT for fertility purposes. HCG PCT has the ability to stimulate both testosterone production and spermiogenesis. It is not uncommon for fertility specialists to try both Clomid and HCG and, in some cases, in conjunction with one another. Unfortunately, there is much controversy among many fertility specialists regarding how much HCG should be administered for this purpose. While many physicians will prescribe SERMs in the range of 25-50mg per day to every other day, commonly prescribed HCG doses can run anywhere from 1000iu per day to 2500iu or even larger doses split into every other day schedules. Other common drugs used in this treatment, but to a lesser extent, include the SERM Tamoxifen Citrate, best known by its most notable trade name, Nolvadex. Treatments usually requires 4 weeks. Unfortunately, for some men, a PCT plan that includes some or all of these medications will not work. A HCG PCT plan is most likely to work in a TRT patient who is receiving treatment due to secondary hypogonadism. If a PCT plan has not worked – testosterone levels and sperm count have not increased – it is likely that the individual has primary hypogonadism, and as a result, will be best served (quality of life) by remaining on TRT. It's imperative to note: this individual had primary hypogonadism prior to beginning TRT, he did not obtain it because of TRT. How to Know if Your PCT Worked? After going through PCT, physicians tend to check your testosterone blood levels and upstream hormones like LH and FSH to determine if your hormone axis has been restored. Discounted Labs has created a Post PCT Lab Test Panel that makes it easy for men to know if their PCT has successfully worked. This lab test panel is designed to measure the health and recovery of the Hypothalamic-Pituitary-Testicular Axis (HPTA) after attempting to normalize it spontaneously or with the use of Post Cycle Therapy (PCT) (with the use of clomiphene, hCG, and other treatments) It is suggested that this panel be done no sooner than 4 weeks after PCT cessation and in a fasting state. You should fast for 12 hours before collection of the specimen. Fasting is defined as no consumption of food or beverage other than water for at least 12 hours before testing. If using a testosterone cream please be sure you have not rubbed any into the antecubital area of your arm for the last 24 hours as it can give elevated results. Lab tests included in the post-PCTest Panel: Ultra Sensitive Estradiol Test by Liquid Chromatography/Mass Spectrometry (LC/MS assay used to measure estradiol in men more accurately estradiol in men) Total and Free Testosterone LC/MS- No upper limit Luteinizing Hormone (LH) (responsible for activating Leydig testicular cells to produce your own testosterone). This hormone is shut down by testosterone replacement or AAS. Follicle Stimulating Hormone (FSH) (Responsible for activating Sertoli testicular cells to produce sperm). This hormone is shut down by testosterone replacement or AAS. CBC - Complete Blood Count (Includes hematocrit- red blood cell volume) CMP - Comprehensive Metabolic Panel (Includes liver and kidney function, glucose and electrolytes) For any man, simply discontinuing the use of testosterone can be difficult, to put it mildly. Your testosterone levels will completely bottom out when going the cold-turkey route, and this often. This severe sexual dysfunction, decreased energy, and even depression, to name a few of the consequences. Your levels may go up enough to at least function, to a degree, but it's going to take an enormous amount of time, as previously discussed. Cutting this time down significantly, and giving your body a boost in testosterone during the therapy process, is the only means of discontinuation that makes any sense, meaning some form of a PCT plan is a sensible approach. Buy Discounted Lab's Post-PCT Panel  References: Diagnosis and Management of Anabolic Androgenic Steroid Use Testosterone Use in the Male Infertility Population: Prescribing Patterns and Effects on Semen and Hormonal Parameters How to Stop TRT Safely

Embarking on the path of Testosterone Replacement Therapy (TRT) often evokes a blend of enthusiasm and concern among men. The allure of renewed vigor, heightened sexual desire, and robust muscle growth is enticing. However, there are a lot of less well-known aspects that your healthcare provider might not immediately disclose. For instance, were you aware that TRT could affect your fertility or exacerbate your sleep apnea? While TRT heralds a new dawn for many, it doesn’t offer a universal remedy. In light of this, we have meticulously curated a comprehensive list of 18 pivotal aspects that might elude your doctor's attention but are indispensable for you to grasp. Venture further to unearth the profundities of TRT. Low Blood Levels of Testosterone and Associated Risks: < 450 ng/dl (15.3 nmol/l) - Risk of metabolic syndrome Reference: Dhindsa, S., Miller, M. G., McWhirter, C. L., Mager, D. E., Ghanim, H., Chaudhuri, A., & Dandona, P. (2010). Testosterone concentrations in diabetic and nondiabetic obese men. Diabetes Care, 33(6), 1186-1192. PubMed < 400 ng/dl (15.3 nmol/l) - Venous leakage (internal penile damage) risk Reference: Yassin, A. A., & Saad, F. (2017). Testosterone Deficiency and Testosterone Treatment in Older Men. Gerontology, 63(2), 144–156. PubMed < 350 ng/dl (11.9 nmol/l) – All-cause death risk and anemia risk Reference: Khaw, K. T., Dowsett, M., Folkerd, E., Bingham, S., Wareham, N., Luben, R., ... & Day, N. (2007). Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men. Circulation, 116(23), 2694-2701. PubMed < 300 ng/dL (10.2 nmol/L) - Lowered libido, weight gain & Diabetes risk increased Reference: Traish, A. M., Saad, F., & Guay, A. (2009). The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction Journal of Andrology, 30(1), 10-22. PubMed < 300 ng/dL (10.2 nmol/L): Quartile risk of fractures (osteoporosis), memory-related issues and depression risk increases Reference: Orwoll, E., Lambert, L. C., Marshall, L. M., Phipps, K., Blank, J., Barrett-Connor, E.,... & Cummings, S. (2006). Testosterone and estradiol are common among older men. The Journal of Clinical Endocrinology & Metabolism, 91(4), 1336-1344. PubMed < 250 ng/dl (8.5 nmol/l): Arterial plaque (arteriosclerosis) & sleep quality affected Reference: Vlachopoulos, C., Ioakeimidis, N., Miner, M., & Aggelis, A. (2014). Testosterone deficiency: a determinant of aortic stiffness in men Atherosclerosis, 233(1), 278-283. PubMed < 235 ng/dl (8.0 nmol/l) hardening of arteries (dialysis patients) Reference: Carrero, J. J., Qureshi, A. R., Parini, P., Arver, S., Lindholm, B., Bárány, P., ... & Stenvinkel, P. (2009). Low serum testosterone increases mortality risk among male dialysis patients. Journal of the American Society of Nephrology, 20(3), 613-620. PubMed < 200 ng/dl (6.8 nmol/l) morning erections decrease Reference: O'Connor, D. B., Lee, D. M., Corona, G., Forti, G., Tajar, A., O'Neill, T. W., ... & EMAS Study Group. (2011). The relationships between sex hormones and sexual function in middle-aged and older European men. The Journal of Clinical Endocrinology & Metabolism, 96(10), E1577-E1587. PubMed < 150 ng/dl (5.1 nmol/l) - Increased inflammation (TNF-alpha) Reference: Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004). The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. The Journal of Clinical Endocrinology & Metabolism, 89(7), 3313-3318. PubMed The Unspoken Implications of TRT Your doctor might overlook mentioning certain ramifications when you commence Testosterone Replacement Therapy (TRT): Fertility and TRT Sperm Count Drop: TRT lowers the levels of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), two hormones that help make sperm. If preserving fertility is a priority, discuss with your healthcare provider incorporating Clomiphene or hCG into your TRT regimen. Hematological Effects Blood Viscosity Increase: TRT can escalate your blood's hematocrit level, thereby increasing its viscosity. Although some practitioners may advise halting TRT, this side effect can be managed adeptly through blood donations or therapeutic phlebotomy. Beware; frequent blood donations might deplete iron levels and induce fatigue. Impact on Natural Testosterone Production Suppression of Endogenous Testosterone: TRT suppresses your body’s natural testosterone synthesis, which may rebound anywhere between a few weeks and six months post-cessation. The Multifaceted Benefits and Varied Efficacy of TRT Muscle Mass, Fat Reduction, and Sexual Health Sex Drive and Physique Enhancement: TRT predominantly augments libido, muscle mass, and fat metabolism in men. However, its effectiveness varies, and meticulous dosage and frequency adjustments along with side effect management are imperative. It’s not a panacea. Administration Techniques Methods of Injection: Contrary to what most people think, testosterone can be injected superficially (IM) or deeply (subcutaneously) into the muscle using a 1/2-inch, 27-29-gauge insulin syringe. Topical Testosterone Efficacy of Gels and Creams: Testosterone gels and creams are efficacious but often under-dosed by physicians. More concentrated compounded products or dosage adjustments based on blood levels can rectify this. Dosage Frequency Optimized Injection Schedules: Shifting from biweekly 200mg injections to weekly 100mg or twice-weekly 50mg dosages can often yield better results. Addressing Concerns and Optimizing TRT Outcomes Sleep Apnea and TRT Sleep Apnea Dynamics: TRT could exacerbate central sleep apnea but might alleviate obstructive sleep apnea over time as weight loss occurs. Erectile Function Erectile Function and Libido: TRT enhances erectile function and libido in a majority of men. Some may benefit from adjunctive low-dose daily Cialis, which also harbors cardiovascular advantages. Self-Monitoring and Telemedicine Monitoring Blood Tests: Companies like DiscountedLabs.com enable self-monitoring of blood tests without a doctor visit. Moreover, telemedicine facilitates access to testosterone doctors nationwide, albeit mostly without insurance coverage. Debunking Misconceptions