Testosterone Blood Tests

Is 2ml of Testosterone a Week Enough to Build Muscle? Study Results Testosterone is a hormone that plays many roles in the body, like building muscle, increasing strength, sexual health, and overall well-being. People wonder how much testosterone is needed to achieve these benefits, especially when considering testosterone replacement therapy (TRT) for muscle growth. Those with low testosterone might be considering TRT to feel better. But figuring out the right testosterone dose to use is tricky because it depends on your age, health, diet, exercise program, and how your body reacts to the treatment. In this article we will be looking at a study by Dr. Bhasin and his colleagues in 2001 published in the American Journal of Physiology and Endocrinology Metabolism. Their study was to see how different amounts of testosterone affect young men and what’s the best dose for different results. By going through what they found out we can learn a lot about what’s the right amount of testosterone for getting stronger or building muscle. Watch video here: What is the Optimal Testosterone Dose? Testosterone and Muscle Growth Testosterone is a hormone that plays a big role in muscle growth and development. Produced mainly in the testicles in men, testosterone is responsible for the development of male characteristics, including muscle mass and strength. As men age, their testosterone levels decline naturally, which can lead to a decrease in muscle mass and strength. This decline can affect overall health and well-being, so it’s important to understand the connection between testosterone and muscle growth. For those who want to build muscle, maintaining optimal testosterone levels is crucial. Testosterone stimulates protein synthesis, which is the process by which the body repairs and builds muscle tissues. Higher testosterone levels can increase muscle mass, strength, and overall health. By understanding how testosterone affects muscle growth, you can make informed decisions about your fitness and health goals. Testosterone Replacement Therapy (TRT) for Muscle Growth Testosterone Replacement Therapy (TRT) is a treatment for those with low testosterone. TRT involves injecting, gelling, or patching testosterone to restore normal testosterone levels. This is especially good for those experiencing symptoms of low testosterone such as decreased muscle mass, fatigue, and decreased libido. TRT can increase muscle mass and strength, bone density, and overall health. By restoring testosterone levels, TRT supports the body’s natural ability to build muscle and perform physically. But please note that TRT should only be done under the guidance of a doctor. While TRT can be beneficial, it also has side effects and risks, like increased red blood cell production and changes in cholesterol levels. So medical supervision is necessary to ensure safe and effective treatment. The Study In the study, about 65 young men around 25 years old and in good shape were studied. The study also included 1 ml of testosterone as part of the dosage variations. First they stopped their bodies from making testosterone naturally by giving them a drug that blocks testosterone. Then for 20 weeks they gave these men shots of a type of testosterone called cypionate once a week. The dose varied from 25 milligrams to 600 milligrams a week. By doing this, they could see how different doses affect different things. Testosterone Dose and Hormone Levels The study found a correlation between the dose of testosterone and the levels of different hormones in the body. They looked at total testosterone, free testosterone, LH (luteinizing hormone), SHBG (sex hormone-binding globulin), and IGF-1 (insulin-like growth factor 1). Here’s what they found out: As the dose of testosterone increased, so did the total testosterone levels in the body. At the beginning, the subjects had testosterone levels of 500-600 ng/dL. By week 16, those who got higher doses (300-600 mg/week) had levels of 1300-2300 ng/dL. Even with a smaller dose of 125 mg/week, the subjects had levels near what they started with. So taking around 100-125 mg/week might be enough for young men to get their testosterone back to normal. Free testosterone: Just like total testosterone, as more was given, free testosterone increased. So more dosage means more free testosterone is available in your system. LH and SHBG: The more testosterone you take, the lower these levels go. As people increase their dose of testosterone, they see a drop in LH and also in SHBG. So taking more testosterone can slow down LH production and decrease SHBG. So more free testosterone is available for your body to use. Testosterone dosage for muscle growth and body composition The study looked into how different doses of testosterone affect muscle building, muscle size, and body composition. They used various methods to measure lean muscle mass (fat-free mass) and body fat. Here’s what they found out: For fat-free mass, the study found that 100-125 mg of testosterone per week helped people gain muscle without fat. Those who took these doses had less body fat and more muscle. Even more (300-600 mg/week) gave better results in gaining muscle without fat. But the smallest doses (25-50 mg/week) didn’t do much; sometimes they even added fat. For body fat, it seems that higher doses help reduce it. Those who got 100-125 mg per week lost body fat. Those who got very low doses (25-50 mg/week) didn’t lose weight or might have added body fat. So high levels of this hormone can make you leaner by cutting down fatty tissues while increasing muscle growth. Factors to Consider in Testosterone Dosage Determining the right testosterone dosage for TRT involves considering age, health status, and individual goals. Age is a big factor, as older men may need different dosages than younger men due to natural hormonal decline. Men with underlying health conditions such as cardiovascular disease or metabolic disorder may need customized dosages to ensure safety and effectiveness. Individual goals also matter in determining testosterone dosage. For example, someone looking to improve overall health may need a different dosage than someone looking to gain massive muscle and bodybuilding. Personalized treatment plans are necessary to address these individual needs and goals. Working with a doctor is key to determining the right dosage. Regular blood tests and monitoring can help adjust the dosage as needed to keep testosterone levels within normal range. By considering these factors and working with a medical professional, you can get the best out of your TRT. Testosterone Dose and Sexual Function and Libido The study also looked into how different doses of testosterone affect sexual function and desire. To find out they asked participants to fill out questionnaires about their sex life and how much they wanted sex. Here’s what they found out: For sexual activity, the study didn’t show much change in how often people were sexually active when they took more testosterone. The frequency of sexual encounters remained the same across all doses. Note that there were not many participants in this study, so this might have affected the results. For libido, it was found that 300-600 mg/week of testosterone gave a slight increase in desire. But 25-125 mg/week didn’t make much of a difference in libido. So higher doses used by bodybuilders might be more effective in increasing sexual desire. No Change in Cognitive Function In the study they also looked into how well people can think and remember. But even with different doses of testosterone, there was no big change in brain function. Note that this study was done on young guys. To know if testosterone affects thinking and memory in older men more studies need to be done. Testosterone Dose and Strength and Power In the study they tested the strength and power of participants’ legs by having them do leg press for 20 weeks. What they found out was interesting—the amount of testosterone given to the participants made a difference in how much stronger or more powerful their legs became. Those who got 300-600 mg/week had a significant increase in strength and power of their legs. So taking higher doses of testosterone can make you stronger and more powerful even if you don’t work out. Hemoglobin, Hematocrit and Cholesterol Levels Giving testosterone changes blood counts and fat levels in the body. The results match what we already know: Hemoglobin: As testosterone dose increased, so did hemoglobin levels. So as more testosterone is given more hemoglobin goes up. This means treatment with testosterone can affect erythropoiesis, which is how our body makes red blood cells. Just like hemoglobin, when testosterone doses go up, so does hematocrit. Hematocrit is all about how much space red blood cells take up in our blood. The study didn’t specify what’s the ideal level of hematocrit is, but note that too much can be bad for your heart health. Lipid Profile: The administration of testosterone caused a fluctuation in the levels of HDL cholesterol, the beneficial type. When you have more testosterone in your system, your HDL cholesterol tends to decrease. So it’s really important to monitor lipid profiles if you’re on testosterone therapy. Conclusion In 2001 Dr. Bhasin and his team did a study that looked into how different doses of testosterone affect several factors. Although the study was done on young men and had a small number of participants, it still gives us valuable information on how testosterone levels relate to muscle size, sexual health, brain function, physical strength, and blood-related measures. According to the study, 100-125 mg/week may be enough for young men to get their testosterone levels back to normal. For bodybuilding, 300-600 mg/week seems to increase muscle size, strength, and sex drive. But we have to remember that people react differently to each other. So any treatment with testosterone should be customized for each person’s needs and monitored by a healthcare professional who knows what he’s doing. Note that the study was done more than 20 years ago. Since then there might be new findings. If you’re thinking of testosterone therapy, talk to medical experts. They can assess your situation and give you personalized advice. The study provides valuable insights into the functioning of testosterone dosing, highlighting the need for further investigation. By doing more research, we can make the most of testosterone therapy and minimize the downsides. Get a budget-friendly testosterone test without seeing a doctor. Buy a testosterone test from DiscountedLabs.com and find out your testosterone blood level and adjust your TRT dose. FAQs Is 2 ml of testosterone a week enough to build muscle? The study above showed that 125 mg/week of injectable testosterone was enough to increase muscle. 2 ml of testosterone is 400 mg/week which will increase muscle but may cause high hematocrit, water retention, and blood pressure. How much test cypionate a week for bodybuilding? The study above showed that 125 mg/week of test cypionate is enough to increase muscle in bodybuilding without TRT side effects. References: In a study titled "Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study", researchers looked at how hormone levels, including testosterone, change as men get older. The article "Testosterone Replacement in Older Men: A Clinical Perspective" discusses the benefits and considerations of giving older men testosterone to improve their health. According to research found on Harvard's website, scientists have figured out what dose of testosterone works best for women. Another study called "Effects of Testosterone Treatment on Body Fat and Lean Mass in Obese Men on a Hypocaloric Diet: A Randomized Controlled Trial" explores how taking testosterone can help obese men lose fat but keep muscle while eating fewer calories.

Testosterone Injection: Subcutaneous vs. Intramuscular—Where to Inject Regardless of which TRT product you’ve been prescribed, a common question is where to inject testosterone. For decades, most men have used IM testosterone injections, primarily into the glutes, quads, or deltoids, using a 1 to 1.5-inch syringe. During the past five years, many men have also begun injecting testosterone subcutaneously (SubQ), a shallow injection into the fat layer on the abdominal or other areas—just under the skin but before reaching muscle. Many TRT patients find SubQ injections less bothersome than IM injections, as they require a smaller needle in both length and gauge. SubQ injections are also associated with less irritation for some men with IM injections. While some men may find IM injections to leave a minor soreness at the injected site, SubQ injections cause no noticeable pain or irritation. Understanding Testosterone Replacement Therapy Testosterone Replacement Therapy (TRT) is a medical treatment designed to help individuals with low testosterone levels, also known as hypogonadism. TRT aims to restore normal testosterone levels, alleviating symptoms such as low libido, fatigue, and decreased muscle mass. This form of hormone therapy can significantly improve the quality of life for those experiencing sexual dysfunction and other related issues. TRT can be administered through various methods, including intramuscular injections, subcutaneous injections, and topical gels. In this article, we will focus on testosterone injections, specifically intramuscular and subcutaneous injections, to provide a comprehensive understanding of these methods. Testosterone Injection Methods: Effects on Total Testosterone, Estradiol (E2), and PSA Testosterone Cypionate and Testosterone Enanthate are the two most commonly used forms of testosterone in men to treat hypogonadism (low testosterone). Both forms carry the same testosterone hormone; the ester is the only difference, which alters the hormone’s time release so that testosterone blood levels can remain up for a few days. These two testosterone compounds are identical in a testosterone replacement therapy (TRT) setting. Both forms are commonly used in hormone replacement therapy to treat hypogonadism in men. Where and How to Inject Testosterone? Regardless of which TRT product you’ve been prescribed, a common question is where to inject testosterone. For decades, most men have injected their testosterone intramuscularly (IM), primarily into the glutes, quads, or deltoids, using a 1- to 1.5-inch syringe. During the past five years, many men have also begun injecting testosterone subcutaneously (SubQ), a shallow injection into the fat layer on the abdominal or other areas—just under the skin but before reaching muscle. Many TRT patients find SubQ injections less bothersome than IM injections, as they require a smaller needle in both length and gauge. SubQ injections are also associated with less irritation for some men with IM injections. While some men may find IM injections to leave a minor soreness at the injected site, SubQ injections cause no noticeable pain or irritation. Many patients find it beneficial to inject weekly to maintain stable testosterone levels. Administering Testosterone Injections Safely Administering testosterone injections safely requires proper technique and precautions to ensure effectiveness and minimize risks. Before injecting, ensure the injection site is clean and free of any debris. Use a sterile needle and syringe, and follow the recommended dosage and injection frequency as prescribed by your healthcare provider. For intramuscular injections, use a longer needle (1 to 1.5 inches) and insert it at a 90-degree angle into the muscle, typically in the glutes, quads, or deltoids. For subcutaneous injections, use a shorter needle (0.5 to 1 inch) and insert it at a 45-degree angle into the fatty tissue, commonly in the abdominal area. Always dispose of used needles and syringes properly to prevent injury and contamination. By following these steps, you can administer testosterone injections safely and effectively. Choosing the Right Injection Site Choosing the right injection site is crucial for safe and effective testosterone injections. For intramuscular injections, common sites include the buttocks, thigh, and upper arm. These areas have larger muscle masses, which are ideal for proper absorption of the hormone. For subcutaneous injections, common sites include the abdomen, thigh, and buttock. When selecting an injection site, consider the following factors: Fat layer: Subcutaneous injections require a sufficient fat layer to ensure proper absorption. Muscle mass: Intramuscular injections require a larger muscle mass to ensure proper absorption. Nerve proximity: Avoid injecting near nerves to minimize the risk of nerve damage. Scarring: Rotate injection sites to minimize scarring and promote even absorption. By carefully choosing the injection site and rotating locations, you can enhance the effectiveness of your testosterone injections and reduce potential complications. What is the Best Way to Inject Testosterone? While subcutaneous testosterone injections are by far the most uncomplicated and most comfortable, the more critical question for any TRT patient is how effective this method is and how it affects the potential adverse side effects of TRT. Weekly injections are often recommended to maintain stable hormone levels and reduce side effects. A recent study from the Department of Urology at the University of California (UC) has provided us with such answers. The UC study attempted to answer four questions as they relate to IM vs. SubQ testosterone injections: Comparisons in: Total Testosterone Hematocrit (HCT) Estradiol (E2) Prostate-Specific Antigen (PSA) Two hundred thirty-two men took part in the UC study. Baseline levels were recorded for all men in the four measurement areas and then again at 6-12 weeks post-treatment. The results showed that men who underwent SubQ injections of testosterone resulted in a 14% greater increase in total testosterone levels than the testosterone level of IM patients. SubQ patients also had 41% lower hematocrit post-therapy than IM patients and 26.5% lower E2 levels. For both groups of men, there were no elevated levels of PSA. Additional Studies Comparing IM versus SubQ TRT While the UC study provides valuable data on four specific lab test values of concern and is one of the most recent studies on the topic of subcutaneous versus intramuscular testosterone injections, it is not the only information we have available. An additional Journal of Clinical Endocrinology study found that normal serum testosterone levels were maintained through SubQ injections. Most patients preferred the injection method due to less injection site pain. Similar results were found in a study headed by Dr. Al-Futais in a Canadian study that ran for one