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  Bodybuilding is a tough sport and requires a lot of work and dedication, especially when it comes to maximizing benefits and minimizing side effects of testosterone and anabolic androgenic steroids (AAS). With the right training and nutrition, you can gain muscle, lose fat and get stronger. But you have to keep an eye on your health through chosen lab tests and panels, especially when there are obstacles to care brought by stigma and medical professionals’ judgment. Proper nutrition, supplementation, and adequate rest are crucial for effective muscle recovery and overall training success. Insufficient recovery can lead to issues like overtraining and decreased performance. In this article we will talk about harm reduction and list 14 lab tests and panels for bodybuilders to stay healthy while improving body composition and strength. Bodybuilders who use testosterone and anabolic androgenic steroids (AAS) need to be smart about maximizing benefits and minimizing short-term and long-term side effects while exercising and eating well for muscle gain, fat loss, and quality of life. Anabolic hormones like growth hormone, testosterone, and insulin are key to muscle growth and strength training. This way they can get the most out of their testosterone and AAS use. Reduced harm is important, especially when there are obstacles to care like stigma and criticism from medical professionals. Understanding Blood Tests for Bodybuilders Blood tests are a crucial tool for bodybuilders to monitor their health, track their progress, and optimize their training and nutrition strategies. By understanding the importance of blood tests, bodybuilders can make informed decisions about their training and nutrition, and avoid potential health risks. Importance of Blood Tests Blood tests provide valuable insights into a bodybuilder’s overall health and fitness level. They can help identify potential issues with hormone balance, overtraining, and nutrition, and provide a baseline for tracking progress over time. Regular blood tests can also help bodybuilders detect any underlying health disorders that could affect their performance. For instance, a comprehensive metabolic panel can reveal imbalances in glucose levels, kidney function, and liver enzymes, which are critical for maintaining optimal health during intense training. By regularly monitoring these markers, bodybuilders can adjust their training and nutrition strategies to ensure they are supporting their muscle growth and overall health. Bodybuilder Tests: Here are 14 lab tests and panels to keep you healthy while improving body composition and strength: Take blood sample after waking and before intense physical activity for accurate testing of specific health markers for male bodybuilders and weightlifters. Complete blood count (CBC) Here are the components of your blood that are measured by a complete blood count (CBC) test panel: red blood cells which carries oxygen; white blood cells which fights infection; hemoglobin which is the protein in red blood cells that carries oxygen; hematocrit which is the ratio of red blood cells to the fluid component in your blood (which correlates with blood thickness); and platelets which aids in blood clotting. All androgens including testosterone and anabolic androgenic steroids (AAS) can increase red blood cells and its proportion in the blood (hematocrit) thus increasing blood thickness (polycythemia). High hematocrit is associated with cardiovascular disease, high blood pressure and headaches. This panel is important because it will tell you if you have reached 53 hematocrit which means you need to donate blood or undergo therapeutic phlebotomy. Given the physical demands of intense training it’s important to monitor health markers like kidney and liver function through regular blood tests to prevent overstraining the body. Tests included in the CBC panel: White blood cell count (WBC or leukocyte count) WBC differential count Red blood cell count (RBC or erythrocyte count) Hematocrit (Hct) Hemoglobin (Hgb) Mean corpuscular volume (MCV) Mean corpuscular hemoglobin (MCH) Mean corpuscular hemoglobin concentration (MCHC) Red cell distribution width (RDW) Platelet count Mean Platelet Volume (MPV) Complete Metabolic Profile (CMP) The complete metabolic profile, also known as CMP panel, is a medical screening test that consists of 14 blood tests and is used to assess overall health. CMP blood test panel checks fluid and electrolyte balance, glucose level, kidney and liver function and electrolyte levels. FASTING IS REQUIRED. Tests: Glucose Sodium Potassium Chloride Carbon Dioxide Calcium Protein Albumin Alanine transaminase (ALT) Aspartate transaminase (AST) Bilirubin Alkaline phosphatase (ALP) Blood urea nitrogen (BUN) Creatinine eGFR Lipid Profile This panel includes LDL which is known as “bad cholesterol”, HDL which is known as “good cholesterol” and triglycerides (fatty acids in the blood). Higher dose of T or AAS may increase LDL cholesterol and decrease HDL cholesterol and triglycerides. Significant drop in HDL may lead to cardiovascular problems in the long run. FASTING IS NEEDED. Cystatin C and EGFR Kidney Tests Cystatin C is a more accurate way of measuring kidney function in individuals with higher muscle mass. This is because factors like increased muscle mass, protein intake and creatine supplementation can affect the use of creatinine as the primary variable. Cystatin C is more reliable. Estimated glomerular filtration rate is another parameter used to assess kidney function (eGFR). The rate at which fluid is filtered through the kidney is called glomerular filtration rate. Creatinine clearance rate, also known as CCRCr or CrCl, is a good estimate of glomerular filtration rate (GFR). It is the volume of blood plasma cleared of creatinine per unit of time. eGFR below 60 may indicate kidney function problems. GGT Liver Test The gamma-glutamyl transpeptidase (GGT) blood test looks for an enzyme or protein by that name in your blood. GGT stands for gamma-glutamyl transpeptidase. GGT is present in the cells of the liver. Your doctor can use this test to check for liver damage or the ducts that drain it. If the results of another blood test, alkaline phosphatase, is abnormal this test can also help to differentiate between liver diseases and bone diseases. Higher than normal results may indicate liver damage from diseases like hepatitis, cirrhosis, tumors or pancreatic cancer. GGT is not affected by resistance training unlike other liver enzymes in the CMP like AST and ALT. So using GGT is a more accurate way to know if a bodybuilder has liver disease. Total testosterone was measured by liquid chromatography/mass spectrometry and free testosterone by equilibrium ultrafiltration. Since the standard total testosterone test by immunoassay has a ceiling of 1,500 ng/dL, men with high testosterone cannot use the test. Testosterone replacement therapy (TRT) in bodybuilding can have significant implications, especially when combined with intense training and anabolic steroid use. It is crucial to be aware of the health risks associated with TRT and to conduct regular blood tests to monitor hormonal and health changes. Measuring luteinizing hormone (LH) along with testosterone is important to understand hormonal imbalances and optimize training and supplementation. The LC/MS test for testosterone has no ceiling. Some labs also provide calculated free testosterone instead of equilibrium ultrafiltration-based one which is more accurate for this value. Ultra-Sensitive Estradiol (E2) Test The estradiol level may be overestimated by the test used. This test uses immunoassay technology which cannot distinguish between C-Reactive Protein (involved in inflammation) and estradiol; so it interprets the combination of the two as estradiol. This ultrasensitive estradiol test uses assay technology called liquid chromatography/mass spectrometry (LC/MS) which is not limited by the above mentioned limitation. DHT analogs like oxandrolone can significantly lower estradiol levels which can cause joint pain and other problems related to low estradiol. Notice that only 0.4% of total testosterone is converted to estradiol during aromatization. The body does this to counteract the beneficial effect of estradiol on lipids which is a result of testosterone’s negative effect on lipids. When your total testosterone is high your estradiol will also be high. When you assume an aromatase inhibitor is needed you should be very careful. Click the link to know the effect of high and low estradiol levels on men’s health. How to measure estradiol levels with different dosages of testosterone. Prolactin Test Prolactin levels are a concern for many bodybuilders because of the correlation with erectile dysfunction. DHT Test This test measures the amount of dihydrotestosterone (DHT) in the blood. In some men excessive levels of dihydrotestosterone (DHT) is linked to acne, hair loss and benign prostatic inflammation while low levels is linked to low libido. IGF-1 Test Insulin-like Growth Factor 1, also known as IGF-1 is measured to determine the amount of human growth hormone in the blood. This hormone controls the growth and metabolism of glucose and is produced by the liver and other tissues. Lack of IGF-1 will prevent muscle growth. Ferritin Test Iron is stored in the body via ferritin. Iron is needed for the formation of red blood cells which carries oxygen throughout the body. Lack of ferritin in the blood is anemia. TRT and anabolics increases the production of red blood cells in the body (erythrocytosis). Because of the increased production, iron reserves and ferritin levels decreased. Additionally, thyroid hormones play a crucial role in regulating metabolism, energy levels, and body composition, which are essential for bodybuilders. Testosterone decreases ferritin. Men who are on TRT or anabolics and have high hematocrit (thick blood due to TRT or anabolics) often donate blood or undergo phlebotomy. Every time you donate blood ferritin level drops by about 30 points on average. Low ferritin can cause various symptoms including tiredness, muscle aches and restless leg syndrome. Monitoring thyroid-stimulating hormone (TSH) is also important as part of a comprehensive evaluation of thyroid function for bodybuilders. TSH levels can significantly impact metabolism, energy levels, and overall performance. Hormones and Muscle Growth Hormones play a critical role in muscle growth and development. Understanding the role of hormones in bodybuilding can help bodybuilders optimize their training and nutrition strategies to promote muscle mass. Role of Hormones in Bodybuilding Hormones such as testosterone, growth hormone, and insulin-like growth factor-1 (IGF-1) are essential for muscle growth and development. Testosterone, in particular, is a key anabolic hormone that drives muscle growth and development in men. It promotes protein synthesis, which is crucial for muscle repair and growth after intense training sessions. Growth hormone and IGF-1 also play significant roles by stimulating muscle cell growth and increasing the uptake of amino acids into muscle cells. For women, oestrogen and growth hormone are important anabolic hormones that support muscle growth and development. By understanding the functions of these anabolic hormones, bodybuilders can tailor their training and nutrition strategies to maximize muscle mass and enhance performance. Blood Test Results Blood test results can be confusing especially for bodybuilders who are not familiar with medical terms. But understanding these results is key to making informed decisions on training and nutrition. A full blood test panel will give you insights on overall health and fitness including muscle growth, hormone levels and kidney function. By reading these results bodybuilders can adjust their training and nutrition plan to maximize performance and minimize health risks. Results When reading blood test results, always refer to the normal reference ranges for each biomarker. For example a testosterone level of 300-1000 ng/dL is normal for adult male. If the result is out of this range it means there’s an underlying issue that needs to be addressed. Bodybuilders should consult a healthcare professional to interpret their blood test results and create a plan to adjust their training and nutrition. This way any abnormality will be identified and managed immediately and overall health and performance will be supported. Nutrition in Bodybuilding Nutrition is a big part of bodybuilding and blood tests can give you insights on nutritional deficiencies or imbalances. A full metabolic panel can measure biomarkers such as glucose, electrolytes and liver enzymes which can tell you how well your body is utilizing nutrients. By knowing these markers bodybuilders can adjust their diet to make sure they are getting the necessary nutrients for muscle growth and recovery. How Blood Tests Affects Nutrition Decisions Blood tests can affect nutrition decisions by identifying potential deficiencies or imbalances. For example low vitamin D means you need to supplement or increase sun exposure. High cortisol means you need to reduce stress or adjust training and nutrition. By using blood test results to guide nutrition decisions bodybuilders can optimize their diet and training plan to support muscle growth and recovery. Blood tests can also help identify nutritional deficiencies that impact muscle recovery, emphasizing the importance of proper nutrition, supplementation, and adequate rest for effective muscle recovery and overall training success. This proactive approach will keep you at peak performance and overall health. Common Nutrient Deficiencies Nutrient deficiencies can negatively impact muscle growth and recovery. Common nutrient deficiencies in bodybuilders include iron, vitamin D, and magnesium deficiencies. Iron is essential for transporting oxygen to the muscles, which is vital for energy production during workouts. Vitamin D and magnesium are important for muscle function and recovery, helping to prevent muscle cramps and promote muscle relaxation. Protein is also essential for muscle growth and repair, but excessive intake can cause kidney damage. By regularly monitoring nutrient levels through blood tests, bodybuilders can identify deficiencies early and adjust their diet or supplementation accordingly. This proactive approach ensures that they are getting the necessary nutrients to support muscle growth, recovery, and overall health. By understanding the importance of blood tests and the role of hormones in bodybuilding, bodybuilders can make informed decisions about their training and nutrition strategies to optimize their performance and promote muscle growth. Regular blood tests can help bodybuilders detect any underlying health disorders and avoid potential health risks, ensuring that they can continue to train and compete at their best. How Often to Get Blood Tests Frequency and timing of blood tests depends on individual goals and circumstances. Bodybuilders on hormone replacement therapy (HRT) or anabolic steroids need to get blood tests more frequently to monitor hormone levels and potential side effects. Monitoring helps to adjust dosages and prevent adverse effects so that the benefits of these therapies are maximized while minimizing risks. How Often Should Bodybuilders Get Blood Tests? As a general rule bodybuilders should get blood tests at least once a year to monitor overall health and fitness. But bodybuilders on HRT or anabolic steroids should get blood tests every 3-6 months to monitor hormone levels and potential side effects. Bodybuilders who are experiencing symptoms like fatigue, muscle weakness or joint pain should get blood tests more frequently to identify underlying issues. Blood testing is a proactive measure to ensure any health concern is addressed immediately and long term health and performance is supported. Bodybuilder Blood Test Panel Available on DiscountedLabs.com Bodybuilder Blood Test Panel- Basic Bodybuilder Blood Test Panel- Beginner Bodybuilder Blood Test Panel- Comprehensive

