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When it comes to TRT blood pressure, understanding the various factors that can impact this crucial health metric is essential for men who use testosterone. In this blog post, we'll talk about the link between testosterone replacement therapy (TRT) and high blood pressure, as well as some of the possible side effects and problems that may come up during treatment. We'll talk about the dangers of TRT-induced high blood pressure and emphasize how crucial regular monitoring is. Additionally, we'll examine water retention and edema in men on TRT, shedding light on their causes and management strategies. Furthermore, our investigation into testosterone's impact on kidney functioning will provide valuable insights into how hormone therapy affects renal function. We'll also debunk common misconceptions surrounding estrogen conversion's role in extracellular water (ECW) increases while exploring alternative explanations for changes in fluid balance during TRT. Lastly, we'll address lifestyle factors influencing water retention during hormone therapy, such as sodium intake, alcohol consumption's effects on fluid balance, and the significance of regular exercise throughout treatment. By gaining a deeper understanding of these issues related to TRT, blood pressure management becomes an achievable goal for those undergoing hormone therapy. Table of Contents: High Blood Pressure and TRT Risks Associated with High Blood Pressure Caused by TRT Importance of Regular Blood Pressure Monitoring Water Retention and Edema in Men on TRT Causes Behind Edema-Related Swelling in Men on TRT Strategies for Managing Water Retention The Importance of Cardiovascular Workup Testosterone's Impact on Kidney Functioning The Role Played by Kidneys in Regulating Body Fluids How Testosterone Affects Renal Function Taking Control of Blood Pressure During TRT Estrogen Conversion Not Responsible for ECW Increase Debunking Misconceptions about Estrogen's Role in ECW Increase Investigating Alternative Explanations for Changes in Fluid Balance Moving Forward: The Importance of Ongoing Research Lifestyle Factors Influencing Water Retention During TRT The Role of Sodium Intake in Water Retention Effects of Alcohol Consumption on Fluid Balance Importance of Regular Exercise During Hormone Therapy FAQs in Relation to Trt Blood Pressure Does TRT therapy raise blood pressure? Does testosterone play a role in blood pressure? Can testosterone cypionate cause high blood pressure? Does low testosterone shots cause high blood pressure? Conclusion High Blood Pressure and TRT Several studies have determined that having low testosterone may increase the incidence of high blood pressure in men. TRT can improve blood pressure control in hypogonadal men. However, in some other men, testosterone replacement therapy (TRT) can increase blood pressure during the initial weeks of treatment. Monitoring your blood pressure is crucial to regaining control over it while on TRT. In this section, we will discuss the dangers of TRT-related high blood pressure and emphasize the significance of regular blood pressure monitoring. Risks Associated with High Blood Pressure Heart Attacks: Elevated blood pressure puts extra strain on your heart muscles, which may eventually lead to heart attacks. When arteries become narrow due to plaque buildup or a clot forms in one of these vessels supplying oxygen-rich blood to your heart muscle cells, it could cause permanent damage. Strokes: High blood pressure can also cause strokes, which occur when there's an interruption in the flow of oxygenated blood supply towards specific regions within our brains, leading them to not be able to function properly anymore, resulting in either death, tissue loss, or, depending upon severity, the location of the affected area(s). Kidney Damage: Prolonged hypertension may result in chronic kidney disease (CKD) due to the increased workload placed on these organs, which filter waste products out of the bloodstream efficiently enough for elimination via the urine production process, eventually leading to renal failure if left untreated over time. Erectile Dysfunction: High blood pressure can cause erectile dysfunction by damaging the lining of your blood vessels and limiting the flow of blood to your penis. This makes it difficult for men to achieve or maintain an erection during sexual activity. Brain Shrinkage: Studies have shown that high blood pressure may contribute to a reduction in brain volume, also known as brain shrinkage. This condition has been linked with cognitive decline and an increased risk of dementia later in life. Importance of Regular Blood Pressure Monitoring To mitigate these risks while undergoing TRT, it is essential to monitor your blood pressure regularly if it is increasing. Here are some reasons why regular monitoring is crucial: Detecting Early Warning Signs: Frequent measurements help identify any fluctuations in your BP levels before they escalate into more severe health issues such as heart attacks or strokes, allowing you to take preventive measures early on. Maintaining an Optimal Treatment Plan: By keeping track of how well current medications work in controlling hypertension symptoms (if applicable), doctors are able to adjust dosages accordingly to ensure the best possible outcome for patients' overall wellbeing throughout the duration of therapy sessions undertaken using testosterone replacement products/services available in today's medical industry standards, practices, guidelines, and recommendations set forth by medical groups. Lifestyle Adjustments: Tracking changes allows individuals to pinpoint specific factors contributing to their elevated pressure - whether it be dietary habits, stress levels, or lack of exercise regimen adherence, among others; thus enabling them to make necessary adjustments in order to improve their overall health status while still receiving the benefits associated with TRT treatments being administered under the supervision of healthcare professional team members involved in the case management process. In conclusion, understanding the risks of high blood pressure caused by testosterone replacement therapy and monitoring your BP regularly is essential for maintaining optimal health during treatment. By making lifestyle adjustments and working closely with your healthcare provider, you can effectively manage hypertension while reaping the benefits of TRT.   Key Takeaway:  In some men with metabolic syndrome, older age, and other factors, testosterone replacement therapy (TRT) can increase blood pressure, which poses long term risks such as heart attacks, strokes, kidney damage, erectile dysfunction, and brain shrinkage. Monitoring and treating your blood pressure is crucial to regain control over it while on TRT, and making lifestyle adjustments with the help of healthcare providers can effectively manage hypertension while reaping the benefits of TRT. Water Retention and Edema in Men on TRT One potential side effect of testosterone therapy is edema, particularly dependent edema, which is more common in older men [10]. Edema refers to water retention, and dependent indicates water retention towards the ground, such as when sock imprints are visible around the ankles after removing them. Testosterone-induced water retention can cause swelling in the extremities, particularly in the legs and feet, leading to discomfort and potential complications if left untreated. A study looking at various doses of testosterone enanthate in older men revealed nearly half experienced leg edema in the groups provided with supraphysiologic testosterone (300 and 600 milligrams per week of testosterone enanthate). A comprehensive cardiovascular workup may help identify any underlying issues contributing to this condition, while maintaining a low-sodium diet and drinking plenty of water can alleviate symptoms. In this section, we will discuss the causes behind edema-related swelling in men on TRT and strategies for managing water retention. Causes Behind Edema-Related Swelling in Men on TRT The primary cause of edema-related swelling during TRT is an increase in extracellular fluid volume resulting from testosterone's impact on sodium reabsorption in the kidneys. Testosterone stimulates sodium and water retention through an autocrine or paracrine mechanism that affects sodium metabolism, leading to elevated blood pressure levels experienced by some men undergoing hormone therapy. Men with pre-existing metabolic syndrome, obesity, baseline high blood pressure, and kidney dysfunction can be more susceptible than others to having this problem. Additionally, certain lifestyle factors, such as high sodium intake, alcohol consumption, and a lack of exercise, can exacerbate these symptoms. Strategies for Managing Water Retention To minimize the impact of TRT-induced edema and improve overall health outcomes, it is essential to adopt effective management strategies targeting both hormonal imbalances caused by treatment itself as well as lifestyle factors that contribute to fluid accumulation within the body: Maintain a Low-Sodium Diet: Reducing your daily salt intake helps prevent excessive fluid buildup around cells, which could lead to hypertension. Aim for less than 2300 mg per day, according to CDC guidelines. Stay Hydrated: Drinking adequate amounts of water helps flush out excess sodium and promotes healthy kidney function. Aim for at least eight 8-ounce glasses per day, or consult your healthcare provider for personalized recommendations based on individual needs. Incorporate Regular Exercise: Engaging in regular physical activity not only aids weight management but also improves circulation and reduces fluid retention. Choose activities that you enjoy, such as walking, swimming, or cycling, to maintain consistency. Minimize Alcohol Consumption: Alcohol can dehydrate the body and increase water retention by disrupting hormonal balance. Limiting alcohol intake will help minimize edema-related swelling during TRT. Monitor Blood Pressure Regularly: Keeping track of your blood pressure levels is crucial to ensuring they remain within a healthy range while undergoing hormone therapy. Invest in a reliable home blood pressure monitor and take readings daily until control is regained. Besides these strategies, it's essential to communicate with your healthcare provider about any concerns related to edema or other side effects experienced during TRT. They may recommend adjustments in dosage or additional medications such as diuretics (water pills), which aid in reducing fluid buildup within the body, if necessary. Physicians may also recommend lowering the TRT dose or switching from testosterone injections to gels to attain lower testosterone blood level peaks. The Importance of Cardiovascular Workup If you are experiencing persistent edema-related swelling despite implementing the above strategies, it might be time for a comprehensive cardiovascular workup conducted by a qualified medical professional specializing in men's health issues like testosterone deficiency (hypogonadism). A qualified medical professional specializing in men's health issues such as testosterone deficiency (hypogonadism) can perform a comprehensive cardiovascular workup to assess any underlying heart or vascular issues that may be contributing to fluid retention. In conclusion, managing water retention during TRT is crucial for maintaining optimal health outcomes while undergoing hormone therapy. By adopting effective strategies targeting both hormonal imbalances caused by treatment itself as well as lifestyle factors that contribute to fluid accumulation within the body, men on TRT can minimize edema-related swelling and improve their overall quality of life.   Key Takeaway:  Due to the effect of testosterone on kidney function, men receiving testosterone replacement therapy (TRT) may experience swelling associated with edema. To manage this side effect, men should maintain a low-sodium diet, stay hydrated, exercise regularly, minimize alcohol consumption, and monitor their blood pressure levels. If these strategies do not work, it is important to seek a comprehensive cardiovascular workup from a qualified medical professional specializing in men's health issues like hypogonadism. Testosterone's Impact on Kidney Functioning Increased extracellular water retention, which is a result of testosterone's impact on kidney function, may be the cause of elevated blood pressure levels in men undergoing TRT. One possible explanation for this phenomenon is the direct impact of testosterone on the way kidneys manage sodium in the body. In this section, we will explore the role played by kidneys in regulating body fluids and how testosterone affects renal function. The Role Played by Kidneys in Regulating Body Fluids Kidneys play a crucial role in maintaining overall health by filtering waste products from the bloodstream and excreting them as urine. Additionally, these vital organs are responsible for balancing electrolytes such as sodium and potassium while also controlling fluid balance within the body. This process involves adjusting both water intake through thirst signals and water output via urine production based on factors like hydration status, blood pressure levels, and hormone regulation. A key component of kidney function is its ability to regulate extracellular fluid volume (ECFV), which includes both interstitial fluid surrounding cells and plasma within blood vessels. ECFV directly impacts blood pressure since it determines the amount of circulating blood volume that needs to be pumped throughout the body by the heart. How Testosterone Affects Renal Function The primary effect of testosterone on the kidneys is the stimulation of sodium reabsorption. This means that the kidney cells are instructed to retain more sodium, which can lead to an increase in blood pressure. This is one of the reasons why testosterone replacement therapy is not recommended for men with hypertension unless blood pressure is managed first. Research has shown that testosterone could act directly on the kidneys through an autocrine or paracrine mechanism, stimulating sodium reabsorption along with increased water retention. This effect leads to a higher extracellular fluid volume, resulting in elevated blood pressure levels experienced by some men undergoing hormone therapy. Autocrine mechanism: Testosterone may act directly on the kidney cells that produce it, leading to an increase in sodium and water reabsorption. This process can contribute to elevated blood pressure levels by increasing extracellular fluid volume. Paracrine mechanism: Testosterone could also influence neighboring kidney cells through paracrine signaling, which involves the release of chemical messengers that travel short distances to affect nearby cells. In this case, testosterone might stimulate adjacent renal tubule cells responsible for regulating sodium and water balance within the body. In addition to these direct effects on kidney function, testosterone has been shown to impact other hormones involved in fluid regulation, such as aldosterone and vasopressin. For example, studies have found that men with low testosterone levels exhibit reduced aldosterone secretion, a hormone responsible for promoting sodium retention and potassium excretion by the kidneys. Consequently, when TRT is administered and testosterone levels rise again, there could be an associated increase in aldosterone production, resulting in greater sodium retention along with increased extracellular fluid volume. Taking Control of Blood Pressure During TRT If you are experiencing high blood pressure while undergoing TRT due to increased extracellular water retention caused by changes in renal function, hormonal imbalances related to treatment itself, or lifestyle factors like diet and exercise habits (as discussed earlier), it's essential to take proactive steps towards managing your condition effectively: Maintain regular check-ups with your healthcare provider. Your doctor will monitor your progress during TRT closely so they can adjust dosage if necessary or recommend additional interventions such as medication adjustments or lifestyle modifications aimed at reducing blood pressure levels. Monitor your blood pressure at home: Invest in a reliable home blood pressure monitor and take readings twice daily to keep track of any fluctuations that may occur during treatment. Maintain a healthy lifestyle: incorporate regular exercise, good hydration, a balanced diet low in sodium, limit alcohol consumption, and manage stress levels to help minimize the impact of TRT on blood pressure and overall health. In conclusion, understanding how testosterone impacts kidney function can provide valuable insights into managing high blood pressure during hormone therapy. By taking proactive steps towards maintaining optimal renal health while undergoing TRT, men can experience the benefits of this treatment without compromising their cardiovascular well-being.   Key Takeaway:  Testosterone replacement therapy (TRT) can lead to an increase in extracellular water retention, which contributes to elevated blood pressure levels. Testosterone impacts kidney function by stimulating sodium reabsorption and increasing water retention, resulting in a higher extracellular fluid volume that causes high blood pressure. To manage this condition effectively, it's essential to maintain regular check-ups with your healthcare provider, monitor your blood pressure at home, and maintain a healthy lifestyle. Estrogen Conversion May Not Be Responsible for Water Retention It was once believed that the increase in extracellular water (ECW) experienced by men undergoing testosterone replacement therapy (TRT) could be attributed to the conversion of testosterone into estrogen within peripheral tissues. However, recent research has debunked this hypothesis, indicating that other mechanisms must be at play when it comes to understanding how hormone treatments impact fluid balance within the body. In this section, we will explore why estrogen is not responsible for increased ECW and discuss alternative explanations for changes in fluid balance during TRT. Debunking Misconceptions about Estrogen's Role in ECW Increase The idea that estrogen might be responsible for increased ECW stemmed from its known effects on sodium and water retention. Indeed, studies have shown that elevated levels of estrogen can lead to an increase in total body water due to enhanced renal reabsorption of sodium and subsequent water retention. This led some researchers to speculate whether a similar mechanism might explain the observed rise in extracellular fluid volume among men receiving TRT. However, more recent investigations have demonstrated no significant correlation between circulating estradiol levels (the primary form of estrogen) and changes in extracellular fluid volume following testosterone administration. These findings imply that the aromatization, or conversion, of testosterone into estradiol cannot solely account for any increase in ECW experienced by men on TRT. Investigating Alternative Explanations for Changes in Fluid Balance In light of these discoveries, scientists are now considering other potential mechanisms that might account for the increase in ECW observed among men undergoing hormone therapy. One such possibility is that testosterone itself may directly affect kidney function, as discussed earlier in this article. Due to its modulation of secretion and action, testosterone levels may have an impact on vasopressin, a hormone that regulates the body's water balance.  Recent studies suggest that testosterone can also modulate vasopressin secretion. Vasopressin is a hormone that regulates water balance and blood pressure in the body. It is released from the pituitary gland and acts on the kidneys to regulate the amount of water excreted in urine. Research shows that testosterone can regulate the production and release of vasopressin in the hypothalamus, a region of the brain that plays a key role in regulating hormone secretion. Testosterone can enhance vasopressin secretion, which in turn can increase water reabsorption in the kidneys and reduce urine output. Therefore, testosterone can have an impact on the body's fluid balance, which can have implications for overall health and well-being. More research is needed to fully understand the complex relationship between testosterone and vasopressin secretion. A third hypothesis involves aldosterone, another hormone involved in maintaining proper electrolyte balance and blood pressure regulation.Testosterone has been found to stimulate aldosterone production, which could theoretically contribute to changes in ECW by promoting sodium retention and subsequent water reabsorption at the level of renal tubules. Another factor that may increase blood pressure is the effect of TRT on increasing red blood cells and hematocrit to high levels in some men.  High hematocrit can increase blood viscosity and blood pressure. In addition to these hormonal factors, it's important not to overlook lifestyle influences when examining changes in fluid balance during TRT. As mentioned previously, high-sodium diets, alcohol consumption, and a lack of exercise can all exacerbate water retention issues among men receiving hormone treatments. Moving Forward: The Importance of Ongoing Research While we now know that estrogen conversion is not responsible for increased ECW during TRT, there remains much work to be done when it comes to understanding how various factors influence fluid balance among individuals undergoing this form of therapy. Continued research into hormonal pathways - as well as individual differences related to both genetics and lifestyle choices - will help paint a clearer picture regarding how to best manage side effects like edema-related swelling while optimizing the overall benefits of TRT for men who need it. For now, it's essential that patients and healthcare providers alike remain vigilant when monitoring fluid balance during hormone therapy. By staying informed about the latest research findings and being proactive in addressing any potential issues related to water retention, men on TRT can minimize their risk of experiencing complications while maximizing the positive impact of treatment on their health and well-being.   Key Takeaway:  Recent research has debunked the hypothesis that estrogen is responsible for increased extracellular water (ECW) in men undergoing testosterone replacement therapy (TRT). Alternative explanations include direct effects of testosterone on kidney function, modulation of vasopressin secretion and action, and stimulation of aldosterone production. It's important to monitor fluid balance during hormone therapy and consider lifestyle influences such as high-sodium diets, alcohol consumption, and a lack of exercise. Lifestyle Factors Influencing Water Retention During TRT Men receiving testosterone replacement therapy (TRT) may experience increased water retention when consuming high-sodium foods, drinking alcohol, or skipping gym sessions for more than three days. Adjusting these lifestyle factors can help minimize the impact of TRT on blood pressure and fluid balance. The Role of Sodium Intake in Water Retention A diet high in sodium can cause your body to retain more water, leading to an increase in extracellular fluid volume. This is particularly true for men undergoing testosterone replacement therapy, as their bodies are already prone to retaining excess fluids due to the hormonal changes taking place. To combat this issue, it's essential that you monitor your daily sodium intake while on TRT. Limit processed foods: Processed and packaged foods often contain large amounts of hidden sodium. Opt for fresh fruits, vegetables, lean meats, and whole grains instead. Cook at home: Preparing meals at home allows you greater control over the amount of salt used in your dishes. Experiment with herbs and spices to add flavor without relying on salt. Read food labels: Pay attention to the nutritional information provided on food packaging so you're aware of how much sodium each product contains. Avoid dining out frequently: Restaurant meals tend to be higher in sodium compared to homemade options; limit eating out whenever possible. Effects of Alcohol Consumption on Fluid Balance In addition to increasing overall caloric intake and potentially contributing to weight gain, alcohol consumption can also have a negative impact on fluid balance in men undergoing TRT. Alcohol acts as a diuretic, causing your body to lose fluids and electrolytes through increased urine production. This loss of fluids can lead to dehydration, which may exacerbate blood pressure issues and water retention problems associated with testosterone therapy. To minimize the effects of alcohol on fluid balance during TRT: Limit alcohol intake: Aim for moderate drinking habits by consuming no more than two alcoholic beverages per day for men. Stay hydrated: Drink plenty of water throughout the day and especially when consuming alcohol to counteract its dehydrating effects. Avoid binge drinking: Consuming large amounts of alcohol in a short period increases the risk of dehydration and worsens blood pressure and water retention problems related to TRT. Importance of Regular Exercise During Hormone Therapy Maintaining an active lifestyle is crucial for overall health and well-being while undergoing hormone therapy. Regular exercise not only helps control weight gain but also plays a vital role in managing blood pressure levels and promoting healthy circulation. Additionally, physical activity has been shown to help reduce edema-related swelling caused by excess extracellular fluid buildup - one common side effect experienced by many men receiving testosterone treatment. Incorporate these tips into your fitness routine while on TRT: Create a consistent schedule: Aim for at least three days per week dedicated to cardiovascular exercises such as brisk walking, jogging, or swimming; consistency is key when it comes to maintaining optimal blood pressure levels during hormone therapy treatments like TRT. Incorporate strength training: Building muscle mass can help improve arterial stiffness and reduce the risk of cardiovascular disease and heart attacks. Monitor progress: Keep track of your progress and adjust your exercise routine as needed to ensure you're getting the most out of your workouts.   Key Takeaway:  Men undergoing testosterone replacement therapy (TRT) may experience increased water retention due to hormonal changes, which can impact blood pressure. To minimize the effects of TRT on fluid balance, it's important to monitor sodium intake, limit alcohol consumption, and maintain a regular exercise routine that includes both cardiovascular exercises and strength training. FAQs in Relation to TRT and Blood Pressure Does TRT therapy raise blood pressure? TRT therapy can potentially raise blood pressure in some individuals, especially if they have pre-existing hypertension or other cardiovascular risk factors. However, the effect varies from person to person and depends on individual health conditions and lifestyle factors. Regular monitoring of blood pressure is essential during TRT. Does testosterone play a role in blood pressure? Testosterone does play a role in regulating blood pressure by influencing vascular function, kidney function, and body fluid balance. However, its impact on an individual's blood pressure may vary depending on various factors such as age, overall health status,the presence of pre-existing metabolic syndrome or cardiovascular issues, hormone levels, and lifestyle choices. Can testosterone cypionate cause high blood pressure? Testosterone cypionate is a form of injectable testosterone used for TRT. It has the potential to cause high blood pressure in some men due to increased water retention or changes in renal function associated with higher testosterone levels. Monitoring your BP regularly while using this medication is important. Does low testosterone shots cause high blood pressure? Low-testosterone shots are typically administered as part of TRT when treating hypogonadism (low T). These injections can sometimes lead to elevated BP due to increased water retention or altered kidney functions; however, it doesn't happen universally among all patients undergoing treatment. Maintaining healthy habits like exercising regularly and reducing sodium intake will help mitigate the risks associated with elevated blood pressure. Conclusion Therefore, it is essential to monitor blood pressure regularly in order to avoid potential cardiovascular complications associated with TRT. Regular monitoring of blood pressure is crucial to preventing cardiovascular disease and other related health issues. While TRT can have a positive impact on muscle mass and metabolic syndrome, it's important to manage any side effects that may arise. If you're interested in learning more about the role of the pituitary and thyroid in the diagnosis and treatment of TRT blood pressure, check out this informative article from  Testosterone Wisdom. Take control of your health today by educating yourself on the benefits and risks associated with TRT blood pressure management!        