year in 2002. Similar results for subcutaneous testosterone injections have also been found in female-to-male (FTM) transgender people-based testosterone studies. The Journal of Clinical Endocrinology and Metabolism reported that FTM patients administering SubQ testosterone were found to easily reach stable and normal testosterone levels along with suitable E2 levels. The study concluded that SubQ testosterone injections are both safe and effective. These findings are particularly relevant for those undergoing gender-affirming hormone therapy, as they highlight the effectiveness and patient preference for SubQ injections. Although far less in-depth than we previously mentioned, a final study of note was published in the Journal of the Endocrine Society. Similar results to the reviews mentioned above were found, along with no significant changes between IM and SubQ patients relating to dihydrotestosterone (DHT). Interestingly, unlike the UC study, this study also measured no notable difference in E2 levels between the two categories. However, it must be noted that this particular study only included a single injection of testosterone undecanoate at 1000 mg. How to Inject Testosterone Using Subcutaneous Injections? If subcutaneous testosterone injections are right for you, you will merely need a small insulin syringe to administer the hormone. A 0.5-inch-long, 25-27 gauge needle in a 1 ml syringe will typically suffice. They also do not require aspiration, commonly used in old IM injection techniques. Unlike IM testosterone injections, SubQ injections do not require aspiration and use a smaller needle. Regardless, the aforementioned insulin needles and syringes are your best choice for comfort and ease of use. Due to the small needle size, you may find it slightly more difficult to draw the testosterone into the insulin syringe. But most men on TRT use 50-100 mg twice per week, which amounts to 0.25 to 0.5 ml of a 200 mg/ml testosterone cypionate or enanthate formulation commonly used in the United States. Those small volumes load up in just 1-2 minutes. Many TRT clinics prescribe protocols to patients to inject their testosterone subcutaneously once or twice weekly. This protocol effectively maintains stable testosterone levels with small, more frequent doses than the old dose of 200 mg once every two weeks. Two injections that split the weekly dose twice per week will suffice for most patients, such as a Monday and Thursday protocol. Is There Any Difference Between Testosterone Cypionate and Testosterone Enanthate? As mentioned early on, testosterone cypionate and testosterone enanthate are the two most commonly prescribed and lowest-cost testosterone esters worldwide. All four studies cited in our discussion were performed using Testosterone Enanthate, excluding the one using Undecanoate. However, using Testosterone Cypionate would have yielded similar, if not identical, results. Both versions of the testosterone hormone are just that, testosterone. Molecularly, there is no difference. It is merely the ester attached, and the carrier oil it may be mixed in is the only difference. Further, as the enanthate and cypionate esters have very similar time-release structures, total serum levels should be relatively the same with either compound, even if injected subcutaneously. Conclusion In conclusion, testosterone replacement therapy is a medical treatment designed to help individuals with low testosterone levels. Administering testosterone injections safely requires proper technique and precautions. Choosing the right injection site is crucial for safe and effective testosterone injections. By understanding the differences between intramuscular and subcutaneous injections, individuals can make informed decisions about their treatment options. Always consult with a healthcare professional before starting testosterone replacement therapy to ensure the best approach for your specific needs. References How to Inject Testosterone Intramuscularly, Shallow IM, or Subcutaneously? Comparison of Outcomes for Hypogonadal Men Treated with Intramuscular Testosterone Cypionate versus Subcutaneous Testosterone Enanthate SIU Academy. Choi E. 10/10/20; 309864; BSP-06.01 Subcutaneous Injection of Testosterone Is an Effective and Preferred Alternative to Intramuscular Injection: Demonstration in Female-to-Male Transgender Patients  The Journal of Clinical Endocrinology & Metabolism, Volume 102, Issue 7, 1 July 2017, Pages 2349–2355 Pharmacokinetics and Acceptability of Subcutaneous Injection of Testosterone Undecanoate J Endocr Soc. 2019 Aug 1; 3(8): 1531–1540.

High AST and ALT in Bodybuilding: How Weight Training Can Affect Liver Function Understanding Liver Function Tests Liver function tests (LFTs) are essential tools in assessing an individual’s overall health. These tests evaluate the liver’s ability to perform its vital functions, such as detoxification, metabolism, and the production of essential proteins. By measuring specific enzymes and proteins in the blood, LFTs can detect liver damage or disease, allowing for early intervention and treatment. In the context of exercise and muscle damage, LFTs are particularly valuable as they help differentiate between liver damage and muscle damage, which can both cause elevated liver enzymes. Importance of Liver Function Tests in Monitoring Health Liver function tests play a crucial role in monitoring an individual’s health. They provide insights into the liver’s performance and can detect early signs of liver damage or disease. Elevated liver enzymes, such as ALT and AST, can indicate liver inflammation or damage. However, these enzymes can also be released into the bloodstream due to muscle damage from strenuous exercise. By conducting LFTs, healthcare professionals can determine whether elevated liver enzymes are due to liver damage or muscle damage, ensuring accurate diagnosis and appropriate treatment. What Liver Function Tests Measure Liver function tests measure the levels of various enzymes and proteins produced by the liver. The most common LFTs include: Alanine transaminase (ALT): An enzyme that helps convert proteins into energy for liver cells. Elevated levels can indicate liver damage. Aspartate transaminase (AST): An enzyme found in the liver and other tissues, such as the heart and muscles. Elevated levels can indicate liver or muscle damage. Alkaline phosphatase (ALP): An enzyme related to the bile ducts; often increased when they are blocked or inflamed. Gamma-glutamyl transferase (GGT): An enzyme involved in the metabolism of drugs and toxins. Elevated levels can indicate liver or bile duct damage. Bilirubin: A waste product from the breakdown of red blood cells. Elevated levels can indicate liver dysfunction or bile duct problems. These tests help identify liver damage or disease and monitor the effectiveness of treatment, providing a comprehensive picture of liver health. Normal Ranges for Liver Enzymes The normal ranges for liver enzymes can vary slightly depending on the laboratory and the individual’s age, sex, and other factors. Generally, the normal ranges are: ALT: 0-40 U/L AST: 0-40 U/L ALP: 30-120 U/L GGT: 0-60 U/L Bilirubin: 0.1-1.2 mg/dL It’s important to note that these ranges can vary, and a healthcare professional should interpret the results in the context of the individual’s overall health and medical history. Understanding these normal ranges is crucial for accurately interpreting liver function tests and diagnosing potential liver issues. High AST and ALT in Bodybuilding: How Weight Training Can Affect Liver Function Understanding Liver Function Tests Liver function tests (LFTs) are essential tools in assessing an individual’s overall health. These tests evaluate the liver’s ability to perform its vital functions, such as detoxification, metabolism, and the production of essential proteins. By measuring specific enzymes and proteins in the blood, LFTs can detect liver damage or disease, allowing for early intervention and treatment. In the context of exercise and muscle damage, LFTs are particularly valuable as they help differentiate between liver damage and muscle damage, which can both cause elevated liver enzymes. Importance of Liver Function Tests in Monitoring Health Liver function tests play a crucial role in monitoring an individual’s health. They provide insights into the liver’s performance and can detect early signs of liver damage or disease. Elevated liver enzymes, such as ALT and AST, can indicate liver inflammation or damage. However, these enzymes can also be released into the bloodstream due to muscle damage from strenuous exercise. By conducting LFTs, healthcare professionals can determine whether elevated liver enzymes are due to liver damage or muscle damage, ensuring accurate diagnosis and appropriate treatment. What Liver Function Tests Measure Liver function tests measure the levels of various enzymes and proteins produced by the liver. The most common LFTs include: Alanine transaminase (ALT): An enzyme that helps convert proteins into energy for liver cells. Elevated levels can indicate liver damage. Aspartate transaminase (AST): An enzyme found in the liver and other tissues, such as the heart and muscles. Elevated levels can indicate liver or muscle damage. Alkaline phosphatase (ALP): An enzyme related to the bile ducts; often increased when they are blocked or inflamed. Gamma-glutamyl transferase (GGT): An enzyme involved in the metabolism of drugs and toxins. Elevated levels can indicate liver or bile duct damage. Bilirubin: A waste product from the breakdown of red blood cells. Elevated levels can indicate liver dysfunction or bile duct problems. These tests help identify liver damage or disease and monitor the effectiveness of treatment, providing a comprehensive picture of liver health. Normal Ranges for Liver Enzymes The normal ranges for liver enzymes can vary slightly depending on the laboratory and the individual’s age, sex, and other factors. Generally, the normal ranges are: ALT: 0-40 U/L AST: 0-40 U/L ALP: 30-120 U/L GGT: 0-60 U/L Bilirubin: 0.1-1.2 mg/dL It’s important to note that these ranges can vary, and a healthcare professional should interpret the results in the context of the individual’s overall health and medical history. Understanding these normal ranges is crucial for accurately interpreting liver function tests and diagnosing potential liver issues. The Impact of Weight Training on Elevated Liver Enzymes If you have high levels of transaminases, especially alanine transaminase (ALT) and aspartate transaminase (AST), it could mean that your liver is damaged or even has cancer, or it could mean that you are hitting the gym hard. Vigorous exercise, such as intense weightlifting, can also cause a temporary increase in liver enzyme levels. The liver has transaminases, such as ALT levels, to synthesize and break down amino acids and to convert energy storage molecules. The concentrations of these transaminases in the serum (the non-cellular portion of blood) are normally low. However, if the liver is damaged, the liver cell (hepatocyte) membrane becomes more permeable, and some of the enzymes leak out into the blood circulation. A blood test can show elevated liver enzymes. The blood test checks for raised levels of AST and ALT, which are enzymes that the liver releases when it becomes inflamed or damaged. If a doctor finds that a person has raised AST or ALT levels, they are likely to carry out further tests to determine the underlying cause of liver damage, such as acute viral hepatitis, chronic viral hepatitis, or cirrhosis of the liver. Other medical conditions can increase liver enzymes, like hepatitis B or C and a condition that runs in families called hemochromatosis. Chronic liver disease, such as non-alcoholic steatohepatitis (NASH), can also lead to elevated liver enzymes. Liver Enzyme Tests and Exercise The two transaminases commonly measured as part of a liver function panel are alanine transaminase (ALT) and aspartate transaminase (AST). These levels were previously called serum glutamate-pyruvate transaminase (SGPT) and serum glutamate-oxaloacetate transaminase (SGOT). Elevated levels are sensitive to liver injury, meaning that they are likely to be present if there is an injury. However, they may also be elevated in other conditions such as thyroid disorders, celiac disease, and muscle disorders. Elevated liver enzymes can also be a result of drug-induced liver injury, which requires careful interpretation of liver function tests to distinguish from exercise-induced elevations. Additionally, several studies have described enzyme elevations in response to running, whereas only a few have dealt with the effects of weight training. The effects of muscular exercise on clinical chemistry parameters may also vary depending on gender and the fitness level of the individual. But before 2008, no research looked at how weightlifting might affect lab tests that are often used to check how well the liver is working, how long that effect might last, or whether people with weightlifting had yellow eyes or skin, which is a common sign of jaundice. The gamma-glutamyltransferase (GGT) test is another liver enzyme test that can provide valuable insights into liver and bile duct damage. The Effect of Weight Training on Liver Enzyme Tests: Study The Swedish study, which was published in the February 2008 issue of the British Journal of Pharmacology, looked at what happened to liver enzymes in healthy men who did heavy weightlifting just once. The men were not used to doing heavy weightlifting regularly. A second goal was to look into what effect a single bout of intense muscle exercise (weightlifting) had on creatine kinase (CK) and myoglobin, two clinical chemistry markers that show muscle damage. Fifteen healthy men, used to moderate physical activity, not including weightlifting, performed a 1-hour-long weight training program. The following clinical chemistry parameters were measured in the blood: aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LD), gamma-glutamyl transferase (γGT), alkaline phosphatase (ALP), bilirubin, creatine kinase (CK), and myoglobin. These tests were done several times during the first week after exercise and again 10–12 days later. Five out of eight studied clinical chemistry parameters (AST, ALT, LD, CK, and myoglobin) increased significantly after exercise (P < 0.01) and remained increased for at least 7 days post-exercise. Bilirubin, γGT, and ALP remained within the normal range. The liver function parameters, AST and ALT, were significantly increased for at least 7 days after the exercise. In addition, LD and, in particular, CK and myoglobin showed highly elevated levels. These results show how important it is to limit weightlifting before and during clinical studies so that wrong assumptions are not made about how study drugs might hurt the liver. This is particularly important in patients with pre-existing liver disease, where elevated enzyme levels could be misinterpreted. Intensive muscular exercise, e.g., weightlifting, should also be considered as a cause of asymptomatic elevations of liver function tests in daily clinical practice. Muscle Damage and Liver Enzymes Exercise-Induced Muscle Damage and Liver Enzyme Release Exercise-induced muscle damage can lead to the release of liver enzymes, such as AST and ALT, into the bloodstream. This occurs because muscle tissue contains these enzymes, and when muscle damage happens, they are released into the blood. Strenuous exercise, like weightlifting, can cause significant muscle damage, leading to a temporary increase in liver enzymes. This increase can sometimes be misinterpreted as liver damage, but it usually resolves on its own once the muscle damage heals. It’s essential to recognize that muscle damage can also result from other factors, such as muscle conditions, medication use, or other medical conditions. A healthcare professional should evaluate the individual’s overall health and medical history to determine the cause of elevated liver enzymes. In the context of exercise, it’s important to consider the type and intensity of the activity, as well as the individual’s fitness level and medical history. High-intensity exercises, such as weightlifting, can cause more significant muscle damage compared to low-intensity activities like yoga. Understanding this distinction helps in accurately interpreting liver function tests and avoiding misdiagnosis. In conclusion, liver function tests are vital in monitoring an individual’s overall health. Understanding the normal ranges for liver enzymes is crucial for interpreting the results accurately. Exercise-induced muscle damage can lead to the release of liver enzymes, but this increase is usually temporary and resolves once the muscle damage heals. A healthcare professional should evaluate the individual’s overall health and medical history to determine the cause of elevated liver enzymes, ensuring accurate diagnosis and appropriate treatment. Doctors Need to Know that Exercise Can Increase Liver Enzymes Liver function tests are significantly increased for at least 7 days after weight training among men used to moderate physical activity but not used to performing weight training on a regular basis. In line with these findings and to rule out any possible exercise-related effects on liver function tests, it is important to limit weight training for at least one week before the start of clinical trials. The study also shows how important it is to think about weight training and probably other types of intense muscle training as possible causes of liver function tests that are elevated without any symptoms in everyday clinical practice. This will reduce the risk of erroneously attributing changes in liver function tests to a drug effect. Recognizing liver enzyme alteration due to exercise is crucial for accurate diagnosis and treatment. This is especially important for men on testosterone replacement therapy (TRT) who usually work out, and that may have led physicians to wrongly assume that TRT is causing liver abnormalities. Additionally, individuals with high blood pressure should also be cautious when engaging in weight training to avoid any potential impact on liver function. People can work with their doctor to treat NAFLD with weight loss. The doctor may advise a person to make lifestyle changes to lose weight, such as exercising more, eating a healthy, balanced diet, and trying to burn more calories than they consume. Speaking with a nutritionist or even a personal trainer can help someone stay on track with their weight-loss plan. Alcohol consumption can exacerbate the effects of weight training on liver function and should be avoided to maintain liver health. Reference: Br J Clin Pharmacol. 2008 Feb; 65(2): 253–259.  

