Page 5 - Testosterone Tests

What Are the Symptoms of Low Testosterone (Deficiency)? Hypogonadism is the medical term for a male condition caused by the body not producing sufficient amounts of testosterone. Most people don’t realize that, in addition to sexual desire, testosterone also affects lean body mass, strength, bone density, mental focus, mood, fat loss, and other essential factors in both males and females. Common complaints for men with hypogonadism include lower sexual desire (libido), erectile dysfunction (softer erections or lack of erections), depression, low energy and appetite, changes in body composition (lower lean body mass and higher abdominal fat), lower strength, reductions in body and facial hair, less mental focus, decreased height, and osteoporosis (decrease in bone density). A list shows that normalizing testosterone in people with lower-than-normal levels has dramatic benefits, including increased sexual desire, lean body mass, bone density, strength, mood, motivation, mental focus, and stamina. However, these benefits can be erased if proper monitoring, dose adjustment, and an appropriate choice of testosterone replacement option are not accomplished. Benefits of Normalizing Testosterone Restored sexual desire Improved erectile function Improved mood or sense of wellbeing Increased lean body mass, strength, and stamina Improved bone density Decreased fat mass Determining If You Have Testosterone Deficiency In addition to blood tests and physical examinations, researchers at St. Louis University have also developed a brief screening instrument to aid in diagnosing hypogonadism. Known as the Androgen Deficiency in the Aging Male (ADAM) Questionnaire: Do you have a decrease in sex drive? Do you lack energy? Have you experienced a decrease in strength and endurance? Do you feel shorter? Have you lost height? (Lower bone density can decrease size.) Have you noticed a decreased enjoyment of life? Are you sad and grumpy? Are your erections less strong or gone? Has it been more challenging to maintain your erection throughout sexual intercourse? Are you falling asleep after dinner? Has your work performance deteriorated recently?   Other questions that are usually not asked by doctors but which I’ve found to be important are the following:   Are you relating well to the people around you? • Are you able to pay attention when someone talks to you? • Are you loving your lover or life partner? Are you able to pay attention when someone talks to you? Several of the abovementioned problems can be caused by many other issues unrelated to low testosterone. Depression, anxiety, stress, medications, and sleep disorders can cause nine of those ten symptoms (a decrease in height would be the only item unrelated to bone loss or back surgery). This questionnaire is not a perfect predictor of low testosterone and should not replace tests for testosterone blood levels. The benefit of this questionnaire is that it may encourage some men to seek medical advice.  Then they can get their testosterone checked and have a physical examination to help determine whether they are indeed hypogonadal. Causes of Testosterone Deficiency Hypogonadism is caused when the testicles fail to produce normal levels of testosterone. Testosterone levels are low in one type of hypogonadism, while LH and FSH are elevated. In another, there is not enough secretion of LH and FSH needed to tell the testicles to produce the required testosterone. Some commonly used medications, such as Megace (an appetite stimulant), Nizoral (an anti-fungal agent), Prednisone (an anti-inflammatory corticosteroid), and Tagamet (an antacid), can also lower testosterone production. Illness and aging can cause a decrease in testosterone and an increase in sex hormone-binding globulin (SHBG). Furthermore, high prolactin hormone levels may suggest a pituitary tumor, causing a decline in testosterone production. It is essential that your doctor measure hormones in the HPGA cascade to diagnose what kind of hypogonadism you have. The most common type of hypogonadism presents low testosterone with normal or elevated FSH and LH levels, which indicates that your testicles are not responding to the signals of both LH and FSH. This is what is called primary hypogonadism.   There are several reasons why testosterone levels may be low: SHBG is binding too much free testosterone. This would be especially apparent if a male’s total testosterone level is in the high reference range but his free testosterone (unbound) level is low. As previously mentioned, aging and illness increase SHBG. The pituitary gland, which controls testosterone production through the production of LH, is not secreting enough LH to stimulate the production of testosterone by the testicles. In this case, total testosterone would be low. The hypothalamus is not functioning correctly. LH levels of less than two ng/mL suggest a lesion in this part of the HPGA. The testicles have lost their ability to produce testosterone, despite adequate LH. In this case, the level of LH would be high (greater than ten ng/mL) despite a low testosterone level. Dehydroepiandrosterone (DHEA) levels are abnormally low. DHEA is a hormone produced by the adrenal glands that has many of the same benefits as testosterone. It is also a precursor to testosterone in women. Disease or infection. Street drugs, prescription or over-the-counter medications (more on this later) Lab error. High prolactin levels may indicate the presence of a pituitary tumor that impairs the production of hormones that tell your testicles to produce testosterone (rare condition but worth mentioning!) Defects in genes that affect LH and FSH production. Buy Testosterone Lab Tests on DiscountedLabs.com    

What are the common symptoms of gynecomastia? Common symptoms of gynecomastia include breast swelling and tenderness, nipple discharge, and breast enlargement. It is important to note that gynecomastia may occur on one or both sides of the chest and can affect males of all ages, from infants to older adults. What is Gynecomastia and How to Diagnose it   Gynecomastia is a benign enlargement of the male breast resulting from a growth of the glandular tissue of the breast, known as male breast tissue. It is defined clinically by the presence of a rubbery or firm mass extending concentrically from the nipples. At least 30% of males, including older men, will be affected during their life. Since it causes anxiety, psychosocial discomfort, and fear of breast cancer, early diagnostic evaluation of male breast tissue enlargement is important, and patients usually seek medical attention. Evaluation of gynecomastia must include a detailed medical history, clinical examination, specific blood tests, imaging, and tissue sampling. Individual treatment requirements can range from simple reassurance to medical treatment or even surgery. Men who start experiencing this problem complain of pain and tenderness around the nipple area. Gynecomastia was reported to cause an imbalance between estrogen and androgen action or an increased estrogen to androgen ratio, due to increased estrogen production, decreased androgen production or both, which can lead to a decrease in the level of testosterone compared with the level of estrogen. As men get older, they produce less testosterone. Older men also tend to have more body fat, and this can cause more oestrogen to be produced. These changes in hormone levels can lead to excess breast tissue growth. Androgens include testosterone and DHT. High estradiol in the presence of low testosterone and DHT, growth hormone (IGF-1 is a metabolite), and a genetic predisposition to gynecomastia can increase the size of breast tissue in men. Additionally, the lowered testosterone can cause the breast glands to enlarge and the weight gain means fatty tissue accumulates under the breast, leaving the man with a larger quantity of glandular tissue and more fat in the breast. As fat cells are estrogenic, this additional fat can further disrupt the balance between testosterone and estrogen. Gynecomastia Causes Physiological gynecomastia, also known as physiologic gynecomastia, is common in pubertal boys and appears to be associated with increased hormone levels of insulin-like growth factor-1 (IGF-1) and pubertal growth, but not with a shift in the balance between estrogen and testosterone, a new study suggests. Study authors noted that IGF-1 together with estrogen is essential for the growth of breast tissue, and it appears that the effect of growth hormone on breast growth is mediated through IGF-1. "The stimulatory effect of IGF-1 on breast formation was synergized by estradiol, which was also elevated in boys with physiologic gynecomastia in our study. However, serum testosterone was similarly elevated, leaving the estradiol/testosterone ratio unaltered." Prolactin, another anterior pituitary hormone integral to breast development, is not only secreted by the pituitary gland but may also be produced by normal mammary tissue epithelial cells and breast tumors (14, 15). Testosterone converts into estradiol, DHT, and other metabolites. Men with higher amounts of the enzyme aromatase usually have this problem even at lower doses of testosterone. The growth of this glandular tissue is also influenced by a higher fat percentage, older age, excessive alcohol intake, and the use of certain medications. Gynecomastia rarely occurs in men using testosterone replacement since testosterone to estradiol ratios are improved. Estrogen levels that are too high or are out of balance with testosterone levels can cause liver disease and gynecomastia. In several studies on testosterone replacement, only a very small percentage of people receiving testosterone experience growth of breast tissue. In one HIV-specific study conducted by Dr. Judith Rabkin in New York, she reported that out of 150 men enrolled in the study, two men experienced this adverse reaction. Dihydrotestosterone (DHT) is a natural metabolite of testosterone that has antiestrogen activity and cannot be converted into estradiol at the tissue level. Systemic or locally administered DHT has been successfully prescribed for the treatment of patients with idiopathic and estrogen-induced gynecomastia. Gynecomastia is also seen in men with androgen resistance with low testosterone production and DHT, where unfettered estrogen can stimulate subsequent breast development. However, in men with normal androgen receptor activity, estradiol is unable to stimulate breast development. This is thought to be due to an imbalance between the inhibitory and stimulatory effect of these hormones. Gynecomastia may be caused by abnormal hormone changes, any condition that leads to an increase in the ratio of estrogens/androgens such as liver disease, kidney failure, thyroid disease, and some non-breast tumors. Certain health conditions, like hypogonadism, can either cause or be linked with gynecomastia. Click: Buy gynecomastia blood test panel   Gynecomastia Symptoms Gynecomastia is a condition that causes the breast tissue in males to swell and become larger than usual. The primary symptom of gynecomastia is noticeable breast enlargement in men, which can be unilateral or bilateral. Other symptoms include tenderness or pain around the nipple area, swelling or lumps in the breast tissue, and changes in breast shape or texture. In some cases, one of the gynecomastia symptoms may also be the discharge from the nipples. If you experience any of these symptoms, it's essential to consult with a doctor to determine the underlying cause and explore treatment options. Medications and Products That Can Cause Gynecomastia Some medications have been reported in the medical literature to cause gynecomastia due to decreases in testosterone, increases in estradiol, or both. These include: · Antiandrogens.  · HIV medications.  · Anti-anxiety medications. · Tricyclic antidepressants.  · Glucocorticoid steroids. · Antibiotics. · Ulcer medication such as cimetidine . · Cancer treatment (chemotherapy). · Heart medications such as digitalis and calcium channel blockers. · Anabolic steroids · Soy and flaxseed · Exposure to pesticides and byproducts of plastic processing has also been linked to increased estrogen and decreased sperm count in men. If the cases of gynecomastia are drug-induced, gynecomastia symptoms like decreased tenderness and softening of the glandular tissue will usually be apparent within one month after discontinuation of the drug. However, if the cases of gynecomastia have been present for more than one year, it is unlikely to regress substantially, either spontaneously or with medical therapy, because of the presence of fibrosis. In such circumstances, surgical subcutaneous mastectomy, ultrasound-assisted liposuction, and suction-assisted lipectomy, including gynecomastia surgery options like liposuction, are the best options for cosmetic improvement, as described in several case series. If symptoms persist after two years or past 17 years of age, further evaluation is indicated. During the rapid, proliferative phase, manifested clinically as breast pain and tenderness, medical therapy may be attempted. Most studies of drugs -- including testosterone (in patients without hypogonadism), have been uncontrolled and thus difficult to interpret because gynecomastia may resolve spontaneously. The few randomized, double-blind, placebo-controlled trials generally have been limited by small samples and do not disclose the potential side effects. Gynecomastia Treatments: Although not approved for the treatment of gynecomastia, the selective estrogen-receptor modulator tamoxifen, administered orally at a dose of 20 mg daily for up to 3 months, has been shown to be effective in randomized and nonrandomized trials, resulting in partial regression of gynecomastia symptoms in approximately 80% of patients and complete regression in about 60%. Patients in whom tamoxifen is effective usually experience a decrease in pain and tenderness within one month. In a retrospective analysis of a series of patients with idiopathic gynecomastia, 78% of patients treated with tamoxifen had complete resolution of gynecomastia, as compared with only 40% of patients receiving danazol. In case series describing the use of tamoxifen for this condition in more than 225 patients, adverse events were uncommon but can include body aches, low sex drive, and fatigue. In a double-blind study of 282 men randomized to receive 20 mg of tamoxifen once per day with bicalutamide or bicalutamide alone found that after six months, gynecomastia and breast pain were significantly reduced in men who received tamoxifen (88 versus 96 percent in the control group). The aromatase inhibitor anastrozole was not shown to be more effective than placebo in a randomized, double-blind, placebo-controlled trial in boys with pubertal gynecomastia. Although in an uncontrolled study of 10 patients with pubertal gynecomastia, the selective estrogen-receptor modulator raloxifene was shown to result in more than a 50% decrease in the size of the gynecomastia in the majority of the boys, there are insufficient data to recommend its use at this time. Lowering the testosterone dose had not proven helpful for the two patients in Dr. Rabkin's study. The use of antiestrogens, such as tamoxifen 10 mg twice daily, with lower doses of testosterone have been effective. Some physicians prescribe low dose aromatase inhibitors for men with early-onset gynecomastia. Gynecomastia can become permanent if the condition lasts very long although it may reduce in size when the androgen use is discontinued. In rare cases, surgical correction may be necessary in severe cases. For men who experience enlarged breast size, doctors usually check estradiol levels to determine whether too much testosterone is being converted into estrogen. However, physicians usually forget that other hormone metabolites like DHT and IGF-1 may be involved in the development of gynecomastia, so they do not include these tests in the diagnostics panel. In order to properly diagnose gynecomastia, your healthcare provider will take your past health and medicine history and give you a physical exam. A blood test may also be recommended to check hormone levels. In some cases, a biopsy may be performed to examine the breast tissue for cancer cells, especially if there are any breast abnormalities detected during a mammogram. Warning: Bringing estrogen down to very low levels could cause health problems in men in the long run. Hair/skin quality and health, brain function, bone density, lipids, sexual function, and other important factors may be greatly influenced by estrogen. More information about estradiol and gynecomastia. Bibliography: Braunstein, G. D., M.D. (2007). Gynecomastia. The New England Journal of Medicine, 357(12), 1229-123712 Schulster M, Bernie AM, Ramasamy R. The role of estradiol in male reproductive function. Asian J Androl 2016;18:435-4034

Embarking on the path of Testosterone Replacement Therapy (TRT) often evokes a blend of enthusiasm and concern among men. The allure of renewed vigor, heightened sexual desire, and robust muscle growth is enticing. However, there are a lot of less well-known aspects that your healthcare provider might not immediately disclose. For instance, were you aware that TRT could affect your fertility or exacerbate your sleep apnea? While TRT heralds a new dawn for many, it doesn’t offer a universal remedy. In light of this, we have meticulously curated a comprehensive list of 18 pivotal aspects that might elude your doctor's attention but are indispensable for you to grasp. Venture further to unearth the profundities of TRT. Low Blood Levels of Testosterone and Associated Risks: < 450 ng/dl (15.3 nmol/l) - Risk of metabolic syndrome Reference: Dhindsa, S., Miller, M. G., McWhirter, C. L., Mager, D. E., Ghanim, H., Chaudhuri, A., & Dandona, P. (2010). Testosterone concentrations in diabetic and nondiabetic obese men. Diabetes Care, 33(6), 1186-1192. PubMed < 400 ng/dl (15.3 nmol/l) - Venous leakage (internal penile damage) risk Reference: Yassin, A. A., & Saad, F. (2017). Testosterone Deficiency and Testosterone Treatment in Older Men. Gerontology, 63(2), 144–156. PubMed < 350 ng/dl (11.9 nmol/l) – All-cause death risk and anemia risk Reference: Khaw, K. T., Dowsett, M., Folkerd, E., Bingham, S., Wareham, N., Luben, R., ... & Day, N. (2007). Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men. Circulation, 116(23), 2694-2701. PubMed < 300 ng/dL (10.2 nmol/L) - Lowered libido, weight gain & Diabetes risk increased Reference: Traish, A. M., Saad, F., & Guay, A. (2009). The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction Journal of Andrology, 30(1), 10-22. PubMed < 300 ng/dL (10.2 nmol/L): Quartile risk of fractures (osteoporosis), memory-related issues and depression risk increases Reference: Orwoll, E., Lambert, L. C., Marshall, L. M., Phipps, K., Blank, J., Barrett-Connor, E.,... & Cummings, S. (2006). Testosterone and estradiol are common among older men. The Journal of Clinical Endocrinology & Metabolism, 91(4), 1336-1344. PubMed < 250 ng/dl (8.5 nmol/l): Arterial plaque (arteriosclerosis) & sleep quality affected Reference: Vlachopoulos, C., Ioakeimidis, N., Miner, M., & Aggelis, A. (2014). Testosterone deficiency: a determinant of aortic stiffness in men Atherosclerosis, 233(1), 278-283. PubMed < 235 ng/dl (8.0 nmol/l) hardening of arteries (dialysis patients) Reference: Carrero, J. J., Qureshi, A. R., Parini, P., Arver, S., Lindholm, B., Bárány, P., ... & Stenvinkel, P. (2009). Low serum testosterone increases mortality risk among male dialysis patients. Journal of the American Society of Nephrology, 20(3), 613-620. PubMed < 200 ng/dl (6.8 nmol/l) morning erections decrease Reference: O'Connor, D. B., Lee, D. M., Corona, G., Forti, G., Tajar, A., O'Neill, T. W., ... & EMAS Study Group. (2011). The relationships between sex hormones and sexual function in middle-aged and older European men. The Journal of Clinical Endocrinology & Metabolism, 96(10), E1577-E1587. PubMed < 150 ng/dl (5.1 nmol/l) - Increased inflammation (TNF-alpha) Reference: Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004). The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. The Journal of Clinical Endocrinology & Metabolism, 89(7), 3313-3318. PubMed The Unspoken Implications of TRT Your doctor might overlook mentioning certain ramifications when you commence Testosterone Replacement Therapy (TRT): Fertility and TRT Sperm Count Drop: TRT lowers the levels of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), two hormones that help make sperm. If preserving fertility is a priority, discuss with your healthcare provider incorporating Clomiphene or hCG into your TRT regimen. Hematological Effects Blood Viscosity Increase: TRT can escalate your blood's hematocrit level, thereby increasing its viscosity. Although some practitioners may advise halting TRT, this side effect can be managed adeptly through blood donations or therapeutic phlebotomy. Beware; frequent blood donations