Women and men living with fibromyalgia do not have characteristic or consistent abnormalities on laboratory testing. However, routine laboratory and imaging studies are important to help rule out diseases with similar manifestations and to assist in diagnosis of certain inflammatory diseases that frequently coexist with fibromyalgia. These are the lab tests commonly checked by physicians treating fibromyalgia patients: CMP, CBC, Urinalysis, TSH, Vitamin D & B-12, Iron/TIBC, Magnesium in RBC, ESR, CPK and Ferritin.

Protein, Gloublin and Albumin - The major proteins seen in the serum are albumin and globulin-the latter being primarily alpha 1 and alpha 2 globulin, beta globulin and gamma globulin. Albumin accounts for more than 50% of the total serum proteins. The albumin to globulin (A/G) ratio has been used as an index of disease state, however, it is not a specific marker for disease because it does not indicate which specific proteins are altered. The normal A/G ratio is 0.8-2.0. The A/G ratio can be decreased in response to a low albumin or to elevated globulins. Total globulins may be increased in some chronic inflammatory diseases (TB, syphilis) multiple myeloma, collagen disease, and rheumatoid arthritis.  Decreased levels are seen in hepatic dysfunction, renal disease and various neoplasms.