Testosterone Tests

Is 2ml of Testosterone a Week Enough to Build Muscle? Study Results Testosterone is a hormone that plays many roles in the body, like building muscle, increasing strength, sexual health, and overall well-being. People wonder how much testosterone is needed to achieve these benefits, especially when considering testosterone replacement therapy (TRT) for muscle growth. Those with low testosterone might be considering TRT to feel better. But figuring out the right testosterone dose to use is tricky because it depends on your age, health, diet, exercise program, and how your body reacts to the treatment. In this article we will be looking at a study by Dr. Bhasin and his colleagues in 2001 published in the American Journal of Physiology and Endocrinology Metabolism. Their study was to see how different amounts of testosterone affect young men and what’s the best dose for different results. By going through what they found out we can learn a lot about what’s the right amount of testosterone for getting stronger or building muscle. Watch video here: What is the Optimal Testosterone Dose? Testosterone and Muscle Growth Testosterone is a hormone that plays a big role in muscle growth and development. Produced mainly in the testicles in men, testosterone is responsible for the development of male characteristics, including muscle mass and strength. As men age, their testosterone levels decline naturally, which can lead to a decrease in muscle mass and strength. This decline can affect overall health and well-being, so it’s important to understand the connection between testosterone and muscle growth. For those who want to build muscle, maintaining optimal testosterone levels is crucial. Testosterone stimulates protein synthesis, which is the process by which the body repairs and builds muscle tissues. Higher testosterone levels can increase muscle mass, strength, and overall health. By understanding how testosterone affects muscle growth, you can make informed decisions about your fitness and health goals. Testosterone Replacement Therapy (TRT) for Muscle Growth Testosterone Replacement Therapy (TRT) is a treatment for those with low testosterone. TRT involves injecting, gelling, or patching testosterone to restore normal testosterone levels. This is especially good for those experiencing symptoms of low testosterone such as decreased muscle mass, fatigue, and decreased libido. TRT can increase muscle mass and strength, bone density, and overall health. By restoring testosterone levels, TRT supports the body’s natural ability to build muscle and perform physically. But please note that TRT should only be done under the guidance of a doctor. While TRT can be beneficial, it also has side effects and risks, like increased red blood cell production and changes in cholesterol levels. So medical supervision is necessary to ensure safe and effective treatment. The Study In the study, about 65 young men around 25 years old and in good shape were studied. The study also included 1 ml of testosterone as part of the dosage variations. First they stopped their bodies from making testosterone naturally by giving them a drug that blocks testosterone. Then for 20 weeks they gave these men shots of a type of testosterone called cypionate once a week. The dose varied from 25 milligrams to 600 milligrams a week. By doing this, they could see how different doses affect different things. Testosterone Dose and Hormone Levels The study found a correlation between the dose of testosterone and the levels of different hormones in the body. They looked at total testosterone, free testosterone, LH (luteinizing hormone), SHBG (sex hormone-binding globulin), and IGF-1 (insulin-like growth factor 1). Here’s what they found out: As the dose of testosterone increased, so did the total testosterone levels in the body. At the beginning, the subjects had testosterone levels of 500-600 ng/dL. By week 16, those who got higher doses (300-600 mg/week) had levels of 1300-2300 ng/dL. Even with a smaller dose of 125 mg/week, the subjects had levels near what they started with. So taking around 100-125 mg/week might be enough for young men to get their testosterone back to normal. Free testosterone: Just like total testosterone, as more was given, free testosterone increased. So more dosage means more free testosterone is available in your system. LH and SHBG: The more testosterone you take, the lower these levels go. As people increase their dose of testosterone, they see a drop in LH and also in SHBG. So taking more testosterone can slow down LH production and decrease SHBG. So more free testosterone is available for your body to use. Testosterone dosage for muscle growth and body composition The study looked into how different doses of testosterone affect muscle building, muscle size, and body composition. They used various methods to measure lean muscle mass (fat-free mass) and body fat. Here’s what they found out: For fat-free mass, the study found that 100-125 mg of testosterone per week helped people gain muscle without fat. Those who took these doses had less body fat and more muscle. Even more (300-600 mg/week) gave better results in gaining muscle without fat. But the smallest doses (25-50 mg/week) didn’t do much; sometimes they even added fat. For body fat, it seems that higher doses help reduce it. Those who got 100-125 mg per week lost body fat. Those who got very low doses (25-50 mg/week) didn’t lose weight or might have added body fat. So high levels of this hormone can make you leaner by cutting down fatty tissues while increasing muscle growth. Factors to Consider in Testosterone Dosage Determining the right testosterone dosage for TRT involves considering age, health status, and individual goals. Age is a big factor, as older men may need different dosages than younger men due to natural hormonal decline. Men with underlying health conditions such as cardiovascular disease or metabolic disorder may need customized dosages to ensure safety and effectiveness. Individual goals also matter in determining testosterone dosage. For example, someone looking to improve overall health may need a different dosage than someone looking to gain massive muscle and bodybuilding. Personalized treatment plans are necessary to address these individual needs and goals. Working with a doctor is key to determining the right dosage. Regular blood tests and monitoring can help adjust the dosage as needed to keep testosterone levels within normal range. By considering these factors and working with a medical professional, you can get the best out of your TRT. Testosterone Dose and Sexual Function and Libido The study also looked into how different doses of testosterone affect sexual function and desire. To find out they asked participants to fill out questionnaires about their sex life and how much they wanted sex. Here’s what they found out: For sexual activity, the study didn’t show much change in how often people were sexually active when they took more testosterone. The frequency of sexual encounters remained the same across all doses. Note that there were not many participants in this study, so this might have affected the results. For libido, it was found that 300-600 mg/week of testosterone gave a slight increase in desire. But 25-125 mg/week didn’t make much of a difference in libido. So higher doses used by bodybuilders might be more effective in increasing sexual desire. No Change in Cognitive Function In the study they also looked into how well people can think and remember. But even with different doses of testosterone, there was no big change in brain function. Note that this study was done on young guys. To know if testosterone affects thinking and memory in older men more studies need to be done. Testosterone Dose and Strength and Power In the study they tested the strength and power of participants’ legs by having them do leg press for 20 weeks. What they found out was interesting—the amount of testosterone given to the participants made a difference in how much stronger or more powerful their legs became. Those who got 300-600 mg/week had a significant increase in strength and power of their legs. So taking higher doses of testosterone can make you stronger and more powerful even if you don’t work out. Hemoglobin, Hematocrit and Cholesterol Levels Giving testosterone changes blood counts and fat levels in the body. The results match what we already know: Hemoglobin: As testosterone dose increased, so did hemoglobin levels. So as more testosterone is given more hemoglobin goes up. This means treatment with testosterone can affect erythropoiesis, which is how our body makes red blood cells. Just like hemoglobin, when testosterone doses go up, so does hematocrit. Hematocrit is all about how much space red blood cells take up in our blood. The study didn’t specify what’s the ideal level of hematocrit is, but note that too much can be bad for your heart health. Lipid Profile: The administration of testosterone caused a fluctuation in the levels of HDL cholesterol, the beneficial type. When you have more testosterone in your system, your HDL cholesterol tends to decrease. So it’s really important to monitor lipid profiles if you’re on testosterone therapy. Conclusion In 2001 Dr. Bhasin and his team did a study that looked into how different doses of testosterone affect several factors. Although the study was done on young men and had a small number of participants, it still gives us valuable information on how testosterone levels relate to muscle size, sexual health, brain function, physical strength, and blood-related measures. According to the study, 100-125 mg/week may be enough for young men to get their testosterone levels back to normal. For bodybuilding, 300-600 mg/week seems to increase muscle size, strength, and sex drive. But we have to remember that people react differently to each other. So any treatment with testosterone should be customized for each person’s needs and monitored by a healthcare professional who knows what he’s doing. Note that the study was done more than 20 years ago. Since then there might be new findings. If you’re thinking of testosterone therapy, talk to medical experts. They can assess your situation and give you personalized advice. The study provides valuable insights into the functioning of testosterone dosing, highlighting the need for further investigation. By doing more research, we can make the most of testosterone therapy and minimize the downsides. Get a budget-friendly testosterone test without seeing a doctor. Buy a testosterone test from DiscountedLabs.com and find out your testosterone blood level and adjust your TRT dose. FAQs Is 2 ml of testosterone a week enough to build muscle? The study above showed that 125 mg/week of injectable testosterone was enough to increase muscle. 2 ml of testosterone is 400 mg/week which will increase muscle but may cause high hematocrit, water retention, and blood pressure. How much test cypionate a week for bodybuilding? The study above showed that 125 mg/week of test cypionate is enough to increase muscle in bodybuilding without TRT side effects. References: In a study titled "Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study", researchers looked at how hormone levels, including testosterone, change as men get older. The article "Testosterone Replacement in Older Men: A Clinical Perspective" discusses the benefits and considerations of giving older men testosterone to improve their health. According to research found on Harvard's website, scientists have figured out what dose of testosterone works best for women. Another study called "Effects of Testosterone Treatment on Body Fat and Lean Mass in Obese Men on a Hypocaloric Diet: A Randomized Controlled Trial" explores how taking testosterone can help obese men lose fat but keep muscle while eating fewer calories.

Testosterone Injection: Subcutaneous vs. Intramuscular—Where to Inject Regardless of which TRT product you’ve been prescribed, a common question is where to inject testosterone. For decades, most men have used IM testosterone injections, primarily into the glutes, quads, or deltoids, using a 1 to 1.5-inch syringe. During the past five years, many men have also begun injecting testosterone subcutaneously (SubQ), a shallow injection into the fat layer on the abdominal or other areas—just under the skin but before reaching muscle. Many TRT patients find SubQ injections less bothersome than IM injections, as they require a smaller needle in both length and gauge. SubQ injections are also associated with less irritation for some men with IM injections. While some men may find IM injections to leave a minor soreness at the injected site, SubQ injections cause no noticeable pain or irritation. Understanding Testosterone Replacement Therapy Testosterone Replacement Therapy (TRT) is a medical treatment designed to help individuals with low testosterone levels, also known as hypogonadism. TRT aims to restore normal testosterone levels, alleviating symptoms such as low libido, fatigue, and decreased muscle mass. This form of hormone therapy can significantly improve the quality of life for those experiencing sexual dysfunction and other related issues. TRT can be administered through various methods, including intramuscular injections, subcutaneous injections, and topical gels. In this article, we will focus on testosterone injections, specifically intramuscular and subcutaneous injections, to provide a comprehensive understanding of these methods. Testosterone Injection Methods: Effects on Total Testosterone, Estradiol (E2), and PSA Testosterone Cypionate and Testosterone Enanthate are the two most commonly used forms of testosterone in men to treat hypogonadism (low testosterone). Both forms carry the same testosterone hormone; the ester is the only difference, which alters the hormone’s time release so that testosterone blood levels can remain up for a few days. These two testosterone compounds are identical in a testosterone replacement therapy (TRT) setting. Both forms are commonly used in hormone replacement therapy to treat hypogonadism in men. Where and How to Inject Testosterone? Regardless of which TRT product you’ve been prescribed, a common question is where to inject testosterone. For decades, most men have injected their testosterone intramuscularly (IM), primarily into the glutes, quads, or deltoids, using a 1- to 1.5-inch syringe. During the past five years, many men have also begun injecting testosterone subcutaneously (SubQ), a shallow injection into the fat layer on the abdominal or other areas—just under the skin but before reaching muscle. Many TRT patients find SubQ injections less bothersome than IM injections, as they require a smaller needle in both length and gauge. SubQ injections are also associated with less irritation for some men with IM injections. While some men may find IM injections to leave a minor soreness at the injected site, SubQ injections cause no noticeable pain or irritation. Many patients find it beneficial to inject weekly to maintain stable testosterone levels. Administering Testosterone Injections Safely Administering testosterone injections safely requires proper technique and precautions to ensure effectiveness and minimize risks. Before injecting, ensure the injection site is clean and free of any debris. Use a sterile needle and syringe, and follow the recommended dosage and injection frequency as prescribed by your healthcare provider. For intramuscular injections, use a longer needle (1 to 1.5 inches) and insert it at a 90-degree angle into the muscle, typically in the glutes, quads, or deltoids. For subcutaneous injections, use a shorter needle (0.5 to 1 inch) and insert it at a 45-degree angle into the fatty tissue, commonly in the abdominal area. Always dispose of used needles and syringes properly to prevent injury and contamination. By following these steps, you can administer testosterone injections safely and effectively. Choosing the Right Injection Site Choosing the right injection site is crucial for safe and effective testosterone injections. For intramuscular injections, common sites include the buttocks, thigh, and upper arm. These areas have larger muscle masses, which are ideal for proper absorption of the hormone. For subcutaneous injections, common sites include the abdomen, thigh, and buttock. When selecting an injection site, consider the following factors: Fat layer: Subcutaneous injections require a sufficient fat layer to ensure proper absorption. Muscle mass: Intramuscular injections require a larger muscle mass to ensure proper absorption. Nerve proximity: Avoid injecting near nerves to minimize the risk of nerve damage. Scarring: Rotate injection sites to minimize scarring and promote even absorption. By carefully choosing the injection site and rotating locations, you can enhance the effectiveness of your testosterone injections and reduce potential complications. What is the Best Way to Inject Testosterone? While subcutaneous testosterone injections are by far the most uncomplicated and most comfortable, the more critical question for any TRT patient is how effective this method is and how it affects the potential adverse side effects of TRT. Weekly injections are often recommended to maintain stable hormone levels and reduce side effects. A recent study from the Department of Urology at the University of California (UC) has provided us with such answers. The UC study attempted to answer four questions as they relate to IM vs. SubQ testosterone injections: Comparisons in: Total Testosterone Hematocrit (HCT) Estradiol (E2) Prostate-Specific Antigen (PSA) Two hundred thirty-two men took part in the UC study. Baseline levels were recorded for all men in the four measurement areas and then again at 6-12 weeks post-treatment. The results showed that men who underwent SubQ injections of testosterone resulted in a 14% greater increase in total testosterone levels than the testosterone level of IM patients. SubQ patients also had 41% lower hematocrit post-therapy than IM patients and 26.5% lower E2 levels. For both groups of men, there were no elevated levels of PSA. Additional Studies Comparing IM versus SubQ TRT While the UC study provides valuable data on four specific lab test values of concern and is one of the most recent studies on the topic of subcutaneous versus intramuscular testosterone injections, it is not the only information we have available. An additional Journal of Clinical Endocrinology study found that normal serum testosterone levels were maintained through SubQ injections. Most patients preferred the injection method due to less injection site pain. Similar results were found in a study headed by Dr. Al-Futais in a Canadian study that ran for one year in 2002. Similar results for subcutaneous testosterone injections have also been found in female-to-male (FTM) transgender people-based testosterone studies. The Journal of Clinical Endocrinology and Metabolism reported that FTM patients administering SubQ testosterone were found to easily reach stable and normal testosterone levels along with suitable E2 levels. The study concluded that SubQ testosterone injections are both safe and effective. These findings are particularly relevant for those undergoing gender-affirming hormone therapy, as they highlight the effectiveness and patient preference for SubQ injections. Although far less in-depth than we previously mentioned, a final study of note was published in the Journal of the Endocrine Society. Similar results to the reviews mentioned above were found, along with no significant changes between IM and SubQ patients relating to dihydrotestosterone (DHT). Interestingly, unlike the UC study, this study also measured no notable difference in E2 levels between the two categories. However, it must be noted that this particular study only included a single injection of testosterone undecanoate at 1000 mg. How to Inject Testosterone Using Subcutaneous Injections? If subcutaneous testosterone injections are right for you, you will merely need a small insulin syringe to administer the hormone. A 0.5-inch-long, 25-27 gauge needle in a 1 ml syringe will typically suffice. They also do not require aspiration, commonly used in old IM injection techniques. Unlike IM testosterone injections, SubQ injections do not require aspiration and use a smaller needle. Regardless, the aforementioned insulin needles and syringes are your best choice for comfort and ease of use. Due to the small needle size, you may find it slightly more difficult to draw the testosterone into the insulin syringe. But most men on TRT use 50-100 mg twice per week, which amounts to 0.25 to 0.5 ml of a 200 mg/ml testosterone cypionate or enanthate formulation commonly used in the United States. Those small volumes load up in just 1-2 minutes. Many TRT clinics prescribe protocols to patients to inject their testosterone subcutaneously once or twice weekly. This protocol effectively maintains stable testosterone levels with small, more frequent doses than the old dose of 200 mg once every two weeks. Two injections that split the weekly dose twice per week will suffice for most patients, such as a Monday and Thursday protocol. Is There Any Difference Between Testosterone Cypionate and Testosterone Enanthate? As mentioned early on, testosterone cypionate and testosterone enanthate are the two most commonly prescribed and lowest-cost testosterone esters worldwide. All four studies cited in our discussion were performed using Testosterone Enanthate, excluding the one using Undecanoate. However, using Testosterone Cypionate would have yielded similar, if not identical, results. Both versions of the testosterone hormone are just that, testosterone. Molecularly, there is no difference. It is merely the ester attached, and the carrier oil it may be mixed in is the only difference. Further, as the enanthate and cypionate esters have very similar time-release structures, total serum levels should be relatively the same with either compound, even if injected subcutaneously. Conclusion In conclusion, testosterone replacement therapy is a medical treatment designed to help individuals with low testosterone levels. Administering testosterone injections safely requires proper technique and precautions. Choosing the right injection site is crucial for safe and effective testosterone injections. By understanding the differences between intramuscular and subcutaneous injections, individuals can make informed decisions about their treatment options. Always consult with a healthcare professional before starting testosterone replacement therapy to ensure the best approach for your specific needs. References How to Inject Testosterone Intramuscularly, Shallow IM, or Subcutaneously? Comparison of Outcomes for Hypogonadal Men Treated with Intramuscular Testosterone Cypionate versus Subcutaneous Testosterone Enanthate SIU Academy. Choi E. 10/10/20; 309864; BSP-06.01 Subcutaneous Injection of Testosterone Is an Effective and Preferred Alternative to Intramuscular Injection: Demonstration in Female-to-Male Transgender Patients  The Journal of Clinical Endocrinology & Metabolism, Volume 102, Issue 7, 1 July 2017, Pages 2349–2355 Pharmacokinetics and Acceptability of Subcutaneous Injection of Testosterone Undecanoate J Endocr Soc. 2019 Aug 1; 3(8): 1531–1540.