might deplete iron levels and induce fatigue. Impact on Natural Testosterone Production Suppression of Endogenous Testosterone: TRT suppresses your body’s natural testosterone synthesis, which may rebound anywhere between a few weeks and six months post-cessation. The Multifaceted Benefits and Varied Efficacy of TRT Muscle Mass, Fat Reduction, and Sexual Health Sex Drive and Physique Enhancement: TRT predominantly augments libido, muscle mass, and fat metabolism in men. However, its effectiveness varies, and meticulous dosage and frequency adjustments along with side effect management are imperative. It’s not a panacea. Administration Techniques Methods of Injection: Contrary to what most people think, testosterone can be injected superficially (IM) or deeply (subcutaneously) into the muscle using a 1/2-inch, 27-29-gauge insulin syringe. Topical Testosterone Efficacy of Gels and Creams: Testosterone gels and creams are efficacious but often under-dosed by physicians. More concentrated compounded products or dosage adjustments based on blood levels can rectify this. Dosage Frequency Optimized Injection Schedules: Shifting from biweekly 200mg injections to weekly 100mg or twice-weekly 50mg dosages can often yield better results. Addressing Concerns and Optimizing TRT Outcomes Sleep Apnea and TRT Sleep Apnea Dynamics: TRT could exacerbate central sleep apnea but might alleviate obstructive sleep apnea over time as weight loss occurs. Erectile Function Erectile Function and Libido: TRT enhances erectile function and libido in a majority of men. Some may benefit from adjunctive low-dose daily Cialis, which also harbors cardiovascular advantages. Self-Monitoring and Telemedicine Monitoring Blood Tests: Companies like DiscountedLabs.com enable self-monitoring of blood tests without a doctor visit. Moreover, telemedicine facilitates access to testosterone doctors nationwide, albeit mostly without insurance coverage. Debunking Misconceptions and Enhancing TRT Knowledge Prostate Health and Cardiovascular Effects Prostate Cancer and Heart Attacks: Contemporary evidence refutes the notion that TRT triggers prostate cancer or heart attacks, though vigilant monitoring is crucial for optimal cardiovascular outcomes. Community Support and Knowledge Sharing Leveraging Online Communities: Engage with seasoned TRT users on platforms like the ExcelMale forum or Testosterone Replacement Discussion Facebook group to broaden your understanding. Comprehensive Testing Holistic Blood Analysis: Ensure your doctor conducts a thorough blood analysis encompassing total and free testosterone, DHT, thyroid function, and prolactin (especially for those with extremely low T levels) to rule out pituitary adenomas. Insurance, Professional Expertise, and Addressing Common Hurdles Insurance and TRT Insurance Coverage: Insurance coverage for TRT products is often restrictive, but utilizing a compounding pharmacy can be a viable alternative. Expertise in TRT Management Urologists Leading the Charge: The burgeoning expertise of urologists in TRT management is notable, with extensive TRT-centric discussions now a staple at urology conferences. Identifying and Addressing Co-morbidities Co-morbid Conditions: Men with co-existing health issues may encounter challenges in reaping TRT benefits, warranting a thorough cardiovascular assessment for those experiencing water retention and hypertension. Estradiol Management Misconceptions About Estradiol: People often get the wrong idea about this hormone, which plays a big part in libido, bone health, and brain function, because it is not given enough attention when it comes to management. Emerging evidence suggests aromatase inhibition might be unnecessary in TRT management. Armed with this extensive knowledge, you’re now better positioned to make informed decisions on your TRT journey. Remember, individualized consultation with healthcare professionals is indispensable for optimizing your TRT experience.    

Starting Testosterone Replacement Therapy (TRT) is a significant decision that can have a profound impact on your health and well-being. While it offers numerous benefits, like enhanced mood, improved sexual performance, and increased muscle mass, there are also potential side effects and nuances that your healthcare provider might not fully explain. Below, we delve into critical aspects of TRT that every man should be aware of. But first, did you know that you can easily and affordably monitor your testosterone levels through DiscountedLabs.com? It's an excellent way to keep track of your health without the hassle of a doctor's visit. Table of Contents Impact on Sperm Count How TRT Affects Your Fertility Blood Viscosity and Hematocrit Managing Increased Red Blood Cells Shutdown of Natural Testosterone Production Recovery Post TRT Dose and Effectiveness TRT is Not a Magic Bullet Different Injection Methods Subcutaneous vs. Intramuscular Testosterone Gels and Creams Topical TRT: Right Dose, Right Results Optimal Injection Frequency The Shift Towards Frequent Dosing Sleep Apnea TRT and Sleep Quality Erectile Function and Libido The Added Benefits and Limitations Monitoring Your Blood Tests Taking Charge of Your Health Telemedicine for TRT Access to Expertise Prostate Cancer and Heart Attacks Debunking the Myths Community Support You're Not Alone Important Blood Tests Beyond Total Testosterone Insurance Limitations Navigating the System Consult a Urologist The Go-To Experts on TRT Comorbidities Risks and Workarounds The Estradiol Obsession Re-Thinking Estradiol Management Impact on Sperm Count How TRT Affects Your Fertility One aspect of TRT that is often overlooked is its effect on fertility. TRT reduces levels of LH (Luteinizing Hormone) and FSH (Follicle Stimulating Hormone), which are crucial for sperm production. If you plan on having children, it's essential to discuss fertility preservation options with your healthcare provider. Treatments like clomiphene or the addition of hCG can be useful. Blood Viscosity and Hematocrit Managing Increased Red Blood Cells TRT may lead to an increase in hematocrit, or the amount of red blood cells in your blood, thereby making it thicker. While some doctors may suggest pausing TRT, this condition can be managed through blood donations or therapeutic phlebotomy. However, frequent blood donations can lead to iron depletion and fatigue. Learn more about managing high hematocrit here. Shutdown of Natural Testosterone Production Recovery Post TRT Once you're on TRT, your natural testosterone production will decline. Usually, your body can recover its testosterone levels within a few weeks to six months after stopping TRT, but it's essential to know that this therapy isn't a temporary commitment. Dose and Effectiveness TRT is Not a Magic Bullet Though TRT can dramatically improve quality of life by enhancing sex drive, muscle mass, and fat loss, the effectiveness varies from person to person. Factors like dose, frequency, and side effect management play a crucial role. Learn about the average time to see benefits. Different Injection Methods Subcutaneous vs. Intramuscular There's a common misconception that testosterone must be injected deep into the muscle. However, you can also use a 1/2 inch 27-29 gauge insulin syringe for subcutaneous injections. Read more about injection methods here. Testosterone Gels and Creams Topical TRT: Right Dose, Right Results Gels and creams offer a less invasive way to administer testosterone, but the effectiveness depends on the right dose and concentration. Doctors often miss this, so make sure you monitor your levels closely. Optimal Injection Frequency The Shift Towards Frequent Dosing Traditionally, doctors prescribed testosterone injections at 200 mg every two weeks. However, many are moving towards more frequent dosing schedules, like 100 mg per week or even 50 mg twice per week, using insulin syringes. Sleep Apnea TRT and Sleep Quality Be cautious if you have central sleep apnea, as TRT can worsen this condition. However, weight loss achieved through TRT may improve obstructive sleep apnea over time. Erectile Function and Libido The Added Benefits and Limitations While TRT generally improves libido, the results regarding erectile function are mixed. Some men also use low-dose Cialis for additional cardiovascular benefits. Read more about the benefits of Cialis. Monitoring Your Blood Tests Taking Charge of Your Health One of the great advantages of modern technology is that you can monitor your own blood tests via DiscountedLabs.com, without needing a doctor's appointment. Telemedicine for TRT Access to Expertise For those living in areas without easy access to a TRT specialist, telemedicine is a viable option. Just note that most telemedicine doctors don't accept insurance. Prostate Cancer and Heart Attacks Debunking the Myths Contrary to common belief, TRT has not been proven to cause prostate cancer or heart attacks. Proper monitoring of hematocrit, HDL, and blood pressure is crucial, however. Community Support You're Not Alone Don't underestimate the value of community support. Platforms like Excel Male Forum offer a wealth of shared experiences and advice from men who have been on TRT for years. Important Blood Tests Beyond Total Testosterone Many doctors only measure total testosterone and often neglect other important markers like free testosterone, DHT, and thyroid function. Ensure these are part of your monitoring plan. Insurance Limitations Navigating the System Most insurance companies have limitations on which TRT products they cover. You can bypass insurance restrictions by going through a compounding pharmacy. Consult a Urologist The Go-To Experts on TRT Urologists are becoming increasingly knowledgeable about TRT, making them an excellent resource for anyone considering this treatment. Comorbidities Risks and Workarounds Some men might not see the benefits of TRT due to other health issues, such as metabolic disorders that can lead to water retention and high blood pressure. A full work-up with a cardiologist is advisable for these men. The Estradiol Obsession Re-Thinking Estradiol Management Many men obsess about their estradiol levels and are often prescribed high doses of aromatase inhibitors, which may not be necessary. Learn more about the role of estradiol in men here. In conclusion, TRT is a multifaceted treatment that requires proper understanding and management. Keep yourself informed and consider using DiscountedLabs.com for your testosterone level monitoring. Take control of your health today!