How to Safely Use PCT After TRT: Stopping Testosterone Replacement Therapy Table of Contents What is Post Cycle Therapy PCT? Why Do Men Stop TRT? Common reasons a man may need to discontinue TRT include: Normalizing Natural Testosterone After Stopping TRT PCT Treatments to Jump Start Natural Testosterone and Sperm Production How to Know if Your PCT Worked? Buy Discounted Lab's Post-PCT Panel  References: There is a common phrase most men will hear when they consider testosterone replacement therapy (TRT); it may be something they hear from friends or often what they read online: “TRT is for life.” There is an element of truth to this statement: when a man has low testosterone, in order to treat it and maintain healthy or optimal levels, he will always need TRT to achieve it. However, saying “it's for life” remains a somewhat inaccurate statement, and this is where we enter into the realm of what is commonly referred to as Post Cycle Therapy or PCT. TRT and anabolic androgenic steroids (AAS) can lead to dysfunction in HPTA (Hypothalamic-Pituitary-Testicular Axis). Supplemental testosterone can inhibit the release of the body's own testosterone production through negative feedback inhibition on LH levels. This feedback inhibition also results in the suppression of FSH levels, leading to the suppression of sperm production (spermatogenesis). During recent years a large surge in testosterone prescriptions and TRT clinics has unfortunately led to many men who have been misdiagnosed with low testosterone yet placed on TRT when it may not have been needed in the first place. If you are one of these men and you are considering discontinuing testosterone treatments, some protocols can help restore your hormone axis. You do not want to stop testosterone "cold turkey," which will lead to unnecessary symptoms that could last for many months. Understanding TRT and Its Impact on the Body Testosterone Replacement Therapy (TRT) can be a game-changer for men with low testosterone levels, but it’s crucial to understand how it impacts the body. TRT involves introducing exogenous testosterone into the body, which can disrupt the natural hormone production process. To grasp the full picture, we need to explore the Hypothalamic-Pituitary-Testicular Axis (HPTA) and how TRT affects it. The Hypothalamic-Pituitary-Testicular Axis and TRT The Hypothalamic-Pituitary-Testicular Axis (HPTA) is a sophisticated system that regulates testosterone production. It starts with the hypothalamus, which produces Gonadotropin-Releasing Hormone (GnRH). This hormone signals the pituitary gland to release Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). LH and FSH then stimulate the testes to produce testosterone. When you undergo Testosterone Replacement Therapy (TRT), this delicate balance can be disrupted. The introduction of exogenous testosterone can suppress the body’s natural production of LH and FSH, leading to a decrease in the body’s ability to produce testosterone on its own. Impact of TRT on Natural Testosterone Production The impact of TRT on natural testosterone production can be significant. When exogenous testosterone is introduced, it can lead to a suppression of LH and FSH, which are crucial for natural testosterone production. This suppression can result in various symptoms, such as low libido, fatigue, and decreased muscle mass. Over time, prolonged use of TRT can lead to hypogonadism, a condition where the testes are unable to produce sufficient testosterone. This is why understanding the effects of TRT on natural hormone production is essential for anyone considering or currently undergoing TRT. What is Post Cycle Therapy PCT? PCT is a treatment plan after discontinuing anabolic androgenic steroids (AAS). It is a phrase most commonly associated with what we might call “recreational steroid users” (RSU), such as bodybuilders: people who do not need steroid hormones like testosterone for medical reasons but use them for muscular competition advantage. In such cases, the individual will supplement with AAS for a set period of time, known as a steroid cycle, and then discontinue use. As his use of AAS shut down his natural testosterone production, just as it does with TRT, he will often implement a PCT plan for natural production to restart. Such plans will include Selective Estrogen Receptor Modulators (SERMs) or other items, such as the peptide HCG. The goal for the RSU, as eluded to prior, is to regain his natural production of testosterone as quickly and efficiently as possible. There is no guarantee this will work. There is no guarantee he will reach his previous levels before AAS use, although perhaps levels that accurate enough. Then we have the TRT patient; such an individual had low testosterone levels before he began administering exogenous testosterone. The use of testosterone, just as it did with the RSU, will stop his natural production. This is a factor that bothers many men, but let us keep in mind a very significant one: you already had low levels, your body was not able to produce enough, to begin with, and was not going to be able to, or you wouldn’t be on TRT. Nonetheless, there are reasons some men may find they need to discontinue use, and when that occurs, a PCT plan may be in order. Such a plan will not address his primary issue, low testosterone, but the goal here is to get at least some natural production back online. Why Do Men Stop Testosterone Replacement Therapy? Common reasons a man may need to discontinue TRT include: Need for Fertility TRT Cost TRT Side Effects or Health Issues Of the three potential reasons to stop TRT, fertility is the overwhelming reason for most men. Along with suppressing natural testosterone production, TRT can also have a negative impact on sperm production. There was a time in history not that long ago when it was thought exogenous testosterone would be touted as a male contraceptive. This idea died out when many men using testosterone found they were still able to impregnate a female. While many men on testosterone were found to be severely lacking in this department, it wasn’t enough or significant enough to market the hormone as an actual contraceptive. The other common reasons for discontinuing TRT are cost and side effects. These are the least common reasons in comparison to fertility needs or desires, but both are still possible. We all go through points in life where money can get a little tight; loss of a job, unexpected expenses – whatever the reason, if you find you need to stop, considering a PCT plan with your physician will make the transition easier. You’re still going to have low testosterone levels in the end – remember, you already had them, or you wouldn’t have started TRT in the first place – but you’ll hopefully be in a better position than you would be without, and in time, when your situation improves, you’ll be able to jump back on your TRT plan. The same may hold true for the individual who has side effect issues. This will be the least common reason for discontinuation of TRT but certainly within the realm of possibility. You could be one of the rare individuals who cannot control his hematocrit even with regular therapeutic phlebotomy. You could be someone that has other health concerns and, for whatever reason, need to discontinue use until you figure out what’s going on with your body. Hormonal imbalances, such as elevated estrogen levels, can also occur when stopping TRT, leading to conditions like gynecomastia. As was with the individual who was experiencing income issues, a PCT plan may be in order. Preparing for TRT Discontinuation Deciding to discontinue TRT is a significant step and should be approached with caution. One of the most critical aspects of stopping TRT safely is to do so under the guidance of a medical professional. Abruptly stopping TRT can lead to severe withdrawal symptoms and a dramatic drop in testosterone levels, which can be detrimental to your health. Gradual Tapering Under Medical Supervision When it comes to discontinuing TRT, gradual tapering is the safest approach. This process involves slowly reducing the dosage and frequency of testosterone administration to allow the body to adjust and begin producing testosterone naturally again. A healthcare provider can create a personalized tapering schedule based on factors such as the dosage and duration of your TRT use. This might involve reducing the amount of testosterone you inject or apply through gels over a set period. Regular check-ups with your healthcare provider are crucial during this time to monitor your progress and make any necessary adjustments to your tapering plan. This careful and monitored approach helps minimize withdrawal symptoms and supports the body’s natural transition back to producing testosterone on its own. By understanding the impact of TRT on your body and following a medically supervised tapering plan, you can safely discontinue TRT and support your body’s return to natural testosterone production. Normalizing Natural Testosterone After Stopping TRT For most men, studies have shown that for men who stop TRT, natural testosterone production can normalize within three months or longer, and spermiogenesis in well over a year. This is certainly not optimal when conception is the goal, which leads to the possible need for a PCT protocol. Post cycle therapy (PCT) is crucial in maintaining and recovering natural testosterone levels after using performance-enhancing drugs, as it helps enhance the body's own testosterone production. PCT Treatments to Restore Hormonal Balance and Jump Start Natural Testosterone and Sperm Production The use of the SERMs has been shown to increase testosterone levels to baseline in as little as 2-4 weeks. Studies have also shown spermiogenesis to improve significantly within 3-6 months. Clomid as we can easily see, greatly improves the time frames of recovery of these two important factors related to conceiving (testosterone and semen). PCT is crucial to restore hormonal balance, helping individuals recover from the use of anabolic steroids by promoting natural testosterone production and mitigating adverse effects caused by hormonal imbalances. HCG is another item commonly used in PCT for fertility purposes. HCG PCT has the ability to stimulate both testosterone production and spermiogenesis. It is not uncommon for fertility specialists to try both Clomid and HCG and, in some cases, in conjunction with one another. Unfortunately, there is much controversy among many fertility specialists regarding how much HCG should be administered for this purpose. While many physicians will prescribe SERMs in the range of 25-50mg per day to every other day, commonly prescribed HCG doses can run anywhere from 1000iu per day to 2500iu or even larger doses split into every other day schedules. Other common drugs used in this treatment, but to a lesser extent, include the SERM Tamoxifen Citrate, best known by its most notable trade name, Nolvadex. Treatments usually requires 4 weeks. Unfortunately, for some men, a PCT plan that includes some or all of these medications will not work. A HCG PCT plan is most likely to work in a TRT patient who is receiving treatment due to secondary hypogonadism. If a PCT plan has not worked – testosterone levels and sperm count have not increased – it is likely that the individual has primary hypogonadism, and as a result, will be best served (quality of life) by remaining on TRT. It’s imperative to note: this individual had primary hypogonadism prior to beginning TRT, he did not obtain it because of TRT. How to Know if Your PCT Worked? After going through PCT, physicians tend to check your testosterone blood levels and upstream hormones like LH and FSH to determine if your hormone axis has been restored. Discounted Labs has created a Post PCT Lab Test Panel that makes it easy for men to know if their PCT has successfully worked. This lab test panel is designed to measure the health and recovery of the Hypothalamic-Pituitary-Testicular Axis (HPTA) after attempting to normalize it spontaneously or with the use of Post Cycle Therapy (PCT) (with the use of clomiphene, hCG, and other treatments) It is suggested that this panel be done no sooner than 4 weeks after PCT cessation and in a fasting state (morning time). Lab tests included in the post-PCTest Panel: Ultra Sensitive Estradiol Test by Liquid Chromatography/Mass Spectrometry (LC/MS assay used to measure estradiol in men more accurately estradiol in men) Total and Free Testosterone LC/MS- No upper limit Luteinizing Hormone (LH) (responsible for activating Leydig testicular cells to produce your own testosterone). This hormone is shut down by testosterone replacement or AAS. Follicle Stimulating Hormone (FSH) (Responsible for activating Sertoli testicular cells to produce sperm). This hormone is shut down by testosterone replacement or AAS. CBC - Complete Blood Count (Includes hematocrit- red blood cell volume) CMP - Comprehensive Metabolic Panel (Includes liver and kidney function, glucose and electrolytes) For any man, simply discontinuing the use of testosterone can be difficult, to put it mildly. Your testosterone levels will completely bottom out when going the cold-turkey route, and this often. This severe sexual dysfunction, decreased energy, and even depression, to name a few of the consequences. Your levels may go up enough to at least function, to a degree, but it's going to take an enormous amount of time, as previously discussed. Cutting this time down significantly, and giving your body a boost in testosterone during the therapy process, is the only means of discontinuation that makes any sense, meaning some form of a PCT plan is a sensible approach. Buy Discounted Lab's Post-PCT Panel  References: Diagnosis and Management of Anabolic Androgenic Steroid Use Testosterone Use in the Male Infertility Population: Prescribing Patterns and Effects on Semen and Hormonal Parameters How to Stop TRT Safely

Can Testosterone Make You Tired?  Some men start testosterone replacement therapy (TRT) to address low T and testosterone deficiency and find out their baseline fatigue and low energy get worse. Testosterone and Energy Levels Testosterone controls energy levels in men. When testosterone is within normal range, men feel more energetic and motivated. Testosterone supplementation can also help restore energy in men with low testosterone. Low testosterone can cause fatigue, lethargy, and feeling unwell. Testosterone helps regulate the body’s metabolism, which converts food into energy. Studies have shown that testosterone levels are related to energy levels. Men with low testosterone have lower energy levels; men with normal or high testosterone have higher energy levels. Testosterone replacement therapy also helps improve energy in men with low testosterone. By getting testosterone levels back to normal range, many men feel a big boost in overall energy and vitality. Why does TRT cause fatigue? TRT can cause fatigue in some men for the following reasons: Overstimulation of the body: Increased testosterone can overwork the body and cause fatigue and exhaustion. Insomnia: Some men on testosterone therapy may have difficulty sleeping and get fatigue. Hormonal imbalance: Sudden increase in testosterone can cause imbalance with other hormones in the body and cause fatigue and other symptoms. Side effects of the medication: Testosterone medication can cause side effects like acne, fluid retention, and mood changes, which can also cause fatigue. Testosterone injections, which are a common method of TRT, can cause these side effects. As testosterone levels drop, men may feel more fatigue and lower energy levels, which can be worsened by TRT. Note that testosterone therapy can also help improve energy and reduce fatigue in some men but it’s best to discuss the benefits and risks with a healthcare provider before starting treatment. If no improvement in fatigue is seen after 6 weeks of testosterone replacement, other factors beyond hypogonadism may be present. This article will review a few ways to find out what causes TRT fatigue. Low Testosterone Symptoms Low testosterone can cause many testosterone deficiency symptoms, including: Fatigue and lethargy Low sex drive Erectile dysfunction Loss of muscle mass and strength Increased body fat Decreased bone density Mood changes like depression and anxiety Difficulty concentrating and memory problems If you have any of these symptoms, consult a healthcare professional to find out if low testosterone is the cause. A proper diagnosis will help you explore treatment options, including testosterone replacement therapy, to alleviate these symptoms and improve your life. Thyroid Function and Hormonal Imbalance: The thyroid is a butterfly-shaped endocrine gland located in the lower front of the neck. It produces thyroxine or T4, which is converted to triiodothyronine or T3. T4 production is controlled by thyroid-stimulating hormone or TSH, which is produced by the pituitary. Hypothyroidism, or low thyroid hormone production, can cause sexual dysfunction and depression, fatigue, dry skin and hair, weight gain, and increased sensitivity to cold. Blood tests to measure TSH, T4, and T3 are available and widely used. The American Thyroid Association (thyroid.org) has great info on how to find out if you have hypothyroidism that’s causing your fatigue. Testosterone