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Are you concerned about your kidney health? The Cystatin C test may just be a game-changer for you. This simple blood test can help in the early detection of kidney disease, allowing for timely intervention and treatment. In this blog, we will dive deep into what the Cystatin C test is, why it is important to get tested, when to get tested, and how to prepare for the test. We will also answer common questions about the test, such as how it is used, what the results mean, and much more. If you want to take control of your kidney health and make informed decisions, keep reading. Plus, we'll share a valuable resource where you can buy the Cystatin C test at an affordable price. Cystatin C with Estimated Glomerular Filtration Rate (eGFR), Serum Cystatin C, a biomarker for kidney function, offers advantages over traditional markers like creatinine. The Cystatin C test is performed by measuring the level of cystatin C in the blood serum. The test provides a more accurate estimation of the glomerular filtration rate (GFR), which reflects kidney function. Incorporating Cystatin C testing into routine kidney disease screening and monitoring has the potential to improve the diagnosis and management of conditions like chronic kidney disease. By utilizing this cystatin C-based test, healthcare providers can obtain valuable information about renal function without invasive procedures or relying solely on creatinine levels. Cystatin C Test at a Glance The cystatin C test is a highly accurate indicator of kidney function, surpassing traditional tests. Its ability to detect early signs of kidney disease allows for timely intervention and treatment. This test is particularly beneficial for individuals with risk factors like diabetes or high blood pressure. Monitoring cystatin C levels helps track the progression of kidney disease and assess treatment effectiveness. Incorporating the cystatin C test into routine screenings can save lives and enhance overall kidney health. Why Get Tested? Getting tested for cystatin C is important, as it can detect early signs of kidney dysfunction or disease more accurately than traditional markers. Regular testing helps monitor kidney disease progression and guide treatment decisions. Early detection and management can prevent further damage and improve outcomes. When To Get Tested? It is advisable to undergo a cystatin C test if you have risk factors for kidney disease, such as diabetes or high blood pressure. Additionally, if you experience symptoms like frequent urination, fatigue, or swelling in the hands and feet, it is recommended to get tested. Your doctor may also suggest a cystatin C test if you are taking medications that could potentially impact kidney function. If you already have kidney disease or are receiving treatment for it, regular monitoring with a cystatin C test may be necessary. What Test Preparation Needed? The Cystatin C test does not need any specific preparation, but it's essential to inform your healthcare provider about any medications or supplements. Fasting for a few hours prior to the test is recommended, but follow your healthcare provider's instructions for accurate results. What is Being Tested? The Cystatin C test measures the amount of cystatin C, a protein produced by cells and filtered by the kidneys, in the blood. It helps evaluate kidney function and identify potential kidney disease at an early stage. Elevated levels of cystatin C may suggest impaired kidney function. Common Questions About Cystatin C Test What is a cystatin C test, and how does it help detect kidney disease? How accurate is the cystatin C test compared to other tests for kidney function? Who should consider getting a cystatin C test? Are there any limitations or drawbacks to the cystatin C test? How can the results of a cystatin C test be used in diagnosing and managing kidney disease? How does the cystatin C test compare to a creatinine test for kidney function assessment? How is it used? The Cystatin C test is a blood test that measures the cystatin C level in the blood. It aids in assessing kidney function and identifying early signs of kidney disease. When used alongside other tests like creatinine, it provides a more precise evaluation. The results of this test play a crucial role in determining treatment plans and monitoring the progression of kidney disease. When is the Cystatin C test ordered? The Cystatin C test is usually ordered to evaluate kidney function in various situations, including when there are signs of kidney disease, to monitor kidney function in individuals with known kidney problems, and as part of routine check-ups to detect and prevent kidney disease early. Who May Need a Cystatin C Test? The cystatin C test (which also includes estimated creatinine clearance eGFR) can be done along with the creatinine or creatinine clearance test in cases where those tests aren’t appropriate, such as: Patients taking creatine supplements for bodybuilding. These supplements can increase creatinine and decrease creatinine clearance, which can alarm doctors who fear kidney dysfunction. This creatinine increase is not clinically relevant, but running a Cystatin C test can give physicians reassurance and allow the patient to keep taking that effective bodybuilding supplement. In patients with cirrhosis Cases of morbid obesity Malnourishment Reduced muscle mass Since the concentration of cystatin C in the blood will not change due to infection or inflammation and isn’t affected by body weight, drugs, or diet, cystatin C level could be a more reliable indicator of kidney health than creatinine. Testing for cystatin may also be useful to detect kidney disease early when the affected person isn’t experiencing many (if any) symptoms, and other tests like creatinine and eGFR results are normal. What does the test result mean? The test result measures cystatin C levels in your blood. A high level may suggest kidney problems, while a low level usually indicates normal kidney function. It's crucial to consult a healthcare professional for an accurate interpretation of your test result. Is there anything else I should know? The Cystatin C test is a more accurate way to measure kidney function and can detect early signs of kidney disease. No fasting or special preparations are needed for the test, but it's important to discuss the results with your healthcare provider for proper interpretation and guidance. How is an eGFR calculated? The eGFR (estimated glomerular filtration rate) is calculated using the MDRD equation, which factors in variables like blood creatinine level, age, gender, and race. It's important to remember that eGFR is an estimate and may not be completely accurate for every individual. How can my actual GFR be determined? To determine your actual GFR (glomerular filtration rate), a blood test is necessary. The most accurate way to measure GFR is by assessing the level of cystatin C in the blood, which reflects kidney function. It's crucial to consult with a healthcare professional for proper interpretation and understanding of your kidney function based on the test results. Related Tests - A creatinine test measures the level of creatinine in the blood, a marker of kidney function. - The urine albumin test detects albumin, indicating kidney damage. - Glomerular filtration rate (GFR) calculates how well the kidneys filter waste. - The blood urea nitrogen (BUN) test measures nitrogen levels, indicating kidney function. - Kidney ultrasound creates images for further evaluation. Resources What is Cystatin C, and how does it differ from other kidney function tests? Discover the benefits of using the Cystatin C test for kidney disease detection. Learn about the accuracy of the Cystatin C test compared to traditional methods and its potential impact on the early detection and treatment of kidney disease. Find additional information and resources on the Cystatin C test and kidney health at reputable sources such as the National Kidney Foundation and KDIGO. Sources The cystatin c test is an important tool in detecting kidney disease. To learn more about this test, you can refer to reputable sources such as the National Kidney Foundation, the Mayo Clinic, the American Association for Clinical Chemistry, and the National Institute of Diabetes and Digestive and Kidney Diseases. These sources provide valuable information on the test, its purpose, and how it can help in assessing kidney function. Make sure to consult these resources for reliable and up-to-date information. How to Purchase a Low-Cost Cystatin C Test at DiscountedLabs.com The Cystatin C test is a game-changer in kidney disease detection, offering the convenience and affordability of purchasing the test online at DiscountedLabs.com. Early detection is crucial in managing kidney disease, and the Cystatin C test provides a more accurate assessment of kidney function compared to traditional methods like serum creatinine. By ordering the test through DiscountedLabs.com, you can easily access your test results and take proactive steps towards preserving your kidney health. Take advantage of the affordable and convenient option of purchasing the Cystatin C test at DiscountedLabs.com to prioritize your kidney health today.   Conclusion The cystatin C test is a game-changer when it comes to detecting kidney disease. It provides a more accurate measurement of kidney function compared to traditional tests. By measuring the level of cystatin C in your blood, healthcare professionals can assess your glomerular filtration rate (GFR) and identify any potential kidney problems early on. Early detection is crucial for effective treatment and management of kidney disease. If you suspect that you may be at risk or want to monitor your kidney health, consider getting a cystatin C test. At DiscountedLabs.com, we offer affordable and reliable cystatin C testing. Take control of your kidney health today and order your test.    

Testing for menopause is an important method to identify the beginning of menopause. As women approach their menopausal years, they may experience various symptoms that disrupt daily life, such as hot flashes and irregular periods. While some people might be able to diagnose menopause based on these physical changes alone, others require laboratory tests for confirmation. In this blog post, we will delve into the role of menopause tests by discussing common symptoms associated with this phase of life and situations where testing is necessary. We will investigate the different tests used to diagnose menopause, such as measuring FSH levels and estrogen concentration. Furthermore, we will address the challenges involved in interpreting test results due to fluctuating hormonal patterns and emphasize the importance of evaluating consistent trends. Additionally, we'll discuss ruling out other conditions affecting menstruation through thyroid panel analysis or prolactin testing. Finally, we'll introduce at-home menopause testing options that offer convenience without compromising accuracy. Table of Contents: The Role of Menopause Tests Menopausal Symptoms Diagnosing Menopause Situations Requiring Menopause Testing Types of Menopause Tests Follicle-stimulating hormone (FSH) test Estrogen level measurement Luteinizing hormone (LH) assessment Anti-Mullerian Hormone (AMH) analysis Testing Methods & Interpretation Challenges Blood Sample Collection Process Fluctuating Hormonal Patterns Complicating Interpretation Importance of Evaluating Consistent Trends Ruling Out Other Conditions Affecting Menstruation Thyroid Panel for Thyroid Function Prolactin Test Measuring Prolactin Hormone Levels Pregnancy Test (hCG) Determining Pregnancy Status FAQs About Menopause Testing What is the best test to confirm menopause? What does a menopause test tell you? Are menopause blood tests accurate? Conclusion The Role of Menopause Tests Menopause assessments are essential in ascertaining whether a woman's signs are due to menopausal changes or some other medical issue. In most cases, doctors can diagnose menopause based on age, symptoms, and family history. However, in situations like early onset symptoms or after a hysterectomy, menopause testing becomes necessary. Menopausal Symptoms Hot Flashes: Sudden warmth spreading over the upper body. Night Sweats: Hot flashes occurring during sleep. Vaginal Dryness: Decreased estrogen levels lead to thinner vaginal tissue and less lubrication. Mood Changes: Emotional fluctuations such as irritability and depression due to hormonal shifts. Irregular Periods: Changes in menstrual cycle length and flow before they eventually stop altogether. Diagnosing Menopause Doctors can diagnose menopause without laboratory tests by evaluating a woman's age and reported symptoms. If these align with what is expected for someone entering their "menopausal years," further testing might not be needed unless other health problems arise warranting additional investigation. Situations Requiring Menopause Testing There are specific circumstances that warrant further investigation through laboratory tests to confirm menopause: Hysterectomy: Women who have had their uterus removed may still experience menopausal symptoms but will not have periods, making it difficult to determine if they've reached menopause. Early Onset Symptoms: If a woman starts experiencing symptoms before the typical age range for entering menopause (45–55 years), hormone testing can help determine if she's in perimenopause or has another condition causing her symptoms. Hormone Therapy: For women using hormone replacement therapy, doctors might order tests to monitor and adjust treatment as needed based on hormonal levels. Menopause testing helps ensure that any symptoms experienced are indeed related to this natural life stage and not an underlying health issue requiring different management strategies.   