Table of Contents What are Estradiol and Aromatase? When aromatase is unbalanced, estradiol becomes an issue Low estrogen levels in men, not testosterone increases risk of heart disease Androgen deprivation therapy can cause cognitive decline Does estradiol restore cognitive function during ADT? Should high estradiol levels be treated? What are Estradiol and Aromatase? Estradiol is a form of the female hormone estrogen. Although estradiol production is typically considered a female concern, men also need to maintain healthy levels of this hormone for optimal health. Since men lack ovaries (where most estradiol is produced in women), estradiol in men is created by a process that uses an enzyme called aromatase (1) in testicles, liver and fat cells. Aromatase converts a very small portion of testosterone levels into estradiol, and health problems can arise when aromatase levels are too high or too low (1). When aromatase is unbalanced, estradiol becomes an issue As men age, they can experience excess aromatase activity, raising estradiol levels and reducing testosterone to unhealthy levels. Low T levels will adversely impact quality of life by reducing libido, ability to maintain an erection, mood, and muscle mass, among other health factors (2). However, when the body produces too little aromatase, men can experience other, potentially serious health problems. Men with diminished aromatase levels will have an estradiol deficit, which can create problems similar to low-T; diminished sex drive, loss of bone mass, and increased body fat (3). Men on testosterone replacement therapy (TRT) taking higher doses of aromatase inhibitors can also experience estradiol deficit. Let’s look at recent studies finding that low estradiol can play a critical role in increasing the risk of cognitive decline and increase the odds of experiencing cardiovascular disease. Low estrogen levels in men, not testosterone increases risk of heart disease A study led by Elaine Yu, MD, MSc, addresses the suspicion held by many medical professionals that testosterone can promote cardiovascular disease in men, and that estradiol provides protection against it (4). The researchers sought to determine whether it was estradiol or testosterone that regulated men’s cardiovascular risk factors by comparing two groups whose hormone levels were changed using a combination of medications (4). They looked at 400 healthy men, between the ages of 20 and 50. Study participants were weighed, had fasting blood tests for markers of heart disease and diabetes, and also had a thigh scan using quantitative computed tomography (CT scan) to measure muscle fat content before and after the study (4). Yu’s team found that while higher levels of testosterone reduced these men’s levels of healthy (HDL) cholesterol, changes in estradiol levels had no effect at all on HDL(4). However, they also discovered that low estradiol levels did increase the markers for diabetes, like increased insulin resistance, increased fat in the muscles, and higher fasting blood sugar levels(4). Diabetes is a major risk factor for heart disease (5). Additionally, the study found that neither estradiol nor testosterone affected the levels of LDL (unhealthy) cholesterol. According to Yu, these findings indicate that in men, it’s higher testosterone levels combined with lower estradiol levels that can worsen cardiovascular risk factors, somewhat explaining differences in the incidence of heart disease between men and women. Some studies have shown that it is the ratio of testosterone to estradiol that is important, not just the level of each of those hormones. As testosterone increases with TRT, so does estradiol to balance the effects of testosterone on lipids, mood and insulin action. Androgen deprivation therapy can cause cognitive decline Androgen deprivation therapy (ADT) is an often used method to slow the growth of prostate cancer. It’s also used for men transitioning to women (6, 7). ADT is typically prescribed on an open-ended (no fixed period) basis to help treat advanced prostate cancer. An estimated 44 percent of men with prostate cancer will undergo ADT at some point as part of a strategy to slow tumor growth (6). ADT therapy is used specifically to block the male hormones, particularly testosterone, from stimulating prostate cancer cell growth. Research has confirmed that ADT can cause significant cognitive decline in women with breast cancer (8), but few studies have investigated cognitive impairment following ADT for men being treated for prostate cancer. Using formal tests, scientists recently compared the cognitive ability of 58 prostate cancer patients receiving androgen deprivation therapy to 84 prostate cancer patients who did not receive ADT, and 88 cancer-free men (9). They found that those treated with ADT were 70 percent more likely to develop cognitive impairment after six months, and over twice as likely to have significant cognitive impairment after one year(9).   Does estradiol restore cognitive function during ADT? A 2018 study published in Current Neuropharmacology has examined whether estradiol supplementation is an effective way to prevent this side effect (9). Researchers performed a literature search using PubMed and Google Scholar to identify studies on this topic and discover any evidence that estradiol supplementation has a cognitive benefit for men on ADT. They examined studies involving the effects of estradiol treatment on cognitive function in three androgen-deprived male populations; prostate cancer patients, male-to-female transsexuals, and castrated male animals (9). A review of the literature found that while some studies show that estradiol supplementation resulted in cognitive improvement (especially in spatial ability), They couldn’t determine (9): Whether estradiol will improve cognition after long-term ADT How early or delayed estradiol treatment post-castration will affect cognition If estradiol affects memory retention They conclude that for androgen-deprived males, there is some evidence that estradiol supplementation may improve both verbal and visual memory (9). However the variability between the reviewed studies resulted in significant inconsistencies, making further study necessary to determine what estradiol treatment protocol can best maximize cognitive improvement for men using ADT (9). Should high estradiol levels be treated? Men on testosterone replacement therapy can experience an increase in estradiol that can sometimes reach clinically elevated levels (10). A study published in the Journal of Sexual Medicine (11) looks at the phenomenon of increased estradiol levels in men undergoing TRT to discover whether high estradiol levels in this population should be treated. Researchers comprehensively reviewed the published literature on the role of estradiols in male sexual function and testosterone deficiency to answer this question. The study findings reveal that (11): Although estradiol have been used at pharmacologic doses to suppress serum testosterone, there is no evidence that naturally occurring elevations of estradiol will cause a reduction in testosterone levels Absent testosterone deficiency, study findings suggest that elevated estradiol levels don’t seem to be harmful. Once again, monitoring and treating the ratio of testosterone to estradiol may be more important than either hormone alone. Estradiol could help maintain some sexual function in castrated men Given the evidence uncovered by this review study, researchers report that, although further research is needed, the existing evidence doesn’t support the treatment of elevated estradiol for men on testosterone therapy (11). WATCH LECTURE ABOUT ESTRADIOL IN MEN    BUY YOUR SENSITIVE ESTRADIOL TEST   References 1) Stocco, Carlos. “Tissue Physiology and Pathology of Aromatase.” Steroids 77.1-2 (2012): 27–35. PMC. Web. 11 June 2018. 2) Araujo, Andre B., and Gary A. Wittert. “Endocrinology of the Aging Male.” Best practice & research. Clinical endocrinology & metabolism 25.2 (2011): 303–319. PMC. Web. 11 June 2018. 3) Bulun, Serdar E. “AROMATASE DEFICIENCY.” Fertility and sterility 101.2 (2014): 323–329. PMC. Web. 11 June 2018. 4) Men's heart disease risk linked to high testosterone and low estrogen. The Endocrine Society. 5) Zhang PY. Cardiovascular disease in diabetes. Eur Rev Med Pharmacol Sci. 2014;18(15):2205-14. 6) Perlmutter, Mark A, and Herbert Lepor. “Androgen Deprivation Therapy in the Treatment of Advanced Prostate Cancer.” Reviews in Urology 9.Suppl 1 (2007): S3–S8. Print. 7) Unger, Cécile A. “Hormone Therapy for Transgender Patients.” Translational Andrology and Urology 5.6 (2016): 877–884. PMC. Web. 11 June 2018. 8) Wu, Lisa M., and Ali Amidi. “Cognitive Impairment Following Hormone Therapy: Current Opinion of Research in Breast and Prostate Cancer Patients.” Current opinion in supportive and palliative care 11.1 (2017): 38–45. PMC. Web. 11 June 2018. 9) Wibowo E. Cognitive Impacts of Estrogen Treatment in Androgen-Deprived Males: What Needs to be Resolved. Curr Neuropharmacol. 2017;15(7):1043-1055. 10) Tan RS, Cook KR, Reilly WG. High estrogen in men after injectable testosterone therapy: the low T experience. Am J Mens Health. 2015 May;9(3):229-34. doi: 10.1177/1557988314539000. Epub 2014 Jun 13. 11) Ravi Kacker, Abdulmaged M. Traish, Abraham Morgentaler. Estrogens in Men: Clinical Implications for Sexual Function and the Treatment of Testosterone Deficiency. The Journal of Sexual Medicine. (2012): Volume 9, Issue 6, Pages 1681–1696

