Page 4 - Testosterone Blood Tests

Did you know that testosterone deficiency has a prevalence of up to 40% in adult males in the United States? A man is deficient in testosterone when his T levels fall below 300 ng/dL of blood. Although this is slightly worrisome news, there are multiple testosterone replacement options you can take advantage of these days. This article focuses on some of the most important testosterone products in 2023. Keep reading to learn key facts, statistics, price ranges, and optimal dosages related to your favorite testosterone products. Top Testosterone Replacement Therapy Options You Have in 2023 Fortunately, there are many ways you can get more testosterone into your system. There are patches, pellets, gels, injections, and even oral capsules that you can take once or twice a day. If you don't really fancy having to inject testosterone once a week, you can take capsules orally and reap all the benefits of testosterone replacement therapy. The following is a quick list of testosterone replacement products you can take advantage of to increase blood T levels. Administration of T products should only be done according to the strict guidance of your TRT doctor. FDA-Approved Testosterone Brands Androderm: Androderm is a transdermal testosterone patch that delivers testosterone through the skin. It is applied daily to maintain stable testosterone levels in men with low testosterone due to certain medical conditions[1]. This option is no longer used by most doctors since its efficacy was not good and it caused skin irritation. AndroGel: AndroGel is a topical testosterone gel that is applied directly to the skin, typically on the upper arms, shoulders, or abdomen. It is designed for daily use to help maintain consistent testosterone levels for men with low testosterone[1]. It comes in two concentrations. Fortesta: Fortesta is another topical testosterone gel applied to the skin, usually on the front and inner thighs. It is used for testosterone replacement therapy in males with low testosterone levels[2]. Testim: Testim is a testosterone gel applied daily to the skin, typically on the upper arms and shoulders, to help maintain consistent testosterone levels in men with low testosterone due to certain medical conditions[1]. Depo-Testosterone: Depo-Testosterone is an injectable form of testosterone prescribed for men with low testosterone levels. It is administered by a healthcare professional at regular intervals, typically every two to four weeks[2]. Testopel is a subcutaneous testosterone pellet that a medical professional implants under the skin. The pellets release testosterone over an extended period, typically three to six months[2]. Aveed: Aveed is an injectable testosterone undecanoate solution designed for long-acting testosterone replacement therapy. It is administered by a healthcare professional at regular intervals, typically every 10 weeks after an initial loading phase[2]. Natesto: Natesto is a testosterone nasal gel that is applied inside the nostrils for testosterone replacement therapy. It is used to treat men with low testosterone levels due to certain medical conditions[2]. Vogelxo: Vogelxo is a topical testosterone gel applied daily to the skin, usually on the upper arms, shoulders, or abdomen. It is used for testosterone replacement therapy in males with low testosterone levels[2]. Xyosted: Xyosted is a subcutaneous testosterone enanthate autoinjector for weekly self-administration. It is prescribed for men with low testosterone levels due to certain medical conditions[2]. Jatenzo: Jatenzo is an oral testosterone undecanoate capsule that the FDA has approved to treat certain types of hypogonadism in men. It is taken orally to help maintain stable testosterone levels in men with low testosterone [2] Testosterone Treatment Prices and Dosing Androgel 1% Price for a 30-day supply (in USD): 55-85 for the generic pump, 90-190 for 50 mg generic packets; also, around 650 USD for Brand 50 mg packets Delivery mode: pump and/or packet Dosage: 25 mg/2.5 g or 50mg/5g Where to apply shoulders, upper arms or on the abdomen Starting dosage: 50 mg daily dose early in the morning When to measure: in the morning before applying the gel Androgel 1.62% Price for a 30-day supply (in USD): 40-140 for the generic pump, 620-640 for Brand pump Delivery mode: pump and/or packet Dosage: 20.25 mg or 40.5 mg Where to apply shoulders or upper arms Starting dosage: 40.5 mg daily dose early in the morning When to measure in the morning before applying the gel Testim 1% Price for a 30-day supply (in USD): around 600-610 for packets Delivery mode: pump Dosage: 20.25 mg per actuation Where to apply shoulders or upper arms Starting dosage: one pump on each shoulder for a total of 40.5 mg early in the morning, it can also be applied on inner thighs When to measure: in the morning before applying the gel Fortesta 2% Delivery mode: pump Dosage: 50 mg or 100 mg Where to apply shoulders or upper arms Starting dosage: two pumps daily in the morning on each thigh When to measure: 2 hours after applying a dose Vogelxo Price for a 30-day supply (in USD): 100-350 for 1% pump, 120-350 for generic packets Delivery mode: shoulders or upper arms Dosage: 50 mg from 4 actuations of 12.5 mg testosterone Where to apply shoulders or upper arms Starting dosage: 50 mg daily in the morning When to measure before applying a dose Androderm Delivery mode: patch applied at night after 10 PM Dosage: 2 mg per day, 2.5 mg per day, 4 mg per day or 5 mg per day Where to apply: abdomen, upper arms, thighs, back Starting dosage: 4 mg per day When to measure: 12 hours after skin application Natesto Price for a 30-day supply (in USD): 195-300 for 5.5 mg/actuation Delivery mode: intranasal pump Dosage: 5.5 mg per pump actuation Where to apply intranasal Starting dosage: 11 mg (2 actuations) 3 times per day at an interval of 6-8 hours When to measure: 2 hours after nasal application Jatenzo Price for a 30-day supply (in USD): around 950 for 237 mg BID pill Delivery mode: oral capsule Dosage: 158 mg, 198 mg, or 237 mg Where to apply oral Starting dosage: 237 mg capsule twice a day (one in the morning, one in the evening) When to measure: 6 hours after the morning dose Testopel Delivery mode: pellet Dosage: 75 mg per pellet Where to apply can be inserted under the skin, in the fat of the buttocks, thigh or lower abdominal wall Starting dosage: 150-450 mg every 3 to 6 months When to measure: at the end of the dosing interval Aveed Delivery mode: injectable solution Dosage: 100 mg/10 ml vial, 200 mg/1-10 ml vial or 750 mg/3 ml vial Where to apply: intramuscular in the glute or thigh muscles Starting dosage: 750 mg (3 ml) in the beginning, then after 4 weeks then after every 10 weeks; 75-100 mg/week also or 150-200 mg every 2 weeks When to measure: injections are administered every 10 weeks and T measurement should be done somewhere in between injections (after 5 weeks or so since the last one) Xyosted Price for a 30-day supply (in USD): 455-575 for 50 mg, 75 mg and 100 mg injections Delivery mode: the solution is placed in the autoinjector Dosage: 50 mg, 75 mg or 100 mg respectively Where to apply: in the abdominal region under the skin Starting dosage: 75 mg applied under the skin once a week When to measure T levels: trough concentrations are measured 7 days after the most recent dose and only after 6 weeks since the beginning of treatment. These are just a few popular testosterone replacement products available in the US. Keep in mind that you can also procure testosterone enanthate in 5 ml (1000mgs) vials from certain pharmacies. This option usually costs less than $30 for a 30-day supply and the testosterone can be injected by each patient without requiring a doctor's visit. Similarly, TRT patients can also choose to use generic testosterone cypionate or enanthate as 400 mg to 800 mg per month that can be injected into muscle (deep IM or shallow IM) or under belly fat (subcutaneous) . The price for a 30-day supply starts at around $30 and it can go up to $85 . (Source: GoodRx). Other affordable sources of testosterone treatments can be purchased from compounding pharmacies like Empower in Houston. Check Out How AUA and ES Guidelines Differ on Testosterone Ranges AUA stands for American Urology Association and ES stands for Endocrine Society. They provide detailed insights and standards on how to interpret hormone levels and blood test results. In some cases, these committees can give different interpretations when it comes to testosterone levels. AUA Guidelines: What is a Normal Testosterone Range and Follow Up? According to the American Urology Association (AUA), you should measure your testosterone levels in the morning in a fasted state to get accurate results. The normal range is between 450 ng/dL and 600 ng/dL of blood. If your levels fall below 300 ng/dL of blood, you are considered to be deficient in testosterone. If you start testosterone replacement therapy, your first evaluation should be between 2 and 4 weeks after beginning treatment. You will also have to attend follow-up visits 6 to 12 months after starting TRT. ES Guidelines: What is a Normal Testosterone Range and Follow Up? On the other hand, the Endocrine Society (ES) gives slightly different reference ranges. For example, the normal testosterone range is between 264 ng/dL and 916 ng/dL of blood. The best moment to test your T levels is early in the morning in a fasted state. Testosterone deficiency is confirmed if your T levels fall below 264 ng/dL of blood.  