Key Takeaway:  Menopause tests are important to confirm if a woman's symptoms are related to menopause or another health issue. Doctors can diagnose menopause based on age and symptoms, but testing becomes necessary in situations like early-onset symptoms or after a hysterectomy. Menopause testing helps ensure that any symptoms experienced are indeed related to this natural life stage and not an underlying health issue requiring different management strategies. Types of Menopause Tests Various tests measure hormone levels that change during the perimenopausal and postmenopausal stages. Various assessments, including FSH (high follicle-stimulating hormone levels), estradiol (estrogen) measurements, luteinizing hormone test and Anti-Mullerian Hormone (AMH) evaluations, are used to gauge hormones that shift throughout the perimenopausal and postmenopausal stages. Follicle-stimulating hormone (FSH) test The FSH is crucial in ovarian development, and its levels increase as women reach menopause. An FSH blood test confirms if a woman has entered menopause. However, fluctuating FSH levels throughout the menstrual cycle can make interpreting single-test results challenging. Estrogen level measurement Estrogen regulates menstruation and fertility. As women age, their estrogen production decreases, leading to signs like hot flashes and dryness in the vaginal area. Measuring estrogen levels through blood tests helps diagnose menopause by identifying reduced hormonal activity. Luteinizing hormone (LH) assessment Luteinizing hormone (LH) regulates the menstrual cycle and ovulation. During menopause, LH levels increase as a response to declining estrogen production. An LH blood test can help diagnose menopause by detecting elevated hormone levels. Anti-Mullerian Hormone (AMH) analysis Anti-Mullerian Hormone (AMH) indicates a woman's remaining egg supply, or "ovarian reserve." A decline in AMH levels correlates with reduced fertility and approaching menopause. An AMH blood test can predict when a woman may start experiencing menopausal symptoms or determine the cause of the early onset of these symptoms. Doctors might perform additional assessments such as a thyroid panel, prolactin test, and pregnancy test (hCG) to rule out other conditions causing irregular menstruation or stopping it completely. These tests help ensure that the menopause related symptoms experienced are indeed related to menopause and not another underlying issue. "Take control of your menopause journey with affordable lab tests from Discounted Labs. Measure hormone levels and diagnose symptoms without a doctor's visit. #menopausetesting #healthcaremadeeasy" Click to Tweet Testing Methods & Interpretation Challenges Getting tested for menopause involves a simple blood sample collection process. However, interpreting the results can be tricky due to fluctuating hormonal patterns. Hormone levels can vary throughout the menstrual cycle, making it difficult to accurately diagnose menopause based on just one test result. Instead, consistent trends over time should be evaluated to confirm menopausal status. Blood Sample Collection Process The process of collecting blood for menopause testing is quick and easy. A healthcare professional will clean the area on your arm where the needle will be inserted and apply pressure with an elastic band to make the veins more visible. A healthcare professional will insert a needle into a vein in your arm, collecting blood in tubes for laboratory analysis. Fluctuating Hormonal Patterns Complicating Interpretation Interpreting menopause test results can be challenging due to fluctuating hormonal patterns. FSH levels may rise in the middle of a cycle, yet then reduce afterwards, illustrating how relying solely on FSH readings could be misleading when attempting to determine menopausal status. As such, relying solely on FSH measurements could lead to false conclusions about whether someone has entered menopause. In addition to FSH, levels of LH and estrogen should also be taken into account when determining if a person has entered menopause. Follicle-Stimulating Hormone (FSH): An increased level of FSH indicates that ovarian development has slowed down or stopped altogether due to decreased estrogen production as women approach menopause. Luteinizing Hormone (LH): LH may be attempting to activate ovarian development, but this could fail if estrogen levels are too low. Estrogen: A decrease in estrogen levels can cause menopausal symptoms like hot flashes and vaginal dryness. Yet, these concentrations can change over the course of a woman's cycle. Importance of Evaluating Consistent Trends Consistent trends over time should be evaluated to confirm menopausal status. This means looking at multiple hormone measurements taken at different points in your menstrual cycle or even across several months. By evaluating consistent patterns instead of isolated results, healthcare professionals can more accurately determine whether you've entered perimenopause or reached full-blown menopause. In addition to tracking hormone levels over time, discussing any changes in menstruation patterns and other menopausal symptoms with your doctor will help paint a clearer picture of where you stand regarding menopause status. If necessary, they may recommend further testing or treatment options such as hormone therapy for symptom relief. Don't rely on home menopause tests; always consult with your doctor for an accurate diagnosis and treatment of menopausal symptoms.   Key Takeaway:  Getting tested for menopause involves a simple blood sample collection process, but interpreting the results can be challenging due to fluctuating hormonal patterns. Consistent trends over time should be evaluated to confirm menopause status, and discussing any changes in menstruation patterns and other symptoms with your doctor will help determine if further testing or treatment options are necessary. Don't rely on home tests; always consult with your doctor for an accurate diagnosis and treatment of menopausal symptoms. Ruling Out Other Conditions Affecting Menstruation Doctors may perform additional tests, such as a thyroid panel, prolactin test, and pregnancy test (hCG), to rule out other conditions causing irregular menstruation or stop it completely. These tests help ensure that the symptoms experienced are related to menopause and not another underlying issue. Thyroid Panel for Thyroid Function A thyroid panel evaluates how well your thyroid gland is working. Imbalances in thyroid hormones can lead to signs and symptoms comparable to those experienced during menopause, like sweating, exhaustion, body weight changes, and fluctuations in mood. Checking levels of TSH, free T4, free T3, and other markers can determine if an underactive or overactive thyroid could be responsible for menstrual cycle disturbances. Prolactin Test Measuring Prolactin Hormone Levels The prolactin test measures the amount of prolactin hormone present in your blood. High prolactin levels may lead to irregular periods or even stop them altogether, causing breast tenderness - all signs commonly associated with the perimenopausal transition. Ruling out elevated prolactin as a potential cause helps confirm whether menopausal symptoms are the primary reason for menstrual changes. Pregnancy Test (hCG) Determining Pregnancy Status Pregnancy can still occur during the perimenopause years. A pregnancy test (hCG) checks for the presence of human chorionic gonadotropin hormone in your blood or urine. If you're experiencing irregular periods and other menopausal symptoms but suspect that you might be pregnant, this test can help rule out or confirm pregnancy as the cause of these changes. Doctors may also suggest a more in-depth assessment if they think other medical issues, like PCOS, endometriosis, or premature ovarian failure, could be contributing to changes in the menstrual cycle. Work closely with your healthcare provider when interpreting results from various diagnostic tests and discussing appropriate treatment options based on individual needs and medical history. Note: Always consult with a qualified healthcare professional before making any decisions about testing or treatments related to menopause symptoms. The information provided here is intended for educational purposes only and should not replace personalized advice from a licensed practitioner.   Key Takeaway:  Doctors may perform additional tests to rule out other conditions causing irregular menstruation or stopping it completely, such as a thyroid panel, prolactin test, and pregnancy test. Checking levels of TSH, free T4, and free T3 can determine if an underactive or overactive thyroid could be responsible for menstrual cycle disturbances. High prolactin levels may lead to irregular periods or even stop them altogether; ruling out elevated prolactin helps confirm whether menopausal symptoms are the primary reason for menstrual changes. FAQs About Menopause Testing What is the best test to confirm menopause? The most reliable test to confirm menopause is a blood test measuring follicle-stimulating hormone (FSH) levels. Elevated FSH levels, along with a history of irregular periods and other menopausal symptoms, can help diagnose menopause. However, hormonal fluctuations may require multiple tests for accurate results. What does a menopause test tell you? A menopause test measures hormone levels associated with ovarian function, such as FSH, estrogen, luteinizing hormone (LH), and anti-Mullerian hormone (AMH). These tests provide information about your reproductive hormone status and help determine if you're approaching or have entered menopause. Are menopause blood tests accurate? Menopause blood tests are generally accurate when performed in a laboratory setting. However, fluctuating hormone levels during perimenopause may require multiple testing sessions for conclusive results. It's essential to consult with your healthcare provider for proper interpretation of lab results. How do doctors test for early menopause? To assess early menopause, doctors typically perform blood tests measuring FSH, estrogen, LH, and AMH levels, along with evaluating patient-reported symptoms like hot flashes or irregular periods. Additional testing may include a thyroid panel or prolactin level assessment to rule out other conditions that could affect menstruation. Conclusion Don't sweat it, ladies - menopause testing can help diagnose and rule out other menstrual conditions. Tests include FSH, estrogen level measurement, LH assessment, and AMH analysis, but interpreting results can be tricky due to hormonal fluctuations. If you're experiencing symptoms or have concerns, talk to your healthcare provider about menopause testing. Stay informed and empowered with credible sources like the Mayo Clinic and ACOG.  

Table of Contents SHBG and the Free Testosterone Relationship What Causes High SHBG? Other factors that can contribute to high SHBG include:   Get Your Levels Checked: SHBG Test, Free & Total Testosterone Test How to Lower SHBG Levels: Very Low SHBG : Low SHBG has also been associated with: Is SHBG an Enemy of Hormone? - Emerging Studies References: Testosterone is the primary and dominant male hormone. It is responsible for numerous functions within the human body in men and women, and when levels are too low, it can lead to multiple health issues. Unfortunately, as many know, testosterone levels naturally decline as we age. Numerous external factors can contribute to lower levels of testosterone. In either case, age or external, symptoms occur, problems arise, and solutions are needed to stop the decline. For many men, testosterone replacement therapy (TRT) is the answer to this problem.  Men should ensure that their testosterone free and total, estradiol and other hormone factors are within normal levels. One of those hormone tests to monitor is the Sex Hormone Binding Globulin (SHBG) test.   SHBG and the Free Testosterone Relationship   When our body produces testosterone or provides it exogenously, a set level of testosterone flows through the body. This testosterone blood level can be measured precisely through a simple blood test aptly referred to as the Total Testosterone blood test. For most adult men, when testing their total testosterone, if it falls in the 350 ng/dl to 1100 ng/dl range, this will be considered medically optimal. Such individuals, even exhibiting low testosterone symptoms, will often not be prescribed TRT. In some cases, this may be a correct diagnosis; in other cases, symptoms exist for different reasons, but in most cases, something else is at play, which makes SHBG important.   While useful, measuring total testosterone is only useful with also measuring Free Testosterone. Free testosterone is a small fraction of your total testosterone. It is often referred to as "unbound," meaning the testosterone your body will use for its intended androgenic function. Free testosterone is so important that if your total testosterone levels are within range, if free testosterone levels are low, in most cases, the man will be symptomatic of low testosterone. This issue is often due to high levels of SHBG in the body.   For this reason, many men will attempt to lower their SHBG or even fret over it. However, SHBG serves an essential purpose. As is with estrogen, too much can be problematic, but so can too little. SHBG is no different.   Of all the testosterone flowing through your body, only 2% is what we can refer to as unbound or free testosterone. From a layman's perspective, to increase free and unbound testosterone, they'd need to increase their total testosterone. Unfortunately, it doesn't always work that way – it often helps and often fixes the issue, but not always – and here's why: our testosterone is bound to albumin and sex hormone-binding globulin (SHBG). Approximately one-third of total testosterone binds to albumin, and the rest to SHBG.   Albumin is a protein that binds testosterone, and we can say it does so loosely. This protein carries testosterone through the bloodstream and releases it as needed. The testosterone detaches and becomes what's often referred to as bioavailable or free testosterone. The testosterone that separates from albumin becomes the testosterone that influences your body's functions from sex organs, muscle tissue, brain function, and a host of other areas of bodily function. Testosterone attached to SHBG cannot do this; it is attached and does not detach.   What Causes High SHBG?   As testosterone attached to SHBG is relatively useless, if SHBG levels increase within the body, there will be more attaches and less free testosterone to circulate. Conversely, lower levels of SHBG are associated with higher levels of free testosterone, which is often associated with positive influences on bodily functions, such as libido, mood, muscle mass, etc.   Numerous factors influence how much sex hormone-binding globulin we have in our bodies. Age is one of the primary factors that affect SHBG. Often as we age, SHBG levels increase, and as a result, free testosterone levels go down. Even if our total testosterone levels remain high or optimal, our bioavailable testosterone decreases if SHBG levels increase.   