A Complete Blood Count (CBC) and a Comprehensive Metabolic Panel (CMP) are both common blood tests used to assess overall health, but they measure different components and provide distinct information. Here's a comparison of cbc vs cmp: Purpose and Components CBC Panel: Focus: Blood cell counts and characteristics Measures: Red blood cells, white blood cells, and platelets Includes: Hemoglobin and hematocrit levels Provides: Information about blood cell production and function CMP Panel: Assesses: Metabolic and chemical balance in the body Measures: Electrolytes, proteins, and enzymes Includes: Glucose levels and kidney/liver function tests Provides: A broader overview of organ function and metabolism Specific Tests Red blood cell count White blood cell count and differential Platelet count Hemoglobin Hematocrit Red blood cell indices (MCV, MCH, MCHC, RDW) Glucose Calcium Electrolytes (sodium, potassium, chloride, and carbon dioxide) Proteins (albumin, total protein) Kidney function (BUN, creatinine) Liver function (ALP, ALT, AST, bilirubin) Primary Uses Diagnosing blood disorders (e.g., anemia, leukemia) Detecting infections Monitoring overall health and immune system function Assessing blood loss or clotting issues Evaluating kidney and liver function Checking electrolyte and fluid balance Screening for diabetes Assessing overall metabolic health Preparation Generally no special preparation required Requires fasting for 12 hours before the test, especially for accurate glucose measurement [5] Number of Tests Typically includes about 10-12 measurements Consists of 14 specific tests[5] Interpretation Abnormalities may indicate blood disorders, infections, or other health issues Results are often interpreted alongside other tests for a comprehensive health assessment Provides insights into organ function, particularly the liver and kidneys Abnormal results may suggest metabolic disorders, electrolyte imbalances, or organ dysfunction In summary, while both tests are valuable for assessing overall health, the CBC focuses on blood cell components and related disorders, while the CMP provides a broader view of metabolic function and organ health. Healthcare providers often use these tests in combination for a more comprehensive evaluation of a patient's health status. Diagnostic Focus Focuses on: Metabolic and organ function[1] Assesses: Liver and kidney health Evaluates: Electrolyte balance and blood sugar levels Provides: Insight into overall metabolism Concentrates on: Blood cell components and characteristics[2] Assesses: Bone marrow function Evaluates: Oxygen-carrying capacity of blood Provides: Information about the immune system and clotting ability Specific Diagnostic Capabilities Diabetes screening and monitoring (glucose levels) Liver function assessment (ALT, AST, ALP, bilirubin) Kidney function evaluation (BUN, creatinine) Electrolyte imbalances (sodium, potassium, chloride, bicarbonate) Protein levels and nutritional status (albumin, total protein) Anemia diagnosis and classification Infection detection (elevated white blood cell count) Blood disorders like leukemia or lymphoma Platelet abnormalities and clotting disorders Bone marrow function assessment Organ Systems Evaluated Primarily assesses liver, kidney, and pancreas function Provides insight into overall metabolic health Primarily evaluates the hematological system Indirectly reflects bone marrow function and immune system status Number of Components Measures 14 different substances in the blood [1] Typically includes 5-7 main components, with additional calculated values [4] Preparation and Procedure Requires fasting for 12 hours for accurate glucose measurement [1] Generally does not require fasting [4] CBC vs CMP: Complementary Nature While the CMP and CBC panels differ in their focus, they are often ordered together to provide a more comprehensive picture of a patient's health. The CMP offers insight into metabolic processes and organ function, while the CBC provides crucial information about blood cell production and function. Together, they offer a broader view of overall health status and can help identify a wide range of medical conditions. In summary, the CMP panel is better suited for assessing metabolic health, liver and kidney function, and electrolyte balance, while the CBC panel excels in diagnosing blood disorders, infections, and evaluating overall blood cell health. Both tests are valuable tools in medical diagnostics, often used in conjunction to provide a more complete health assessment. Citations Complete Blood Count - Wikipedia Complete Blood Count - Mayo Clinic Complete Blood Count - Labcorp Comprehensive Metabolic Panel - Wikipedia Comprehensive Metabolic Panel - Cleveland Clinic How to Read Comprehensive Metabolic Panel - Kidney Foundation Comprehensive Metabolic Panel - MedlinePlus Comprehensive Metabolic Panel - Testing.com Complete Blood Count - Testing.com Complete Blood Count - WebMD

Table of Contents 10 Top Hormone Panels You Can Order Today 1.   Hormone Panel for Men on TRT 2.   Women's Hormone Panel 3.   Basic Bodybuilder Panel 4.   Comprehensive Bodybuilder Panel 5.   Men/Women Hormone and Wellness Panels 6.   Ultimate Lab Test Panel for Men and Women 7.   Testosterone Panels 8.   Thyroid Panel 9.   Gynecomastia Panel 10.                Erectile Dysfunction Panel 20 Individual Labs Money Can Buy Today 1.   Anti-Mullerian Hormone Test 2.   Free Estradiol (Sensitive) 3.   Thyroxine-Binding Globulin 4.   Growth Hormone 5.   Cortisol Test 6.   Insulin-Like Growth Factor-Binding Protein 3 7.   ACTH Plasma Test 8.   Aldosterone Test 9.   Fasting Insulin 10.  Parathyroid Hormone PTH Test 11.   Prolactin Test 12.                DHEA-Sulfate Test 13.                DHT Test 14.                Sex Hormone-Binding Globulin 15.                LH and FSH Test 16.                Estrone Test 17.                Progesterone Test 18.                Insulin-Like Growth Factor 1 19.                Pregnenolone Test 20.                Thyroid-Stimulating Hormone   Order a Hormone Test Today! Hormones, enzymes, and other substances set the human body's intricate machinery in motion. Hormones are some of the most important elements, and they travel throughout your entire body to influence the function of organs and tissues. A hormone is basically a chemical messenger. Testing these hormones helps you find out important information about your health. Luckily, today's medical technology is able to identify and test more than 50 different hormones in the human body. Keep reading to learn more about hormone tests and why you should order them. This article provides you with valuable information on individual hormone tests as well as complex hormone panels. 10 Top Hormone Panels You Can Order Today Hormone panels are collections of hormones tested together to find out if you're struggling with some sort of deficiency or disease. In many cases, it's required to test more than one hormone to see if you have a thyroid problem, for example. A testosterone panel is another good example in this case. This type of panel usually allows you to test your total testosterone as well as its fractions, such as free testosterone, albumin-bound testosterone, or SHBG-bound testosterone. Here are some of the most popular hormone panels you can buy: 1.   Hormone Panel for Men on TRT Testosterone replacement therapy is increasingly popular in the United States and other developed countries around the world. It involves getting testosterone exogenously using creams, injections, pellets, nasal gels, orals, and other methods. This therapy is suitable for hypogonadal men, but it requires adequate monitoring and adjustments. The Hormone Panel for Men on TRT will test your DHEA levels as well as ultrasensitive estradiol, pregnenolone, progesterone, DHT, prolactin, total testosterone, and other hormones. Keeping track of all these hormones will increase your success with TRT. 2.   Women's Hormone Panel This panel is designed for women, and it contains a plethora of hormones as well. For example, you get a DHEA test as well as progesterone, pregnenolone, and testosterone tests. Included in this panel are also a few thyroid hormone tests, such as T3 and T4. You can also add LH and FSH tests separately if you want to. 3.   Basic Bodybuilder Panel Bodybuilders need to monitor their hormones to avoid polycythemia, which is a condition that involves blood thickening. The basic bodybuilding panel includes multiple hormone tests, such as total and free testosterone, hematocrit tests, a complete metabolic panel, and more. If you just started with bodybuilding, this panel would provide you with accurate insight into how your body is performing. It's important to keep track of all these hormones to avoid the risks commonly associated with bodybuilding. 4.   Comprehensive Bodybuilder Panel More experienced bodybuilders need to monitor additional hormones. This panel includes 14 different tests. Apart from the ones mentioned in the basic bodybuilding panel, this collection of tests also includes ferritin, a complete blood count, and IGF-1 labs, among others. The comprehensive bodybuilder panel is suitable for experienced bodybuilders as well as novice ones that want to keep all their hormones under control. 5.   Men/Women Hormone and Wellness Panels These panels are relatively similar, and they contain a plethora of hormone tests suitable for men and women alike. For example, the panels include a complete blood count, thyroid tests, liver, and kidney tests, as well as labs for sex hormones such as testosterone and estrogen. If you want a complete snapshot of your health, the men's or women's wellness panels are probably your safest bet and they provide excellent value for money. 6.   Ultimate Lab Test Panel for Men and Women This is probably the most comprehensive direct-to-consumer lab panel money can buy today. It's suitable for both men and women and it includes tests for your kidneys, liver, vitamin D deficiency, iron, inflammation biomarkers, sex hormones, thyroid hormones, etc. This type of panel is suitable for those who want to get a complete overview of their health. It will also save you a lot of money in comparison with ordering this collection of tests separately. 7.   Testosterone Panels You might be happy to find out that there are also various testosterone panels you can buy. The most basic one tests your testosterone and its fractions. However, some panels are a little bit more complex, and they can also test your estradiol, DHT, PSA, hematocrit, and/or prolactin levels. These panels are suitable for people on TRT who need to keep their hormones in check. For example, if you're worried about prostate problems, order the Testosterone + PSA panel to see if your prostate-specific antigen is too high. 8.   Thyroid Panel The thyroid gland is complex and important. It secretes hormones such as T3 and T4 which influence your entire body. Most thyroid panels test your T3, T4, as well as TSH (thyroid-stimulating hormone). This panel will help you diagnose any thyroid problem you might have and it saves you money in comparison with ordering thyroid tests separately. 9.   Gynecomastia Panel Gynecomastia is also known colloquially as "man boobs" and this condition might affect certain men on TRT. This happens when too much testosterone is converted into estrogen. The gynecomastia panel includes tests for testosterone, estradiol, DHT, prolactin, and other hormones. 10.                Erectile Dysfunction Panel ED is relatively common among hypogonadal men. It involves the inability to have an erection or maintain it to achieve satisfying intercourse. The ED panel includes tests for hormones that could be the cause of your ED such as testosterone, estradiol, thyroid hormones, DHEA, and others. If you currently struggle with erectile dysfunction, this panel might provide an insight into what treatment to follow to cure this problem. These are some of the most common hormone panels you can buy, and each one of them provides excellent value for money. Now it's easier than ever to find out exactly what your hormone levels are and what treatment options you have to improve them if necessary. 20 Individual Labs Money Can Buy Today We talked about complex hormone panels, but individual tests for specific hormones are equally important. Let's take a look at some of the most popular hormone tests you can use to learn more about your general health. 1.   Anti-Mullerian Hormone Test The anti-Mullerian hormone is important when assessing fertility status and ovarian function. Low levels of this hormone are related to difficulties conceiving a baby. Women might want to order this test to see if they currently struggle with unknown fertility issues. 2.   Free Estradiol (Sensitive) Estradiol is a female sex hormone with an important role in both men and women. This test uses LC/MS testing methods to determine your free estradiol levels as accurately as possible. Men on TRT, among others, might want to order this test to keep their estradiol in check. 3.   Thyroxine-Binding Globulin Thyroxine-binding globulin (TBG) links to thyroid hormones and helps them circulate freely in the body. Low levels of TBG don't show symptoms but could indicate underlying thyroid issues. You might need a TBG test to determine if you struggle with hypothyroidism or hyperthyroidism. 4.   Growth Hormone The growth hormone is important for muscle gain, exercise performance, and wound healing. A growth hormone blood test tells you if you have healthy levels of this substance or not. You might want to order this test if you fail to see muscle hypertrophy or if you feel lethargic all the time. 5.   Cortisol Test Cortisol is one of the main "stress" hormones in the body. It's secreted by your adrenal glands in response to various stimuli. You can order a salivary or blood cortisol test. This information is useful in assessing the risk for more complicated diseases that can be caused by excessive stress. 6.   Insulin-Like Growth Factor-Binding Protein 3 This hormone is an important carrier of IGF-1 and it's required to determine if you're producing healthy levels of human growth hormone. If this test returns abnormal results, your pituitary gland might not function correctly. 7.   ACTH Plasma Test ACTH stands for adrenal corticotropic hormone. It's a hormone produced by the pituitary to maintain the cortisol balance in your body. You might need an ACTH plasma test to see if you struggle with any diseases caused by too much or too little cortisol. 8.   Aldosterone Test Aldosterone helps adjust the mineral balance in your system. It maintains sodium and potassium levels in a healthy range. Excessive aldosterone is also associated with serious cardiovascular complications. You might need this test if your blood pressure is high most of the time. 9.   Fasting Insulin Insulin is a hormone secreted by the pancreas. It helps move blood sugar into cells to produce energy. A fasting insulin test is required to determine if you're predisposed to diabetes which is a life-threatening disease. 10.  Parathyroid Hormone PTH Test This hormone is released by the parathyroid glands. It maintains healthy calcium levels in your system. If you currently struggle with hypocalcemia, your doctor might order a parathyroid hormone test. This hormone is also helpful in diagnosing thyroid problems. 11.   Prolactin Test Prolactin is known to support lactation in women, but it also plays other important functions. For example, it plays a role in immune function and supports the production of testosterone by the Leydig cells. However, too much prolactin might lead to sexual dysfunction in men. 12.                DHEA-Sulfate Test DHEA-Sulfate is produced by the adrenal glands and it plays a vital role in the production of both male and female sex hormones. Abnormal levels of this hormone might indicate hormonal disorders. A DHEA test is required to find out if a patient is struggling with neurodegenerative disorders, excessive inflammation, etc. 13.                DHT Test Dihydrotestosterone is similar to testosterone. Too much of it can lead to hair loss and acne. Too little DHT might lead to sexual dysfunction. This test helps you find out if your DHT levels are within normal ranges. 14.                Sex Hormone-Binding Globulin SHBG is a protein carrier for testosterone. Most of the testosterone in the body is bound to SHBG. High levels of this hormone might indicate thyroid problems or anorexia. Too little SHBG is commonly associated with diabetes and ovarian complications. 15.                LH and FSH Test Luteinizing hormone and follicle-stimulating hormone are produced by the pituitary gland. These hormones indicate the onset of menopause in women and andropause in men. Low levels of these two hormones could also indicate that there is too much estrogen in your body. 16.                Estrone Test Estrone is one of the most important estrogens found in a woman's body. Its levels increase after menopause. Testing estrone might be required to prevent osteoporosis and other health problems commonly associated with post-menopausal women. 17.                Progesterone Test This is another important female sex hormone. It's also present in a male's body, but very small quantities. High levels of progesterone are commonly associated with depression, bloating, and other symptoms in women. 18.                Insulin-Like Growth Factor 1 IGF-1 is used to gauge the blood levels of human growth hormone in both men and women. This hormone is very similar to insulin when it comes to its structure. Your doctor might order an IGF-1 test to determine if your growth hormone is within normal ranges. 19.                Pregnenolone Test Pregnenolone is the hormone from which all other hormones are made, including estrogen and testosterone. Abnormal levels of pregnenolone might affect your mood, cognition, memory, and metabolism. This test uses LC/MS to accurately determine the levels of pregnenolone in your body. 20.                Thyroid-Stimulating Hormone The TSH is exactly what the name implies - a hormone that stimulates your thyroid to produce other hormones. This substance is secreted by the pituitary gland and it helps doctors determine if you have a thyroid problem. Order a Hormone Test Today! As you can see, there are numerous hormone panels and individual tests you can order from a reputable vendor. When you order a test, you are mailed a form that you use to go to a nearby clinic to draw a blood sample. This sample is analyzed in a laboratory and you get the results by mail in just a few business days. Your results are confidential and not shared with anyone. These results can be compared with reference values or you can ask your doctor to help you interpret them. Go to DiscountedLabs.com today and order your favorite test to find out more about your health!

