Thyroxine-binding globulin (TBG) is a globulin that binds thyroid hormones in circulation. It is one of three transport proteins (along with transthyretin and serum albumin) responsible for carrying the thyroid hormones thyroxine (T4) and triiodothyronine (T3) in the bloodstream. Of these three proteins, TBG has the highest affinity for T4 and T3 but is present in the lowest concentration. Despite its low concentration, TBG carries the majority of T4 in the blood plasma.

Protein, Gloublin and Albumin - The major proteins seen in the serum are albumin and globulin-the latter being primarily alpha 1 and alpha 2 globulin, beta globulin and gamma globulin. Albumin accounts for more than 50% of the total serum proteins. The albumin to globulin (A/G) ratio has been used as an index of disease state, however, it is not a specific marker for disease because it does not indicate which specific proteins are altered. The normal A/G ratio is 0.8-2.0. The A/G ratio can be decreased in response to a low albumin or to elevated globulins. Total globulins may be increased in some chronic inflammatory diseases (TB, syphilis) multiple myeloma, collagen disease, and rheumatoid arthritis.  Decreased levels are seen in hepatic dysfunction, renal disease and various neoplasms.

These two tests measure antithyroglobulin antibodies and Anti-TPO antibodies that are commonly present in patients with Hashimoto's thyroiditis, Graves disease and other thyroid-related conditions. Antibodies against the protein thyroglobulin can result in the destruction of thyroid cells. TPO antibodies are created when the immune system of a person targets by pure error elements of the thyroid gland or protein, leading to chronic thyroid inflammation, tissue damage, and damage to the thyroid function. Leaving this untreated may cause severe health issues. 

This test measures thyroglobulin antibodies commonly present in patients with Hashimoto's thyroiditis. Antibodies against the protein thyroglobulin can result in the destruction of thyroid cells. This destruction can lead to hypothyroidism. NOTE: Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

Comprehensive and All-Inclusive Lab Test Panel for clients of The Wellness By Design Project.  The panel includes:  Testosterone Free with Total, Estrogens Total, Estrone, Estradiol, DHEA-S, Progesterone, Pregnenolone, Dihydrotestosterone (DHT), FSH/LH, Cortisol, Prolactin, TSH, Free T3, Free T4, Reverse T3, Anti TPO, AntiTG, C-reactive protein (high sensitivity), Homocysteine, Apolipoprotein B, Insulin-like Growth Factor 1 (IGF-1), Insulin, Sex Hormone Binding Globulin (SHBG), Vitamin D 25-hydroxy, Complete Metabolic Panel, Gamma Glutamyl Transferase (GGT), Lipid Profile, Complete Blood Count (CBC), Hemoglobin A1C (HbA1C), Magnesium (serum), Phosphorus (serum), LDH, Uric Acid, Iron Serum, Total Iron Binding Capacity (TIBC), Iron Saturation, Ferritin, and Fibrinogen activity.

Tests included are:

Complete Blood Count with Differential (CBC)
Comprehensive Metabolic Panel (CMP)
Hemoglobin A1c
Cardio IQ Advanced Lipid Panel
Urinalysis, Complete
TSH
Thyroid Free T3
Thyroid Free T4
Reverse T3
TPO Antibodies
Thyroglobulin Antibodies
Homocysteine
Cardio C-Reactive Protein
CPK
Estradiol, Ultra Sensitive
Testosterone Total & Free (LC/MS- No upper limit)
DHEA – S
Prolactin
DHT
IGF-1
Progesterone
Estrone
Total Estrogens
LH + FSH
Anti-Müllerian Hormone (AMH)
Vitamin D (25OHD)
Vitamin B-12
Folate
Ferritin
Iron & TIBC (Total Iron Binding Capacity)

This Testosterone Panel Includes 5 Tests:

• Testosterone, Total, LC/MS (most accurate testosterone test for men with high testosterone and women, no upper or lower limit)
• Testosterone, Free. Free testosterone is best calculated based on the LC/MS-derived total testosterone and equilibrium dialysis-derived percent free levels. 
• Testosterone, Bioavailable. Bioavailable testosterone is calculated based on the LC/MS/MS-derived total testosterone,  free testosterone levels, albumin and SHBG.
• Sex Hormone Binding Globulin (SHBG)
• Albumin

Note: Despite SHBG not being listed on the lab requisition form under "Testosterone, Free, Bioavailable, and Total, Males (Adult)," rest assured the results include this critical component, as it's necessary for calculating bioavailable testosterone.

This is the most cost effective testosterone test panel that takes the least amount of time to perform and that includes 5 important tests: 1- Total testosterone, 2- Calculated free testosterone, 3- Bioavailable (unbound) testosterone, 4- Sex hormone binding globulin (SHBG), and albumin. Testosterone upper limit under 1,500 ng/dL (ECLIA, immunoassay). It is accurate for most men using or not using TRT . For men expecting very high testosterone blood levels over 1,500 ng/dL or low total T below 250 ng/dL, the LC/MS testosterone test is more appropriate, but it takes a few more days to perform. NOTE: Despite SHBG not being listed on the lab requisition form under "Testosterone, Free, Bioavailable, and Total, Males (Adult)," rest assured the results include this critical component, as it's necessary for calculating bioavailable testosterone.

Includes liver and kidney function, glucose and electrolytes

This test measures the free (unbound to SHBG or albumin) estradiol and total sensitive estradiol in blood. The test is performed using liquid chromatography/mass spectrometry (LC/MS). NOTE: This test is a send out test to Quest's Nichols Institute San Juan Capistrano.  Testing schedule is Mon and Wed.  Reports are available within 4-14 days from the time the specimen is received at the send out testing lab. Test results may take up to 16 business days.

Cortisol (hydrocortisone) is the most prominent glucocorticosteroid, and it is essential for the maintenance of several body functions. The most important physiological effects of cortisol are that it raises blood sugar levels (enhances gluconeogenesis, or breaks down glucose) and lowers inflammation and the immune system.

This diabetes panel includes important tests usually prescribed for anyone living with Type 1 or Type 2 diabetes. It includes A1c, CMP, Urinialysis, Insulin, and Glucose Tolerance Test (GTT).

The Rheumatoid Arthritis Factor is often evaluated in patients suspected of having any form of arthritis or destructive articular disease even though positive results can be due to other causes, and negative results do not rule out disease. But, in combination with signs and symptoms, it can play a role in both diagnosis and disease prognosis. It is part of the usual disease criteria of rheumatoid arthritis.

THIS IS THE MOST AFFORDABLE TESTOSTERONE TEST IN THE U.S. The most accurate way to measure total testosterone is with liquid chromatography/mass spectrometry. This panel also shows free testosterone percent by equilibrium dialysis and free testosterone calculated from percent free T. This test is more accurate for low and high testosterone blood levels (for men who expect high testosterone blood levels over 1,500 ng/dL, women, and children who usually have low T levels). It has no interferences with supplements or anabolics. Note: Results may take 5-7 business days. For a faster turnaround, choose this test instead: Testosterone, Free, Bioavailable and Total (With Lower & Upper Limit) plus SHBG

This panel includes comprehensive testing of the thyroid stimulating hormone (TSH) in addition to free thyroxine (T4) and free triiodothyronine (T3).

Blood typing is used to determine an individual's blood group, to establish whether a person is blood group A, B, AB, or O and whether he or she is Rh positive or Rh negative.

The thyroid gland produces and secretes T4, otherwise known as thyroxine. Proteins bind to T4 and carry it throughout the bloodstream. Once in the tissues, T4 is released from the proteins and is now free to convert into the more active form called T3. For this reason, many doctors believe that measuring free T4 is a more sensitive test for thyroid hormone production.