Lipoprotein a Test
Lipoprotein (a) has been called a powerful predictor of premature atherosclerotic vascular disease. As an independent risk factor for premature coronary artery disease, excess Lp(a) concentrations are associated with an increased risk of cardiac death in patients with acute coronary syndromes and with restenosis after angioplasty (PTCA) and coronary bypass procedures. In general, concentrations greater than or equal to 75 nmol/L of Lp(a) in serum are associated with a two- to sixfold increase in risk, depending on the presence of other risk factors.
Lipoprotein a Test
Lipoprotein (a) has been called a powerful predictor of premature atherosclerotic vascular disease. Extra Lp(a) levels are linked to a higher risk of cardiac death in people with acute coronary syndromes and who have restenosis after angioplasty (PTCA) and coronary bypass procedures. This is because they are an independent risk factor for early coronary artery disease. In general, concentrations greater than or equal to 75 nmol/L of Lp(a) in serum are associated with a two- to sixfold increase in risk, depending on the presence of other risk factors. High Lp(a) can also lead to narrowing of the aortic valve, called aortic stenosis, because of its role in inflammation. Chronic inflammation leads to calcium build up on the valve, causing stiffness. This can result in reduced blood flow if the valve is unable to open completely. In some cases, people with aortic stenosis need surgery or a procedure to replace the aortic valve.
Lipoprotein(a) has been called a powerful predictor of premature atherosclerotic vascular disease and cardiovascular disease risk. As an independent risk factor for premature coronary artery disease, excess Lp(a) concentrations are associated with an increased risk of cardiac death in patients with acute coronary syndromes and restenosis after angioplasty (PTCA) coronary bypass procedures. In general, concentrations greater than or equal to 75 nmol/L of Lp(a) in serum are associated with a two- to sixfold increase in cardiovascular disease risk, depending on other risk factors.
The lipoprotein a test is an independent risk factor for coronary artery disease and cerebral infarction (in white populations) equal to high LDL cholesterol. Serum concentrations are genetically determined. Fifteen percent to 20% of the white population have Lp(a) levels ≥75 nmol/L and are presumed to be at risk. Race-dependent differences in Lp(a) concentrations are known. The significance of high Lp(a) in nonwhite populations must be evaluated with caution. The Lp(a) levels in different ethnic populations can vary widely. Africans, or people of African descent, generally have Lp(a) levels higher than Caucasians and Asians, while Native Americans generally have levels lower than Caucasians. This variability of Lp(a) levels by ethnic population requires careful interpretation of results based on a knowledge of the patient and other cardiac risk factors that may be present.
A blood test called the Lipoprotein(a) [Lp(a)] test is used to determine the levels of Lipoprotein(a) [Lp(a)], a kind of lipoprotein that shares structural similarities with LDL (low-density lipoprotein), or "bad" cholesterol. Increased Lp(a) levels are considered a risk factor for cardiovascular disease because they can aid in forming arterial plaque, which can lead to the development of various serious medical conditions, such as atherosclerosis or "hardening of the arteries."
Lipoprotein a: What it is, its normal range, and what to do if it's high
Lipoprotein(a), or Lp(a), is a type of lipoprotein that is found in the bloodstream. Lp(a) is made up of a protein called apolipoprotein(a) . Lp(a) is similar to LDL (low-density lipoprotein) in terms of its structure and function, but it has an additional protein called apolipoprotein(a) attached to it . Lp(a) is thought to be a marker of cardiovascular disease and may contribute to the development of atherosclerosis .
Normal range of lipoprotein a test
There is no established "normal range" for Lp(a) levels, as they can vary widely between individuals . However, in general, Lp(a) levels above 30 mg/dL (milligrams per deciliter) are considered high .
Risk | nmol/L
- Optimal | <75
- Moderate | 75-125
- High | >125
What to do if lipoprotein a test result is high
If a person has high Lp(a) levels, there are several steps they can take to help manage their risk of cardiovascular disease. The following strategies may be recommended by a healthcare provider [4, 5]:
- Lifestyle changes: Maintaining a healthy diet and regular exercise can help improve cholesterol levels and reduce the risk of heart disease. Quitting smoking and limiting alcohol intake can also be beneficial.
- Medications: Certain medications, such as niacin, fibrates, and statins, can help lower Lp(a) levels in some people. However, the effectiveness of these drugs may vary depending on the individual.
- Regular check-ups: Regular monitoring of Lp(a) levels and overall cardiovascular health is important for people with high Lp(a) levels. This may involve regular blood tests, as well as assessments of blood pressure, cholesterol levels, and other risk factors for heart disease.
- Other interventions: In some cases, more aggressive interventions may be necessary to manage high Lp(a) levels. For example, a healthcare provider may recommend apheresis, a procedure that removes Lp(a) from the blood .
In summary, Lp(a) is a type of lipoprotein that may contribute to the development of cardiovascular disease. While there is no established "normal range" for Lp(a) levels, levels above 30 mg/dL are generally considered high risk. People with high Lp(a) levels may benefit from lifestyle changes, medications, regular check-ups, and other interventions to manage their high risk. If you have concerns about your Lp(a) levels or overall cardiovascular health, talk to your healthcare provider to discuss the best strategies for managing your high risk.
The following are some lipoprotein a test related frequently asked questions:
What is the Lipoprotein a level normal range?
A: Lp(a) levels that are considered elevated are those that are greater than 30 mg/dL in the normal range. Some professionals define high readings as those more than 10 mg/dL.
What do elevated Lp(a) levels mean?
A: Heart attack, stroke, and peripheral artery disease are all related with an elevated risk of cardiovascular disease in people with high levels of Lp(a) (over 30 mg/dL).
What do low lipoprotein a test results levels suggest?
A: A lower risk of cardiovascular disease is linked to low levels of Lp(a) (below 10 mg/dL).
What are the danger signs of elevated Lp(a) levels?
A: Family history of cardiovascular disease, advanced age, high LDL cholesterol levels, and a history of smoking are risk factors for high Lp(a) levels.
How can I reduce the amounts of Lp(a) in my body?
A: By changing your lifestyle to include regular exercise, a good diet, giving up smoking, and stress management, you can lower your Lp(a) levels. Medications like statins, for example, may also aid in lowering Lp(a) levels.
How exactly is the Lp(a) test run?
A blood sample is drawn for the Lp(a) test, which is subsequently sent to a lab for evaluation.
An Lp(a) test should be read in conjunction with other lipid panel tests, other clinical information, and laboratory data because it is not a diagnostic tool on its own. Additionally, it's crucial to speak with a medical professional to go through the findings and any possible health consequences.
FASTING IS REQUIRED
 Medical News Today. (2022). Lipoprotein(a): What it is, test results, and what they mean. https://www.medicalnewstoday.com/articles/lipoprotein-a-what-it-is-test-results-and-what-they-mean
 Cleveland Clinic. (2022). Lipoprotein. https://my.clevelandclinic.org/health/articles/23229-lipoprotein
 WebMD. (2022). What is the lipoprotein test? https://www.webmd.com/heart-disease/what-is-lipoprotein-test
 MedlinePlus. (2022). Lipoprotein(a) blood test. https://medlineplus.gov/lab-tests/lipoprotein-a-blood-test/
 Centers for Disease Control and Prevention. (2022). Lipoprotein(a) fact sheet. https://www.cdc.gov/genomics/disease/lipoprotein_a.htm
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