can decrease thyroxin-binding globulin and total T4 serum levels and increase resin uptake of T3 and T4. Free thyroid hormone levels remain the same and there’s no clinical evidence of thyroid dysfunction. Once thyroid hormone levels are normalized, testosterone tends to increase naturally. Check your thyroid hormones here: Choose Your Test | Discounted Labs   Adrenal Function and Chronic Fatigue: The adrenal glands are located in the abdomen above the kidneys and regulate stress in the human body. When the body is in an emergency situation, the adrenal glands release hormones like adrenaline to enable the body to respond. You may have experienced this reaction called the “fight or flight” response if you were in danger, fear, or shock. Adrenal fatigue is the controversial idea that the adrenal glands can get worn out and cause illness if continuously overstimulated. Proponents of the “adrenal fatigue” theory believe that the adrenal glands may be overworked in some individuals and therefore get “fatigued” and unable to produce enough hormones. When your adrenal glands are exhausted, your cortisol levels drop significantly. Cortisol is your natural stress hormone. Low sex drive and infertility are symptoms of adrenal fatigue. Other symptoms include chronic fatigue, low blood pressure and low blood sugar, dizziness, headaches, anxiety or panic attacks, depression, and other equally debilitating problems. Some doctors may prescribe low doses of corticosteroids if your morning cortisol levels (measured by blood, saliva, or urine tests) are low. But be careful with corticosteroids, as they can increase fat mass and decrease bone density if given in doses higher than what the healthy adrenals would produce. Check your adrenal health. DHEA and Testosterone Levels: The adrenal glands also produce dehydroepiandrosterone (DHEA), the most abundant hormone in the bloodstream. The body uses DHEA as the starting material to produce the sex hormones testosterone and estrogen in men. DHEA supplementation can increase DHEA levels, which in turn can support testosterone production. Studies show it only increases testosterone in women. DHEA production decreases in most people after age 40. In people 70 years old, DHEA levels will be 30% lower than what they were at age 25. Low DHEA levels are associated with many degenerative conditions. Some studies are controversial and inconclusive that people with immune deficiencies and fatigue may benefit from supplementation with this hormone. It’s still available over-the-counter in the US. This may change soon, as a new bill was passed by Congress classifying it as a performance-enhancing steroid (no studies show it has such an effect). One study showed that women with normal DHEA levels can convert it into testosterone as their body needs while men don’t benefit the same way. You need a blood test to know if you have low DHEA-S since most of the DHEA converts into this sulfated form. Common doses for women are 5-30 mg a day, while men benefit from 25-100 mg a day (to bring low DHEA-S to normal). NOTE: Do not use DHEA supplements unless your blood levels of DHEA-S are low. If low, start at a low dose and get your DHEA-S tested again after a month. Men who use DHEA supplements may have problems with higher estrogen levels since DHEA can also convert into estradiol. This can cause gynecomastia and water retention. If you start taking DHEA, get your blood levels checked to make sure they are not above normal. There are many claims about DHEA being an anti-aging and anti-cancer cure but none of these claims have been proven with strong data. To make diagnosis easier, we have created this new Fatigue Panel on DiscountedLabs.com at a discount. Click here: Comprehensive Fatigue Panel Sleep Apnea: Sleep apnea is a sleep disorder in which a person stops breathing or breathes shallowly many times during sleep and therefore doesn’t get enough restful sleep; oxygen levels in the blood drop and the brain starves of oxygen. Besides causing daytime fatigue, it can increase blood pressure and cardiovascular risks. Testosterone replacement therapy has been linked to the worsening of sleep apnea or the development of sleep apnea, especially in men who use higher doses of testosterone or who have other risk factors for sleep apnea (high body weight, thick necks, snoring, alcohol consumption, etc.). Upper-airway narrowing doesn’t seem to be caused by testosterone replacement therapy; it suggests that testosterone replacement contributes to sleep-disordered breathing by central mechanisms rather than by anatomical changes in the airway. Tell your doctor if your spouse or partner complains that you snore loudly at night and feel fatigued. The only way to know for sure if you have sleep apnea is to have your doctor refer you to a sleep lab for a sleep study. If you are diagnosed with sleep apnea, a continuous positive airway pressure (CPAP) machine can be prescribed to help open up your airways with a small air pump while you sleep. Some people love it; some hate wearing a mask while being hooked up to a machine at night. I have seen men regain their quality of life after starting CPAP. It’s covered by insurance, Medicare, and most HMOs. A new option for those who hate CPAP machines with mild to moderate apnea is the use of oral appliances. Worn in the mouth like an orthodontic appliance during sleep, oral appliances keep the soft tissue from collapsing and interrupting normal breathing patterns. The purpose of the oral appliance may be to reposition the lower jaw, tongue, soft palate, and hyoid bone into a certain position; to keep the airway open with stabilization of the tongue and jaw; or to provide artificial muscle tone to prevent collapse and resulting airway blockage. The doctors will fit your oral appliance for comfort by using a mold of your mouth to design your unique fit. Fatigue Management with Testosterone Therapy Testosterone therapy can help manage fatigue in men with low testosterone. Testosterone gel is another way to get testosterone therapy to help manage fatigue. Testosterone therapy can bring many health benefits, including improved cardiovascular health, better blood sugar control and reduced risk of osteoporosis and diabetes. But it’s important to understand the benefits and risks of testosterone therapy and to discuss them with your doctor. Some men will experience a big boost in energy and overall well-being; others will find their fatigue persists or even worsens. This variability is why personalized medical advice and regular monitoring are important to tailor the treatment to your needs. Energy Tips In addition to testosterone therapy, there are several lifestyle changes that can help men regain energy and overall health. These are: Regular Exercise: Strength training and cardio exercises can help build muscle and boost energy. Exercise also helps with better sleep and reduces stress, which can further increase energy. Healthy Diet: Eating a balanced diet rich in protein, healthy fats, and complex carbohydrates can give you energy all day. Lean meats, fish, nuts, seeds, and whole grains are good choices. Sleep: Aim for 7-9 hours of sleep per night to help regulate testosterone and energy. Good sleep hygiene practices like a consistent sleep schedule and a restful environment can make a big difference. Stress Management: Meditation, yoga, or deep breathing exercises can help manage stress, which can help increase energy. Chronic stress can lower testosterone so finding ways to cope is important. Hydration: Drinking plenty of water throughout the day is key to maintaining energy and overall health. Dehydration can cause fatigue and decreased physical performance. Natural Testosterone Boosters While testosterone replacement therapy may be needed for some men, there are also natural testosterone boosters that can increase testosterone. These are: Exercise Regularly: Exercise, especially weightlifting and high-intensity interval training, can increase testosterone. Eat a Healthy Diet: A diet rich in protein, healthy fats, and complex carbohydrates can support testosterone. Get Enough Sleep: Sleep is key to testosterone production so aim for 7-9 hours of sleep per night. Reduce Stress: High stress can lower testosterone so find ways to manage stress through meditation or yoga. Get Enough Vitamin D: D: Vitamin D is important for testosterone production, so make sure you get enough through sun exposure, supplements, or fortified foods. Implementing these lifestyle changes can support your body’s natural testosterone production, and if you’re already on testosterone replacement therapy,. Testosterone Therapy Risks and Considerations Testosterone therapy can be good for men with low testosterone, but there are testosterone side effects and considerations to be aware of: Blood Clots and Stroke: Testosterone therapy can increase the risk of blood clots, which can cause stroke or other cardiovascular events. Cholesterol and Cardiovascular Health: Testosterone therapy can affect cholesterol levels, which can increase heart disease risk. Lipid profiles should be monitored regularly. Fertility and Sperm Production: Testosterone therapy can reduce sperm production. Men who want to have children should talk to their doctor. What to Expect from Testosterone Men on testosterone therapy can expect: Increased Energy and Reduced Fatigue: Many men feel more energetic and less fatigued after starting testosterone therapy. More Muscle and Strength: Testosterone therapy can increase muscle mass and strength for better physical performance and overall health. Better Bone Density: Testosterone therapy can increase bone density, reducing the risk of osteoporosis and fractures. Libido and Sexual Function: Many men experience improved libido and sexual function, which can improve their quality of life. Overall Well-Being: Testosterone therapy can improve mood and overall sense of well-being for better quality of life. But you need to have realistic expectations and understand that testosterone therapy is not a magic pill. It may take several months to see the full effects and regular monitoring and adjustments may be needed to get the best results. Testosterone Monitoring Monitoring testosterone levels is crucial to ensure treatment is working and to minimize side effects. This means working with a healthcare professional to track progress and adjust therapy. Why Blood Tests Blood work is needed to monitor testosterone levels and adjust treatment. These tests can: Confirm Diagnosis: Blood tests can confirm low testosterone levels so testosterone therapy is appropriate. Monitor Results: Testing helps to monitor testosterone therapy and ensure testosterone levels are in range. Identify Side Effects: Blood tests can detect side effects like changes in cholesterol or liver function so treatment can be adjusted. Healthy Ranges: Keeping testosterone levels in a healthy range is key to minimizing risk and maximizing benefits. You need to work with a healthcare professional to determine the best testing schedule and to make sure testosterone levels are being monitored regularly. This proactive approach will get the best results and overall health. Get your own testosterone test here. When to See a Doctor for Fatigue If you have persistent or severe fatigue, you need to see a doctor. Fatigue can be a sign of an underlying medical condition like low testosterone, anemia, or diabetes. A healthcare professional can help figure out what’s causing your fatigue and develop a plan to treat it. If you have any of the following, see a doctor: Fatigue that lasts more than 2 weeks Severe fatigue that affects daily activities Fatigue with other symptoms like weight loss, fever, or night sweats Fatigue that doesn’t go away with rest or sleep A healthcare professional can do a physical exam, take a medical history and order diagnostic tests like blood work to figure out what’s causing your fatigue. Knowing the cause is key to developing a treatment plan and overall health and wellness. References Here are the clickable links with their corresponding titles: Can Testosterone Replacement Therapy Cause Insomnia? TRT and Fatigue: Understanding the Connection and How to Overcome It Testosterone Therapy: Effects and What to Expect Experiencing Extreme Tiredness and Fatigue on TRT? Can Testosterone Therapy Make Me Less Tired? Addressing Fatigue with Testosterone Pellets

Pregnenolone for Men: An Overview of this Neurosteroid and Men’s Health Pregnenolone is a steroid hormone and natural steroid in the human body and has recently been in the spotlight in medical research, especially when it comes to men’s health. Low pregnenolone levels can cause muscle loss in aging men. This article will look into different studies that are looking into the role of pregnenolone, including the administration of pregnenolone for brain function, hormone balance, and how it can be used to treat schizophrenia. By looking into research papers, we will give you an overview of how pregnenolone affects men’s health. What is the neurosteroid pregnenolone? You could say pregnenolone is the “father” of all hormones! Your body makes hormones from cholesterol, the sterol lipid molecule made in our liver. But your body has to go through a process to make hormones like testosterone, estrogen, DHT, and so on. First it has to convert the cholesterol into pregnenolone, the mother of all hormones. From there it can make progesterone (where cortisol comes from) and DHEA (which is needed to make testosterone). This process is important because pregnenolone is a precursor to testicular steroid hormones, including testosterone, which are important for reproductive health and male sexual function. The synthesis of testicular steroid hormones happens in the mitochondria, where pregnenolone is produced and then converted into testosterone and other hormones. This process is important for overall hormonal balance and has big implications for reproductive health. But that first step (converting cholesterol into pregnenolone) is the most important step. Pregnenolone is the precursor to all these other hormones, as you can see in the chart below: In a young adult male, pregnenolone levels are at their peak. But as you age, the levels of this precursor hormone drop and the body’s response to it. At 75 years old, our body produces only 40% of the pregnenolone it needs. That’s a big drop in the precursor hormone, which means a big drop in all the hormones derived from pregnenolone. Before we get into the studies, let’s first understand what pregnenolone is and its basics. Pregnenolone is often referred to as a neurosteroid; it’s a precursor to many other steroids, including testosterone. It’s produced in the adrenal glands, brain, and gonads. This neurosteroid plays a big role in synaptic plasticity, cognitive function, and mood regulation. Definition and Biochemical Profile of Pregnenolone Pregnenolone is a naturally occurring steroid hormone in the human body produced primarily in the adrenal glands, brain, and gonads. It’s produced from cholesterol through the action of the enzyme cholesterol desmolase. This process converts cholesterol into pregnenolone, which then becomes a precursor to many other steroid hormones. Pregnenolone is lipophilic, meaning it can easily cross cell membranes, including the blood-brain barrier, so it can exert its effects all over the body. Its biochemical profile is characterized by its ability to be converted into other steroid hormones such as testosterone, progesterone, and cortisol through a series of enzyme-catalyzed reactions. This versatility is the reason why it’s important for many physiological functions. Role of Pregnenolone in the Body Pregnenolone plays a big role in many physiological processes, including stress response, mood regulation, and immune system modulation. As a precursor to other steroid hormones like testosterone, progesterone, and cortisol, pregnenolone is important for overall hormonal balance. As a neurosteroid, it’s especially important for cognitive health. Research has shown that pregnenolone can improve memory, protect against neural degeneration, and potentially improve focus and mental clarity. Pregnenolone also supports overall hormonal balance, which is important for overall health and well-being. By being a precursor to other steroid hormones, pregnenolone regulates many bodily functions, from stress response to reproductive health. Pregnenolone for Men: Supplementation Routes and Doses Pregnenolone can be administered orally, subcutaneously, intravenously, intranasally, topically, or transdermally. Oral pregnenolone has high metabolism and low bioavailability. It’s lipophilic and can cross the blood-brain barrier. There is very limited data on the pharmacokinetics of exogenous pregnenolone. When taken orally, allopregnanolone breaks down pregnenolone faster than other hormones made from pregnenolone substrates like cortisol or DHEA. One study showed that 3 hours after oral intake of 400 mg of pregnenolone, pregnenolone serum levels increased by 60%. 