TRT follow up visits should be done after 2-3 months and after 6 to 12 months from the start of your testosterone replacement protocol. How to Get Your Own Affordable Testosterone Test Remember that now it's easier than ever to check your testosterone levels and see if you are a suitable candidate for testosterone replacement therapy. If your T levels fall below 350 ng/dL and have low testosterone symptoms then you should talk with a TRT doctor and see what testosterone replacement options you have. Check your testosterone levels quickly and confidentially by ordering a total and free testosterone test from DiscountedLabs today. Key Terminology and Facts About Testosterone It's important to also have some basic understanding of how testosterone works in the body, so you can make better decisions when talking with your TRT doctor. For instance, the Leydig cells in your testicles produce more than 95% of your testosterone. Testosterone daily production ranges from 3 mg to 11 mg and it peaks early in the morning. Healthy adult males have the highest concentration of testosterone early in the morning and it gradually drops throughout the day. That's why the best time to measure your T levels is early in the morning to get accurate results. Natural Testosterone Short half-life - your testosterone has a half-life between 10 and 100 minutes. It peaks once every 3 hours as the luteinizing hormone stimulates the Leydig cells to produce more testosterone. With the passing of time, these cells become less sensitive to LH and they produce increasingly low T levels. It's estimated that males lose about 1% of their testosterone production every year after the age of 30. 2 percent is free; about 2% of your total testosterone level is free. This means that it circulates freely through the bloodstream and it can bind to other organs or tissues. 70% of your testosterone is bound to sex hormone-binding globulin and nearly 30% is bound to albumin. Testosterone metabolism - fractions of your testosterone are converted into other hormones and substances. For example, from 5% to 8% of your testosterone is converted into dihydrotestosterone (DHT). This hormone is responsible for prostate maturation and the growth of the body, as well as facial and pubic hair. About 0.3%–0.5% of your testosterone is also converted into estradiol by the aromatase enzyme. Some of the main roles of estradiol in men are involved with libido and bone health. Trough concentration - this refers to the lowest  concentration of a drug in the bloodstream immediately before injecting or administering another dose. It's highly recommended to measure your testosterone levels at trough concentration because this will produce the most accurate results. Based on these results, TRT doctors can make more accurate adjustments to your protocol. Find Out More About Testosterone Products! This is just a brief overview of some of the most popular testosterone products in the US, but there's plenty more high-quality information out there. Visit Excelmale.com and learn everything you need to know about testosterone, TRT, how to interpret your blood test data, and how to tweak your protocol for optimal results. Also, you can download the Testosterone Replacement Options paper from this link.   References: [1] "FDA-approved testosterone formulations include the topical gel, transdermal patch, buccal system (applied to upper gum or inner cheek), and injection. The manufacturers of two prescription..." URL: https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/testosterone-information [2] "by Drugs.com Brand names of testosterone include Androderm, AndroGel, Fortesta, Testim, Depo-Testosterone, Testopel, Aveed, Natesto, Vogelxo, Xyosted, Jatenzo, Tlando, and Kyzatrex. Testosterone is an androgen indicated for testosterone replacement therapy in males." URL: https://www.drugs.com/medical-answers/brands-testosterone-3510863/   Recommended Sources: Testosterone Replacement Therapy Options | Excel Male TRT Forum Testosterone Replacement Products in the U.S.: Video Review by Nelson Vergel - ExcelMale Testosterone Test Near Me: Your Complete Guide Testosterone levels show steady decrease among young US men        

  In a recent study, researchers explored whether consuming glucose (a type of sugar) affects testosterone levels in men who are receiving testosterone therapy, which is a common treatment for men with low testosterone levels. Men's testosterone levels can vary depending on a variety of factors, including their diet. Testosterone is a crucial hormone that affects many bodily processes. Is Fasting for Testosterone Test Required in Men on TRT? Study Overview and Objectives According to the findings of a recent study, scientists looked at the potential connection between male patients undergoing testosterone therapy—a typical treatment for low testosterone levels—and their intake of glucose, a type of sugar, and their testosterone levels. The aim of the research was to determine whether consuming glucose had an effect on testosterone levels. A man's diet is one of several factors that could influence his testosterone levels. A variety of other factors may also have an impact on a man's testosterone levels. Testosterone is involved in a large number of bodily processes. It is an essential hormone. Methodology and Participant Demographics An explanation of the methodology and pertinent information: Men with low testosterone and type 2 diabetes—a condition in which the body struggles to regulate blood sugar levels—made up the bulk of participants. In this study that examined the effects of glucose, fourteen individuals drank a glucose drink with 75 grams of sugar. The following two hours were spent doing the experiment and measuring the subjects' testosterone levels. It was done once, before the men started testosterone replacement therapy (TRT), and once more after the men had TRT injections for 23 weeks. The first round of this test was done before the guys started taking testosterone treatment. Initial Findings An Overview of the Most Significant Results: Before beginning testosterone therapy, the men reported that their testosterone levels had dramatically dropped after a carbohydrate meal; nevertheless, these levels had returned to normal in less than two hours. This took place before the testosterone treatment began. This was prior to the men beginning to raise their testosterone levels with TRT. It's an intriguing phenomenon because during 23 weeks of testosterone therapy, the body's levels of testosterone were unaffected by glucose ingestion. Participant Characteristics Age and Average Body Mass Index: The average body mass index (BMI), which calculates body fat based on height and weight, for the individuals was 38 kg/m2, indicating obesity. The average age of the individuals was 53. Conclusion and Implications  The results of the study show that men on testosterone therapy do not temporarily lower their testosterone levels when they consume glucose in the same way as men not receiving treatment. This finding is important for the creation of medical guidelines because it suggests that, although testosterone levels should be measured during fasting in order to diagnose low testosterone in men not on TRT, these levels may not need to be tracked in the same manner once testosterone therapy has begun. This is an important finding since it suggests that the baseline testosterone levels should be evaluated while fasting, but the follow up testosterone blood tests do not require fasting once men are on TRT. Clinical Recommendations Specific Guidance on Implementing Clinical Practice: The findings suggest that endocrinology societies should update their guidelines to include the possibility that fasting testosterone levels may not be necessary for monitoring the effectiveness of testosterone therapy in men who are already receiving treatment, even though they are necessary for diagnosing low testosterone. There would be an advantage to the field from this advancement. Study Significance This paper offers important insights into how dietary glucose impacts hormone levels in males with diabetes getting testosterone therapy, which helps to clarify the complexity of treating endocrine illnesses. The factors that specifically influence hormone levels are the subject of the investigation.   Reference: 1.Dhindsa S, Ghanim H, McPhaul MJ, Ghoshal AK, Dandona P. Glucose Ingestion does not lower Testosterone concentrations in men on Testosterone Therapy. Journal of Investigative Medicine. 2024;0(ja). doi:10.1177/10815589241252510