Testosterone is typically thought of as a hormone for men. Still, it is also essential for women as it influences sexual functioning, mood, the development of lean muscle mass, and even memory and cognition. Women who are in their 40s have about half the level of testosterone that was present in their 20s. We see a significant decline in testosterone levels over time. Women with low or suboptimal testosterone levels can experience many symptoms, including sexual dysfunction and a decrease in sexual drive or desire, known as low sex drive (hypogonadism). They can also notice that they have increased fatigue. They're tired. Also, it's more challenging to develop lean muscle mass. It can have a significant impact even on mood, an overall sense of well-being, motivation, a feeling of confidence, and assertiveness. Also, it can affect memory and cognitive function. A low libido: As testosterone helps fuel a healthy sex drive, a decline in sexual interest or inability to achieve orgasm may be a symptom of lower testosterone levels in both sexes. A study published in the journal of the American Medical Association showed that approximately 43% of postmenopausal women suffer from some form of sexual dysfunction. Surprisingly, we don't hear a lot about this condition in women. We certainly don't hear about options for treatment, including testosterone. This condition can often go undiagnosed and undertreated. NO FDA-APPROVED TREATMENTS FOR LOW TESTOSTERONE ON WOMEN Currently, there is no FDA-approved testosterone replacement therapy for women, even though providers have been prescribing it in an off-label manner, which is when a medication is prescribed for something other than its official FDA-approved indication. Providers have been doing this for over 50 years now. Testosterone can be replaced in various forms. It can be given in a shallow-dose injection once a week. It can also be given sublingually in a troche form, which dissolves in the mouth. Also, it can be administered through a minor surgical procedure. It's known as subcutaneous pellet insertion. And then it can also be given in topical form as a cream or a gel. The most common form of replacement we see is topical gel or cream, which can be supplied by compounding pharmacies. The benefit of doing it this way is that the provider can adjust the dose based on the individual patient's needs and response to therapy. It's more than just one standard dose, and it better work for you, or there's no other option.  Testosterone creams can be customized for the needs of the individual patient. When you replace any hormone in this manner at low daily doses, it is very similar to the way the body naturally produces hormones. After starting testosterone replacement therapy, women typically notice a significant improvement in all symptoms, including increased sexual functioning, desire, and drive. They can also see an increase in energy levels and an increased ability to develop lean muscle mass. Additionally, they can notice a significant improvement in mood, motivation, overall sense of well-being, and confidence. In addition, they may see improved memory and cognitive functioning. Another critical point is that when testosterone is given to a woman, a portion of it will convert to estrogen. The postmenopausal woman with low estrogen levels can see improvement in those symptoms typically associated with low estrogens, such as hot flashes, night sweats, moodiness, irritability, and vaginal dryness. So, women may experience improvements in the classic symptoms of low testosterone and the typical menopausal symptoms associated with low estrogen. Several studies support the use of hormone replacement therapy, specifically testosterone replacement therapy, in women. A Cochrane review of the literature found that over 35 trials have been performed, which included over 4500 women. They found a significant improvement in sexual functioning in women on hormone replacement therapy. Also, a more recent study published in 2014 showed that women on a transdermal or topical form of hormone replacement therapy had an improvement in memory and cognitive functioning. Several studies support the use of this vital hormone in women. POTENTIAL SIDE EFFECTS OF TESTOSTERONE IN WOMEN In terms of safety, there are potential side effects with the use of any medication. In testosterone therapy, if doses are too high, women can notice adverse effects, such as acne and an increase in hair growth, known as hirsutism. Also, with extremely high doses, they may see a deepened voice or enlargement of the labia or clitoris. That would typically be something that's dose-dependent. If a physician was a little bit aggressive with their starting dose, they might notice some side effects of testosterone treatment, such as disturbed breathing while sleeping, breast swelling or tenderness, swelling in the ankles, or too much testosterone. Doctors also watch out for high red blood cell counts, which could increase the risk of clotting. By decreasing and backing off on the dosage, those symptoms will resolve. One important fact to mention for premenopausal women who are still menstruating is that providers need to discuss the use of birth control with them because testosterone is considered category X, meaning it will cause fetal harm if a woman becomes pregnant while she's on testosterone replacement. That's just a discussion that the patient needs to have with their provider, “What is your reliable form of birth control?" before prescribing it to them. Testosterone replacement therapy is very safe for premenopausal women on birth control and postmenopausal women. It has a low risk of side effects when used at appropriate doses, and many studies support its use in this population. SEXUAL DYSFUNCTION AND LOW TESTOSTERONE IN WOMEN We are all aware that if we watch TV for more than an hour each day, we will constantly see advertisements for medications to treat erectile dysfunction in men. But we hardly hear anything about sexual dysfunction in women. There are many reasons why women’s sexual desire and other hormone-related quality-of-life issues are so misunderstood, underdiagnosed, and undertreated. Sexual dysfunction in pre and post-menopausal women has been a very controversial topic that has been poorly researched, even though a February 1999 study published in the Journal of the American Medical Association, titled “Sexual Dysfunction in the United States: Prevalence and Predictors,” found that approximately 43% of postmenopausal women suffer from some form of female sexual dysfunction. It wasn’t until June 2011 that an FDA advisory committee to the division of Reproductive and Urologic Drug Products stated that HSDD (Hypoactive Sexual Desire Syndrome) is a significant medical condition for women. This may open the door for companies to apply for new drug applications for that indication. It is important to note that unlike erectile dysfunction drugs approved for men, like Viagra, which increase blood flow to the genitals as long as a man is aroused, testosterone therapy is systemic and needs to be applied over weeks to have a noticeable effect on sex drive in men and women. Some companies have tried to enter the female sexual dysfunction market in the past. In December 2004, the United States FDA rejected Procter & Gamble's fast-track request for Intrinsa (a testosterone patch for women) for HSDD, citing concerns about potential off-label use of the product. In Canada, post-menopausal women have been able to obtain government-approved testosterone treatment since 2002. In 2007, Intrinsa was granted a license from the European Medicines Agency in July and was available on Britain's National Health Service. According to P&G's survey on female health, 30 million women in the U.S. are naturally menopausal, 3 million are distressed by their lack of sexual desire, and 20% of 25 million surgically menopausal women are distressed. Other companies that attempted to get their drugs approved for this indication (Boehringer Ingelheim and Warner Chilcott) have pulled the plug on their competing HSDD treatments for menopausal and pre-menopausal women. BioSante Pharmaceuticals also got their testosterone gel for women, LibiGel, rejected by the FDA. HORMONE THERAPY IN POSTMENOPAUSAL WOMEN Menopause can cause symptoms such as hot flashes that might result from the changing hormone levels during the menopause transition. After a woman's last menstrual period, when her ovaries make much less estrogen and progesterone, some symptoms of menopause might disappear, but others may continue. To help relieve these symptoms, some women use hormones. This is called hormone therapy (HT), which includes estrogen alone or in combination with progesterone. HT is available orally or in gel formulations made by specialized compounding pharmacies. Estrogen is a hormone used to relieve the symptoms of menopause. A woman who had her uterus removed could use only estrogen (E). But a woman with a uterus must add progesterone, or progestin (synthetic progesterone), and estrogen (E+P). This combination lowers the chance of an unwanted thickening of the uterus lining and reduces the risk of cancer of the uterus, an uncommon but possible result of using estrogen alone. CONTROVERSIES IN HORMONE TREATMENTS FOR WOMEN But the use of hormone therapy in women has been subject to much controversy in the recent past. The Women's Health Initiative (WHI) was a landmark clinical trial that looked at the effects of combination hormone therapy (estrogen + progestin) in 16,608 postmenopausal women with an intact uterus. The women were aged 50 to 79 (average age of 63) when they joined the study. This study did not include the use of testosterone. In this study, 8,506 participants were randomly assigned to receive a combination of estrogen (0.625 milligrams of conjugated equine estrogens per day) plus progestin (2.5 mg of medroxyprogesterone acetate), and 8,102 women were given a placebo.  The study was stopped in 2002 after an average of 5.6 years of treatment due to increased breast cancer in women on hormone therapy. Compared to women on placebo, women on combination hormone therapy were also at increased risk of stroke, dangerous blood clots, and heart disease. In contrast, their risk of colorectal cancer and hip fractures was lower. It is important to note that these hormones were provided orally, and some clinicians claim that transdermal (on the skin) application of estrogen alone or in combination with testosterone would show a different and more favorable side effect profile. The halting of the WHI study raised concerns about the safety of all hormone therapy in women (oral or transdermal), even if no androgens were included in this study and only oral delivery forms were used. Many physicians stopped prescribing hormone therapy (HT) even for women who had dramatic improvements in their quality of life while using it. Experts today don't recommend hormone therapy unless a woman suffers painful menopause symptoms. New information about the use of androgens (testosterone and DHEA) alone or with HT suggests that these hormones may help women who do not have enough androgens and have problems with their sexual health. Androgens are also precursors of all estrogens (estrone (E1), estradiol (E2), and estriol (E3)) in women's bodies. The primary and most well-known androgen is testosterone (which aromatizes into estradiol); other less essential androgens are dihydrotestosterone (DHEA) and androstenedione. The ovaries and adrenals directly secrete androgens in women. Presently, there is no agreement about whether androgen deficiency is a clinical problem in aging women and if the addition of androgens to HT can improve the cardiovascular risks seen in the WHI study. Causes of androgen insufficiency in women can have ovarian, adrenal, hypothalamic-pituitary, drug-related, and unknown origins. Symptoms of adrenal insufficiency and androgen insufficiency in women may include a diminished sense of well-being, low mood, fatigue, and hypoactive sexual desire disorder (HSDD) with decreased libido or reduced sexual receptivity and pleasure that causes a great deal of personal distress. Premature ovarian insufficiency (POI) is another possible cause of androgen insufficiency in women. POI occurs when the ovaries stop functioning normally before 40 years of age. Although menopause is the most common cause of ovarian failure, other factors, such as chemotherapy or radiation therapy, can also contribute to POI. Therefore, it is important to consider premature ovarian insufficiency as a potential cause of androgen insufficiency in women. There is increasing evidence to suggest that many postmenopausal women experience symptoms alleviated by androgen therapy and that such symptoms may be caused by androgen deficiency. Affected women complain of fatigue, low libido, and diminished well-being, which are symptoms easily and frequently attributed to psychosocial and environmental factors. The question of whether adding testosterone therapy to conventional postmenopausal HT is effective or safe is unresolved. Therefore, a Cochrane review was performed to determine the efficacy and safety of testosterone therapy for postmenopausal women using HT. Thirty-five trials with a total of 4768 participants were included in the review. The median study duration was six months (range: 1.5 to 24 months). Most of the trials were of adequate quality regarding randomization. The pooled estimate suggested that adding testosterone to HT regimens improved sexual function scores and the number of satisfying sexual episodes for postmenopausal women. Some of the few adverse effects were decreased high-density lipoprotein (HDL) cholesterol levels and increased hair growth and acne incidence. The discontinuation rate was not significantly higher with the addition of testosterone therapy. OTHER USES FOR TESTOSTERONE IN WOMEN Emerging and controversial potential indications for androgen therapy in women have been or are being evaluated. Women with early ovarian failure, premenopausal androgen deficiency symptoms, postmenopausal and glucocorticosteroid-related bone loss, HIV-related wasting, and the premenstrual syndrome can all use this medicine. Whether or not any of these indications will lead to approved products in the future is unknown. HOW TO MEASURE LOW TESTOSTERONE IN WOMEN The term hypogonadism is used as a diagnostic term for testosterone deficiency, also known as testosterone insufficiency, in men. Besides HSDD as one of the potential symptoms, there is no agreement on what to call androgen deficiency in women. Clinical guidelines published in 2002 called the Princeton Consensus Statement used the term "female androgen insufficiency" as defined as a pattern of clinical symptoms in the presence of decreased bioavailable testosterone and normal estrogen status. The panel warned that currently available testosterone assays were found to lack sensitivity and reliability at the lower testosterone blood level ranges in women. The need for an equilibrium dialysis measure was strongly emphasized as the most adequate method to test women’s testosterone blood levels. BUY THE MOST AFFORDABLE AND ACCURATE TESTOSTERONE TEST FOR WOMEN Women in the United States can buy a testosterone test for women online without needing a doctor's prescription by using DiscountedLabs.com. They can also obtain a complete blood test panel to measure other hormones like estrogen, DHEA, progesterone, and testosterone. HOW TO TREAT LOW TESTOSTERONE IN FEMALES Circulating testosterone in women declines during the late reproductive years, such that otherwise healthy women in their 40s have approximately half the testosterone level as women in their 20s. The levels remain stable across the menopausal transition and then either remain stable or continue to decline with diminishing adrenal androgen production with increasing age. In the decade preceding menopause, the mid-cycle surge of free testosterone is lost. Despite this, research showing the benefits of androgen replacement has been limited to postmenopausal years. This means that testosterone levels in women change throughout the month based on one's menstrual cycle. However, the mid-cycle surge of free testosterone is lost in the decade preceding menopause. Some small studies have been done in premenopausal women, however. One evaluated the efficacy of transdermal testosterone therapy on mood, well-being, and sexual function in premenopausal women with low libido in eugonadal (normal testosterone blood levels). Testosterone therapy improved the well-being, mood, and sexual function of these women. Since many women experience diminished sexual interest and welfare during their late reproductive years, further research is warranted to evaluate the benefits and safety of the longer-term intervention. Potential dose-dependent side effects may be unwanted hair growth, masculinization, and high-density lipoprotein (HDL) lowering. TESTOSTERONE REPLACEMENT AND CARDIOVASCULAR RISKS IN WOMEN A direct association between testosterone and heart disease has never been established, but doctors have suspected a link exists for many years. The reasoning goes like this: men have much more testosterone than women and develop heart disease about ten years before their female counterparts. On top of standard medical therapy, women with systolic heart failure who took low-dose testosterone for six months showed significant gains in exercise and ventilatory capacity and large-muscle strength, along with heightened insulin sensitivity, in a small placebo-controlled trial . Despite the entrenched belief that higher blood levels of testosterone increase the risk of CVD in women, data from recent observational studies mostly show an inverse relationship between testosterone and CVD risk. A pilot study (JCEM 86 (1): 158) suggested favorable effects of transdermal testosterone treatment of women with established congestive cardiac failure, which merits further evaluation. Some early research shows that giving postmenopausal women testosterone therapy through injections improves both flow-mediated and GTN-mediated vasodilation in the brachial artery. The mechanisms underlying these potentially beneficial cardiovascular effects require further investigation. TESTOSTERONE REPLACEMENT AND CANCER IN WOMEN The relationship between endogenous testosterone production and breast cancer risk remains contentious, with recent studies indicating either no relationship or a possible increase in risk when estrone and estradiol are not considered. No randomized controlled trial of testosterone therapy has been sufficiently large or of sufficient duration to establish whether such treatment may influence breast cancer occurrence. There does not appear to be an association between testosterone and endometrial cancer or other malignancies in the review of published studies. There is no convincing evidence that standard estrogen-based hormone therapy for ovarian failure increases the risk of breast cancer. However, some studies have previously shown that ovarian androgens protect mammary epithelial cells from excessive estrogenic stimulation. Therefore, a study hypothesized that adding testosterone to usual hormone therapy might protect women from breast