2 hours after that, allopregnanolone serum levels tripled. Another study showed that a single oral dose of 175 mg of pregnenolone doubled pregnenolone serum levels for 4-8 hours. One study by Marx et al. (2009) looked at the effects of exogenous pregnenolone in patients with schizophrenia or schizoaffective disorder. Participants were given 8 weeks of oral pregnenolone with an escalating fixed dose, 500 mg for the last 4 weeks. Pregnenolone and downstream metabolites were measured in the serum. Pregnenolone sulfate was 3x higher, allopregnanolone was 5x higher and serum pregnenolone was 4x higher when taken orally. Oral pregnenolone also increased progesterone in the blood by 4x and DHEAS by 16%. Exogenous pregnenolone did not increase serum testosterone, free testosterone, cortisol, DHEA, estradiol, or androstenedione. Pregnenolone and Allopregnanolone in Anxiety: Pregnenolone is a hormone in the human body and is the precursor to allopregnanolone. This is important because allopregnanolone regulates mood and emotional states through the central nervous system and the body’s stress response. Higher levels of allopregnanolone have been linked to reduced anxiety symptoms. This anxiolytic effect shows the hormone’s impact on mental health. Blocking or inhibiting allopregnanolone can have negative effects on social and affective functioning. So if allopregnanolone production or activity is slowed down, it can make it harder to interact with others and control your emotions. This is how important the hormone is for mental health and social well-being. Have you ever wondered how your brain handles emotions, especially during stress or anxiety? This has been a question for scientists for a long time. A recent study looked into the role of a neurosteroid called allopregnanolone in emotional regulation. This is a calming substance and has been linked to anxiety reduction. But how it affects our brain’s emotional control circuits has been a mystery until now. To better understand allopregnanolone’s role, researchers did an innovative experiment. They gave 400 mg of pregnenolone (a precursor to allopregnanolone) to 16 participants and a placebo to 15 others. The participants then did a brain scan (3T fMRI) while doing the Shifted-Attention Emotion Appraisal Task (SEAT). This task is designed to measure emotional processing and regulation. The results were interesting. Compared to the placebo group, the allopregnanolone group had reduced activity in two brain regions: the amygdala and the insula. These areas are responsible for generating negative emotions like fear and anxiety. Allopregnanolone made the dorsomedial prefrontal cortex work harder during the emotion judgment part of the task. This is the part of the brain that controls emotions. It also increased the connection between the amygdala and this region. This was correlated with lower self-reported anxiety in the participants. Pregnenolone in Schizophrenia Treatment Several studies have looked into the use of pregnenolone in schizophrenia, a mental disorder characterized by cognitive and mood disturbances. For example, Marx et al. (2014) did a randomized controlled trial to test the efficacy of pregnenolone in schizophrenia. They found some improvement in cognitive functions and symptom reduction. Marx et al. (2009) also looked into the effects of pregnenolone on cognitive and negative symptoms in schizophrenia. This proof-of-concept study confirmed the potential of pregnenolone in improving cognitive functions in schizophrenia patients. Ritsner (2010) gives a broader view of pregnenolone, dehydroepiandrosterone (DHEA), and their changes in schizophrenia. This study tells us a lot about the hormone changes in men with schizophrenia so the potential therapeutic role of pregnenolone is even clearer. Cognitive Function and Mood Enhancements Beyond schizophrenia, pregnenolone’s role in general cognitive health and mood improvement has been looked into, especially in relation to promoting deep sleep. Osuji et al. (2010) studied the effects of pregnenolone on cognition and mood in dual-diagnosis patients. Their study suggested the potential of pregnenolone to improve cognitive function and mood but only in a specific patient group. Hormonal Effects in Men The hormonal effects of pregnenolone, especially on testosterone and total testosterone, have been studied. Pregnenolone is converted into testosterone in the testes and changes in pregnenolone levels can affect overall reproductive health and male sexual function. In 2023, Bracci et al. looked into the changes in pregnenolone and testosterone in male shift workers. This study showed how work schedules can affect hormonal balance. Their results showed the importance of pregnenolone in maintaining hormonal balance for sexual health. Pregnenolone in Age-Related Hormonal Changes Morley (2013) reviewed the role of pregnenolone in age-related hormonal changes, specifically on rejuvenation and vitality. His overview of hormone treatments for rejuvenation mentions the importance of pregnenolone in maintaining hormonal balance as men age. Pregnenolone’s role in synaptic plasticity Synaptic plasticity is a term in neuroscience, the study of the brain and nervous system. To understand it, think of your brain as a network of roads, where each road is a connection between brain cells (neurons). These roads are called synapses. Think of these roads as changeable. Some can become wider or more used, making the travel (or communication) between brain cells faster and stronger. Others can become less used or even disappear. This changing nature of the roads (synapses) is what we call synaptic plasticity. This is like learning and memory in the brain. When you learn something new or remember something, the roads in your brain adjust. Some connections become stronger because you use them more (like practicing a skill), and others weaken because you use them less. So, synaptic plasticity is the brain’s ability to rewire itself based on experiences, learning, and memory. It’s why we can learn new things and remember them. This flexibility is important for our brain’s growth and adaptation throughout our lives. Smith et al. (2014) reviewed the role of pregnenolone in synaptic plasticity. Their study showed the role of neurosteroids in modulating synaptic plasticity, which has implications for cognitive functions and mental health. One of the important findings of Dr. Smith’s team was that pregnenolone helps brain cells communicate, especially in ways that are important for learning and remembering things. This communication happens through something called the N-methyl-D-aspartate receptor (NMDAR), which is like a tiny receiver on brain cells that helps them talk to each other. These scientists found that pregnenolone can move these NMDARs to where they’re needed on the brain cell surface. It does this with the help of calcium ions (tiny particles) and G-protein-coupled receptors. Also, pregnenolone can increase the levels of calcium inside brain cells, which is really important for strengthening brain cell connections. This strengthening is what helps us learn and remember things. Testosterone Replacement Therapy and Anabolics Decrease Upstream Hormones like Pregnenolone To fully understand pregnenolone’s effects, we also need to understand its relationship with testosterone and other steroid precursors. In 1985, Ruokonen et al. studied how serum testosterone and its precursor steroids responded to anabolic steroids and testosterone administration. This study gave us a basic idea of how pregnenolone works with other hormones. High doses of testosterone and anabolic steroids were used for 26 weeks by power athletes and then stopped for 16 weeks. During the 26 weeks of steroid use, SHBG and CBG in their blood changed. After 16 weeks of follow-up, serum testosterone and androstenedione increased (P < 0.05), but pregnenolone, 17-hydroxypregnenolone, dehydroepiandrosterone, 5-androstene-3 beta, 17 beta-diol, progesterone, and 17-hydroxyprogesterone decreased (P < 0.001). Pregnenolone, 17-hydroxypregnenolone, and dehydroepiandrosterone sulfate in the blood and free steroids changed, but 5-androstene-3 beta, 17 beta-diol, and testosterone sulfate remained the same during follow-up. During drug use, SHBG decreased by 80-90% and remained low for 16 weeks after steroid withdrawal. Steroids had no effect on serum CBG. In summary, taking testosterone and anabolic steroids by themselves messed up the testicular endocrine system. Low levels of testosterone precursors, a high ratio of testosterone to its precursor steroids and low SHBG were the indicators of this. Low levels of SHBG and testicular steroids were still present during the 16 weeks after drug withdrawal. If dehydroepiandrosterone and its sulfate are low in the blood, it means anabolic androgenic steroids also stop the adrenal glands from producing androgens. Pregnenolone Side Effects Now, as with any hormone, there are downsides to pregnenolone supplementation. Not everyone will experience side effects but most users report one or more of the following: Bloating—Many pregnenolone users have reported feeling bloated and puffy with regular use even when taken with DHEA or other steroid hormones. This may be because pregnenolone increases the production of ALL sex hormones, including estradiol (the precursor to estrogen). An increase in estrogen can cause water retention and bloating. High Estrogen Levels—As mentioned above, pregnenolone is converted into all sorts of sex hormones, including various forms of estradiol. This increase in estradiol can raise your estrogen levels. Weird Dreams—Many people taking pregnenolone have reported weird dreams after taking the supplement. While pregnenolone can reduce anxiety and stress (as above), it can make your brain overactive when you sleep and may cause weird dreams. Other Side Effects -- According to WebMD, "There isn't enough information to know if pregnenolone is safe when taken by mouth." However, it can cause effects similar to other steroid hormones: arrhythmia, hair loss, facial hair growth, headaches, mood changes, acne, anger, anxiety, irritability, and insomnia. For those with hormone-sensitive conditions (breast, ovarian, or uterine cancer, endometriosis), the hormone may exacerbate health problems since pregnenolone increases estrogen production. But the truth is, these side effects are really minimal. Pregnenolone is generally a safe supplement with limited side effects. Just be aware of what you're getting into when taking pregnenolone. Pregnenolone Safety and Side Effects Pregnenolone is generally safe but be aware of the side effects, especially with high doses or long-term use. Common side effects may include headaches, dizziness, and nausea. Consult with a healthcare provider before taking pregnenolone, especially if you're taking other medications or have underlying health conditions. Pregnenolone can interact with certain medications like hormone replacement therapy, blood thinners, or immune system modulators, which may alter their effectiveness or increase the risk of side effects. Getting proper medical guidance can minimize these risks and ensure safe and effective use of pregnenolone. How Much Pregnenolone Do You Need? If you're taking it to increase natural hormone production, you need to know HOW MUCH to take. You don't want to overdo it and end up with side effects! According to the Quest Diagnostics Manual: Men: 10 to 200 ng/dL Women: 10 to 230 ng/dL Children: 10 to 48 ng/dL Adolescent boys: 10 to 50 ng/dL Adolescent girls: 15 to 84 ng/dL Mean levels of pregnenolone don't differ significantly in postmenopausal women and elderly men (40 and 39 ng/dL, respectively). The typical dose of pregnenolone is 50 to 200 mg per day taken first thing in the morning. The pills are to be taken on an empty stomach or you can use a cream (transdermal application). But you may want to consult with your endocrinologist for professional medical advice before taking any pregnenolone. They may recommend a higher or lower dose depending on your pregnenolone levels or may advise against it, especially if you have underlying health conditions like cardiovascular diseases. Get a recommendation from a medical professional before taking any supplement, especially hormones like pregnenolone. BUY PREGNENOLONE TEST Questions About Pregnenolone for Men Does pregnenolone increase testosterone? Pregnenolone is a hormone that's a precursor to other hormones, including testosterone. While pregnenolone itself doesn't increase testosterone levels, it can play a role in the body's production of testosterone and other hormones. The effect of pregnenolone on testosterone levels may vary from person to person and depends on individual hormonal balance, overall health, and dosage. Consult with a healthcare provider or endocrinologist for personalized advice on hormone levels and supplementation. Does pregnenolone work for erectile dysfunction? Pregnenolone is a hormone that's being used as a supplement for various health conditions but has not been scientifically proven to treat erectile dysfunction. If you have erectile dysfunction, consult with a healthcare provider or a doctor who can give you options based on your individual health and situation. How does pregnenolone compare to other supplements men use for hormonal balance? Pregnenolone is a hormone that's a precursor to other hormones like testosterone, estrogen, and cortisol. When it comes to hormonal balance in men, pregnenolone has a unique role compared to other supplements used for this purpose. While supplements such as DHEA and testosterone boosters target specific hormones, pregnenolone serves as a building block for various other hormones in the body. This means pregnenolone can support overall hormonal balance by providing the raw material for hormone production. Consult with a healthcare provider before adding any new supplement to your regimen, especially when it comes to hormonal health. Where to buy Pregnenolone for Men? Pregnenolone for men can be found at health food stores, pharmacies, online supplement retailers, and some medical or wellness clinics. Make sure to buy from a reputable source to ensure quality and efficacy. Before starting any new supplement regimen, consult with a healthcare provider to determine the right dosage and if it's safe for your health needs. Buying Guide: What to Look For When choosing a pregnenolone supplement, consider the following factors to get a high-quality product. Look for supplements from reputable companies that have third-party testing for purity and potency. Check the dosage to match your individual needs and health goals. Also check the manufacturing standards of the product and opt for GMP. Consult with a healthcare provider before starting any supplement regimen, especially if you have underlying health conditions or are taking other medications. This will help you choose the right supplement and dosage for your needs. Research on pregnenolone shows its many roles in men's health, especially in cognitive function, mood regulation, and hormonal balance. While it shows promise in treating schizophrenia and improving cognitive and mood functions, more research is needed to fully understand its therapeutic potential and long-term effects. Buy your own pregnenolone test here. References Marx, Christine E. et al. “Proof-of-Concept Randomized Controlled Trial of Pregnenolone in Schizophrenia.” Psychopharmacology 231.17 (2014): 3647–3662. Bracci, Massimo et al. “Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers.” International journal of environmental research and public health 20.4 (2023): 3195-. MARX, Christine E et al. “Proof-of-Concept Trial with the Neurosteroid Pregnenolone Targeting Cognitive and Negative Symptoms in Schizophrenia.” Neuropsychopharmacology (New York, N.Y.) 34.8 (2009): 1885–1903. Osuji, I. Julian et al. “Pregnenolone for Cognition and Mood in Dual Diagnosis Patients.” Psychiatry research 178.2 (2010): 309–312. Ritsner, Michael S. “Pregnenolone, Dehydroepiandrosterone, and Schizophrenia: Alterations and Clinical Trials.” CNS neuroscience & therapeutics 16.1 (2010): 32–44. Morley, John E. “Scientific Overview of Hormone Treatment Used for Rejuvenation.” Fertility and sterility 99.7 (2013): 1807–1813. Smith, Conor C., Terrell T. Gibbs, and David H. Farb. “Pregnenolone Sulfate as a Modulator of Synaptic Plasticity.” Psychopharmacology 231.17 (2014): 3537–3556.

