Page 3 - TRT Testing

The prostate gland plays a pivotal role in men’s health, and its well-being is often a topic of great concern, especially when it comes to prostate cancer, a leading cause of death among men in the United States. This article delves into the intricacies of prostate health, detection methods for prostate cancer, and the debated connection between testosterone replacement therapy (TRT) and prostate cancer. Prostate Cancer Prevalence and Detection As men age, the occurrence of small, hidden prostatic lesions increases, which could potentially turn cancerous over time. The prevalence of these lesions is around 30% in American men aged over 45, and this figure soars to over 80% for those above 80 years of age. The transformation of these lesions into cancerous cells is often linked to genetic factors and lifestyle conditions, including diet. To detect prostate cancer, healthcare providers employ a variety of methods: Prostate-Specific Antigen (PSA) assays Digital Rectal Examination (DRE) Transrectal Ultrasound It's advisable for men, especially those above 40 or with a family history of prostate cancer, to undergo a DRE before commencing testosterone replacement therapy and every six months thereafter. While DRE may be uncomfortable, it's a small price to pay for ensuring good health. Any abnormal rectal exam findings, a PSA increase of more than 2 ng/mL, or a PSA level over 4 ng/mL usually necessitate further evaluation by a urologist, often involving an ultrasound and prostate biopsies. However, the PSA and DRE methods lack sensitivity and specificity. In some instances, benign prostatic hyperplasia (BPH), a non-cancerous inflammation, may falsely elevate PSA levels, while 25% of prostate cancer patients show normal PSA levels. As it turns out, needle biopsies can find hidden prostatic lesions in men whose PSA levels and ultrasound results are normal. Testosterone Replacement Therapy and Prostate Cancer: Unveiling the Connection The role of Testosterone Replacement Therapy (TRT) in PSA elevation or prostate cancer development has been a topic of considerable debate. Prostate cancer is initially androgen-dependent; thus, TRT is discouraged for men diagnosed with prostate cancer. However, a comprehensive analysis encompassing data from 18 studies revealed no significant link between blood levels of androgens and an increased risk for prostate cancer (Journal of the National Cancer Institute, 2008). Intriguingly, some emerging data suggest that high doses of testosterone may be beneficial in treating certain types of prostate cancer. A different study that looked at 149,354 men who were diagnosed with prostate cancer between 1991 and 2007 found that those who were treated with TRT did not have higher rates of death or use of Androgen Deprivation Therapy (ADT). The study, published in the Journal of Sexual Medicine (2014), concluded that TRT, post-prostate cancer diagnosis and treatment, doesn't exacerbate mortality rates or the necessity for ADT, even with prolonged TRT duration. Conclusion The dialogue surrounding prostate cancer, its detection, and the implicated role of TRT is complex. While the journey towards unambiguous understanding continues, regular screenings and open discussions with healthcare providers remain crucial for maintaining prostate health and making informed treatment decisions.   Reference: Kaplan, A. L., Lenis, A. T., Shah, A., Rajfer, J., & Hu, J. C. (2014). Testosterone Replacement Therapy in Men with Prostate Cancer: A Time-Varying Analysis. Journal of Sexual Medicine. For more insights on this topic, refer to: Does Testosterone Cause Prostate Cancer? Can Men Treated for Prostate Cancer Use TRT?

Starting Testosterone Replacement Therapy (TRT) is a significant decision that can have a profound impact on your health and well-being. While it offers numerous benefits, like enhanced mood, improved sexual performance, and increased muscle mass, there are also potential side effects and nuances that your healthcare provider might not fully explain. Below, we delve into critical aspects of TRT that every man should be aware of. But first, did you know that you can easily and affordably monitor your testosterone levels through DiscountedLabs.com? It's an excellent way to keep track of your health without the hassle of a doctor's visit. Table of Contents Impact on Sperm Count How TRT Affects Your Fertility Blood Viscosity and Hematocrit Managing Increased Red Blood Cells Shutdown of Natural Testosterone Production Recovery Post TRT Dose and Effectiveness TRT is Not a Magic Bullet Different Injection Methods Subcutaneous vs. Intramuscular Testosterone Gels and Creams Topical TRT: Right Dose, Right Results Optimal Injection Frequency The Shift Towards Frequent Dosing Sleep Apnea TRT and Sleep Quality Erectile Function and Libido The Added Benefits and Limitations Monitoring Your Blood Tests Taking Charge of Your Health Telemedicine for TRT Access to Expertise Prostate Cancer and Heart Attacks Debunking the Myths Community Support You're Not Alone Important Blood Tests Beyond Total Testosterone Insurance Limitations Navigating the System Consult a Urologist The Go-To Experts on TRT Comorbidities Risks and Workarounds The Estradiol Obsession Re-Thinking Estradiol Management Impact on Sperm Count How TRT Affects Your Fertility One aspect of TRT that is often overlooked is its effect on fertility. TRT reduces levels of LH (Luteinizing Hormone) and FSH (Follicle Stimulating Hormone), which are crucial for sperm production. If you plan on having children, it's essential to discuss fertility preservation options with your healthcare provider. Treatments like clomiphene or the addition of hCG can be useful. Blood Viscosity and Hematocrit Managing Increased Red Blood Cells TRT may lead to an increase in hematocrit, or the amount of red blood cells in your blood, thereby making it thicker. While some doctors may suggest pausing TRT, this condition can be managed through blood donations or therapeutic phlebotomy. However, frequent blood donations can lead to iron depletion and fatigue. Learn more about managing high hematocrit here. Shutdown of Natural Testosterone Production Recovery Post TRT Once you're on TRT, your natural testosterone production will decline. Usually, your body can recover its testosterone levels within a few weeks to six months after stopping TRT, but it's essential to know that this therapy isn't a temporary commitment. Dose and Effectiveness TRT is Not a Magic Bullet Though TRT can dramatically improve quality of life by enhancing sex drive, muscle mass, and fat loss, the effectiveness varies from person to person. Factors like dose, frequency, and side effect management play a crucial role. Learn about the average time to see benefits. Different Injection Methods Subcutaneous vs. Intramuscular There's a common misconception that testosterone must be injected deep into the muscle. However, you can also use a 1/2 inch 27-29 gauge insulin syringe for subcutaneous injections. Read more about injection methods here. Testosterone Gels and Creams Topical TRT: Right Dose, Right Results Gels and creams offer a less invasive way to administer testosterone, but the effectiveness depends on the right dose and concentration. Doctors often miss this, so make sure you monitor your levels closely. Optimal Injection Frequency The Shift Towards Frequent Dosing Traditionally, doctors prescribed testosterone injections at 200 mg every two weeks. However, many are moving towards more frequent dosing schedules, like 100 mg per week or even 50 mg twice per week, using insulin syringes. Sleep Apnea TRT and Sleep Quality Be cautious if you have central sleep apnea, as TRT can worsen