cancer. This retrospective observational study followed 508 postmenopausal women receiving testosterone and standard hormone therapy in South Australia. Breast cancer status was ascertained by mammography at the initiation of testosterone treatment and biannually after that. The average age at the start of follow-up was 56.4 years, and the mean duration of follow-up was 5.8 years. Breast cancer incidence in this group was compared with that of untreated women and women using usual hormone therapy reported in the medical literature and to age-specific local population rates. There were seven cases of invasive breast cancer in this population of testosterone users, for an incidence of 238 per 100,000 woman-years. The rate for estrogen/progestin and testosterone users was 293 per 100,000 woman-years—substantially less than women receiving estrogen/progestin in the Women's Health Initiative study (380 per 100,000 woman-years) or the Million Women Study (521 per 100,000 woman-years). The breast cancer rate in testosterone users in this study was closest to that reported for users who never used hormone therapy in the latter study (283 per 100,000 woman-years), and their age-standardized rate was the same as for the general population in South Australia. Based on these findings, adding testosterone to traditional hormone therapy for postmenopausal women may not raise the risk of breast cancer and may even lower it, bringing the rates back to what they are in the general population that is not on hormone therapy. But more studies are needed. LATEST DATA ON TESTOSTERONE AND WOMEN: A recent study review by Dr. Rakibul Islam and his team was published in The Lancet in July 2019 and retrieved 46 reports of 36 randomized controlled trials comprising 8480 female participants. Their meta-analysis showed that testosterone significantly improved sexual function compared to a placebo or a comparator (e.g., estrogen with or without progesterone). It improved sexual desire, pleasure, arousal, responsiveness, and self-image, and it decreased sexual concerns and distress in postmenopausal women. A significant rise in the amount of LDL-cholesterol and reductions in total cholesterol, HDL-cholesterol, and triglycerides were seen with testosterone administered orally but not when administered non-orally (e.g., by transdermal patch or cream). An overall increase in weight was recorded with testosterone treatment. No effects of testosterone were reported for body composition, musculoskeletal variables, or cognitive measures, although the number of women who contributed data for these outcomes was small. Testosterone was associated with a significantly greater likelihood of reporting acne and hair growth, but no serious adverse events were recorded. TESTOSTERONE USE IN WOMEN IN THE UNITED STATES As previously mentioned, there is no FDA-approved testosterone product for women. Some doctors prescribe drugs for female patients by having them use low doses of products like Androgen, Testim, Axiron, Testopel, and Fortesta that are meant for male hypogonadism without following the product's label. Other doctors prescribe creams with low testosterone levels through compounding pharmacies. However, it is important to note that women and people with AFIB require significantly less testosterone, necessitating a much lower dose of medication compared to men. CONCLUSION In conclusion, low testosterone in women is a condition that is often overlooked and underdiagnosed. However, it can have significant impacts on a woman's quality of life, including decreased sex drive, fatigue, and mood changes. Fortunately, there are several treatment options available, including hormone replacement therapy, lifestyle changes, and medication. It is important for women to speak with their healthcare provider and get properly diagnosed and treated for low testosterone if necessary. By doing so, they can improve their overall health and well-being.   References: Effects of testosterone therapy for women: a systematic review and meta-analysis protocol.Syst Rev. 2019; 8: 19   Efficacy and safety of transdermal testosterone in postmenopausal women with hypoactive sexual desire disorder: a systematic review and meta-analysis. Fertil Steril. 2017; 107: 475-482

Searching for " TRT Doctor Near Me "? If you have signs of low testosterone, like low sex drive, erectile dysfunction, less motivation, or mood swings, you should find a good TRT doctor near you. A qualified TRT doctor can treat these issues with testosterone replacement therapy. This treatment can help boost your sex drive and sexual function. It can also raise your energy levels and improve your mood and thinking. With a TRT doctor by your side, you can feel like yourself again and enjoy life better. Plus, having low testosterone levels might put you at a higher risk for heart disease. That’s why it’s important to see a trusted TRT doctor. Understanding Testosterone Replacement Therapy (TRT) Testosterone Replacement Therapy (TRT) can change lives for men with low testosterone levels. This treatment helps those who want a better life. TRT means using testosterone medications to bring testosterone levels back to a normal state in the body. It can boost mood and energy levels, improve libido, and increase muscle mass. It may also reduce body fat and irritability. However, you should talk to a qualified TRT doctor before starting. The doctor will check your testosterone levels and explain the risks and benefits of this therapy. They will help you decide if it is right for you. What is Low Testosterone or Hypogonadism? Low testosterone, also known as hypogonadism, affects many men as they get older. Testosterone levels are highest during early adulthood. After 30, these levels usually drop by about 1 to 2 percent each year. This slow decline can cause several health problems. A low testosterone level can result in symptoms that can greatly affect a man's life. It is important to understand what low testosterone means. This can help in knowing when to seek medical checks and possible treatment. As testosterone levels drop, men might feel several symptoms. These include tiredness, lower libido, and mood swings. These changes can link to a condition called hypogonadism. This condition can impact sexual health and may need medical help to balance hormones again. If you think you have low testosterone, it's important to talk to a qualified doctor. They can provide the right diagnosis and treatment options for you. Common Symptoms of Low-T Recognizing the signs of low testosterone is important for quick diagnosis and treatment. Many men with low testosterone, or Low-T, face several concerning symptoms that can impact their everyday life. Here are some common symptoms to watch for to get more info: Reduced sex drive: A drop in libido can cause problems in relationships and lower overall happiness. Erectile dysfunction: Low testosterone levels can make it hard to get or keep an erection, which affects sexual performance. Loss of muscle mass: Many guys see a reduction in strength and muscle tone, making it tough to stay fit. Fatigue: Ongoing tiredness and low energy are common issues linked to low testosterone levels. It is important to know that these symptoms can feel different from person to person. Many things, like age, lifestyle, and health, can change how severe they are. If you notice any of these symptoms, especially those related to prostate health, it's a good idea to see a doctor. A healthcare professional can do tests to check your testosterone levels. They can also talk about the right treatment options for you. Understanding and dealing with low testosterone can really help improve your health and well-being. Your Ultimate Guide to Finding a TRT Doctor Near Me When we start any health treatment, we mainly want to find the best options. This is true for men who feel symptoms of low testosterone. Sadly, many men find it very hard to find a doctor who will treat testosterone deficiency properly. More doctors around the world are learning about testosterone and how to treat it. Still, some doctors think treating low testosterone is unnecessary. They believe testosterone levels drop naturally as we age, so we should just accept it. This view is strange because doctors usually don’t think this way about other health issues. For many years, testosterone and related supplements have been viewed differently in medicine for several reasons we won't discuss now. Right now, we just want to understand how to find the right testosterone replacement therapy (TRT) doctor. A good doctor can help meet your needs and boost your quality of life as you age. Plus, you can still enjoy a satisfying sexual life. When you search for "testosterone doctor near me" on Google, you will see many clinics advertised. But how do you find the best one for you? It might surprise you that there are no reliable doctor directories for testosterone and hormone treatments, not just in the United States but worldwide. Thankfully, a new directory helps men and women find hormone clinics nearby. Just go to the site and click on "Search." If there are clinics near you, they will email you with details about their services, including hormone replacement therapy. You can also tailor your search by health issues, TRT, and other related products that interest you. To find a TRT doctor near you, click on the image below. Main Questions to Ask a TRT Doctor Once you find a doctor who treats low testosterone with TRT therapy, this is just the first step. The next step is more important and can be harder. You need to find a doctor who prescribes TRT the right way. There are many ways to treat low testosterone, just like the saying goes about skinning a cat. But, some of these ways can be less effective and could even cause problems or worse outcomes. First, learn as much as you can by reading a testosterone book such as "Testosterone: A Man's Guide." Also, check posts on the top TRT forum, ExcelMale.com. This knowledge will help you become an informed patient. You will feel more comfortable asking questions to a TRT doctor or clinic. Once you find a doctor who treats TRT, there are several questions to ask. Some doctors may not want to answer these questions. They might feel you are questioning their skills and prefer you to stay quiet and accept what they say without asking. It's important to remember that while you should respect your doctor, they are here to serve you. You pay for their services. If a doctor is not willing to answer basic questions or have a discussion, it may be time to look for another one. If your TRT doctor is open to talking before taking the next steps, here is a helpful list of questions for you to ask: 1. How long have they been treating patients with low testosterone, and how many are they currently treating? The answer to these two questions does not have to be a deal-breaker. This is true if a person hasn't been doing this for long or if they haven't treated many people. What really matters is that they know the right way to treat. Still, if the numbers are low, this might be a sign to watch. Anyway, let’s keep going with our questions. 2. What type of TRT treatment options do you prescribe—injectables, creams, or other options? Self-given injectable testosterone is often seen as one of the best and most affordable ways to handle low testosterone. However, some men might feel uneasy about using needles. For them, testosterone gels or creams could help with weight loss. Other options for testosterone replacement therapy (TRT) include pellets, nasal gel, oral forms, long-lasting injections, and more. 3. Do they accept insurance or cash pay only? If they take insurance, that's great. You should use it with good treatment. But if you can only get the best treatment by paying cash, you may need to choose that option if your budget lets you. 4. Do they prescribe HCG along with testosterone, or have it available as an option for treating testicular atrophy or helping to preserve fertility? Many men like the extra benefits that HCG can provide for their testosterone replacement therapy (TRT). Younger patients especially feel good knowing that they can still conceive well with HCG. Sadly, many doctors, even those who know more about testosterone than most, do not get the advantages of using HCG with TRT. This can be a warning sign, and it might be a good idea to find a new doctor. 5. Do they prescribe other products or ED medications? When a person is on testosterone replacement therapy, simply boosting testosterone levels is not enough. We need to think about all the hormones in our body. One important hormone to watch is estradiol. A high level of estradiol compared to testosterone can cause unwanted side effects. These may include gynecomastia, water retention, and erectile issues. For instance, if a man has too much estrogen, he may struggle to get a firm erection. On the other hand, if he has too little estrogen, keeping an erection can be hard. Testosterone is also key for strong bones and muscle mass. Contrary to what people read online, most men won't need an aromatase inhibitor in the long run. However, having the option to get one when necessary is important. Moreover, when a man has low testosterone and sees symptoms like gynecomastia or growing breasts, gaining weight can lead to further health issues, such as high cholesterol and diabetes. 6. Blood testing: How often is your doctor going to run lab tests? What are they going to check on the lab report? After the first test, you should have lab tests every 6 to 8 weeks. This should continue until your levels are stable and in a good range. It may take 3 to 6 months to achieve this. A “good range” means looking at both your numbers and how you feel. Be sure to ask your doctor if they will check both total and free testosterone in your tests. Just checking total testosterone is not enough. Also, ask your doctor if they'll check estradiol levels with the sensitive estradiol test, not the regular estrogen test. Remember, the sensitive estradiol test may not be available in all countries. A regular test often shows higher estradiol levels due to other factors affecting the results. Many people still discuss if it’s necessary to manage or treat high estrogen levels in men who are on TRT. Your doctor should check your hemoglobin and red blood cell levels. They can request a therapeutic phlebotomy at the nearest blood center. This will allow you to donate blood. Some doctors may check your thyroid function. This is because low thyroid (hypothyroidism) can feel similar to low testosterone. So, make sure to mention it! Remember, if your doctor is open and caring, they might let you order your own lab tests. This way, you can get the exact tests you need through sites like DiscountedLabs.com. 7. Do they offer prescriptions for therapeutic phlebotomy for high hematocrit? Your blood might get a bit thick with TRT. This is not a big problem if we fix it, and it's simple to correct. You can go to a blood center and donate blood. If your doctor orders the right tests, you can keep an eye on this issue. If needed, you can solve it by donating blood. Remember that giving blood often can lower your iron and ferritin levels. This can lead to feeling very tired. Do not donate blood more than once every 2.5 months. 8. Do they offer other treatment options, such as erectile dysfunction medications, high blood pressure medications, or other wellness options? You might need these things or you might not; we will see as time goes by. However, it's always a good idea to have them available just in case you need them. 9. One of our most important questions we will need to ask our doctor is: do they allow self-injecting at home? If the testosterone injection plan is done right, we will discuss it in the next question. There is nothing more frustrating than visiting the doctor every week or even several times a week. Your doctor should let you inject the medicine at home. If they do not, it's time to find a new doctor. 10. Injection protocols: Ask your doctor if they are prescribing testosterone cypionate or testosterone enanthate and what their typical injection protocols look like. If your doctor gives you injections every two weeks or less, ask if you can take them once a week or even twice a week. Some men feel the effects of testosterone replacement therapy (TRT) wearing off around days 12 to 14 with just every two-week injections. Also, if your doctor does not let you use an insulin syringe to inject under the skin instead of older methods, ask why. New information shows that subcutaneous injections work just as well as deep intramuscular ones and are less painful. 11. Does your TRT doctor work with compounding pharmacies or allow you to work with the pharmacy of your choice? If your insurance covers your TRT, be sure to compare pharmacies. Look for one that offers the lowest copay. If you are paying in cash, check compounding pharmacies. They often have lower prices for injectable and transdermal (gel or cream) testosterone products. A good doctor will give you a prescription for a generic drug. This helps you go to a compounding pharmacy. There, you can get the same testosterone for a much lower price than with a big-brand pharmacy. A good doctor likely knows someone at a compounding pharmacy, which makes this process easier. Plus, you will usually find that the service at a compounding pharmacy is better than at other pharmacies you know. 12. Ask your doctor how many times they will require you to come to the office. If it’s more than twice a year, this doctor probably isn’t for you. It is important for you to know that the doctor will let you see your lab results. They should also have an open talk with you about your health. If you feel that this will not happen, you should consider finding another doctor. 13. What’s all this going to cost me? How much will the doctor’s visit cost, including any follow-up visits? How much will blood work cost, including follow-up labs? Finally, how much can I expect to pay monthly for medications, and are there any other fees I need to be aware of that may exist? Preparing for your first TRT doctor visit is important. It helps you feel confident in your decision. It also helps you understand what to expect and how much it will cost. Visit ExcelMale.com for information about TRT treatment options and other men's health choices. Common Men’s Tests: Bodybuilder Tests Cancer Tests Erectile Dysfunction Tests Fatigue Tests Hormone Clinic Referrals Hormone Testing Hormone Tests for Men Male Hormone Tests Men's Health Tests Testosterone Tests Thyroid Lab Tests TRT Side Effects Tests TRT Tests These tests can help you understand your health better. There are options for issues like erectile dysfunction. You can also look into testosterone tests. They can provide useful information for men's health.   