and Enhancing TRT Knowledge Prostate Health and Cardiovascular Effects Prostate Cancer and Heart Attacks: Contemporary evidence refutes the notion that TRT triggers prostate cancer or heart attacks, though vigilant monitoring is crucial for optimal cardiovascular outcomes. Community Support and Knowledge Sharing Leveraging Online Communities: Engage with seasoned TRT users on platforms like the ExcelMale forum or Testosterone Replacement Discussion Facebook group to broaden your understanding. Comprehensive Testing Holistic Blood Analysis: Ensure your doctor conducts a thorough blood analysis encompassing total and free testosterone, DHT, thyroid function, and prolactin (especially for those with extremely low T levels) to rule out pituitary adenomas. Insurance, Professional Expertise, and Addressing Common Hurdles Insurance and TRT Insurance Coverage: Insurance coverage for TRT products is often restrictive, but utilizing a compounding pharmacy can be a viable alternative. Expertise in TRT Management Urologists Leading the Charge: The burgeoning expertise of urologists in TRT management is notable, with extensive TRT-centric discussions now a staple at urology conferences. Identifying and Addressing Co-morbidities Co-morbid Conditions: Men with co-existing health issues may encounter challenges in reaping TRT benefits, warranting a thorough cardiovascular assessment for those experiencing water retention and hypertension. Estradiol Management Misconceptions About Estradiol: People often get the wrong idea about this hormone, which plays a big part in libido, bone health, and brain function, because it is not given enough attention when it comes to management. Emerging evidence suggests aromatase inhibition might be unnecessary in TRT management. Armed with this extensive knowledge, you’re now better positioned to make informed decisions on your TRT journey. Remember, individualized consultation with healthcare professionals is indispensable for optimizing your TRT experience.    

Table of Contents Background: Known roles of vitamin D in the body and why we need it Can supplementing vitamin D levels raise your testosterone levels? Vitamin D Study Results T synthesis in human primary testicular cell cultures Discussion of These Results How does it happen? References: Testosterone is the male hormone responsible for making us “feel like men, think like men, and look like men.” So in our never ending pursuit to raise our natural testosterone levels, we often look for positive correlations. You may have asked yourself these common questions: “If I up my intake of this nutrient, will my testosterone levels go up?” “If I take this supplement, will I have higher testosterone levels? This article aims to elucidate the relationship between vitamin D supplementation and whether or not a higher level of vitamin D can raise your testosterone levels. Background: Known roles of vitamin D in the body and why we need it First we need to understand what vitamin D really does in the body and why it is important. Vitamin D refers to a group of fat-soluble molecules responsible for increasing intestinal absorption of calcium, magnesium, phosphate, and zinc and multiple other biological effects. It has been known to help regulate blood pressure and to benefit cardiovascular health. It aids in maintaining homeostasis (balance) in the body and overall muscle and bone health[1]. It has also been proven to regulate cell growth and decrease the risk ofcancer in the prostate, breasts, colon, and lungs. Although most Vitamin D is synthesized in the skin through UVB ray absorption from the sun, there are some foods that have naturally high levels of vitamin D, including fatty fish such as salmon, milk, and orange juice. However, most people do not get enough sun or consume Vitamin D-enriched foods to reach optimum blood levels of this important vitamin. For most, supplementation is the only way to maintain healthy Vitamin D blood levels. Now, how does vitamin D relate to testosterone? Let’s find out. Can supplementing vitamin D levels raise your testosterone levels? A study concluded that lower serum vitamin D3 levels are associated with lower testosterone levels. [2] There has also been speculation that adequate vitamin D levels can actually raise testosterone levels. Is there any basis behind this speculation and if so, what is the mechanism? In 2014 the Journal of Clinical Endocrinology and Metabolism published a groundbreaking paper, written by D. Hofer, J. Münzker, et al, on the subject titled “Testicular synthesis and Vitamin D Action”. For the first time, human (vs animal) adult primary testicular cells were isolated, treated with 1,25(OH)2D3 (vitamin D3), and their gene expression levels were profiled by microarray analysis. They were able to determine that there was a SIGNIFICANT INCREASE IN SERUM TESTOSTERONE LEVELS WHEN PRIMARY TESTICULAR CELLS WERE TREATED WITH VITAMIN D3 VS CONTROL GROUP. [3] Vitamin D Study Results The authors wanted to measure overall testosterone production when various variables were changed. Keep