Tired of being tired?: Get these fatigue lab tests to find out why Getting fatigued is a normal part of life, but certain people feel profound tiredness all the times. Scientists agree that during the evening when it’s time to go to bed, it is normal to feel tired and sleepy, but it’s not normal if you feel that way in the morning after 8 hours of sleep. Chronic fatigue can be a real problem, and it can stay in the way of living a productive and happy life. Other symptoms may be present along with this problem, and if it persists for an extended period of time, the person may develop more serious health conditions. Table of Contents Tired of being tired?: Get these fatigue lab tests to find out why How do I know I’m chronically fatigued?   How does a complete fatigue panel help me? What are the advantages of getting a fatigue lab test panel? How does this panel diagnose chronic fatigue? Thyroid tests Free T4 Test – this type of test looks at a hormone in the body called thyroxine (T4). Thyroxine is then converted to T3, a hormone that regulates body temperature, helps in producing energy, and monitors heart rate. Total and Free Testosterone Tests Anemia Tests   Glucose Tests   The importance of insulin in the body High sugar levels in the blood can cause multiple health problems Adrenal Glands Tests Immune system tests Iron tests FAQ Conclusion How do I know I’m chronically fatigued? Again, being tired all the time and feeling like your battery is in “low-power” mode constantly goes beyond a usual headache, sore muscles, or a temporary lack of concentration. You might be chronically fatigued if: · You start to develop muscle and joint pains · You feel tired even after a good night’s sleep · You lack energy, motivation, and you’d rather put your head on a pillow instead of doing something important · You have periodic mood swings · You have tried a plethora of energy drinks and drank multiple cups of coffee to no avail · You have mental fog most of the times · You feel exhausted, and even small physical efforts are difficult for you If you have one or more severe symptoms above, it is possible that you might be fatigued. This can happen because of a variety of reasons. For example, there might be hormonal deficiencies in your system which can render one unable to recover properly. The human body is extremely complex, and your fatigue problem might be difficult to spot at first. For example, some people might have low testosterone levels; others might encounter adrenal deficiencies or thyroid dysfunction. How does a complete fatigue panel help me? A complete fatigue panel is designed to analyze multiple hormones in the body to determine in which ones a person might be deficient. This can be done by drawing blood and saliva sample and sending them to a lab for complete analysis.   What are the advantages of getting a fatigue lab test panel? There are numerous benefits of getting a fatigue panel such as: · All-in-one testing procedure – the panel monitors the function of multiple organs and hormones such as the thyroid gland, adrenal glands, blood glucose, total and free testosterone, vitamin deficiencies, etc., so you don’t have to do these tests separately · Order online and get results by email – once you get the panel, you go to a lab to offer a blood sample and get the results back by email, usually in just a few business days · Get a free consultation with a physician – not everyone is trained to analyze blood results, so once you get those, you will visit a local physician who will take a look at the results and provide professional guidance and counsel based on these results · 100% confidential and secure – your results are not shared with anyone and ordering a fatigue panel online is completely safe and secure   How does this panel diagnose chronic fatigue? As mentioned earlier, a complete fatigue panel runs multiple tests to determine vitamin or hormone deficiencies in one’s body. Let’s take a closer look at these tests and learn more about them.   Thyroid tests The thyroid gland is situated in the neck, responsible forregulating countless hormones and substances in the body. If it doesn’t function correctly, the person in question might feel fatigued and lack motivation. Hypothyroidism happens when the thyroid gland gets “lazy,” meaning it doesn’t produce the required amount of hormones for the body to function correctly. Peoplewith hypothyroidism might feel tired most of the time, which is usually accompanied by other symptoms such as weight changes, loss of appetite, and poor concentration. In some cases, people might also experience other symptoms such as hair loss (particularly the eyebrows), brittle nails, and a great sensitivity to cold temperatures. The fatigue panel you order will analyze the function of the thyroid and run tests such as TSH, Free T3, and Free T4: Free T4 Test – this type of test looks at a hormone in the body called thyroxine (T4). Thyroxine is then converted to T3, a hormone that regulates body temperature, helps in producing energy, and monitors heart rate. Peoplewith hypothyroidism might experience a decreased production of thyroxine, leading to excessive fatigue, lack of motivation, and other symptoms. TSH test – TSH stands for thyroid stimulating hormone, a type of hormone produced by the pituitary gland. The fatigue panel looks at the levels of TSH in your bloodstream to determine if you have too much or too little TSH. This hormone is essential because as its name implies, it stimulates the thyroid gland to produce T4 and T3 hormones. If the TSH levels are too high, the thyroid gland might work overtime, leading to thyroid dysfunction and fatigue. Free T3 Test – We talked about the T3 hormone earlier in the “Free T4 Test,” and learned that the T3 gets converted from T4. This hormone (T3) is also responsible for regulating the heart rate, body temperature, and other essential body functions. If the levels of unbound triiodothyronine (T3) are too low, this might result in excessive fatigue, which can last for weeks and even months. It is essential to mention here that a high-quality fatigue panel looks at the free levels of T3 in the body, not only at the total T3 levels because these are the most responsible for regulating energy and causing fatigue. Total and Free Testosterone Tests Testosterone is one of the most essential hormones in the body for men AND women. Today, it is a well-known fact that low testosterone levels are responsible for the lack of motivation, low energy, and even mild depression in some cases. Testosterone is available in 2 ways – free and bound to proteins. A high-quality fatigue panel looks at the total testosterone levels and free testosterone levels (unbound to proteins) to determine if this is indeed the leading cause of excessive tiredness in men and women. The total testosterone test measures the whole spectrum of testosterone in one’s body. This should be between 300 and 900 nanograms per deciliter of blood for men, but this depends on lifestyle, age, body composition, and other factors. When the total testosterone levels drop below 350 ng/dl, a condition known as hypogonadism develops. This diagnosis can be a severe cause of excessive fatigue and other symptoms and body changes such as lack of concentration and male breast development (gynecomastia). The free testosterone test looks specifically at unbound testosterone levels. It is important to measure those in particular because a low amount of them can account for excessive fatigue in men and women of all ages.   Anemia Tests Anemia is a severe problem which can become very dangerous for one's health if left untreated. As you probably already know, red blood cells are responsible for transporting oxygen and nutrients to cells, tissues, and organs throughout the body. Anemic people usually have too few red blood cells in the bloodstream. Too few red blood cells can cause various symptoms such as excessive tiredness, dizziness, irregular heartbeats, etc. The fatigue panel runs various tests to determine the level of hemoglobin in the body (a protein responsible for carrying oxygen) and analyze hematocrit values (the volume of red blood cells in the bloodstream). The hematocrit tests look at the percentage of red cells in the bloodstream. A small rate might be indicative of anemia as well as chronic fatigue. The hemoglobin tests measure the level of hemoglobin in the body. Again, if this protein is in small quantities, one can develop anemia. The Mean Corpuscular Volume (MCV) tests look at the size of the red blood cells. This is important because if the size of these cells is too small, this might result in iron deficiency. If the cells are too large, this might be linked to vitamin B6 or folic acid deficiency. The Red Cell Distribution Width (RDW) values are also measured in conjunction with the MCV to determine the potential cause of anemia. Glucose Tests Just as cars need to burn fuel to move from one place to the other, your body also requires an adequate fuel supply to function correctly. If vehicles have gasoline, we humans have glucose (or sugar). Normal blood sugar levels help one have sufficient energy to get through the day. However, too much or too little blood sugar levels can lead to multiple severe health conditions and excessive fatigue. When the body detects a high amount of sugar in the bloodstream (particularly after eating meals full of carbs and fats, which are metabolized into glucose in the body), it will signal the pancreas to produce a hormone called insulin. The importance of insulin in the body Insulin acts as a locksmith that opens up cells, so they can absorb the excess glucose in the bloodstream and produce energy. When the blood sugar levels return to normal, the pancreas stops producing insulin, and the cycle repeats. However, when too much glucose is detected in the bloodstream regularly, the pancreas is forced to produce higher amounts of insulin which might then drop the sugar levels too low. As a result, your cells and organs won’t have as much fuel at their disposal, and you always feel tired. Furthermore, when there is an excessive amount of sugar in the blood for several years in a row, the cells in the body start to develop insulin resistance, meaning that they won’t “open up” as efficiently as before to absorb glucose and produce energy. This can lead to diabetes which is a severe medical condition.   