Are you experiencing irregular periods, weight gain, or excessive hair growth? It could be a sign of Polycystic Ovary Syndrome (PCOS) and the need for weight loss. In this blog, we will delve into the world of PCOS and help you understand its symptoms and how they can affect your daily life. We will also discuss the importance of early detection and diagnosis, as well as how lifestyle changes, including weight loss, can help manage the symptoms. If you're wondering whether you should take this PCOS symptoms quiz, keep reading! We'll provide all the information you need to evaluate your own symptoms and determine if further investigation is necessary. Plus, we'll touch on the difference between PCOS/PCOD and endometriosis. Take control of your health and find out if PCOS could be impacting your life. Understanding PCOS: An Overview PCOS, also known as Polycystic Ovary Syndrome, is a hormonal disorder that affects many women. It is characterized by symptoms such as irregular periods, weight gain, acne, and excess hair growth. This condition can lead to fertility issues and an increased risk of other health conditions like diabetes and heart disease. Women with PCOS also have an increased incidence of Hashimoto’s thyroiditis, an autoimmune condition that is the leading cause of hypothyroidism. Hypothyroidism makes PCOS symptoms worse by slowing the metabolism, increasing insulin resistance, and affecting the mood. The diagnosis of PCOS involves a combination of physical exams, medical history, and blood tests. Treatment options for PCOS include lifestyle changes, medication, and, in some cases, surgery. Seeking medical advice is important if you suspect you may have PCOS, as early detection and treatment can help manage symptoms and prevent complications. Symptoms of PCOS: Identifying the Telltale Signs Identifying the telltale signs of PCOS is crucial for early detection and management. One common symptom is irregular periods, which can manifest as infrequent or absent menstrual cycles. Additionally, women with PCOS may experience excessive hair growth on their face, chest, or back due to hormonal imbalances, including facial hair. Acne breakouts are also prevalent in individuals with PCOS, further highlighting the impact of hormonal imbalance. Weight gain or difficulty losing weight is another symptom that many women with PCOS face, making it crucial to address lifestyle changes and nutrition. The presence of multiple cysts on the ovaries is a defining characteristic of PCOS. Moreover, PCOS can cause fertility issues, making it harder to conceive. By recognizing these symptoms, individuals can take the necessary steps towards diagnosis and treatment. How Do These Symptoms Affect Your Daily Life? PCOS symptoms can have a significant impact on daily life, both physically and emotionally. Irregular periods, excessive hair growth, and acne can affect self-esteem and body image. Fatigue and mood swings may impact productivity and overall well-being. Managing symptoms through lifestyle changes and medical treatments can improve daily life, including the health of hair follicles. The Importance of Early Detection and Diagnosis of PCOS Early detection and diagnosis of PCOS (Polycystic Ovary Syndrome) are crucial for managing symptoms and preventing long-term health complications. This common hormonal disorder affects women of reproductive age and can lead to a variety of physical and emotional challenges. Taking a symptoms quiz can help identify common signs of PCOS, such as irregular periods, acne, and weight gain. Once identified, seeking medical advice and getting a proper diagnosis from a healthcare professional are necessary for effective treatment. The exact cause of PCOS is not fully understood, but it is believed to be related to hormonal imbalances and genetics. Treatment options for PCOS include lifestyle changes, medications, and, in some cases, fertility treatments. Regular check-ups and monitoring can help manage PCOS symptoms and reduce the risk of related health conditions like diabetes and heart disease. By detecting and diagnosing PCOS early, women can take control of their health and improve their overall well-being, preventing many unwanted symptoms of PCOS. How is PCOS Diagnosed by Healthcare Providers? To diagnose PCOS, healthcare providers consider symptoms, perform physical exams, and review medical histories. Blood tests measure hormone levels and rule out other conditions. Ultrasound imaging checks for ovarian cysts. Accurate diagnosis and appropriate treatment, including birth control, require consultation with a PCOS specialist. Can Lifestyle Changes Help Manage PCOS Symptoms? Lifestyle changes play a crucial role in managing PCOS symptoms. By maintaining a healthy weight through diet and exercise, hormone levels can improve, leading to a reduction in symptoms. A balanced diet, stress management, and regular physical activity also contribute to better overall well-being. Who Should Take This PCOS Symptoms Quiz? If you suspect you may have PCOS, this symptoms quiz is for you. It is beneficial for women with irregular cycles, excessive hair growth, or difficulty getting pregnant. Individuals with a family history of PCOS or related conditions should also consider taking this quiz to raise awareness and seek medical advice if necessary. Inflammation and PCOS Symptoms Inflammation plays a significant role in PCOS, affecting women of reproductive age. The common symptoms of PCOS include irregular periods, acne, excessive facial and body hair growth (hirsutism), weight gain, and fertility issues. Insulin resistance, hormonal imbalances, and the presence of cysts on the ovaries are just a few causes of inflammation in PCOS. Androgens are known to contribute to the hormonal imbalances that lead to inflammation in PCOS. Metabolism also plays a crucial role in PCOS, as it affects the body's ability to regulate hormones and manage inflammation. Making lifestyle changes, including regular exercise and a healthy diet, can help improve metabolism and reduce inflammation in PCOS. Specific dietary recommendations for managing inflammation may include consuming anti-inflammatory foods and avoiding processed and sugary foods. The long-term health implications of inflammation and metabolism in PCOS include an increased risk of cardiovascular disease and endometrial cancer. Taking proactive steps to manage inflammation and improve metabolism can improve overall health and well-being. Take Our PCOS Symptoms Quiz To Evaluate Your Own Symptoms Take our PCOS quiz today and evaluate your own symptoms to gain insights into whether you may have PCOS-related inflammation and determine your next steps. Our carefully designed quiz consists of 8 questions that specifically assess the presence of inflammation symptoms associated with PCOS, including gluten sensitivity. By understanding and recognizing these symptoms, you can take proactive steps towards managing your health. It's important to note that inflammation symptoms, including gluten sensitivity, can be indicative of PCOS, a condition characterized by hormonal imbalances and various physical symptoms such as irregular periods, acne, weight gain, and hair loss. Our quiz serves as a helpful tool to assess your symptoms and determine if further medical evaluation is necessary. Take the PCOS quiz now and learn more about the potential presence of inflammation symptoms, including gluten sensitivity, in your body. How Do I Know if I Have Polycystic Ovary Syndrome? Signs of PCOS include irregular periods, excess hair growth, acne, weight gain, and menstruation. Diagnosis involves physical exams, a medical history review, and hormone tests. Consult a healthcare professional if you suspect PCOS. Treatment options may include lifestyle changes, medication, and fertility treatments. PCOS/PCOD vs. Endometriosis PCOS and endometriosis are two common gynecological conditions that can cause similar symptoms. PCOS (Polycystic Ovary Syndrome) is a hormonal disorder that affects the ovaries and can lead to irregular periods, infertility, and other symptoms. Endometriosis, on the other hand, is a condition where tissue similar to the lining of the uterus grows outside of the womb and can cause chronic pelvic pain, painful periods, and fertility issues. While both conditions can have overlapping symptoms, they have different underlying causes and require different treatment approaches. It is important to consult with a healthcare professional if you experience symptoms associated with either PCOS or endometriosis to receive an accurate diagnosis and appropriate treatment. Effect of PCOS on Fertility Polycystic Ovarian Syndrome (PCOS) is a common hormonal disorder that affects women of reproductive age. One of the significant impacts of PCOS is its effect on fertility. Women with PCOS often experience irregular menstrual cycles, which can make it challenging to conceive. The hormonal imbalances associated with PCOS can lead to issues with ovulation, making it difficult for eggs to mature and be released regularly. This can result in infertility or difficulty getting pregnant. Furthermore, women with PCOS are at a higher risk of developing insulin resistance, which can lead to high levels of insulin in the blood. Elevated insulin levels can disrupt normal hormone production and contribute to difficulties in conception. Additionally, the presence of excess androgens (male hormones) in women with PCOS can interfere with the development and release of eggs from the ovaries. Managing PCOS through lifestyle changes, such as maintaining a healthy weight, exercising regularly, and following a balanced diet, can help improve fertility outcomes. In some cases, medications such as oral contraceptives or ovulation-inducing drugs may be prescribed to regulate menstrual cycles and promote ovulation. Assisted reproductive technologies like in vitro fertilization (IVF) may also be considered for women with PCOS who are struggling to conceive naturally. It is essential for women with PCOS who are trying to conceive to work closely with their healthcare providers to develop a personalized treatment plan that addresses their unique needs and maximizes their chances of achieving a successful pregnancy. PCOS QUIZ The common symptoms of polycystic ovary syndrome (PCOS) include: 1. Irregular or absent periods 2. Difficulty getting pregnant due to irregular or absent ovulation 3. Excessive hair growth (hirsutism) on the face, chest, back, or buttocks 4. Weight gain, especially around the abdomen 5. Thinning hair and hair loss from the head 6. Oily skin or acne 7. Male-pattern baldness or thinning hair 8. Infertility 9. Small pieces of excess skin on the neck or armpits (skin tags) 10. Dark or thick skin patches on the back of the neck, in the armpits, and under the breasts[1][2][4][5]. It's important to note that not all individuals with PCOS will experience all of these symptoms, and the severity of symptoms can vary. If you are experiencing these symptoms, it is advisable to consult a healthcare provider for an accurate diagnosis and appropriate management. Do you have any of these symptoms or issues? Irregular menstruation or its absence Abnormal facial and body hair growth Prone to acne Hair loss Infertility Weight increase Skin tags or dark spots Mood-related issues ( depression, anxiety, low self-esteem, poor body image) Sleep apnea  High Blood Pressure Acne on face, chest or neck High triglycerides, low HDL cholesterol  How is PCOS Diagnosed? If you experience symptoms associated with this syndrome, the best thing you can do is see a reproductive endocrinologist. If you don't have an endocrinologist or gynecologist, contact your GP to get a referral. You'll lower the risk of complications as soon as you receive proper medical care and a reproductive endocrinologist diagnoses this health condition. The usual PCOS diagnosis process includes: A clinical examination Evaluation of the medical history Hormonal tests Pelvic ultrasound What are The Main Hormones and Tests that Can Diagnose PCOS? The most conclusive method to diagnose and monitor PCOS is a hormonal analysis, which an endocrinologist usually recommends at different stages of your menstruation. It is paramount to follow your doctor's instructions regarding the timeliness of testing. Here is the most comprehensive PCOS panel that indicates the presence of PCOS while at the same time excluding other diagnoses. Lipid Panel (LDL/HDL,triglycerides) CBC (complete blood count) CMP (comprehensive metabolic count) Prolactin C-Peptide TSH Free T4 Free T3 sex hormone-binding globulin DHEA Sulfate Estrogen FSH Insulin Fasting A1C LH Progesterone 17-OH Progesterone Testosterone, Total (LC/MS), and Free (Equilibrium Dialysis) Vitamin D Buy a PCOS Test Panel Today If you suspect you may have PCOS, it's important to be aware of the symptoms and seek a proper diagnosis from a healthcare provider. PCOS can greatly impact your daily life, from your menstrual cycle and fertility to your overall health. Early detection and management of PCOS are crucial for maintaining a healthy lifestyle. Lifestyle changes, such as regular exercise and a balanced diet, can help manage PCOS symptoms. If you're experiencing symptoms such as irregular periods, acne, or weight gain, get a PCOS test panel and consult a physician trained in this health issue. Remember, knowledge is power when it comes to your health, so don't hesitate to take action and seek the necessary support and guidance. Questions Is there a cure for PCOS? PCOS (Polycystic Ovary Syndrome) is a hormonal disorder that affects many women of reproductive age. While there is currently no cure for PCOS, the symptoms can be managed through lifestyle changes, medications, and other treatments. It's important to work with your healthcare provider to develop a personalized treatment plan that addresses your specific symptoms and concerns. By managing symptoms such as irregular periods, excessive hair growth, acne, and weight gain, you can improve your quality of life and reduce the long-term health risks associated with PCOS. If you have been diagnosed with PCOS or suspect you may have it, consult with your healthcare provider for proper diagnosis and guidance on managing the condition. How can PCOS affect your skin? Polycystic ovary syndrome (PCOS) can affect your skin in various ways due to hormonal imbalances. Some common skin issues associated with PCOS include: 1. Acne: PCOS can lead to increased androgen levels, which can stimulate the sebaceous glands in your skin, leading to acne breakouts. 2. Excessive hair growth (hirsutism): Higher levels of androgens in PCOS can cause increased body and facial hair growth. 3. Skin tags: PCOS is associated with insulin resistance, which may contribute to the development of skin tags. 4. Darkening of the skin (acanthosis nigricans): Insulin resistance in PCOS can result in dark, velvety patches of skin, often seen around the neck, armpits, or groin. Managing PCOS through lifestyle changes, medication, and skincare routines tailored to your specific skin concerns can help alleviate these symptoms and improve the overall health and appearance of your skin. If you are experiencing skin issues related to PCOS, consider consulting a dermatologist for personalized advice and treatment options. Do people with PCOS always develop cysts? No, not everyone with Polycystic Ovary Syndrome (PCOS) develops cysts. The name "polycystic" can be misleading because not all individuals with PCOS have cysts on their ovaries. PCOS is a hormonal disorder that can cause a range of symptoms, including irregular periods, excess androgen levels, and polycystic ovaries. However, the presence of cysts on the ovaries is just one of the criteria used to diagnose PCOS, and some individuals may have the other symptoms of PCOS without having ovarian cysts. It's important for individuals with potential symptoms of PCOS to consult with a healthcare provider for proper evaluation and diagnosis. How common is PCOS, and who is at risk of developing it? PCOS (Polycystic Ovary Syndrome) is a common hormonal disorder among women of reproductive age. It is estimated to affect around 1 in 10 women worldwide. While the exact cause of PCOS is unknown, certain factors may increase the risk of developing it, including: - Family history of PCOS - Insulin resistance - Obesity - Sedentary lifestyle Women with PCOS may experience a range of symptoms, including irregular periods, excessive hair growth, acne, and difficulty conceiving. If you suspect you have PCOS or are experiencing symptoms associated with it, it is important to consult with a healthcare provider for proper diagnosis and management. What treatments are available for PCOS? Treatment options for PCOS (Polycystic Ovary Syndrome) vary depending on the symptoms and individual needs of each person. Some common treatments for PCOS include: 1. Lifestyle changes: This may include regular exercise, a balanced diet, and weight management to help regulate hormone levels and improve symptoms. 2. Birth control pills: Oral contraceptives can help regulate menstrual cycles and reduce symptoms such as acne and excess hair growth. 3. Metformin: This medication is often used to improve insulin sensitivity in women with PCOS, which can help regulate menstrual cycles and improve fertility. 4. Fertility treatments: For women trying to conceive, fertility medications or procedures such as ovulation induction or in vitro fertilization (IVF) may be recommended. 5. Anti-androgen medications: These medications can help reduce symptoms such as acne and excess hair growth by blocking the effects of male hormones (androgens). 6. Surgery: In some cases, surgery, such as ovarian drilling, may be recommended to help restore ovulation in women with PCOS who have not responded to other treatments. It is important for individuals with PCOS to work closely with their healthcare provider to develop a personalized treatment plan that addresses their specific symptoms and goals. Regular monitoring and follow-up care are also essential to managing PCOS effectively. Citations: Symptoms of Polycystic Ovary Syndrome (PCOS) - NHS Polycystic Ovary Syndrome (PCOS): Symptoms and Overview - Johns Hopkins Medicine Polycystic Ovary Syndrome (PCOS): Causes, Symptoms, and Treatment - Cleveland Clinic Symptoms of Polycystic Ovary Syndrome - NICHD PCOS: Symptoms and Causes - Mayo Clinic A Comprehensive Review of PCOS: Pathophysiology and Management - NCBI    