Other factors that can contribute to high SHBG include: Fatty Liver Excessive or what we might call chronic alcohol consumption can lead to a fatty liver and impending higher levels of SHBG and corresponding lower levels of free testosterone. The disease can also be a factor, such as cirrhosis or cancer. Thyroid issues An underactive and overactive thyroid can lead to elevated SHBG, not to mention issues associated with the thyroid. Overactive thyroid or hyperthyroidism is often associated with graves' disease, thyroid nodules, or thyroiditis. It can also exist due to abuse of thyroid medications, such as Cytomel (T3). Underactive thyroid or hypothyroidism may be caused by inflammation of the thyroid gland, pituitary damage, too little iodine in the diet, or genetic factors, along with other possible reasons. Elevated estradiol High levels of estradiol can occur for numerous reasons, which are not limited to using certain antibiotics, some mental health medications, obesity, and abuse of exogenous testosterone. Obesity & High triglycerides While not as expected of a factor for increasing SHBG, being overweight with a low lipid profile can negatively impact. Inflammation While some level of inflammation is necessary for general health in the fight against disease or injury, what we might call chronic inflammation can lead to increases in SHBG and corresponding lower levels of free testosterone   Get Your Levels Checked: SHBG Test, Free & Total Testosterone Test   Testing your SHBG levels along with both total and free testosterone is particularly important if one wants to get to the bottom of hypogonadism (low testosterone) symptoms they may be experiencing. Remember, a total testosterone test alone, which some physicians will run, is not enough. For most adult men, SHBG levels will run between 10 nmol/L and 60 nmol/L if in the optimal range. If SHBG levels are greater than 60 nmol/L and your free testosterone is less than 2% of your total testosterone, there is a good chance your SHBG levels are too high.   Discounted Labs sells several lab test panels that measure SHBG levels that you can buy without a doctor's visit:   Testosterone (Total and Free), SHBG, CBC - Hematocrit, Ultrasensitive Estradiol and PSA   Testosterone, Free, Bioavailable and Total (Upper Limit T 1,500 ng/dL) plus SHBG   CBC, CMP, TT, FT, Lipids, Prolactin, Ultra-Sensitive Estradiol, and SHBG   Testosterone, Free, Bioavailable, and Total, LC/MS (No Upper Limit) plus SHBG   As we now understand SHBG, our next question is what can be done to lower it, increasing free testosterone in the body? There is nothing we can do about aging. As each day passes, we grow older, but there are still things we can do that will improve this factor.   How to Lower SHBG Levels:   The most obvious answer to the problem of low free testosterone and high levels of SHBG is to increase testosterone. Exercise more, consume a cleaner diet, and lose weight; all of these things will increase your testosterone levels. Your levels may not increase massively, but some increase means a higher total to pull from and a greater amount of free testosterone based on the 2% fraction. If this isn't enough - perhaps you're not reaching a 2% fraction due to elevated SHBG – one may need to consider talking to their doctor about testosterone supplementation. However, even if supplementing with exogenous testosterone, the habits mentioned are good for overall health and can only have a positive impact.   Another possible solution, and one of the more commonly needed, is lowering estradiol levels in the body. We tend to think estrogen hormones are needed for females only, but they are also crucial for men, granted in smaller amounts. As it pertains to estrogen, too much estradiol can lead to elevated levels of SHBG. If testosterone levels are also low, this can lead to even more negative factors. But it's important not to get carried away as estradiol that's too low will bring with it numerous symptoms; in fact, your life could be miserable in that regard.   Many men who are at least somewhat familiar with testosterone have been wrongly been told that too much testosterone can lead to gynecomastia due to elevated levels of estrogen in the body due to the aromatization of testosterone to estrogen. But low levels of testosterone in the body with present high levels of SHBG and estradiol can have the effect of causing gynecomastia. In order to combat high levels of estradiol, avoiding certain foods, especially those that are soy-based, will be important. Equally important is living a healthy lifestyle and incorporating what was mentioned above: adequate exercise, a healthy diet, and getting enough sleep. These things will help lower estradiol. Some men will also need medical help through medications known as aromatase inhibitors if they have gynecomastia, although most men on TRT do not need an AI. Too many men have relied on aromatase inhibitors out of fear for too many years. In reality, most men who supplement with exogenous testosterone can, in fact, control estrogen via non-medicated factors.   Some studies have shown that supplementation with DHEA (Dehydroepiandrosterone) may also lower SHBG. However, more study is needed to understand this properly, as too much DHEA can prove problematic. High doses of DHEA supplements have been associated with increased estradiol, so you must speak to your doctor first before beginning such a supplementation regimen.   Very Low SHBG :   We are then left with one factor we've yet to discuss much because it isn't all that common: low SHBG, or rather, levels of SHBG that are too low. Levels of SHBG that are too low may be an indicator of other underlying health issues. This may be an indicator of a metabolic problem. Low levels of SHBG are a standard indicator of those with diabetes. It doesn't appear, as data suggests, that insulin resistance is caused by low SHBG, but it may be a useful marker. More data is currently needed on this topic.   An A1c test will be needed to know with certainty in terms of your diabetic health.   While low SHBG is not a common concern for most men, new data has produced interesting results and information. A recent study published in the Journal of Clinical Endocrinology and Metabolism provides such information.   The process showed a man with undetectable levels of SHBG and low levels of testosterone accompanied by nearly a decade of hypogonadism symptoms. They discovered a family with a missense mutation in the SHBG gene from studying this individual. Interestingly enough, they found this issue did not interfere with the individual's spermatogenesis or general gonadal development. This leads the study to conclude SHBG may not play a significant role in the maturation of the male species physiologically or sexually.   More interesting than the JCEM study is things that new data suggest may negatively impact all men. Low levels of SHBG have recently been associated with three medical conditions that are known to be the silent killers of many men: heart disease, metabolic syndrome, and diabetes. Again, currently, it is being viewed as a marker and not as direct causation, but this new information is important as it acknowledges that more studies must be done.   Low SHBG has also been associated with:   Obesity Obesity is a factor we all well understand and is an issue that leads to problems in many health areas, and often in numerous possible directions. Cushing Disease It is associated with extended exposure to high levels of cortisol. Hypothyroidism It is associated with an under-active thyroid. Excessive levels of growth hormone Exceedingly rare for most, although possible via genetic factors or abuse of exogenous forms. Abuse through anabolic steroids     Is SHBG an Enemy of Hormone? - Emerging Studies   As we mentioned, androgens like testosterone and DHEA and estrogens are transported to the sex hormone binding globulin (SHBG). SHBG is believed to keep sex hormones inactive and to control the amount of free hormones that enter cells by passive diffusion. Contrary to the free hormone hypothesis, some researchers have demonstrated that megalin, a receptor in ovaries and testicles, acts as a pathway for cellular uptake of biologically active androgens and estrogens bound to SHBG. We will see more data on this newly found receptor that actually enables the body to use hormones bound to SHBG in the near future.   In endocrinology, the body has no “harmful” or “good” hormone. Their balance and harmony with each other matters for the best health.     References:   Ding et al. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. The New England Journal of Medicine. Aug 2009. Vos et al. Sex Hormone Binding Globulin Deficiency Due to a Homozygous Missense Mutation. Journal of Clinical Endocrinology and Metabolism. Sept 2014 SHBG and Free Testosterone - Everything You Need to Know Hammes et al. Role of Endocytosis in Cellular Uptake of Sex Steroids. Cell. Sept 2005  

  Pondering about the perfect Father's Day gift? Are you contemplating a case of his favorite craft beer, premium Omaha steaks, or maybe a surprise getaway to his favorite city? All these are excellent choices to show appreciation to your father on this special day. But what if there's a more impactful gift - the gift of health? As men age, their health often becomes a challenge. Conditions ranging from fatigue, muscle loss, joint pains to reduced flexibility are commonplace. Some issues, like unexplained tiredness, low mood, frequent illnesses, and doctor visits, might be less conspicuous yet more concerning. Does this ring a bell? Father's Day Lab Test Sale Fret not! Here's an innovative solution. This Father's Day, consider gifting your father a lab test from DiscountedLabs.com. It's a proactive step towards ensuring his optimum health, with no doctor's visit required! Use this discount code FATHERSDAY20 to save 20% on your lab test order, valid until June 30, 2023. Beneficial Lab Tests for Older Men: Consider these potentially life-enhancing tests for your dad: Annual Physical Panel - A comprehensive health check including CBC, CMP panels, A1C, TSH (thyroid function), urinalysis, and lipid profile. Total and Free Testosterone Test - A measure of your father's testosterone levels to ensure he maintains a healthy hormonal balance for his age. Thyroid Panel - A comprehensive assessment of his free T3 and free T4 thyroid hormones, providing insights into potential thyroid-related health issues. A medical checkup as a gift may sound unconventional, right? Yet, once you peruse these studies, you'll understand why such tests are invaluable for your father's health and well-being. The Power of Testosterone in Older Men: Recent studies underscore the immense benefits of healthy testosterone levels in men, even beyond their prime years. Three independent studies discovered that men with optimal testosterone levels enjoyed better health. For men over 65, testosterone treatment helped achieve hormone levels typical for a 19- to 40-year-old, yielding noticeable improvements: 8% enhanced performance in a 6-minute walking test. Reported better moods and significantly lower rates of depression. Improved mood and increased energy production, although no reduction in the risk of cardiac events and prostate conditions was noted. Reduced Hospitalization Rates with Testosterone: A May 2016 Mayo Clinic study discovered that men undergoing testosterone therapy were less likely to be rehospitalized within 30 days of hospital discharge. The therapy especially benefited men with low testosterone levels, reducing their chances of readmission due to testosterone deficiency-related health issues. Combatting Depression with Testosterone: Research indicates a correlation between lower levels of circulating testosterone and depression in men. A study following over 3,100 older men for a decade found that those who developed depression had significantly lower total testosterone levels. This revelation implies that checking and adjusting testosterone levels can help manage depression commonly found in older men. Give the Gift of Health: This Father's Day, empower your father with the gift of knowledge about his health. Through these tests, he'll gain insights into his body's inner workings. He'll learn about his thyroid and testosterone levels and their potential impact on his well-being. Perhaps, testosterone therapy could be his key to a happier, healthier life. This Father's Day, give your father a gift that will keep giving for years to come. Take a proactive step towards his health today, contributing to a longer, healthier life. Remember to use the DiscountedLabs.com coupon code: FATHERSDAY20 and give your father the gift of a healthier tomorrow! Where Does Discounted Labs Operate?  If you live in one of the following states, you can take advantage of our discounted blood work: Alabama, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nebraska, Nevada, North Carolina, New Mexico, Ohio, Oklahoma, Oregon, Pennsylvania, South Carolina, Tennessee, Texas, Utah, Virginia, Washington, and West Virginia. We do not serve NY, NJ, RI, and AZ. How Does Discounted Labs Work? 1-     Click on the Lab Near You page to ensure we serve your state and that a location is near you.  2-     If a location is near you, go to "Choose a Test" and add your selection (s) to the shopping cart. You can also save money by buying bundled lab test panels. 3-     If you have a discount coupon code, add it to your cart. You will earn points for every purchase you can redeem in future orders. 4-     If you don't have an account with us, you will be asked to create one by adding your name, address, gender, and date of birth. Note: You cannot place an order for someone else unless you create an account for them. 5-     Place your order by using a credit card. 6-     You will receive three emails: an order confirmation & detailed instructions within minutes about how to download your lab requisition form to take to the lab near you. 7-     Print the lab requisition form (PDF file).  8-     Take that form to the  lab near you . You can walk in, but we suggest you make an appointment to cut down on potential waiting (instructions on how to do so are on our "Find a Location" page). Get your blood drawn at the lab.   9-    Your results will be ready within 2-7 business days (Depending on the test. Sensitive hormone tests done by liquid chromatography/mass spectrometry LC/MS take 5-7 business days). You will receive them by email as soon as they come in. Please contact us if you have any questions. We also have answered a lot of questions in our Frequently Asked Questions page IF YOU WOULD RATHER WATCH A VIDEO DESCRIBING HOW WE WORK: HOW TO ORDER DISCOUNTED LABS ONLINE Why DiscountedLabs.com? We Have the Most Affordable Lab Tests Available in the U.S. No Doctor Visit is Required. Our In-House Doctor Provides a Prescription at No Extra Cost to You. Private and Confidential Lab Test Results. We Serve Most U.S. States. In Operation for Over 8 Years. Orders are Valid for 6 Months. Simple Menu and Process.  Order 24/7 You Get a Lab Requisition Form A Few Minutes After Your Order. No, Wait. No Hidden Costs. An $8 Lab Draw Fee is Added to Your Order. Our Blood Tests are FDA Approved. We are HIPAA Compliant. We Protect Your Privacy. Your Order is Good for 180 Days. You Do Not Have to Rush to the Lab. Over 1,900 Lab Locations Around the United States. No Appointment is Needed. Walk-ins Welcomed. Your Blood Test Results are Delivered by Private Email. We Provide Hormone Testing Via Sensitive LC/MS Assays. We avoid less accurate testing. We Have Created Blood Test Panels Applied to Different Needs. Discount Coupons Emailed Periodically. Educational Videos and Articles are Provided on Our Blog Page We Educate Consumers on How to Interpret Lab Test Results with Their Physicians. We Provide Resources for Clinical Care and Consumer Forums on Our Resources Page   Here is a VIDEO DESCRIBING HOW WE WORK: HOW TO ORDER DISCOUNTED LABS ONLINE  