High sugar levels in the blood can cause multiple health problems High amounts of glucose can also lead to other issues such as slow circulation, higher risk of inflammation in the body, less oxygen transported to cells, organs, etc. People who experience these symptoms are fatigued most of the time, despite having regular sleep schedules. Even those who have high blood sugar levels but do not have diabetes can still feel tired most of the time, compared with people with normal glucose levels. A fatigue panel is designed to test glucose levels and determines if one is predisposed to diabetes type I and II. Such tests also measure the average glycated hemoglobin levels (A1c), which are sugar-coated oxygen-carrying red blood cell proteins. A high level of these cells can indicate a predisposition to diabetes at some point in the future and can be linked to chronic fatigue.   Adrenal Glands Tests The adrenal glands are situated just on top of your kidneys and generate multiple important hormones such as epinephrine (adrenaline) and cortisol. Think of them as responsible with the “fight or flight” response when you’re stressed out, scared, or excited. These glands are essential because if they don't function correctly, one can develop chronic fatigue and mild signs of depression. Studies show that approximately 40% of people over 60 have to deal with constant tiredness associated with reduced adrenal function. We all live stressful lives and have to juggle a thousand daily problems and responsibilities. This makes the adrenal glands pump a lot of cortisol and adrenaline into the body. Too many hormones can make someone feel very stressed, mildly depressed, and fatigued. Poor sleep quality can also worsen the problem because the adrenal glands tend to recover when the body is at rest. Most people don’t get enough sleep during the night, so these glands don’t get a chance to rejuvenate properly. Add periodic stimulants to the equation (alcohol and drugs), and the load on the adrenal glands can quickly become overwhelming. Adrenal problems don’t only translate into constant fatigue. Dizziness, poor concentration, anxiety and panic attacks, etc also accompany them. A complete fatigue panel looks at the hormones produced by the adrenal glands and determines if they are in sufficient quantities. For example: The DHEA test looks at the levels of DHEA-S in the body. This is an androgen hormone, and if it is in excessively high quantities, the person in question might suffer from adrenal hyperplasia. Similarly, if the levels of DHEA-S are insufficient, this can lead to chronic fatigue. The salivary cortisol test is also essential in determining the differences in cortisol levels at different moments of the day. Patients will be asked to collect four saliva samples during the day, and this will indicate whether the adrenal glands function correctly or they produce too much cortisol regularly.   Immune system tests As you probably already know, the immune system is responsible for neutralizing viruses and bacteria which get in the body so you don’t get sick all the time. It relies on a series of cells, such as the T cells and other hormones, to identify viruses and eliminate them before they get a chance to multiply. An immune system that functions properly requires energy.Suppose there is too much inflammation in the body (as a result of injury, being exposed to a lot of viruses and toxins, etc.). In that case, this system will work overtime to protect your health, and it will consume vast amounts of energy, leaving you tired and in a bad mood. A complete fatigue panel includes tests that measure the number of white cells in the bloodstream. These cells are responsible for neutralizing viruses and bacteria as well. In some rare cases, the bone marrow might not produce sufficient white cells, which can signify a more severe problem.   Iron tests Iron is an essential element in the body, as it produces red blood cells that help carry oxygen to organs and tissues. Anemia, which is characterized by exhaustion, wooziness, and a general feeling of weakness, can result from not having enough iron in one's body. A fatigue panel looks at different hormones in the body which are responsible for metabolizing and storing iron. For example: The ferritin test looks at the ferritin levels in the bloodstream. This protein is responsible for storing iron, and if its levels are insufficient, one can develop anemia, which leads to excessive tiredness. One reason ferritin levels might be low is that one donates too much blood each year. Studies show that donating blood more than twice a year can deplete ferritin levels, leading to anemia. The TIBC test (total iron binding capacity) looks at the absolute levels of iron available in the bloodstream. If this value is too high, then the amounts of iron in the body are insufficient, which can cause excessive fatigue. FAQ 1. Do I need to fast before getting tested? Doing a fasting session of 8-12 hours is recommended before drawing blood. Also, biotin supplementation should be stopped 72 hours before being tested. 2. How quickly are the results delivered? You will usually get the results by email in a few business days. 3. What specimens are submitted for testing? Fatigue panels require patients to submit a blood specimen and, in some cases, a saliva specimen for testing. The instructions on managing and properly collecting these samples are provided within the package, so you will know precisely what to do. 4. What should I do after I get the results? Your healthcare provider will interpret your results and, if necessary, will suggest effective treatment options. For example, if you have iron deficiency and this is the leading cause of your fatigue, you’ll be guided to supplement with iron for some time. Similarly, suppose low testosterone or thyroid hormone blood levels cause your fatigue. In that case, you'll be advised to explore solutions such as Testosterone Replacement Therapy (TRT) or thyroid hormone replacement to help deal with your fatigue problem. 5. Is this test safe? Yes! The submission of samples and results analysis is entirely confidential, and you’ll be drawing blood in a medical setting under specialized supervision.   Conclusion Diagnosing chronic fatigue is not easy, but you’re one step closer to feeling better by ordering a comprehensive fatigue panel. Order the complete fatigue panel today from Discounted Labs, and you can drastically improve the quality of your life!   BUY THE COMPREHENSIVE FATIGUE BLOOD TEST PANEL HERE    

Introduction to the Study The Baltimore Longitudinal Study of Aging recently published a study called "The Relationship Between C-Reactive Protein and Total Testosterone in Aging Men." This study shows how C-Reactive Protein (CRP) levels, low testosterone, and chronic inflammatory diseases in older men are connected in complex ways. Elevated CRP and low testosterone are common in older adults and are linked to several chronic diseases like cancer, diabetes, and cardiovascular disease. Understanding the Role of Testosterone Testosterone plays a crucial role in modulating inflammation. Testosterone Replacement Therapy (TRT) has been observed to reduce CRP levels in aging, hypogonadal (low testosterone) men. Cross-sectional studies have shown that CRP levels are lower than total testosterone (TT) levels. This suggests a strong link, though there are differences when looking at different parts of metabolic syndrome. Study Objective: Analyzing CRP and Testosterone Levels The primary objective of this study was to evaluate the relationship between CRP and TT levels in men over a 14-year period, using data from the Baltimore Longitudinal Study of Aging. The research aimed to establish whether low androgen status (low testosterone levels) correlates with high inflammatory profiles, independent of other comorbidities. Methodology: A Cohort Study The study involved male participants with serum TT levels measured during two separate visits over three years apart. Key variables like CRP, high-density lipoprotein (HDL), and triglyceride levels were collected through blood samples, along with comorbidity data at each visit. Panel regression analysis was utilized to delve into the relationship between these variables over time. Results: Testosterone Levels and Inflammation Out of 347 patients (average age 69), the study found a median CRP level of 1.0 mg/dL and a median TT level of 446 ng/dL. The results highlighted a significant association between increased TT levels and a decline in CRP levels, independent of comorbidities. Interestingly, factors like age, congestive heart failure, diabetes, HDL, and triglycerides did not significantly predict CRP levels. Conclusions: Implications for Testosterone Therapy The study concludes that lower serum total testosterone levels are associated with increased CRP in older men. This finding underscores the potential health benefits of TRT in managing chronic diseases in older, hypogonadal men by restoring testosterone levels. It highlights a critical aspect of aging male health and the importance of monitoring and potentially treating low testosterone levels. Elevate Your Health with Testosterone Testing At Discounted Labs, we understand the importance of monitoring your health as you age. Regular testosterone testing can be a crucial step in maintaining your well-being and preventing chronic diseases. Visit us at DiscountedLabs.com to learn more about our affordable and convenient blood tests, available without a doctor's visit in several U.S. states. Take charge of your health today and ensure your testosterone levels are within a healthy range.