this condition. However, weight loss achieved through TRT may improve obstructive sleep apnea over time. Erectile Function and Libido The Added Benefits and Limitations While TRT generally improves libido, the results regarding erectile function are mixed. Some men also use low-dose Cialis for additional cardiovascular benefits. Read more about the benefits of Cialis. Monitoring Your Blood Tests Taking Charge of Your Health One of the great advantages of modern technology is that you can monitor your own blood tests via DiscountedLabs.com, without needing a doctor's appointment. Telemedicine for TRT Access to Expertise For those living in areas without easy access to a TRT specialist, telemedicine is a viable option. Just note that most telemedicine doctors don't accept insurance. Prostate Cancer and Heart Attacks Debunking the Myths Contrary to common belief, TRT has not been proven to cause prostate cancer or heart attacks. Proper monitoring of hematocrit, HDL, and blood pressure is crucial, however. Community Support You're Not Alone Don't underestimate the value of community support. Platforms like Excel Male Forum offer a wealth of shared experiences and advice from men who have been on TRT for years. Important Blood Tests Beyond Total Testosterone Many doctors only measure total testosterone and often neglect other important markers like free testosterone, DHT, and thyroid function. Ensure these are part of your monitoring plan. Insurance Limitations Navigating the System Most insurance companies have limitations on which TRT products they cover. You can bypass insurance restrictions by going through a compounding pharmacy. Consult a Urologist The Go-To Experts on TRT Urologists are becoming increasingly knowledgeable about TRT, making them an excellent resource for anyone considering this treatment. Comorbidities Risks and Workarounds Some men might not see the benefits of TRT due to other health issues, such as metabolic disorders that can lead to water retention and high blood pressure. A full work-up with a cardiologist is advisable for these men. The Estradiol Obsession Re-Thinking Estradiol Management Many men obsess about their estradiol levels and are often prescribed high doses of aromatase inhibitors, which may not be necessary. Learn more about the role of estradiol in men here. In conclusion, TRT is a multifaceted treatment that requires proper understanding and management. Keep yourself informed and consider using DiscountedLabs.com for your testosterone level monitoring. Take control of your health today!

Testosterone, a vital hormone predominantly found in males, plays a crucial role in various physiological processes such as sexual development, muscle growth, bone density, and overall well-being. Recent studies have raised concerns about a decline in serum testosterone levels among adolescents and young adult men in the United States. This article aims to explore the potential causes, implications, and scientific evidence surrounding this phenomenon. Factors Contributing to Declining Testosterone Levels in Young Men Lifestyle Changes Sedentary behavior, unhealthy dietary patterns, and an increase in screen time have been linked to lower testosterone levels. Lack of physical activity and poor nutrition can lead to weight gain, which is associated with reduced testosterone production [1]. Endocrine Disruptors Exposure to endocrine-disrupting chemicals (EDCs) such as phthalates, bisphenol A (BPA), and pesticides has been suggested as a potential contributor to declining testosterone levels. These chemicals, commonly found in plastics, personal care products, and certain foods, can interfere with hormonal balance and disrupt testosterone synthesis [2]. Stress and Mental Health Chronic stress and mental health disorders, including depression and anxiety, may negatively impact testosterone production. Elevated cortisol levels, often associated with stress, can suppress testosterone synthesis [3]. Obesity and Insulin Resistance The rising prevalence of obesity and insulin resistance among adolescents and young adults has been linked to lower testosterone levels. Excess body fat can promote the conversion of testosterone into estrogen, leading to hormonal imbalances [4]. Implications of Declining Testosterone Levels Sexual and Reproductive Health Testosterone is essential for normal sexual function, including libido, erectile function, and sperm production. Declining testosterone levels may contribute to sexual dysfunction and reduced fertility in affected individuals. Physical Health Testosterone plays a crucial role in maintaining muscle mass, bone density, and overall physical well-being. Decreased testosterone levels may lead to decreased muscle strength, increased risk of osteoporosis, and compromised overall health. Psychological Well-being Testosterone influences mood, cognition, and overall psychological well-being. Low testosterone levels have been associated with symptoms such as fatigue, depression, irritability, and reduced quality of life. Scientific Evidence and Studies A study published in the Journal of Clinical Endocrinology & Metabolism in 2006 analyzed data from the National Health and Nutrition Examination Survey (NHANES) and found a significant decline in testosterone levels among men aged 20-74 years between 1988 and 2004 [5]. Another study published in JAMA Internal Medicine in 2020 examined testosterone levels in over 4,000 young men aged 15-39 years from 2009 to 2016. The findings indicated a substantial decline in testosterone levels during this period [6]. Research published in the journal Environmental International in 2020 explored the association between phthalate exposure and testosterone levels in young men. The study suggested that higher urinary phthalate metabolite concentrations were associated with lower testosterone levels [7]. Conclusion The decline in serum testosterone levels among adolescents and young adult men in the USA is a concerning trend with potential implications for sexual and reproductive health, physical well-being, and psychological functioning. Lifestyle factors, endocrine disruptors, stress, obesity, and insulin resistance are among the factors contributing to this decline. Further research is needed to understand the extent of the issue and develop strategies to address and mitigate the potential consequences. Buy the most affordable testosterone test in the country on DiscountedLabs.com References: Araujo AB, Dixon JM, Suarez EA, et al. Clinical review: Endogenous testosterone and mortality in men: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011;96(10):3007-3019. Haider A, Yassin A, Doros G, Saad F. Effects of long-term testosterone therapy on patients with "diabesity": results of observational studies of pooled analyses in obese hypogonadal men with type 2 diabetes. Int J Endocrinol. 2014;2014:683515. Morales A, Bebb RA, Manjoo P, et al. Diagnosis and management of testosterone deficiency syndrome in men: clinical practice guideline. CMAJ. 2015;187(18):1369-1377. Almeida OP, Hankey GJ, Yeap BB, et al. Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men. Arch Gen Psychiatry. 2008;65(3):283-289. Travison TG, Araujo AB, O'Donnell AB, et al. A population-level decline in serum testosterone levels in American men. J Clin Endocrinol Metab. 2007;92(1):196-202. O'Connor DB, Archer J, Wu FC. Effects of testosterone on mood, aggression, and sexual behavior in young men: a double-blind, placebo-controlled, cross-over study. J Clin Endocrinol Metab. 2004;89(6):2837-2845. Hammoud A, Gibson M, Peterson CM, et al. Impact of male obesity on infertility: a critical review of the current literature. Fertil Steril. 2008;90(4):897-904.