Testosterone is typically thought of as a hormone for men. Still, it is also essential for women as it influences sexual functioning, mood, the development of lean muscle mass, and even memory and cognition. Women who are in their 40s have about half the level of testosterone that was present in their 20s. We see a significant decline in testosterone levels over time. Women with low or suboptimal testosterone levels can experience many symptoms, including sexual dysfunction and a decrease in sexual drive or desire, known as low sex drive (hypogonadism). They can also notice that they have increased fatigue. They're tired. Also, it's more challenging to develop lean muscle mass. It can have a significant impact even on mood, an overall sense of well-being, motivation, a feeling of confidence, and assertiveness. Also, it can affect memory and cognitive function. A low libido: As testosterone helps fuel a healthy sex drive, a decline in sexual interest or inability to achieve orgasm may be a symptom of lower testosterone levels in both sexes. A study published in the journal of the American Medical Association showed that approximately 43% of postmenopausal women suffer from some form of sexual dysfunction. Surprisingly, we don't hear a lot about this condition in women. We certainly don't hear about options for treatment, including testosterone. This condition can often go undiagnosed and undertreated. NO FDA-APPROVED TREATMENTS FOR LOW TESTOSTERONE ON WOMEN Currently, there is no FDA-approved testosterone replacement therapy for women, even though providers have been prescribing it in an off-label manner, which is when a medication is prescribed for something other than its official FDA-approved indication. Providers have been doing this for over 50 years now. Testosterone can be replaced in various forms. It can be given in a shallow-dose injection once a week. It can also be given sublingually in a troche form, which dissolves in the mouth. Also, it can be administered through a minor surgical procedure. It's known as subcutaneous pellet insertion. And then it can also be given in topical form as a cream or a gel. The most common form of replacement we see is topical gel or cream, which can be supplied by compounding pharmacies. The benefit of doing it this way is that the provider can adjust the dose based on the individual patient's needs and response to therapy. It's more than just one standard dose, and it better work for you, or there's no other option.  Testosterone creams can be customized for the needs of the individual patient. When you replace any hormone in this manner at low daily doses, it is very similar to the way the body naturally produces hormones. After starting testosterone replacement therapy, women typically notice a significant improvement in all symptoms, including increased sexual functioning, desire, and drive. They can also see an increase in energy levels and an increased ability to develop lean muscle mass. Additionally, they can notice a significant improvement in mood, motivation, overall sense of well-being, and confidence. In addition, they may see improved memory and cognitive functioning. Another critical point is that when testosterone is given to a woman, a portion of it will convert to estrogen. The postmenopausal woman with low estrogen levels can see improvement in those symptoms typically associated with low estrogens, such as hot flashes, night sweats, moodiness, irritability, and vaginal dryness. So, women may experience improvements in the classic symptoms of low testosterone and the typical menopausal symptoms associated with low estrogen. Several studies support the use of hormone replacement therapy, specifically testosterone replacement therapy, in women. A Cochrane review of the literature found that over 35 trials have been performed, which included over 4500 women. They found a significant improvement in sexual functioning in women on hormone replacement therapy. Also, a more recent study published in 2014 showed that women on a transdermal or topical form of hormone replacement therapy had an improvement in memory and cognitive functioning. Several studies support the use of this vital hormone in women. POTENTIAL SIDE EFFECTS OF TESTOSTERONE IN WOMEN In terms of safety, there are potential side effects with the use of any medication. In testosterone therapy, if doses are too high, women can notice adverse effects, such as acne and an increase in hair growth, known as hirsutism. Also, with extremely high doses, they may see a deepened voice or enlargement of the labia or clitoris. That would typically be something that's dose-dependent. If a physician was a little bit aggressive with their starting dose, they might notice some side effects of testosterone treatment, such as disturbed breathing while sleeping, breast swelling or tenderness, swelling in the ankles, or too much testosterone. Doctors also watch out for high red blood cell counts, which could increase the risk of clotting. By decreasing and backing off on the dosage, those symptoms will resolve. One important fact to mention for premenopausal women who are still menstruating is that providers need to discuss the use of birth control with them because testosterone is considered category X, meaning it will cause fetal harm if a woman becomes pregnant while she's on testosterone replacement. That's just a discussion that the patient needs to have with their provider, “What is your reliable form of birth control?" before prescribing it to them. Testosterone replacement therapy is very safe for premenopausal women on birth control and postmenopausal women. It has a low risk of side effects when used at appropriate doses, and many studies support its use in this population. SEXUAL DYSFUNCTION AND LOW TESTOSTERONE IN WOMEN We are all aware that if we watch TV for more than an hour each day, we will constantly see advertisements for medications to treat erectile dysfunction in men. But we hardly hear anything about sexual dysfunction in women. There are many reasons why women’s sexual desire and other hormone-related quality-of-life issues are so misunderstood, underdiagnosed, and undertreated. Sexual dysfunction in pre and post-menopausal women has been a very controversial topic that has been poorly researched, even though a February 1999 study published in the Journal of the American Medical Association, titled “Sexual Dysfunction in the United States: Prevalence and Predictors,” found that approximately 43% of postmenopausal women suffer from some form of female sexual dysfunction. It wasn’t until June 2011 that an FDA advisory committee to the division of Reproductive and Urologic Drug Products stated that HSDD (Hypoactive Sexual Desire Syndrome) is a significant medical condition for women. This may open the door for companies to apply for new drug applications for that indication. It is important to note that unlike erectile dysfunction drugs approved for men, like Viagra, which increase blood flow to the genitals as long as a man is aroused, testosterone therapy is systemic and needs to be applied over weeks to have a noticeable effect on sex drive in men and women. Some companies have tried to enter the female sexual dysfunction market in the past. In December 2004, the United States FDA rejected Procter & Gamble's fast-track request for Intrinsa (a testosterone patch for women) for HSDD, citing concerns about potential off-label use of the product. In Canada, post-menopausal women have been able to obtain government-approved testosterone treatment since 2002. In 2007, Intrinsa was granted a license from the European Medicines Agency in July and was available on Britain's National Health Service. According to P&G's survey on female health, 30 million women in the U.S. are naturally menopausal, 3 million are distressed by their lack of sexual desire, and 20% of 25 million surgically menopausal women are distressed. Other companies that attempted to get their drugs approved for this indication (Boehringer Ingelheim and Warner Chilcott) have pulled the plug on their competing HSDD treatments for menopausal and pre-menopausal women. BioSante Pharmaceuticals also got their testosterone gel for women, LibiGel, rejected by the FDA. HORMONE THERAPY IN POSTMENOPAUSAL WOMEN Menopause can cause symptoms such as hot flashes that might result from the changing hormone levels during the menopause transition. After a woman's last menstrual period, when her ovaries make much less estrogen and progesterone, some symptoms of menopause might disappear, but others may continue. To help relieve these symptoms, some women use hormones. This is called hormone therapy (HT), which includes estrogen alone or in combination with progesterone. HT is available orally or in gel formulations made by specialized compounding pharmacies. Estrogen is a hormone used to relieve the symptoms of menopause. A woman who had her uterus removed could use only estrogen (E). But a woman with a uterus must add progesterone, or progestin (synthetic progesterone), and estrogen (E+P). This combination lowers the chance of an unwanted thickening of the uterus lining and reduces the risk of cancer of the uterus, an uncommon but possible result of using estrogen alone. CONTROVERSIES IN HORMONE TREATMENTS FOR WOMEN But the use of hormone therapy in women has been subject to much controversy in the recent past. The Women's Health Initiative (WHI) was a landmark clinical trial that looked at the effects of combination hormone therapy (estrogen + progestin) in 16,608 postmenopausal women with an intact uterus. The women were aged 50 to 79 (average age of 63) when they joined the study. This study did not include the use of testosterone. In this study, 8,506 participants were randomly assigned to receive a combination of estrogen (0.625 milligrams of conjugated equine estrogens per day) plus progestin (2.5 mg of medroxyprogesterone acetate), and 8,102 women were given a placebo.  The study was stopped in 2002 after an average of 5.6 years of treatment due to increased breast cancer in women on hormone therapy. Compared to women on placebo, women on combination hormone therapy were also at increased risk of stroke, dangerous blood clots, and heart disease. In contrast, their risk of colorectal cancer and hip fractures was lower. It is important to note that these hormones were provided orally, and some clinicians claim that transdermal (on the skin) application of estrogen alone or in combination with testosterone would show a different and more favorable side effect profile. The halting of the WHI study raised concerns about the safety of all hormone therapy in women (oral or transdermal), even if no androgens were included in this study and only oral delivery forms were used. Many physicians stopped prescribing hormone therapy (HT) even for women who had dramatic improvements in their quality of life while using it. Experts today don't recommend hormone therapy unless a woman suffers painful menopause symptoms. New information about the use of androgens (testosterone and DHEA) alone or with HT suggests that these hormones may help women who do not have enough androgens and have problems with their sexual health. Androgens are also precursors of all estrogens (estrone (E1), estradiol (E2), and estriol (E3)) in women's bodies. The primary and most well-known androgen is testosterone (which aromatizes into estradiol); other less essential androgens are dihydrotestosterone (DHEA) and androstenedione. The ovaries and adrenals directly secrete androgens in women. Presently, there is no agreement about whether androgen deficiency is a clinical problem in aging women and if the addition of androgens to HT can improve the cardiovascular risks seen in the WHI study. Causes of androgen insufficiency in women can have ovarian, adrenal, hypothalamic-pituitary, drug-related, and unknown origins. Symptoms of adrenal insufficiency and androgen insufficiency in women may include a diminished sense of well-being, low mood, fatigue, and hypoactive sexual desire disorder (HSDD) with decreased libido or reduced sexual receptivity and pleasure that causes a great deal of personal distress. Premature ovarian insufficiency (POI) is another possible cause of androgen insufficiency in women. POI occurs when the ovaries stop functioning normally before 40 years of age. Although menopause is the most common cause of ovarian failure, other factors, such as chemotherapy or radiation therapy, can also contribute to POI. Therefore, it is important to consider premature ovarian insufficiency as a potential cause of androgen insufficiency in women. There is increasing evidence to suggest that many postmenopausal women experience symptoms alleviated by androgen therapy and that such symptoms may be caused by androgen deficiency. Affected women complain of fatigue, low libido, and diminished well-being, which are symptoms easily and frequently attributed to psychosocial and environmental factors. The question of whether adding testosterone therapy to conventional postmenopausal HT is effective or safe is unresolved. Therefore, a Cochrane review was performed to determine the efficacy and safety of testosterone therapy for postmenopausal women using HT. Thirty-five trials with a total of 4768 participants were included in the review. The median study duration was six months (range: 1.5 to 24 months). Most of the trials were of adequate quality regarding randomization. The pooled estimate suggested that adding testosterone to HT regimens improved sexual function scores and the number of satisfying sexual episodes for postmenopausal women. Some of the few adverse effects were decreased high-density lipoprotein (HDL) cholesterol levels and increased hair growth and acne incidence. The discontinuation rate was not significantly higher with the addition of testosterone therapy. OTHER USES FOR TESTOSTERONE IN WOMEN Emerging and controversial potential indications for androgen therapy in women have been or are being evaluated. Women with early ovarian failure, premenopausal androgen deficiency symptoms, postmenopausal and glucocorticosteroid-related bone loss, HIV-related wasting, and the premenstrual syndrome can all use this medicine. Whether or not any of these indications will lead to approved products in the future is unknown. HOW TO MEASURE LOW TESTOSTERONE IN WOMEN The term hypogonadism is used as a diagnostic term for testosterone deficiency, also known as testosterone insufficiency, in men. Besides HSDD as one of the potential symptoms, there is no agreement on what to call androgen deficiency in women. Clinical guidelines published in 2002 called the Princeton Consensus Statement used the term "female androgen insufficiency" as defined as a pattern of clinical symptoms in the presence of decreased bioavailable testosterone and normal estrogen status. The panel warned that currently available testosterone assays were found to lack sensitivity and reliability at the lower testosterone blood level ranges in women. The need for an equilibrium dialysis measure was strongly emphasized as the most adequate method to test women’s testosterone blood levels. BUY THE MOST AFFORDABLE AND ACCURATE TESTOSTERONE TEST FOR WOMEN Women in the United States can buy a testosterone test for women online without needing a doctor's prescription by using DiscountedLabs.com. They can also obtain a complete blood test panel to measure other hormones like estrogen, DHEA, progesterone, and testosterone. HOW TO TREAT LOW TESTOSTERONE IN FEMALES Circulating testosterone in women declines during the late reproductive years, such that otherwise healthy women in their 40s have approximately half the testosterone level as women in their 20s. The levels remain stable across the menopausal transition and then either remain stable or continue to decline with diminishing adrenal androgen production with increasing age. In the decade preceding menopause, the mid-cycle surge of free testosterone is lost. Despite this, research showing the benefits of androgen replacement has been limited to postmenopausal years. This means that testosterone levels in women change throughout the month based on one's menstrual cycle. However, the mid-cycle surge of free testosterone is lost in the decade preceding menopause. Some small studies have been done in premenopausal women, however. One evaluated the efficacy of transdermal testosterone therapy on mood, well-being, and sexual function in premenopausal women with low libido in eugonadal (normal testosterone blood levels). Testosterone therapy improved the well-being, mood, and sexual function of these women. Since many women experience diminished sexual interest and welfare during their late reproductive years, further research is warranted to evaluate the benefits and safety of the longer-term intervention. Potential dose-dependent side effects may be unwanted hair growth, masculinization, and high-density lipoprotein (HDL) lowering. TESTOSTERONE