How to Safely Use PCT After TRT: Stopping Testosterone Replacement Therapy Table of Contents What is Post Cycle Therapy PCT? Why Do Men Stop TRT? Common reasons a man may need to discontinue TRT include: Normalizing Natural Testosterone After Stopping TRT PCT Treatments to Jump Start Natural Testosterone and Sperm Production How to Know if Your PCT Worked? Buy Discounted Lab's Post-PCT Panel  References: There is a common phrase most men will hear when they consider testosterone replacement therapy (TRT); it may be something they hear from friends or often what they read online: "TRT is for life." There is an element of truth to this statement: when a man has low testosterone, in order to treat it and maintain healthy or optimal levels, he will always need TRT to achieve it. However, saying "it's for life" remains a somewhat inaccurate statement, and this is where we enter into the realm of what is commonly referred to as Post Cycle Therapy or PCT. TRT and anabolic androgenic steroids (AAS) can lead to dysfunction in HPTA (Hypothalamic-Pituitary-Testicular Axis). Supplemental testosterone can inhibit the release of the body's own testosterone production through negative feedback inhibition on LH levels. This feedback inhibition also results in the suppression of FSH levels, leading to the suppression of sperm production (spermatogenesis). During recent years a large surge in testosterone prescriptions and TRT clinics has unfortunately led to many men who have been misdiagnosed with low testosterone yet placed on TRT when it may not have been needed in the first place. If you are one of these men and you are considering discontinuing testosterone treatments, some protocols can help restore your hormone axis. You do not want to stop testosterone "cold turkey," which will lead to unnecessary symptoms that could last for many months. Understanding TRT and Its Impact on the Body Testosterone Replacement Therapy (TRT) can be a game-changer for men with low testosterone levels, but it's crucial to understand how it impacts the body. TRT involves introducing exogenous testosterone into the body, which can disrupt the natural hormone production process. To grasp the full picture, we need to explore the Hypothalamic-Pituitary-Testicular Axis (HPTA) and how TRT affects it. The Hypothalamic-Pituitary-Testicular Axis and TRT The Hypothalamic-Pituitary-Testicular Axis (HPTA) is a sophisticated system that regulates testosterone production. It starts with the hypothalamus, which produces Gonadotropin-Releasing Hormone (GnRH). This hormone signals the pituitary gland to release Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). LH and FSH then stimulate the testes to produce testosterone. When you undergo Testosterone Replacement Therapy (TRT), this delicate balance can be disrupted. The introduction of exogenous testosterone can suppress the body's natural production of LH and FSH, leading to a decrease in the body's ability to produce testosterone on its own. Impact of TRT on Natural Testosterone Production The impact of TRT on natural testosterone production can be significant. When exogenous testosterone is introduced, it can lead to a suppression of LH and FSH, which are crucial for natural testosterone production. This suppression can result in various symptoms, such as low libido, fatigue, and decreased muscle mass. Over time, prolonged use of TRT can lead to hypogonadism, a condition where the testes are unable to produce sufficient testosterone. This is why understanding the effects of TRT on natural hormone production is essential for anyone considering or currently undergoing TRT. What is Post Cycle Therapy PCT? PCT is a treatment plan after discontinuing anabolic androgenic steroids (AAS). It is a phrase most commonly associated with what we might call "recreational steroid users" (RSU), such as bodybuilders: people who do not need steroid hormones like testosterone for medical reasons but use them for muscular competition advantage. In such cases, the individual will supplement with AAS for a set period of time, known as a steroid cycle, and then discontinue use. As his use of AAS shut down his natural testosterone production, just as it does with TRT, he will often implement a PCT plan for natural production to restart. Such plans will include Selective Estrogen Receptor Modulators (SERMs) or other items, such as the peptide HCG. The goal for the RSU, as eluded to prior, is to regain his natural production of testosterone as quickly and efficiently as possible. There is no guarantee this will work. There is no guarantee he will reach his previous levels before AAS use, although perhaps levels that accurate enough. Then we have the TRT patient; such an individual had low testosterone levels before he began administering exogenous testosterone. The use of testosterone, just as it did with the RSU, will stop his natural production. This is a factor that bothers many men, but let us keep in mind a very significant one: you already had low levels, your body was not able to produce enough, to begin with, and was not going to be able to, or you wouldn't be on TRT. Nonetheless, there are reasons some men may find they need to discontinue use, and when that occurs, a PCT plan may be in order. Such a plan will not address his primary issue, low testosterone, but the goal here is to get at least some natural production back online. Why Do Men Stop Testosterone Replacement Therapy? Common reasons a man may need to discontinue TRT include: Need for Fertility TRT Cost TRT Side Effects or Health Issues Of the three potential reasons to stop TRT, fertility is the overwhelming reason for most men. Along with suppressing natural testosterone production, TRT can also have a negative impact on sperm production. There was a time in history not that long ago when it was thought exogenous testosterone would be touted as a male contraceptive. This idea died out when many men using testosterone found they were still able to impregnate a female. While many men on testosterone were found to be severely lacking in this department, it wasn't enough or significant enough to market the hormone as an actual contraceptive. The other common reasons for discontinuing TRT are cost and side effects. These are the least common reasons in comparison to fertility needs or desires, but both are still possible. We all go through points in life where money can get a little tight; loss of a job, unexpected expenses – whatever the reason, if you find you need to stop, considering a PCT plan with your physician will make the transition easier. You're still going to have low testosterone levels in the end – remember, you already had them, or you wouldn't have started TRT in the first place – but you'll hopefully be in a better position than you would be without, and in time, when your situation improves, you'll be able to jump back on your TRT plan. The same may hold true for the individual who has side effect issues. This will be the least common reason for discontinuation of TRT but certainly within the realm of possibility. You could be one of the rare individuals who cannot control his hematocrit even with regular therapeutic phlebotomy. You could be someone that has other health concerns and, for whatever reason, need to discontinue use until you figure out what's going on with your body. Hormonal imbalances, such as elevated estrogen levels, can also occur when stopping TRT, leading to conditions like gynecomastia. As was with the individual who was experiencing income issues, a PCT plan may be in order. Preparing for TRT Discontinuation Deciding to discontinue TRT is a significant step and should be approached with caution. One of the most critical aspects of stopping TRT safely is to do so under the guidance of a medical professional. Abruptly stopping TRT can lead to severe withdrawal symptoms and a dramatic drop in testosterone levels, which can be detrimental to your health. Gradual Tapering Under Medical Supervision When it comes to discontinuing TRT, gradual tapering is the safest approach. This process involves slowly reducing the dosage and frequency of testosterone administration to allow the body to adjust and begin producing testosterone naturally again. A healthcare provider can create a personalized tapering schedule based on factors such as the dosage and duration of your TRT use. This might involve reducing the amount of testosterone you inject or apply through gels over a set period. Regular check-ups with your healthcare provider are crucial during this time to monitor your progress and make any necessary adjustments to your tapering plan. This careful and monitored approach helps minimize withdrawal symptoms and supports the body's natural transition back to producing testosterone on its own. By understanding the impact of TRT on your body and following a medically supervised tapering plan, you can safely discontinue TRT and support your body's return to natural testosterone production. Normalizing Natural Testosterone After Stopping TRT For most men, studies have shown that for men who stop TRT, natural testosterone production can normalize within three months or longer, and spermiogenesis in well over a year. This is certainly not optimal when conception is the goal, which leads to the possible need for a PCT protocol. Post cycle therapy (PCT) is crucial in maintaining and recovering natural testosterone levels after using performance-enhancing drugs, as it helps enhance the body's own testosterone production. PCT Treatments to Restore Hormonal Balance and Jump Start Natural Testosterone and Sperm Production The use of the SERMs has been shown to increase testosterone levels to baseline in as little as 2-4 weeks. Studies have also shown spermiogenesis to improve significantly within 3-6 months. Clomid as we can easily see, greatly improves the time frames of recovery of these two important factors related to conceiving (testosterone and semen). PCT is crucial to restore hormonal balance, helping individuals recover from the use of anabolic steroids by promoting natural testosterone production and mitigating adverse effects caused by hormonal imbalances. HCG is another item commonly used in PCT for fertility purposes. HCG PCT has the ability to stimulate both testosterone production and spermiogenesis. It is not uncommon for fertility specialists to try both Clomid and HCG and, in some cases, in conjunction with one another. Unfortunately, there is much controversy among many fertility specialists regarding how much HCG should be administered for this purpose. While many physicians will prescribe SERMs in the range of 25-50mg per day to every other day, commonly prescribed HCG doses can run anywhere from 1000iu per day to 2500iu or even larger doses split into every other day schedules. Other common drugs used in this treatment, but to a lesser extent, include the SERM Tamoxifen Citrate, best known by its most notable trade name, Nolvadex. Treatments usually requires 4 weeks. Unfortunately, for some men, a PCT plan that includes some or all of these medications will not work. A HCG PCT plan is most likely to work in a TRT patient who is receiving treatment due to secondary hypogonadism. If a PCT plan has not worked – testosterone levels and sperm count have not increased – it is likely that the individual has primary hypogonadism, and as a result, will be best served (quality of life) by remaining on TRT. It's imperative to note: this individual had primary hypogonadism prior to beginning TRT, he did not obtain it because of TRT. How to Know if Your PCT Worked? After going through PCT, physicians tend to check your testosterone blood levels and upstream hormones like LH and FSH to determine if your hormone axis has been restored. Discounted Labs has created a Post PCT Lab Test Panel that makes it easy for men to know if their PCT has successfully worked. This lab test panel is designed to measure the health and recovery of the Hypothalamic-Pituitary-Testicular Axis (HPTA) after attempting to normalize it spontaneously or with the use of Post Cycle Therapy (PCT) (with the use of clomiphene, hCG, and other treatments) It is suggested that this panel be done no sooner than 4 weeks after PCT cessation and in a fasting state. You should fast for 12 hours before collection of the specimen. Fasting is defined as no consumption of food or beverage other than water for at least 12 hours before testing. If using a testosterone cream please be sure you have not rubbed any into the antecubital area of your arm for the last 24 hours as it can give elevated results. Lab tests included in the post-PCTest Panel: Ultra Sensitive Estradiol Test by Liquid Chromatography/Mass Spectrometry (LC/MS assay used to measure estradiol in men more accurately estradiol in men) Total and Free Testosterone LC/MS- No upper limit Luteinizing Hormone (LH) (responsible for activating Leydig testicular cells to produce your own testosterone). This hormone is shut down by testosterone replacement or AAS. Follicle Stimulating Hormone (FSH) (Responsible for activating Sertoli testicular cells to produce sperm). This hormone is shut down by testosterone replacement or AAS. CBC - Complete Blood Count (Includes hematocrit- red blood cell volume) CMP - Comprehensive Metabolic Panel (Includes liver and kidney function, glucose and electrolytes) For any man, simply discontinuing the use of testosterone can be difficult, to put it mildly. Your testosterone levels will completely bottom out when going the cold-turkey route, and this often. This severe sexual dysfunction, decreased energy, and even depression, to name a few of the consequences. Your levels may go up enough to at least function, to a degree, but it's going to take an enormous amount of time, as previously discussed. Cutting this time down significantly, and giving your body a boost in testosterone during the therapy process, is the only means of discontinuation that makes any sense, meaning some form of a PCT plan is a sensible approach. Buy Discounted Lab's Post-PCT Panel  References: Diagnosis and Management of Anabolic Androgenic Steroid Use Testosterone Use in the Male Infertility Population: Prescribing Patterns and Effects on Semen and Hormonal Parameters How to Stop TRT Safely