Table of Contents SHBG and the Free Testosterone Relationship What Causes High SHBG? Other factors that can contribute to high SHBG include:   Get Your Levels Checked: SHBG Test, Free & Total Testosterone Test How to Lower SHBG Levels: Very Low SHBG : Low SHBG has also been associated with: Is SHBG an Enemy of Hormone? - Emerging Studies References: Testosterone is the primary and dominant male hormone. It is responsible for numerous functions within the human body in men and women, and when levels are too low, it can lead to multiple health issues. Unfortunately, as many know, testosterone levels naturally decline as we age. Numerous external factors can contribute to lower levels of testosterone. In either case, age or external, symptoms occur, problems arise, and solutions are needed to stop the decline. For many men, testosterone replacement therapy (TRT) is the answer to this problem.  Men should ensure that their testosterone free and total, estradiol and other hormone factors are within normal levels. One of those hormone tests to monitor is the Sex Hormone Binding Globulin (SHBG) test.   SHBG and the Free Testosterone Relationship   When our body produces testosterone or provides it exogenously, a set level of testosterone flows through the body. This testosterone blood level can be measured precisely through a simple blood test aptly referred to as the Total Testosterone blood test. For most adult men, when testing their total testosterone, if it falls in the 350 ng/dl to 1100 ng/dl range, this will be considered medically optimal. Such individuals, even exhibiting low testosterone symptoms, will often not be prescribed TRT. In some cases, this may be a correct diagnosis; in other cases, symptoms exist for different reasons, but in most cases, something else is at play, which makes SHBG important.   While useful, measuring total testosterone is only useful with also measuring Free Testosterone. Free testosterone is a small fraction of your total testosterone. It is often referred to as "unbound," meaning the testosterone your body will use for its intended androgenic function. Free testosterone is so important that if your total testosterone levels are within range, if free testosterone levels are low, in most cases, the man will be symptomatic of low testosterone. This issue is often due to high levels of SHBG in the body.   For this reason, many men will attempt to lower their SHBG or even fret over it. However, SHBG serves an essential purpose. As is with estrogen, too much can be problematic, but so can too little. SHBG is no different.   Of all the testosterone flowing through your body, only 2% is what we can refer to as unbound or free testosterone. From a layman's perspective, to increase free and unbound testosterone, they'd need to increase their total testosterone. Unfortunately, it doesn't always work that way – it often helps and often fixes the issue, but not always – and here's why: our testosterone is bound to albumin and sex hormone-binding globulin (SHBG). Approximately one-third of total testosterone binds to albumin, and the rest to SHBG.   Albumin is a protein that binds testosterone, and we can say it does so loosely. This protein carries testosterone through the bloodstream and releases it as needed. The testosterone detaches and becomes what's often referred to as bioavailable or free testosterone. The testosterone that separates from albumin becomes the testosterone that influences your body's functions from sex organs, muscle tissue, brain function, and a host of other areas of bodily function. Testosterone attached to SHBG cannot do this; it is attached and does not detach.   What Causes High SHBG?   As testosterone attached to SHBG is relatively useless, if SHBG levels increase within the body, there will be more attaches and less free testosterone to circulate. Conversely, lower levels of SHBG are associated with higher levels of free testosterone, which is often associated with positive influences on bodily functions, such as libido, mood, muscle mass, etc.   Numerous factors influence how much sex hormone-binding globulin we have in our bodies. Age is one of the primary factors that affect SHBG. Often as we age, SHBG levels increase, and as a result, free testosterone levels go down. Even if our total testosterone levels remain high or optimal, our bioavailable testosterone decreases if SHBG levels increase.   Other factors that can contribute to high SHBG include: Fatty Liver Excessive or what we might call chronic alcohol consumption can lead to a fatty liver and impending higher levels of SHBG and corresponding lower levels of free testosterone. The disease can also be a factor, such as cirrhosis or cancer. Thyroid issues An underactive and overactive thyroid can lead to elevated SHBG, not to mention issues associated with the thyroid. Overactive thyroid or hyperthyroidism is often associated with graves' disease, thyroid nodules, or thyroiditis. It can also exist due to abuse of thyroid medications, such as Cytomel (T3). Underactive thyroid or hypothyroidism may be caused by inflammation of the thyroid gland, pituitary damage, too little iodine in the diet, or genetic factors, along with other possible reasons. Elevated estradiol High levels of estradiol can occur for numerous reasons, which are not limited to using certain antibiotics, some mental health medications, obesity, and abuse of exogenous testosterone. Obesity & High triglycerides While not as expected of a factor for increasing SHBG, being overweight with a low lipid profile can negatively impact. Inflammation While some level of inflammation is necessary for general health in the fight against disease or injury, what we might call chronic inflammation can lead to increases in SHBG and corresponding lower levels of free testosterone   Get Your Levels Checked: SHBG Test, Free & Total Testosterone Test   Testing your SHBG levels along with both total and free testosterone is particularly important if one wants to get to the bottom of hypogonadism (low testosterone) symptoms they may be experiencing. Remember, a total testosterone test alone, which some physicians will run, is not enough. For most adult men, SHBG levels will run between 10 nmol/L and 60 nmol/L if in the optimal range. If SHBG levels are greater than 60 nmol/L and your free testosterone is less than 2% of your total testosterone, there is a good chance your SHBG levels are too high.   Discounted Labs sells several lab test panels that measure SHBG levels that you can buy without a doctor's visit:   Testosterone (Total and Free), SHBG, CBC - Hematocrit, Ultrasensitive Estradiol and PSA   Testosterone, Free, Bioavailable and Total (Upper Limit T 1,500 ng/dL) plus SHBG   CBC, CMP, TT, FT, Lipids, Prolactin, Ultra-Sensitive Estradiol, and SHBG   Testosterone, Free, Bioavailable, and Total, LC/MS (No Upper Limit) plus SHBG   As we now understand SHBG, our next question is what can be done to lower it, increasing free testosterone in the body? There is nothing we can do about aging. As each day passes, we grow older, but there are still things we can do that will improve this factor.   How to Lower SHBG Levels:   The most obvious answer to the problem of low free testosterone and high levels of SHBG is to increase testosterone. Exercise more, consume a cleaner diet, and lose weight; all of these things will increase your testosterone levels. Your levels may not increase massively, but some increase means a higher total to pull from and a greater amount of free testosterone based on the 2% fraction. If this isn't enough - perhaps you're not reaching a 2% fraction due to elevated SHBG – one may need to consider talking to their doctor about testosterone supplementation. However, even if supplementing with exogenous testosterone, the habits mentioned are good for overall health and can only have a positive impact.   Another possible solution, and one of the more commonly needed, is lowering estradiol levels in the body. We tend to think estrogen hormones are needed for females only, but they are also crucial for men, granted in smaller amounts. As it pertains to estrogen, too much estradiol can lead to elevated levels of SHBG. If testosterone levels are also low, this can lead to even more negative factors. But it's important not to get carried away as estradiol that's too low will bring with it numerous symptoms; in fact, your life could be miserable in that regard.   