in mind, 1,25(OH)2D3, is Vitamin D3, the biologically active form of Vitamin D. T synthesis in human primary testicular cell cultures First, let’s look at graph A. It demonstrates a significant increase in T production after exclusive addition of 100 nM 1,25(OH)2D3 (Vitamin D3) (P < .001) compared with control cells treated with vehicle (ethanol) (Figure 3A). Next, let’s look at graph B. Addition of 5 IU/L LH, 100 ng/mL IGF-I together with 100 nM 1,25(OH)2D3 significantly increased T levels (P < .05) (Figure 3B), compared with treatment with LH or LH and IGF-I only. Results are represented as means ± SD. *, P < .05; ***, P < .001. NC, control (vehicle). Discussion of These Results The study researchers saw a SIGNIFICANT INCREASE IN TESTOSTERONE LEVELS WHEN PRIMARY TESTICULAR CELLS ARE TREATED WITH VITAMIN D3. Keep in mind though, the level of vitamin D used by our authors would be well above any normal physiological level found in any person. According to The Merck Manual of Diagnosis and Therapy 2013, most reliable reference ranges for vitamin D3 put normal serum blood levels somewhere between 25–65 pg/mL. Our authors used 100ng/ml of vitamin D3 to treat these cells, which is somewhere between 300-1200 times a healthy reference range.[4] If our serum concentration of D3 were to ever get that high, our serum calcium levels would skyrocket and our internal organs would begin to calcify.[4] Organ failure would ensue and ultimately we would die. SO, although we can conclusively say that yes, higher vitamin D3 levels can raise testosterone levels, you will never see a 50% increase in your testosterone level as seen in this study by supplementing vitamin D3 [3,4]. How does it happen? In a nutshell, the authors were able to analyze which and how many proteins were being produced by the genes in these testicular cells. So, how do these proteins relate to testosterone production? Let’s take a look at our famous “Steroid Tree”   This tree outlines steroidogenesis, the process our body (mainly in our sex organs) undergoes to produce our sex steroids/hormones. All steroid hormones including testosterone originate from cholesterol, as seen at the bottom of the tree. In the KEY to Steroid Enzymes box, we see the necessary enzymes that are required to move about the tree, located between each structure. These ENZYMES are some of the PROTEINS that the GENES in our testicular cells are producing. The authors of thispaper measured GENE EXPRESSION, or the level at which the genes in the testicular DNA produced these enzymes/proteins. All in all, they chose 63 different genes to analyze. Of those 63, 6 displayed promising results. Results:   Do you notice anything about these genes and the enzymes they produce? Four of them match with the “KEY to Steroid Enzymes” box in our “Steroid Tree” diagram. Below: Stated first is the gene name, second is the enzyme the gene produces, and the third is the corresponding number of that enzyme on our steroid tree. · CYP11A1: Cholesterol side-chain cleavage enzyme: 1 · HSD3B2: 3β-hydroxysteroid dehydrogenase II : 3 · SRD5A1: 5α-reductase: 5 · CYP19A1: Aromatase: A 1 is essential to our primary step of converting cholesterol to pregnenolone 3 is absolutely essential in getting to testosterone. In conclusion, theauthors proposed that vitamin D3 increases testosterone levels by increasing the number of enzymes available to (eventually) convert cholesterol to testosterone. This is how vitamin D3 raises testosterone! Of Note: It is interesting to note that Aromatase activity was also increased significantly. Aromatase is the enzyme responsible for converting testosterone into estradiol. It has been shown that low levels of vitamin D are associated with low levels of estradiol in men. [5] 5a-Reductase production was also increased. 5a-reductase is the enzyme responsible for converting testosterone to DHT. Both estradiol and DHT can have minor deleterious effects to male health if present in high concentrations in the blood. Thiswill be discussed in future articles. References: 1. L.A. Schaap, S.M.F. Pluijm, J.H. Smit, N.M. van Schoor, M. Visser, L.J.G. Gooren, et al. “The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women.” Clin. Endocrinol. (Oxf.), 63 (August (2)) (2005), pp. 152-160 2. R. Rafiq. N.M. van Schoor, E. Sohl, M.C. Zillikens, M.M. Oosterwerff. Associations of vitamin D status and vitamin D-related polymorphisms with sex hormones in older men. The Journal of Steroid Biochemistry and Molecular Biology. Volume 164, November 2016, Pages 11-17 3. D. Hofer, J. Münzker, V. Schwetz, M. Ulbing, K. Hutz, Ph. Stiegler, R. Zigeuner, T. R. Pieber, H. Müller, B. Obermayer-Pietsch. Testicular Synthesis and Vitamin D Action. J Clin Endocrinol Metab (2014) 99 (10): 3766-3773. 4. Ziegler R (February 2001). "Hypercalcemic crisis". J. Am. Soc. Nephrol. 12 Suppl 17: S3–9. 5. Di Zhaoa Pamela Ouyangb, Ian H. de Boerc, Pamela L. Lutseyd, “Serum vitamin D and sex hormones levels in men and women: The Multi-Ethnic Study of Atherosclerosis (MESA)” Maturitas. Volume 96, February 2017, Pages 95–102