Estradiol in Men: What is the Most Accurate Blood Test? Table of Contents Estradiol in Men: What is the Most Accurate Blood Test? Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men Objective: Design and Setting: Main Outcome Measures: Results: Conclusions: BUY SENSITIVE ESTRADIOL TEST HERE  Recent studies show the importance of estradiol in men and how low estradiol can be detrimental for not only for bone but also for sex drive. Low estradiol has also been linked to fat gain. So, physicians should be careful about treating men who are obviously being over diagnosed with high estradiol due to the use of the wrong test. This study compares the old estradiol blood test assay (ECLIA) to the more accurate sensitive one (LC/MS/MS). The sensitive estradiol test is a method for measuring estradiol levels in men (and children) using a sensitive liquid chromatography-tandem mass spectrometry (LC/MS)-based assay[2]. It is considered more accurate for men because it provides better sensitivity and accuracy at lower estradiol concentrations, which are typically found in men, as opposed to higher concentrations found in adult females[1][2]. Immunoassay-based estradiol tests, on the other hand, perform best at higher concentrations of estradiol, making them more suitable for individuals with levels in the adult-female range[2]. The sensitive estradiol test, with its greater sensitivity at lower levels, is more appropriate for men who generally have lower levels of estradiol compared to adult females[3]. Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men  (Source: The Journal of Clinical Endocrinology & Metabolism, Volume 98, Issue 6, 1 June 2013, Pages E1097–E110)   Immunoassay-based techniques, routinely used to measure serum estradiol (E2), are known to have reduced specificity, especially at lower concentrations, when compared with the gold standard technique of mass spectrometry (MS). Different measurement techniques may be responsible for the conflicting results of associations between serum E2 and clinical phenotypes in men. Objective: Our objective was to compare immunoassay and MS measurements of E2 levels in men and evaluate associations with clinical phenotypes. Design and Setting: Middle-aged and older male subjects participating in the population-based Osteoporotic Fractures in Men (MrOS) Sweden study (n = 2599), MrOS US (n = 688), and the European Male Aging Study (n = 2908) were included. Main Outcome Measures: Immunoassay and MS measurements of serum E2 were compared and related to bone mineral density (BMD; measured by dual energy x-ray absorptiometry) and ankle-brachial index. Results: Within each cohort, serum E2 levels obtained by immunoassay and MS correlated moderately (Spearman rank correlation coefficient rS 0.53–0.76). Serum C-reactive protein (CRP) levels associated significantly (albeit to a low extent, rS = 0.29) with immunoassay E2 but not with MS E2 levels. Similar associations of immunoassay E2 and MS E2 were seen with lumbar spine and total hip BMD, independent of serum CRP. However, immunoassay E2, but not MS E2, associated inversely with ankle-brachial index, and this correlation was lost after adjustment for CRP (C Reactive Protein- An Inflammatory marker). Conclusions: Our findings suggest interference in the immunoassay E2 analyses, possibly by CRP or a CRP-associated factor. Although associations with BMD remain unaffected, this might imply for a reevaluation of previous association studies between immunoassay E2 levels and inflammation-related outcomes. BUY SENSITIVE ESTRADIOL TEST HERE   

A liver function test is an essential diagnostic tool that helps assess the health of your liver and identify potential issues early on. The liver plays a crucial role in maintaining overall well-being, as it processes nutrients from food, filters toxins, produces proteins for blood clotting, and much more. This article will explore the significance of understanding liver function tests and how they can be utilized to track one's health. Throughout this post, we'll discuss the key components of a comprehensive liver panel test, including enzymes and proteins examined such as total protein, albumin, globulin, and bilirubin levels, among others. We'll also highlight when you should get tested for optimal results. In addition to discussing regular testing schedules based on individual needs or risk factors associated with chronic liver disease like non-alcoholic fatty liver disease or alcohol-related conditions. Furthermore, we will explore additional tests that may be recommended based on initial results, such as hepatitis virus testing or even a liver biopsy. Finally, this article will provide information about convenient and affordable testing options available today through online ordering platforms, allowing individuals to receive their results quickly and without hassle. Table of Contents: Understanding Liver Function Tests Importance of Liver Health in Overall Well-being Key Components of a Comprehensive Liver Panel Test Enzymes and Proteins Examined in a Liver Panel Test Total Protein Albumin Globulin Gamma Glutamyl Transpeptidase (GGT) The Significance of Early Detection through Testing When Should You Get Tested? How Often Should You Test? Additional Tests Based on Initial Results Hepatitis Virus Testing Liver Biopsy Convenient and Affordable Testing Options Online Ordering of Liver Function Tests Receiving Results Quickly FAQs in Relation to Liver Function Test What is a liver function test? How often should I get a liver function test? What do the results of a liver function test indicate? Are there any risks associated with getting a liver function test? Conclusion Understanding Liver Function Tests Liver function tests are essential diagnostic tools that help determine the health of your liver by examining various enzymes and proteins. These tests can detect potential issues early on, allowing for timely intervention and treatment to prevent further damage to this vital organ. Importance of Liver Health in Overall Well-being The liver plays a crucial role in maintaining overall health as it is responsible for more than 500 bodily functions, including filtering out toxins from the foods you eat and liquids you drink. A healthy liver contributes significantly to our well-being; therefore, it's important to monitor its condition regularly through liver function tests. Key Components of a Comprehensive Liver Panel Test A comprehensive liver lab test panel looks at several variables and enzymes that provide valuable information about the current state of your liver's health. Some key components include: Total Protein: Essential for tissue health and regeneration. Albumin: An important protein that indicates heart or kidney problems. Globulin: Produced by the liver and immune system, helps fight bacteria and viruses. Bilirubin Levels: Indicates bile flow obstruction or jaundice development due to excessive toxins or drugs present in the bloodstream. Alkaline Phosphatase (ALP): Helps identify bone problems or potential liver issues. Lactate Dehydrogenase (LDH): Primarily found in heart muscle, high levels may indicate heart problems. In addition to these key components, other enzymes such as aspartate aminotransferase (AST), alanine transaminases (ALT), and gamma glutamyl transpeptidase (GGT) are also examined to determine liver health. High levels of these enzymes may indicate liver problems caused by excessive alcohol consumption, toxins, or drugs. Regular monitoring with liver function tests is crucial for maintaining overall health since some symptoms may not appear until it's too late. Early detection allows doctors to recommend therapies or lifestyle changes that can help mitigate issues while giving the liver an opportunity to regenerate itself. When should you get tested? It's always better to do a hepatic function panel sooner rather than later. Although some liver issues may not cause any symptoms, it is still advisable to get tested regularly. It's recommended to do a liver test panel periodically when taking certain medications that might affect your liver, as well as if you see apparent symptoms of liver problems such as yellowing of the eyes. Understanding liver function tests is essential to maintaining overall health and wellness. Enzymes and proteins examined in a liver panel test provide an even more detailed look into the functionality of this vital organ.   Key Takeaway:  Liver function tests are important diagnostic tools that can detect potential liver issues early on. Regular monitoring with these tests is crucial for maintaining overall health, as the liver plays a vital role in filtering out toxins and contributing to our well-being.  Enzymes and Proteins Examined in a Liver Panel Test A comprehensive liver lab test panel looks at several variables and enzymes, each providing valuable information about the current state of your liver's health. Let's discuss some of these key components: Total Protein This test measures the total amount of protein in your body, which is essential for tissue health and regeneration. Abnormal protein levels may indicate malnutrition or muscle wasting. Albumin As one of the most important proteins in the human body, albumin levels can reveal potential issues with your heart or kidneys. Testing for albumin is crucial to determining liver health. Globulin The liver and immune system both produce this protein, which aids in battling viruses and bacteria. Low globulin levels may signify poor liver function or a weakened immune system. Bilirubin Levels Total Bilirubin: This cellular antioxidant is secreted as a result of red blood cell breakdown. High bilirubin levels can cause jaundice (yellowing of the eyes or skin) due to obstructed bile flow or an overwhelmed liver. Direct Bilirubin: Also known as conjugated bilirubin, this type specifically indicates whether there's an issue with bile secretion from the liver into the intestines. Indirect Bilirubin: An elevated level suggests that there might be excessive red blood cell destruction happening within your body. Liver Enzymes: Alkaline Phosphatase, Lactate Dehydrogenase, Aspartate Aminotransferase and Alanine Transaminases Alkaline Phosphatase (ALP): High ALP levels may indicate bone problems or liver damage. Lactate Dehydrogenase (LDH): Found in heart muscle tissue, abnormal LDH levels can signal potential heart issues. Aspartate Aminotransferase (AST): Low levels are normal; however, high AST levels suggest muscle damage or liver problems due to excessive alcohol consumption. In such cases, patients should stop drinking and retest after a few weeks. Alanine Transaminases (ALT): This enzyme is commonly found in the liver. Elevated ALT is a sign of potential liver damage from toxins, drugs, or alcohol. Important note: Resistance exercise can increase liver enzymes. A study performed in Sweden and published in the February 2008 issue of the British Journal of Pharmacology was designed to investigate the effect of intensive muscular exercise (weightlifting) on a single occasion on liver enzymes in healthy men not used to performing weightlifting on a regular basis. A secondary objective was to investigate the effect of a single occasion of intensive muscular exercise (weightlifting) on clinical chemistry parameters reflecting muscle damage, i.e., creatine kinase (CK) and myoglobin. Fifteen healthy men, used to moderate physical activity, not including weightlifting, performed a 1-hour-long weight training program. Five out of eight studied clinical chemistry parameters (AST, ALT, LD, CK, and myoglobin) increased significantly after exercise and remained elevated for at least 7 days postexercise. Bilirubin, GGT, and ALP remained within the normal range. The liver function parameters, AST and ALT, were significantly increased for at least 7 days after the exercise. In addition, LD and, in particular, CK and myoglobin showed highly elevated levels. These findings highlight the importance of imposing restrictions on weightlifting prior to and during clinical studies to avoid making wrong assumptions about liver toxicity caused by study medications. Intensive muscular exercise, e.g., weightlifting, should also be considered a cause of asymptomatic elevations of liver function tests in daily clinical practice. This is why GGT may be more accurate for men who actively do weight training. Gamma Glutamyl Transpeptidase (GGT) An increase in GGT might signify serious liver issues like cirrhosis or hepatitis. Regular monitoring of this enzyme through a liver panel test is essential for early detection and treatment of any underlying conditions affecting your liver's health. A liver panel test can be a useful indicator of shifts in the amounts of enzymes and proteins within your body, enabling you to take steps if necessary. To ensure optimal health, it's important to be aware of the recommended frequency for liver panel tests The Significance of Early Detection Through Testing Regular monitoring with liver function tests is crucial for maintaining overall health since some symptoms may not appear until it's too late. Early detection allows doctors to recommend therapies or lifestyle changes that can help mitigate issues while giving the liver an opportunity to regenerate itself. In this section, we will discuss when and how often you should get tested. When Should You Get Tested? It's always better to do a liver function test sooner rather than later. Certain liver issues may not cause any indications, so you could be oblivious to their presence. It's recommended to do a liver test panel periodically when taking certain medications that might affect your liver, as well as if you see apparent symptoms of liver problems such as yellowing of the eyes. How Often Should You Test? Routine Check-ups: If you don't have any known risk factors or pre-existing conditions related to your liver, getting tested every one or two years during routine check-ups is generally sufficient. Risk Factors: For those with risk factors such as obesity, diabetes, high blood pressure, a family history of liver disease, or excessive alcohol consumption; more frequent testing (every six months) is advisable. Taking Medications: If you're taking long-term medication that has potential side effects on the liver, regular monitoring (every three months) would be prudent in order to catch any adverse reactions early on. Besides these general guidelines, it's essential to consult with your healthcare provider regarding personalized testing recommendations based on your unique health profile and circumstances. Remember, early detection is key to preventing liver damage and ensuring optimal liver function. Once you have been tested and received the results, your doctor will help you interpret them. In some cases, and only if necessary, you might need to do additional tests, such as a hepatitis virus test. A biopsy might also be required to confirm a specific diagnosis before beginning treatment. Early detection through testing is a critical factor in safeguarding your health, since it allows for the identification of any potential issues prior to them becoming more serious. With this knowledge, we can now look at additional tests based on the initial results to further assess the condition of your liver.   