Many men who are at least somewhat familiar with testosterone have been wrongly been told that too much testosterone can lead to gynecomastia due to elevated levels of estrogen in the body due to the aromatization of testosterone to estrogen. But low levels of testosterone in the body with present high levels of SHBG and estradiol can have the effect of causing gynecomastia. In order to combat high levels of estradiol, avoiding certain foods, especially those that are soy-based, will be important. Equally important is living a healthy lifestyle and incorporating what was mentioned above: adequate exercise, a healthy diet, and getting enough sleep. These things will help lower estradiol. Some men will also need medical help through medications known as aromatase inhibitors if they have gynecomastia, although most men on TRT do not need an AI. Too many men have relied on aromatase inhibitors out of fear for too many years. In reality, most men who supplement with exogenous testosterone can, in fact, control estrogen via non-medicated factors.   Some studies have shown that supplementation with DHEA (Dehydroepiandrosterone) may also lower SHBG. However, more study is needed to understand this properly, as too much DHEA can prove problematic. High doses of DHEA supplements have been associated with increased estradiol, so you must speak to your doctor first before beginning such a supplementation regimen.   Very Low SHBG :   We are then left with one factor we've yet to discuss much because it isn't all that common: low SHBG, or rather, levels of SHBG that are too low. Levels of SHBG that are too low may be an indicator of other underlying health issues. This may be an indicator of a metabolic problem. Low levels of SHBG are a standard indicator of those with diabetes. It doesn't appear, as data suggests, that insulin resistance is caused by low SHBG, but it may be a useful marker. More data is currently needed on this topic.   An A1c test will be needed to know with certainty in terms of your diabetic health.   While low SHBG is not a common concern for most men, new data has produced interesting results and information. A recent study published in the Journal of Clinical Endocrinology and Metabolism provides such information.   The process showed a man with undetectable levels of SHBG and low levels of testosterone accompanied by nearly a decade of hypogonadism symptoms. They discovered a family with a missense mutation in the SHBG gene from studying this individual. Interestingly enough, they found this issue did not interfere with the individual's spermatogenesis or general gonadal development. This leads the study to conclude SHBG may not play a significant role in the maturation of the male species physiologically or sexually.   More interesting than the JCEM study is things that new data suggest may negatively impact all men. Low levels of SHBG have recently been associated with three medical conditions that are known to be the silent killers of many men: heart disease, metabolic syndrome, and diabetes. Again, currently, it is being viewed as a marker and not as direct causation, but this new information is important as it acknowledges that more studies must be done.   Low SHBG has also been associated with:   Obesity Obesity is a factor we all well understand and is an issue that leads to problems in many health areas, and often in numerous possible directions. Cushing Disease It is associated with extended exposure to high levels of cortisol. Hypothyroidism It is associated with an under-active thyroid. Excessive levels of growth hormone Exceedingly rare for most, although possible via genetic factors or abuse of exogenous forms. Abuse through anabolic steroids     Is SHBG an Enemy of Hormone? - Emerging Studies   As we mentioned, androgens like testosterone and DHEA and estrogens are transported to the sex hormone binding globulin (SHBG). SHBG is believed to keep sex hormones inactive and to control the amount of free hormones that enter cells by passive diffusion. Contrary to the free hormone hypothesis, some researchers have demonstrated that megalin, a receptor in ovaries and testicles, acts as a pathway for cellular uptake of biologically active androgens and estrogens bound to SHBG. We will see more data on this newly found receptor that actually enables the body to use hormones bound to SHBG in the near future.   In endocrinology, the body has no “harmful” or “good” hormone. Their balance and harmony with each other matters for the best health.     References:   Ding et al. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. The New England Journal of Medicine. Aug 2009. Vos et al. Sex Hormone Binding Globulin Deficiency Due to a Homozygous Missense Mutation. Journal of Clinical Endocrinology and Metabolism. Sept 2014 SHBG and Free Testosterone - Everything You Need to Know Hammes et al. Role of Endocytosis in Cellular Uptake of Sex Steroids. Cell. Sept 2005  

Estradiol in Men: What is the Most Accurate Blood Test? Table of Contents Estradiol in Men: What is the Most Accurate Blood Test? Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men Objective: Design and Setting: Main Outcome Measures: Results: Conclusions: BUY SENSITIVE ESTRADIOL TEST HERE  Recent studies show the importance of estradiol in men and how low estradiol can be detrimental for not only for bone but also for sex drive. Low estradiol has also been linked to fat gain. So, physicians should be careful about treating men who are obviously being over diagnosed with high estradiol due to the use of the wrong test. This study compares the old estradiol blood test assay (ECLIA) to the more accurate sensitive one (LC/MS/MS). The sensitive estradiol test is a method for measuring estradiol levels in men (and children) using a sensitive liquid chromatography-tandem mass spectrometry (LC/MS)-based assay[2]. It is considered more accurate for men because it provides better sensitivity and accuracy at lower estradiol concentrations, which are typically found in men, as opposed to higher concentrations found in adult females[1][2]. Immunoassay-based estradiol tests, on the other hand, perform best at higher concentrations of estradiol, making them more suitable for individuals with levels in the adult-female range[2]. The sensitive estradiol test, with its greater sensitivity at lower levels, is more appropriate for men who generally have lower levels of estradiol compared to adult females[3]. Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men  (Source: The Journal of Clinical Endocrinology & Metabolism, Volume 98, Issue 6, 1 June 2013, Pages E1097–E110)   Immunoassay-based techniques, routinely used to measure serum estradiol (E2), are known to have reduced specificity, especially at lower concentrations, when compared with the gold standard technique of mass spectrometry (MS). Different measurement techniques may be responsible for the conflicting results of associations between serum E2 and clinical phenotypes in men. Objective: Our objective was to compare immunoassay and MS measurements of E2 levels in men and evaluate associations with clinical phenotypes. Design and Setting: Middle-aged and older male subjects participating in the population-based Osteoporotic Fractures in Men (MrOS) Sweden study (n = 2599), MrOS US (n = 688), and the European Male Aging Study (n = 2908) were included. Main Outcome Measures: Immunoassay and MS measurements of serum E2 were compared and related to bone mineral density (BMD; measured by dual energy x-ray absorptiometry) and ankle-brachial index. Results: Within each cohort, serum E2 levels obtained by immunoassay and MS correlated moderately (Spearman rank correlation coefficient rS 0.53–0.76). Serum C-reactive protein (CRP) levels associated significantly (albeit to a low extent, rS = 0.29) with immunoassay E2 but not with MS E2 levels. Similar associations of immunoassay E2 and MS E2 were seen with lumbar spine and total hip BMD, independent of serum CRP. However, immunoassay E2, but not MS E2, associated inversely with ankle-brachial index, and this correlation was lost after adjustment for CRP (C Reactive Protein- An Inflammatory marker). Conclusions: Our findings suggest interference in the immunoassay E2 analyses, possibly by CRP or a CRP-associated factor. Although associations with BMD remain unaffected, this might imply for a reevaluation of previous association studies between immunoassay E2 levels and inflammation-related outcomes. BUY SENSITIVE ESTRADIOL TEST HERE   