Table of Contents 1. Biotin Biotin Uses and Supplementation How Biotin Affects Test Results What Are the Lab Tests Which Might Be Affected by Biotin Supplementation? What Supplements Have Biotin? 2. Age 3. Urinary Tract Infection 4. Prostate Procedures 5. Bicycle Riding 6. Obesity or High Body Weight 7. Medications 8. Biological Rhythms 9. Pregnancy 10. Food and Water 11. Caffeine, Alcohol, and Tobacco 12. Exercise Get Your Health Checked Up Today!   According to the World Health Organization, chronic diseases kill millions of people each year. Diabetes alone accounted for nearly 1.6 million deaths in 2015. Deaths caused by neurodegenerative diseases such as dementia doubled since 2000, and this number is expected to grow in the upcoming years. Although these are alarming facts, you might be happy to find out that numerous diseases and injuries, particularly chronic illnesses, can be prevented. To prevent a disease, you first need to be aware of it. To be aware of it, you need to do the right thing and get your health checked periodically. Discovering a predisposition to the disease earlier on gives you a massive advantage. You'll be able to follow special treatments and minimize its risks or eliminate them. But how to get tested for various diseases which might affect you? Well, one of the simplest and most efficient ways is by using direct-to-consumer labs. These are usually discount labs you can purchase online at affordable prices and have your general health checked in a matter of days. No doctor visit is required so that you can quickly check your blood tests and monitor your health if you are an educated patient. However, you need to keep in mind that there are many factors which can influence the results of your lab tests. In other words, these factors can reduce the accuracy of your results, and that's why you need to follow up the doctor's advice before drawing blood for testing. This article is going to offer you a broader understanding when it comes to factors which influence lab tests. Keep reading to learn more about your health and how you can optimize the results of your lab work investigations. 1. Biotin Biotin is also known as vitamin B7 or vitamin H. This is a coenzyme the body needs for different metabolic processes. For example, the body needs biotin to optimize the metabolism of fat, carbohydrates, and protein. At the same time, biotin is also needed for the production of certain hormones. You can find biotin in fish, eggs, meat and certain vegetables such as spinach and broccoli. However, you can also take biotin supplements if needed. Adults need about 30 micrograms of biotin per day. Having more biotin in your system is not a problem, but it might affect some lab tests you make. For example, it can interfere with the results in certain blood tests, which might lead to an incorrect diagnosis of various health ailments. Biotin Uses and Supplementation As mentioned earlier, biotin is present in various pills and supplements you can buy online. For example, biotin can be used for treating alopecia, which is a health condition that makes people lose their hair. Doctors prescribe a dose of 5,000 to 10,000 micrograms of biotin per day to treat such health problems. At the same time, biotin can also be prescribed to pregnant women to support the healthy development of the baby. There are studies performed by researchers at various universities which prescribe large biotin doses to treat various problems with the nervous system. For example, multiple sclerosis might be treated with around 300,000 micrograms of biotin per day. Some people also use biotin to treat nail and skin problems since no studies are suggesting that a high amount of biotin can lead to health complications or injuries. How Biotin Affects Test Results Although supplementing with biotin can be beneficial for the body, this substance can greatly interfere with test results. The FDA (Food and Drug Administration) mentioned that biotin could alter blood test results and cause incorrect diagnosis for certain health conditions. It is recommended that you stop biotin supplementation at least 72 hours before offering a blood or saliva sample. What Are the Lab Tests Which Might Be Affected by Biotin Supplementation? There are many blood tests which can be affected by excessive biotin levels in your bloodstream. Some of these tests include vitamin D tests, any tests which measure the thyroid hormones in your body as well as tests which look at the FSH and LH hormones. Troponin is another type of test commonly used to diagnose heart attacks and other problems related to the cardiovascular system. If you're planning to do such blood tests in the future, make sure you put your biotin supplementation on hold to ensure you get accurate results. What Supplements Have Biotin? On top of getting biotin from your foods, this substance can also be taken from various vitamins or supplements available in drug stores. For example, most multivitamin pills, B-complex vitamins, and coenzyme R have high amounts of biotin in them. Similarly, supplements with vitamin H and prenatal vitamins might also contain biotin. If you're taking some supplements for hair growth and skin improvement, chances are that you're also getting some biotin from those. Look on the labels of the supplements you take and look for "biotin," "vitamin B7", "vitamin H," or "coenzyme R" to see if your pills contain biotin. If you have been instructed to stop biotin supplementation a few days before your blood test but forgot to do so, make sure that you inform your doctor about it. Your health practitioner needs to know this is the case your results show inaccurate or confusing results. 2. Age The advancing age of a patient also significantly influences the results of a particular blood test. In most cases, people of an elderly age tend to receive a higher percentage of incorrect/inaccurate results in comparison with younger adults. That's because certain hormones and substances in the body are interpreted differently by lab tests as their levels increase or decrease with age. To give you an accurate example, a lipid panel of an older adult is much different than the one of a young person. The levels of triglycerides, good cholesterol, and bad cholesterol tend to increase with age up to about 55-60 years in males and around 65 years in females. Some studies show that triglyceride levels continue to increase in senior females. When this happens, doctors don't use reference values based on age anymore because they are inefficient in people of elderly age. Instead, they test the risk of cardiovascular disease and formulate treatment options based on that because this method is much more efficient. At the same time, there are blood tests which measure the prostate-specific antigen (PSA) levels in men. PSA can increase in people of an elderly age as more PSA gets into the bloodstream and interferes with the test results. 3. Urinary Tract Infection Another factor that can influence the results of a PSA test consists of urinary tract infections. Various urinary tract bacteria can drastically alter the test results and lead to inaccurate diagnosis. That's why it's a good idea to tell your doctor if you ever had urinary tract infections so he can make a more accurate diagnosis when testing your PSA levels. 4. Prostate Procedures People who have had prostate procedures done are more likely to receive an incorrect diagnosis when doing prostate tests. For example, prostate surgery or biopsy, as well as prostatitis, can cause abnormal levels of PSA in the body. These factors can interfere with test results and cause false diagnosis. The doctor will eventually inform you when it's a good time to have a prostate test after you have had done a prostate surgery or biopsy. 5. Bicycle Riding Some studies have found that riding a bicycle can put a lot of pressure on the prostate, which can increase PSA levels. Therefore, prostate test results can come back with incorrect information, which leads to a false diagnosis. Another thing that can increase PSA levels is ejaculation since it makes more PSA leak into the bloodstream and affects the test results. 6. Obesity or High Body Weight Obesity is another health issue that affects the results of various blood tests. For example, obese men have greater BMI, and they usually have lower PSA concentrations. That's because obese men usually have a larger blood volume where PSA can get diluted. As a result, a prostate test can return false PSA results which affect the diagnosis set by the doctor. Similarly, obesity can also affect the results of rheumatoid arthritis tests. During those tests, various inflammatory markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are checked to detect the level of inflammation in the body. Some studies show that obese people tend to have higher levels of ESR and CRP in their bodies, and this can interfere with the results, leading to false diagnosis. Buy a CRP Test Here Another blood test that can be affected by body weight is creatinine (used to assess kidney function). This test result may be artificially elevated in people with higher body weight or lean mass.  Cystatin C may be a better indicator of kidney function in those patients. 7. Medications Any medication that you might take before doing a blood test can significantly influence the results. Make sure that you inform your doctor about the pills you take, so he can take that into account when interpreting the results. If it is possible, you can discontinue certain medication (after you have received doctor's approval) to make sure that your blood tests are more accurate. There are many types of medications which can influence the results of blood tests, including prostate test, inflammation tests, etc. For example, nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and naproxen can alter the results of a blood test. Other important ones include blood pressure medication, which is known as thiazide diuretics. Some of the most common medication in this category include hydrochlorothiazide, chlorothiazide, and others. These medications tend to lower PSA levels and lead to a false diagnosis in prostate blood tests. 5-alpha reductase inhibitors also affect PSA levels. These inhibitors are represented by dutasteride and finasteride, which also decrease the PSA levels by almost 50 %. Metformin, a popular diabetes drug that is gaining anti-aging interest, can reduce B vitamin blood levels. This fact needs to be considered when testing for B-12 or other vitamins. 8. Biological Rhythms Various hormones and other substances in the body have significantly different levels at certain moments of the day. For example, you have different cortisol or testosterone levels in the morning compared with those in the evening. That's why it's important to do certain tests at specific moments of the day to ensure the accuracy of the test. Your doctor will usually inform you about that and tell you when it's the best time for a blood test. Testosterone blood levels peak early in the morning, usually between 7 am, and 9 am. This time of the day is when a testosterone blood test should be done. Throughout the day, testosterone levels slowly decrease, and by evening, they are about two times lower than in the morning. The same story goes for cortisol levels as well. The levels of cortisol in your body peak early in the morning, and they gradually decline by 50%-100% until the end of the day. The time of the month or year is also very important when doing health checkups. For example, getting more vitamin D into your body relies on how much you are exposed to the sun. You can also get supplements with vitamin D if necessary, but sun exposure is one of the best and most efficient ways to get vitamin D. The levels of this vitamin in your bloodstream need to be interpreted based on the time of the year. For example, it's normal to have the lowest levels of vitamin D during winter times since that's when sun exposure is limited. 9. Pregnancy A pregnant woman can also have different test results in comparison with one who isn't pregnant. Pregnancy can change the amount of blood in the body, influence liver hormones, renal function, and other metabolic processes. Changes in hormone levels depend on the pregnancy stage, and they are usually compared against reference values. Physicians can give a pregnant woman more information on how to interpret these results and what they should do about them. 10. Food and Water The foods you eat and beverages you drink can influence the results of blood tests. For example, fasting, restricting calories, or being dehydrated can lead to incorrect test results and false diagnosis. To give you an example, a diet rich in protein can lead to increased uric acid levels, and this will be shown in various blood and urine tests. Similarly, a diet which is low in carbohydrates can increase the levels of ketones (ketogenic diet). If a person is a vegan or vegetarian, the levels of vitamin B12 in his/her bloodstream will be low. Some studies have shown that carbohydrates can temporarily decrease testosterone blood levels, so it is important to measure testosterone before breakfast. Fasting is needed before drawing blood for most blood testing. Patients are usually asked to fast for about 12-14 hours before doing a blood test. Fasting is important when checking lipid levels, blood sugar levels, some hormones, and substances in the body. Not fasting before a CMP test, for example, can lead to an incorrect diagnosis of diabetes type 2 since glucose can be elevated, which is a life-threatening condition if not treated properly. The Lipid Panel test (Triglycerides, LDL and HDL cholesterol) also requires fasting.  