Key Takeaway:  Regular liver function tests are crucial for maintaining overall health and detecting asymptomatic liver problems early on. The frequency of testing depends on risk factors such as obesity, diabetes, high blood pressure, a family history of liver disease, or excessive alcohol consumption. It's important to consult with a healthcare provider for personalized testing recommendations based on individual circumstances. Additional Tests Based on Initial Results After receiving the results of your comprehensive liver panel test, it is crucial to consult with a healthcare professional for proper interpretation and guidance. In some cases, elevated levels of certain enzymes may warrant further examination through additional tests. These supplementary assessments can provide more specific diagnoses and help determine the most appropriate course of treatment for liver-related issues. Hepatitis Virus Testing If abnormal enzyme levels are detected during the initial liver panel test, hepatitis virus testing might be recommended by your doctor. Viral infections like hepatitis A, B, or C cause hepatitis, which is an inflammation of the liver. Left untreated, hepatitis virus infections can result in chronic liver disease and potentially life-threatening complications. Hepatitis A: Typically transmitted through contaminated food or water sources, vaccination is available for prevention. Hepatitis B: Transmitted via blood or bodily fluids; vaccination available for prevention. Hepatitis C: Primarily spread through contact with infected blood; no vaccine is currently available, but curative treatments exist. Liver Biopsy In instances where further clarification is needed after initial test results and hepatitis virus testing have been conducted, a doctor may recommend undergoing a liver biopsy. This procedure involves removing a small sample of liver tissue using a needle, which will then be examined under a microscope to identify any abnormalities that could indicate conditions such as: Fatty liver disease: A buildup of fat in the liver cells, which can lead to inflammation and scarring. Cirrhosis: Severe scarring of the liver that impairs its ability to function properly. Hepatitis or other infections: Inflammation caused by viral, bacterial, or parasitic infections that damage the liver. Liver cancer: Malignant tumors originating from the liver tissue itself or spreading from another part of the body (metastatic). Taking a proactive approach to your health through regular monitoring with liver panel tests is essential for early detection and intervention. By identifying potential issues before they become severe, you give yourself an opportunity to make lifestyle changes and seek appropriate treatments under professional guidance. Remember that knowledge is power when it comes to maintaining optimal health. Subsequent assessments based on preliminary findings can furnish a more precise understanding of your liver condition, enabling an exacter prognosis. To make testing even easier, Discounted Labs offers convenient and affordable options for ordering lab tests online.   Key Takeaway:  After receiving the results of a liver panel test, it's important to consult with a healthcare professional for proper interpretation and guidance. Abnormal enzyme levels may warrant further examination through additional tests such as hepatitis virus testing or liver biopsy to identify potential issues before they become severe. Convenient and Affordable Testing Options With the increasing importance of liver health, it's essential to have access to convenient and affordable testing options. Thankfully, modern technology has made it possible for individuals to order blood test panels online through websites like DiscountedLabs.com. This innovative service offers a wide range of tests at competitive prices, making it easier than ever before for people to monitor their liver function regularly. Online Ordering of Liver Function Tests The process of ordering a comprehensive hepatic function panel is quite simple. All you need to do is visit DiscountedLabs.com and select the appropriate test from their extensive list. Once you've placed your order, they will send you a form via email that contains all the necessary information required by your local lab. No doctor's visit: One significant advantage of using this service is that there's no need for a doctor's appointment or referral. You can directly order the tests yourself without any hassle. User-friendly interface: The website features an easy-to-navigate design with clear instructions on how to proceed with each step in the ordering process. Coverage across most cities in the U.S.: With numerous partner labs located throughout most cities in the United States, finding one near you should be relatively straightforward. Receiving Results Quickly A key benefit of utilizing online services like DiscountedLabs.com lies in their ability to deliver results quickly and efficiently. Once the blood sample has been taken, DiscountedLabs.com typically returns results within a few business days, allowing you to quickly take any necessary action to maintain your liver's health. This rapid turnaround time allows you to take prompt action if any issues are detected, ensuring that your liver remains in optimal condition. Confidentiality: Rest assured that your personal information and test results will be kept strictly confidential, as DiscountedLabs.com adheres to strict privacy policies. Ease of interpretation: The results provided by the lab are easy to understand, with clear explanations for each enzyme or protein level measured. Should the need arise, a healthcare expert can always be consulted to further elucidate the results.  By taking advantage of online services like DiscountedLabs.com, you can ensure that your liver function is regularly monitored without breaking the bank or sacrificing convenience. So why wait? Order a comprehensive liver panel test today and take control of your health.   Key Takeaway:  DiscountedLabs.com offers a convenient and affordable way to monitor liver function through the online ordering of comprehensive liver panel tests without the need for a doctor's visit. With quick results, easy interpretation, confidentiality, and coverage across most cities in the U.S., individuals can take control of their health by regularly monitoring their liver function. FAQs in Relation to Liver Function Test What is a liver function test? These tests help detect liver diseases or damage early on, allowing for timely treatment and management of any underlying conditions. How often should I get a liver function test? The frequency of getting a liver function test depends on your individual risk factors, such as family history of liver disease, alcohol consumption habits, or the presence of other medical conditions. Generally speaking, it's recommended to have these tests done annually if you're at higher risk or every 2–5 years if you're at lower risk. What do the results of a liver function test indicate? Results from a liver function test can provide insight into how well your liver is working. Abnormal levels may indicate inflammation, infection (e.g., hepatitis), cirrhosis (scarring), fatty infiltration (steatosis), or even cancer in some cases. It's important to discuss your results with your healthcare provider for proper interpretation and guidance. Are there any risks associated with getting a liver function test? Liver function tests are generally safe, with minimal risks involved since they only require drawing blood samples through venipuncture. Some potential side effects include pain during needle insertion or mild bruising around the puncture site; however, serious complications are rare. How can I prepare for my liver function test at Discounted Labs? To prepare for your liver function test, follow any instructions provided by the testing facility. In general, you should avoid eating or drinking anything other than water for 8–12 hours before the test and inform your healthcare provider of any medications or supplements you're taking, as they may affect the results. Conclusion Understanding liver function tests is crucial for maintaining overall health and wellness.  Early detection through testing is key to preventing serious liver conditions. Additional tests, such as hepatitis virus testing or a liver biopsy, may be necessary based on the initial results. Convenient and affordable online ordering of liver function tests allows individuals to receive their results quickly. If you're interested in monitoring your own health with a discounted panel that includes a liver function test, visit DiscountedLabs.com.   

When it comes to labs for fatigue, understanding the multifactorial causes of chronic fatigue is essential in order to provide an accurate diagnosis and an effective treatment plan. Fatigue symptoms can be a result of various medical conditions, such as anemia, thyroid dysfunction, hormonal imbalances, or even inflammation. In this blog post, we will delve into different tests that are crucial in identifying the root cause of your persistent tiredness. We'll explore labs for fatigue, focusing on blood tests like complete blood count (CBC), iron level testing, and vitamin B12 and folate deficiencies, which are vital in diagnosing anemia-related issues. Furthermore, we will discuss thyroid function tests for diagnosing hypothyroidism and their role in addressing fatigue management. The importance of hormone regulation, including testosterone levels and adrenal function, will also be highlighted, along with glucose regulation assessments. Last but not least, we will touch upon the significance of identifying inflammation as a contributing factor to ongoing exhaustion. By gaining insight into these comprehensive lab evaluations, you can better understand your body's needs and work towards improved health and energy levels. Table of Contents: Understanding Fatigue and Its Multifactorial Causes The Importance of Identifying Hormonal Imbalances Benefits of Using a Comprehensive Lab Testing Approach Anemia as a Contributor to Fatigue How Vitamins B12 and Folate Play a Role in Red Blood Cell Production Identifying Deficiencies through CBC Testing Assessing Thyroid Function for Optimal Energy Levels Vitamin D Deficiency Impact on Energy Levels Sources of Vitamin D Exposure Recommended Daily Intake Guidelines Testosterone's Role in Energy and Fatigue Symptoms of Low Testosterone Treatment Options to Restore Hormonal Balance Evaluating Adrenal Function for Optimal Stress Response How Cortisol Affects Overall Health The Importance of Balanced Adrenal Hormones Inflammation, Epstein Barr Virus, and Their Connection to Fatigue Identifying Sources of Inflammation through CRP Testing Symptoms Associated with Mononucleosis Caused by Epstein Barr Virus FAQs in Relation to Labs for Fatigue What labs should be checked for fatigue? What does a fatigue blood test show? Conclusion Understanding Fatigue and Its Multifactorial Causes Fatigue is a common complaint that can result from imbalances in several hormones. It's essential to get an affordable fatigue panel on DiscountedLabs.com, which includes most hormones and variables involved in diagnosing and treating fatigue for both men and women. Ordering this comprehensive panel provides substantial cost savings compared to ordering each test separately. The Importance of Identifying Hormonal Imbalances Hormonal imbalances can be disruptive to the body's normal functioning, causing issues such as fatigue and thyroid or adrenal disorders. When hormones are not in balance, it can result in prolonged exhaustion or other medical issues such as thyroid problems or adrenal malfunction. By identifying these imbalances through blood tests like the ones offered by Discounted Labs, you can take steps towards finding effective treatment options tailored specifically for your needs. Benefits of Using a Comprehensive Lab Testing Approach Better accuracy: A comprehensive lab testing approach allows healthcare providers to identify the root cause(s) of your fatigue symptoms more accurately than relying solely on individual tests. Affordability: Bundling multiple tests into one package helps save money compared to ordering them individually. Simplicity: The process becomes easier with all necessary tests available under one roof, making it convenient for those seeking answers about their persistent tiredness without having the access (or funds) needed to visit multiple specialists or doctors' offices throughout town. Chronic fatigue is a debilitating condition that affects millions of people worldwide. A full night's sleep does not alleviate the severe fatigue that characterizes chronic fatigue syndrome (CFS), a medical condition that lasts for more than six months. It's crucial to make an accurate diagnosis of CFS, which DiscountedLabs.com can do with blood tests. Vitamin B12 deficiency is a common cause of fatigue symptoms. It's essential to get tested for low vitamin B12 levels, which can lead to anemia, nerve damage, and other health issues. DiscountedLabs.com offers a vitamin B12 test that can help identify if you have a deficiency. Iron deficiency is another common cause of fatigue symptoms. Iron is essential for healthy blood cells, and a lack of it can lead to anemia. DiscountedLabs.com offers an iron panel that can help identify if you have an iron deficiency. Thyroid hormones play a crucial role in regulating our metabolism and energy levels. An underactive thyroid gland can lead to fatigue, weight gain, and other health issues. DiscountedLabs.com offers a thyroid panel that can help identify if you have an underactive thyroid. Liver disease can also cause fatigue symptoms. The liver is