Table of Contents Testosterone Fractions in Men How SHBG Influences Free Testosterone What Factors Influence Your SHBG Levels? How Do You Know if Your SHBG Levels Are High? How to Lower SHBG and Automatically Increase Free Testosterone Levels? Raise Your Total Testosterone Level Lower Your Estradiol Levels DHEA Supplements Might Help What if My SHBG Levels Are Already Low? Now You Know More About SHBG and the Role It Plays in Your Body!   When people hear about testosterone, they immediately think about muscles, alpha males, confidence, and probably sports cars. This is the most important male sex hormone and one of the most important hormones in the human body. However, this hormone has several fractions. It is influenced by your lifestyle and it can influence how you think and how you feel. For example, too much sex hormone-binding globulin (SHBG) can decrease free testosterone which can lead to low libido and other symptoms.  That is why some men search for ways to decrease SHBG levels. If you are interested in testosterone fractions and how to naturally increase this sex hormone in your body then keep reading. You will find out more about the bioavailability of testosterone and why it plays a vital role in your health. You will also find out how to decrease SHBG levels. Testosterone Fractions in Men If you do a testosterone test, your doctor will mention your average levels. For example, the generally accepted healthy levels of testosterone for men are between 350 ng/dl and 1,100 ng/dl. If you have a total testosterone level under 350 ng/dL, you might be diagnosed with hypogonadism (testosterone deficiency). However, this is the total testosterone level in your bloodstream. This hormone is made up of several fractions and they are important too. For example, there are bound testosterone (bound) and free testosterone (non-bound) levels that circulate through your blood. Total testosterone is made up of these two types of testosterone. Free testosterone makes up for about 2% of your total testosterone levels. This is the one that goes to your muscles, brain, and influences other organs and tissues in your body. The bound testosterone usually attaches to two substances - albumin or SHBG. The amount of testosterone that is bound to albumin is about a third of your total testosterone. The amount of testosterone that is bound to SHBG is approximately two-thirds of your total testosterone. Albumin is a protein and it carries your testosterone through the bloodstream and releases it as it is needed. You often hear the term "bioavailable testosterone". This refers to the amount of testosterone that can be used by your body. Luckily, testosterone bound to albumin can detach if necessary and get used as free testosterone. The one bound to SHBG cannot do that. In this case, the bioavailable testosterone in your body is the sum of free testosterone and albumin-bound testosterone. How SHBG Influences Free Testosterone It's a well-known fact that the levels of albumin in your blood are generally stable. This protein doesn't have massive spikes in quantity for a male adult. On the other hand, SHBG levels can increase and decrease based on various factors. Most importantly, the levels of SHBG influence how much free testosterone you have in your blood. High levels of SHBG are usually associated with low levels of free testosterone. Less testosterone is available for muscles, the brain, and organs. The vice-versa is also true. Lower levels of SHBG are associated with higher levels of free testosterone. This can positively influence your mood and libido. What Factors Influence Your SHBG Levels? Multiple types of factors influence how much SHBG there is in your bloodstream. Aging is one of the most important factors.  As men age, their SHBG levels will naturally go up while the free testosterone levels will go down. However, you can do something about the other factors. For example, liver problems can increase SHBG levels in men of all ages. If you have a fatty liver due to chronic alcohol consumption or other reasons, chances are that your SHBG levels are also higher than normal. This is true for other liver problems such as cirrhosis or cancer. Thyroid problems can also increase SHBG levels. If your thyroid gland is less active or hyperactive, you might start to feel the symptoms of this health issue. Too much estradiol in your body is also responsible for increasing SHBG levels. Obesity and high triglyceride levels are commonly associated with an increase in SHBG levels in the blood. If you are overweight and your lipid profile is not very good, chances are that your overall testosterone levels might drop. Finally, inflammation is another factor that could increase SHBG levels and decrease free testosterone ones. Acute inflammation is good for the body to help you fight diseases. Chronic inflammation, on the other hand, can lead to life-threatening issues and raise your SHBG levels. How Do You Know if Your SHBG Levels Are High? A simple blood test provides the best opportunity to test your testosterone levels accurately. Medical technology got very advanced, and it's possible to find out exactly how much testosterone is flowing through your blood quickly and safely. However, remember that most tests will communicate your total testosterone levels. You should dig a little bit deeper and find out the exact SHBG and free testosterone levels. These are the ones that interest you the most in this case. If the percent of total testosterone that is free testosterone is below 2 percent, then you may have high SHBG. For example, the optimal SHBG levels in adult males are between 10 and 60 nmol/L. If you have more than that, chances are that your free testosterone levels are also smaller than normal. Ask your doctor for assistance if you cannot figure out the SHBG levels independently. Discounted Labs sells several tests, including the SHBG test as part of lab test panels.   How to Lower SHBG and Automatically Increase Free Testosterone Levels? Now that you have learned more about SHBG and how it can influence your body, the next obvious question is to find out a way to decrease SHBG levels. You cannot stop the aging process, but you can do something about the other factors that influence SHBG. Raise Your Total Testosterone Level This is the simplest and often the best method to reduce SHBG and increase free testosterone. If your testosterone levels are low, do something to increase them. For example, you can lose weight, start exercising more often and clean your diet of junk food and processed meals. This will automatically increase your total testosterone level. A fraction of this level is free testosterone, but it's a fraction of something larger than before, so you'll definitely experience its positive effects. Lower Your Estradiol Levels Another way you can reduce your SHBG levels is by lowering the number of estrogens in your body. Estrogens are the maprimaryemale sex hormones but are also needed by the male body. One of the most important estrogens is estradiol. Men have small amounts of estradiol too, but too much can lead to high SHBG levels and even gynecomastia if low testosterone is present. Lowering estrogen levels is possible for men of all ages. For example, you should avoid soy-based products as these have the tendency to increase your blood estrogen levels. At the same time, try to minimize alcohol consumption, exercise more, lose weight if you are overweight, and get plenty of sleep. DHEA Supplements Might Help DHEA or dehydroepiandrosterone, is one of the most abundant steroids in the human body. It's a weak estrogen and androgen hormone. It serves many purposes in the body and it can be sold as a supplement. Some studies show that small doses of DHEA administered to men might decrease SHBG levels. However, more research is needed as increasing the levels of DHEA in the body can have serious side effects in the long run. For example, high levels of DHEA are commonly associated with Parkinson's Disease. This complex neurodegenerative disease can lead to memory loss and poor brain function. If you decide to take DHEA supplements, make sure that you speak with your doctor first. Remember that these solutions might work for people with SHBG levels higher than normal. If your SHBG level is low, you should not worry about lowering it further. What if My SHBG Levels Are Already Low? In this case, your free testosterone levels are optimal and you don't have to do anything to increase them. However, more SHBG is needed too. This could signify an underlying health condition that must be explored further. For example, if you have low SHBG in your bloodstream, you might have a fatty liver or metabolic syndrome. This condition can be caused by excessive alcohol consumption or other factors. A liver problem is usually associated with insulin resistance too. Generally speaking, low SHBG levels are good predictors of diabetes in people of all ages. You must do a blood glucose and a A1c test to see how glucose is processed in your body. If you're pre-diabetic, you can still do something to increase insulin sensitivity and avoid this chronic condition. Now You Know More About SHBG and the Role It Plays in Your Body! Although deciphering the mysteries of testosterone and SHBG is not easy, major medical advancements are made each day. As you can see, too little SHBG is bad, but too much of it is not good either. Patients must aim for an optimal level of SHBG and monitor it closely using a SHBG blood test.    