REPLACEMENT AND CARDIOVASCULAR RISKS IN WOMEN A direct association between testosterone and heart disease has never been established, but doctors have suspected a link exists for many years. The reasoning goes like this: men have much more testosterone than women and develop heart disease about ten years before their female counterparts. On top of standard medical therapy, women with systolic heart failure who took low-dose testosterone for six months showed significant gains in exercise and ventilatory capacity and large-muscle strength, along with heightened insulin sensitivity, in a small placebo-controlled trial . Despite the entrenched belief that higher blood levels of testosterone increase the risk of CVD in women, data from recent observational studies mostly show an inverse relationship between testosterone and CVD risk. A pilot study (JCEM 86 (1): 158) suggested favorable effects of transdermal testosterone treatment of women with established congestive cardiac failure, which merits further evaluation. Some early research shows that giving postmenopausal women testosterone therapy through injections improves both flow-mediated and GTN-mediated vasodilation in the brachial artery. The mechanisms underlying these potentially beneficial cardiovascular effects require further investigation. TESTOSTERONE REPLACEMENT AND CANCER IN WOMEN The relationship between endogenous testosterone production and breast cancer risk remains contentious, with recent studies indicating either no relationship or a possible increase in risk when estrone and estradiol are not considered. No randomized controlled trial of testosterone therapy has been sufficiently large or of sufficient duration to establish whether such treatment may influence breast cancer occurrence. There does not appear to be an association between testosterone and endometrial cancer or other malignancies in the review of published studies. There is no convincing evidence that standard estrogen-based hormone therapy for ovarian failure increases the risk of breast cancer. However, some studies have previously shown that ovarian androgens protect mammary epithelial cells from excessive estrogenic stimulation. Therefore, a study hypothesized that adding testosterone to usual hormone therapy might protect women from breast cancer. This retrospective observational study followed 508 postmenopausal women receiving testosterone and standard hormone therapy in South Australia. Breast cancer status was ascertained by mammography at the initiation of testosterone treatment and biannually after that. The average age at the start of follow-up was 56.4 years, and the mean duration of follow-up was 5.8 years. Breast cancer incidence in this group was compared with that of untreated women and women using usual hormone therapy reported in the medical literature and to age-specific local population rates. There were seven cases of invasive breast cancer in this population of testosterone users, for an incidence of 238 per 100,000 woman-years. The rate for estrogen/progestin and testosterone users was 293 per 100,000 woman-years—substantially less than women receiving estrogen/progestin in the Women's Health Initiative study (380 per 100,000 woman-years) or the Million Women Study (521 per 100,000 woman-years). The breast cancer rate in testosterone users in this study was closest to that reported for users who never used hormone therapy in the latter study (283 per 100,000 woman-years), and their age-standardized rate was the same as for the general population in South Australia. Based on these findings, adding testosterone to traditional hormone therapy for postmenopausal women may not raise the risk of breast cancer and may even lower it, bringing the rates back to what they are in the general population that is not on hormone therapy. But more studies are needed. LATEST DATA ON TESTOSTERONE AND WOMEN: A recent study review by Dr. Rakibul Islam and his team was published in The Lancet in July 2019 and retrieved 46 reports of 36 randomized controlled trials comprising 8480 female participants. Their meta-analysis showed that testosterone significantly improved sexual function compared to a placebo or a comparator (e.g., estrogen with or without progesterone). It improved sexual desire, pleasure, arousal, responsiveness, and self-image, and it decreased sexual concerns and distress in postmenopausal women. A significant rise in the amount of LDL-cholesterol and reductions in total cholesterol, HDL-cholesterol, and triglycerides were seen with testosterone administered orally but not when administered non-orally (e.g., by transdermal patch or cream). An overall increase in weight was recorded with testosterone treatment. No effects of testosterone were reported for body composition, musculoskeletal variables, or cognitive measures, although the number of women who contributed data for these outcomes was small. Testosterone was associated with a significantly greater likelihood of reporting acne and hair growth, but no serious adverse events were recorded. TESTOSTERONE USE IN WOMEN IN THE UNITED STATES As previously mentioned, there is no FDA-approved testosterone product for women. Some doctors prescribe drugs for female patients by having them use low doses of products like Androgen, Testim, Axiron, Testopel, and Fortesta that are meant for male hypogonadism without following the product's label. Other doctors prescribe creams with low testosterone levels through compounding pharmacies. However, it is important to note that women and people with AFIB require significantly less testosterone, necessitating a much lower dose of medication compared to men. CONCLUSION In conclusion, low testosterone in women is a condition that is often overlooked and underdiagnosed. However, it can have significant impacts on a woman's quality of life, including decreased sex drive, fatigue, and mood changes. Fortunately, there are several treatment options available, including hormone replacement therapy, lifestyle changes, and medication. It is important for women to speak with their healthcare provider and get properly diagnosed and treated for low testosterone if necessary. By doing so, they can improve their overall health and well-being.   References: Effects of testosterone therapy for women: a systematic review and meta-analysis protocol.Syst Rev. 2019; 8: 19   Efficacy and safety of transdermal testosterone in postmenopausal women with hypoactive sexual desire disorder: a systematic review and meta-analysis. Fertil Steril. 2017; 107: 475-482

How can I find a clinic or lab near me to get my testosterone levels checked? Finding a clinic or lab near you to get your testosterone levels checked can be done by searching online directories like Yelp, Google Maps, or specific medical testing center websites like DiscountedLabs.com . You can also consult your primary care physician for recommendations on where to get this test done conveniently. You can buy a testosterone test without a doctor visit and insurance cheaply on Discounted Labs. We currently serve the following states: Alabama, Arkansas, California, Colorado, Connecticut, Florida, Georgia, Illinois, Indiana, Iowa (Des Moines), Kansas, Kentucky (Louisville & Lexington), Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Missouri, Montana (Great Falls), Nebraska (Omaha & Lincoln), Nevada, North Carolina, New Mexico, Ohio (Cleveland & Akron), Oklahoma (OKC), Oregon, Pennsylvania, South Carolina, Tennessee, Texas, Utah (Salt Lake City), Virginia, and Washington. Sign up for our newsletter. You will know when we start expanding to other states. We cannot serve NY, NJ, RI, and AZ. Click on this map and enter your zip code to locate a lab nearby. NOTE: If you don't see any locations, please clear your browser cache and try again. CLICK HERE TO BUY A TESTOSTERONE TEST NEAR YOU.   Understanding Testosterone Testing Testosterone is a vital hormone for men, playing an essential part in sex-related maturation and features. The testicles are primarily responsible for producing it, with small amounts coming from the adrenal glands as well. Testosterone levels naturally decline as you age, beginning around age 40. Decreased testosterone levels can cause various medical issues, such as erectile dysfunction, fatigue, low libido, reduced muscle mass and bone density loss. A testosterone test, also known as a male hypogonadism test, measures the amount of testosterone present in your blood sample to diagnose conditions related to low T levels. It’s important to understand what a testosterone test is and why it’s necessary so you know when you need one and how to interpret the results accurately. Knowing when it’s time for a test can help prevent serious health problems down the line due to undiagnosed or untreated conditions associated with abnormal hormone levels. If you have symptoms like fatigue, depression, or decreased sex drive that may be related to low T levels, then it may be time for a testosterone test. Other medical conditions, such as PCOS or hypogonadism, might necessitate consistent tracking of hormone levels through testing - especially if they are being managed with drugs that could have further implications later. Age-related recommendations vary but generally speaking, men over 50 should consider getting tested more regularly than younger individuals since their hormones tend to fluctuate more quickly at this stage in life due to natural aging processes taking place within their bodies Accuracy of results can be affected by various factors, such as sample collection timing (e.g., morning versus evening samples) and fasting state (pre- or post-meals). To ensure reliable outcomes, it is important to take these into consideration when undergoing a testosterone test. Being knowledgeable about the diverse assessments for testosterone assessment is key to preserving one's wellbeing, so it is essential to be aware of the assorted tests that are obtainable. With that in mind, let us explore why regular testosterone testing is important for maintaining optimal hormone levels. Why Testosterone Testing is Important Testing for testosterone is a critical element in managing and sustaining healthy hormone levels among males. Low testosterone, or “low T”, can lead to a variety of health issues that can affect quality of life. Regular testing helps identify any hormonal imbalances early on so they can be addressed promptly. Understanding the significance of keeping hormone levels in a healthy state is essential. Testosterone is an essential hormone for male physical characteristics, energy levels, moods and fertility; its absence can cause severe medical issues. It also influences energy levels and moods, as well as sperm production and fertility. Unchecked low testosterone levels can lead to a range of medical issues, such as ED, PCOS, weariness, despondency, uneasiness, diminished libido and barrenness. By monitoring testosterone levels, medical professionals can gain insight into the patient's overall health and identify potential causes of symptoms such as ED or PCOS, while also tracking treatment progress if therapy is being used. Tracking changes in hormones over time allows them to identify potential causes for symptoms such as ED or PCOS and monitor treatment progress if therapy is being used to address a related condition. Furthermore, regular testing ensures that the body has adequate levels of testosterone necessary for normal metabolic and reproductive functions. Regular testing for testosterone is essential to maintaining good health, as it can help detect and prevent potential problems associated with low T. Therefore, understanding when to get tested for testosterone levels is an important part of keeping your hormones balanced. When to Get Tested for Testosterone Testosterone testing is important for men to understand and stay on top of. It's especially essential to get tested if you have symptoms like reduced libido or energy, or a medical condition that may influence your hormones. Knowing when it's best to get tested for testosterone levels, especially after making lifestyle changes, can help you maintain healthy hormone levels and prevent any health risks associated with low T or determine if testosterone therapy may be necessary. Signs of a need for testosterone assessment may include impotence, tiredness, gloominess, reduced muscle mass/power, raised body fat levels, decreased bone density and hair loss - all of which should not be disregarded. If these symptoms are present, including changes in sexual function, lower sex drive, physical changes, and emotional changes, it is advisable to seek medical advice and have a blood test done to check for symptoms of low testosterone or high testosterone. Certain medical conditions, such as PCOS, adrenal gland disorders and type 2 diabetes, can lead to abnormal testosterone levels in men which may require regular monitoring. Your physician will advise you when the most suitable time to be examined is, depending on your particular requirements; therefore, make sure to adhere carefully to their counsel. Age-related recommendations also play an important role in deciding when to get tested for testosterone levels since natural production decreases with age, starting around 30 years old but at different rates depending on the person’s lifestyle habits and genetics. For those aged 18–70, it is suggested to get their testosterone levels checked every five years or sooner if they notice any alterations in physical capability or mental health. It is essential to consider individual circumstances when determining the necessity of a testosterone test, so consulting with your doctor or healthcare provider is recommended. The next heading will discuss different types of tests available for measuring testosterone levels in the body. Types Of Testosterone Tests Testosterone is a hormone found in both men and women, but it’s more prevalent in males. Understanding testosterone levels is critical for achieving and maintaining optimal health, as it influences muscle growth, bone density, sexual performance, fertility, energy levels and even mood. It plays an essential role in muscle growth, bone density, sexual performance, fertility, energy levels and even mood. That's why understanding testosterone testing is so important. Healthcare professionals rely on two reliable methods to measure one's total and free circulating serum concentration, namely immunoassays and liquid chromatography/mass spectrometry (LC/MS), with saliva tests and urine tests being the other available options. However, only the former two have been scientifically validated for clinical use. Measuring free testosterone can be accomplished using either immunoassay or LC/MS, but the latter is known to provide more precise results due to its capacity to detect lower hormone concentrations with greater accuracy than other methods. On the other hand, total testosterone and bioavailable testosterone measure all forms of circulating testosterone, including both free and bound types, respectively; however, they are also beneficial in determining how much active hormone is available within your body at any given moment as opposed to simply measuring overall amounts present in circulation. Testosterone tests are important for monitoring and diagnosing hormonal imbalances in men. Knowing the various testosterone tests accessible is vital to guaranteeing precise results from your blood test. Let's explore other methods of gauging hormone levels through blood testing. Types Of Blood Tests For Measuring Hormone Levels Blood tests are the go-to method for gauging hormone levels in the organism. Two of the most popular blood tests for measuring testosterone levels are immunoassays and LC/MS, with immunoassays being favored due to their convenience while LC/MS provides more precise results. Immunoassays have become widely used due to their ease, while LC/MS provides more accurate results, especially when detecting small changes over time. Immunoassays use antibodies to detect hormones in a sample of blood or other bodily fluid. The test measures total testosterone, which includes both free and bound forms of the hormone. Although this method is reasonably quick and affordable, it is susceptible to substances like steroids that could affect the outcome. Liquid chromatography/mass spectrometry (LC/MS) is a more precise technique that separates molecules based on size and electrical charge before analyzing them using mass spectrometry. This technique permits the quantification of free testosterone and its metabolites, such as DHT. It also has greater sensitivity than immunoassay, meaning it can detect smaller amounts of hormones present in the sample. However, this method is more expensive and takes longer to get results back from a laboratory setting than an immunoassay does. Accurately assessing hormone levels is best done through blood tests, which provide a comprehensive picture of an