responsible for filtering toxins from our bodies and producing essential proteins. When the liver is not functioning correctly, it can lead to fatigue and other health issues. DiscountedLabs.com offers a liver panel that can help identify if you have liver disease. Overall, getting a comprehensive fatigue panel from DiscountedLabs.com can help identify the root cause(s) of your fatigue symptoms and provide you with the necessary information to find effective treatment options. Don't let fatigue hold you back from living your best life. Fatigue can have multiple causes, and it is essential to determine any possible hormonal discrepancies in order to address the problem effectively. Anemia may also contribute to fatigue, so next we will look at how vitamins B12 and folate play a role in red blood cell production. "Take control of your fatigue symptoms with DiscountedLabs.com. Get a comprehensive panel to identify hormonal imbalances and find effective treatment options. #FatigueTesting #AffordableHealthcare" Click to Tweet Anemia as a Contributor to Fatigue Anemia, which results from insufficient red blood cells or hemoglobin production, may contribute to feelings of exhaustion. Low iron levels can stem from chronic blood loss; therefore, tests like a complete blood count (CBC) and iron level testing, including total iron binding capacity (TIBC), are crucial for identifying this issue. How Vitamins B12 and Folate Play a Role in Red Blood Cell Production A vitamin B12 and folate deficiency can impair the body's capacity to generate healthy red blood cells, leading to anemia. Poor dietary intake or malabsorption problems are common causes of vitamin B12 deficiency, whereas an unbalanced diet is typically the root cause of inadequate folic acid intake. Both vitamin deficiencies should be addressed through proper nutrition and supplementation, if necessary. Identifying Deficiencies through CBC Testing Hemoglobin: Measures the amount of oxygen-carrying protein in your red blood cells. Hematocrit: Evaluates the percentage of your total blood volume that consists of red blood cells. Red Blood Cell Count (RBC): Determines the number of circulating red blood cells in your bloodstream. MCH/MCV/MCHC: These indices provide information about the size and shape of your red blood cells, which can help identify specific types of anemia such as iron deficiency or vitamin B12/folate deficiency-related anemias. In addition to the CBC test, iron and TIBC tests can help determine the cause of anemia by assessing your body's iron stores and ability to transport iron in the blood. By being aware of these factors, you can collaborate with a healthcare professional to create a specific treatment strategy for anemia-related fatigue. Anemia is a common contributor to fatigue and can be identified through CBC testing. Assessing thyroid function for optimal energy levels is another important step in addressing this issue. "Take charge of your fatigue with discounted lab tests from Discounted Labs. Identify anemia and vitamin deficiencies through CBC testing. #healthyliving #labtests #fatigue" Click to Tweet Assessing Thyroid Function for Optimal Energy Levels Hypothyroidism occurs when the thyroid gland does not produce enough thyroid hormones, which often leads to symptoms such as lethargy or weight gain. To maintain optimal energy levels, it's crucial to assess your thyroid function regularly. Common Symptoms Associated with Hypothyroidism Fatigue and weakness Weight gain or difficulty losing weight Dry skin and hair loss Sensitivity to cold temperatures Muscle aches and joint pain Depression and mood swings Importance of Regular Monitoring for Optimal Treatment To accurately diagnose hypothyroidism, healthcare providers use blood tests that measure various thyroid hormones. These include TSH (thyroid-stimulating hormone), free T3 & free T4 along with thyroid antibody testing. By monitoring these levels regularly, you can ensure proper treatment adjustments are made in response to any fluctuations in your thyroid health. If you suspect an issue with your thyroid function, consider ordering an affordable fatigue panel from DiscountedLabs.com. This comprehensive test includes all essential markers needed for diagnosing potential hormonal imbalances related to chronic fatigue or other medical conditions affecting energy levels. With an accurate diagnosis come effective treatment plans tailored to your specific needs, ultimately leading to improved overall well-being and vitality. Consistent assessment of thyroid performance is vital for sustaining optimal vigor and can be easily achieved with a straightforward lab examination. It is essential to contemplate vitamin D insufficiency for a better comprehension of its influence on exhaustion. "Take control of your energy levels by assessing your thyroid function regularly. Order a comprehensive fatigue panel from Discounted Labs for accurate diagnosis and effective treatment plans. #thyroidhealth #fatiguepanel #DiscountedLabs" Click to Tweet Vitamin D Deficiency Impact on Energy Levels Vitamin D deficiency is another prevalent nutrient deficiency that contributes significantly to low energy levels, making vitamin D testing necessary too. Ensuring adequate vitamin D intake helps maintain overall well-being by supporting bone health, immune function, and mood regulation, among other vital functions within the body. Sources of Vitamin D Exposure Your body can produce vitamin D through exposure to sunlight or obtain it from dietary sources and supplements. Foods such as fatty fish, dairy products with added vitamin D, egg yolks, and beef liver are all sources of the nutrient. However, many people may not get enough sun exposure or consume sufficient amounts of these foods to meet their daily requirements. Recommended Daily Intake Guidelines Infants: 400 IU (10 mcg) per day for ages 0–12 months. Children and adolescents: 600 IU (15 mcg) per day for ages 1–18 years. Adults: Men and women aged between 19-70 years should aim for an intake of at least 600 IU (15 mcg) per day, while those over the age of 70 require a slightly higher amount - around 800 IU (20 mcg). If you suspect that your fatigue symptoms might be related to a lack of this essential nutrient, consider ordering a comprehensive lab test like the one offered by DiscountedLabs.com which includes tests such as total testosterone, thyroid function, and vitamin D levels to help you get an accurate diagnosis and start feeling more energized. It is imperative to be aware of the sources and prescribed daily amount of Vitamin D, as a deficiency can have an effect on energy levels. Moving on from there, we will discuss testosterone's role in energy and fatigue as well as its symptoms and treatment options for restoring hormonal balance. "Boost your energy levels with Vitamin D. Get tested for deficiencies and take control of your health with Discounted Labs. #vitaminddeficiency #healthylifestyle" Click to Tweet Testosterone's Role in Energy and Fatigue Testosterone plays a significant role in maintaining high energy levels, making it essential to assess total testosterone along with free testosterone, especially among men experiencing unexplained tiredness or fatigue over time. Realizing the association between hormone amounts and tiredness can help in forming management plans for a better quality of life. Symptoms of Low Testosterone Low testosterone levels can lead to various symptoms such as decreased libido, erectile dysfunction, mood swings, and chronic fatigue. It is crucial to recognize these signs early on so that appropriate interventions can be implemented. If you suspect low testosterone may be contributing to your fatigue symptoms, consider getting a free and total testosterone test. Fatigue: Unexplained tiredness despite adequate sleep. Mood changes: Irritability or depression without any apparent cause. Sleep disturbances: Difficulty falling asleep or staying asleep throughout the night. Lack of motivation: Decreased interest in daily activities or hobbies once enjoyed. Treatment Options to Restore Hormonal Balance If your test results indicate low testosterone levels are causing your fatigue symptoms, several treatment options could help restore hormonal balance. These include lifestyle modifications like regular exercise and proper nutrition, along with medical treatments such as testosterone replacement therapy (TRT). Prior to beginning any treatment plan, it is important to consult a healthcare professional for tailored advice based on your individual requirements and medical history. Low testosterone can lead to energy and fatigue issues, so understanding the symptoms and available treatments is essential. Evaluating adrenal function can also help to ensure optimal stress response, which involves understanding how cortisol affects overall health as well as balancing other hormones produced by the adrenals. "Combat fatigue with a simple lab test. Assess your testosterone levels and explore treatment options for improved energy and quality of life. #LowT #Fatigue #HealthTips" Click to Tweet Evaluating Adrenal Function for Optimal Stress Response Adrenal function tests, such as cortisol and DHEA-S, are essential for understanding the body's stress response and energy levels. These tests provide valuable insights into potential underlying causes behind persistent fatigue symptoms, allowing you or your healthcare provider to better understand how to manage and treat them effectively moving forward. How Cortisol Affects Overall Health The adrenal glands release the hormone cortisol in response to stress. It plays a crucial role in regulating blood sugar levels, immune function, inflammation, and even mood. However, chronic stress can lead to an imbalance of cortisol production - either too much or too little - which may contribute to fatigue symptoms. High cortisol levels have been linked with insomnia and anxiety, while low cortisol levels are associated with chronic fatigue syndrome (source). Therefore, it's important to assess your adrenal function through lab tests like those available on DiscountedLabs.com. The Importance of Balanced Adrenal Hormones DHEA-S: Dehydroepiandrosterone sulfate (DHEA-S) is another hormone that the adrenal glands produce and that acts as a precursor to both testosterone and estrogen. DHEA-S has been shown to support immune function, cognitive abilities, and bone density, among other vital functions within our bodies (source). Low DHEA-S levels could be indicative of poor adrenal function and contribute to fatigue. Adrenal balance: Maintaining a healthy balance between cortisol and DHEA-S is essential for overall well-being. Imbalances in these hormones can lead to chronic fatigue, mood disorders, or other health issues. Regular testing of adrenal function helps identify any imbalances early on so that appropriate interventions can be implemented. Proper adrenal function is essential for optimal stress response and can be evaluated through a variety of lab tests. It is important to also identify sources of inflammation, such as the Epstein-Barr virus, which may contribute to fatigue, in order to create an effective treatment plan. "Take control of your fatigue symptoms with Adrenal Function Tests from Discounted Labs. Evaluate cortisol & DHEA-S levels for optimal stress response." #AdrenalFunctionTests #FatigueSymptoms #DiscountedLabs Click to Tweet Inflammation, Epstein Barr Virus, and Their Connection to Fatigue Inflammation can be a significant contributor to fatigue. C-reactive protein (CRP) measures inflammation levels in the body, which helps identify acute or ongoing inflammatory issues. The Epstein Barr Virus is known for causing mononucleosis, a condition that leads to extreme tiredness. Testing for this virus could help determine if it may be contributing to your low energy levels. Identifying Sources of Inflammation through CRP Testing C-reactive protein (CRP) is produced by the liver in response to inflammation. High levels of CRP indicate an increased presence of inflammation within the body, which can contribute significantly to chronic fatigue symptoms. By measuring CRP levels through blood tests, healthcare providers can identify potential underlying causes of persistent exhaustion and develop appropriate treatment plans accordingly. Symptoms Associated with Mononucleosis Caused by Epstein Barr Virus The Epstein-Barr virus often results in mononucleosis, also known as "mono" or "the kissing disease." This viral infection typically presents with symptoms such as: Fever Sore throat Swollen lymph nodes in the neck and armpits Extreme fatigue Muscle weakness and aches Headaches Rash (in some cases) If you are experiencing persistent fatigue, it's essential to consider the possibility of an Epstein-Barr virus infection. Discussing your symptoms with a healthcare provider and undergoing appropriate testing can help determine if this virus may be contributing to your chronic exhaustion. You can buy an Epstein-Barr virus antibody panel at DiscountedLabs.com. "Take control of your fatigue. Identify potential causes through CRP testing for inflammation levels and Epstein Barr Virus screening. #healthyliving #labtesting" Click to Tweet FAQs in Relation to Labs for Fatigue What labs should be checked for fatigue? To diagnose the cause of fatigue, a healthcare professional may recommend several lab tests, including Complete Blood Count (CBC), Iron Level Testing, Vitamin B12 & Folate Deficiencies Assessment, TSH Test, Free T3 & Free T4 Test, Thyroid Antibodies Testing, Total and Free Testosterone Testing, Cortisol Testing, DHEA-S Testing, Fasting Glucose Test, Fasting Insulin Test and Hemoglobin A1c (HbA1C). What does a fatigue blood test show? A fatigue blood test helps identify potential causes of persistent tiredness by evaluating various factors such as anemia (low red blood cell count), iron deficiency or overload (source), thyroid function abnormalities (source), vitamin deficiencies, hormonal imbalances (source), adrenal dysfunction (source), glucose regulation issues (source) and inflammation (source). Conclusion In conclusion, fatigue is a complex issue with multifactorial causes. Labs for fatigue can help identify underlying medical conditions such as anemia, thyroid dysfunction, hormonal imbalances, vitamin deficiencies, and inflammation that may contribute to persistent tiredness. By assessing the source of fatigue through laboratory tests, individuals can collaborate with their healthcare providers to devise tailored regimens that address their individual needs. If you're experiencing chronic fatigue symptoms and want to take control of your health and wellness journey, DiscountedLabs.com offers discounted panels for labs related to fatigue management. Take charge of your health today by visiting DiscountedLabs.com.