Table of Contents The 6 Most Popular Discounted Lab Panels Online Why Using Direct-to-Consumer Labs? How Do Online Lab Tests Work? What Lab Tests Can You Choose? What Are the Most Popular Blood Tests Online? 1. Heavy Metal Test Symptoms of Heavy Metal Poisoning 2. Hormone and Wellness Panels for Men and Women 3. Comprehensive Fatigue Panel 4. Erectile Dysfunction ED Panel 5. Electrolyte Panel 6. Elite Male Blood Test Panel Get Your Blood Test Today! The 6 Most Popular Discounted Lab Panels Online   According to the World Health Organization, chronic diseases kill millions of people each year. Diabetes alone accounted for nearly 1.6 million deaths in 2015. Deaths caused by neurodegenerative diseases such as dementia doubled since 2000, and this number is expected to grow in the upcoming years. Although these are alarming facts, you might be happy to find out that numerous diseases and injuries, particularly chronic illnesses, can be prevented. To prevent a disease, you first need to be aware of it. To be aware of it, you need to do the right thing and get your health checked periodically. Discovering a predisposition to the disease earlier on gives you a massive advantage. You’ll be able to follow special treatments and minimize its risks or eliminate them. But how to get tested for various diseases which might affect you? Well, one of the simplest and most efficient ways is by using direct-to-consumer labs. These are usually discount labs you can purchase online at affordable prices and have your general health checked in a matter of days. Why Using Direct-to-Consumer Labs? Direct-to-consumer labs are discounted labs sold by various companies such as DiscountedLabs.com. Many people decide to buy their lab tests instead of working with their primary physicians because this route offers numerous advantages. For example: You can choose your preferred test from hundreds of labs available online You save money since you eliminate the middle man and buy "directly from the source” and not having to pay for a doctor’s visit copay. You get your results back in just a few business days.  Your information and results are confidential and secure You can draw blood or offer a urine sample in the nearest clinic from your house You have more control over your health More and more people are taking advantage of this opportunity to buy a cheap blood test and become more aware of their health, so why shouldn’t you? How Do Online Lab Tests Work? Getting a blood test online is not rocket science. The procedure has just a few steps: 1. Order your preferred test from DiscountedLabs.com 2. Get a form which allows you to go to the nearest lab or clinic to draw blood that you can download after your purchase. 3. Have your blood samples analyzed by a Quest Diagnostics laboratory in your state or the nearest state. 4. The results will be available for you to download in 5-7 business days from the day of your lab blood draw. 5. You can visit your doctor to help you interpret these results or compare them against reference values you find online As you can see, the process is simple, confidential and secure. You don’t even have to visit your doctor for a prescription since DiscountedLabs.com provides that for you. What Lab Tests Can You Choose? There are numerous things you can test in a human body using just a blood, urine or saliva sample. For example, some of the most popular tests include a complete blood count test which tells you how much hemoglobin there is in your blood, the number, and type of your blood cells, etc. You can also go for a pregnenolone test or a cheap testosterone test to determine your testosterone levels. Cheap blood tests are also available, and they can show information about your cholesterol levels, triglycerides, inflammation biomarkers and more. Buying a testosterone test online is increasingly popular especially if you’re a bodybuilder and you want to monitor your T levels or if you think you have testosterone deficiency. DiscountedLabs.com offers dozens of affordable tests for both men and women, so you have a lot of options at your disposal when it comes to taking care of your health. What Are the Most Popular Blood Tests Online? If you’re buying for the first time and you don’t know what to focus on, keep reading to find out a list of some of the most popular direct-to-consumer labs you can buy today. These tests can be obtained using a discounted labs coupon to help you save some money in the process. Here is a way to compare all discounted lab panels to see which one is best for you. 1. Heavy Metal Test The dangers of having heavy metals in your body are real. The heavy metals category includes mercury, arsenic, cadmium, lead and other types of toxic substances. These elements can stick to your bones and organs, causing serious health problems in the long run. The body can easily eliminate trace amounts of heavy metals regularly. However, if you get too high of a quantity of arsenic, for example, you're exposed to serious health risks. Lead is one of the most poisonous heavy metal out there. It can cause brain damage, depression, anxiety, and even panic attacks. Testing for heavy metals can be done using a single blood sample or a urine sample. The Heavy Metals Profile I is performed using a blood sample, and it determines the levels of arsenic, mercury, and lead in your body. There are two more tests sold by DiscountedLabs such as the heavy metal profile II and the urine test. These also come at affordable prices and allow you to discover the levels of cadmium, lead, and arsenic in your system. Symptoms of Heavy Metal Poisoning Having a high amount of toxic metals in your body puts you in a risky situation, so you need to see your doctor immediately if this happens. Moreover, you’ll be able to experience certain symptoms along the way, and you shouldn’t ignore them. These symptoms depend on the type of metal which caused the poisoning. For example, these symptoms are common among people: l Stomach pain l Diarrhea l Nausea l Dizziness l Tingling in your feet l Weakness and headaches l Vomiting Some of these symptoms are your body's desperate attempt to eliminate the accumulated heavy metals. Help your body by getting tested for heavy metals immediately and find out if you're at risk. 2. Hormone and Wellness Panels for Men and Women Any hormonal imbalance you might experience can drastically influence your health. For example, testosterone deficiency can lead to poor sex drive and even symptoms of anxiety and depression in men of all ages. Instead of looking for “testosterone testing near me” on Google, you can order a testosterone test online and have your hormonal levels checked quickly. In women, estrogen levels are the most important. One of the most popular estrogens is estradiol. This hormone directly influences mood, cognition, sex drive, libido, and other functions in women. It is also possible to check the estradiol levels for men and see if they are elevated. Very high estradiol levels in men might be caused by testosterone replacement therapy. This is a rare but known side effect of TRT, but it can be minimized with certain medications. Another common side effect of TRT has high hematocrit. If you’re wondering what high hematocrit mean then you should know that this is the percentage of red blood cells in the blood. An elevated hematocrit might cause various health problems in the long run. Donating blood can be the answer if you’re wondering how to lower hematocrit on TRT, donating blood can be the answer. However, you shouldn’t donate blood more often than one or two times per year because this can lower your ferritin levels which causes anemia. There are high hematocrit symptoms to which you should pay attention. For example, having high hematocrit levels can lead to: l Fatigue l Itching l Bone pain l Blurred vision l Excessive sweating As you can see, there are numerous important hormones you need to be mindful of such as testosterone, estrogen, estradiol, ferritin, etc. A complete hormone and wellness panel can make your life easier because it provides a complete overview of your health. DiscountedLabs.com sells a Complete Hormone & Wellness Panel for MEN and a Hormone & Wellness Panel for WOMEN, so pick the one suitable for you to learn more about your hormonal health. 