Low T3: Thyroid Hormones and Reverse T3 What is the Thyroid? The thyroid is a small, butterfly-shaped endocrine gland in the lower front of the neck, just below the Adam’s apple. Despite its size, the thyroid has a big job to regulate many bodily functions, including metabolism, growth, and development. This gland produces two main hormones, triiodothyronine (T3) and thyroxine (T4), which are necessary for overall health and well-being. By releasing these hormones into the bloodstream, the thyroid helps your body use energy so every cell can function properly. Thyroid Functions The thyroid is a butterfly-shaped endocrine gland about 2 inches long and is located in the front of your neck below your Adam’s apple. The thyroid has a big job in growth and metabolism by releasing the hormones thyroxine, or T4, and triiodothyronine, or T3, which regulate your body’s ability to convert calories and oxygen into energy. The hypothalamus in your brain produces thyrotropin-releasing hormone, or TRH, which stimulates the release of thyroid-stimulating hormone, or TSH, from your pituitary gland. TSH then travels to your thyroid and tells it to release T4 and T3 into your bloodstream. Under normal conditions, your thyroid produces about 80% T4 and 20% T3 with T3 being 4 times more potent than T4. Keeping T3 and T4 in the normal range is essential for thyroid function and overall health. Every cell in your body has receptors for thyroid hormones that affect your cardiovascular system, bone metabolism, protein synthesis, body temperature regulation, cholesterol production, glucose metabolism, cognitive function, and your gastrointestinal tract. 20 million Americans have some form of thyroid disorder, and women are more affected than men. Thyroid Hormones Thyroid hormones, T3 and T4 are produced by the thyroid gland and are necessary for many bodily functions. T3 is the more active form of thyroid hormone and T4 is converted to T3 in the liver and other tissues. T3 tests are necessary for diagnosing thyroid conditions and understanding T3 levels. These hormones regulate metabolism, heart rate, body temperature and muscle strength. Thyroid hormones are also critical for growth and development especially in children and adolescents for proper physical and cognitive development. What are normal T3 levels? Normal T3 levels are measured in nanograms per deciliter (ng/dL) of blood. The normal range for T3 levels varies among labs but generally is 80-180 ng/dL for adults. For children it’s 100-200 ng/dL. Check your lab report for the reference range, as values can vary slightly among labs. Low T3 Levels: Low T3 levels can mean an underactive thyroid, or hypothyroidism. This is when the thyroid gland doesn’t produce enough thyroid hormones, including T3. Low T3 levels can also be caused by starvation, certain medications, and severe illness. Symptoms of low T3 levels are fatigue, weight gain, dry skin, hair loss, and cold intolerance. In some cases low T3 levels can be a sign of a more serious condition like thyroid cancer or liver disease. High T3 Levels: High T3 levels can mean an overactive thyroid, or hyperthyroidism. This is when the thyroid gland produces too much thyroid hormone, including T3. High T3 levels can also be caused by thyroid nodules, thyroiditis, and certain medications. Symptoms of high T3 levels are weight loss, increased appetite, rapid or irregular heartbeat, fatigue, heat intolerance, and mood changes. In severe cases, high T3 levels can cause a life-threatening condition called thyroid storm. What is Hypothyroidism and Symptoms and T3 Levels? Hypothyroidism is the most common thyroid disorder, characterized by fatigue, weight gain, constipation, hair loss, dry skin, cold intolerance, irregular menstruation, depression, muscle pain, and cognitive impairment. Hypothyroidism is an underactive thyroid gland that doesn’t produce enough hormones for optimal metabolic function. The most common cause of hypothyroidism is Hashimoto’s thyroiditis, which is an autoimmune disorder where the body produces antibodies that attack and destroy thyroid gland tissue. Other causes of hypothyroidism are iodine deficiency, pituitary tumor, radiation therapy on your face, neck, or chest; pregnancy and childbirth; aging; and underconversion of T4 to T3 due to inflammation, stress, selenium deficiency, and overexposure to fluoride, chlorine, or mercury. Liver disease can also affect thyroid function and T3 levels. If you’re experiencing any of the symptoms of hypothyroidism, you should ask your doctor to order blood tests that include TSH, free T4, free T3, reverse T3, and thyroid antibodies if he or she suspects Hashimoto’s. When interpreted correctly, lab results can help determine the underlying cause of your thyroid dysfunction and the right clinical interventions. What is Reverse T3 and T3 Test? Reverse T3 is often excluded by doctors when ordering lab tests for hypothyroidism because they think reverse T3 is an inactive metabolite with no physiological effect on the body. Not addressing reverse T3 has left many patients suffering from hypothyroidism despite their other lab tests coming back within normal range. A T3 test is important in diagnosing thyroid conditions and understanding T3 levels, as it helps to interpret thyroid health comprehensively. But reverse T3 does play a role in metabolic function when your body is under extreme stress by acting as an emergency brake to conserve energy. Under normal conditions, T4 is converted into the more active T3 that binds to cellular receptors all over your body to exert powerful metabolic effects. Reverse T3 is also produced to clear out excess T4 from your body when not needed. But when reverse T3 levels rise too high, it blocks the uptake of active T3 by binding to cell receptors, and the end result is a slowing down of metabolism. According to the National Academy of Hypothyroidism, in a normal thyroid, about 40% of T4 is converted to T3, and 20% is converted to reverse T3 daily. But if your thyroid is malfunctioning or your body needs to conserve energy and is under significant stress, the conversion ratio can change to 50% of T4 becoming reverse T3. A big change like that can impact thyroid function and hormone availability. If you have normal TSH, T4, and T3 but high reverse T3, you will still experience many symptoms of slow metabolism like weight gain, fatigue, depression, constipation, and chronic pain. To determine how T3 and reverse T3 are functioning at a cellular level, you need to calculate your free T3 to reverse T3 ratio by dividing the two numbers from your lab results. For example, if your free T3 is 325 and your reverse T3 is 26, then you just divide 325 by 26, which is 12.5. A healthy T3 to reverse T3 ratio should be above 20. So 12.5 would mean subclinical hypothyroidism. If a doctor prescribes synthetic thyroid medication like levothyroxine to a patient with subclinical hypothyroidism, it can worsen their condition because the T4 in the medication will continue to cause an increase in reverse T3. Thyroid Function Tests Thyroid function tests are important tools in diagnosing and monitoring thyroid disorders like hypothyroidism (underactive thyroid) and hyperthyroidism (overactive thyroid). These tests measure the levels of thyroid hormones in the blood to assess thyroid gland function. The most common thyroid function tests are: Thyroid-stimulating hormone (TSH) test: This test measures the level of TSH, which stimulates the thyroid gland to produce thyroid hormones. Free T3 (FT3) test: This test measures the level of free T3 in the blood. Free T4 (FT4) test: This test measures the level of free T4 in the blood. Thyroid antibody tests: These tests measure the level of antibodies against thyroid cell proteins, which can indicate autoimmune thyroid disorders. Thyroid function testing includes other assessments like radioactive iodine uptake tests to diagnose hyperthyroidism or hypothyroidism. By looking at the results of these tests, healthcare providers can diagnose thyroid conditions and create a treatment plan to get thyroid function back to normal. Non-Blood Tests for Thyroid Function Besides blood tests, there are several non-blood tests that can be used to evaluate thyroid function. These tests are: Radioactive iodine uptake (RAIU) tests: These tests measure the amount of iodine taken up by the thyroid gland. High uptake means hyperthyroidism, and low uptake means hypothyroidism. Thyroid scans: These tests use a small amount of radioactive iodine to create an image of the thyroid gland. This can help identify any abnormalities in the gland, like nodules or cancer. Ultrasound: This test uses high-frequency sound waves to create an image of the thyroid gland. This can help identify any abnormalities in the gland, like nodules or cancer. Thyroid Antibody Tests Thyroid antibody tests are used to diagnose autoimmune thyroid diseases like Hashimoto’s thyroiditis and Graves’ disease. These tests measure the level of antibodies against thyroid cell proteins in the blood. The most common thyroid antibody tests are: Thyroid peroxidase (TPO) antibodies: These antibodies are present in most people with Hashimoto’s thyroiditis. Thyroglobulin (Tg) antibodies: These antibodies are present in some people with Hashimoto’s thyroiditis and Graves’ disease. Thyroid-stimulating immunoglobulin (TSI) antibodies: These antibodies are present in people with Graves’ disease. Thyrotropin receptor antibody (TRAb) tests: These tests detect both stimulating and blocking antibodies in Graves’ disease. Remember, thyroid antibody tests are not used to diagnose all thyroid conditions, and a diagnosis of a thyroid condition can only be made by a healthcare provider based on clinical evaluation, laboratory tests, and medical history. How to decrease reverse T3? There are two steps to decrease high Reverse T3: Remove all the factors that are converting T4 into reverse T3. Flush out the remaining Reverse T3 from your body. Factors that can convert T4 into reverse T3 include chronic illnesses like diabetes, fibromyalgia, arthritis, and Lyme disease; low-calorie diet or eating disorders like anorexia; chronic inflammation like autoimmune diseases; insulin resistance or leptin resistance; extreme exercise like marathons, triathlons, or heavy weightlifting; mental/emotional stress like loss of job, divorce, death of a loved one, or PTSD; gastrointestinal infections or imbalances like intestinal dysbiosis, irritable bowel syndrome, yeast overgrowth, or candida; and certain drugs like beta blockers, antidepressants, and diabetic and antiseizure medications. Radioactive iodine uptake tests can help assess thyroid function and diagnose hyperthyroidism. There are also several nutritional supplements that can support your thyroid gland and convert T4 into T3. One is iodine. Your body needs iodine to make thyroid hormones. In 2007, the World Health Organization estimated that 30% of the world’s population is iodine deficient, and infants born to mothers with hypothyroidism are at risk of learning and developmental delays. The recommended intake of iodine is 1-2 milligrams a day. The second is selenium. The thyroid gland has the highest concentration of selenium by weight of any organ in the body. Selenium is needed to form the enzymes that convert T4 into active T3. As an antioxidant, selenium also protects thyroid tissue from oxidative stress. The recommended intake of selenium is 200-400 micrograms a day. The third is zinc. Optimal zinc helps convert T4 into active T3 and lowers reverse T3. One study showed that when patients with normal T4, low T3 and high reverse T3 were given zinc supplements for 12 months, their T3 levels normalized and reverse T3 went back to normal. The recommended intake of zinc is 30-60 milligrams a day. Once you have addressed your T4 conversion issue, under the guidance of your healthcare provider, you can flush out the excess reverse T3 from your body with bioidentical T3 hormones like Cytomel or compounded and sustained-release T3. T3 cannot be converted into reverse T3 so as you slowly increase your T3 with medication, your T4 and reverse T3 will both go down. T3 medication dose is 5-25 micrograms daily on an empty stomach first thing in the morning. Be patient; it can take 8-12 weeks to feel better as the reverse T3 is flushed out of your system. Side effects can be anxiety, heart palpitations, nausea, and headaches. Work with your doctor to find the right T3 dose for you. GET YOUR THYROID TESTS HERE Thyroid Health Tips Thyroid health is key to overall health. Here’s how to keep your thyroid gland working optimally: Eat well: Include foods high in iodine, like seafood, dairy, and iodized salt, to support hormone production. Exercise: Regular physical activity helps thyroid function and overall health. Manage stress: Stress can harm thyroid function, so manage stress through meditation and yoga. Sleep well: Sleep is key to thyroid function and overall health. Avoid toxins: Some toxins, like pesticides and heavy metals, can affect thyroid function, so minimize exposure. Thyroid health can be affected by many factors, including genetics, age, and certain medical conditions. If you have thyroid concerns, see your healthcare provider, who can do thyroid function tests and give you personalized advice to keep your thyroid healthy. Bibliography  Thyroid Hormones Overview - NCBI Bookshelf What Is Reverse T3? - HealthCentral Research on Reverse T3 - PubMed Overview of the Thyroid Gland - Merck Manuals Understanding Reverse T3 Syndrome - Neuroendocrinology Society Reverse T3 and Its Role in Thyroid Health - Niki Cleuet Blog Thyroid Hormone Production and Function - ColumbiaDoctors Overview of Reverse T3 - Verywell Health Reverse T3 in Clinical Practice - Cleveland Clinic Journal of Medicine Thyroid Hormone: Production, Function, and Regulation - Cleveland Clinic Understanding Reverse T3 and Thyroid Dysfunction - Elixir Naturopathy Reverse T3: Key Insights - Paloma Health The Role of Thyroid Hormones: An Intricate Dance - Revolution Health  

How Long to Fast Before a Testosterone Blood Test: Do You Need To? About 5 million American men suffer from low testosterone levels. This is also known as hypogonadism and can have significant effects on your life. Hypogonadism (testosterone deficiency) is diagnosed by running multiple tests. Patients get one or more testosterone tests to measure their levels. But recent studies found out that your testosterone levels can be affected if the tests were done while fasting. In other words, having a meal before a testosterone test can change the results. Read on to find out more about the correlation between testosterone levels and fasting. How to Test for Low Testosterone? What is the correlation between fasting and testosterone? Study 1 - Testosterone went down significantly after an oral glucose load Study 2 - Eating a meal can lower testosterone levels by a lot Key Takeaway for Future Testosterone Testing Protocols About 5 million American men suffer from low testosterone levels. This is also known as hypogonadism and can have significant effects on your life. Hypogonadism (testosterone deficiency) is diagnosed by running multiple tests. Patients get one or more testosterone tests to measure their levels. But recent studies found out that your testosterone levels can be affected if the tests were done while fasting. In other words, having a meal before a testosterone test can change the results. Read on to find out more. What is a Testosterone Test? A testosterone test is a medical test to measure the level of testosterone in your blood. Testosterone is a hormone produced by the adrenal glands and gonads (ovaries in females and testes in males) that is important for the development and maintenance of male reproductive tissues, bone density and muscle mass. In females, testosterone is present in smaller amounts and helps in the growth and development of bones and muscles. Why is a Testosterone Test Performed? A testosterone test is performed to diagnose and monitor various medical conditions related to abnormal testosterone levels. The test can help identify: Testosterone Deficiency (Hypogonadism): In males, low testosterone levels can cause low sex drive, fatigue, and decreased muscle mass. Testosterone Excess (Hyperandrogenism): In females, high testosterone levels can cause excessive hair growth, acne, and irregular menstrual cycles. Polycystic Ovary Syndrome (PCOS): This common endocrine disorder in females is characterized by high testosterone and androgen excess. Adrenal Gland Disorders: Conditions like Cushing’s syndrome can cause abnormal testosterone production. Monitoring Therapy: It’s also used to monitor testosterone levels in individuals undergoing testosterone replacement therapy or androgen deprivation therapy. Preparing for a Testosterone Test To prepare for a testosterone test: Schedule the Test in the Morning: Testosterone levels are highest in the morning, so schedule your test early in the day. Fasting: Don’t eat or drink anything but water for at least 8 hours before the test. Fasting will give you accurate results. Inform Your Doctor: Tell your doctor about any medications or supplements you are taking, as they may affect testosterone levels. Wear Comfortable Clothes: Wear loose and comfortable clothes and avoid tight sleeves that may make it