Except for estradiol, no hormone is more misunderstood than dihydrotestosterone, or DHT. Many men fear DHT, going out of their way to use a DHT blocker for their medical condition. However, DHT is a critical hormone, one that men need for sexual and prostate health, cognitive function, skeletal strength, and many other reasons. Like everything in life, there are downsides to DHT, but the upside of healthy DHT levels far outweighs the challenges it can present. It is crucial to choose a DHT blocker that has support from scientific research in order to ensure both safety and efficacy when considering its use for hair thickness and general health care. In the intricate world of hormones and their impact on men's health, Dihydrotestosterone (DHT) often emerges as a topic of considerable debate and intrigue. This potent androgen, frequently overshadowed by its more famous counterpart testosterone, plays a pivotal role in numerous physiological processes yet is often misunderstood or feared due to its association with certain medical conditions. Our journey in this article is to demystify DHT, unraveling its complexities to reveal not just the concerns it raises but, more importantly, the indispensable benefits it offers for male health. From sexual wellness to cognitive abilities and skeletal integrity, DHT's influence is far-reaching, making it essential to understand and appreciate its role in the broader context of hormonal balance and overall health. DHT – FRIEND OR ENEMY? Except for estradiol, no hormone is more misunderstood than dihydrotestosterone, or DHT. Many men fear DHT, going out of their way to lower it and frustrate its biological activity. However, DHT is a critical hormone, one that men need for sexual and prostate growth, cognitive function, skeletal strength, and many other reasons, such as hormonal health conditions. Like everything in life, DHT has downsides, but the upside of healthy DHT levels far outweighs the challenges it can present. DHT, the main hormone involved in male-pattern hair loss, can attach to receptors in your scalp and damage your hair follicles, leading to a receding hairline, hair thinning, and even severe hair loss. DHT – Where it Comes From The principal hormone produced in men is, of course, testosterone. When testosterone is produced by the testicles (or injected or absorbed by a man on testosterone replacement), an enzyme, 5-alpha reductase(5-AR), sets to work, converting a portion of that testosterone to DHT, which is the conversion of testosterone into the androgen hormone dihydrotestosterone (DHT). This conversion prevents some testosterone from reaching the androgen receptors in the brain, genitals, skin, and other tissues. Initially, that may sound like the body is deprived of a needed hormone, testosterone. However, for the most part, this conversion is actually in a man’s best interest. Though estimates vary, DHT binds much more efficiently to androgen receptors; DHT is 300 to 500 percent more efficient at reaching and binding to the receptors and is far more potent than testosterone. If tissues were deprived of DHT, 5-AR hadn’t done its job; there would be dramatic physiological changes. While it is true that testosterone remains the primary, active androgen in muscle and muscle development, DHT is still critical for testosterone's full performance-enhancing effects. Specifically, the impact of DHT on the central nervous system increases neurological efficiency and strength. The production of body hair DHT comes from testosterone, with the help of the enzyme 5-alpha reductase (5-AR). The production of DHT is a natural process that occurs when testosterone is converted into the androgen hormone dihydrotestosterone (DHT) with the help of the enzyme 5-alpha reductase (5-AR). DHT – Positive Effects  To understand DHT’s androgenic properties, consider the following. Male Development – Physical and sexual development in the human male is DHT-dependent. DHT is responsible for the growth and development of the penis, the prostate, and the testicles. It not only helps with sex differentiation during fetal development but also supports the changes that occur during puberty and adulthood. Libido – DHT supports a healthy sex drive. Men with optimal levels of the hormone report a far stronger drive than men with lower levels. Prostate Health – Men with balanced levels of DHT may have fewer prostate health issues. Cognitive Function – One study indicated that administering DHT to men between 34 and 70 resulted in memory improvements. The androgenic properties of the hormone encouraged the retrieval of stored memories and the archiving of new ones. Low/lower levels of DHT were linked to a decline in cognitive function in elderly men. Blood Sugar Management – Higher levels of DHT help to reduce the risk of diabetes by controlling sugar levels and preventing hyperglycemia. DHT can improve insulin sensitivity, support efforts to lose weight, and may provide adjunctive support in treating diabetes.  Cardiovascular Health – Men with coronary artery disease may benefit from higher levels of DHT since lower hormone levels have been shown to increase the risk of cardiovascular disease. It may be a simple association – higher levels of DHT might lower the mortality associated with heart disease. Stroke Risk – Researchers followed a group of men for six years and learned that higher levels of DHT and testosterone seemed to lower the risk of stroke.  Depression – In one study, men who used finasteride, a drug that blocks 5-AR and, thus, generates lower levels of DHT, had higher rates of depression than a control group. DHT may well be necessary to support mental and emotional health. Anti-Aging – Higher levels of DHT, testosterone, and estradiol seem to slow the decline associated with aging. Lower levels of all three hormones brought about cellular changes seen in the elderly. Higher levels were associated with “younger” cellular function. Bone and Skeletal Health – Along with estradiol, appropriate levels of DHT support and maintain bone density in men. DHT – The Downside The DHT story is firm but not universally positive. The drawbacks of DHT must be considered. Baldness – Hair loss is probably the number one DHT—harmful in the minds of most men who are involved in testosterone therapy. Studies have shown that higher levels of DHT are linked to increased male-pattern baldness. In women, elevated levels of DHT can lead to male-like hair growth patterns. Cancer – DHT is critical for the normal development of the prostate, but high hormone levels have been associated with prostate cancer risk. However, studies on DHT and prostate cancer are contradictory. Acne – Inflammatory acne flares have been linked to DHT.  DHT – The Bottom Line: A Friend or Foe? For men, DHT is a friend and an important one. However, like virtually every hormone in the body, the key to health is balance. If DHT levels drop too far, men open themselves to low libido.  DHT is not likely to be tested in most men undergoing testosterone replacement therapy. Some clinicians fail to recognize the importance of DHT for men’s health and libido, so they fail to monitor it. It’s entirely possible, even likely, that some men are not obtaining the maximum benefits of testosterone replacement because (unbeknownst to them) their DHT levels are not optimal.  DiscountedLabs.com offers a highly affordable DHT test to help you determine if your body is producing sufficient DHT. The DHT test is quick, easy to administer, and reliable.   