individual's health. Saliva and urine tests also offer valuable insights into hormonal imbalances, making them useful complementary tools for monitoring hormones. Saliva And Urine Tests For Measuring Hormone Levels Saliva and urine tests are two of the most commonly used methods for measuring hormone levels, including testosterone. Saliva testing has become increasingly widespread in recent times, due to its convenience and precision. Urine testing has been around longer but is not as accurate as saliva testing. Saliva Tests: Saliva tests measure free testosterone, which is the active form of testosterone circulating in your bloodstream. This type of test can be done at home with an at-home kit or by visiting a lab for collection. Saliva testing offers a more precise assessment than blood or urine tests, since it only measures the active hormones in your body. Urine-based measurements, which measure total testosterone levels (including both free and bound forms of the hormone circulating in your bloodstream), can provide insight into overall hormone levels. However, this method may not give you an accurate picture due to potential influences from external factors such as medications or lifestyle choices like stress or dieting that could affect how much free testosterone is available to perform its duties within cells and tissues throughout the body. Saliva tests, on the other hand, can measure levels of free testosterone and other sex hormones more accurately, making them a preferred method for assessing hormone levels in individuals with sexual problems or conditions that can affect SHBG levels. Therefore, it is important to consider all possibilities when assessing one's hormone levels using urine or saliva tests. Saliva and urine tests are both effective ways to measure hormone levels in the body, however, they each have their own pros and cons. For accurate results, one must take into account aspects like collection procedure, storage conditions and lab technique. Moving on from here, we will discuss these influencing factors in more detail. Factors Affecting Accuracy Of Results Accuracy of testosterone test results is essential for getting an accurate diagnosis and treatment plan. The accuracy of a testosterone test can be affected by many things, such as the type of sample used, the testing method (such as CLIA-certified clinical laboratory tests), changes in hormone levels that come with getting older, medical conditions like Polycystic Ovary Syndrome (PCOS), drugs taken before the test, and other lifestyle choices. The most widespread way to gauge testosterone concentrations is via serum or plasma specimens. These samples are collected by drawing blood from a vein in the arm or hand using a needle. For optimal accuracy, samples should be processed in a laboratory within 24 hours of collection. Immunoassays are typically employed as screening tests due to their affordability, but they possess lower precision than LC/MS, which is more reliable yet costlier. Saliva and urine tests are also available but these tend to have lower accuracy rates than serum or plasma tests because hormones can bind with proteins in saliva or become diluted in urine, making them harder to detect accurately. It is important to note that the accuracy of test results can also be affected by the testing laboratory used, as different labs may have varying levels of expertise and equipment. As men age, their adrenal glands produce smaller amounts of testosterone, leading to a gradual decline in total testosterone concentrations. Thus, it is advised that males over 40, especially older men, have their testosterone levels examined frequently, even if they are not showing any indications of low T such as erectile dysfunction or a decrease in body hair growth; doing so can help to avert potential harm before it's too late. Regularly checking testosterone levels for older men is crucial in avoiding potential damage caused by the gradual decline in total testosterone concentrations. FAQs in Relation to Testosterone Test Near Me Where can I get my testosterone levels checked? You can get your testosterone levels checked without a doctor visit by ordering an at-home blood test online. These tests offer a handy solution, enabling you to take your sample in the privacy of your own home and send it away for analysis. Results typically arrive within days, giving you accurate information about hormone levels that could be impacting health and fitness goals. With access to this data, individuals can make informed decisions about their health care needs with confidence. How much does testosterone level test cost? The cost of a testosterone level test depends on the type and complexity of the test. Generally, basic tests range from $50 to $100, while more complex tests can cost as much as several hundred dollars. Most insurance policies will offer some form of reimbursement for the expenses associated with these blood tests. Additionally, many online testing services offer discounted prices for those who order multiple tests at once. Discounted Labs has the most affordable testosterone test in the United States. Can I get a testosterone test without a doctor's referral? Yes, you can get a testosterone test without a doctor's referral. Most online blood testing services provide convenient access to lab tests with no need for a physician's order or visit. A simple online platform and payment process make it easy to access lab tests without a doctor's prescription. Tests are then sent directly to the laboratory, where results are available within days, allowing individuals to monitor their health quickly and conveniently from home. What doctor should I see for testosterone? For a comprehensive assessment of your health, including any underlying causes that may be contributing to changes in your testosterone levels, an endocrinologist is the best professional to consult with. An endocrinologist specializes in hormone-related conditions and can provide a comprehensive assessment of your health, including any underlying causes that may be contributing to changes in your testosterone levels. An endocrinologist can offer advice regarding the most effective way to address any hormonal discrepancies that may be present. Conclusion In conclusion, it is important to understand the different types of testosterone tests and when to get tested for accurate results. Blood spot finger prick tests are not recommended as they are not always reliable. At-home test kits should also be avoided due to their inaccuracy in measuring testosterone levels accurately. If you're looking for a reliable and convenient way of testing your testosterone levels, look no further than our online blood test near me, which can provide an easy solution without needing a doctor visit. Take control of your health today and get the testosterone test you need quickly, conveniently, and affordably with DiscountedLabs.com - no doctor visit required!

Decoding MCHC Blood Test Results: A Comprehensive Guide An MCHC blood test is a key part of a complete blood count (CBC). It gives important details about a person's health. This test measures the mean corpuscular hemoglobin concentration in red blood cells. This measurement helps the body carry oxygen effectively. The MCH blood test, also known as the hemoglobin test, is part of the CBC. A CBC is a common blood test that checks different parts of your blood. These parts include red blood cells, white blood cells, and platelets. The MCH value tells us the total amount of hemoglobin in the blood. This helps us understand the average amount of hemoglobin in each red blood cell. In this blog post, we will talk about why MCHC levels are important. We will also explore the health conditions that these levels can indicate. The MCH test is one of several tests used in RBC indices. These tests look at different features and roles of red blood cells. MCH is a crucial measure for seeing how well oxygen moves in the body. A change in MCH or other RBC indices might point to a blood disorder known as anemia. As you read this, you will learn about low and high MCHC blood test values. Anemia and low vitamin levels are associated with these values. We will examine the underlying causes of these issues and identify the symptoms to be aware of. We will also talk about how doctors find these problems using CBC tests. Lastly, we will explain how to prepare for this blood test. Lastly, we will talk about how to help people with unbalanced MCHC levels. You might need to change your lifestyle and use medical treatments. It is important to check your health with regular tests. When you see your blood test results, you can take steps to stay healthy. What is the MCH blood test? The MCH blood test stands for mean corpuscular hemoglobin. This test looks at the average amount of hemoglobin in your red blood cells. Hemoglobin is a protein in those cells. Its main job is to carry oxygen around your body. You can often see the MCH value in a complete blood count (CBC). This value can help find some health issues, such as anemia and other blood problems. A low MCH value might mean you have iron deficiency anemia. A high MCH value might show you don't have enough vitamin B12 or folate. Keep in mind that the MCH value is just one part of your health. A healthcare professional should look at it along with other tests and symptoms. If you're worried about MCH or your health, see a doctor. A normal range for MCH levels is 32 to 36 grams per deciliter (g/dL) or 320 to 360 grams per liter (g/L). This shows that there are around 26 to 33 picograms (pg) of hemoglobin in each red blood cell (RBC). Hemoglobin is a kind of protein. Its main job is to carry oxygen from the lungs to the body. After delivering the oxygen, hemoglobin takes carbon dioxide back to the lungs. MCH levels tell us how much hemoglobin is in each red blood cell. These levels are measured in picograms (pg) for each red blood cell. The MCH number is very important. It helps doctors identify different types of anemia. Anemia happens when there are fewer red blood cells or not enough hemoglobin. If the MCH level is high, it may show that a person has macrocytic anemia. This means the red blood cells are larger than usual. A low amount of folic acid or vitamin B12 can cause this issue. If the MCH level is low, it might mean you have microcytic anemia. This condition occurs when the red blood cells in your body are smaller than normal. Long-term health issues or iron deficiency anemia are typically the causes. MCH does not usually work alone to find these problems. It is one of several tests. These tests include MCV, which means mean corpuscular volume, and MCHC, which means mean corpuscular hemoglobin concentration. When we combine these tests, they give us a clearer picture of the health of your red blood cells. Components of CBC Panel A CBC panel includes several tests. These tests give information about your blood, such as: The hemoglobin level tells you how much of this important protein is in your blood. Hematocrit tells you how much of your blood is made up of red blood cells. It looks at the amount of red blood cells compared to the total plasma in your blood. The red blood cell count (RBC) shows how many red blood cells are in your blood. These red blood cells are important. They carry oxygen throughout your body. MCHC tells us the average amount of hemoglobin in each red blood cell. It is shown as a concentration value. Importance of Hemoglobin Red blood cells have hemoglobin in them. Hemoglobin takes in oxygen and sends it to the body's tissues. It also helps get rid of carbon dioxide, which our bodies produce as waste. Keeping the level of hemoglobin just right is very important. This ensures that our bodies receive enough oxygen and can remove waste properly. If we have too much or too little hemoglobin, it can lead to health problems. These issues can range from minor ones, such as fatigue, to more serious ones, such as organ damage due to low oxygen levels. Hemoglobin is what gives red blood cells their red color. That is why it's important to check it during a CBC panel. Understanding the MCHC blood test is key for a complete CBC panel. This test gives us information about hemoglobin. It helps us see low levels, which can suggest anemia. Low MCH levels might mean iron deficiency anemia or normochromic anemia. Low MCH levels can be caused by various factors. Not getting enough iron could lead to this. A genetic disorder called thalassemia can also cause low levels. Low MCH may indicate a health issue that needs more tests or treatment, such as aplastic anemia. Aplastic anemia is a common type of anemia that occurs when there isn't enough iron to make hemoglobin. Abnormal MCH levels can be a concern, but they are not always serious. However, they do need attention. You should treat problems with MCH levels, such as anemia, thyroid issues, or not getting enough nutrients, to maintain your health. There are several types of anemia that can lower MCH levels. One type is microcytic anemia. This occurs when blood cells are too small to carry enough hemoglobin. It can happen because of a poor diet or missing key nutrients. Also, losing blood suddenly can decrease MCH levels. An MCV blood test means mean corpuscular volume. It measures the average size of red blood cells in your blood. This test is part of a complete blood count, also known as CBC. Doctors use this test to find health issues. These issues can include anemia, vitamin deficiencies, liver disease, and some bone marrow disorders. Other tests, like mean corpuscular hemoglobin (MCH), give more details about red blood cells. This information helps to understand other blood tests better. When someone's MCV blood test results are high, it may mean they have macrocytic anemia or a vitamin B12 problem. A low MCV level might show microcytic anemia or iron deficiency. Checking MCV levels can give important clues about a person's health. This information helps doctors pick the right treatment. It's important to speak with a doctor to understand your MCV blood test results. They can help you decide what to do next, like getting more tests for iron deficiency or other health problems. MCHC Low Values and Anemia Low MCHC values can mean a person has anemia. Anemia is when the body lacks enough healthy red blood cells. These cells are very important because they carry oxygen to your body's tissues. There are several reasons why MCHC levels may be low. A common cause is iron deficiency. Some genetic conditions, like thalassemia, can also result in low MCHC levels. Causes of Low MCHC Values Iron Deficiency: Iron is key for making hemoglobin. If you do not get enough iron or your body struggles to absorb it, your hemoglobin levels may drop. This can result in anemia. Thalassemia: This is a blood disorder that is passed down from parents. It changes how the body makes normal hemoglobin. This can lead to unusual red blood cells, causing anemia. Blood Loss: A large loss of blood from an injury or surgery can lower the count of red blood cells. A drop in red blood cells can affect MCHC values. Hemolytic Anemia: This type of anemia happens when the body breaks down red blood cells faster than it produces them. Autoimmune diseases or other problems can cause this. Symptoms Associated with Low MCHC Blood Test Results Low MCHC values can lead to several symptoms. You might feel weak, tired, or dizzy. Some people also have difficulty breathing. These feelings happen when your body doesn't get enough oxygen from your blood. Other signs to watch for include pale skin, cold hands and feet, and heavy or unusual menstrual bleeding. If you feel any of these symptoms, it's important to see a doctor. They may tell you that you have anemia. Knowing the symptoms of anemia can help you spot and manage health issues. To understand why your MCHC levels are low, you might need to take more tests. You can look online for lab panels that are cheap. A complete iron panel shows how much iron you have in your body. This helps you understand your low MCHC values more clearly. With this information, you can select the best way to stay healthy. High MCHC Values and Vitamin Deficiencies Some vitamin shortages, like low vitamin B-12 and folate, can lead to high MCHC blood test levels in a blood test. This can make the count of red blood cells appear to have low MCH levels. Regular tests can help find these problems early. This helps prevent issues with how red blood cells carry oxygen. High MCH levels might also point to macrocytic anemia. This means the red blood cells are larger than normal and have more hemoglobin. A few factors can cause this. These include not getting enough vitamin B-12, low folate, liver disease, and alcoholism. Sometimes, high cholesterol can also make high MCHC levels look high. Causes of High MCHC Values Vitamin B-12 deficiency: Vitamin B-12 is important for making healthy red blood cells. If you do not get enough B-12, your red