Common Questions   How Can I Get Prescribed TRT Near Me? If you think you might have low testosterone levels and want to look into TRT as a treatment, you should talk to a healthcare professional. A primary care doctor or an endocrinologist at a men's health clinic can help you. They will check your symptoms and look at your medical history. They may also do blood tests to check your hormone levels. If these tests show low testosterone levels and you qualify for TRT, your provider can explain the benefits and risks of this therapy. They will also help you get a prescription if needed. It is very important to work with a qualified healthcare professional. This will help you get the right diagnosis. They will also monitor and manage any hormonal imbalances properly. What is the cost of TRT? Every clinic charges different prices for lab work, medications, and doctor visits. A self-pay clinic can cost between $100 and $250 each month. This depends on the TRT and other medications that are given. Does insurance typically cover TRT? TRT, or Testosterone Replacement Therapy, may or may not be paid for by insurance. This depends on your insurance plan and your testosterone level. Some insurance plans can cover TRT, especially if it is needed for low testosterone levels. However, the coverage can be very different from one plan to another. So, it is important to ask your insurance provider if TRT is included in your plan. You may also need to meet some requirements or get approval from your insurance company before you start TRT. It is smart to talk with your healthcare provider and your insurance company to understand the details of your coverage for TRT. What type of doctor should I see for TRT? If you are thinking about testosterone replacement therapy (TRT), you should talk to a healthcare expert. Look for someone who is specialized in hormone therapy, urology, or endocrinology. These doctors know how to check your symptoms and run the right tests. They can create a treatment plan just for you. They will also keep track of your hormone levels and change your treatment if needed. This helps you get the best results and reduce side effects. It’s very important to have a skilled healthcare provider to help you during the process and give you support along the way. How do I find a reputable testosterone doctor near me? Finding a good TRT doctor nearby is an important step for fixing hormone issues or worries. Here are some tips to help you find a trusted TRT doctor: Research online: Begin by searching online for doctors or clinics that focus on hormone therapy or TRT near you. Look for reviews and testimonials. Check their credentials or certifications to see their skills in this area. Ask for referrals: Talk to friends, family, or coworkers. They might have gone through TRT or know someone who has. They can guide you to a good doctor or clinic from their own experiences. Talk to your main doctor: Your main doctor can give you advice or connect you with a specialist who focuses on hormone therapy or TRT based on your personal preferences. Look at professional directories. You can find them at places like the American Academy of Anti-Aging Medicine (A4M) or the American Urological Association (AUA). These directories can help you find doctors who focus on hormone therapy or TRT. Once you find some doctors you might like, the next step is to set up meetings with them. During these consultations, ask questions about their experience and how they treat patients. It's also good to learn about possible side effects or risks of TRT. Don't forget to check their credentials and licenses before you start any treatment. What questions should I ask before scheduling an appointment with a testosterone doctor near me? When you want to schedule an appointment with a possible TRT doctor, it’s good to ask some important questions. This way, you can make sure they are the right choice for you. Here are some questions you might think about asking: What experience and qualifications do you have for prescribing TRT? What tests will you do to see if I can get TRT? Will my treatment plan be made just for my needs and goals? What are the possible risks or side effects of TRT, and how will you watch for and manage them? How often will I need to come back for follow-up appointments, and what will happen during those visits? Are there any lifestyle changes or extra therapies that I should think about with TRT? Finding the right urologists is very important for your health. Don't hold back on asking these questions or any others that pop into your head during your first visit. It’s key to feel good and sure about the care you get. What are some common treatments that testosterone doctors recommend, and what are the potential side effects? TRT doctors might give you different types of testosterone. You could get injections, gels, patches, or pellets. The way you will be treated will depend on what you need and what you prefer. Some possible side effects of TRT are acne, water retention, more red blood cells, less sperm production, testicle shrinking, mood swings, and sleep apnea. However, not everyone will have these side effects. They can be different for each person. If you are thinking about TRT or have questions about treatments or side effects, it is a good idea to talk to a qualified healthcare professional. He or she specializes in hormone therapy. They can give you advice that is specific to your situation and medical history.

How can I find a clinic or lab near me to get my testosterone levels checked? Finding a clinic or lab near you to get your testosterone levels checked can be done by searching online directories like Yelp, Google Maps, or specific medical testing center websites like DiscountedLabs.com . You can also consult your primary care physician for recommendations on where to get this test done conveniently. You can buy a testosterone test without a doctor visit and insurance cheaply on Discounted Labs. We currently serve the following states: Alabama, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa (Des Moines), Kansas, Kentucky (Louisville & Lexington), Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana (Great Falls), Nebraska (Omaha & Lincoln), Nevada, North Carolina, New Mexico, Ohio (Cleveland & Akron), Oklahoma (OKC), Oregon, Pennsylvania, South Carolina, Tennessee, Texas, Utah (Salt Lake City), Virginia, and Washington. Sign up for our newsletter. You will know when we start expanding to other states. We cannot serve NY, NJ, RI, and AZ. Click on this map and enter your zip code to locate a lab nearby. NOTE: If you don't see any locations, please clear your browser cache and try again. CLICK HERE TO BUY A TESTOSTERONE TEST NEAR YOU.   Understanding Testosterone Testing Testosterone is a vital hormone for men, playing an essential part in sex-related maturation and features. The testicles are primarily responsible for producing it, with small amounts coming from the adrenal glands as well. Testosterone levels naturally decline as you age, beginning around age 40. Decreased testosterone levels can cause various medical issues, such as erectile dysfunction, fatigue, low libido, reduced muscle mass and bone density loss. A testosterone test, also known as a male hypogonadism test, measures the amount of testosterone present in your blood sample to diagnose conditions related to low T levels. It’s important to understand what a testosterone test is and why it’s necessary so you know when you need one and how to interpret the results accurately. Knowing when it’s time for a test can help prevent serious health problems down the line due to undiagnosed or untreated conditions associated with abnormal hormone levels. If you have symptoms like fatigue, depression, or decreased sex drive that may be related to low T levels, then it may be time for a testosterone test. Other medical conditions, such as PCOS or hypogonadism, might necessitate consistent tracking of hormone levels through testing - especially if they are being managed with drugs that could have further implications later. Age-related recommendations vary but generally speaking, men over 50 should consider getting tested more regularly than younger individuals since their hormones tend to fluctuate more quickly at this stage in life due to natural aging processes taking place within their bodies Accuracy of results can be affected by various factors, such as sample collection timing (e.g., morning versus evening samples) and fasting state (pre- or post-meals). To ensure reliable outcomes, it is important to take these into consideration when undergoing a testosterone test. Being knowledgeable about the diverse assessments for testosterone assessment is key to preserving one's wellbeing, so it is essential to be aware of the assorted tests that are obtainable. With that in mind, let us explore why regular testosterone testing is important for maintaining optimal hormone levels. Why Testosterone Testing is Important Testing for testosterone is a critical element in managing and sustaining healthy hormone levels among males. Low testosterone, or “low T”, can lead to a variety of health issues that can affect quality of life. Regular testing helps identify any hormonal imbalances early on so they can be addressed promptly. Understanding the significance of keeping hormone levels in a healthy state is essential. Testosterone is an essential hormone for male physical characteristics, energy levels, moods and fertility; its absence can cause severe medical issues. It also influences energy levels and moods, as well as sperm production and fertility. Unchecked low testosterone levels can lead to a range of medical issues, such as ED, PCOS, weariness, despondency, uneasiness, diminished libido and barrenness. By monitoring testosterone levels, medical professionals can gain insight into the patient's overall health and identify potential causes of symptoms such as ED or PCOS, while also tracking treatment progress if therapy is being used. Tracking changes in hormones over time allows them to identify potential causes for symptoms such as ED or PCOS and monitor treatment progress if therapy is being used to address a related condition. Furthermore, regular testing ensures that the body has adequate levels of testosterone necessary for normal metabolic and reproductive functions. Regular testing for testosterone is essential to maintaining good health, as it can help detect and prevent potential problems associated with low T. Therefore, understanding when to get tested for testosterone levels is an important part of keeping your hormones balanced. When to Get Tested for Testosterone Testosterone testing is important for men to understand and stay on top of. It's especially essential to get tested if you have symptoms like reduced libido or energy, or a medical condition that may influence your hormones. Knowing when it's best to get tested for testosterone levels, especially after making lifestyle changes, can help you maintain healthy hormone levels and prevent any health risks associated with low T or determine if testosterone therapy may be necessary. Signs of a need for testosterone assessment may include impotence, tiredness, gloominess, reduced muscle mass/power, raised body fat levels, decreased bone density and hair loss - all of which should not be disregarded. If these symptoms are present, including changes in sexual function, lower sex drive, physical changes, and emotional changes, it is advisable to seek medical advice and have a blood test done to check for symptoms of low testosterone or high testosterone. Certain medical conditions, such as PCOS, adrenal gland disorders and type 2 diabetes, can lead to abnormal testosterone levels in men which may require regular monitoring. Your physician will advise you when the most suitable time to be examined is, depending on your particular requirements; therefore, make sure to adhere carefully to their counsel. Age-related recommendations also play an important role in deciding when to get tested for testosterone levels since natural production decreases with age, starting around 30 years old but at different rates depending on the person’s lifestyle habits and genetics. For those aged 18–70, it is suggested to get their testosterone levels checked every five years or sooner if they notice any alterations in physical capability or mental health. It is essential to consider individual circumstances when determining the necessity of a testosterone test, so consulting with your doctor or healthcare provider is recommended. The next heading will discuss different types of tests available for measuring testosterone levels in the body. Types Of Testosterone Tests Testosterone is a hormone found in both men and women, but it’s more prevalent in males. Understanding testosterone levels is critical for achieving and maintaining optimal health, as it influences muscle growth, bone density, sexual performance, fertility, energy levels and even mood. It plays an essential role in muscle growth, bone density, sexual performance, fertility, energy levels and even mood. That's why understanding testosterone testing is so important. Healthcare professionals rely on two reliable methods to measure one's total and free circulating serum concentration, namely immunoassays and liquid chromatography/mass spectrometry (LC/MS), with saliva tests and urine tests being the other available options. However, only the former two have been scientifically validated for clinical use. Measuring free testosterone can be accomplished using either immunoassay or LC/MS, but the latter is known to provide more precise results due to its capacity to detect lower hormone concentrations with greater accuracy than other methods. On the other hand, total testosterone and bioavailable testosterone measure all forms of circulating testosterone, including both free and bound types, respectively; however, they are also beneficial in determining how much active hormone is available within your body at any given moment as opposed to simply measuring overall amounts present in circulation. Testosterone tests are important for monitoring and diagnosing hormonal imbalances in men. Knowing the various testosterone tests accessible is vital to guaranteeing precise results from your blood test. Let's explore other methods of gauging hormone levels through blood testing. Types Of Blood Tests For Measuring Hormone Levels Blood tests are the go-to method for gauging hormone levels in the organism. Two of the most popular blood tests for measuring testosterone levels are immunoassays and LC/MS, with immunoassays being favored due to their convenience while LC/MS provides more precise results. Immunoassays have become widely used due to their ease, while LC/MS provides more accurate results, especially when detecting small changes over time. Immunoassays use antibodies to detect hormones in a sample of blood or other bodily fluid. The test measures total testosterone, which includes both free and bound forms of the hormone. Although this method is reasonably quick and affordable, it is susceptible to substances like steroids that could affect the outcome. Liquid chromatography/mass spectrometry (LC/MS) is a more precise technique that separates molecules based on size and electrical charge before analyzing them using mass spectrometry. This technique permits the quantification of free testosterone and its metabolites, such as DHT. It also has greater sensitivity than immunoassay, meaning it can detect smaller amounts of hormones present in the sample. However, this method is more expensive and takes longer to get results back from a laboratory setting than an immunoassay does. Accurately assessing hormone levels is best done through blood tests, which provide a comprehensive picture of an individual's health. Saliva and urine tests also offer valuable insights into hormonal imbalances, making them useful complementary tools for monitoring hormones. Saliva And Urine Tests For Measuring Hormone Levels Saliva and urine tests are two of the most commonly used methods for measuring hormone levels, including testosterone. Saliva testing has become increasingly widespread in recent times, due to its convenience and precision. Urine testing has been around longer but is not as accurate as saliva testing. Saliva Tests: Saliva tests measure free testosterone, which is the active form of testosterone circulating in your bloodstream. This type of test can be done at home with an at-home kit or by visiting a lab for collection. Saliva testing offers a more precise assessment than blood or urine tests, since it only measures the active hormones in your body. Urine-based measurements, which measure total testosterone levels (including both free and bound forms of the hormone circulating in your bloodstream), can provide insight into overall hormone levels. However, this method may not give you an accurate picture due to potential influences from external factors such as medications or lifestyle choices like stress or dieting that could affect how much free testosterone is available to perform its duties within cells and tissues throughout the body. Saliva tests, on the other hand, can measure levels of free testosterone and other sex hormones more accurately, making them a preferred method for assessing hormone levels in individuals with sexual problems or conditions that can affect SHBG levels. Therefore, it is important to consider all possibilities when assessing one's hormone levels using urine or saliva tests. Saliva and urine tests are both effective ways to measure hormone levels in the body, however, they each have their own pros and cons. For accurate results, one must take into account aspects like collection procedure, storage conditions and lab technique. Moving on from here, we will discuss these influencing factors in more detail. Factors Affecting Accuracy Of Results Accuracy of testosterone test results is essential for getting an accurate diagnosis and treatment plan. The accuracy of a testosterone test can be affected by many things, such as the type of sample used, the testing method (such as CLIA-certified clinical laboratory tests), changes in hormone levels that come with getting older, medical conditions like Polycystic Ovary Syndrome (PCOS), drugs taken before the test, and other lifestyle choices. The most widespread way to gauge testosterone concentrations is via serum or plasma specimens. These samples are collected by drawing blood from a vein in the arm or hand using a needle. For optimal accuracy, samples should be processed in a laboratory within 24 hours of collection. Immunoassays are typically employed as screening tests due to their affordability, but they possess lower precision than LC/MS, which is more reliable yet costlier. Saliva and urine tests are also available but these tend to have lower accuracy rates than serum or plasma tests because hormones can bind with proteins in saliva or become diluted in urine, making them harder to detect accurately. It is important to note that the accuracy of test results can also be affected by the testing laboratory used, as different labs may have varying levels of expertise and equipment. As men age, their adrenal glands produce smaller amounts of testosterone, leading to a gradual decline in total testosterone concentrations. Thus, it is advised that males over 40, especially older men, have their testosterone levels examined frequently, even if they are not showing any indications of low T such as erectile dysfunction or a decrease in body hair growth; doing so can help to avert potential harm before it's too late. Regularly checking testosterone levels