Testosterone, a vital hormone predominantly found in males, plays a crucial role in various physiological processes such as sexual development, muscle growth, bone density, and overall well-being. Recent studies have raised concerns about a decline in serum testosterone levels among adolescents and young adult men in the United States. This article aims to explore the potential causes, implications, and scientific evidence surrounding this phenomenon. Factors Contributing to Declining Testosterone Levels in Young Men Lifestyle Changes Sedentary behavior, unhealthy dietary patterns, and an increase in screen time have been linked to lower testosterone levels. Lack of physical activity and poor nutrition can lead to weight gain, which is associated with reduced testosterone production [1]. Endocrine Disruptors Exposure to endocrine-disrupting chemicals (EDCs) such as phthalates, bisphenol A (BPA), and pesticides has been suggested as a potential contributor to declining testosterone levels. These chemicals, commonly found in plastics, personal care products, and certain foods, can interfere with hormonal balance and disrupt testosterone synthesis [2]. Stress and Mental Health Chronic stress and mental health disorders, including depression and anxiety, may negatively impact testosterone production. Elevated cortisol levels, often associated with stress, can suppress testosterone synthesis [3]. Obesity and Insulin Resistance The rising prevalence of obesity and insulin resistance among adolescents and young adults has been linked to lower testosterone levels. Excess body fat can promote the conversion of testosterone into estrogen, leading to hormonal imbalances [4]. Implications of Declining Testosterone Levels Sexual and Reproductive Health Testosterone is essential for normal sexual function, including libido, erectile function, and sperm production. Declining testosterone levels may contribute to sexual dysfunction and reduced fertility in affected individuals. Physical Health Testosterone plays a crucial role in maintaining muscle mass, bone density, and overall physical well-being. Decreased testosterone levels may lead to decreased muscle strength, increased risk of osteoporosis, and compromised overall health. Psychological Well-being Testosterone influences mood, cognition, and overall psychological well-being. Low testosterone levels have been associated with symptoms such as fatigue, depression, irritability, and reduced quality of life. Scientific Evidence and Studies A study published in the Journal of Clinical Endocrinology & Metabolism in 2006 analyzed data from the National Health and Nutrition Examination Survey (NHANES) and found a significant decline in testosterone levels among men aged 20-74 years between 1988 and 2004 [5]. Another study published in JAMA Internal Medicine in 2020 examined testosterone levels in over 4,000 young men aged 15-39 years from 2009 to 2016. The findings indicated a substantial decline in testosterone levels during this period [6]. Research published in the journal Environmental International in 2020 explored the association between phthalate exposure and testosterone levels in young men. The study suggested that higher urinary phthalate metabolite concentrations were associated with lower testosterone levels [7]. Conclusion The decline in serum testosterone levels among adolescents and young adult men in the USA is a concerning trend with potential implications for sexual and reproductive health, physical well-being, and psychological functioning. Lifestyle factors, endocrine disruptors, stress, obesity, and insulin resistance are among the factors contributing to this decline. Further research is needed to understand the extent of the issue and develop strategies to address and mitigate the potential consequences. Buy the most affordable testosterone test in the country on DiscountedLabs.com References: Araujo AB, Dixon JM, Suarez EA, et al. Clinical review: Endogenous testosterone and mortality in men: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2011;96(10):3007-3019. Haider A, Yassin A, Doros G, Saad F. Effects of long-term testosterone therapy on patients with "diabesity": results of observational studies of pooled analyses in obese hypogonadal men with type 2 diabetes. Int J Endocrinol. 2014;2014:683515. Morales A, Bebb RA, Manjoo P, et al. Diagnosis and management of testosterone deficiency syndrome in men: clinical practice guideline. CMAJ. 2015;187(18):1369-1377. Almeida OP, Hankey GJ, Yeap BB, et al. Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men. Arch Gen Psychiatry. 2008;65(3):283-289. Travison TG, Araujo AB, O'Donnell AB, et al. A population-level decline in serum testosterone levels in American men. J Clin Endocrinol Metab. 2007;92(1):196-202. O'Connor DB, Archer J, Wu FC. Effects of testosterone on mood, aggression, and sexual behavior in young men: a double-blind, placebo-controlled, cross-over study. J Clin Endocrinol Metab. 2004;89(6):2837-2845. Hammoud A, Gibson M, Peterson CM, et al. Impact of male obesity on infertility: a critical review of the current literature. Fertil Steril. 2008;90(4):897-904.

Table of Contents SHBG and the Free Testosterone Relationship What Causes High SHBG? Other factors that can contribute to high SHBG include:   Get Your Levels Checked: SHBG Test, Free & Total Testosterone Test How to Lower SHBG Levels: Very Low SHBG : Low SHBG has also been associated with: Is SHBG an Enemy of Hormone? - Emerging Studies References: Testosterone is the primary and dominant male hormone. It is responsible for numerous functions within the human body in men and women, and when levels are too low, it can lead to multiple health issues. Unfortunately, as many know, testosterone levels naturally decline as we age. Numerous external factors can contribute to lower levels of testosterone. In either case, age or external, symptoms occur, problems arise, and solutions are needed to stop the decline. For many men, testosterone replacement therapy (TRT) is the answer to this problem.  Men should ensure that their testosterone free and total, estradiol and other hormone factors are within normal levels. One of those hormone tests to monitor is the Sex Hormone Binding Globulin (SHBG) test.   SHBG and the Free Testosterone Relationship   When our body produces testosterone or provides it exogenously, a set level of testosterone flows through the body. This testosterone blood level can be measured precisely through a simple blood test aptly referred to as the Total Testosterone blood test. For most adult men, when testing their total testosterone, if it falls in the 350 ng/dl to 1100 ng/dl range, this will be considered medically optimal. Such individuals, even exhibiting low testosterone symptoms, will often not be prescribed TRT. In some cases, this may be a correct diagnosis; in other cases, symptoms exist for different reasons, but in most cases, something else is at play, which makes SHBG important.   While useful, measuring total testosterone is only useful with also measuring Free Testosterone. Free testosterone is a small fraction of your total testosterone. It is often referred to as "unbound," meaning the testosterone your body will use for its intended androgenic function. Free testosterone is so important that if your total testosterone levels are within range, if free testosterone levels are low, in most cases, the man will be symptomatic of low testosterone. This issue is often due to high levels of SHBG in the body.   For this reason, many men will attempt to lower their SHBG or even fret over it. However, SHBG serves an essential purpose. As is with estrogen, too much can be problematic, but so can too little. SHBG is no different.   Of all the testosterone flowing through your body, only 2% is what we can refer to as unbound or free testosterone. From a layman's perspective, to increase free and unbound testosterone, they'd need to increase their total testosterone. Unfortunately, it doesn't always work that way – it often helps and often fixes the issue, but not always – and here's why: our testosterone is bound to albumin and sex hormone-binding globulin (SHBG). Approximately one-third of total testosterone binds to albumin, and the rest to SHBG.   Albumin is a protein that binds testosterone, and we can say it does so loosely. This protein carries testosterone through the bloodstream and releases it as needed. The testosterone detaches and becomes what's often referred to as bioavailable or free testosterone. The testosterone that separates from albumin becomes the testosterone that influences your body's functions from sex organs, muscle tissue, brain function, and a host of other areas of bodily function. Testosterone attached to SHBG cannot do this; it is attached and does not detach.   What Causes High SHBG?   As testosterone attached to SHBG is relatively useless, if SHBG levels increase within the body, there will be more attaches and less free testosterone to circulate. Conversely, lower levels of SHBG are associated with higher levels of free testosterone, which is often associated with positive influences on bodily functions, such as libido, mood, muscle mass, etc.   Numerous factors influence how much sex hormone-binding globulin we have in our bodies. Age is one of the primary factors that affect SHBG. Often as we age, SHBG levels increase, and as a result, free testosterone levels go down. Even if our total testosterone levels remain high or optimal, our bioavailable testosterone decreases if SHBG levels increase.   Other factors that can contribute to high SHBG include: Fatty Liver Excessive or what we might call chronic alcohol consumption can lead to a fatty liver and impending higher levels of SHBG and corresponding lower levels of free testosterone. The disease can also be a factor, such as cirrhosis or cancer. Thyroid issues An underactive and overactive thyroid can lead to elevated SHBG, not to mention issues associated with the thyroid. Overactive thyroid or hyperthyroidism is often associated with graves' disease, thyroid nodules, or thyroiditis. It can also exist due to abuse of thyroid medications, such as Cytomel (T3). Underactive thyroid or hypothyroidism may be caused by inflammation of the thyroid gland, pituitary damage, too little iodine in the diet, or genetic factors, along with other possible reasons. Elevated estradiol High levels of estradiol can occur for numerous reasons, which are not limited to using certain antibiotics, some mental health medications, obesity, and abuse of exogenous testosterone. Obesity & High triglycerides While not as expected of a factor for increasing SHBG, being overweight with a low lipid profile can negatively impact. Inflammation While some level of inflammation is necessary for general health in the fight against disease or injury, what we might call chronic inflammation can lead to increases in SHBG and corresponding lower levels of free testosterone   Get Your Levels Checked: SHBG Test, Free & Total Testosterone Test   Testing your SHBG levels along with both total and free testosterone is particularly important if one wants to get to the bottom of hypogonadism (low testosterone) symptoms they may be experiencing. Remember, a total testosterone test alone, which some physicians will run, is not enough. For most adult men, SHBG levels will run between 10 nmol/L and 60 nmol/L if in the optimal range. If SHBG levels are greater than 60 nmol/L and your free testosterone is less than 2% of your total testosterone, there is a good chance your SHBG levels are too high.   