blood cells can become larger and hold more hemoglobin. This may cause high MCHC levels. Common reasons for this deficiency include a lack of B-12 in your diet, digestion problems, or pernicious anemia. Folate deficiency: Folate is necessary to create red blood cells the right way. A shortage of folate can also result in larger red blood cells with more hemoglobin. This can also raise MCHC levels. A poor diet or troubles with absorption can lead to low folate levels. Liver disease: Issues like liver disease, including cirrhosis or hepatitis, can raise MCHC levels. These liver conditions affect how the body produces healthy red blood cells. Symptoms Associated with High MCH Blood Test Levels If your mean corpuscular hemoglobin concentration (MCH) is high because of low vitamins or other health issues, you might notice several symptoms, such as: Feeling very tired and weak Trouble breathing Dizziness or light-headedness Skin looks pale. Heart is beating quickly. To stay healthy, it's a good idea to check your MCHC levels often. If you notice pale skin and a fast heartbeat, it might mean your MCHC levels are high, and you could need more vitamins. If you experience these signs, you should go to a doctor. They can do more tests and recommend a treatment. You can visit websites like DiscountedLabs.com. They have affordable lab tests in many cities across the U.S. You do not need to see a doctor before getting tested. It is important to stay active regarding your health. Checking the levels of important things in your body can help prevent serious issues from low oxygen in your red blood cells. This form allows patients to ask questions about their lab tests. High MCHC values could mean that your body is missing some vitamins. It's essential to pay attention to any symptoms you may feel. A CBC test can help identify any issues. This test will give you a clearer picture of your health. Treatment Options for MCHC Low and High Levels Fixing problems with MCHC levels is important for your health. It ensures that your red blood cells can carry enough oxygen. How you treat this issue depends on whether your MCHC levels are too high or too low. A simple way to improve this is by changing your lifestyle and taking supplements. Sometimes, you may need to see a doctor for help with your MCHC levels. Lifestyle Changes for Maintaining Healthy MCHC Levels Changing what you eat can help you maintain healthy MCHC levels. It is important to choose foods high in iron, vitamin B-12, and folate. These nutrients help your red blood cells stay strong. Here are some good examples of these healthy foods: Iron: You can find it in things like lean meat, chicken, fish, beans, lentils, and tofu. Vitamin B-12: You will find it in eggs, milk, cheese, and cereals that have added nutrients. Folate: You can get it from dark green vegetables, like spinach and kale, as well as from citrus fruits, such as oranges. Regular exercise can make blood flow better. It also helps your body make new red blood cells. Medical Interventions for Extreme MCH Blood Test Imbalances If changing your lifestyle does not fix low MCHC levels, there might be a health issue that needs attention. In some cases, blood transfusions can be helpful. A blood transfusion gives you healthy red blood cells from a donor. This process helps raise the oxygen level that your red blood cells can carry. For people with genetic issues like thalassemia or sickle cell anemia, better treatments are very important. One choice is iron chelation therapy. This therapy helps take extra iron out of the body. There are also gene-editing therapies. These treatments try to fix the genetic problems that cause these diseases. If you think your MCHC levels are not normal, it's smart to talk to a healthcare worker. They can give you advice that is right for you and your health history. It is important to know the treatment options for high MCHC levels. If you feel you need help, you should talk to a doctor. Regular health check-ups can help you keep track of your MCHC levels. Testing often can catch any problems early, before they become serious. Frequently Asked Questions: MCHC Blood Test What level of MCHC is concerning? The lab shows the reference range for normal MCHC blood test levels. Usually, if your MCHC level is under 31 g/dL or over 37 g/dL, it is seen as unusual. This might mean you need more tests. It's a good idea to talk to a healthcare professional. They can help you understand your results better. Should I be worried if I have a low MCHC value? Low MCHC levels can show that you may have anemia. This is often the case with a type called hypochromic microcytic anemia. While this can be worrying, it's important to find the underlying cause. You need to have more tests and speak to a healthcare provider. The treatment you need will depend on the cause of the issue. It might involve changing your diet or receiving medical care. What affects the MCH blood test? Your MCHC levels can change for several reasons. Not having enough iron, vitamin B12, or folate can lower these levels. Chronic diseases, like kidney disease or cancer, can affect them too. Genetic conditions such as sickle cell disease or thalassemia are significant factors as well. Medications that change how red blood cells are made or broken down, including some chemotherapy drugs, play a role. Also, what you eat and how you exercise can impact your MCHC levels. Conclusion The MCHC test does not directly diagnose anemia or vitamin deficiencies. It's more helpful when done alongside other tests, like the CBC. This combination can help identify and address health problems. Regular testing is good for keeping track of your health. It can help detect changes before they turn into serious issues. Knowing your MCHC levels is important for your well-being, so make sure to get tested regularly. Take care of your health using discountedlabs.com. You can get a low-cost MCHC blood test today. You don't need to visit a doctor for it. You can also purchase a CBC test right now. Sources:  [1] MCHC Blood Test: What It Is, Purpose, and Normal Range [2] What Does a Low or High MCHC Mean in a Blood Test? [3] MCHC Test: Meaning, Procedure, and Results [4] MCHC Blood Test: What High and Low Levels Mean [5] Low MCHC: Causes, Symptoms, and Treatment

TRT Blood Work Tests For Monitoring Men on Testosterone Therapy Before undergoing testosterone replacement therapy (TRT), it’s vital to obtain a number of blood tests, which require a blood sample. The main blood tests to measure are total and free testosterone, hematocrit, PSA, estradiol, HDL cholesterol and others. Pre-treatment testing provides doctors with baseline values to diagnose hypogonadism (low testosterone) and assess overall health. Baseline tests are also conducted during TRT as well, ensuring that doctors can adjust TRT dose and catch side effects before they become an issue. Hematocrit Test PSA Test Estradiol Test Blood Pressure Estimated Glomerular Filtration Rate eGFR Liver Enzymes Test TSH Test Free T3 Test Total Testosterone Test Free Testosterone Test Ferritin Test HDL Cholesterol Test Click here for the Pre- TRT panel and the TRT panel (after 6-8 weeks on TRT) But do you know why these tests are needed or what they mean? Below, you’ll find some of the main blood tests that have been shown to be affected by TRT, so doctors measure them before and during therapy to prevent or manage side effects: Understanding Testosterone Blood Tests A testosterone blood test is a crucial diagnostic tool used to measure the level of testosterone in your blood. Testosterone, produced by the adrenal glands and gonads (testes in men and ovaries in women), plays a vital role in the development and maintenance of male reproductive tissues, bone density, and muscle mass. This test is commonly employed to diagnose and monitor conditions related to abnormal testosterone levels, such as hypogonadism (low testosterone) and hyperandrogenism (high androgen levels). There are several types of testosterone blood tests, each serving a unique purpose. The total testosterone blood test measures the overall amount of testosterone in your blood, including both bound and free testosterone. The free testosterone test measures the testosterone that is not bound to proteins in the blood, making it readily available to the body’s tissues. Additionally, the bioavailable testosterone test measures the testosterone that is available to the body’s tissues and is not bound to sex hormone-binding globulin (SHBG). Understanding these different tests helps in accurately diagnosing and managing conditions related to testosterone levels. Why Monitor Testosterone Levels on TRT? Testosterone replacement therapy (TRT) is a medical treatment designed to increase testosterone levels in individuals with hypogonadism. Monitoring testosterone levels on TRT is essential to ensure the treatment’s effectiveness and safety. Here are some key reasons why monitoring testosterone levels on TRT is crucial: Ensuring Normal Testosterone Levels: The primary goal of TRT is to elevate testosterone levels to within the normal range. Regular monitoring helps ensure that the treatment is effective and that testosterone levels are neither too high nor too low. Adjusting Dosage: Monitoring testosterone levels allows healthcare providers to adjust the TRT dosage as needed, ensuring optimal treatment outcomes. Identifying Side Effects: TRT can cause side effects such as acne, hair loss, and mood changes. Regular monitoring helps healthcare providers identify these side effects early and adjust the treatment plan accordingly. Monitoring Long-term Effects: TRT can have long-term effects on the body, including changes in bone density and cardiovascular health. Regular monitoring helps healthcare providers track these changes and make necessary adjustments to the treatment plan. By keeping a close eye on testosterone levels, healthcare providers can ensure that TRT is both effective and safe for the patient. Hematocrit Test Hematocrit refers to the proportion or percentage of red blood cells present in your total blood volume. Your red blood cells are responsible for transporting oxygen and nutrients throughout your body. Without enough red blood cells (a condition known as anemia), your body suffers from oxygen and nutrient deprivation. On the flip side, too many red blood cells cause high hematocrit that can turn your blood into a thick slurry that can seriously affect your circulation. A normal hematocrit for an adult male is anywhere from 42 to 54%. If your hematocrit results are lower than 41%, it means you have low proportion of red blood cells. Over 55%, and you have too many. One of the primary side effects of TRT is the production of too many red blood cells, leading to high hematocrit. High hematocrit can be lowered by blood donation or therapeutic phlebotomies (ordered by your doctor if you are not allowed to donate blood at a blood bank due to exclusion criteria). Just be careful: Do not donate blood more frequently than every 2 months since this can deplete your iron stores and make you tired. This test is included in CBC (chemistries and blood count) panel.   PSA Test Prostate-specific antigen, or PSA, is a protein that is produced in your prostate gland. It's designed to liquefy semen, which is necessary for the free swimming of sperm in ejaculate. It may also help to dissolve the cervical mucus to allow the sperm to enter the uterus for the purposes of impregnation. Normal PSA levels for men under 40 range between 0 and 2 ng/mL, while PSA levels for men older may raise slowly. A PSA test helps to detect extra-high levels of this protein. High PSA levels are the result of disruptions of the cellular structure of the prostate gland, which can be caused by a number of diseases--including cancer or an infection. Benign prostate hyperplasia, urinary retention, and prostatitis can be the cause of high PSA, but your doctor will want to monitor your PSA levels just to be sure the problem isn't a serious one. If PSA levels are high, your doctor may recommend a prostate exam or even a biopsy to determine the cause of your elevated PSA levels. TRT is contraindicated for men with PSA greater or equal than 4. Estradiol Test Estradiol is the primary female sex hormone, but did you know that the male body produces it from testosterone? It is produced in fat and liver cells from testosterone via the aromatase enzyme. Due to several factors like fat content, liver disease, medication effects and genetics, some men may produce more estradiol from testosterone than other men. New information has shown that men require a special estradiol test called sensitive estradiol test. The regular test used for women may overestimate estradiol in men due to interference of inflammatory markers like C-Reactive Protein (CRP). For the average man, estradiol levels should remain lower than 50 pg/mL, although there is little evidence of what the top of the estradiol test is in men who do not have low testosterone. If estradiol levels are higher than 50 and you start showing symptoms of high estradiol (gland growth under nipples, too much water retention), it may be necessary to take an estrogen blocker (aromatase inhibitor) . However, taking aromatase inhibitor like anastrozole should be done with careful monitoring of sensitive estradiol blood test since overdosing can cause health issues in men. A few of the reported effects of low estradiol levels include: joint pain, eye fatigue, loss of erections, limited sensitivity in the penis, sleepiness, and excessive urination. Long term low estradiol can decrease bone density. A few of the reported effects of high estradiol levels (in the presence of low testosterone) include: soft erections, water retention, excessive sweating, insomnia, bloating, hot flushes, brain fog, and high blood pressure. Blood Pressure The term "blood pressure" refers to the pressure in your arteries during the beating of your heart. There are two numbers: 1) The top number, or systolic, tells you the pressure in your arteries when the muscles of your heart contract. 2) The bottom number, or diastolic, tells you the pressure in your arteries when your heart relaxes and refills with blood in the pause between heartbeats. Healthy blood pressure is lower than 120/80. If your blood pressure rises anywhere from 121/81 to 139/89, you are pre-hypertensive. Crack 140/90, and you suffer from hypertension. Anyone over 180/100 is in serious hypertensive crisis. TRT can increase water retention, sodium uptake and hematocrit is some men, factors that can increase blood pressure. If your blood pressure rises too much, it can place excess strain on your blood vessels and potentially cause a crack. Should the blood vessels crack, the resulting clotting (your body's attempt to stop internal bleeding) can interfere with healthy blood flow--potentially leading to heart attacks, strokes, peripheral arterial disease, and other cardiovascular problems. Estimated Glomerular Filtration Rate eGFR Your glomerular filtration rate (GFR) is an indication of your kidney function. The higher your GFR, the more blood passes through the glomeruli (the filters in your kidneys that remove waste from your blood) every minute. A healthy GFR is anywhere from 90 to 120 mL/min/1.73 m2. Senior citizens will often have lower GFR levels, due to the fact that kidney function decreases with age. Note: It's important to understand that each lab has its own measurements, so what is "healthy" to some may be low with others. If your GFR drops below 60 and remains at that low level for more than 3 months, it's an indication of chronic kidney disease. Liver Enzymes Test Your liver is responsible for a number of important functions, such as breaking down nutrients, producing the proteins that clot your blood, and eliminating toxins. The enzymes produced by your liver are responsible for carrying out these functions. However, if the liver suffers damage, those enzymes tend to leak into your bloodstream. High levels of liver enzymes are a good indicator that your liver has been damaged ALT and AST are the two most common liver enzymes. AST should be anywhere from 10 to 40 units per liter of blood, and ALT should be from 7 to 56 units in every liter of blood. Be aware that exercise may increase these two enzymes in a non-clinically significant way. Only oral testosterone replacement has been shown to increase liver enzymes. TSH Test Thyroid-stimulating hormone, or TSH, is a hormone produced by your pituitary glands in order to stimulate your thyroid gland to produce T3 and T4 hormones. These thyroid hormones play a role in your body's metabolic function. Normal TSH levels should be between 0.5 and 3.5 U/ml (different guidelines show different upper TSH levels). Many educated doctors test for free T3 and free T4 (the unbound thyroid hormones) when TSH is over 3 since they believe this will provide a better picture of thyroid health. If TSH levels are low, it's an indication of