for older men is crucial in avoiding potential damage caused by the gradual decline in total testosterone concentrations. FAQs in Relation to Testosterone Test Near Me Where can I get my testosterone levels checked? You can get your testosterone levels checked without a doctor visit by ordering an at-home blood test online. These tests offer a handy solution, enabling you to take your sample in the privacy of your own home and send it away for analysis. Results typically arrive within days, giving you accurate information about hormone levels that could be impacting health and fitness goals. With access to this data, individuals can make informed decisions about their health care needs with confidence. How much does testosterone level test cost? The cost of a testosterone level test depends on the type and complexity of the test. Generally, basic tests range from $50 to $100, while more complex tests can cost as much as several hundred dollars. Most insurance policies will offer some form of reimbursement for the expenses associated with these blood tests. Additionally, many online testing services offer discounted prices for those who order multiple tests at once. Discounted Labs has the most affordable testosterone test in the United States. Can I get a testosterone test without a doctor's referral? Yes, you can get a testosterone test without a doctor's referral. Most online blood testing services provide convenient access to lab tests with no need for a physician's order or visit. A simple online platform and payment process make it easy to access lab tests without a doctor's prescription. Tests are then sent directly to the laboratory, where results are available within days, allowing individuals to monitor their health quickly and conveniently from home. What doctor should I see for testosterone? For a comprehensive assessment of your health, including any underlying causes that may be contributing to changes in your testosterone levels, an endocrinologist is the best professional to consult with. An endocrinologist specializes in hormone-related conditions and can provide a comprehensive assessment of your health, including any underlying causes that may be contributing to changes in your testosterone levels. An endocrinologist can offer advice regarding the most effective way to address any hormonal discrepancies that may be present. Conclusion In conclusion, it is important to understand the different types of testosterone tests and when to get tested for accurate results. Blood spot finger prick tests are not recommended as they are not always reliable. At-home test kits should also be avoided due to their inaccuracy in measuring testosterone levels accurately. If you're looking for a reliable and convenient way of testing your testosterone levels, look no further than our online blood test near me, which can provide an easy solution without needing a doctor visit. Take control of your health today and get the testosterone test you need quickly, conveniently, and affordably with DiscountedLabs.com - no doctor visit required!

The Top Boner Killers What Causes an Erection? The Role of Blood Flow An erection begins when the penile smooth muscle relaxes, enabling blood to fill the corpus cavernosum, two cylindrical “caverns” of spongy tissue running within the penis. Stage two of the erection process occurs with this infilling of the corpus cavernosum. The inflow of blood expands the spongy tissue, which begins to pinch off the emissary veins of the penis, decreasing outflow, and—voila!—the erection begins to build. Continue reading this article to find out what the top erection killers are and how to avoid them. For more details on how erections work, continue reading this article.   Why Can't I Maintain an Erection? Top Erection Killers It is estimated that some degree of erectile dysfunction (ED) affects half of all men over the age of 40 and that 150 million men worldwide suffer from ED. There are many reasons a man might not be able to maintain a healthy erection, many of which play into our daily habits and lifestyle choices. If you are having trouble getting or maintaining an erection, consider testing for ED, as an imbalance of hormones could be the root of the problem. Many things that have the potential to hurt our general and sexual health are culturally acceptable so they simply never cross our minds. Low Testosterone: Testosterone plays a critical role in our sexual health and can be directly linked to libido. Not only do lower levels of testosterone equal lower sex drive, but also it can lead to venous leakage. This condition is characterized by the inability to “pinch off” emissary veins that carry blood away from the penis. This results in blood leaking out of the corpus cavernosum as quickly as it can be filled, making a lasting erection impossible to maintain. If you are having erectile difficulties, a simple testosterone test is a great first step on the road to treatment. Loss of Morning Erections: Morning erections, or the lack thereof, can be a good way to begin troubleshooting if you have psychological erectile dysfunction. The idea is that if you can achieve an erection by any means, nighttime or otherwise, then your issue is probably more mental than physical. Morning erections oxygenate erectile tissue and fight off penile fibrosis, keeping the penis elastic and healthy. High Blood Pressure: High blood pressure often results in hardening arteries, constricting blood vessels, and damage to the thin membrane that lines our hearts and veins. This restricts the amount of blood your body can readily provide to your penis when it is “go time.” Not only can high blood pressure kill an erection, but it can lead to a host of other, much more immediate, medical complications, including heart attack and stroke. Any Cardiovascular Risk Factor: Almost anything hard on the heart and cardiovascular system is going to lead to erectile dysfunction. The reason is simple: erectile dysfunction is strongly related to endothelial dysfunction, where the delicate lining of your arteries becomes damaged and does not output nitric oxide as it should. This is the primary reason that lifestyle is so critical: exercise, weight management, and diet all powerfully affect how your body carries blood and oxygen to your organs. Cholesterol Management: High cholesterol has been linked to erectile dysfunction due to its direct correlation with elevated LDL or “bad cholesterol.” LDL carries cholesterol to the arteries, which, when oxidized, damages artery walls. Contrary to HDL, which aids the body in eliminating excess cholesterol, elevated levels of LDL can significantly impact your heart, cardiovascular system, and ultimately, your erectile health. Bike Seats: Many standard bike seats can damage the pudendal nerve that is connected to the penis. If you have done a lot of bike riding recently and have erectile dysfunction, this is something to consider. The solution can be as simple as changing out your bike seat. Bisphenol-A and Phthalates: Our modern environment is filled with toxins that have been proven to damage the reproductive and sexual functions of animals, and as primates, men are no exception. Bisphenol A and phthalates are chemical compounds used in the production of polycarbonate plastics that litter our world today. These chemicals are filled with endocrine disruptors and xenoestrogens that, over time, can severely impact one’s hormonal and sexual health. Prolactin: Prolactin is a hormone that stimulates breast development and milk production in women; it serves no known normal function in men. However, high prolactin can decrease testosterone, lower libido, and cause sexual dysfunction. This is because high prolactin suppresses the secretion of gonadotropin-releasing hormone, which stimulates the production of testosterone in men and estrogen in women. Estradiol (E2): Estradiol is the primary form of estrogen during our reproductive years. In men receiving testosterone replacement therapy (TRT), the body can sense increasing levels of testosterone and aromatizes 0.4% of it to estradiol to compensate. Very high and low E2 in relation to testosterone levels can sabotage TRT results, leading to diminished libido. Testing for ED will give you a good idea of what hormones you have an excess or lack of. Excess Weight: Being overweight can lead to a plethora of health complications, including heart disease, high blood pressure, diabetes, and many more. Excess weight has also been proven to lower testosterone, increase estrogen, raise inflammation, and boost insulin levels. Together, these factors can significantly impact your sexual life. Smoking: Not just cigarette smoke, but any sort of burning inhalant is bound to damage your lungs and cardiovascular system. Smoke can also cause arteries to constrict and narrow, allowing less blood flow to the penis. Medications: Many, many medications will kill erections. Some lower testosterone. Some raise prolactin. Some have a sedating effect by raising serotonin levels. Some alter dopamine functions. The bottom line is that if you are on medication and having erectile difficulties, this is one of the first places that you should look. Depression: Depression is an acutely debilitating condition, not just mentally, but physically as well. Depression causes stress to the body, which, in turn, lowers testosterone. Depression also correlates with heart disease, as depressed individuals are less likely to be consistently physically active. Depression also elevates cortisol levels, which destroy neurons in the brain. All of these factors can lead to erectile dysfunction, which can often worsen depression. This bidirectional relationship reinforces the need to take care of one’s mind as well as body. Recreational Drugs: Many men do not realize that even something as relatively benign as marijuana use can affect their sex life. However, it has been proven to lower testosterone and damage the body’s cardiovascular system. Harder drugs, such as cocaine, heroin, ecstasy, or prescription painkillers, can have even more detrimental effects. They greatly increase one’s risk of developing heart disease, cause plaque buildup on artery walls, and severely reduce ejaculatory volume. In short, drugs age the body faster than normal, and that includes the penis. Consider carefully before indulging in your favorite recreational substances, as they can destroy gonad function, lower testosterone levels, and potentially lead to heart failure. Lack of Sleep: Not getting enough sleep at night can significantly lower testosterone levels, leading to erectile dysfunction. Ensure you get quality sleep to maintain sexual health. Watching TV in Bed: Spending too much time watching TV in bed can lead to a sedentary lifestyle, which negatively affects erectile function. Regular physical activity is crucial for maintaining sexual health. Watching Comedy Series: Engaging in light-hearted activities like watching a comedy series can reduce stress and improve overall well-being, which is beneficial for sexual health. Does More Testosterone Equal a Better Sex Life? As we’ve discussed, testosterone plays a critical role in stimulating sex drive and developing and maintaining erections. Low levels of testosterone have been directly linked to health conditions and dulled libido. However, this is not indicative of a simple “more is more” relationship between T and sexual health. Testosterone is a hormone that must be balanced properly, as an influx of it signals your body to increase the production of estradiol and prolactin. Watching too much TV, especially in bed, can lead to a sedentary lifestyle, which negatively impacts testosterone levels and erectile function. Make sure to closely monitor your T levels with a. To achieve ideal results, it is important to keep testosterone levels between 500 and 1000 ng/dL while ensuring your levels of estradiol and prolactin do not proportionately increase. It is not uncommon for certain prescription medications to interfere with TRT as well. Many antidepressants, blood pressure medications, and cholesterol-lowering agents have been known to dampen sex drive, even with the use of testosterone replacement. Finally (and most importantly), make sure you are attracted to the person you are intimate with. Lack of attraction to our sexual partners can be the biggest hurdle in achieving a strong erection. All the testosterone and lifestyle changes in the world won’t result in an erection if you simply don’t want to have sex with someone. Porn addiction has also been linked to ED, as it desensitizes us to nudity and intercourse. While there are many physical contributors to ED, there are unquestionably psychological elements as well. So before testing for erectile dysfunction, make sure that you are taking care of your body and mind while properly balancing the hormones your body needs for sexual activity. References   4 Causes of Erectile Dysfunction You Might Not Know 7 Factors That Can Affect Erections The Top Erection Killers Erectile Dysfunction Impotence (Erectile Dysfunction) Erectile Dysfunction (Impotence) Erectile Dysfunction 5 Common Erectile Dysfunction Causes Erectile Dysfunction: Symptoms and Causes Erectile Dysfunction: Symptoms and Causes Erectile Dysfunction (ED): Causes, Diagnosis & Treatment Medications Most Commonly Associated With Erectile Dysfunction: Evaluation of the Food and Drug Administration National Pharmacovigilance Database Erectile Dysfunction: Viagra and Other Oral Medications 5 Factors That Cause or Worsen Erectile Dysfunction (ED) Which Drug for Erectile Dysfunction? Drugs Linked to Erectile Dysfunction Erection Problems (Erectile Dysfunction)    

Estrogen in Men: Myths and Realities of High Estradiol In men, the liver, fat cells, and other cells aromatize testosterone to produce estradiol, which is a hormone that is more prevalent in women than in men. Estradiol is responsible for healthy bone density and cholesterol, but its role in men’s sex drive, body composition, and other variables is a source of great debate. It is crucial to understand that estrogen plays a significant role in male reproductive health, particularly in the processes of sperm production and maturation within the testes. Many men on testosterone replacement therapy (TRT) initially fear high estradiol levels since they fear it causes water retention and gynecomastia. However, it is important to note that fat cells play a significant role in the production of aromatase, which can lead to higher levels of estradiol in the body. Below, we will discuss why most men on TRT do not have to be overly concerned about the estradiol lab ranges that are ill-fitted for men on TRT, as the ranges of LabCorp and Quest were not derived from a dataset of men on TRT who usually have higher total testosterone blood levels. What is Estradiol and Why is it Important for Men's Health? Estradiol is a type of estrogen hormone that plays a crucial role in men’s health. Often referred to as a 'female sex hormone,' estradiol also plays a crucial role in male health. It helps regulate bone density, cognitive function, libido, and mood. However, high levels of estradiol in men can lead to negative effects like decreased muscle mass, increased body fat, and hormonal imbalances. Men’s liver, fat, and other cells aromatize testosterone to produce estradiol, a hormone that is more prevalent in women than in men. Estradiol is responsible for healthy bone density and cholesterol, but its role in men’s sex drive, body composition, and other variables is a source of great debate. Many men on testosterone replacement therapy (TRT) initially fear high levels of estradiol since they fear it causes water retention and gynecomastia. We will talk about why most men on TRT do not need to worry too much about the estradiol lab ranges that do not work well for them because LabCorp and Quest did not get their ranges from a group of men on TRT who usually have higher total testosterone blood levels. High levels of estradiol in men are associated with abdominal obesity and an increased risk of cardiovascular disease. What is High Estradiol?: Predicted Blood Levels in Young and Older Men on TRT Transcript of video below: There needs to be more clarity on the subject since LabCorp and Quest have very narrow, sensitive estradiol test ranges. Those estradiol test ranges were primarily derived from men not on testosterone replacement therapy. Men on TRT tend to have higher testosterone levels than men not on testosterone replacement. So, believe it or not, a paper published many years ago predicts estradiol and DHT levels in men given different doses of testosterone. This study examined what happens to blood levels of testosterone, estradiol, and DHT when injecting different testosterone doses in young and older men. This study was very nicely done at the Boston University School of Medicine by well-known testosterone researchers. Dr. Basin is one of them and has done excellent work for the last 30 years. Video: How to Predict High Estradiol in Men Testosterone is the precursor hormone for estradiol. The aromatization of testosterone in the liver, fat, and other cells, including the testes, results in estradiol, a hormone that is more prevalent in women than men. Nature created it for a reason. It is responsible for healthy bone density and cholesterol, but its role in men's sex drive, body composition, and other variables is a source of great debate. Many anti-aging or men's health clinics prescribe aromatase inhibitors (AIs) to men who start testosterone replacement therapy (TRT). Higher estradiol blood levels in the presence of low testosterone can cause breast tissue growth (gynecomastia) in some men and possibly other issues. Some people speculate that high estradiol levels can also lead to difficulty achieving or maintaining an erection, but no scientific papers have been published on this subject. Since higher testosterone blood levels can result in higher estradiol levels in men, the belief is that using an AI will prevent breast tissue growth and erectile dysfunction by lowering any potential increase in estradiol. However, we have no data on how high is too high when it comes to this hormone in men using testosterone therapy. Emerging data show that low testosterone-to-estradiol ratios may correlate more closely to infertility, gynecomastia, and erectile problems than high estradiol levels alone. The truth about these speculations is starting to emerge, but we still need more data to say what the upper value of the optimal range of estradiol in men is. We have a lot of evidence about the lower side of the optimal range since it has been found that estradiol blood levels below 10–20 pg/mL can increase bone loss in men. A recently published study also nicely demonstrated that low estradiol could be associated with higher fat mass and lower sexual function in men. So, be careful when a clinic wants to put you on an aromatase inhibitor without first justifying its use. Increased Aromatase Activity and the Role of Aromatase Inhibitors in Men Aromatase is an enzyme that converts testosterone to estradiol, a form of estrogen. Germ cells, along with Leydig cells, are significant sources of estrogen production in the testes. In men, aromatase activity is