Table of Contents What is Inflammation? What Are the Health Consequences of Chronic Inflammation? What Are the Common Inflammation Tests? C-Reactive Protein (CRP) – CK- Creatine Kinase (or Creatine Phosphokinase – CPK) - Ferritin - Homocysteine - Lactic Acid Dehydrogenase (LDH) - Erythrocyte Sedimentation Rate (by Westergren) (ESR) - Buy DiscountedLabs.com Inflammation Tests Panel Here What is Inflammation? Not inherently good or bad, Inflammation is the process recruiting immune cells to tissues in the body for immunity, repair and cell defense. Excessive levels can cause joint pain, inflammatory bowel disease, increased risk of several illnesses, and accelerate signs of aging and disease pathology such as cancer or obesity. The function of inflammation is to eliminate the initial cause of cell injury, clear out cells and tissues damaged from the original insult, and to initiate tissue repair. What Are the Health Consequences of Chronic Inflammation? The classical signs of inflammation are heat, pain, redness, swelling, and loss of function. Inflammation is a generic response, and therefore it is considered as a mechanism of innate immunity, as compared to adaptive immunity, which is specific for each pathogen. Too little inflammation could lead to progressive tissue destruction by the harmful stimulus (e.g. bacteria) and compromise the survival of the organism. In contrast, chronic inflammation may lead to a host of diseases, such as hay fever, periodontitis, atherosclerosis, rheumatoid arthritis, and even cancer. Inflammation is therefore normally closely regulated by the body. What Are the Common Inflammation Tests? There are several tests that can help assess if inflammation occurs and where it may be occurring even with no symptoms: C-Reactive Protein (CRP) – CRP is a substance produced by the liver that increases in the presence of inflammation in the body. This test helps to diagnose and monitor the activity of some inflammatory and infectious conditions. Arterial damage results from white blood cell invasion and inflammation within the wall. CRP is a general marker for inflammation and infection, so it can be used as a very rough proxy for heart disease risk. The American Heart Association and U.S. Centers for Disease Control and Prevention have defined risk groups based on CRP as follows: Low Risk: less than 1.0 mg/L, Average risk: 1.0 to 3.0 mg/L, High risk: above 3.0 mg/L. CRP can also be increased by sleep apnea, rheumatoid arthritis, colon cancer and inflammatory bowel disease. CK- Creatine Kinase (or Creatine Phosphokinase – CPK) - Creatine phosphokinase is an enzyme found mainly in the heart, brain, and skeletal muscle. It is tested by taking a blood sample. High CPK can indicate muscle destruction and inflammation, heart attacks, central nervous system issues, and others. Ferritin - Serum ferritin is used as a screening tool to detect iron deficiency. Serum ferritin values in the range of 200–2000 ng/ml may be increased due to non-iron-related factors including elements of inflammation and obesity. Homocysteine - A high level of homocysteine in the blood (hyperhomocysteinemia) makes a person more prone to endothelial cell injury, which leads to inflammation in the blood vessels, which in turn may lead plaque build-up inside blood vessels. Hyperhomocysteinemia is therefore a possible risk factor for coronary artery disease since it has been correlated with the occurrence of blood clots, heart attacks and strokes. Lactic Acid Dehydrogenase (LDH) - LDH is an enzyme, or catalyst, found in many different tissues in your body that is involved in energy production. These include your red blood cells, skeletal muscles, hert, kidneys, brain, and lungs. LDH is most often measured to check for tissue damage. LDH is in many body tissues, especially the heart, liver, kidney, muscles, brain, blood cells, and lungs. An elevated level of LDH may be seen with: Anemia, infections (such as infectious mononucleosis (mono), meningitis, encephalitis, and HIV), sepsis, intestinal and lung (pulmonary) infarction, kidney disease, liver disease, muscle injury, pancreatitis, cancers and bone fractures. Erythrocyte Sedimentation Rate (by Westergren) (ESR) - ESR is the rate at which red blood cells sediment in a period of one hour. To perform the test, anticoagulated blood was traditionally placed in an upright tube, known as a Westergren tube, and the rate at which the red blood cells fall was measured and reported in mm/h. The ESR is increased in inflammation, pregnancy, anemia, autoimmune disorders (such as rheumatoid arthritis and lupus), infections, some kidney diseases and some cancers (such as lymphoma and multiple myeloma). The ESR is decreased in polycythemia, hyperviscosity, sickle cell anemia, leukemia, low plasma protein (due to liver or kidney disease) and congestive heart failure. Buy DiscountedLabs.com Inflammation Tests Panel Here

Table of Contents What is inflammation? How does inflammation happen? Acute and chronic inflammation Acute inflammation signs Chronic inflammation Chronic inflammation and heart disease How to find out if one has chronic inflammation Causes of chronic inflammation Measuring inflammation blood markers using an inflammation test panel How does the inflammation panel work? What blood markers does an inflammation panel measure? C-reactive protein Creatine kinase or creatine phosphokinase Ferritin Symptoms of Low Ferritin: Symptoms of High Ferritin: Normal Ranges of Ferritin Blood Levels Low ferritin causes High ferritin causes Homocysteine Symptoms of high levels of homocysteine: Health problems caused by high homocysteine levels Lactic Acid Dehydrogenase What do high LDH levels mean? Erythrocyte Sedimentation Rate Symptoms of abnormal ESR levels Adjusting your diet to prevent chronic inflammation Treating chronic inflammation How to prevent chronic inflammation naturally? What to do next? What is inflammation? Inflammationrepresents the body’s natural response to cure wounds and different forms of injury. This is a normal and healthy process which helps to heal damaged tissues or eliminating foreign invaders (such as microbes and viruses). Inflammation is a good thing. Without it, wounds can expand and become deadly in a short period. However, when inflammation remains in the body for too long or takes place in body areas which don’t need it, inflammation can become a problem.   How does inflammation happen? When the body detects foreign invaders, it quickly releases a stream of proteins and white blood cells to neutralize them. These white blood cells (also known as phagocytes) surround the invaders (microbes, bacteria, and viruses) and prevent them from multiplying or causing damage to the body. This happens when one has a fever. The body temperature rises significantly because the body detects foreign invaders and attempts to neutralize them. Fever is a good thing, and it is one of the best inflammatory responses of the body because it protects us against a wide range of viruses that can cause serious health problems.   Acute and chronic inflammation Acute inflammation happens when someone has a sore throat or a sprained ankle. This type of inflammation is characterized by localized effects and temporary responses. The body knows exactly where the damage occurred, and it sends white blood cells to heal the injured tissues.   Acute inflammation signs The symptoms of acute inflammation are very popular and easy to recognize: · Redness · Soreness · Fever · Swelling · Loss of function · Mild pain When acute inflammation happens, the blood vessels expand to let more blood come to the damaged area for healing purposes. The damaged tissue releases substances called cytokines which act as signals, instructing the body to send more nutrients and hormones to this area. This will speed up the healing process and completely neutralize foreign invaders.   Chronic inflammation Chronic inflammation has whole-body effects, and it usually happens over long periods. This type of inflammation is persistent, and it is characterized by an increase of inflammatory markers in the body. Chronic inflammation can lead to serious diseases, and it is a slow, steady process which develops over many years. As mentioned early, when the body detects foreign invaders, it releases a swarm of white blood cells to neutralize them. With low-level inflammation usually encountered in chronic inflammation, the body believes that there is a foreign invader or an illness to cure, when in fact there isn’t any. The white blood cells are sent to the perceived damaged tissue, but they have no foreign cells to neutralize, and they eventually start to attack nearby cells, tissues or organs. Although this process is not yet completely understood, researchers are trying to understand why phagocytes attack healthy internal cells and how this process leads to the development of serious diseases such as heart disease or cancer.   Chronic inflammation and heart disease Statistics show that heart disease and stroke are closely linked to patients of all ages. Some researchers believe that when the inflammatory cells (white cells) stay in the blood vessels for a long period, they help the development of plaque. Plaque is a substance formed inside blood vessels. The body might see it as a foreign invader and instructs white blood cells to neutralize it. This leads to a large accumulation of phagocytes inside blood cells around the plaque. When plaque buildup gets too thick, it might rupture inside a blood vessel and cause clots which block blood from passing to vital organs such as the brain. This can lead to serious cardiovascular diseases, including a stroke. Chronic inflammation can also lead to cancer. This might happen because low-level inflammation can cause irreversible DNA damage which facilitates the development of different types of cancers.   How to find out if one has chronic inflammation Chronic inflammation usually doesn’t have symptoms. If they exist, these can be: · Fever · Mouth sores · Abdominal and chest pain · Rashes · Fatigue Some symptoms of chronic inflammation can last for several months or even years. Doctors can also look for certain inflammation markers as part of an inflammation panel to determine if one experiences low-level inflammation. For example, high levels of C-reactive protein can indicate chronic inflammation in people of all ages. It can be measured via a simple blood test. There are other markers which can indicate inflammation, and they will be explained in detail later on in this article.   Causes of chronic inflammation Maintaining a healthy lifestyle with plenty of exercise and a nutritious diet can lower one’s chances of developing chronic inflammation. Getting regular health checks is also important to prevent dangerous diseases. Apart from an unhealthy diet, there are other things which might cause chronic inflammation:  Long exposure to irritants and pollutants – people who work with chemicals are particularly exposed, and they have a higher risk of developing chronic inflammation  Untreated injuries – wounds or injuries which are not treated or improperly treated can become more severe and cause chronic inflammation Autoimmune disorders such as lupus and rheumatoid arthritis There are also certain factors which contribute to the development of chronic inflammation such as:  Smoking  Drinking too much alcohol  Dealing with high amounts of stress daily  Being overweight or obese Measuring inflammation blood markers using an inflammation test panel An inflammation panel can help to measure certain blood markers, including C-reactive protein, to determine the amount of inflammation in the body. Such tests are performed on a simple blood sample offered by the patient. They are highly accurate and provide accurate insights into one’s overall health.   How does the inflammation panel work? Testing inflammation markers can be easily done using online test panels. Ordering an online panel means that you don't have to ask your doctor for one, such tests are delivered directly to the consumer and they are processed in the same labs as the ones ordered by doctors. Here is the step-by-step process: 1. You order your inflammation panel online and receive an appointment at a nearby lab to draw blood for your test. 2. Once you have offered your blood sample, it will be tested at the lab and the results will be delivered to you in a few business days 3. You can measure the test results against reference values and determine if your markers are in normal ranges or not 4. You can also receive appropriate recommendations from your healthcare provider based on these results 5. You make healthy lifestyle adjustments to lower inflammation levels (if necessary) and prevent serious diseases such as lupus, high blood pressure, heart diseases and so on.   What blood markers does an inflammation panel measure? An inflammation panel is highly recommended for obtaining valuable health insights because it can measure a wide variety of markers to obtain a highly accurate result. The substances measured by an inflammation panel include C-reactive protein, creatine kinase, ferritin, homocysteine, lactic acid dehydrogenase and erythrocyte sedimentation rate.   C-reactive protein This substance is produced by the liver is one of the most important inflammation markers in the body. It is usually an indicator of heart problems or arterial damage. The American Heart Association created risk groups depending on C-reactive protein and they can be used to determine the inflammatory risk of a particular patient. For example, CRP (C-reactive protein) levels below 1.0mg/L indicate low risk. Levels between 1.0mg/L and 3.0mg/L indicate average risk while CRP levels above 3.0 indicate high risk. There are certain health conditions which can increase the levels of CRP in the body such as inflammatory bowel disease, sleep apnea, colon cancer and more. It is important to determine the exact levels of CRP in the body to prioritize treatment for those who have high levels. As mentioned earlier, high levels of CRP are closely linked with heart diseases. Those who have more than 2.0mg/L of CRP in the bloodstream might require more intense treatment of heart problems. Patients who have high levels of CRP might also require quicker doctor follow-ups for treating heart ailments as well as receiving higher priority for heart surgeries. CRP levels higher than 10mg/L indicate more serious health problems and require further testing. Such high inflammation in the body can be caused by bone infections, lupus, connective tissue disease, cancer or pneumonia. It is important to mention that CRP levels might be high in women who take birth control pills. However, other blood markers for infection would have normal values in this case. Having high CRP levels in the bloodstream might indicate a significant risk for cardiovascular or autoimmune disease, but this is just one biomarker and doesn’t show the full picture. Additional testing is required to determine if heart disease is a concern for the patient in question. Testing the CRP levels through an inflammation panel is the first step towards a better health insight, and it will help patients make more informed decisions. If the CRP levels are shown to be elevated, doctors might prescribe switching to a Mediterranean diet which has been shown to decrease CRP levels over time.   