Biotin supplements taken at common over-the-counter doses can interfere with the results of certain hormone assays, giving falsely high or low results that could lead to a misdiagnosis, researchers reported. Biotin supplements, at very large doses, 10-15mg (333-fold greater than the dietary recommendation), have become popular for the presumptive benefits of stimulating hair growth, diabetes, lipid disorders, and diabetic peripheral neuropathy. 

High doses of biotin may interfere with lab tests because biotin is a common component of many immunoassays in the form of biotinylated antibodies or analogs. If you are taking a biotin supplement, please stop it at least 4 days before getting your blood drawn. Biotin supplements taken at common over-the-counter doses can interfere with the results of certain hormone assays, giving falsely high or low results that could lead to a misdiagnosis. Biotin supplements, at very large doses, 10-15mg (333-fold greater than the dietary recommendation), have become popular for the presumptive benefits of stimulating hair growth, diabetes, lipid disorders, and diabetic peripheral neuropathy. High doses of biotin may interfere with lab tests because biotin is a common component of many immunoassays in the form of biotinylated antibodies. 



Clinicians may want to ask about biotin ingestion even if assay results are not suspect because biotin interference can cause either falsely not or abnormal results. It may be advisable for patients to stop taking biotin, preferably for a week...before undergoing laboratory testing.


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