Failure to do so may cause the triglycerides value to be higher than normal. For more information about which tests require fasting, read: Fasting Blood Tests - Everything You Need to Know Dehydration also plays a vital role when it comes to blood testing. It can increase blood test values by decreasing the water content of the blood. It can be seen as an imbalance in sodium and potassium levels and lead to false diagnosis. For example, dehydration can affect albumin levels, blood lipids, creatinine (kidney), hematocrit, and some hormones in the body. 11. Caffeine, Alcohol, and Tobacco Drinking a lot of caffeine from coffee or green tea can also affect some blood test results. Although more studies are necessary when it comes to caffeine, there is a chance that this substance can alter blood glucose levels and temporarily increase them. Caffeine usually passes through the body in around 5 hours, so its effects are less significant in comparison with other substances. Caffeine can also affect hydration, a factor mentioned above. Last but not least, caffeine can increase blood pressure in some people. The lab technician may be alarmed about your blood pressure before drawing your blood. Alcohol, on the other hand, has a more significant effect on blood tests, depending on how much is consumed and when. For example, this substance might lower serum glucose levels in people of all ages and increase plasma lactate. These changes can happen, especially if alcohol is consumed 2 or 4 hours before drawing blood for testing. At the same time, chronic alcohol consumption can lead to other problems such as elevated triglyceride levels, elevated creatine kinase levels, elevated liver enzymes, and increased uric acid. As a result, blood tests can be affected, and the doctor could subsequently give a false diagnosis. Frequent alcohol consumption can also lead to mineral and vitamin deficiencies, particularly decreasing the B-complex vitamins. This potential B vitamin deficiency is a concerning problem in chronic alcohol abusers since the vitamins in the B complex are responsible for the proper functioning of the brain and nervous system. Patients are asked to cease alcohol consumption at least 24-48 hours before drawing blood for testing. This period should give the body enough time to process the alcohol consumed and prevent blood test levels from being affected. However, liver enzymes and triglycerides may not return to baseline in that short period. Another substance of concern is tobacco, which can also have a profound influence on blood test results. Those who smoke cigarettes have higher levels of nicotine in their bodies. As you probably know, nicotine is a drug which can increase cortisol levels and elevate concentrations of fatty acids in the blood. It may also increase hematocrit (red blood cell proportion, part of the CBC panel) since the body tries to produce more red blood cells to compensate for the lower oxygen level it is getting due to smoke in your lungs. As a result, blood tests can come up with confusing results. Whether cigarette smoking is acute or chronic, it's detrimental for one's health, and it can mess up with lab investigations. Cigarettes also contain thousands of toxins and chemicals which are harmful to the body, including arsenic and cadmium. These can increase the biomarkers of inflammation in the blood and show up in blood tests. 12. Exercise Physical exercise is one of the most important factors that influence blood test results. Whether you do resistance training, HIIT, yoga, or go for a bicycle ride, this activity could influence some of your blood tests. For example, after an intense session of exercise, the levels of creatine kinase (CK) in the body are increased. CK can remain elevated for up to a week, and this will be picked up on blood tests. Different types of exercises can also increase or decrease thyroid hormone blood tests. For example, doing anaerobic exercises can elevate the levels of thyroid stimulating hormone (TSH) in the body. At the same time, anaerobic exercises can also decrease FT3 levels. It is estimated that thyroid hormone levels can be altered for several hours or even several days, depending on the individual and his fitness level. Marathoners are also highly exposed to have altered hormonal levels before and after completing a run. For example, the levels of glucose, albumin, protein, and bilirubin were measured in professional marathoners 4 hours after a run. All these hormones were increased. Studies performed on professional football players who train regularly also reveal that frequent exercise can boost immune function. One study looked at the white blood cell count in 31 males who didn't do any exercise as well as 32 males who were playing football for a year. The white blood cell count was significantly higher in football players, and this leads to the conclusion that regular exercise can improve the immune response of a person. In another study performed on marathoners, it has been discovered that regular jogging for long periods can reduce the levels of C-reactive protein (CRP), which is a known marker of inflammation. However, excessive running can increase CRP and other inflammatory markers. When doctors perform an inflammation panel, they test the CRP levels primarily. They want to determine if the inflammation in the body is chronic or acute. Having lower CRP levels as marathoners do helps them avoid chronic inflammatory diseases. On the other hand, some marathoners also had high PSA levels after completing a marathon. PSA stands for prostate-specific antigen, and it's a marker of prostate disease. 2 out of 21 marathoners had increased PSA levels after running a marathon, which might state a problem with the prostate tissue. However, this can be a false diagnosis since vigorous exercise tends to increase PSA levels in certain people. That's why doctors recommend performing prostate tests twice if PSA levels are increased as a result of exercise. At the same time, one should wait at least 24 hours after exercise to do a prostate exam to get a more accurate diagnosis. Last but not least, weightlifting has been shown to result in profound increases in liver function tests in healthy men used to moderate physical activity, not including weightlifting. Liver function tests are significantly increased for at least 7 days after weightlifting. It is important to impose relevant restrictions on heavy muscular exercise prior to and during clinical studies.   Get Your Health Checked Up Today! It's amazing that we live in an era when we can order a blood test online and get the results back in a few days. The whole process is also confidential and super-affordable! You should take advantage of that and order your first blood test today. If you don't know what to start with, check out the popular tests on DiscountedLabs, and explore the multitude of blood panels available. These tests are inexpensive, and they'll help you get your health under control!

Testosterone replacement therapy is an important treatment option for men with low testosterone and symptomatic hypogonadism. Various formulations of exogenous (supplemental) testosterone replacement therapy exist, including oral, buccal, intramuscular, transdermal, subdermal, and nasal preparations. However, exogenous testosterone replacement therapy is a double-edged sword, posing risks to fertility due to negative feedback mechanisms on the hypothalamic-pituitary-gonadal (HPG) axis, which is the primary regulator of testosterone production and sperm production in men.  Testosterone replacement therapy (TRT) is one of the most effective ways to combat low testosterone levels, but you must understand the risks associated with the treatment. As with any hormone replacement therapy, there are a few downsides to receiving regular testosterone injections. But do these risks outweigh the benefits? That’s a decision you’ll have to make for yourself!   Testosterone replacement therapy- Target Blood Test Limits: To minimize TRT side effects, different medical guideline groups have created lab test value ranges and maximum acceptable targets . These values have been collected from three TRT guidelines and clinical practices around the United States: Hematocrit (percent of red blood cells in plasma) under 53 PSA (Prostatic specific antigen) under 3 (4 is max since doctors will not prescribe TRT at this number) Estradiol (sensitive) between 20-50 pg/mL. However, if you have high testosterone, estradiol will be "high" per Quest or Labcorp since 0.4% of total testosterone aromatizes to estradiol. Blood pressure under 135/85 Estimated Glomerular (eGFR) (kidney function) over 60 Liver enzymes not elevated over 20 percent of top value of reference range Total Testosterone over 450 ng/dL Free Testosterone equal or above 2 percent of total If donating blood to bring hematocrit down, ferritin should never under 30 ng/mL or micrograms/liter (this could lead to fatigue) Free T3 (if hypothyroid and on treatment) in the upper quartile of range. (depending on range it can be 3.7- 4.2 pg/mL) HDL over 40 mg/dL (higher TRT doses can lead to decreased HDL cholesterol) You can order these lab tests here: TRT Male Hormone/Wellness Follow-Up Panel PSA Lipid Panel Thyroid Panel    

Testosterone Injection: Subcutaneous vs. Intramuscular—Where to Inject Regardless of which TRT product you’ve been prescribed, a common question is where to inject testosterone. For decades, most men have used IM testosterone injections, primarily into the glutes, quads, or deltoids, using a 1 to 1.5-inch syringe. During the past five years, many men have also begun injecting testosterone subcutaneously (SubQ), a shallow injection into the fat layer on the abdominal or other areas—just under the skin but before reaching muscle. Many TRT patients find SubQ injections less bothersome than IM injections, as they require a smaller needle in both length and gauge. SubQ injections are also associated with less irritation for some men with IM injections. While some men may find IM injections to leave a minor soreness at the injected site, SubQ injections cause no noticeable pain or irritation. Understanding Testosterone Replacement Therapy Testosterone Replacement Therapy (TRT) is a medical treatment designed to help individuals with low testosterone levels, also known as hypogonadism. TRT aims to restore normal testosterone levels, alleviating symptoms such as low libido, fatigue, and decreased muscle mass. This form of hormone therapy can significantly improve the quality of life for those experiencing sexual dysfunction and other related issues. TRT can be administered through various methods, including intramuscular injections, subcutaneous injections, and topical gels. In this article, we will focus on testosterone injections, specifically intramuscular and subcutaneous injections, to provide a comprehensive understanding of these methods. Testosterone Injection Methods: Effects on Total Testosterone, Estradiol (E2), and PSA Testosterone Cypionate and Testosterone Enanthate are the two most commonly used forms of testosterone in men to treat hypogonadism (low testosterone). Both forms carry the same testosterone hormone; the ester is the only difference, which alters the hormone’s time release so that testosterone blood levels can remain up for a few days. These two testosterone compounds are identical in a testosterone replacement therapy (TRT) setting. Both forms are commonly used in hormone replacement therapy to treat hypogonadism in men. Where and How to Inject Testosterone? Regardless of which TRT product you’ve been prescribed, a common question is where to inject testosterone. For decades, most men have injected their testosterone intramuscularly (IM), primarily into the glutes, quads, or deltoids, using a 1- to 1.5-inch syringe. During the past five years, many men have also begun injecting testosterone subcutaneously (SubQ), a shallow injection into the fat layer on the abdominal or other areas—just under the skin but before reaching muscle. Many TRT patients find SubQ injections less bothersome than IM injections, as they require a smaller needle in both length and gauge. SubQ injections are also associated with less irritation for some men with IM injections. While some men may find IM injections to leave a minor soreness at the injected site, SubQ injections cause no noticeable pain or irritation. Many patients find it beneficial to inject weekly to maintain stable testosterone levels. Administering Testosterone Injections Safely Administering testosterone injections safely requires proper technique and precautions to ensure effectiveness and minimize risks. Before injecting, ensure the injection site is clean and free of any debris. Use a sterile needle and syringe, and follow the recommended dosage and injection frequency as prescribed by your healthcare provider. For intramuscular injections, use a longer needle (1 to 1.5 inches) and insert it at a 90-degree angle into the muscle, typically in the glutes, quads, or deltoids. For subcutaneous injections, use a shorter needle (0.5 to 1 inch) and insert it at a 45-degree angle into the fatty tissue, commonly in the abdominal area. Always dispose of used needles and syringes properly to prevent injury and contamination. By following these steps, you can administer testosterone injections safely and effectively. Choosing the Right Injection Site Choosing the right injection site is crucial for safe and effective testosterone injections. For intramuscular injections, common sites include the buttocks, thigh, and upper arm. These areas have larger muscle masses, which are ideal for proper absorption of the hormone. For subcutaneous injections, common sites include the abdomen, thigh, and buttock. When selecting an injection site, consider the following factors: Fat layer: Subcutaneous injections require a sufficient fat layer to ensure proper absorption. Muscle mass: Intramuscular injections require a larger muscle mass to ensure proper absorption. Nerve proximity: Avoid injecting near nerves to minimize the risk of nerve damage. Scarring: Rotate injection sites to minimize scarring and promote even absorption. By carefully choosing the injection site and rotating locations, you can enhance the effectiveness of your testosterone injections and reduce potential complications. What is the Best Way to Inject Testosterone? While subcutaneous testosterone injections are by far the most uncomplicated and most comfortable, the more critical question for any TRT patient is how effective this method is and how it affects the potential adverse side effects of TRT. Weekly injections are often recommended to maintain stable hormone levels and reduce side effects. A recent study from the Department of Urology at the University of California (UC) has provided us with such answers. The UC study attempted to answer four questions as they relate to IM vs. SubQ testosterone injections: Comparisons in: Total Testosterone Hematocrit (HCT) Estradiol (E2) Prostate-Specific Antigen (PSA) Two hundred thirty-two men took part in the UC study. Baseline levels were recorded for all men in the four measurement areas and then again at 6-12 weeks post-treatment. The results showed that men who underwent SubQ injections of testosterone resulted in a 14% greater increase in total testosterone levels than the testosterone level of IM patients. SubQ patients also had 41% lower hematocrit post-therapy than IM patients and 26.5% lower E2 levels. For both groups of men, there were no elevated levels of PSA. Additional Studies Comparing IM versus SubQ TRT While the UC study provides valuable data on four specific lab test values of concern and is one of the most recent studies on the topic of subcutaneous versus intramuscular testosterone injections, it is not the only information we have available. An additional Journal of Clinical Endocrinology study found that