typically low, but certain conditions can increase it, a process known as aromatase overexpression. This can lead to higher levels of estradiol in the body, which can have negative effects like decreased libido and muscle mass in the adult male. However, some studies suggest that moderate increases in estradiol may have cardiovascular benefits. One condition that can increase aromatase activity and therefore estradiol levels is aromatase excess syndrome, a genetic condition that affects both males and females. It’s important for men to maintain healthy levels of both testosterone and estradiol, and understanding the role of the aromatase enzyme, especially in conditions like aromatase excess syndrome, is crucial in managing estradiol levels. Estradiol in Men After Different Testosterone Doses: Study Details This study's findings were published in the Journal of Clinical Endocrinology and Metabolism in 2010. The fantastic thing is that nobody has reviewed it, even though it's probably the most important paper on what happens to estradiol and DHT in men on TRT. The study enrolled 51 young men aged 19 to 35 and 52 older men aged 59 to 75. These men were given a gonadotropin-releasing hormone agonist to shut down their gonadotropins, LH and FSH, testosterone, estradiol, and DHT. So, these were courageous volunteers who were willing to have their hormones wholly shut down. So, why did they do this? They did it because the researcher wanted to start from zero regarding hormones. So, those men were given injections of different doses of testosterone enanthate, 25, 50, 125, 300, and up to 600 milligrams a week for five months. And the researchers measured the testosterone, estradiol, and DHT blood levels. Unfortunately, they used the old estradiol test based on immunoassay. This estradiol test may not be the best for accurate estradiol testing. The use of an ultra-sensitive estradiol test is more accurate since it has no interference from CRP or inflammatory markers Usually, the sensitive estradiol is 20% lower than the estradiol levels measured by the old test. Let's assume that most of these men did not have inflammation. Here are their baseline characteristics. Interestingly, they were even exposed to such high doses of testosterone. So, after a four-week controlled period, they were given a testosterone blocker, the gonadotropin-releasing hormone agonist that shuts down gonadotropins. This drug is used to treat prostate cancer. They were randomized to receive weekly injections of testosterone enanthate for 20 weeks. The researchers found an issue with the higher testosterone dose in older men, with a few more side effects. They stopped a few men from continuing with the 600 milligrams of testosterone weekly. And then the randomization was limited to 25, 50, 125, and 300 milligrams of testosterone injections weekly. I've warned people not to use high testosterone doses, especially older people with comorbidities and heart problems. Increased blood pressure and tachycardia are some of the side effects listed in the study paper. So, what you see here are serum estradiol E2:T ratios. We talk about ratios on ExcelMale.com. Here are the opposite DHT and T ratios from what I typically talk about when dividing T by E2. And the black bars are younger men, and the white bars are older men. So, this is total estradiol, free estradiol, total DHT, and free DHT. And when we talk about free, what does that mean? It is the unbound estradiol and unbound DHT that aren't bound by sex hormone-binding globulin. And those two free estradiol and free DHT tests are rarely tested in clinics. DiscountedLabs.com does provide a free estradiol test for those who are interested. But since there are no studies about free estradiol blood levels in men, it's hard to say what a good free estradiol level is. High Estradiol in Men on TRT Most men on TRT initially fear high estradiol since they fear it causes water retention and gynecomastia. While high estradiol levels in men can cause gynecomastia, in women, similar hormonal imbalances are linked to an increased risk of breast cancer. They feel puffy; they may have more sensitive nipples. I will discuss this in another video because those symptoms are usually not connected to high estradiol per se when men have moderate to high testosterone levels. The most common cause of edema, or the problem of holding onto water weight, is a slowdown in sodium metabolism in the kidneys brought on by testosterone and androgens. Sodium (salt) retention happens in the first few weeks, especially with higher TRT doses in older men. The stimulating effects of testosterone may be to blame for the sensitive nipple issue, which typically does not cause gynecomastia. However, it is important to note that symptoms of high estrogen in men can also include swelling or enlargement of breast tissue, erectile dysfunction, infertility, depression, and delayed puberty. So, as you can tell, total E2, free E estradiol, and DHT increase with increasing testosterone doses, and this increase is much more pronounced in older men. It’s good to mention that these volunteers were not fat men. The increased fat mass has been linked to increased estradiol levels, which are often measured through body mass index (BMI). These are men with a BMI of around 26, which is not a high number. But anyway, we do see an increase. And older men, in white, tend to have a higher estradiol increase. DHT is the same thing. Although the differences were not as noted between young and old, you can tell here the free DHT. When you divide estradiol into testosterone, that’s when you see a decrease. Estradiol increases to a higher degree than testosterone, so the ratio of E2 divided by T decreases. The total DHT to T ratio is the same; it decreases as we increase the testosterone dose, but not as fast as the estradiol. It is essential to mention that 0.3% to 0.4% of testosterone is aromatized into estradiol. That’s a very tiny amount; that’s 0.4%. The conversion of testosterone to DHT by 5 alpha-reductase is around 10%. That’s why you see the scales a little more prominent on the DHT side. What to Know About Estrogen in Men Estrogen is commonly associated with women, but men also have this hormone in their bodies. The testes and adrenal glands are primarily responsible for producing estrogen in a male body. Estradiol is a type of estrogen that plays an important role in maintaining bone health, regulating cholesterol levels, and supporting brain function. Low levels of estradiol in men can contribute to a variety of health issues, such as decreased libido, erectile dysfunction, and osteoporosis. It's important for men to understand their hormonal balance, including their levels of estradiol, and work with a healthcare provider to address any imbalances or concerns related to erectile function and hormone balance. Buy an affordable, ultrasensitive estradiol test:   Understanding Androgens and Estrogens Estradiol is a type of estrogen that is found in both men and women. While it is often associated with female reproductive health, estradiol plays an important role in male health as well. Estrogens influence male reproductive function by maintaining a hormonal balance between estrogens and androgens, which is crucial for male fertility. In fact, it is responsible for regulating bone density, cholesterol levels, and even mood. When there is high estradiol in men, it can lead to a variety of health problems. Understanding the balance between androgens (male hormones) and estrogens (female hormones) is crucial for sexual development and maintaining optimal health for both men and women, especially in relation to the menstrual cycle. Risk Factors of Having High Estradiol in Men Estrogen is often associated with females, but it also plays a crucial role in men's health. High or low levels of estrogen in males can have negative impacts on their overall health. Men who have higher than normal levels of estrogen, also known as estrogen, may experience breast enlargement, erectile dysfunction, infertility, and other issues. On the other hand, men with lower than normal levels of estrogen may experience decreased bone density, muscle mass, and sex drive. It is important for men to maintain balanced estrogen levels through proper diet, exercise, and medical treatment if necessary. However, it is important to note that too much estrogen, also known as high levels of estrogen, can also be harmful to men's health, and it is important for individuals to monitor their estrogen levels and consult with a doctor if they have any concerns. How Men Can Keep Their Estrogen Levels Balanced Estrogen is typically associated with women, but men also have this hormone in their bodies. Estradiol is the most potent form of estrogen in men and plays a crucial role in maintaining bone density, sperm production, and sexual function. However, too much or too little estradiol can cause various health problems. Men can keep their estrogen levels balanced by maintaining a healthy weight, avoiding exposure to environmental toxins, managing stress levels, and getting enough sleep. A balanced diet rich in fiber and phytoestrogens, along with proper monitoring and control through hormone replacement therapy, may also help regulate estrogen levels in men, ensuring healthy sperm production. Normal Estrogen Levels in Men Estrogen is often thought of as a female hormone. However, it's also present in men, just at lower levels. One type of estrogen found in men is estradiol. Normal levels of estradiol in men vary depending on age and other factors. In general, levels range from 10 to 60 pg/mL. If levels are too high or too low, it can lead to health issues such as osteoporosis, sexual dysfunction, and mood changes. Men should discuss their estrogen levels with their healthcare provider to ensure they are within a healthy range for their age and overall health status. This includes monitoring the amount of estrogen in their body, as there are two main types of estrogen in men: estrone and estradiol, and an imbalance of these hormones can have negative effects on their health. Gynecomastia and High Estradiol in Men Gynecomastia is a condition that causes men to develop breast tissue. Studies on male mice, such as αERKO and ArKO models, highlight the effects of estrogen deficiencies on sexual behavior and fertility. One of the underlying causes of gynecomastia is an imbalance of hormones, including estradiol. Estradiol is a form of estrogen that is typically found at higher levels in women. However, men also have small amounts of estradiol in their bodies. When the balance between estradiol and testosterone is disrupted, it can lead to the development of breast tissue in men. Treatment for gynecomastia may involve addressing the hormonal imbalance through medication or surgery, depending on the severity of the condition. You can buy a gynecomastia lab test panel on Discounted Labs. Low Estradiol Can Cause Loss of Libido and Erectile Dysfunction One of the significant impacts of estradiol deficiency in men is the loss of libido. Low levels of estradiol can lead to decreased sex drive, which can cause problems in relationships and affect overall quality of life. However, it's essential to note that there are other factors that can impact libido as well, such as stress, depression, low testosterone levels, and a lack of sexual activity. If you're experiencing a loss of libido, it's important to talk to your doctor to determine the underlying cause and discuss possible treatment options. A Study Helps to Predict Normal Estradiol and DHT Test Levels in Men on TRT Most men on TRT don't have to be so concerned about the LabCorp or Quest estradiol ranges that usually scare people because they're always high. And there is statistical significance in the baseline values of young and older men. DHT increases were higher in older men. In younger men, usually, that's also connected to total testosterone and is also related to higher libido. Older men had lower DHT, which was also linked to their lower testosterone. Sex hormone-binding globulin (SHBG) is also higher in older men. The researchers in this study came up with a model with factors to predict the estradiol and DHT response curves. They provided two equations for young men (estradiol and DHT) and two for older men. Using those equations, you can roughly estimate the predicted estradiol and DHT levels for different testosterone blood levels. These equations enable us to see what is considered a “normal” estradiol level instead of using estradiol lab ranges that are ill-fitted for men on TRT. As previously mentioned, the estradiol ranges of LabCorp and Quest were not derived from a dataset of men on TRT who usually have total testosterone blood levels over 600 ng/dL (many men on TRT have T levels of 1000 ng/dL or more!). The Importance of Preserving Proper Levels of Estradiol in Men Our bodies transform 0.4% of testosterone into estradiol to balance the potentially negative effects of testosterone alone on lipids and other variables. If you have “high” testosterone, your estradiol should be “high.” Treating that estradiol with an aromatase inhibitor may not be needed and can potentially crash your estradiol level. Estradiol has essential roles in men, including the regulation of hormone levels. Estradiol comes in to protect us from higher testosterone and helps improve lipids, HDL, and endothelial function. Women tend to live longer than men because they have more estrogen to protect them against the cardiovascular risks we are all exposed to. So, don't freak out when you see the 60s, even in the 70s, depending on how high your testosterone is. And the only problem we're having in this field is that we still need to do a study that goes after symptomology depending on estradiol blood levels when we control testosterone. We know that estradiol levels under 15 picograms per milliliter cause problems with bone density and even fat gain. Many members of ExcelMale.com say that their penile sensitivity decreases when they have low estradiol. We do not know what high estradiol in men means in relation to estradiol blood levels in relation to testosterone. Can high estradiol in men on TRT with relatively high testosterone blood levels cause issues? Is there a proper and healthy testosterone-to-estradiol ratio?. If somebody is, let's say, at 1,275 ng/dL of testosterone and 64 pg/mL of estradiol, is there any consequence to that? We don't know. And the problem I'm seeing is that most of you guys are assuming too much; you're assuming that because you're holding water or you have sensitive nipples, you have high estradiol. And you start treating with an AI without even testing your blood levels of estradiol, especially using the sensitive assay. That concerns me because once you start treating with an AI, you can crash your estradiol. “Crashed estradiol” has become one of the most significant traffic source keywords for ExcelMale because people are experiencing that more and more. I hope you enjoyed the presentation. Please remember to subscribe to the ExcelMale forum and the ExcelMale YouTube channel, and make sure that you click on that little bell that will tell you when I upload new videos. Thanks a lot, and stay safe. Estrogen Dominance and Hormonal Imbalance Estrogen dominance occurs when there is an imbalance between estrogen and testosterone levels in the body. This hormonal imbalance can lead to a range of symptoms, including weight gain, mood swings, and decreased libido. Men experiencing estrogen dominance may notice an increase in body fat, particularly around the abdomen, and may struggle with emotional changes such as irritability or depression. Additionally, estrogen dominance can negatively impact overall health by contributing to conditions like insulin resistance and cardiovascular issues. Maintaining a proper balance between estrogen and testosterone is crucial for optimal health and well-being. Exposure to Endocrine Disruptors and Environmental Toxins Endocrine disruptors and environmental toxins can significantly impact estrogen levels and overall health. These substances, found in everyday items like plastics, pesticides, and personal care products, can mimic the effects of estrogen in the body, leading to hormonal imbalances. When these toxins enter the body, they can bind to estrogen receptors, disrupting the natural hormonal balance and potentially causing a range of health problems. It’s essential to be aware of these environmental toxins and take steps to minimize exposure, such as choosing organic foods, using natural personal care products, and avoiding plastic containers. Other Non-Reproductive Effects of High Estrogen High estrogen levels can have a range of non-reproductive effects on the body, impacting various aspects of health and well-being. Some of the common non-reproductive effects include: Weight gain and obesity: Elevated estrogen levels can lead to increased body fat, particularly around the abdomen, contributing to obesity. Mood swings and emotional changes: High estrogen can cause mood swings, irritability, and even depression. Fatigue and low energy: Men with high estrogen levels may experience chronic fatigue and a general lack of energy. Insomnia and sleep disturbances: Hormonal imbalances can disrupt sleep patterns, leading to insomnia and poor sleep quality. Skin problems: High estrogen levels can cause skin issues such as acne and rosacea, affecting overall skin health. Maintaining balanced estrogen levels is essential for overall health and well-being, and addressing any hormonal imbalances can help alleviate these symptoms. Foods that Lower Estrogen: Cruciferous Vegetables and Sulforaphane Cruciferous vegetables, such as broccoli, cauliflower, and Brussels sprouts, are known for their ability to help lower estrogen levels in the body. These vegetables contain a compound called sulforaphane, which has been shown to support the detoxification of excess estrogen. Incorporating cruciferous vegetables into your diet can help maintain healthy estrogen levels and support overall hormonal balance. Additionally, these vegetables are rich in fiber and other essential nutrients, making them a valuable addition to a healthy diet. By including more cruciferous vegetables in your meals, you can naturally help regulate estrogen levels and promote better health. Buy an affordable, ultrasensitive estradiol test:   I hope you enjoyed the presentation. Please remember to subscribe to the ExcelMale forum and the ExcelMale YouTube channel, and make sure that you click on that little bell that will tell you when I upload new videos. Thanks a lot, and stay safe. More information about high estradiol in men Citations Understanding Blood Test Results: Estradiol (Male) Aromatase Inhibitors in Men: Mechanisms and Benefits Aromatase Inhibitors: No More, No Less Estrogen in Men: Understanding Its Role and Effects The Role of Estradiol in Male Reproductive Health Effects of Estrogen on Men's Health Estrogen in Men: What You Need to Know Estrogen's Impact on Men's Health: A Scientific Study When to Take Anastrozole with Testosterone Estrogen and Male Health: Research Findings The Role of Estrogen in Men's Health When to Use Aromatase Inhibitor with TRT What Causes High Estradiol Levels in Males?  