How to Increase DHT There are natural ways to boost DHT levels if one is not on a testosterone replacement protocol. Here are a few things that can be done. Exercise more, particularly resistance training and high-intensity training. Increase your intake of caffeine, creatine, or green tea supplements. Boost the amount of zinc in your diet via the food you eat or a supplement. Take a DHEA supplement if your DHEA blood level is low. Get a DHEA blood test Lose weight. Optimize your testosterone blood level, which is low. Last but not least, use a scrotal testosterone cream. Applying compounded (alcohol-free) testosterone cream to the testicular skin has increased DHT considerably. Using a DHT Blocker to Lower DHT It should be clear that most men have no reason to suppress their DHT levels. However, Propecia is regularly prescribed as a DHT blocker for men anxious about losing their hair, specifically to address male pattern baldness (a.k.a. androgenic alopecia). As was noted, Propecia will stop or suppress the 5-AR activity that produces DHT, thereby reducing DHT production. By blocking or slowing the work of 5-AR, one of the possible adverse side effects that DHT can have, male pattern baldness, may be prevented or arrested. Unfortunately, there is scientific evidence that some men who take this medication may risk lowering their libido and mood. In many cases, using DHT blockers like finasteride can help you to slow down or stop androgenic hair loss and even stimulate growth, allowing people to slow down or prevent hair loss and maintain a full head of thicker, healthier hair well into their 40s, 50s, and 60s. Topical finasteride is not FDA-approved yet but has shown promise in clinical studies. It can be sold by compounding pharmacies with a prescription. For reasons still not clearly understood, this medication can produce a syndrome in some men very similar to those symptoms associated with hypogonadism. Loss of libido, weak erections, malaise, and fatigue plague many men even after they have stopped using the drug. While it’s true that no one wants to lose their hair, no man wants to wind up with what has come to be known as post-finasteride syndrome. With proper attention, DHT can be a friend and ally in the search for optimal health. Don’t fear it; accept it and have it work to your advantage. Conclusion Navigating the intricate landscape of DHT and its role in men's health requires a nuanced understanding that balances the pros and cons. While concerns like male pattern baldness and potential links to certain health issues cannot be overlooked, the substantial benefits of DHT in areas like sexual health, cognitive function, and metabolic regulation highlight its critical role. The key lies in achieving hormonal equilibrium and ensuring that DHT levels are maintained within an optimal range. For those considering testosterone replacement therapy or DHT blockers, it's crucial to make informed decisions based on a comprehensive understanding of DHT's impact and the latest scientific research. At DiscountedLabs.com, we offer affordable and reliable DHT testing, empowering you to make the best choices for your health and wellbeing. Remember, DHT is not just a hormone to be managed but a vital component of a balanced and healthy male physiology.   Buy Your DHT TEST on DiscountedLabs.com  

What Are the Symptoms of Low Testosterone (Deficiency)? Hypogonadism is the medical term for a male condition caused by the body not producing sufficient amounts of testosterone. Most people don’t realize that, in addition to sexual desire, testosterone also affects lean body mass, strength, bone density, mental focus, mood, fat loss, and other essential factors in both males and females. Common complaints for men with hypogonadism include lower sexual desire (libido), erectile dysfunction (softer erections or lack of erections), depression, low energy and appetite, changes in body composition (lower lean body mass and higher abdominal fat), lower strength, reductions in body and facial hair, less mental focus, decreased height, and osteoporosis (decrease in bone density). A list shows that normalizing testosterone in people with lower-than-normal levels has dramatic benefits, including increased sexual desire, lean body mass, bone density, strength, mood, motivation, mental focus, and stamina. However, these benefits can be erased if proper monitoring, dose adjustment, and an appropriate choice of testosterone replacement option are not accomplished. Benefits of Normalizing Testosterone Restored sexual desire Improved erectile function Improved mood or sense of wellbeing Increased lean body mass, strength, and stamina Improved bone density Decreased fat mass Determining If You Have Testosterone Deficiency In addition to blood tests and physical examinations, researchers at St. Louis University have also developed a brief screening instrument to aid in diagnosing hypogonadism. Known as the Androgen Deficiency in the Aging Male (ADAM) Questionnaire: Do you have a decrease in sex drive? Do you lack energy? Have you experienced a decrease in strength and endurance? Do you feel shorter? Have you lost height? (Lower bone density can decrease size.) Have you noticed a decreased enjoyment of life? Are you sad and grumpy? Are your erections less strong or gone? Has it been more challenging to maintain your erection throughout sexual intercourse? Are you falling asleep after dinner? Has your work performance deteriorated recently?   Other questions that are usually not asked by doctors but which I’ve found to be important are the following:   Are you relating well to the people around you? • Are you able to pay attention when someone talks to you? • Are you loving your lover or life partner? Are you able to pay attention when someone talks to you? Several of the abovementioned problems can be caused by many other issues unrelated to low testosterone. Depression, anxiety, stress, medications, and sleep disorders can cause nine of those ten symptoms (a decrease in height would be the only item unrelated to bone loss or back surgery). This questionnaire is not a perfect predictor of low testosterone and should not replace tests for testosterone blood levels. The benefit of this questionnaire is that it may encourage some men to seek medical advice.  Then they can get their testosterone checked and have a physical examination to help determine whether they are indeed hypogonadal. Causes of Testosterone Deficiency Hypogonadism is caused when the testicles fail to produce normal levels of testosterone. Testosterone levels are low in one type of hypogonadism, while LH and FSH are elevated. In another, there is not enough secretion of LH and FSH needed to tell the testicles to produce the required testosterone. Some commonly used medications, such as Megace (an appetite stimulant), Nizoral (an anti-fungal agent), Prednisone (an anti-inflammatory corticosteroid), and Tagamet (an antacid), can also lower testosterone production. Illness and aging can cause a decrease in testosterone and an increase in sex hormone-binding globulin (SHBG). Furthermore, high prolactin hormone levels may suggest a pituitary tumor, causing a decline in testosterone production. It is essential that your doctor measure hormones in the HPGA cascade to diagnose what kind of hypogonadism you have. The most common type of hypogonadism presents low testosterone with normal or elevated FSH and LH levels, which indicates that your testicles are not responding to the signals of both LH and FSH. This is what is called primary hypogonadism.   There are several reasons why testosterone levels may be low: SHBG is binding too much free testosterone. This would be especially apparent if a male’s total testosterone level is in the high reference range but his free testosterone (unbound) level is low. As previously mentioned, aging and illness increase SHBG. The pituitary gland, which controls testosterone production through the production of LH, is not secreting enough LH to stimulate the production of testosterone by the testicles. In this case, total testosterone would be low. The hypothalamus is not functioning correctly. LH levels of less than two ng/mL suggest a lesion in this part of the HPGA. The testicles have lost their ability to produce testosterone, despite adequate LH. In this case, the level of LH would be high (greater than ten ng/mL) despite a low testosterone level. Dehydroepiandrosterone (DHEA) levels are abnormally low. DHEA is a hormone produced by the adrenal glands that has many of the same benefits as testosterone. It is also a precursor to testosterone in women. Disease or infection. Street drugs, prescription or over-the-counter medications (more on this later) Lab error. High prolactin levels may indicate the presence of a pituitary tumor that impairs the production of hormones that tell your testicles to produce testosterone (rare condition but worth mentioning!) Defects in genes that affect LH and FSH production. Buy Testosterone Lab Tests on DiscountedLabs.com    