3. Comprehensive Fatigue Panel If you feel tired after a long day at work, it’s normal to be so, especially if you also found some time to visit a local gym for half an hour. However, if you constantly feel tired, even in the morning when you wake up, then this is not normal. Diagnosing excessive fatigue is not that easy. There are numerous potential causes which need to be analyzed independently. For example, here are a few factors which might directly influence your energy levels and how tired you feel regularly: l Your thyroid function l Whether you have hyperglycemia or hypoglycemia l Your total and free testosterone levels l The amount of iron in your blood cells l The number of red blood cells in the blood l Any adrenal problems you might have One hormonal imbalance in these areas can make you feel excessively tired. Also, keep in mind that such health problems don’t get corrected on their own. You need to do a thorough health checkup and see what causes your tiredness. A comprehensive fatigue panel takes all these factors into account and analyzes multiple hormones and substances in your bloodstream. Based on the results, your doctor can make appropriate health recommendations. For example, people who have low energy levels as a result of insufficient iron in their bloodstream might need to take an iron supplement. Similarly, those who have low testosterone levels might benefit from TRT or various lifestyle changes to improve their total and free testosterone levels. 4. Erectile Dysfunction ED Panel Another commonly purchased panel is the ED blood test. Unfortunately, the prevalence of erectile dysfunction is quite high, especially among men who are 40 years old or older. However, this health condition can be treated in numerous ways. There are both invasive and non-invasive procedures as well as pills which can improve the symptoms of erectile dysfunction. Certain lifestyle changes can also improve one's erection. However, the most important thing is to know exactly what caused the ED and how to treat it efficiently. For example, having low testosterone levels can lead to erectile dysfunction in men of all ages. In this case, TRT might be the appropriate treatment method to improve libido. Similarly, high estradiol can also be linked to erectile problems. Estradiol is a female sex hormone. If there is too much (or even too little) estradiol in the bloodstream, the person in question will experience erectile dysfunction. ED can also be caused by thyroid problems. For example, the TSH, T3, and T4 are all thyroid hormones which directly influence the production of testosterone and sex drive in general. If these hormones are out of balance, one might not be in the mood for sex that often. Prolactin is another important hormone in the body. It is produced by the pituitary gland, and if it’s not secreted correctly, ED can appear in men. As you can see, there are numerous factors which influence sex drive. The Erectile Dysfunction Panel which can be bought from DiscountedLabs.com looks at all these hormones to determine which one is out of balance. All you need to do is to buy the panel online and go to your nearest lab for a blood sample. The results will be communicated to you in a few business days, and then you can begin looking for appropriate solutions to your ED problem. 5. Electrolyte Panel Electrolytes are important substances in the human body. The most popular ones are potassium and sodium. Other electrolytes include chloride and carbon dioxide. The job of electrolytes is to regulate important bodily functions such as maintaining correct blood pH, muscle and nerve function. When electrolytes go out of balance, various physical symptoms can appear. For example, too much sodium in the body makes the blood acidic. This can lead to chronic illnesses in the long run. At the same time, too much potassium can cause heart problems and other similar health conditions. The Electrolyte Panel which can be bought from DiscountedLabs.com looks at four different important electrolytes in the body such as carbon dioxide, chloride, potassium, and sodium. This is one of the most affordable blood tests online, and it requires only a small blood sample to run it. 6. Elite Male Blood Test Panel If you want to have a broader overview of your health, the Elite Male Blood Test Panel is highly recommended for you. This is one of the most comprehensive panels sold on DiscountedLabs and one of the most affordable in the United States. Using just a simple blood sample, you get to find out more information about multiple hormones, enzymes, and substances in your body such as testosterone, prolactin, thyroid hormones, IGF-1, PSA and more. This panel looks at more than ten different hormones in your bloodstream, helping you diagnose certain conditions or preventing more serious diseases. A lipid panel is also included in this package, revealing information about your good cholesterol, bad cholesterol, and triglyceride levels. Another important hormone checked by this panel is sensitive estradiol. This hormone is linked to sex drive, and if it is in high quantities, it can lead to gynecomastia which is also known as “male boobs.” The estradiol levels might increase as a result of testosterone replacement therapy. If you’re currently using TRT, you might want to get this panel to find out if you’re prone to develop gynecomastia in the future. The Elite Male Blood Test Panel also looks at your complete blood count. It analyzes your hematocrit, the number of red blood cells, the amount of hemoglobin in your bloodstream, etc. Knowing more information about red blood cells helps you determine if you’re predisposed to anemia. Similarly, having a high hematocrit can cause problems in the long run so that you can monitor this important parameter with the Elite Male Panel. Another important aspect checked by this panel is the metabolic function. More precisely, the test looks at the kidney and liver health. As you probably already know, your liver is one of the most important organs in the body. It is responsible for eliminating toxins and producing numerous hormones required for a healthy living. Once you know the state of your liver, you'll be able to make appropriate lifestyle changes to improve its function. The same story goes for your kidneys. For example, creatinine is a byproduct which needs to be excreted by the kidneys. If this process doesn't happen correctly, you can develop kidney problems in the future. The Elite Male Blood Panel helps you look at all these vital aspects and have a broader understanding of your health. Get Your Blood Test Today! As you can see, ordering direct-to-consumer labs is efficient, more affordable and saves time. You don’t have to search for “discounted labs tests near me” on Google anymore; the answer comes directly from DiscountedLabs.com.  