TRT Blood Work Tests For Monitoring Men on Testosterone Therapy Before undergoing testosterone replacement therapy (TRT), it’s vital to obtain a number of blood tests, which require a blood sample. The main blood tests to measure are total and free testosterone, hematocrit, PSA, estradiol, HDL cholesterol and others. Pre-treatment testing provides doctors with baseline values to diagnose hypogonadism (low testosterone) and assess overall health. Baseline tests are also conducted during TRT as well, ensuring that doctors can adjust TRT dose and catch side effects before they become an issue. Hematocrit Test PSA Test Estradiol Test Blood Pressure Estimated Glomerular Filtration Rate eGFR Liver Enzymes Test TSH Test Free T3 Test Total Testosterone Test Free Testosterone Test Ferritin Test HDL Cholesterol Test Click here for the Pre- TRT panel and the TRT panel (after 6-8 weeks on TRT) But do you know why these tests are needed or what they mean? Below, you’ll find some of the main blood tests that have been shown to be affected by TRT, so doctors measure them before and during therapy to prevent or manage side effects: Understanding Testosterone Blood Tests A testosterone blood test is a crucial diagnostic tool used to measure the level of testosterone in your blood. Testosterone, produced by the adrenal glands and gonads (testes in men and ovaries in women), plays a vital role in the development and maintenance of male reproductive tissues, bone density, and muscle mass. This test is commonly employed to diagnose and monitor conditions related to abnormal testosterone levels, such as hypogonadism (low testosterone) and hyperandrogenism (high androgen levels). There are several types of testosterone blood tests, each serving a unique purpose. The total testosterone blood test measures the overall amount of testosterone in your blood, including both bound and free testosterone. The free testosterone test measures the testosterone that is not bound to proteins in the blood, making it readily available to the body’s tissues. Additionally, the bioavailable testosterone test measures the testosterone that is available to the body’s tissues and is not bound to sex hormone-binding globulin (SHBG). Understanding these different tests helps in accurately diagnosing and managing conditions related to testosterone levels. Why Monitor Testosterone Levels on TRT? Testosterone replacement therapy (TRT) is a medical treatment designed to increase testosterone levels in individuals with hypogonadism. Monitoring testosterone levels on TRT is essential to ensure the treatment’s effectiveness and safety. Here are some key reasons why monitoring testosterone levels on TRT is crucial: Ensuring Normal Testosterone Levels: The primary goal of TRT is to elevate testosterone levels to within the normal range. Regular monitoring helps ensure that the treatment is effective and that testosterone levels are neither too high nor too low. Adjusting Dosage: Monitoring testosterone levels allows healthcare providers to adjust the TRT dosage as needed, ensuring optimal treatment outcomes. Identifying Side Effects: TRT can cause side effects such as acne, hair loss, and mood changes. Regular monitoring helps healthcare providers identify these side effects early and adjust the treatment plan accordingly. Monitoring Long-term Effects: TRT can have long-term effects on the body, including changes in bone density and cardiovascular health. Regular monitoring helps healthcare providers track these changes and make necessary adjustments to the treatment plan. By keeping a close eye on testosterone levels, healthcare providers can ensure that TRT is both effective and safe for the patient. Hematocrit Test Hematocrit refers to the proportion or percentage of red blood cells present in your total blood volume. Your red blood cells are responsible for transporting oxygen and nutrients throughout your body. Without enough red blood cells (a condition known as anemia), your body suffers from oxygen and nutrient deprivation. On the flip side, too many red blood cells cause high hematocrit that can turn your blood into a thick slurry that can seriously affect your circulation. A normal hematocrit for an adult male is anywhere from 42 to 54%. If your hematocrit results are lower than 41%, it means you have low proportion of red blood cells. Over 55%, and you have too many. One of the primary side effects of TRT is the production of too many red blood cells, leading to high hematocrit. High hematocrit can be lowered by blood donation or therapeutic phlebotomies (ordered by your doctor if you are not allowed to donate blood at a blood bank due to exclusion criteria). Just be careful: Do not donate blood more frequently than every 2 months since this can deplete your iron stores and make you tired. This test is included in CBC (chemistries and blood count) panel.   PSA Test Prostate-specific antigen, or PSA, is a protein that is produced in your prostate gland. It's designed to liquefy semen, which is necessary for the free swimming of sperm in ejaculate. It may also help to dissolve the cervical mucus to allow the sperm to enter the uterus for the purposes of impregnation. Normal PSA levels for men under 40 range between 0 and 2 ng/mL, while PSA levels for men older may raise slowly. A PSA test helps to detect extra-high levels of this protein. High PSA levels are the result of disruptions of the cellular structure of the prostate gland, which can be caused by a number of diseases--including cancer or an infection. Benign prostate hyperplasia, urinary retention, and prostatitis can be the cause of high PSA, but your doctor will want to monitor your PSA levels just to be sure the problem isn't a serious one. If PSA levels are high, your doctor may recommend a prostate exam or even a biopsy to determine the cause of your elevated PSA levels. TRT is contraindicated for men with PSA greater or equal than 4. Estradiol Test Estradiol is the primary female sex hormone, but did you know that the male body produces it from testosterone? It is produced in fat and liver cells from testosterone via the aromatase enzyme. Due to several factors like fat content, liver disease, medication effects and genetics, some men may produce more estradiol from testosterone than other men. New information has shown that men require a special estradiol test called sensitive estradiol test. The regular test used for women may overestimate estradiol in men due to interference of inflammatory markers like C-Reactive Protein (CRP). For the average man, estradiol levels should remain lower than 50 pg/mL, although there is little evidence of what the top of the estradiol test is in men who do not have low testosterone. If estradiol levels are higher than 50 and you start showing symptoms of high estradiol (gland growth under nipples, too much water retention), it may be necessary to take an estrogen blocker (aromatase inhibitor) . However, taking aromatase inhibitor like anastrozole should be done with careful monitoring of sensitive estradiol blood test since overdosing can cause health issues in men. A few of the reported effects of low estradiol levels include: joint pain, eye fatigue, loss of erections, limited sensitivity in the penis, sleepiness, and excessive urination. Long term low estradiol can decrease bone density. A few of the reported effects of high estradiol levels (in the presence of low testosterone) include: soft erections, water retention, excessive sweating, insomnia, bloating, hot flushes, brain fog, and high blood pressure. Blood Pressure The term "blood pressure" refers to the pressure in your arteries during the beating of your heart. There are two numbers: 1) The top number, or systolic, tells you the pressure in your arteries when the muscles of your heart contract. 2) The bottom number, or diastolic, tells you the pressure in your arteries when your heart relaxes and refills with blood in the pause between heartbeats. Healthy blood pressure is lower than 120/80. If your blood pressure rises anywhere from 121/81 to 139/89, you are pre-hypertensive. Crack 140/90, and you suffer from hypertension. Anyone over 180/100 is in serious hypertensive crisis. TRT can increase water retention, sodium uptake and hematocrit is some men, factors that can increase blood pressure. If your blood pressure rises too much, it can place excess strain on your blood vessels and potentially cause a crack. Should the blood vessels crack, the resulting clotting (your body's attempt to stop internal bleeding) can interfere with healthy blood flow--potentially leading to heart attacks, strokes, peripheral arterial disease, and other cardiovascular problems. Estimated Glomerular Filtration Rate eGFR Your glomerular filtration rate (GFR) is an indication of your kidney function. The higher your GFR, the more blood passes through the glomeruli (the filters in your kidneys that remove waste from your blood) every minute. A healthy GFR is anywhere from 90 to 120 mL/min/1.73 m2. Senior citizens will often have lower GFR levels, due to the fact that kidney function decreases with age. Note: It's important to understand that each lab has its own measurements, so what is "healthy" to some may be low with others. If your GFR drops below 60 and remains at that low level for more than 3 months, it's an indication of chronic kidney disease. Liver Enzymes Test Your liver is responsible for a number of important functions, such as breaking down nutrients, producing the proteins that clot your blood, and eliminating toxins. The enzymes produced by your liver are responsible for carrying out these functions. However, if the liver suffers damage, those enzymes tend to leak into your bloodstream. High levels of liver enzymes are a good indicator that your liver has been damaged ALT and AST are the two most common liver enzymes. AST should be anywhere from 10 to 40 units per liter of blood, and ALT should be from 7 to 56 units in every liter of blood. Be aware that exercise may increase these two enzymes in a non-clinically significant way. Only oral testosterone replacement has been shown to increase liver enzymes. TSH Test Thyroid-stimulating hormone, or TSH, is a hormone produced by your pituitary glands in order to stimulate your thyroid gland to produce T3 and T4 hormones. These thyroid hormones play a role in your body's metabolic function. Normal TSH levels should be between 0.5 and 3.5 U/ml (different guidelines show different upper TSH levels). Many educated doctors test for free T3 and free T4 (the unbound thyroid hormones) when TSH is over 3 since they believe this will provide a better picture of thyroid health. If TSH levels are low, it's an indication of hyperthyroidism. If TSH levels are very high, it's an indication of hypothyroidism. Free T3 Test Free T3 refers to unbound T3 (thyroid) hormone in your bloodstream. T3 is the more important of the thyroid hormones, but it can only be produced from T4. This means your body needs to produce T4 then turn it into T3. Once the T3 is unbound from the protein molecules, it can then be used by your body to stimulate metabolic function in all your cells. Normal Free T3 levels are anywhere from 230 to 620 pg/d. If free T3 is low, your doctor may test for thyroid antibodies to ensure that you do not have an autoimmune disease called Hashimoto's. Total Testosterone Test Total testosterone test measures refer to all of the testosterone circulating in your body. Some testosterone circulates freely, while some is bound to protein molecules. The whole point of TRT is to increase your testosterone levels. A normal testosterone range is anywhere from 350 to 1070 ng/dL. Low testosterone can cause low mood, sex drive, fatigue and other symptoms. In some men, too much testosterone in the body can lead to excessive estradiol, acne, oily skin, hair loss, testicular shrinking, and increased blood viscosity due to high red blood cells. Free Testosterone Test Free testosterone refers to the testosterone circulating in your body that is NOT bound to protein molecules like albumin and sex hormone binding globulin. It is believed that your body is more easily able to use free testosterone. It usually runs at about 2 percent or higher of total testosterone. Testosterone Test Results and Interpretation Testosterone test results are typically reported in nanograms per deciliter (ng/dL). The normal range for testosterone levels varies depending on age, sex, and the laboratory performing the test. Here are some general guidelines for interpreting testosterone test results: Normal Testosterone Levels in Adult Men: 300-1,000 ng/dL Normal Testosterone Levels in Adult Women: 15-70 ng/dL Low Testosterone Levels: Less than 300 ng/dL in men or less than 15 ng/dL in women High Testosterone Levels: Greater than 1,000 ng/dL in men or greater than 70 ng/dL in women It’s important to note that testosterone levels can fluctuate throughout the day and may be influenced by various factors such as sleep, stress, and exercise. Therefore, a single testosterone test result may not provide a complete picture of an individual’s overall testosterone levels. Healthcare providers may recommend repeat testing to confirm the results and monitor changes in testosterone levels over time. Understanding your testosterone test results and their implications can help you and your healthcare provider make informed decisions about your treatment plan. Ferritin Test Ferritin is a protein that is responsible for storing iron and releasing it when your body needs to produce red blood cells. If you suffer from an iron deficiency, your ferritin level are likely to be low. Ferritin levels also fall when you give blood (a common method of lowering hematocrit). Normal ferritin levels for men is anywhere from 30 to 300 ng/mL. However, if ferritin levels are too low (after a blood donation), your body is unable to store iron, meaning it will not be able to produce new red blood cells. If you are considering donating blood to lower your hematocrit, it's a good idea to check your ferritin levels first. Your body needs enough of this protein to reproduce the red blood cells you are donating HDL Cholesterol Test High density lipoprotein, also known as HDL cholesterol, is the "good" type of cholesterol. It's responsible for counteracting the effects of low-density lipoprotein, or LDL cholesterol. Low HDL and high LDL may lead to a wide range of cardiovascular problems, including blocked arteries, stroke, heart attack, and peripheral arterial disease. According to experts, even a 5 mg/dL decrease in HDL cholesterol can increase your risk of coronary heart disease by as much as 25% Normal HDL cholesterol levels are anything above 40 mg/dL. Unfortunately, decreased HDL is a known side effect of TRT in some men using higher testosterone doses. Your doctor will monitor HDL cholesterol via a lipid panel in order to ensure that you are not at risk for heart disease. Educate yourself about testosterone replacement side effects 