hard to draw blood. Plan Your Visit: You will be at the testing facility for about 30 minutes, but the blood draw will only take a few minutes. By doing these you can get the most accurate testosterone test results. How to Diagnose Low Testosterone? Testosterone levels are highest in the morning for all healthy males. They start to drop after 11 am and continue to drop towards the end of the day. Testosterone tests are done in the morning because that’s when the levels are highest. If a person sees the classic signs of low testosterone, a test might be required to check this out. These signs are low sex drive, poor concentration, fatigue and even depressive symptoms. But multiple tests are needed to confirm if the person is hypogonadal or not. A testosterone levels test measures the amount of testosterone in a blood sample. For example, your doctor might check your FSH and LH levels. These hormones are produced by the pituitary gland and trigger the testosterone and sperm production in the testicles. Depending on the lab, a healthy male should have a testosterone measurement between 350 ng/dl and 1,250 ng/dL. If below 350 ng/dl and you have low testosterone symptoms, you might be considered hypogonadal. Testosterone levels vary depending on the time of day, diet, age, fitness level and other factors. As mentioned earlier, testosterone tests are done in the morning when testosterone is at its peak. Labs and doctors don’t require patients to fast before a testosterone test. But some studies suggest that fasting before a testosterone test can affect the results. What’s the connection between Fasting and Testosterone Levels? In simple terms, fasting means not eating for a certain period of time, usually 8 to 12 hours. This also includes not drinking anything that makes your organs work to process them, like drinks, milk, etc. Many blood tests require patients to fast before drawing a sample. A standard glucose test is a good example of this. If you eat something and then do a glucose test, you might be labeled as diabetic. That’s because your body didn’t get a chance to process the glucose in your blood, and it will show up in the test. Scientists believe that fasting is also important when testing testosterone through blood tests. In short, eating before your test will temporarily lower your testosterone levels. This can lead to a false diagnosis of hypogonadism if your normal T level is around 400-500 ng/dL. Such findings also mean retesting subjects who were initially diagnosed with low testosterone. Let’s look at a few studies and see the correlation between fasting and testosterone tests in more detail. You’ll see how a glucose load or a full meal can affect the total and bioavailable testosterone levels hours after ingestion. Study 1 - Testosterone Decreased Significantly After an Oral Glucose Load This study was done on 74 men. The average age of the participants was around 50, give or take a few years. The study was done in 2012, and it was a standard 75-g oral glucose tolerance test. An oral glucose tolerance test measures how well your body can process glucose in the blood after you drink a sweet drink they give you at the lab. If you process it fast, your glucose tolerance is good. If it takes too long to process, it’s usually associated with diabetes or other health problems. Almost 60% of the men in the study had normal glucose tolerance. More than 10% were newly diagnosed with diabetes, and about 30% had impaired glucose tolerance. Blood was drawn from each participant at the start of the study and at 30, 60, 90, and 120 minutes, respectively. Other hormones and substances were also measured, such as insulin, leptin, sex hormone-binding globulin (SHBG), and total testosterone levels. None of these individuals had low testosterone at the start of the study. But the results were surprising. The study showed that testosterone levels decreased by 25% after glucose ingestion. That’s a big drop considering most of the participants had normal glucose tolerance. To put it into perspective, if an individual starts with an average testosterone level of 500 ng/dl, a 25% decrease would bring him down to 375 ng/dl. That’s close to the bottom of the normal testosterone range. Interestingly, the testosterone suppression was still present after 120 minutes when blood samples were drawn for the last time. 10 of the participants could qualify for hypogonadism at the end of the study as their testosterone levels went below the baseline. This study shows how important it is to test for testosterone in a fasted state. A simple glucose load can lower total testosterone levels and qualify someone for hypogonadism. Study 2 - Eating a Meal Can Decrease Testosterone Levels Let’s look at another study that shows the correlation between testosterone levels and fed or fasting state. This study shows how a 550-calorie meal of protein, fat and carbohydrates can affect testosterone levels. 11 healthy men participated in this study. They were non-smokers, had no medical treatment, and had normal BMI. The average age was 43 years, and they had no significant medical history. In the first part of the study, the participants were given a 550-calorie meal of buttermilk, cheese, ham, orange juice, and other foods. Blood was drawn at various intervals. The study also measured other hormones such as LH, SHBG, and glucose. Free testosterone, the unbound fraction and biologically active, was also measured. The participants finished the meal in about 15 minutes. The foods were varied, as the study designers wanted to mimic a meal that most men would eat on a daily basis. Before the meal, the participants were told to fast for 12 hours. They were also instructed not to have sex or do any strenuous exercise that would affect their testosterone levels. The same procedure was repeated a few weeks later with the same participants. This time they only fasted for 12 hours and didn’t eat after. Blood was drawn in the fasting state, and all other parameters were the same. When the two experiments were compared, the results were striking. In both groups, the initial fasting testosterone levels were the same. LH and SHBG were unchanged. But in the fed group, testosterone levels decreased 15 minutes after meal ingestion. And 30 minutes after the meal. Other hormones and parameters were the same; just total and bioavailable testosterone levels went down. Upon reviewing the results, the experts found out that the decrease in testosterone was 30%. This was true for all participants with no exceptions. This study shows how testing for testosterone in a fasted state is different from testing in a fed state. Takeaway for Future Testosterone Testing Protocols The scientific literature on sexual medicine says that food intake can affect testosterone levels. But the standard testosterone test protocol doesn’t require fasting before the test. The studies above open up a potentially big change in how testosterone tests are done. Also, there was no significant difference in LH, SHBG, and other hormones among the participants. This means the hypothalamic-pituitary-testicular (HPT) axis was not really affected by food or glucose intake, but testosterone production was. It’s believed that insulin, a hormone produced by the pancreas when we eat to process glucose, can temporarily decrease testosterone production at the testicular level. If you think you have low testosterone, order these testosterone tests online at an affordable price and see how your hormones are doing.   References : Testosterone decrease after a mixed meal in healthy men independent of SHBG and gonadotropin levels. Andrologia. Volume 44, Issue 6 December 2012. Pages 405-410. Abrupt decrease in serum testosterone levels after an oral glucose load in men: implications for screening for hypogonadism. Clin Endocrinol (Oxf) 2013 Feb;78(2):291-6. Testosterone Test - Testing.com Testosterone as a Fasting Blood Test? - Grand Rounds in Urology Testosterone blood test – how to prepare for your blood test | healthdirect Is a fasting testosterone level really necessary for the determination of androgen status in men? - PubMed

TRT Side Effects: How to Manage Them What are the Main Side Effects of Testosterone Replacement Therapy (TRT)? Acne/oily skin  Hair loss Increased sex drive Unresolved erectile dysfunction Insomnia Sleep Apnea Testicular atrophy Enhanced assertiveness or reactivity High blood pressure/water retention Gynecomastia (male breast development)   Understanding Testosterone Replacement Therapy (TRT) Testosterone replacement therapy (TRT) is a medical treatment designed to restore normal testosterone levels in men with hypogonadism, a condition where the testicles do not produce enough testosterone. This therapy aims to alleviate symptoms such as low libido, fatigue, and decreased muscle mass, which are commonly associated with low testosterone levels. TRT involves administering testosterone through various methods, including injections, gels, patches, and oral medications. By restoring testosterone levels, TRT helps improve overall quality of life for men suffering from androgen deficiency syndromes. What are the Main Side Effects of Testosterone Replacement Therapy (TRT)? Like all treatments, testosterone therapy is associated with a number of known risks, particularly for men with testosterone deficiency. These risks should be communicated to patients prior to initiation of treatment. A key item is impaired spermatogenesis (sperm production) due to suppression of gonadotropins (LH and FSH). Men considered candidates for TRT should be questioned as to their desire to induce a pregnancy. Since sperm production may be reduced to zero, exogenous T alone should be avoided until fertility is no longer a concern. Treatment with hCG injections or oral clomiphene citrate may be considered in these men, as they do not suppress spermatogenesis. There is some limited data on the use of testosterone plus hCG for improvement of sperm quality and quantity in men. Acne may occur in younger men. Edema can be occasionally observed in middle-aged or older men due to the fluid-retentive properties of testosterone. Erythrocytosis (increased red blood cell count that causes high hematocrit) is infrequently seen with topical and injectable TRT treatments but is routinely observed in men treated parenterally with short-acting injections or implanted pellets. Although there is no evidence to date that T-induced erythrocytosis is associated with adverse events, it seems reasonable to prevent the hematocrit from rising excessively. Men whose hematocrit rises above 54% (or hemoglobin greater than 18 g/dL) should be considered for dose reduction, temporary discontinuation of T therapy, blood donation, or therapeutic phlebotomy. Read this first since it is the most common testosterone side effect: High hematocrit Acne/oily skin  Caused by Dihydrotestosterone (DHT) effect on increased oil production · Accutane– a powerful prescription item - 40 mg/day for one week sometimes stops acne if started at the first sign or as directed by your doctor. Accutane is potentially highly liver toxic and can lower testosterone. Do not use unless as last resort.· Sporanox—Effective for some acne-like eruptions that are caused by fungi. Some doctors also prescribe antibiotics, like tetracycline, for acne with good results.. Minocycline. Shower with Nizoral shampoo. Anti-bacterial soaps: use a scrubbing brush and wash twice a day, especially after sweating during a workout.· UV light or sunlight with moderation.. Zinc/copper supplements or zinc soaps may help some men with acne.. Other options: How to treat and prevent acne Hair loss Caused by DHT effect on hair follicles · Nizoral shampoo—Available by prescription and over-the-counter as a lower-dose product.· Rogaine—Available over the counter· Propecia - Available by prescription. A few males experience decreased erections with finasteride. Do not use. Increased sex drive · A problem? Sex drive is part of quality of life. Testosterone therapy may somewhat improve sexual function in men with low testosterone levels. This is not necessarily a bad side effect. Enjoy it. Unresolved erectile dysfunction · ED Medications: Available by prescription; enables robust erections. If you have sinus congestion or headaches/backaches, take non-drowsy allergy medication and ibuprofen. ED drugs can be combined with alpha-blockers and/or nitric oxide precursor amino acids (arginine or citrulline).· Yohimbine (Yocon) - Available by prescription; increases sex organ sensitivity. Can increase heart rate and blood pressure· Muse—Available by prescription; a pellet is inserted into the urethra to produce an erection. Unpopular· Trimix – Available by prescription from compounding pharmacies. The best and cheapest formula for injection into the penis for lasting erections.· Caverject - Available by prescription. An injection into the penis that produces an erection that can last 1 to 2 hours. Be careful with injecting too much since it can produce dangerously long erections that need to be treated in emergency rooms! Follow instructions from your urologist.· Papaverine—an older injectable medication, less expensive than Caverject.· Wellbutrin—prescription at 300 to 450 mg/day; increases dopamine.· HCG—First dose is 2,000 IU, then 250-500 IU twice or three times a week. No protocol has been proven in controlled studies yet. When Testosterone Replacement Doesn't Lead to Better Erections Insomnia Usually, this is caused by dosages that are too high. Find the least amount that gives you a good result. · Sleeping medications—e.g., Ambien, Sonata, Lunesta, Restoril· Melatonin: 1 to 3 mg before bedtime. If you wake up groggy after 6 hours, your dose should be lower.· Avoid working out too close to bedtime.· Limit caffeine, especially after 3 pm.· You may want to try a sleep formula with tryptophan, melatonin, and magnesium. Nutrients do not work as well as drugs, but they can help some people.Article: How to protect your circadian rhythm Unresolved Fatigue · Have your doctor prescribe a sleep study if you snore and wake up tired even after 7 hours of sleep. Some people may have to wear a C-PAP machine to breathe at night. Visit Home - SleepApnea.org for more information. There are also oral devices for those people who fail CPAP. Fatigue—When Testosterone Is Not Enough Testicular atrophy · HCG– One 2,000-unit injection per week for 2 weeks, followed by maintenance of 350-500 IU twice a week. Decrease testosterone dosage accordingly after starting hCG to reach levels around 500-1200 ng/dL while keeping all other lab work monitored. Watch this video on hCG and men Enhanced assertiveness or reactivity · Make sure you are getting enough sleep.. Count until 10 and be aware of your interaction with others.· Decrease caffeine.· Meditation, mindfulness, yoga; breathe from your belly for a few minutes when overreacting.· The testosterone dosage may be too high.· Ask yourself: Do I need to always be right?. Vent extra energy at the gym, sex, and sharing with your buddies at www.excelmale.com High blood pressure/water retention · Caused by sodium retention in the kidneys. Try to limit salt consumption. Caution is required due to potential water retention issues in patients with chronic kidney disease. . Blood pressure medications - Elevated blood pressure may be transient or not. Try ACE or ARBs since they seem to have fewer sexual dysfunction-related effects. · Magnesium (600 mg/day); vitamin B6 (100 to 200 mg/day); may help reduce water retention. · Water - Drink extra water every day to help flush the kidneys. . Check your estradiol to make sure it is not over 45 pg/ml. Treat if high with a low dose of anastrozole. . Make sure you are doing cardio exercise at least 3 times a week for 30 min. Sweat and lower your salt intake since TRT increases sodium retention in some men. Gynecomastia (male breast development) Caused by high estradiol in the presence of low testosterone. This is rare in men on testosterone replacement. · Arimidex inhibits estrogen production. Available by prescription. 0.25 mg per week. There is no agreement on what the highest E2 level is for men on TRT with high testosterone. Ensure that your estradiol does not go too low (under 20 pg/ml) if you use anastrozole since it is needed for bone, skin, brain, lipids, libido, good lipids and hair health.· Nolvadex (tamoxifen)– Competes with estrogen for receptors. Available by prescription, 10 to 20 mg/day. Use of Nolvadex during a steroid cycle may reduce the net anabolic effect, as it decreases the production of GH and IGF-1. High IGF-1 may be implicated in gynecomastia.. Severe cases may require removal of the breast tissue by surgery.· DHT cream- Some people have obtained great results by rubbing a 10% DHT cream on their nipples. Not available in the US but some people order it online from Germany. Read about medications/foods to avoid if you have gynecomastia.. Those who do know to respond to the above check other reasons. Find out how long it takes testosterone replacement to potentially show benefits For affordable blood tests in most cities in the U.S. : DiscountedLabs.com More information on TRT lab tests. Monitoring and Testing During TRT Regular monitoring and testing are essential during TRT to ensure safe and effective treatment. This includes: Regular blood tests to check testosterone levels, PSA, hematocrit, and liver enzymes Baseline bone density testing (DEXA) and bi-yearly bone density tests Monitoring of prostate health through PSA levels and DREs Regular check-ups with a healthcare provider to discuss any concerns or side effects These tests help in tracking the effectiveness of the therapy and in identifying any potential issues early, ensuring that the treatment remains beneficial and safe. When to Seek Care It is essential to seek medical attention immediately if any of the following occur during TRT: Symptoms of a cardiovascular event, such as chest pain or shortness of breath Severe side effects, such as acne, hair loss, or mood changes Changes in prostate health, such as increased PSA levels or abnormal DRE results Concerns about testosterone levels or overall health By understanding the benefits and risks of TRT, monitoring prostate health, and seeking care when necessary, men with hypogonadism can safely and effectively manage their condition and improve their overall quality of life. Regular communication with healthcare providers and adherence to recommended monitoring protocols are key to successful testosterone replacement therapy. References: [i]   Metzger, DL, et al. Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for a stimulatory role of endogenous estrogens during male adolescence. J Clin Endocrinol Metab (1994) 79(2):513-518. [ii] el-Sheikh, MM, et al. The effect of Permixon (saw palmetto) on androgen receptors. J Acta Obstet Gynecol Scand (1988) 67(5):397-399. [iii] Suzuki, K, et al. Endocrine environment of benign prostatic hyperplasia: prostate size and volume are correlated with serum estrogen concentration. Scand J Urol Nephrol (1995) 29:65-68. [iv] Gann, PH, et al. A prospective study of plasma hormone levels, nonhormonal factors, and development of benign prostatic hyperplasia. The Prostate (1995) 26:40-49.   Buy your own on DiscountedLabs.com