Discounted Labs sells several lab test panels that measure SHBG levels that you can buy without a doctor's visit:   Testosterone (Total and Free), SHBG, CBC - Hematocrit, Ultrasensitive Estradiol and PSA   Testosterone, Free, Bioavailable and Total (Upper Limit T 1,500 ng/dL) plus SHBG   CBC, CMP, TT, FT, Lipids, Prolactin, Ultra-Sensitive Estradiol, and SHBG   Testosterone, Free, Bioavailable, and Total, LC/MS (No Upper Limit) plus SHBG   As we now understand SHBG, our next question is what can be done to lower it, increasing free testosterone in the body? There is nothing we can do about aging. As each day passes, we grow older, but there are still things we can do that will improve this factor.   How to Lower SHBG Levels:   The most obvious answer to the problem of low free testosterone and high levels of SHBG is to increase testosterone. Exercise more, consume a cleaner diet, and lose weight; all of these things will increase your testosterone levels. Your levels may not increase massively, but some increase means a higher total to pull from and a greater amount of free testosterone based on the 2% fraction. If this isn't enough - perhaps you're not reaching a 2% fraction due to elevated SHBG – one may need to consider talking to their doctor about testosterone supplementation. However, even if supplementing with exogenous testosterone, the habits mentioned are good for overall health and can only have a positive impact.   Another possible solution, and one of the more commonly needed, is lowering estradiol levels in the body. We tend to think estrogen hormones are needed for females only, but they are also crucial for men, granted in smaller amounts. As it pertains to estrogen, too much estradiol can lead to elevated levels of SHBG. If testosterone levels are also low, this can lead to even more negative factors. But it's important not to get carried away as estradiol that's too low will bring with it numerous symptoms; in fact, your life could be miserable in that regard.   Many men who are at least somewhat familiar with testosterone have been wrongly been told that too much testosterone can lead to gynecomastia due to elevated levels of estrogen in the body due to the aromatization of testosterone to estrogen. But low levels of testosterone in the body with present high levels of SHBG and estradiol can have the effect of causing gynecomastia. In order to combat high levels of estradiol, avoiding certain foods, especially those that are soy-based, will be important. Equally important is living a healthy lifestyle and incorporating what was mentioned above: adequate exercise, a healthy diet, and getting enough sleep. These things will help lower estradiol. Some men will also need medical help through medications known as aromatase inhibitors if they have gynecomastia, although most men on TRT do not need an AI. Too many men have relied on aromatase inhibitors out of fear for too many years. In reality, most men who supplement with exogenous testosterone can, in fact, control estrogen via non-medicated factors.   Some studies have shown that supplementation with DHEA (Dehydroepiandrosterone) may also lower SHBG. However, more study is needed to understand this properly, as too much DHEA can prove problematic. High doses of DHEA supplements have been associated with increased estradiol, so you must speak to your doctor first before beginning such a supplementation regimen.   Very Low SHBG :   We are then left with one factor we've yet to discuss much because it isn't all that common: low SHBG, or rather, levels of SHBG that are too low. Levels of SHBG that are too low may be an indicator of other underlying health issues. This may be an indicator of a metabolic problem. Low levels of SHBG are a standard indicator of those with diabetes. It doesn't appear, as data suggests, that insulin resistance is caused by low SHBG, but it may be a useful marker. More data is currently needed on this topic.   An A1c test will be needed to know with certainty in terms of your diabetic health.   While low SHBG is not a common concern for most men, new data has produced interesting results and information. A recent study published in the Journal of Clinical Endocrinology and Metabolism provides such information.   The process showed a man with undetectable levels of SHBG and low levels of testosterone accompanied by nearly a decade of hypogonadism symptoms. They discovered a family with a missense mutation in the SHBG gene from studying this individual. Interestingly enough, they found this issue did not interfere with the individual's spermatogenesis or general gonadal development. This leads the study to conclude SHBG may not play a significant role in the maturation of the male species physiologically or sexually.   More interesting than the JCEM study is things that new data suggest may negatively impact all men. Low levels of SHBG have recently been associated with three medical conditions that are known to be the silent killers of many men: heart disease, metabolic syndrome, and diabetes. Again, currently, it is being viewed as a marker and not as direct causation, but this new information is important as it acknowledges that more studies must be done.   Low SHBG has also been associated with:   Obesity Obesity is a factor we all well understand and is an issue that leads to problems in many health areas, and often in numerous possible directions. Cushing Disease It is associated with extended exposure to high levels of cortisol. Hypothyroidism It is associated with an under-active thyroid. Excessive levels of growth hormone Exceedingly rare for most, although possible via genetic factors or abuse of exogenous forms. Abuse through anabolic steroids     Is SHBG an Enemy of Hormone? - Emerging Studies   As we mentioned, androgens like testosterone and DHEA and estrogens are transported to the sex hormone binding globulin (SHBG). SHBG is believed to keep sex hormones inactive and to control the amount of free hormones that enter cells by passive diffusion. Contrary to the free hormone hypothesis, some researchers have demonstrated that megalin, a receptor in ovaries and testicles, acts as a pathway for cellular uptake of biologically active androgens and estrogens bound to SHBG. We will see more data on this newly found receptor that actually enables the body to use hormones bound to SHBG in the near future.   In endocrinology, the body has no “harmful” or “good” hormone. Their balance and harmony with each other matters for the best health.     References:   Ding et al. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. The New England Journal of Medicine. Aug 2009. Vos et al. Sex Hormone Binding Globulin Deficiency Due to a Homozygous Missense Mutation. Journal of Clinical Endocrinology and Metabolism. Sept 2014 SHBG and Free Testosterone - Everything You Need to Know Hammes et al. Role of Endocytosis in Cellular Uptake of Sex Steroids. Cell. Sept 2005  

  Pondering about the perfect Father's Day gift? Are you contemplating a case of his favorite craft beer, premium Omaha steaks, or maybe a surprise getaway to his favorite city? All these are excellent choices to show appreciation to your father on this special day. But what if there's a more impactful gift - the gift of health? As men age, their health often becomes a challenge. Conditions ranging from fatigue, muscle loss, joint pains to reduced flexibility are commonplace. Some issues, like unexplained tiredness, low mood, frequent illnesses, and doctor visits, might be less conspicuous yet more concerning. Does this ring a bell? Father's Day Lab Test Sale Fret not! Here's an innovative solution. This Father's Day, consider gifting your father a lab test from DiscountedLabs.com. It's a proactive step towards ensuring his optimum health, with no doctor's visit required! Use this discount code FATHERSDAY20 to save 20% on your lab test order, valid until June 30, 2023. Beneficial Lab Tests for Older Men: Consider these potentially life-enhancing tests for your dad: Annual Physical Panel - A comprehensive health check including CBC, CMP panels, A1C, TSH (thyroid function), urinalysis, and lipid profile. Total and Free Testosterone Test - A measure of your father's testosterone levels to ensure he maintains a healthy hormonal balance for his age. Thyroid Panel - A comprehensive assessment of his free T3 and free T4 thyroid hormones, providing insights into potential thyroid-related health issues. A medical checkup as a gift may sound unconventional, right? Yet, once you peruse these studies, you'll understand why such tests are invaluable for your father's health and well-being. The Power of Testosterone in Older Men: Recent studies underscore the immense benefits of healthy testosterone levels in men, even beyond their prime years. Three independent studies discovered that men with optimal testosterone levels enjoyed better health. For men over 65, testosterone treatment helped achieve hormone levels typical for a 19- to 40-year-old, yielding noticeable improvements: 8% enhanced performance in a 6-minute walking test. Reported better moods and significantly lower rates of depression. Improved mood and increased energy production, although no reduction in the risk of cardiac events and prostate conditions was noted. Reduced Hospitalization Rates with Testosterone: A May 2016 Mayo Clinic study discovered that men undergoing testosterone therapy were less likely to be rehospitalized within 30 days of hospital discharge. The therapy especially benefited men with low testosterone levels, reducing their chances of readmission due to testosterone deficiency-related health issues. Combatting Depression with Testosterone: Research indicates a correlation between lower levels of circulating testosterone and depression in men. A study following over 3,100 older men for a decade found that those who developed depression had significantly lower total testosterone levels. This revelation implies that checking and adjusting testosterone levels can help manage depression commonly found in older men. Give the Gift of Health: This Father's Day, empower your father with the gift of knowledge about his health. Through these tests, he'll gain insights into his body's inner workings. He'll learn about his thyroid and testosterone levels and their potential impact on his well-being. Perhaps, testosterone therapy could be his key to a happier, healthier life. This Father's Day, give your father a gift that will keep giving for years to come. Take a proactive step towards his health today, contributing to a longer, healthier life. Remember to use the DiscountedLabs.com coupon code: FATHERSDAY20 and give your father the gift of a healthier tomorrow! Where Does Discounted Labs Operate?  