Vitamin D and testosterone are two of the most important factors in our health but are often overlooked. This post will dive into the complex relationship between vitamin D and testosterone, looking at how deficiency affects our health and the results of The Graz Vitamin-D Randomized Clinical Trial on hormonal balance through a randomized controlled trial. We’ll look at several studies that have investigated the correlation between 25(OH)D deficiency and sex hormones. And we’ll see how vitamin D supplementation can affect hormonal balance by looking at the results of The Graz Vitamin-D Randomized Clinical Trial. We’ll also look at how much testosterone the testicular tissue can produce with different amounts of vitamin D and how blood levels of testosterone and vitamin D are related. And we’ll touch on symptoms of low testosterone and why it’s important to understand your Vitamin D status & hormonal balance for optimal health. Introduction and Background on Vitamin D and Testosterone Vitamin D and testosterone are two of the most important nutrients in our bodies and overall health. Vitamin D is a fat soluble vitamin that is important for bone health, immune function and reproductive health. It regulates calcium and phosphate metabolism so bones stay strong and healthy. Testosterone is a steroid hormone produced in the testes in men. It’s responsible for male characteristics like facial hair, deep voice and muscle mass. Research shows a complex relationship between vitamin D and testosterone in men. Studies show that vitamin D deficiency is linked to low testosterone which can cause various health issues. Understanding this relationship is important for optimal health outcomes especially for men who are experiencing symptoms of low testosterone. What is Vitamin D’s Role in the Body Vitamin D is an essential nutrient that plays a big role in bone health, immune function and reproductive health. It regulates calcium and phosphate metabolism which are needed for strong bones and teeth. Vitamin D also supports the immune system to fight off infections and diseases. We get vitamin D from sun exposure, diet and supplements. But many are deficient in vitamin D especially during winter when sun is scarce. Deficiency can cause various health problems like weak bones, increased susceptibility to infections and impaired immune function. Having adequate vitamin D levels is important for overall health and well-being. Low Testosterone and Vitamin D Deficiency Obesity is linked to low serum 25-hydroxyvitamin D (25(OH)D) levels which in turn is associated with testosterone deficiency and low testosterone in young men. Hypovitaminosis of vitamin D can cause long term health problems like drop in testosterone production and higher risk of hypogonadism. In this section we’ll discuss what causes low testosterone and lack of vitamin D and how these two affects each other. Causes of Low Testosterone and Vitamin D Deficiency Poor diet: A diet lacking in essential nutrients like vitamin-D rich foods such as fatty fish, fortified dairy products and egg yolks can cause deficiency. Those deficient in vitamin D may benefit from taking the right vitamin D supplement to address low testosterone. Lack of sun exposure: Since our bodies synthesize vitamin D through sun exposure on our skin, not spending enough time outdoors or living at higher latitudes can cause deficiency. Obesity: Excess body fat can disrupt hormone regulation and absorption/utilization of vitamins like vitamin D (source). This creates a vicious cycle where obesity causes low testosterone and worsen existing deficiency. Aging: As men age, their natural ability to produce hormones like testosterone decreases. Older adults have lower 25(OH)D levels partly because they spend less time outdoors exposed to direct sunlight (source). How Low Testosterone and Vitamin D Deficiency Affects Health The interplay of low testosterone and vitamin D deficiency can cause: Hypogonadism: A condition where the testes produce less or no hormones leading to symptoms like fatigue, decreased muscle mass and sexual dysfunction. Osteoporosis: Both testosterone and vitamin D are important for bone density. Low levels of either nutrient can increase risk of osteoporosis (source). Mood disorders: Studies show that there is a link between low testosterone/vitamin D deficiency and higher prevalence of depression and anxiety (source). Cardiovascular disease: Research shows that men with lower levels of both hormones are at higher risk of cardiovascular events like heart attacks or strokes (source). Given these health effects, it’s more important to know how obesity affects this interaction and how to balance our hormones as a whole. Low testosterone and not enough vitamin D go together to create health problems so it’s clear there’s a strong connection between the two. We need to look into the studies on how vitamin D affects serum testosterone levels to understand more about these associations. Summary: This article discusses the connection between low testosterone and vitamin D deficiency and their health effects. It’s clear that obesity plays a big role in the hormone relationship so understanding how these two work together is key to overall health. Vitamin D and Testosterone Levels Research In the recent years, many studies have been done to look into the relationship between vitamin D status and hormone balance especially on free bioavailable testosterone levels and testosterone production. Some studies show positive association between 25(OH)D levels and total/free testosterone levels while others found no significant relationship for certain hormonal parameters. Studies on 25(OH)D deficiency and sex hormones A study in Clinical Endocrinology (Oxf) found that men with sufficient vitamin D had higher total testosterone (TT), free testosterone (FT) and bioavailable testosterone compared to those with insufficient or deficient vitamin D. The researchers concluded that there is a strong relationship between 25(OH)D and TT/FT levels. A study in The Journal of Clinical Endocrinology & Metabolism found that low 25(OH)D was associated with hypogonadism in middle aged men but not with changes in luteinizing hormone (LH). A more recent study in Andrology however found no significant correlation between 25(OH)D levels and various hormonal parameters like LH, FSH and inhibin B in healthy young men. The studies show the complex relationship between vitamin D and testosterone production. We need to consider that age, ethnicity, BMI and overall health can affect 25(OH)D levels and hormonal balance in men. A strong connection between 25(OH)D deficiency and sex hormones has been shown in Vitamin D and testosterone studies where testosterone levels were measured in nmol/L. We will now look into the effect of vitamin D supplementation on hormonal balance by examining the results of the Graz Vitamin D Randomized Clinical Trial. Vitamin-D Supplementation and Hormonal Balance One of the studies that looked into the relationship between vitamin D supplementation and hormonal balance is the Graz Vitamin-D Randomized Clinical Trial. The objective of this study was to compare the effects of taking vitamin D for 12 weeks to taking a placebo. The study showed significant differences between the vitamin D group and the placebo group in insulin resistance, hormone levels and other metabolic parameters. Some of the findings on how vitamin D affects testosterone and other metabolic parameters were quite interesting. Graz Vitamin-D Randomized Clinical Trial Results Improved Metabolic Parameters: Those who took vitamin D supplements had reduced insulin resistance which is key to overall health and preventing chronic diseases like type 2 diabetes. Influence on Estradiol Levels: The supplemented group had increased estradiol levels which is one of the main female sex hormones. The supplemented group’s increase in estradiol levels was not statistically significant compared to the placebo group. No Significant Effect on Total Testosterone (TT) Levels: Surprisingly, there was no difference in TT levels between those who took vitamin D supplements and those who did not. This means that while there may be a relationship between blood testosterone levels and vitamin D, supplementation may not have a significant impact on hormone production or regulation for everyone. This study shows the complexity of hormonal balance in our body. Although it’s clear that getting the right nutrients like vitamin D is important for overall health, more research is needed to understand how they affect testosterone production. Those who want to optimize their hormone levels through diet or supplements should consult a healthcare professional and stay updated with the latest research. The Graz Vitamin-D Randomized Clinical Trial results showed that taking vitamin D supplementation had a positive effect on hormonal balance. More research is needed to find out how hCG injections will affect men with different vitamin D levels and how there is a link between testosterone and vitamin D. More well-designed randomized controlled trials are needed to clarify these relationships. Conclusion: So vitamin D supplementation may not affect testosterone levels but it seems to affect metabolic parameters and estradiol levels. More research is needed on how nutrients like vitamin D can alter or control hormone production so consult a specialist before starting any diet or supplementation program. Testosterone and Vitamin-D A study from Rigshospitalet found a relationship between testosterone, sex hormone-binding globulin (SHBG) and vitamin D in 300 healthy men with normal testosterone production. This shows the importance of having adequate vitamin D for hormonal balance. Vitamin-D and Testicular Tissue’s Ability to Produce Testosterone Vitamin D is involved in many physiological processes including sex steroid production. In testicular tissue, it was found that low vitamin D can impair the ability to produce testosterone. Men with low vitamin D had less response to hCG injections compared to those with normal or high vitamin D levels. The studies included in this review were selected based on strict inclusion and exclusion criteria to ensure the integrity and quality of the review process. hCG Injections on Men With Different Vitamin-D Levels Serum Levels: Those with higher 25(OH)D serum levels had increased total testosterone after hCG injections compared to those with lower 25(OH)D serum levels. Luteinizing Hormone (LH): Response rate was also seen for luteinizing hormone which is responsible for stimulating testosterone production in the testicles. Follicle-Stimulating Hormone (FSH): No significant difference was seen in FSH response between the groups based on their initial 25(OH)D levels. So there may be a link between testosterone and vitamin D but more research is needed to understand the implications. For overall health and wellness men should have healthy levels of both hormones. Vitamin D is involved in testosterone production and regulation so let’s think about what this hormonal balance means to a person’s overall health. Conclusion: The study showed a positive correlation between testosterone and vitamin D, higher 25(OH)D resulted to higher total testosterone, LH response was also better when 25(OH)D was normal or high. The study suggests there may be a link between the two which is important for men’s health. Testosterone Production, Regulation and Health Testosterone deficiency which has many health implications is produced in the testes and regulated by hormones like LH. It’s produced in the testicles and regulated by pituitary hormones like luteinizing hormone (LH). Low testosterone can have many negative effects on overall health. In this section we will discuss some of the common symptoms of low testosterone and why we need to understand Vitamin D status & hormonal balance. Symptoms of Low Testosterone Fatigue: One of the most obvious symptoms of low testosterone is fatigue or lack of energy. Men may find it hard to be active or finish their daily tasks due to low energy. Muscle loss: Testosterone is involved in muscle mass so deficiency leads to loss of muscle strength and size. Low libido: Decrease in libido or sex drive often accompanies low testosterone. This may also result to erectile dysfunction in men. Bone problems: Testosterone regulates bone density so deficiency can increase risk of osteoporosis and fractures. Mood changes: Men with low testosterone may experience mood swings, irritability, depression or anxiety as their hormonal balance gets disrupted. li> Why We Need To Understand Vitamin-D Status & Hormonal Balance Vitamin D affects many physiological processes in our body including sex hormones like testosterone. As mentioned earlier studies showed a link between blood testosterone and vitamin D in healthy men with normal testosterone production. So maintaining optimal vitamin D levels may be important for hormonal balance. But more research is needed to understand how these two work together in the body’s endocrine system. In the meantime men who are experiencing symptoms of low testosterone should consult their doctor for proper diagnosis and treatment that can improve both hormone levels and overall health. Conclusion: This article discusses the link between Vitamin D and testosterone, the implications for men who are experiencing low energy or muscle loss. It discusses the common symptoms of low testosterone like low energy and muscle loss, bone problems and mood changes. And how maintaining optimal vitamin D levels can help preserve hormonal balance in men experiencing these symptoms. Vitamin D and Testosterone in Women Vitamin D and testosterone are often linked to men’s health but they also play a big role in women’s health. Vitamin D is important for bone health and immune function in women. It is also involved in the regulation of reproductive hormones for proper menstrual cycles and fertility. Testosterone although present in smaller amounts in women is involved in the development of female characteristics like libido and muscle mass. Having adequate levels of both vitamin D and testosterone is important for women’s overall health. Vitamin D deficiency can cause many health problems like osteoporosis, autoimmune diseases and certain cancers. Low testosterone can affect libido, muscle mass and overall energy. Understanding the roles of these nutrients in women’s health is important to prevent and manage these conditions. Why Vitamin D is important for Women’s Health Vitamin D is important for bone health and immune function in women. It regulates calcium and phosphate metabolism so bones are strong and healthy. It also supports the immune system to fight off infections and diseases. It is also involved in the regulation of reproductive hormones for proper menstrual cycles and fertility. Vitamin D deficiency has been linked to many health problems in women like osteoporosis, autoimmune diseases and certain cancers. Having adequate vitamin D is important to prevent these conditions and overall health. Women should get enough vitamin D through sunlight, dietary sources and supplements if needed. Regular check-ups and blood tests can monitor vitamin D levels and ensure optimal health. FAQs about Vitamin D and Testosterone Does vitamin D increase testosterone? There is some evidence that vitamin D may have a positive effect on testosterone. Studies show that taking vitamin D supplements can increase testosterone especially in men who are deficient. But more studies are needed to determine the ideal dosage and if other factors affect this relationship. To get the most out of vitamin D supplements for testosterone, you should also change your lifestyle like exercise more and eat better. How much vitamin D for testosterone? Vitamin D is important for testosterone production. Studies show that men with higher vitamin D levels have higher testosterone than those with lower levels. For optimal testosterone production daily vitamin D intake should be between 600-1000 IU but higher doses may be needed in some cases. If you are unsure of your current vitamin D status or how much to supplement, consult a doctor before taking any supplements. Conclusion In summary, we need to understand the connection between vitamin D and testosterone. Low levels of either can cause health problems like low energy or libido, depression and even increase risk of certain diseases. To keep you healthy you should eat a balanced diet with vitamin D rich foods (like fish) and exercise regularly. Supplement may be needed if your blood tests show you have low levels of these nutrients. Proper care can provide our body with the necessary vitamin D and testosterone for optimal health. Check your Vitamin D and Testosterone levels with Discounted Labs. Get your Vitamin D and Testosterone test today without doctor’s visit!   References Effect of Vitamin D Supplementation on Testosterone Levels in Men Association Between Vitamin D Deficiency and Testosterone Levels in Adult Males: A Systematic Review Can Vitamin D Restore Low Testosterone Levels? Vitamin D Increases Testosterone Production Can Vitamin D Increase Testosterone Concentrations in Men? 25-Hydroxyvitamin D and Testosterone Levels Association Through Body Mass Index: A Cross-Sectional Study of Young Men with Obesity Effect of Vitamin D Supplementation on Testosterone Levels in Men