Protein, Gloublin and Albumin - The major proteins seen in the serum are albumin and globulin-the latter being primarily alpha 1 and alpha 2 globulin, beta globulin and gamma globulin. Albumin accounts for more than 50% of the total serum proteins. The albumin to globulin (A/G) ratio has been used as an index of disease state, however, it is not a specific marker for disease because it does not indicate which specific proteins are altered. The normal A/G ratio is 0.8-2.0. The A/G ratio can be decreased in response to a low albumin or to elevated globulins. Total globulins may be increased in some chronic inflammatory diseases (TB, syphilis) multiple myeloma, collagen disease, and rheumatoid arthritis.  Decreased levels are seen in hepatic dysfunction, renal disease and various neoplasms.

This panel includes: Testosterone, Total, LC/MS and Free (Equilibrium Dialysis), and 17-OH-progesterone, a metabolite that has been correlated with sperm production.

Testosterone Replacement Therapy (TRT) shuts down upstream hormones like LH and FSH required for sperm production, so men on TRT generally have a difficult time fathering a child. Some studies show that adding hCG to a TRT protocol may improve sperm production since hCG is an analog of LH that could stimulate sperm production. But optimizing hCG dose and frequency based on sperm count can be a time consuming process since it takes at least 8 weeks to see changes in sperm tests. Fortunately, there is an easier way by measuring 17-OH-progesterone to predict the efficacy of the hCG+TRT protocol without having to wait for 8 weeks between hCG dose/frequency changes.