A chloride blood test, which is also called a serum chloride test, is often part of a routine blood test to check how much chloride is in your blood. Chloride is an important electrolyte. It helps keep the balance of fluids and acids in your body. Chloride Blood Test: What You Need to Know Many people do not think about electrolyte balance when looking at someone’s overall health. Electrolytes like sodium, potassium, chloride, and calcium are very important, and an electrolyte imbalance can lead to various health issues. They help manage several functions in the body. This includes pH balance and fluid regulation, among other things. Chloride is an important electrolyte in your body. Your kidneys manage it. When you have the right amount, chloride is good for your health. However, if there is too much or too little, it can lead to several issues. Keep reading to learn more. What Is Chloride? Chloride is an important electrolyte that keeps the acid-base balance in your body. This balance is called pH, and it prevents your blood from being too acidic or too alkaline. Chloride also plays a role in sending nerve signals. These signals control the many muscles in your body. Chloride is commonly ingested through sodium chloride, which is table salt, and plays a crucial role in maintaining electrolyte balance. Normal chloride levels in adults range from 98 to 107 mEq/L in the blood. Having chloride levels above that can cause symptoms and health problems. Why Do I Need a Chloride Blood Test? A chloride blood test is typically ordered by your healthcare provider as part of a routine blood screening to check your general health. This test is crucial for monitoring and diagnosing conditions related to an imbalance of acids or fluids in your body. If you experience symptoms such as nausea, vomiting, diarrhea, constipation, muscle weakness, fatigue, confusion, or disorientation, your healthcare provider may order a chloride blood test to determine the underlying cause. Additionally, if you have a medical condition like kidney disease, heart failure, or liver disease, your healthcare provider may use this test to monitor your condition and adjust your treatment plan as needed. Monitoring your chloride levels can aid in the effective management of these conditions and help prevent any potential complications. What Are the Symptoms of High Chloride Levels? This condition, known as hyperchloremia, occurs when there are high blood chloride levels. It happens when there is too much chloride in the blood. This can cause different symptoms, including: A lot of muscle weakness and tiredness Feeling thirsty most of the time High blood pressure Confusion and low energy Hyperchloremia usually makes you feel tired and not interested in doing things. But these symptoms often happen with other health issues too. The best way to check if your chloride levels are high is through a blood test. Some people may not feel any symptoms at all. If they do feel symptoms, these can be different for each person. Factors such as age, sex, fitness level, and others can affect how symptoms show up. What Are the Causes of Hyperchloremia? Your kidneys help control the level of chloride in your body. They keep a fine balance with your electrolytes. Problems with your kidneys can make it hard to manage chloride properly. This often leads to having too much chloride in your system. Acute kidney injury can also lead to elevated chloride levels, as the kidneys are unable to properly filter and balance electrolytes. Here are other potential causes: Frequent diarrhea. Eating too much salt, saltwater, or saline in a hospital. Renal acidosis: This occurs when your kidneys cannot remove acid well, leading to too much acid in your blood. Using drugs like carbonic anhydrase inhibitors—these treat glaucoma but may lower bases in your body. Respiratory alkalosis: this usually happens when someone breathes fast and has low carbon dioxide in their blood. In some situations, a person may experience hyperchloremic acidosis. This happens when the body loses something that is alkaline or keeps too much that is acidic. Issues like severe diarrhea, certain medicines, or kidney damage can lead to this condition. What Do High Chloride Levels Mean? The best way to find out if there is too much chloride in your blood is through a blood test. You can request a specific test just for this electrolyte. This test is often known as a chloride blood test. It is a good idea to test other electrolytes and related substances in your body. This can help you understand more about your pH balance. It also gives insights into your kidney function. Plus, you can learn how your body processes electrolytes like chloride. You can order a Comprehensive Metabolic Panel. This set of blood tests checks several levels in your body. It looks at sodium, potassium, calcium, chloride, and carbon dioxide. It may also check for other things like albumin, bilirubin, and blood urea nitrogen. This helps doctors check for other health issues. It also helps them find out why you have too much chloride in your blood. This test is crucial for monitoring and diagnosing conditions related to an acid or fluid imbalance in your body. The results from this blood test usually come back in a few business days. You can expect to have an accurate answer in about a week. What Are the Complications of High Chloride Blood Test Levels? A set of kidneys that do not work well can lead to high blood chloride levels. This problem could cause issues related to these important organs. It is important to act quickly and get a comprehensive metabolic blood test. For example, some problems caused by hyperchloremia are: Kidney stones Complete kidney failure Poorly working kidneys that may need a transplant in the future Heart and muscle issues Bone problems and diseases If you have too much chloride in your body, your blood can become very acidic. When the blood is too acidic, it flows through your heart and muscles. Over time, this can cause damage. This is how problems with these organs can happen. Too much chloride can cause problems with calcium levels. Over time, this might lead to bone diseases or other health issues if your body can’t handle calcium well. Calcium is very important for keeping your bones healthy. How Is High Chloride Treated? Having too much chlorine in the blood is treated with the right care. The treatment for hyperchloremia depends on what is causing the electrolyte imbalance and other factors. For example, if you have high chloride due to dehydration, make sure to drink a lot of water. Your doctor might tell you to stop drinking caffeine and alcohol. These drinks can make your body lose more fluids. This could make your dehydration problem worse. Another way to help is by stopping the drugs that increase chlorides in your blood. If your kidneys do not work well, a nephrologist could offer the right treatment for you. Dietary Recommendations for Chloride Levels Maintaining a healthy diet is essential to keep your chloride levels in check. Here are some dietary recommendations to help you manage your chloride levels: Stay Hydrated: Drinking plenty of water is crucial for maintaining a healthy balance of fluids and electrolytes, including chloride. Proper hydration supports overall bodily functions and helps prevent electrolyte imbalances. Limit Sodium Intake: Consuming high amounts of sodium can lead to an imbalance of chloride in your body. To avoid this, limit your sodium intake by steering clear of processed and packaged foods, and opting for fresh fruits and vegetables instead. Eat Chloride-Rich Foods: Incorporate foods rich in chloride into your diet, such as celery, olives, and seaweed. These foods can help maintain your chloride levels within the normal range. Avoid Excessive Salt Intake: Excessive salt intake can disrupt the balance of chloride in your body. Be mindful of your salt consumption by avoiding overly salty foods and choosing healthier, low-sodium alternatives. By following these dietary tips, you can help ensure your chloride levels remain balanced, supporting your overall health. When to Seek Medical Attention If you experience any of the following symptoms, seek medical attention immediately: Severe Vomiting or Diarrhea: These symptoms can lead to dehydration, which may cause an imbalance of chloride in your body. Prompt medical attention is necessary to address the underlying issue and restore balance. Muscle Weakness or Fatigue: Persistent muscle weakness or fatigue could indicate an underlying medical condition that needs to be addressed. It’s important to consult with a healthcare provider to determine the cause and receive appropriate treatment. Confusion or Disorientation: Experiencing confusion or disorientation can be a sign of a serious health issue. Seek medical attention to identify the cause and receive the necessary care. Severe Abdominal Pain: Severe abdominal pain may signal an underlying medical condition that requires immediate attention. Don’t ignore this symptom; consult with a healthcare provider for proper evaluation and treatment. If you have any concerns about your chloride levels or experience any of the above symptoms, consult with your healthcare provider for proper evaluation and treatment. Monitoring and managing your chloride levels is essential for maintaining your overall health and well-being. Treatment Options The treatment for hyperchloremia depends on what is causing it. Hydration: If someone has high chloride levels due to not drinking enough, drinking more water or getting fluids through an IV can help. Medication Adjustment: A healthcare provider may change or stop medications that are raising chloride levels. Dietary Changes: Consuming high amounts of sodium chloride can lead to an imbalance of chloride in your body. Eating less salt can help keep chloride levels in check. Addressing Kidney Issues: If high chloride levels are related to kidneys, treating the kidney problem is important. In serious cases, dialysis might be needed. Treating Metabolic Acidosis: Giving sodium bicarbonate can help balance excess acid in the blood. Stopping Excessive Saline: If high chloride levels are caused by too much saline intake, it’s important to stop or cut back on it. Prevention and Management Preventive measures include: Drink enough water. Cut down on salt. Keep track of and change medications that impact electrolyte imbalance. Have regular doctor visits to find and treat any hidden health issues. Order the Comprehensive Metabolic Panel Today! Many people may not feel any symptoms of having too much chloride in their bodies. However, they could still have this health problem. The best way to check if chloride is making you feel tired or confused is by getting a routine blood test, such as a comprehensive metabolic panel. You can order this test today. It helps monitor health issues like high blood pressure, heart failure, kidney disease, and liver disease, which can cause an imbalance in electrolytes. If you feel very tired or have weak muscles, this might mean there is a fluid imbalance from high chloride levels or too much base. This can lead to metabolic alkalosis. Overusing antacids can also play a role in this. You can get the complete metabolic CMP panel blood test from Discountedlabs.com today! This company offers you the lowest prices on blood tests. You will receive your results by email in a few business days. Frequently Asked Questions Should I be concerned if I have a low or high chloride blood test result? It is important to talk to a healthcare professional if you have worries about your chloride blood test results. A low or high chloride level can show an electrolyte imbalance or an underlying cause of a health issue. For example, renal tubular acidosis happens when your kidneys do not remove enough acids from your blood into your urine. Low chloride levels can have several other possible causes. These include temporary issues like vomiting and dehydration. High serum creatinine levels can point to metabolic acidosis, which is a more serious cause. It is necessary to remember that the amount of fluid you drink before the test can change the results. So, ask your doctor if you need to adjust your fluid intake. A healthcare professional can accurately read your test results and help you with the next steps or treatments related to table salt. What treatments are prescribed to affect chloride levels? I’m sorry, but I cannot give medical advice or details about treatments for chloride levels. For instance, treatments may vary if the high chloride levels are due to acute kidney injury. It is best to talk to a healthcare professional. They can offer personalized guidance based on your needs and situation. What is a chloride blood test, and why is it done? A chloride blood test, or “Cl test,” is often part of a routine blood test to measure the level of chloride in your blood. Chloride is an electrolyte that helps keep the balance of fluids in your body. This test is often part of a comprehensive metabolic panel or an electrolyte panel. It helps check your overall health and can assist in finding issues like dehydration, kidney disease, respiratory alkalosis, acidosis, or certain metabolic disorders. The results from the chloride blood test, together with other electrolyte test results, give important information to your healthcare provider about your electrolyte balance and health. Abnormal levels of chloride can happen due to several factors, like dehydration, vomiting, or other medical conditions. It’s important to talk to a healthcare professional about your results. The level of chloride in your blood can really affect your health. A basic metabolic panel is a common test that also measures chloride and other essential electrolytes to check how your body is working. What are the normal levels of chloride in the blood? The normal levels of chloride in the blood usually range from 96 to 106 milliequivalents per liter (mEq/L). This range is considered typical. However, different laboratories may have slightly different reference ranges. If you are worried about your chloride levels, it’s a good idea to talk to a healthcare professional. A low chloride level means you do not have enough chloride in your blood, which is known as hypochloremia. Doctors often find this condition through a chloride blood test, which can indicate high blood chloride levels. This test is part of a normal blood screening to check or diagnose electrolyte levels. How should I prepare for a chloride blood test? To get ready for a routine blood test, including a chloride blood test, follow some simple steps. This will help you get the right results. Here is what you can do: Follow any fasting instructions. Sometimes, your healthcare provider may ask you to fast for a while before the test. This means you should not eat or drink anything, except for water, for a set period. It is important to carefully follow these instructions. Tell your healthcare provider about any medications or supplements you are using. Some medications and supplements can change the chloride levels in your blood. It’s important to share this information so your healthcare provider can consider it when looking at your test results. Stay hydrated: Drinking enough water before the test can help give accurate results. However, do not drink too much water just before the test. This can make the blood sample less clear. Talk to your healthcare provider about any worries you have. If you have questions about the chloride blood test, feel free to ask your healthcare provider. They can give you more information and help you with any concerns. Remember, these are general rules. Your healthcare provider may give you special instructions based on your situation. It is always a good idea to follow their advice to get the best results. Is there anything specific I need to do after the test, such as follow-up appointments or lifestyle changes? It really depends on the test you took and the results you got. Usually, it’s helpful to speak with your health care provider about your test results, especially if they indicate an electrolyte imbalance. They can suggest what to do next, like getting a urine test. Your health care provider will help you with any visits, more tests, or changes in your life that you might need based on the results. It is very important to talk to your health care provider and follow their advice for your situation. Sources: [1 ] Hyperchloremia [2] What to know about high chloride levels in blood [3] Causes and symptoms of hyperchloremia