normal serum testosterone levels were maintained through SubQ injections. Most patients preferred the injection method due to less injection site pain. Similar results were found in a study headed by Dr. Al-Futais in a Canadian study that ran for one year in 2002. Similar results for subcutaneous testosterone injections have also been found in female-to-male (FTM) transgender people-based testosterone studies. The Journal of Clinical Endocrinology and Metabolism reported that FTM patients administering SubQ testosterone were found to easily reach stable and normal testosterone levels along with suitable E2 levels. The study concluded that SubQ testosterone injections are both safe and effective. These findings are particularly relevant for those undergoing gender-affirming hormone therapy, as they highlight the effectiveness and patient preference for SubQ injections. Although far less in-depth than we previously mentioned, a final study of note was published in the Journal of the Endocrine Society. Similar results to the reviews mentioned above were found, along with no significant changes between IM and SubQ patients relating to dihydrotestosterone (DHT). Interestingly, unlike the UC study, this study also measured no notable difference in E2 levels between the two categories. However, it must be noted that this particular study only included a single injection of testosterone undecanoate at 1000 mg. How to Inject Testosterone Using Subcutaneous Injections? If subcutaneous testosterone injections are right for you, you will merely need a small insulin syringe to administer the hormone. A 0.5-inch-long, 25-27 gauge needle in a 1 ml syringe will typically suffice. They also do not require aspiration, commonly used in old IM injection techniques. Unlike IM testosterone injections, SubQ injections do not require aspiration and use a smaller needle. Regardless, the aforementioned insulin needles and syringes are your best choice for comfort and ease of use. Due to the small needle size, you may find it slightly more difficult to draw the testosterone into the insulin syringe. But most men on TRT use 50-100 mg twice per week, which amounts to 0.25 to 0.5 ml of a 200 mg/ml testosterone cypionate or enanthate formulation commonly used in the United States. Those small volumes load up in just 1-2 minutes. Many TRT clinics prescribe protocols to patients to inject their testosterone subcutaneously once or twice weekly. This protocol effectively maintains stable testosterone levels with small, more frequent doses than the old dose of 200 mg once every two weeks. Two injections that split the weekly dose twice per week will suffice for most patients, such as a Monday and Thursday protocol. Is There Any Difference Between Testosterone Cypionate and Testosterone Enanthate? As mentioned early on, testosterone cypionate and testosterone enanthate are the two most commonly prescribed and lowest-cost testosterone esters worldwide. All four studies cited in our discussion were performed using Testosterone Enanthate, excluding the one using Undecanoate. However, using Testosterone Cypionate would have yielded similar, if not identical, results. Both versions of the testosterone hormone are just that, testosterone. Molecularly, there is no difference. It is merely the ester attached, and the carrier oil it may be mixed in is the only difference. Further, as the enanthate and cypionate esters have very similar time-release structures, total serum levels should be relatively the same with either compound, even if injected subcutaneously. Conclusion In conclusion, testosterone replacement therapy is a medical treatment designed to help individuals with low testosterone levels. Administering testosterone injections safely requires proper technique and precautions. Choosing the right injection site is crucial for safe and effective testosterone injections. By understanding the differences between intramuscular and subcutaneous injections, individuals can make informed decisions about their treatment options. Always consult with a healthcare professional before starting testosterone replacement therapy to ensure the best approach for your specific needs. References How to Inject Testosterone Intramuscularly, Shallow IM, or Subcutaneously? Comparison of Outcomes for Hypogonadal Men Treated with Intramuscular Testosterone Cypionate versus Subcutaneous Testosterone Enanthate SIU Academy. Choi E. 10/10/20; 309864; BSP-06.01 Subcutaneous Injection of Testosterone Is an Effective and Preferred Alternative to Intramuscular Injection: Demonstration in Female-to-Male Transgender Patients  The Journal of Clinical Endocrinology & Metabolism, Volume 102, Issue 7, 1 July 2017, Pages 2349–2355 Pharmacokinetics and Acceptability of Subcutaneous Injection of Testosterone Undecanoate J Endocr Soc. 2019 Aug 1; 3(8): 1531–1540.

It is suggested that you talk to your physician about the need for proper blood tests before and during testosterone. Read this first since it is the most common testosterone side effect: High hematocrit Problem Solution and Comments Acne/oily skin Caused by Dihydrotestosterone (DHT) effect on increased oil production · Accutane– a powerful prescription item - 40 mg/day for one week sometimes stops acne if started at the first sign or as directed by your doctor. Accutane is potentially highly liver toxic and can lower testosterone. Do not use unless as last resort. · Sporanox – Effective for some acne-like eruptions that are caused by fungi. Some doctors also prescribe antibiotics, like tetracycline, for acne with good results. . Minocycline . Shower with Nizoral shampoo· Anti-bacterial soaps - Use a scrubbing brush and wash twice a day, especially after sweating during a workout. · UV light or sunlight with moderation. . Zinc/copper supplements or zinc soaps may help some men with acne. . Other options: How to treat and prevent acne Hair loss Caused by DHT effect on hair follicles · Nizoral shampoo– Available by prescription and over-the-counter as a lower dose product. · Rogaine – Available over the counter · Propecia (finasteride) - Available by prescription. A few males experience decreased erections with finasteride. Do not use. Increased sex drive · A problem? Sex drive is part of quality-of-life. This is not necessarily a bad side effect. Enjoy it. Unresolved erectile function · ED Drugs– Available by prescription; enables robust erections. If you have sinus congestion or headaches/backaches take non-drowsy allergy medication and ibuprofen. ED drugs can be combined with alpha-blockers and/or nitric oxide precursor amino acids (arginine or citrulline) · Yohimbine (Yocon) - Available by prescription; increases sex organ sensitivity. Can increase heart rate and blood pressure · Muse - Available by prescription; pellet inserted into the urethra to produce an erection. Unpopular · Trimix – Available by prescription from compounding pharmacies. The best and cheapest formula for injection into the penis for lasting erections. · Caverject - Available by prescription. An injection into the penis that produces an erection that can last 1 to 2 hours. Be careful with injecting too much since it can produce dangerously ling erections that need to be treated in emergency rooms! Follow instructions from your urologist. · Papaverine – An older injectable medication, less expensive than Caverject. · Wellbutrin – Prescription at 300 to 450 mg/day; increases dopamine. · Human chorionic gonadotropin (HCG) – First dose is 2,000 IU, then 250-500 IU twice or three times a week. No protocol has been proven in controlled studies yet. Insomnia Usually, this is caused by dosages that are too high. Find the least amount that gives you a good result. · Sleeping medications – e.g. Ambien, Sonata, Lunesta, Restoril · Melatonin- 1 to 3 mg before bedtime. If you wake up groggy after 6 hours your dose should be lower. · Avoid working out too close to bedtime. · Limit caffeine, especially after 3 pm. · You may want to try a sleep formula with tryptophan, melatonin, and magnesium. Nutrients do not work as well as drugs, but they can help some people. Article: How to protect your circadian rhythm Sleep Apnea · Have your doctor prescribe a sleep study if you snore and wake up tired even after 7 hours of sleep. Some people may have to wear a C-PAP machine to breathe at night. Visit Home - SleepApnea.org for more information. There are also oral devices for those people who fail CPAP. Fatigue- When Testosterone Is Not Enough Testicular atrophy · Human Chorionic Gonadotropin (hCG)– One 2,000 unit injection per week for 2 weeks, followed by maintenance of 350-500 IU twice a week. For men who want to remain fertile while on TRT, 500 IU every other day has been studied. Watch this video on hCG and men Enhanced assertiveness or reactivity. · Make sure you are getting enough sleep. . Count until 10 and be aware of your interaction with others. · Decrease caffeine. · Meditation, mindfulness, yoga, breathe from your belly for a few minutes when overreacting. · The testosterone dosage may be too high. · Ask yourself: Do I need to always be right? . Vent extra energy at the gym, sex, and sharing with your buddies at www.excelmale.com High blood pressure: Can be caused by sodium retention, high hematocrit, being overweight, and other factors · Blood pressure medications - Elevated blood pressure may be transient or not. Try ACE or ARBs since they seem to have fewer sexual dysfunction related effects.  · Magnesium (600 mg/day); vitamin B6 (100 to 200 mg/day); may help reduce water retention. · Water - Drink extra water every day to help flush the kidneys. . Make sure you are doing cardio exercise at least 3 times a week for 30 min. Sweat and lower your salt intake since TRT increases sodium retention in some men. Gynecomastia- RARE in TRT (male breast development) Caused by overproduction of estrogen in the presence of low testosterone and high IGF-1 · Arimidex Inhibits estrogen production. Available by prescription. 0.5 mg/week max. Ensure that your estradiol is never under 20 pg/ml (by sensitive test) since it is needed for bone, skin, brain, lipids, libido, good lipids and hair health. Only 0.3-0.4% of testosterone is aromatized to estradiol. Current lab ranges were derived from men not on TRT. Most men on TRT do not need anastrozole. Be careful not to crash your estradiol. · Nolvadex (tamoxifen)– Competes with estrogen for receptors. Available by prescription, 10 to 20 mg/day. Use of Nolvadex during a steroid cycle may reduce the net anabolic effect, as it decreases the production of GH and IGF-1.  . Severe cases may require removal of the breast tissue by surgery. · DHT cream- Some people have obtained great results by rubbing a 10% DHT cream on their nipples. Not available in the US but some people order it online from Germany . Read about medications/foods to avoid if you have gynecomastia. . Those who do know to respond to the above, check other reasons Watch this video about estradiol in men Check your estradiol with the right sensitive test. To find out how long it takes testosterone replacement to potentially show benefits, read this article. For affordable blood tests in most cities in the U.S. (Prescription provided): DiscountedLabs.com We also highly recommend reading this and other articles from our friend Lee Myers from peaktestosterone.com : Testosterone Risks Metzger, DL, et al. Estrogen receptor blockade with tamoxifen diminishes growth hormone secretion in boys: evidence for a stimulatory role of endogenous estrogens during male adolescence. J Clin Endocrinol Metab (1994) 79(2):513-518. [ii] el-Sheikh, MM, et al. The effect of Permixon (saw palmetto) on androgen receptors. J Acta Obstet Gynecol Scand (1988) 67(5):397-399. [iii] Suzuki, K, et al. Endocrine environment of benign prostatic hyperplasia: prostate size and volume are correlated with serum estrogen concentration. Scand J Urol Nephrol (1995) 29:65-68. [iv] Gann, PH, et al. A prospective study of plasma hormone levels, nonhormonal factors, and development of benign prostatic hyperplasia. The Prostate (1995) 26:40-49.   Buy testosterone tests on DiscountedLabs.com

Tired of being tired?: Get these fatigue lab tests to find out why Getting fatigued is a normal part of life, but certain people feel profound tiredness all the times. Scientists agree that during the evening when it's time to go to bed, it is normal to feel tired and sleepy, but it's not normal if you feel that way in the morning after 8 hours of sleep. Chronic fatigue can be a real problem, and it can stay in the way of living a productive and happy life. Other symptoms may be present along with this problem, and if it persists for an extended period of time, the person may develop more serious health conditions. Table of Contents Tired of being tired?: Get these fatigue lab tests to find out why How do I know I'm chronically fatigued?   How does a complete fatigue panel help me? What are the advantages of getting a fatigue lab test panel? How does this panel diagnose chronic fatigue? Thyroid tests Free T4 Test – this type of test looks at a hormone in the body called thyroxine (T4). Thyroxine is then converted to T3, a hormone that regulates body temperature, helps in producing energy, and monitors heart rate. Total and Free Testosterone Tests Anemia Tests   Glucose Tests   The importance of insulin in the body High sugar levels in the blood can cause multiple health problems Adrenal Glands Tests Immune system tests Iron tests FAQ Conclusion How do I know I'm chronically fatigued? Again, being tired all the time and feeling like your battery is in "low-power" mode constantly goes beyond a usual headache, sore muscles, or a temporary lack of concentration. You might be chronically fatigued if: · You start to develop muscle and joint pains · You feel tired even after a good night's sleep · You lack energy, motivation, and you'd rather put your head on a pillow instead of doing something important · You have periodic mood swings · You have tried a plethora of energy drinks and drank multiple cups of coffee to no avail · You have mental fog most of the times · You feel exhausted, and even small physical efforts are difficult for you If you have one or more severe symptoms above, it is possible that you might be fatigued. This can happen because of a variety of reasons. For example, there might be hormonal deficiencies in your system which can render one unable to recover properly. The human body is extremely complex, and your fatigue problem might be difficult to spot at first. For example, some people might have low testosterone levels; others might encounter adrenal deficiencies or thyroid dysfunction. How does a complete fatigue panel help me? A complete fatigue panel is designed to analyze multiple hormones in the body to determine in which ones a person might be deficient. This can be done by drawing blood and saliva sample and sending them to a lab for complete analysis.   