hyperthyroidism. If TSH levels are very high, it's an indication of hypothyroidism. Free T3 Test Free T3 refers to unbound T3 (thyroid) hormone in your bloodstream. T3 is the more important of the thyroid hormones, but it can only be produced from T4. This means your body needs to produce T4 then turn it into T3. Once the T3 is unbound from the protein molecules, it can then be used by your body to stimulate metabolic function in all your cells. Normal Free T3 levels are anywhere from 230 to 620 pg/d. If free T3 is low, your doctor may test for thyroid antibodies to ensure that you do not have an autoimmune disease called Hashimoto's. Total Testosterone Test Total testosterone test measures refer to all of the testosterone circulating in your body. Some testosterone circulates freely, while some is bound to protein molecules. The whole point of TRT is to increase your testosterone levels. A normal testosterone range is anywhere from 350 to 1070 ng/dL. Low testosterone can cause low mood, sex drive, fatigue and other symptoms. In some men, too much testosterone in the body can lead to excessive estradiol, acne, oily skin, hair loss, testicular shrinking, and increased blood viscosity due to high red blood cells. Free Testosterone Test Free testosterone refers to the testosterone circulating in your body that is NOT bound to protein molecules like albumin and sex hormone binding globulin. It is believed that your body is more easily able to use free testosterone. It usually runs at about 2 percent or higher of total testosterone. Testosterone Test Results and Interpretation Testosterone test results are typically reported in nanograms per deciliter (ng/dL). The normal range for testosterone levels varies depending on age, sex, and the laboratory performing the test. Here are some general guidelines for interpreting testosterone test results: Normal Testosterone Levels in Adult Men: 300-1,000 ng/dL Normal Testosterone Levels in Adult Women: 15-70 ng/dL Low Testosterone Levels: Less than 300 ng/dL in men or less than 15 ng/dL in women High Testosterone Levels: Greater than 1,000 ng/dL in men or greater than 70 ng/dL in women It’s important to note that testosterone levels can fluctuate throughout the day and may be influenced by various factors such as sleep, stress, and exercise. Therefore, a single testosterone test result may not provide a complete picture of an individual’s overall testosterone levels. Healthcare providers may recommend repeat testing to confirm the results and monitor changes in testosterone levels over time. Understanding your testosterone test results and their implications can help you and your healthcare provider make informed decisions about your treatment plan. Ferritin Test Ferritin is a protein that is responsible for storing iron and releasing it when your body needs to produce red blood cells. If you suffer from an iron deficiency, your ferritin level are likely to be low. Ferritin levels also fall when you give blood (a common method of lowering hematocrit). Normal ferritin levels for men is anywhere from 30 to 300 ng/mL. However, if ferritin levels are too low (after a blood donation), your body is unable to store iron, meaning it will not be able to produce new red blood cells. If you are considering donating blood to lower your hematocrit, it's a good idea to check your ferritin levels first. Your body needs enough of this protein to reproduce the red blood cells you are donating HDL Cholesterol Test High density lipoprotein, also known as HDL cholesterol, is the "good" type of cholesterol. It's responsible for counteracting the effects of low-density lipoprotein, or LDL cholesterol. Low HDL and high LDL may lead to a wide range of cardiovascular problems, including blocked arteries, stroke, heart attack, and peripheral arterial disease. According to experts, even a 5 mg/dL decrease in HDL cholesterol can increase your risk of coronary heart disease by as much as 25% Normal HDL cholesterol levels are anything above 40 mg/dL. Unfortunately, decreased HDL is a known side effect of TRT in some men using higher testosterone doses. Your doctor will monitor HDL cholesterol via a lipid panel in order to ensure that you are not at risk for heart disease. Educate yourself about testosterone replacement side effects 

High hematocrit levels, which measure the percentage of red blood cells in the blood, can be signs of several underlying health conditions and they are also a common side effect of testosterone replacement therapy (TRT). High hematocrit levels can increase the risk of developing blood clots, strokes, and other serious complications, especially for those with an underlying condition. Low red blood cell levels, also known as low hematocrit levels, can indicate conditions such as anemia, while high red blood cell levels often signal dehydration and could indicate other conditions, such as polycythemia, increasing a person’s chance of developing blood clots or experiencing blood loss. We will review the different ways to lower the hematocrit and the number of red blood cells on TRT. How to Lower the High Hematocrit Caused by Testosterone Replacement Therapy (TRT) Testosterone replacement therapy (TRT) is one of the most effective ways to combat low testosterone levels, but it's vital that you understand the risks associated with the treatment. As with any form of hormone replacement therapy, there are a few downsides to receiving regular injections of testosterone. One of the main TRT side effects is increased hematocrit, also known as erythrocytosis, which can be a sign of androgen deficiency. This article will explain why this happens, the potential long-term health consequences, and how to prevent or manage this issue. Since abnormally high hematocrit values can pose serious health problems, this article will analyze the correlation between testosterone therapy and high hematocrit. TRT, sleep apnea, smoking, and red blood cell production are contributing factors that can cause high hematocrit that can increase cardiovascular risks if not properly managed. This article explains the basics of how to manage high hematocrit while using testosterone therapy. What is hematocrit? There are several standard ways to measure red blood cells: hematocrit, hemoglobin, and RBC (red blood cell count). All of these are related, and doctors will usually look at two or more. Hematocrit, also referred to as the proportion of red blood cells, is a measurement of how much of a person's blood is made up of red blood cells, also known as whole blood. Hemoglobin, on the other hand, is a density or concentration measurement and is expressed in grams per liter or deciliter. (Hemoglobin is, if you will recall from your high school biology, the iron-based protein that transports oxygen.) RBC is a simple count and is usually expressed as the number of million red blood cells that you have per microliter. Usually, hematocrit is three times the amount of hemoglobin and can be measured through a simple blood sample test. What are the normal ranges for hematocrit?  Normal levels of hematocrit for men range from 41% to 50%. normal level for women is 36% to 48%. Why does TRT increase hematocrit? Erythrocytosis is a medical condition that appears when the body makes too many red blood cells. RBCs are responsible for transporting oxygen to organs and tissues. When there are too many, the blood can become too thick and cause cardiovascular complications. There are two types of erythrocytosis: primary and secondary. Problems with the bone marrow, such as bone marrow disease, are typically the cause of primary erythrocytosis. RBCs are made in the bone marrow, and something might trigger an increase in their production. Certain diseases or medications, such as testosterone replacement therapy, can cause secondary erythrocytosis. Some studies concluded that testosterone reduces hepcidin (a hepatic hormone), which is related to iron absorption pathways. When hepcidin is reduced, erythrocytosis is increased [1] An increase in hemoglobin (Hb) and hematocrit (Hct) is indicative of this medical condition. When the Hb is higher than 18.5 g/dL and the Hct is higher than 52% in men, the patient suffers from erythrocytosis.   What are the risks of high hematocrit? One of the primary risks of testosterone that you need to be aware of is called polycythemia or erythrocytosis. This is a condition where your body produces too many red blood cells, also known as high hematocrit levels or secondary polycythemia. Hematocrit refers to the percent of red blood cell content in your blood, also known as Hct levels. If your hemocrit levels rise, your blood will become too thick or viscous. This can, in turn, make it more likely that you will develop strokes, heart attacks, and clotting events. Polycythemia is serious and potentially life-threatening if untreated. Since the RBC count is too high in people with erythrocytosis, the blood viscosity also increases, which can lead to various potentially life-threatening medical issues such as venous thromboembolism. This essentially means that tiny blood clots separate from their original source and travel through veins and capillaries, causing blockages that result in stroke, myocardial infarction, or other complications related to reduced blood flow and blood volume. Individuals with high hematocrit levels may also be at risk for conditions such as polycythemia vera, a bone marrow disease that causes an abnormal increase in red blood cells and can lead to symptoms of polycythemia vera such as headache, dizziness, and fatigue. Other potential risks include congenital heart disease, exposure to high altitudes, and reactions to blood transfusions. It can be quite stressful for a man who has finally gotten on TRT, feels better, and then finds out that his hemoglobin is high. Of course, he can always lower his testosterone dosage to try to solve the problem, but this may not be a solution that either doctor or patient wants to pursue. Many men have found that their erectile dysfunction is greatly helped and/or morning erections and libido have returned. The last thing they want to do is lower their dose. So why even worry about a high hemoglobin or RBC count? What’s a few extra red blood cells anyway? Unfortunately, high hemoglobin (or RBCs) is a risk factor for ischemic stroke, i.e., the standard kind of stroke where there is a loss of blood supply to tissues such that permanent damage is usually incurred. [2] Of course, a stroke can be a life-changing (or life-ending) event and should be avoided at all costs. There is also a longer-term risk: elevated hemoglobin could lead to unhealthy iron store levels, which are associated with heart disease and dementia. Iron in tissues can lead to oxidative damage. Just look at what some recent studies have concluded: “Low and high hemoglobin concentrations in older persons are associated with a lower level of cognitive function in old age, particularly in semantic memory and perceptual speed.” [3] “In older persons without dementia, both lower and higher hemoglobin levels are associated with an increased hazard for developing AD [Alzheimer’s Disease] and more rapid cognitive decline.” [4] Can hematocrit stabilize in men on TRT? Hematocrit may stabilize after long-term testosterone replacement. Although there is only one study done in mice, it may explain why hematocrit may eventually decrease and stabilize in men on TRT. There seems to be an adaptive mechanism that makes red blood cell indices change while hematocrit stabilizes. In some men, red blood cell indices (MCV and MCHC) start changing after starting TRT as a way for the body to compensate for the extra production of red blood cells. There are three red blood cell indices: mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC). They are measured by a machine, and their values come from other measurements on a CBC panel. The MCV shows the size of the red blood cells. The MCH value is the amount of hemoglobin in an average red blood cell. The MCHC measures the concentration of hemoglobin in an average red blood cell. [5] Another study that followed frequent blood donors found a reduction in ferritin in them, created as a way for the body to increase iron absorption in the presence of lower hematocrit. Ferritin and hematocrit stabilized after five donations.[6] How to Lower High Hematocrit on TRT Some physicians and TRT guidelines believe that the best way to lower hematocrit is to stop TRT. But stopping TRT can have negative consequences in the quality of life, as men who do so tend to stay hypogonadal for months, and most do not return to “normal levels.”. Fortunately, there are several ways to decrease high hematocrit and also potentially prevent it from happening. Give Blood. This is a time-proven technique for men on testosterone therapy to lower their hemoglobin levels. And you are helping out someone else while you’re doing it! Every unit of blood donated can decrease hematocrit by 3 points, which is equivalent to one pint of blood. However, be careful not to donate more frequently than every 2.5 months, as the Red Cross advises, to prevent losing too much iron and ferritin, which can cause fatigue in men using testosterone therapy. You can check your iron and ferritin levels with this iron blood test. It's recommended that you donate when you are in the 51–52 hematocrit range. However, some organizations (like the Red Cross) will reject blood with a hematocrit higher than 53%, so it is good to avoid that high hematocrit level if you want to donate blood. Men who are rejected from blood donations because of high hematocrit can still give blood if their physicians call in an order for a therapeutic phlebotomy at the local blood center.   Lower Your TRT Dose. If you have high hemoglobin or hematocrit from testosterone therapy, then your doctor may require you to lower your dose. This is not always a bad thing, as some men are actually taking more testosterone than they actually need, which can lead to side effects in both the long and short term.   Drink Water. It is important to remember that hemoglobin is very dependent on your hydration levels. If you were dehydrated when you had your blood drawn, this could have made things worse. If you think you were dehydrated, discuss a retest with your doctor.   Treat Thyroid Issues. Hypothyroidism (low thyroid function) can lower your RBC counts, and hyperthyroidism (high thyroid function) can raise them, too. If you haven’t checked your thyroid function lately, this might be wise. And don’t forget to get a full thyroid panel, including thyroid antibodies, if you can afford it. [10]   Consider transdermal (topical) or oral testosterone. One research summary stated that topical testosterone creams or gels increase hematocrit, in general, less than intramuscular testosterone injections: “Intramuscular testosterone is the only form that significantly increases hematocrit above normal levels. However, it does so strongly, with up to a 6% change from baseline. The runner-up is testosterone gel, with an average increase of 2.5% over baseline levels.” [7]. Therefore, if you are on intramuscular injections and struggling with high hematocrit or hemoglobin, going on topicals may help a little. Discuss with your physician. NOTE: A cheap alternative is Compounded Testosterone Creams and Gels. Another emerging option is oral testosterone products.   Switch from intramuscular injections to lower-dose subcutaneous Subcutaneous Testosterone Injections. Two hundred thirty-two men took part in a University of California study. Baseline levels were recorded for all men in each of the four measurement areas and then again at 6–12 weeks post-treatment. The results showed that men who underwent subcutaneous testosterone (SubQ) injections had a 14% greater increase in total testosterone levels compared to the testosterone levels of intramuscular testosterone injection (IM) patients. SubQ patients also had a 41% lower hematocrit post-therapy than IM patients and 26.5% lower estradiol levels. For both groups of men, there were no elevated levels of PSA. [7]   Avoid or Reduce the Consumption of Red Meats. It is interesting because one of the criticisms that meat eaters level against vegetarians is that plant foods have many “anti-nutrients” that can slow down or bind with minerals such as iron. For example, organizations like Weston Price love to castigate vegetarians for their phytic acid consumption. Phytic acid is present in plant foods and binds to iron, magnesium, phosphorous, and calcium. It can, if overconsumed, lead to mineral deficiencies. However, Dr. Bernard points out that usually, it is likely very health-protective for most people because these minerals, as in the case of zinc and iron, are neurotoxic at even relatively low levels of tissue accumulation. Research has also shown that too much iron also contributes to heart disease, and there may be a link to colon cancer as well. [8]So, avoiding red meats, which are high in iron, stands a good chance of lowering your hemoglobin scores and protecting your long-term health unless some other preventative action is taken (such as giving blood). Actual dietary studies are required to support this statement. As a verification, one study of vegetarians and non-vegetarians found that females had significantly lower hemoglobin levels. Males had lower levels, but it may not have been statistically significant. [8] However, another study was more definitive and concluded: “It was found that hemoglobin, hematocrit, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, white blood cells, neutrophils, serum ferritin, and serum vitamin B12 in vegetarians were significantly lower than control subjects.” [11] Ferritin is a key measure, by the way, because it indicates that tissue levels of iron are lower and thus will likely cause less permanent damage. (This study did show that some vegetarians were iron deficient, as should be noted.)   