If you live in one of the following states, you can take advantage of our discounted blood work: Alabama, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana, Nebraska, Nevada, North Carolina, New Mexico, Ohio, Oklahoma, Oregon, Pennsylvania, South Carolina, Tennessee, Texas, Utah, Virginia, Washington, and West Virginia. We do not serve NY, NJ, RI, and AZ. How Does Discounted Labs Work? 1-     Click on the Lab Near You page to ensure we serve your state and that a location is near you.  2-     If a location is near you, go to "Choose a Test" and add your selection (s) to the shopping cart. You can also save money by buying bundled lab test panels. 3-     If you have a discount coupon code, add it to your cart. 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You will receive them by email as soon as they come in. Please contact us if you have any questions. We also have answered a lot of questions in our Frequently Asked Questions page IF YOU WOULD RATHER WATCH A VIDEO DESCRIBING HOW WE WORK: HOW TO ORDER DISCOUNTED LABS ONLINE Why DiscountedLabs.com? We Have the Most Affordable Lab Tests Available in the U.S. No Doctor Visit is Required. Our In-House Doctor Provides a Prescription at No Extra Cost to You. Private and Confidential Lab Test Results. We Serve Most U.S. States. In Operation for Over 8 Years. Orders are Valid for 6 Months. Simple Menu and Process.  Order 24/7 You Get a Lab Requisition Form A Few Minutes After Your Order. No, Wait. No Hidden Costs. An $8 Lab Draw Fee is Added to Your Order. Our Blood Tests are FDA Approved. We are HIPAA Compliant. We Protect Your Privacy. Your Order is Good for 180 Days. You Do Not Have to Rush to the Lab. Over 1,900 Lab Locations Around the United States. No Appointment is Needed. 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  Discovering natural testosterone boost methods can significantly impact your overall health and wellness. Testosterone is a key hormone that helps to regulate sexual functioning, hair development, and sustaining muscle mass. As we get older, our testosterone levels drop, so it's important to find ways to raise and maintain healthy levels. To maximize your testosterone levels, we will look into the benefits of exercise regimens such as weightlifting and HIIT, dietary strategies with zinc, vitamin D and magnesium-rich foods, sleep quality for hormonal regulation, and stress management techniques like meditation and yoga. We'll talk about nutrition tips by looking at foods high in zinc, vitamin D, and magnesium, which help the body make the most testosterone. Furthermore, we'll discuss the significance of sleep quality for hormonal regulation while providing practical stress management techniques such as meditation and yoga. Last, we'll look at how a healthy body weight helps keep testosterone levels at the right level. Embark on this journey towards better health by incorporating these evidence-based approaches into your daily routine. Table of Contents: Exercise to Boost Testosterone Weightlifting and Resistance Training High-Intensity Interval Training (HIIT) Nutrition for Testosterone Support Foods High in Zinc Vitamin D-Rich Sources Importance of Sleep Quality Targeting 7-9 Hours Per Night Establishing a Consistent Sleep Schedule Stress Management Techniques Meditation Practices Yoga as Stress Relief Maintaining Healthy Body Weight Losing Excess Fat Through Diet and Exercise Frequently Asked Questions Natural Testosterone Boost What increases testosterone the most naturally? Does anything naturally increase testosterone? What is the fastest way to increase testosterone naturally? Conclusion Exercise to Boost Testosterone Regular exercise, particularly weightlifting and resistance training, can significantly increase testosterone levels. HIIT is another approach that can be utilized to enhance hormone production. Boosting your natural testosterone levels will work best if you do a mix of these exercises as part of your routine. Weightlifting and Resistance Training Studies have shown that engaging in regular weightlifting and resistance training stimulates the release of anabolic hormones like testosterone. These types of workouts help build muscle mass, which contributes to higher overall hormone production. Focus on exercises like squats, deadlifts, bench presses, rows, and pull-ups that work multiple muscle groups at once to get the most out of weightlifting and resistance training. Squats Deadlifts Bench Presses Rows Pull-ups High-Intensity Interval Training (HIIT) In addition to traditional strength-training exercises like weightlifting or resistance-based workouts, HIIT has been found to be effective at increasing testosterone levels naturally. HIIT is made up of short, intense bursts of activity with short breaks in between for rest or low-intensity movement. The intensity level during these intervals should be high enough that you're unable to maintain it for more than about a minute before needing recovery time. An example HIIT workout could include the following: Warm-up for 5 minutes with light jogging or jumping jacks Sprint at maximum effort for 30 seconds Rest or walk for one minute to recover Repeat steps two and three for a total of six rounds (or more, depending on your fitness level) Cool down with stretching exercises and deep breathing techniques. By doing both weightlifting and HIIT workouts as part of your exercise routine, you can naturally boost your testosterone levels and get in better shape overall. Before starting a new exercise program, you should always talk to a doctor or nurse, especially if you already have health problems or concerns. Physical activity is an important part of staying healthy, and it can also help boost testosterone production. Nutrition also plays a role in supporting optimal hormone balance, so let's take a look at some foods that may be beneficial for boosting testosterone.   Key Takeaway: This article outlines how weightlifting and resistance training, as well as HIIT workouts, can help boost testosterone levels naturally. Regular exercise focusing on compound movements such as squats and deadlifts, plus periods of high-intensity activity followed by rest, can give your hormones a much needed boost. Nutrition for Testosterone Support For healthy hormone levels, you need a diet that is well-balanced and full of vitamins and minerals that help make testosterone. Focusing on eating foods with a lot of zinc, vitamin D, and magnesium can help naturally boost testosterone levels and improve health in general. Foods High in Zinc Zinc plays a crucial role in the production of testosterone. A deficiency in this mineral can lead to reduced hormone levels. Some excellent sources of zinc include: Oysters Red meat (beef, lamb) Poultry (chicken, turkey) Legumes (beans, lentils) Nuts and seeds (almonds, pumpkin seeds). Vitamin D-Rich Sources Consuming foods high in vitamin D, such as nuts and seeds (almonds, pumpkin seeds), fatty fish (salmon, mackerel), egg yolks, cheese, and mushrooms exposed to UV light, has been linked to increased testosterone levels. Exposure to sunlight is one way to increase your body's natural production of vitamin D; however, it's also important to consume foods rich in this nutrient: Fatty fish (salmon, mackerel) Egg yolks Cheese Mushrooms exposed to UV light l0 > Fortified dairy products Milk Orange juice Magnesium - Rich Foods Magnesium is another essential mineral that supports testosterone production . By incorporating magnesium - rich foods into your diet , you can help maintain optimal hormone levels . Some excellent sources of magnesium include : Leafy greens (spinach, kale) Whole grains (brown rice, quinoa) Nuts and seeds (almonds, sunflower seeds) Legumes ( black beans , chickpeas ) li > Dark chocolate Avocado By focusing on a balanced diet rich in these key nutrients , you can support healthy testosterone production and improve overall well-being. A dietary regimen full of zinc, vitamin D and magnesium is key to sustaining healthy testosterone levels. Getting enough shut-eye on a regular basis can help keep testosterone levels at their best. "Boost testosterone naturally with foods high in zinc, vitamin D and magnesium. Make sure to include oysters, red meat, poultry, legumes & nutsseeds for optimal health. #TestosteroneSupport #NutritionTipsClick to Tweet Importance of Sleep Quality Adequate sleep plays a critical role in boosting testosterone levels since most of the hormone gets produced during deep sleep stages. To get the most health benefits from your hormones, you need to pay attention to both how much and how well you sleep. Aim to get 7-9 hours of sleep each night and establish a consistent sleeping pattern for optimal hormonal health benefits. Targeting 7-9 Hours Per Night Getting enough restorative sleep each night is crucial for maintaining healthy testosterone levels. Aim for 7-9 hours of uninterrupted sleep to ensure your body has enough time to produce hormones like testosterone. If you have trouble getting enough sleep, try doing some relaxation exercises before bed or changing your sleeping environment to make it less noisy and bright. Engage in calming activities such as