What are the advantages of getting a fatigue lab test panel? There are numerous benefits of getting a fatigue panel such as: · All-in-one testing procedure – the panel monitors the function of multiple organs and hormones such as the thyroid gland, adrenal glands, blood glucose, total and free testosterone, vitamin deficiencies, etc., so you don't have to do these tests separately · Order online and get results by email – once you get the panel, you go to a lab to offer a blood sample and get the results back by email, usually in just a few business days · Get a free consultation with a physician – not everyone is trained to analyze blood results, so once you get those, you will visit a local physician who will take a look at the results and provide professional guidance and counsel based on these results · 100% confidential and secure – your results are not shared with anyone and ordering a fatigue panel online is completely safe and secure   How does this panel diagnose chronic fatigue? As mentioned earlier, a complete fatigue panel runs multiple tests to determine vitamin or hormone deficiencies in one's body. Let's take a closer look at these tests and learn more about them.   Thyroid tests The thyroid gland is situated in the neck, responsible forregulating countless hormones and substances in the body. If it doesn't function correctly, the person in question might feel fatigued and lack motivation. Hypothyroidism happens when the thyroid gland gets "lazy," meaning it doesn't produce the required amount of hormones for the body to function correctly. Peoplewith hypothyroidism might feel tired most of the time, which is usually accompanied by other symptoms such as weight changes, loss of appetite, and poor concentration. In some cases, people might also experience other symptoms such as hair loss (particularly the eyebrows), brittle nails, and a great sensitivity to cold temperatures. The fatigue panel you order will analyze the function of the thyroid and run tests such as TSH, Free T3, and Free T4: Free T4 Test – this type of test looks at a hormone in the body called thyroxine (T4). Thyroxine is then converted to T3, a hormone that regulates body temperature, helps in producing energy, and monitors heart rate. Peoplewith hypothyroidism might experience a decreased production of thyroxine, leading to excessive fatigue, lack of motivation, and other symptoms. TSH test – TSH stands for thyroid stimulating hormone, a type of hormone produced by the pituitary gland. The fatigue panel looks at the levels of TSH in your bloodstream to determine if you have too much or too little TSH. This hormone is essential because as its name implies, it stimulates the thyroid gland to produce T4 and T3 hormones. If the TSH levels are too high, the thyroid gland might work overtime, leading to thyroid dysfunction and fatigue. Free T3 Test – We talked about the T3 hormone earlier in the "Free T4 Test," and learned that the T3 gets converted from T4. This hormone (T3) is also responsible for regulating the heart rate, body temperature, and other essential body functions. If the levels of unbound triiodothyronine (T3) are too low, this might result in excessive fatigue, which can last for weeks and even months. It is essential to mention here that a high-quality fatigue panel looks at the free levels of T3 in the body, not only at the total T3 levels because these are the most responsible for regulating energy and causing fatigue. Total and Free Testosterone Tests Testosterone is one of the most essential hormones in the body for men AND women. Today, it is a well-known fact that low testosterone levels are responsible for the lack of motivation, low energy, and even mild depression in some cases. Testosterone is available in 2 ways – free and bound to proteins. A high-quality fatigue panel looks at the total testosterone levels and free testosterone levels (unbound to proteins) to determine if this is indeed the leading cause of excessive tiredness in men and women. The total testosterone test measures the whole spectrum of testosterone in one's body. This should be between 300 and 900 nanograms per deciliter of blood for men, but this depends on lifestyle, age, body composition, and other factors. When the total testosterone levels drop below 350 ng/dl, a condition known as hypogonadism develops. This diagnosis can be a severe cause of excessive fatigue and other symptoms and body changes such as lack of concentration and male breast development (gynecomastia). The free testosterone test looks specifically at unbound testosterone levels. It is important to measure those in particular because a low amount of them can account for excessive fatigue in men and women of all ages.   Anemia Tests Anemia is a severe problem which can become very dangerous for one's health if left untreated. As you probably already know, red blood cells are responsible for transporting oxygen and nutrients to cells, tissues, and organs throughout the body. Anemic people usually have too few red blood cells in the bloodstream. Too few red blood cells can cause various symptoms such as excessive tiredness, dizziness, irregular heartbeats, etc. The fatigue panel runs various tests to determine the level of hemoglobin in the body (a protein responsible for carrying oxygen) and analyze hematocrit values (the volume of red blood cells in the bloodstream). The hematocrit tests look at the percentage of red cells in the bloodstream. A small rate might be indicative of anemia as well as chronic fatigue. The hemoglobin tests measure the level of hemoglobin in the body. Again, if this protein is in small quantities, one can develop anemia. The Mean Corpuscular Volume (MCV) tests look at the size of the red blood cells. This is important because if the size of these cells is too small, this might result in iron deficiency. If the cells are too large, this might be linked to vitamin B6 or folic acid deficiency. The Red Cell Distribution Width (RDW) values are also measured in conjunction with the MCV to determine the potential cause of anemia. Glucose Tests Just as cars need to burn fuel to move from one place to the other, your body also requires an adequate fuel supply to function correctly. If vehicles have gasoline, we humans have glucose (or sugar). Normal blood sugar levels help one have sufficient energy to get through the day. However, too much or too little blood sugar levels can lead to multiple severe health conditions and excessive fatigue. When the body detects a high amount of sugar in the bloodstream (particularly after eating meals full of carbs and fats, which are metabolized into glucose in the body), it will signal the pancreas to produce a hormone called insulin. The importance of insulin in the body Insulin acts as a locksmith that opens up cells, so they can absorb the excess glucose in the bloodstream and produce energy. When the blood sugar levels return to normal, the pancreas stops producing insulin, and the cycle repeats. However, when too much glucose is detected in the bloodstream regularly, the pancreas is forced to produce higher amounts of insulin which might then drop the sugar levels too low. As a result, your cells and organs won't have as much fuel at their disposal, and you always feel tired. Furthermore, when there is an excessive amount of sugar in the blood for several years in a row, the cells in the body start to develop insulin resistance, meaning that they won't "open up" as efficiently as before to absorb glucose and produce energy. This can lead to diabetes which is a severe medical condition.   High sugar levels in the blood can cause multiple health problems High amounts of glucose can also lead to other issues such as slow circulation, higher risk of inflammation in the body, less oxygen transported to cells, organs, etc. People who experience these symptoms are fatigued most of the time, despite having regular sleep schedules. Even those who have high blood sugar levels but do not have diabetes can still feel tired most of the time, compared with people with normal glucose levels. A fatigue panel is designed to test glucose levels and determines if one is predisposed to diabetes type I and II. Such tests also measure the average glycated hemoglobin levels (A1c), which are sugar-coated oxygen-carrying red blood cell proteins. A high level of these cells can indicate a predisposition to diabetes at some point in the future and can be linked to chronic fatigue. Note that insulin testing requires 12-hour fasting for accurate results.   Adrenal Glands Tests The adrenal glands are situated just on top of your kidneys and generate multiple important hormones such as epinephrine (adrenaline) and cortisol. Think of them as responsible with the "fight or flight" response when you're stressed out, scared, or excited. These glands are essential because if they don't function correctly, one can develop chronic fatigue and mild signs of depression. Studies show that approximately 40% of people over 60 have to deal with constant tiredness associated with reduced adrenal function. We all live stressful lives and have to juggle a thousand daily problems and responsibilities. This makes the adrenal glands pump a lot of cortisol and adrenaline into the body. Too many hormones can make someone feel very stressed, mildly depressed, and fatigued. Poor sleep quality can also worsen the problem because the adrenal glands tend to recover when the body is at rest. Most people don't get enough sleep during the night, so these glands don't get a chance to rejuvenate properly. Add periodic stimulants to the equation (alcohol and drugs), and the load on the adrenal glands can quickly become overwhelming. Adrenal problems don't only translate into constant fatigue. Dizziness, poor concentration, anxiety and panic attacks, etc also accompany them. A complete fatigue panel looks at the hormones produced by the adrenal glands and determines if they are in sufficient quantities. For example: The DHEA test looks at the levels of DHEA-S in the body. This is an androgen hormone, and if it is in excessively high quantities, the person in question might suffer from adrenal hyperplasia. Similarly, if the levels of DHEA-S are insufficient, this can lead to chronic fatigue. The salivary cortisol test is also essential in determining the differences in cortisol levels at different moments of the day. Patients will be asked to collect four saliva samples during the day, and this will indicate whether the adrenal glands function correctly or they produce too much cortisol regularly.   Immune system tests As you probably already know, the immune system is responsible for neutralizing viruses and bacteria which get in the body so you don't get sick all the time. It relies on a series of cells, such as the T cells and other hormones, to identify viruses and eliminate them before they get a chance to multiply. An immune system that functions properly requires energy.Suppose there is too much inflammation in the body (as a result of injury, being exposed to a lot of viruses and toxins, etc.). In that case, this system will work overtime to protect your health, and it will consume vast amounts of energy, leaving you tired and in a bad mood. A complete fatigue panel includes tests that measure the number of white cells in the bloodstream. These cells are responsible for neutralizing viruses and bacteria as well. In some rare cases, the bone marrow might not produce sufficient white cells, which can signify a more severe problem.   Iron tests Iron is an essential element in the body, as it produces red blood cells that help carry oxygen to organs and tissues. Anemia, which is characterized by exhaustion, wooziness, and a general feeling of weakness, can result from not having enough iron in one's body. A fatigue panel looks at different hormones in the body which are responsible for metabolizing and storing iron. For example: The ferritin test looks at the ferritin levels in the bloodstream. This protein is responsible for storing iron, and if its levels are insufficient, one can develop anemia, which leads to excessive tiredness. One reason ferritin levels might be low is that one donates too much blood each year. Studies show that donating blood more than twice a year can deplete ferritin levels, leading to anemia. The TIBC test (total iron binding capacity) looks at the absolute levels of iron available in the bloodstream. If this value is too high, then the amounts of iron in the body are insufficient, which can cause excessive fatigue. FAQ 1. Do I need to fast before getting tested? Fasting requirements vary by test. Most tests require 8-12 hours of fasting, with some specific tests like insulin requiring 12 hours of fasting. Iron tests should be collected in the morning from patients in a fasting state. Also, biotin supplementation should be stopped 72 hours before being tested. 2. How quickly are the results delivered? You will usually get the results by email in a few business days. 3. What specimens are submitted for testing? Fatigue panels require patients to submit a blood specimen and, in some cases, a saliva specimen for testing. The instructions on managing and properly collecting these samples are provided within the package, so you will know precisely what to do. 4. What should I do after I get the results? Your healthcare provider will interpret your results and, if necessary, will suggest effective treatment options. For example, if you have iron deficiency and this is the leading cause of your fatigue, you'll be guided to supplement with iron for some time. Similarly, suppose low testosterone or thyroid hormone blood levels cause your fatigue. In that case, you'll be advised to explore solutions such as Testosterone Replacement Therapy (TRT) or thyroid hormone replacement to help deal with your fatigue problem. 5. Is this test safe? Yes! The submission of samples and results analysis is entirely confidential, and you'll be drawing blood in a medical setting under specialized supervision.   Conclusion Diagnosing chronic fatigue is not easy, but you're one step closer to feeling better by ordering a comprehensive fatigue panel. Order the complete fatigue panel today from Discounted Labs, and you can drastically improve the quality of your life!   BUY THE COMPREHENSIVE FATIGUE BLOOD TEST PANEL HERE