Creatine kinase or creatine phosphokinase Creatine kinase (CPK) is found in numerous tissues and organs in the body including muscle, brain, and heart. It is an enzyme which can indicate inflammation and deterioration of tissues if it is present in high quantities in the bloodstream. CK has a great activity in muscle tissue, and it is usually found in plasma, serum or urine. During muscle deterioration, CK gets out from muscle cells and enters the bloodstream. This makes the blood CK levels to be elevated and indicate muscle damage. Normal CK levels vary with age, gender, and other factors. Most people should have a CK level between 22 and 198 u/L. Higher amounts might indicate chronic inflammation and require further investigation to determine its source. It can also indicate acute muscle injury. It is important to mention here that muscle deterioration is normal for people who work out regularly, especially those who do heavy resistance training. During intense workouts when someone lifts heavy weights, the muscle tissues get damaged at a microscopic level. This is called muscle catabolism, and it is a completely normal process. This is the moment when CK rises to the surface from muscle cells and enters the bloodstream. Therefore, a higher CK level is normal for people who are regular lifters, but if the CK amount is still higher than 198 u/L, then this might indicate a bigger problem. Before testing the CK levels, it is paramount for the patient to significantly reduce workout routines to prevent excessive amounts of CK from entering the bloodstream and impairing the results. CK tests are used to evaluate primarily neuromuscular diseases. This means that the test will reveal if the symptoms a person is experiencing are caused by muscle weakness or a nerve problem. Testing the CK levels can also provide important information such as differentiating between certain types of muscle disorders. CK levels higher than 500 u/L can indicate certain nerve disorders which need proper treatment. Some of these ailments include Charcot-Marie-Tooth disease or spinal muscular atrophy. When the levels of CK are between 3,000 u/L and 5,000 u/L, this can indicate inflammatory myopathies. CK levels higher than 50,000 u/L can indicate problems such as acute muscle breakdown.   Ferritin Ferritin is another biomarker measured by the inflammation panel. It is a protein which stores iron and releases it later on when it is necessary. This substance can be found primarily in body cells, and most of them are situated in the liver. The liver cells which contain ferritin are known as hepatocytes. Ferritin is involved in the production of red blood cells. When ferritin is required in the body, it will combine with transferrin to be transported to the place where red blood cells need to be produced. Ferritin is different from iron. Ferritin is a protein which stores iron and plays an important role in a person’s overall iron levels in the body. Iron is required to carry oxygen throughout the body. When someone has an iron deficiency, testing the ferritin levels (stored iron) shows the complete iron picture. The same test can be done when someone has too much iron in the body as well. A healthy person is required to have enough circulating iron as well as stored iron levels (ferritin). Symptoms of Low Ferritin: Dizziness Weakness Headaches Fatigue Leg pains Irritability Ringing in the ears Symptoms of High Ferritin: Joint pain Stomach pain Heart palpitations Fatigue Ferritin levels might be increased by damage to vital organs such as the liver or spleen. The ferritin test will produce certain results which will be compared with standard reference values.   Normal Ranges of Ferritin Blood Levels · the normal ferritin levels for men are between 20 and 500 ng/mL · the normal ferritin levels for women are between 20 and 200 ng/mL If the patient has abnormal ferritin levels, he or she might receive appropriate health recommendations to bring ferritin levels back to normal.   Low ferritin causes One of the most common causes of low ferritin consists of iron deficiency. This means that a person doesn’t get enough iron from his or her diet. It is important to note here than iron can also be taken from supplements, so one shouldn’t necessarily rely just on getting it from foods. Anemia might also be an important cause of low ferritin levels. Anemic people don’t have enough red blood cells for iron to bind with, and this condition usually have excessive fatigue and dizziness as symptoms. Other causes of low ferritin levels include intestinal absorption, internal bleeding or menstrual bleeding. It is important to know the exact levels of ferritin and iron in the body to make a more accurate diagnosis. For example, those who have chronic diseases can have low iron levels but normal ferritin levels, while people with anemia have both low iron and ferritin levels.   High ferritin causes Having too much iron stored in the body isn’t a good thing either. An excessive amount of iron in the body can significantly increase ferritin levels. This can be caused by various health conditions or diseases such as: hyperthyroidism diabetes type 2 leukemia rheumatoid arthritis liver disease High ferritin levels can also be caused by different types of cancers. People who have certain liver diseases might experience increased ferritin levels because ferritin is concentrated in liver cells. When liver tissue gets damaged, ferritin starts to leak out, and it will be detectable in the bloodstream.   Homocysteine Homocysteine is an amino acid commonly found in the blood. Its levels rise in the bloodstream when one eats meat. Abnormal levels of homocysteine might indicate an early onset of heart disease. High homocysteine levels can also make one more predisposed to endothelial injury. Endothelial injury is damage done to the inner lining of blood vessels. This usually can be found in people who have heart diseases. Endothelial injury can promote the development of plaque inside blood vessels which can cause stroke in the long run. High levels of homocysteine are called hyperhomocysteinemia, and it is a risk factor for heart problems such as coronary heart disease. hyperhomocysteinemia is also closely correlated with other cardiovascular problems such as blood clots and heart attacks. Normal homocysteine levels in the blood are usually below 15 mmol/L. Higher levels demand a further investigation to determine if there is a significant risk for heart disease. High levels of homocysteine are usually associated with a deficiency of vitamin B12. This condition doesn’t show symptoms in adults, but it can show symptoms in kids, although these are very discreet.   Symptoms of high levels of homocysteine: fatigue mouth sores dizziness mood changes tingling sensations in limbs pale skin weakness The main causes of elevated homocysteine levels can be linked to genetics or kidney disease. Taking certain medications can also increase the amount of these amino acids in the bloodstream. Low thyroid hormones and psoriasis can also cause high homocysteine levels. It is important to test this biomarker to determine the level of inflammation in the body more accurately. For example, if one has high CRP levels (C-reactive protein) as well as high homocysteine levels, this can be a strong indication of a potential heart disease at some point in the future.   Health problems caused by high homocysteine levels If homocysteine levels are high for a long period and they are left untreated, this can lead to certain health complications such as: thrombosis – clots develop inside blood vessels and affect circulation heart attack coronary artery disease dementia Alzheimer’s disease osteoporosis Bringing homocysteine levels to normal values can be done in several ways, and one of the most popular methods consists ofgetting daily vitamin supplements. As mentioned earlier, elevated levels of homocysteine can be caused by vitamin B12 deficiency, so taking a vitamin B12 supplement and eating more foods containing vitamin B12 can lower homocysteine. Orange juice, beans, and green vegetables are full of vitamin B12, and they can be enjoyed daily by people of all ages.   Lactic Acid Dehydrogenase Lactic acid dehydrogenase (LDH) is an enzyme which plays a vital role in the body’s energy production. This enzyme helps to turn blood glucose (sugar) into energy which will be absorbed by cells to function properly. LDH is also found in many cells, tissues, and organs such as heart, kidneys, brain, skeletal muscle, lungs, etc. Testing the LDH levels is important because this biomarker is a strong indicator of tissue damage. High levels of LDH can be seen in people who have anemia, sepsis, lung inflammation, liver disease, chronic muscle injury and more. When the body detects illness or an internal injury, the levels of LDH increase drastically. Measuring these levels helps doctors determine if the inflammation is acute or chronic as well as coming up with a more accurate diagnosis. There are five different types of LDH isoenzymes spread out across the entire body in different concentrations. For example: LDH 1 and LDH 2 can be found in red blood cells and the heart LDH 3 can be found in the pancreas and lungs LDH 4 and LDH 5 can be found in skeletal muscle and the liver Elevated levels of LDH can be caused by various factors such as: Stroke or heart attack Cancer Problems with blood flow Hepatitis Muscle injury Sepsis Chronic tissue damage Measuring the levels of LDH in the body is necessary to diagnose certain types of inflammations and diseases. It is important to follow certain requirements before performing the test, to ensure that the results are as accurate as possible. For example, vitamin C can lower LDH levels, so patients should get too much vitamin C a few days before taking the test. Heavy exercise should also be avoided since it can increase LDH levels. Similarly, alcohol can increase LDH levels, so patients are asked to refrain from drinking alcohol a couple of days before taking the test. Normal LDH levels for adults is 100–190 U/L. It is important to note here that kids will have much higher values and it is normal to be so. For example, small children up to 2 years old can have LDH levels between 180 and 430 U/L.   What do high LDH levels mean? Since LDH is present in so many body cells, tissues and organs, high LDH levels indicate inflammation, but more precise tests are required to determine exactly where it occurs. For example, LDH 4 and LDH 5 indicate muscle and liver damage, so further investigations are necessary. Doctors might request a full liver panel to determine if the inflammation occurs precisely in the liver or the skeletal muscle. Low LDH levels are very rare, and they are usually harmful. These might be caused by people who consume too much vitamin C (which lowers LDH levels) or by people who have rare genetic mutations.   Erythrocyte Sedimentation Rate Erythrocyte sedimentation rate (ESR) is another biomarker tested by an inflammation panel. It represents the rate at which blood cells sediment in one hour. This test is performed by putting anticoagulated blood in a vertical tube (aka Westergren) and waiting for them to settle at the bottom of the recipient. The rate at which the blood falls to the bottom is known as ESR, and it is measured in millimeters per hour. Elevated levels of ESR are usually found in people who have different types of diseases such as autoimmune disease, anemia, kidney disease, cancer, and other health complications. Similarly, low levels of ESR can also indicate certain diseases such as blood hyperviscosity, low plasma protein, leukemia and more.   Symptoms of abnormal ESR levels When the ESR levels in the bloodstream are outside normal ranges, the patient might experience certain symptoms such as the following ones: Abnormal weight loss Headaches Joint pain and stiffness Neck or shoulder pains Diarrhea and fever Testing the ESR levels can give the patient an important “heads up” when it comes to his or her health. However, it is important to discontinue taking certain medications or drugs a couple of days before the test, to prevent them from interfering with the baseline ESR levels. For example, the patient shouldn’t take: Androgens and estrogens Dextran Hypertension medication Oral contraceptives Aspirin Cortisone Antipsychotic drugs The ESR test is usually done in combination with a CRP test to get more accurate results. Both these tests are included in a standard inflammation panel.   Adjusting your diet to prevent chronic inflammation As mentioned earlier, a nutritious diet based on healthy foods can significantly lower body inflammation and prevent a wide variety of diseases. There are certain foods or ingredients which promote inflammation, and they should be avoided. Sugar is one of the best examples in this case. To manage chronic inflammation or prevent it altogether, one should include the following foods in his or her diet: · Fruits such as oranges and cherries · Tomatoes · Leafy greens such as spinach and kale · Olive oil · Fatty fish such as salmon These goods help lowering inflammation levels in the body, not to mention that they are delicious and nutritious. Similarly, there are certain foods which need to be avoided: · Red meat · Processed meat such as hot dogs, salami and sausages · Fried foods including French fries · White bread · Pastries · Refined sugars such as chocolate, ice cream, and candies   Treating chronic inflammation A good amount of inflammation can protect the body against a wide variety of diseases and viruses. However, when too much inflammation is detected in the body, certain medication might help to manage its symptoms. For example, certain foods have anti-inflammatory effects on the body. These foods include garlic, curcumin, ginger, and cayenne, among others. Garlic, in particular, is known to fight viruses and bacteria as well as drastically reducing body inflammation. Corticosteroids can also be used to treat chronic inflammation. These hormones are helpful to suppress the function of the immune system for a short period, so that it doesn’t attack healthy tissues (as in the case of autoimmune diseases) However, long-term usage of corticosteroids can lead to other health problems such as high blood pressure and osteoporosis, so these hormones should be administered with care. Nonsteroidal anti-inflammatory drugs can also be used to manage chronic inflammation. These drugs include ibuprofen, aspirin, naproxen, and others. The good thing is that they reduce inflammation and pain. The bad thing is that abusing these drugs can lead to kidney disease or other health conditions, so they should be administered with care.   How to prevent chronic inflammation naturally? On top of taking corticosteroids or nonsteroidal anti-inflammatory drugs as instructed by a doctor, one can also prevent or reduce acute and chronic inflammation naturally. The best way to do this is by switching to a healthier diet which is rich in anti-inflammatory foods. Some of these foods were mentioned above (garlic, fruits, etc.), but the list of good foods also include walnuts, flaxseed, soybeans, and tofu. Other methods of preventing inflammation naturally involve losing weight through exercise. Each person should make a habit of exercising for at least 10-15 minutes a day several times a week. People who are overweight are more prone to inflammation, and they can develop serious medical conditions at an earlier age. Inflammation can also be reduced by reducing stress levels. Stress is an unavoidable part of life, but people should learn to compensate through extended relaxing periods. There are numerous ways one can relax and eliminate stress such as going for a walk, doing yoga, reading, meditating, watching a good movie, swimming, biking, listening to good music (particularly symphonic music) and more. Another excellent way of reducing inflammation naturally consists of drinking lots of water. The human body is bombarded every day with tons of toxins from different sources including cosmetic products, food chemicals, perfumes and scents, pesticides, insecticides, cigarette smoke, pollution and more. By drinking lots of water daily, the body manages to make these toxins move and eliminates them through urine and stool. As a result, they don’t accumulate in the body, and they don’t promote the development of life-threatening diseases such as diabetes type 2, coronary heart disease and lupus. Finally, getting a good night’s sleep or even a quick nap in the middle of the day can do wonders for the body and help it fight viruses and bacteria more efficiently. People shouldn’t ignore their rest time regularly since lack of sleep can lead to weight gain, poor mental performance and even decreased sex drive.   What to do next? Remember that measuring inflammation biomarkers is very important to discover certain chronic inflammation patterns in the body. Untreated chronic inflammation can lead to life-threatening medical conditions. By testing the biomarkers, one knows in advance whether he is predisposed to certain diseases or not and can make appropriate lifestyle changes if necessary. Order the inflammation panel now and have more peace of mind in the future!