Embarking on the path of Testosterone Replacement Therapy (TRT) often evokes a blend of enthusiasm and concern among men. The allure of renewed vigor, heightened sexual desire, and robust muscle growth is enticing. However, there are a lot of less well-known aspects that your healthcare provider might not immediately disclose. For instance, were you aware that TRT could affect your fertility or exacerbate your sleep apnea? While TRT heralds a new dawn for many, it doesn’t offer a universal remedy. In light of this, we have meticulously curated a comprehensive list of 18 pivotal aspects that might elude your doctor's attention but are indispensable for you to grasp. Venture further to unearth the profundities of TRT. Low Blood Levels of Testosterone and Associated Risks: < 450 ng/dl (15.3 nmol/l) - Risk of metabolic syndrome Reference: Dhindsa, S., Miller, M. G., McWhirter, C. L., Mager, D. E., Ghanim, H., Chaudhuri, A., & Dandona, P. (2010). Testosterone concentrations in diabetic and nondiabetic obese men. Diabetes Care, 33(6), 1186-1192. PubMed < 400 ng/dl (15.3 nmol/l) - Venous leakage (internal penile damage) risk Reference: Yassin, A. A., & Saad, F. (2017). Testosterone Deficiency and Testosterone Treatment in Older Men. Gerontology, 63(2), 144–156. PubMed < 350 ng/dl (11.9 nmol/l) – All-cause death risk and anemia risk Reference: Khaw, K. T., Dowsett, M., Folkerd, E., Bingham, S., Wareham, N., Luben, R., ... & Day, N. (2007). Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men. Circulation, 116(23), 2694-2701. PubMed < 300 ng/dL (10.2 nmol/L) - Lowered libido, weight gain & Diabetes risk increased Reference: Traish, A. M., Saad, F., & Guay, A. (2009). The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction Journal of Andrology, 30(1), 10-22. PubMed < 300 ng/dL (10.2 nmol/L): Quartile risk of fractures (osteoporosis), memory-related issues and depression risk increases Reference: Orwoll, E., Lambert, L. C., Marshall, L. M., Phipps, K., Blank, J., Barrett-Connor, E.,... & Cummings, S. (2006). Testosterone and estradiol are common among older men. The Journal of Clinical Endocrinology & Metabolism, 91(4), 1336-1344. PubMed < 250 ng/dl (8.5 nmol/l): Arterial plaque (arteriosclerosis) & sleep quality affected Reference: Vlachopoulos, C., Ioakeimidis, N., Miner, M., & Aggelis, A. (2014). Testosterone deficiency: a determinant of aortic stiffness in men Atherosclerosis, 233(1), 278-283. PubMed < 235 ng/dl (8.0 nmol/l) hardening of arteries (dialysis patients) Reference: Carrero, J. J., Qureshi, A. R., Parini, P., Arver, S., Lindholm, B., Bárány, P., ... & Stenvinkel, P. (2009). Low serum testosterone increases mortality risk among male dialysis patients. Journal of the American Society of Nephrology, 20(3), 613-620. PubMed < 200 ng/dl (6.8 nmol/l) morning erections decrease Reference: O'Connor, D. B., Lee, D. M., Corona, G., Forti, G., Tajar, A., O'Neill, T. W., ... & EMAS Study Group. (2011). The relationships between sex hormones and sexual function in middle-aged and older European men. The Journal of Clinical Endocrinology & Metabolism, 96(10), E1577-E1587. PubMed < 150 ng/dl (5.1 nmol/l) - Increased inflammation (TNF-alpha) Reference: Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004). The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. The Journal of Clinical Endocrinology & Metabolism, 89(7), 3313-3318. PubMed The Unspoken Implications of TRT Your doctor might overlook mentioning certain ramifications when you commence Testosterone Replacement Therapy (TRT): Fertility and TRT Sperm Count Drop: TRT lowers the levels of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), two hormones that help make sperm. If preserving fertility is a priority, discuss with your healthcare provider incorporating Clomiphene or hCG into your TRT regimen. Hematological Effects Blood Viscosity Increase: TRT can escalate your blood's hematocrit level, thereby increasing its viscosity. Although some practitioners may advise halting TRT, this side effect can be managed adeptly through blood donations or therapeutic phlebotomy. Beware; frequent blood donations might deplete iron levels and induce fatigue. Impact on Natural Testosterone Production Suppression of Endogenous Testosterone: TRT suppresses your body’s natural testosterone synthesis, which may rebound anywhere between a few weeks and six months post-cessation. The Multifaceted Benefits and Varied Efficacy of TRT Muscle Mass, Fat Reduction, and Sexual Health Sex Drive and Physique Enhancement: TRT predominantly augments libido, muscle mass, and fat metabolism in men. However, its effectiveness varies, and meticulous dosage and frequency adjustments along with side effect management are imperative. It’s not a panacea. Administration Techniques Methods of Injection: Contrary to what most people think, testosterone can be injected superficially (IM) or deeply (subcutaneously) into the muscle using a 1/2-inch, 27-29-gauge insulin syringe. Topical Testosterone Efficacy of Gels and Creams: Testosterone gels and creams are efficacious but often under-dosed by physicians. More concentrated compounded products or dosage adjustments based on blood levels can rectify this. Dosage Frequency Optimized Injection Schedules: Shifting from biweekly 200mg injections to weekly 100mg or twice-weekly 50mg dosages can often yield better results. Addressing Concerns and Optimizing TRT Outcomes Sleep Apnea and TRT Sleep Apnea Dynamics: TRT could exacerbate central sleep apnea but might alleviate obstructive sleep apnea over time as weight loss occurs. Erectile Function Erectile Function and Libido: TRT enhances erectile function and libido in a majority of men. Some may benefit from adjunctive low-dose daily Cialis, which also harbors cardiovascular advantages. Self-Monitoring and Telemedicine Monitoring Blood Tests: Companies like DiscountedLabs.com enable self-monitoring of blood tests without a doctor visit. Moreover, telemedicine facilitates access to testosterone doctors nationwide, albeit mostly without insurance coverage. Debunking Misconceptions and Enhancing TRT Knowledge Prostate Health and Cardiovascular Effects Prostate Cancer and Heart Attacks: Contemporary evidence refutes the notion that TRT triggers prostate cancer or heart attacks, though vigilant monitoring is crucial for optimal cardiovascular outcomes. Community Support and Knowledge Sharing Leveraging Online Communities: Engage with seasoned TRT users on platforms like the ExcelMale forum or Testosterone Replacement Discussion Facebook group to broaden your understanding. Comprehensive Testing Holistic Blood Analysis: Ensure your doctor conducts a thorough blood analysis encompassing total and free testosterone, DHT, thyroid function, and prolactin (especially for those with extremely low T levels) to rule out pituitary adenomas. Insurance, Professional Expertise, and Addressing Common Hurdles Insurance and TRT Insurance Coverage: Insurance coverage for TRT products is often restrictive, but utilizing a compounding pharmacy can be a viable alternative. Expertise in TRT Management Urologists Leading the Charge: The burgeoning expertise of urologists in TRT management is notable, with extensive TRT-centric discussions now a staple at urology conferences. Identifying and Addressing Co-morbidities Co-morbid Conditions: Men with co-existing health issues may encounter challenges in reaping TRT benefits, warranting a thorough cardiovascular assessment for those experiencing water retention and hypertension. Estradiol Management Misconceptions About Estradiol: People often get the wrong idea about this hormone, which plays a big part in libido, bone health, and brain function, because it is not given enough attention when it comes to management. Emerging evidence suggests aromatase inhibition might be unnecessary in TRT management. Armed with this extensive knowledge, you’re now better positioned to make informed decisions on your TRT journey. Remember, individualized consultation with healthcare professionals is indispensable for optimizing your TRT experience.    