Testosterone replacement therapy is an important treatment option for men with low testosterone and symptomatic hypogonadism. Various formulations of exogenous (supplemental) testosterone replacement therapy exist, including oral, buccal, intramuscular, transdermal, subdermal, and nasal preparations. However, exogenous testosterone replacement therapy is a double-edged sword, posing risks to fertility due to negative feedback mechanisms on the hypothalamic-pituitary-gonadal (HPG) axis, which is the primary regulator of testosterone production and sperm production in men.  Testosterone replacement therapy (TRT) is one of the most effective ways to combat low testosterone levels, but you must understand the risks associated with the treatment. As with any hormone replacement therapy, there are a few downsides to receiving regular testosterone injections. But do these risks outweigh the benefits? That’s a decision you’ll have to make for yourself!   Testosterone replacement therapy- Target Blood Test Limits: To minimize TRT side effects, different medical guideline groups have created lab test value ranges and maximum acceptable targets . These values have been collected from three TRT guidelines and clinical practices around the United States: Hematocrit (percent of red blood cells in plasma) under 53 PSA (Prostatic specific antigen) under 3 (4 is max since doctors will not prescribe TRT at this number) Estradiol (sensitive) between 20-50 pg/mL. However, if you have high testosterone, estradiol will be "high" per Quest or Labcorp since 0.4% of total testosterone aromatizes to estradiol. Blood pressure under 135/85 Estimated Glomerular (eGFR) (kidney function) over 60 Liver enzymes not elevated over 20 percent of top value of reference range Total Testosterone over 450 ng/dL Free Testosterone equal or above 2 percent of total If donating blood to bring hematocrit down, ferritin should never under 30 ng/mL or micrograms/liter (this could lead to fatigue) Free T3 (if hypothyroid and on treatment) in the upper quartile of range. (depending on range it can be 3.7- 4.2 pg/mL) HDL over 40 mg/dL (higher TRT doses can lead to decreased HDL cholesterol) You can order these lab tests here: TRT Male Hormone/Wellness Follow-Up Panel PSA Lipid Panel Thyroid Panel    

The internet is full of information on various subjects, but you probably already know that you have to carefully select your health information source. For example, if you're looking for information about men’s health and testosterone replacement therapy, Excelmale.com is probably your safest bet. Table of Contents Join a Growing TRT Forum of Almost 40,000 Members Topics Covered Include TRT, HCG, Erectile Dysfunction, Nutrition, and More Take Advice from Fitness and Nutrition Experts, Dietitians, Medical Doctors, and More Get Educated Through Men’s Health Videos, Articles, Podcasts, Scientific Papers, and More There Is a Dedicated HRT Section for Women Too Best of All - It's Free to Register! A lot of myths and disinformation usually surrounds these subjects. You might end up confused if you're trying to learn about TRT from the wrong places. On the other hand, if you go to the Excelmale.com forum, you can access scientifically proven data and experts' opinions. Created in 2013 by health author and men’s health advocate Nelson Vergel,  ExcelMale.com has become one of the most respected and largest testosterone forums globally. Keep reading to find out what makes Excelmale.com so unique and why you should visit it if you want to learn more about TRT and men's health. Join a Growing TRT Forum of Almost 40,000 Members You might be happy to find out that Excelmale.com is a testosterone replacement forum with a community of almost 40,000 members. This platform is reviewed daily by knowledgeable individuals to moderate it to prevent spamming or abuse carefully. All these people joined Excelmale.com to learn more about male health, fitness, and nutrition. They are real persons with life stories just like yours. You can find so much information on testosterone and other hormonal replacement therapies from people of all ages and different parts of the world. If you're worried about your personal information, then you should relax. This website is monitored continuously and secured with state-of-the-art protection systems. Your information will not be shared, and the moderators carefully check every message to prevent spamming, so you won't be a victim of cyberbullying. Topics Covered Include TRT, HCG, Erectile Dysfunction, Nutrition, and More The broad range of topics covered at Excelmale.com will amaze you. Not only that, this is the best TRT forum you can find on the internet, but you will also learn about the right testosterone TRT test, HCG use to prevent testicular atrophy, TRT side effects, thyroid treatments, PCT, Trimix injections, supplements, exercise, nutrition, and more. The experts who routinely post on Excelmale.com consult scientific papers and journals to give you the most recent and unbiased information out there. You will find out how to interpret some of your bloodwork results, how to optimize your gains, and how to naturally increase testosterone levels. Best of all, the information is conveyed in layman's terms. You will be able to understand the concepts without requiring a medical degree. Nelson Vergel routinely posts the latest information on TRT and other relevant subjects, so you should come back to this TRT forum more often. Take Advice from Fitness and Nutrition Experts, Dietitians, Medical Doctors, and More Most of the members on the Excelmale.com testosterone forums are regular TRT patients or people who are interested in testosterone replacement therapy and anything related to it. However, there is also a plethora of experts regularly posting on this testosterone replacement forum. For example, you might be able to receive advice from experts who work in compounding pharmacies. A compounding pharmacy can create drugs specifically for your needs, helping you get the right dosage at a reduced price. Other experts in nutrition and fitness also post information on how to live a healthier life. Even if you're not thinking of starting TRT soon, the Excelmale.com forum offers a multitude of valuable pieces of advice that can improve your health, so it's worth a visit. Best of all, TRT patients are invited to share some of their results so that others can learn from them. If you're currently under TRT and have a question, you're welcome to post it on the Excelmale.com TRT forum. You can get expert answers from doctors as well as regular solutions from TRT patients just like you. Get Educated Through Men’s Health Videos, Articles, Podcasts, Scientific Papers, and More Some people like to get informed through reading, and others like to watch a video. Many other people also like to listen to podcasts while doing housework. No matter your preferred learning method, you are covered if you visit the Excelmale.com TRT forum. That's because this forum spreads information through multiple channels, including short and long-form articles, eBooks, scientific papers, videos, podcasts, and more. You can watch and read for free, and some of the eBooks provided on Excelmale.com are also free to download. Apart from that, you can also find a transcription of videos for those who prefer to read instead of watching a clip. As the TRT industry is developing, more and more information becomes available to the general public. The Excelmale.com forum is the place where you can find this information and use it to your advantage. There Is a Dedicated HRT Section for Women Too Hormonal replacement therapy (HRT) is increasingly popular in the United States, Canada, and other countries. Although Excelmale.com is mostly a testosterone therapy forum for men, there is a special HRT women section dedicated to female health information. Here you can find more about the latest advancements in hormonal replacement therapy, diagnosis, side effects management, and more. The founders of Excelmale.com don't want women to feel neglected, and they have created this section on the same website. Experts in nutrition, fitness, and endocrinology routinely post articles and videos about hormonal therapies for women. This information could help you if you want to mitigate the effects of menopause or improve the hormonal balance in your body. Best of All - It's Free to Register! You might be happy to find out that it's free to register on Excelmale.com. You have access to all the information presented above with just a few clicks. Even better, you will also receive a free eBook upon registration. This eBook reveals the secrets of how to optimize your testosterone levels! Whether you're an active TRT patient, you're thinking of starting testosterone replacement therapy or want to improve your health, the Excelmale.com forums provide the best place to start. Make sure that you register on ExcelMale.com to join to join the best TRT community online and get weekly updates on the latest news and science on men’s health and productivity.   IMPORTANT: ExcelMale.com is not associated with the site Male Excel. ExcelMale.com was created several years before that site and it is also a trademarked brand.