reading or taking a warm bath prior to bedtime to help create a relaxing routine. Limited screen time: Avoid using electronic devices close to bedtime as they emit blue light that can interfere with melatonin production - the hormone responsible for regulating our sleep-wake cycle. Maintain an ideal room temperature: A cooler bedroom (around 60-67°F) promotes better-quality slumber compared to warmer temperatures. Establishing a Consistent Sleep Schedule In addition to ensuring you get enough hours of shut-eye each night, it's equally important that you maintain regularity in your sleeping patterns. Going to bed and waking up at roughly the same times daily helps regulate your body's internal clock, leading to improved sleep quality and, ultimately, higher testosterone levels. To establish a consistent sleep schedule: Set a fixed bedtime and wake-up time that allows for 7-9 hours of rest. Avoid napping during the day as it can disrupt your nighttime sleep pattern. Limit caffeine intake in the afternoon and evening since it may interfere with falling asleep at night. By paying attention to both how much and how well you sleep, you'll take an important step toward increasing your testosterone levels in a natural way. Remember that creating healthy habits takes time; therefore, be patient with yourself as you work towards improving your overall hormonal health through better sleeping practices. Aim to get 7-9 hours of restful sleep each night and set a regular bedtime for the best testosterone production. To further improve your natural testosterone levels, consider implementing stress management techniques such as meditation practices or yoga into your daily routine.   Key Takeaway: Achieving a sound night's sleep is essential for elevating testosterone levels, so aim to get 7-9 hours of restful slumber daily and stick to consistent sleeping patterns. Establishing healthy habits like creating a relaxing bedtime routine, limiting screen time, and keeping the room temperature cool will all help you achieve this goal. Stress Management Techniques High cortisol levels can hurt hormone production, so managing stress is important for keeping testosterone levels at their best. By incorporating various stress-relief practices into your daily routine, you can effectively enhance your hormonal health without relying solely on medical interventions or supplements alone. In this section, we will discuss two popular techniques that help reduce stress and promote overall well-being: meditation and yoga. Meditation Practices Meditation has been proven to be an effective method of reducing stress and promoting relaxation. By engaging in regular practice, one can become more conscious of oneself and cultivate greater concentration, as well as a feeling of inner serenity - all leading to decreased cortisol levels. There are various forms of meditation available to suit individual preferences such as mindfulness meditation, loving-kindness meditation (metta), transcendental meditation (TM), or guided visualization techniques. Mindfulness Meditation: This technique involves focusing on the present moment while acknowledging thoughts and emotions without judgment. Loving-Kindness Meditation (Metta): Metta encourages practitioners to develop feelings of compassion towards themselves and others by silently repeating positive phrases like "May I be happy." Transcendental Meditation (TM): TM requires sitting comfortably with eyes closed for about 20 minutes twice a day while silently repeating a specific mantra given by an instructor. Guided Visualization:This form uses mental imagery to create relaxing scenarios in one's mind; it often includes soothing background music or nature sounds. Yoga as Stress Relief Yoga is another effective stress management technique that combines physical postures, breathing exercises, and meditation to promote relaxation and overall well-being. Regular practice of yoga has been shown to reduce cortisol levels while improving mood, flexibility, strength, and balance. There are various styles of yoga available for different preferences, such as Hatha Yoga (gentle), Vinyasa Flow (dynamic), Yin Yoga (restorative), or Ashtanga Yoga (rigorous). Hatha Yoga: This gentle style focuses on slow movements with deep breathing techniques; it's ideal for beginners or those seeking a relaxing experience. Vinyasa Flow: A dynamic form of yoga that synchronizes breath with movement in a continuous flow; suitable for individuals who prefer an energetic workout. Yin Yoga: Restorative poses held for longer periods help release tension from the body's connective tissues; perfect for promoting relaxation and flexibility. Ashtanga Yoga:A rigorous practice involving six series of specific postures performed in sequence; best suited for experienced practitioners looking to challenge themselves physically and mentally. Incorporating these stress management techniques into your daily routine can significantly improve hormonal health by reducing cortisol levels, which negatively impact testosterone production. By committing to regular meditation or yoga sessions under professional guidance if needed - men can effectively enhance their natural testosterone levels without relying solely on medical interventions or supplements alone.   The main idea of this article is that meditation and yoga are good ways to deal with stress and can help lower cortisol levels and increase natural testosterone production. To achieve optimal hormonal health, men should incorporate these practices into their daily routines, with professional guidance if needed. Maintaining Healthy Body Weight One of the most effective ways to boost your natural testosterone levels is by maintaining a healthy body weight. Excess fat, particularly in the abdominal area, can lead to lower testosterone levels, negatively impacting various aspects of men's health such as sexual function and energy levels. But it's important not to cut calories too much or work out too much, which can hurt hormone balance instead of helping it. Losing Excess Fat Through Diet and Exercise To shed excess body fat while preserving muscle mass, focus on incorporating both cardiovascular exercises and resistance training into your fitness routine. Cardiovascular activities like running, swimming, or cycling help burn calories effectively, while resistance training promotes lean muscle growth, which in turn boosts metabolism and supports hormonal health. Cardiovascular exercises: Running, swimming, cycling Resistance training: Weightlifting, bodyweight exercises (e.g., push-ups) A balanced diet is just as important as regular exercise when it comes to maintaining a healthy body weight. Emphasize consuming nutrient-dense foods rich in protein for muscle repair and growth, along with plenty of fruits and vegetables for vitamin and mineral support. Dietary Tips for Losing Excess Fat: Eat lean sources of protein: chicken breast, turkey breast, fatty fish (salmon), legumes Increase fiber intake through whole grains: brown rice, li>quinoa Avoiding Extreme Calorie Restriction. While cutting down on calorie intake is necessary for weight loss, it's crucial not to take this approach too far. Extreme calorie reduction can result in a decrease in muscle mass and testosterone, which goes against the goal of enhancing hormonal balance. Instead, focus on making a moderate calorie deficit by eating foods that are high in nutrients, make you feel full, and fuel your workouts well. Seeking Professional Guidance If you're unsure about the best approach for achieving healthy body weight or need personalized advice tailored to your specific needs, consider consulting with healthcare experts such as dietitians or personal trainers who can provide valuable guidance based on their expertise. By following professional recommendations and making sustainable lifestyle changes, you'll be well-equipped to maintain healthy testosterone levels while enjoying overall improved wellbeing.   Key Takeaway: This article explains the significance of maintaining a proper body weight to increase natural testosterone, as well as offering advice on how to do so through food and physical activity. It emphasizes avoiding extreme calorie restriction or excessive exercising, as well as seeking professional guidance if needed - all key components in achieving optimal hormonal health. Frequently Asked Questions Natural Testosterone Boost What increases testosterone the most naturally? Getting regular exercise, especially weightlifting and high-intensity interval training (HIIT), and eating a well-balanced diet with lots of zinc, vitamin D, and magnesium can raise testosterone levels by a lot. Getting enough sleep and dealing with stress through things like meditation or yoga also help keep testosterone levels at a healthy level. Does anything naturally increase testosterone? Yes, several factors can help boost natural testosterone production. These include engaging in resistance training exercises, consuming foods high in zinc such as oysters and red meat, getting adequate sunlight exposure for vitamin D synthesis, or eating vitamin D-rich foods like fatty fish and eggs. Managing stress effectively also supports healthy hormone balance. What is the fastest way to increase testosterone naturally? The fastest way to raise natural testosterone levels is to take a comprehensive approach that includes consistent weightlifting or resistance training sessions along with high-intensity interval training (HIIT) workouts, eating a nutrient-dense diet high in zinc, magnesium, and vitamin D, getting a good night's sleep, and practicing stress management techniques like yoga or meditation. Conclusion In conclusion, a natural testosterone boost is achievable through a combination of lifestyle changes. Exercise and a nutritious diet are necessary for maintaining proper testosterone levels in the body. Getting adequate sleep can help regulate hormones, while stress management techniques such as yoga or meditation can reduce cortisol levels that may be impacting your hormone balance. Lastly, keeping a healthy weight will be good for your overall health and wellness, including making your body make more natural testosterone. 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