Although testosterone frequently overshadows estradiol, a hormone more commonly associated with women, estradiol plays a significant role in men's health. Derived from testosterone through a process known as aromatization, estradiol contributes to various physiological aspects in men. Although it's crucial for maintaining bone density, its role in sexual health, body composition, and other health parameters is subject to ongoing discourse. Here, we delve into the dynamics of estradiol in men, its implications, and the importance of accurate measurement. Understanding Estradiol in Men The hormone estradiol, although present in smaller quantities in men compared to women, is produced through the aromatization of testosterone in liver, fat, and other cells. This conversion is nature’s design, hinting at a purpose behind it. Besides promoting bone health, estradiol’s influence on men's libido, body composition, and other factors is a hot topic among researchers. Excessive levels of estradiol, especially alongside low testosterone levels, could lead to conditions like gynecomastia (enlarged breasts in men). Hormonal Balance: The HPT Axis The Hypothalamic-Pituitary-Testicular (HPT) axis is a hormonal cascade that adjusts testosterone production based on the levels of testosterone and estradiol in the body. When either hormone level goes up too high, the HPT axis responds by decreasing the production of testosterone to keep hormone levels in balance. Aromatase Inhibitors: Boon or Bane? Aromatase inhibitors (AIs) stop the production of estradiol and are often given to people who are getting testosterone replacement therapy (TRT) to help them look younger and stay healthy. While higher estradiol levels could potentially cause gynecomastia and water retention, there's speculation, albeit without scientific backing, linking high estradiol levels to erectile dysfunction. The use of AIs is thought to mitigate these issues by lowering estradiol levels. However, the exact threshold of estradiol levels in men, beyond which it could be detrimental, remains undefined. Unveiling the Optimal Range Recent studies have started to shed light on estradiol's optimal range. For instance, levels below 20 pg/ml have been associated with increased bone loss, higher fat mass, and diminished sexual function in men. It is very important to get a correct reading of estradiol, and it is better to use a sensitive estradiol test (LC/MS assay) instead of the more common ECLIA-based test to avoid getting wrongly high estradiol readings from things like CRP (C-reactive protein). Estradiol’s Diverse Effects: A Closer Look 1. Bone Density: A study showed that estradiol levels below 11 pg/ml were linked to increased bone loss in men, emphasizing estradiol's role in bone health (Source). 2. Libido and Erectile Function: One groundbreaking study revealed that lower estradiol levels were correlated with increased body fat and a decrease in sexual desire and erectile function (Source). 3. Mortality Rate: A study highlighted that men with estradiol levels either below 21.80 pg/ml or above 30.11 pg/ml had a higher mortality rate, indicating a potential sweet spot for estradiol levels (Source). 4. Testosterone Therapy: In men undergoing TRT, elevated estradiol levels were associated with heightened libido, suggesting a nuanced interplay between testosterone and estradiol (Source). Conclusion The journey to demystify estradiol's role in men is ongoing. While its importance in bone health is well acknowledged, the hormone's broader impact on male physiology is gradually being unraveled. Accurate estradiol measurement and a deeper understanding of its optimal range could pave the way for enhanced men's health management, particularly for those undergoing testosterone replacement therapy.     Here is a more detailed discussion on estradiol in men: Click here   How to Get a sensitive estradiol test  

The prostate gland plays a pivotal role in men’s health, and its well-being is often a topic of great concern, especially when it comes to prostate cancer, a leading cause of death among men in the United States. This article delves into the intricacies of prostate health, detection methods for prostate cancer, and the debated connection between testosterone replacement therapy (TRT) and prostate cancer. Prostate Cancer Prevalence and Detection As men age, the occurrence of small, hidden prostatic lesions increases, which could potentially turn cancerous over time. The prevalence of these lesions is around 30% in American men aged over 45, and this figure soars to over 80% for those above 80 years of age. The transformation of these lesions into cancerous cells is often linked to genetic factors and lifestyle conditions, including diet. To detect prostate cancer, healthcare providers employ a variety of methods: Prostate-Specific Antigen (PSA) assays Digital Rectal Examination (DRE) Transrectal Ultrasound It's advisable for men, especially those above 40 or with a family history of prostate cancer, to undergo a DRE before commencing testosterone replacement therapy and every six months thereafter. While DRE may be uncomfortable, it's a small price to pay for ensuring good health. Any abnormal rectal exam findings, a PSA increase of more than 2 ng/mL, or a PSA level over 4 ng/mL usually necessitate further evaluation by a urologist, often involving an ultrasound and prostate biopsies. However, the PSA and DRE methods lack sensitivity and specificity. In some instances, benign prostatic hyperplasia (BPH), a non-cancerous inflammation, may falsely elevate PSA levels, while 25% of prostate cancer patients show normal PSA levels. As it turns out, needle biopsies can find hidden prostatic lesions in men whose PSA levels and ultrasound results are normal. Testosterone Replacement Therapy and Prostate Cancer: Unveiling the Connection The role of Testosterone Replacement Therapy (TRT) in PSA elevation or prostate cancer development has been a topic of considerable debate. Prostate cancer is initially androgen-dependent; thus, TRT is discouraged for men diagnosed with prostate cancer. However, a comprehensive analysis encompassing data from 18 studies revealed no significant link between blood levels of androgens and an increased risk for prostate cancer (Journal of the National Cancer Institute, 2008). Intriguingly, some emerging data suggest that high doses of testosterone may be beneficial in treating certain types of prostate cancer. A different study that looked at 149,354 men who were diagnosed with prostate cancer between 1991 and 2007 found that those who were treated with TRT did not have higher rates of death or use of Androgen Deprivation Therapy (ADT). The study, published in the Journal of Sexual Medicine (2014), concluded that TRT, post-prostate cancer diagnosis and treatment, doesn't exacerbate mortality rates or the necessity for ADT, even with prolonged TRT duration. Conclusion The dialogue surrounding prostate cancer, its detection, and the implicated role of TRT is complex. While the journey towards unambiguous understanding continues, regular screenings and open discussions with healthcare providers remain crucial for maintaining prostate health and making informed treatment decisions.   Reference: Kaplan, A. L., Lenis, A. T., Shah, A., Rajfer, J., & Hu, J. C. (2014). Testosterone Replacement Therapy in Men with Prostate Cancer: A Time-Varying Analysis. Journal of Sexual Medicine. For more insights on this topic, refer to: Does Testosterone Cause Prostate Cancer? Can Men Treated for Prostate Cancer Use TRT?