Fix Sleep Apnea. Sleep apnea can cause depleted oxygen saturation values that can enhance the body's ability to produce more red blood cells and hemoglobin as a way to compensate for the low blood levels of oxygen during the sleep cycle. And, sure enough, there are studies that confirm this as well. [12] So, if your hematocrit, hemoglobin, or RBCs are running high, think about getting tested for sleep apnea. A recent study commented that “one possible explanation is that repeated episodes of nocturnal hypoxia (low oxygen condition) lead to a hypercoagulable state that predisposes patients to thrombotic (blood clotting) events. There is evidence supporting a wide array of hematological changes that affect hemostasis (e.g., increased hematocrit, blood viscosity, platelet activation, clotting factors, and decreased fibrinolytic activity).”   Reduce Inflammation. Hepcidin, the iron absorption-modulating hormone, can be decreased even further by inflammation. Checking for infections, CRP levels, etc., and then treating the underlying cause may help. [13]   Consider Curcumin (Turmeric). Turmeric or curcumin, is increasingly studied as an anti-inflammatory and anti-cancer agent. It binds to ferric iron in the gut and causes iron deficiency in mice. A case history reported a possible case of iron deficiency anemia in a human taking turmeric. [14]    Stop Smoking. Smoking reduces the amount of oxygen in the blood and makes the body produce more red blood cells and hemoglobin to compensate for that lower oxygen saturation.[14]    Treat High Blood Pressure with Losartan. If you have high blood pressure, consider taking Losartan.[15] Losartan can be safely and effectively used to normalize hematocrit in patients with COPD and erythrocytosis, an effect that could obviate the need for therapeutic phlebotomy.    Consider Grapefruit. Grapefruit extract (narigin) may decrease hematocrit [16]. There was no significant difference between ingesting 1/2 or 1 grapefruit per day, but a decrease in hematocrit due to ingestion of grapefruit was statistically significant at the p less than 0.01 level. However, discuss with your physician the fact that grapefruit can increase the blood levels of medications. The most important message of this article is that monitoring hematocrit every few months is a smart way to minimize cardiovascular risks associated with high hematocrit. You can buy your hematocrit and related tests on DiscountedLabs.com at affordable prices. Hematocrit is included in the CBC and other panels on Discounted Labs: Get Your Hematocrit Test Now Testosterone, Hematocrit, Ultrasensitive Estradiol and Prolactin Panel Hematocrit + Total and Free Testosterone References The Journal of Clinical Endocrinology & Metabolism, Volume 95, Issue 10, 1 October 2010, Pages 4743–4747 Eur Neurol, 1996, 36(2):85-8. Neuroepidemiology, 2008 December, 32(1): 40 46, “ Relation of Hemoglobin to Level of Cognitive Function in Older Persons” Neurology, 2011 Jul 19, 77(3):219-26, “Hemoglobin level in older persons and incident Alzheimer disease: prospective cohort analysis. Endocrinology. 2015 May; 156(5): 1623–1629. TRANSFUSION 2008; 48: 2197-2204. Comparison of Outcomes for Hypogonadal Men Treated with Intramuscular Testosterone Cypionate versus Subcutaneous Testosterone Enanthate SIU Academy. Choi E. 10/10/20; 309864; BSP-06.01  International Journal of Natural and Applied Sciences Vol. 2 (3) 2006: pp. 174–177, “Comparative study of the hemoglobin concentration of vegetarian and non-vegetarian subjects in Ogun state, Nigeria” World J Gastroenterol, 2006 September 21, 12(35): 5644-5650, “Hemoglobin induces colon cancer cell proliferation by release of reactive oxygen species” Iran J Ped Hematol Oncol, 2013; 3(2):73-77, “Effect of Thyroid Dysfunctions on Blood Cell Count and Red Blood Cell Indices” J Med Assoc Thai, 1999 Mar, 82(3):304-11, “Hematological parameters, ferritin and vitamin B12 in vegetarians” Can Respir J. 2011 Nov-Dec; 18(6): 338-348, “Coagulability in obstructive sleep apnea” Am J Kidney Dis. 2012;59(3):444-451

How to Safely Use PCT After TRT: Stopping Testosterone Replacement Therapy Table of Contents What is Post Cycle Therapy PCT? Why Do Men Stop TRT? Common reasons a man may need to discontinue TRT include: Normalizing Natural Testosterone After Stopping TRT PCT Treatments to Jump Start Natural Testosterone and Sperm Production How to Know if Your PCT Worked? Buy Discounted Lab's Post-PCT Panel  References: There is a common phrase most men will hear when they consider testosterone replacement therapy (TRT); it may be something they hear from friends or often what they read online: “TRT is for life.” There is an element of truth to this statement: when a man has low testosterone, in order to treat it and maintain healthy or optimal levels, he will always need TRT to achieve it. However, saying “it's for life” remains a somewhat inaccurate statement, and this is where we enter into the realm of what is commonly referred to as Post Cycle Therapy or PCT. TRT and anabolic androgenic steroids (AAS) can lead to dysfunction in HPTA (Hypothalamic-Pituitary-Testicular Axis). Supplemental testosterone can inhibit the release of the body's own testosterone production through negative feedback inhibition on LH levels. This feedback inhibition also results in the suppression of FSH levels, leading to the suppression of sperm production (spermatogenesis). During recent years a large surge in testosterone prescriptions and TRT clinics has unfortunately led to many men who have been misdiagnosed with low testosterone yet placed on TRT when it may not have been needed in the first place. If you are one of these men and you are considering discontinuing testosterone treatments, some protocols can help restore your hormone axis. You do not want to stop testosterone "cold turkey," which will lead to unnecessary symptoms that could last for many months. Understanding TRT and Its Impact on the Body Testosterone Replacement Therapy (TRT) can be a game-changer for men with low testosterone levels, but it’s crucial to understand how it impacts the body. TRT involves introducing exogenous testosterone into the body, which can disrupt the natural hormone production process. To grasp the full picture, we need to explore the Hypothalamic-Pituitary-Testicular Axis (HPTA) and how TRT affects it. The Hypothalamic-Pituitary-Testicular Axis and TRT The Hypothalamic-Pituitary-Testicular Axis (HPTA) is a sophisticated system that regulates testosterone production. It starts with the hypothalamus, which produces Gonadotropin-Releasing Hormone (GnRH). This hormone signals the pituitary gland to release Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). LH and FSH then stimulate the testes to produce testosterone. When you undergo Testosterone Replacement Therapy (TRT), this delicate balance can be disrupted. The introduction of exogenous testosterone can suppress the body’s natural production of LH and FSH, leading to a decrease in the body’s ability to produce testosterone on its own. Impact of TRT on Natural Testosterone Production The impact of TRT on natural testosterone production can be significant. When exogenous testosterone is introduced, it can lead to a suppression of LH and FSH, which are crucial for natural testosterone production. This suppression can result in various symptoms, such as low libido, fatigue, and decreased muscle mass. Over time, prolonged use of TRT can lead to hypogonadism, a condition where the testes are unable to produce sufficient testosterone. This is why understanding the effects of TRT on natural hormone production is essential for anyone considering or currently undergoing TRT. What is Post Cycle Therapy PCT? PCT is a treatment plan after discontinuing anabolic androgenic steroids (AAS). It is a phrase most commonly associated with what we might call “recreational steroid users” (RSU), such as bodybuilders: people who do not need steroid hormones like testosterone for medical reasons but use them for muscular competition advantage. In such cases, the individual will supplement with AAS for a set period of time, known as a steroid cycle, and then discontinue use. As his use of AAS shut down his natural testosterone production, just as it does with TRT, he will often implement a PCT plan for natural production to restart. Such plans will include Selective Estrogen Receptor Modulators (SERMs) or other items, such as the peptide HCG. The goal for the RSU, as eluded to prior, is to regain his natural production of testosterone as quickly and efficiently as possible. There is no guarantee this will work. There is no guarantee he will reach his previous levels before AAS use, although perhaps levels that accurate enough. Then we have the TRT patient; such an individual had low testosterone levels before he began administering exogenous testosterone. The use of testosterone, just as it did with the RSU, will stop his natural production. This is a factor that bothers many men, but let us keep in mind a very significant one: you already had low levels, your body was not able to produce enough, to begin with, and was not going to be able to, or you wouldn’t be on TRT. Nonetheless, there are reasons some men may find they need to discontinue use, and when that occurs, a PCT plan may be in order. Such a plan will not address his primary issue, low testosterone, but the goal here is to get at least some natural production back online. Why Do Men Stop Testosterone Replacement Therapy? Common reasons a man may need to discontinue TRT include: Need for Fertility TRT Cost TRT Side Effects or Health Issues Of the three potential reasons to stop TRT, fertility is the overwhelming reason for most men. Along with suppressing natural testosterone production, TRT can also have a negative impact on sperm production. There was a time in history not that long ago when it was thought exogenous testosterone would be touted as a male contraceptive. This idea died out when many men using testosterone found they were still able to impregnate a female. While many men on testosterone were found to be severely lacking in this department, it wasn’t enough or significant enough to market the hormone as an actual contraceptive. The other common reasons for discontinuing TRT are cost and side effects. These are the least common reasons in comparison to fertility needs or desires, but both are still possible. We all go through points in life where money can get a little tight; loss of a job, unexpected expenses – whatever the reason, if you find you need to stop, considering a PCT plan with your physician will make the transition easier. You’re still going to have low testosterone levels in the end – remember, you already had them, or you wouldn’t have started TRT in the first place – but you’ll hopefully be in a better position than you would be without, and in time, when your situation improves, you’ll be able to jump back on your TRT plan. The same may hold true for the individual who has side effect issues. This will be the least common reason for discontinuation of TRT but certainly within the realm of possibility. You could be one of the rare individuals who cannot control his hematocrit even with regular therapeutic phlebotomy. You could be someone that has other health concerns and, for whatever reason, need to discontinue use until you figure out what’s going on with your body. Hormonal imbalances, such as elevated estrogen levels, can also occur when stopping TRT, leading to conditions like gynecomastia. As was with the individual who was experiencing income issues, a PCT plan may be in order. Preparing for TRT Discontinuation Deciding to discontinue TRT is a significant step and should be approached with caution. One of the most critical aspects of stopping TRT safely is to do so under the guidance of a medical professional. Abruptly stopping TRT can lead to severe withdrawal symptoms and a dramatic drop in testosterone levels, which can be detrimental to your health. Gradual Tapering Under Medical Supervision When it comes to discontinuing TRT, gradual tapering is the safest approach. This process involves slowly reducing the dosage and frequency of testosterone administration to allow the body to adjust and begin producing testosterone naturally again. A healthcare provider can create a personalized tapering schedule based on factors such as the dosage and duration of your TRT use. This might involve reducing the amount of testosterone you inject or apply through gels over a set period. Regular check-ups with your healthcare provider are crucial during this time to monitor your progress and make any necessary adjustments to your tapering plan. This careful and monitored approach helps minimize withdrawal symptoms and supports the body’s natural transition back to producing testosterone on its own. By understanding the impact of TRT on your body and following a medically supervised tapering plan, you can safely discontinue TRT and support your body’s return to natural testosterone production. Normalizing Natural Testosterone After Stopping TRT For most men, studies have shown that for men who stop TRT, natural testosterone production can normalize within three months or longer, and spermiogenesis in well over a year. This is certainly not optimal when conception is the goal, which leads to the possible need for a PCT protocol. Post cycle therapy (PCT) is crucial in maintaining and recovering natural testosterone levels after using performance-enhancing drugs, as it helps enhance the body's own testosterone production. PCT Treatments to Restore Hormonal Balance and Jump Start Natural Testosterone and Sperm Production The use of the SERMs has been shown to increase testosterone levels to baseline in as little as 2-4 weeks. Studies have also shown spermiogenesis to improve significantly within 3-6 months. Clomid as we can easily see, greatly improves the time frames of recovery of these two important factors related to conceiving (testosterone and semen). PCT is crucial to restore hormonal balance, helping individuals recover from the use of anabolic steroids by promoting natural testosterone production and mitigating adverse effects caused by hormonal imbalances. HCG is another item commonly used in PCT for fertility purposes. HCG PCT has the ability to stimulate both testosterone production and spermiogenesis. It is not uncommon for fertility specialists to try both Clomid and HCG and, in some cases, in conjunction with one another. Unfortunately, there is much controversy among many fertility specialists regarding how much HCG should be administered for this purpose. While many physicians will prescribe SERMs in the range of 25-50mg per day to every other day, commonly prescribed HCG doses can run anywhere from 1000iu per day to 2500iu or even larger doses split into every other day schedules. Other common drugs used in this treatment, but to a lesser extent, include the SERM Tamoxifen Citrate, best known by its most notable trade name, Nolvadex. Treatments usually requires 4 weeks. Unfortunately, for some men, a PCT plan that includes some or all of these medications will not work. A HCG PCT plan is most likely to work in a TRT patient who is receiving treatment due to secondary hypogonadism. If a PCT plan has not worked – testosterone levels and sperm count have not increased – it is likely that the individual has primary hypogonadism, and as a result, will be best served (quality of life) by remaining on TRT. It’s imperative to note: this individual had primary hypogonadism prior to beginning TRT, he did not obtain it because of TRT. How to Know if Your PCT Worked? After going through PCT, physicians tend to check your testosterone blood levels and upstream hormones like LH and FSH to determine if your hormone axis has been restored. Discounted Labs has created a Post PCT Lab Test Panel that makes it easy for men to know if their PCT has successfully worked. This lab test panel is designed to measure the health and recovery of the Hypothalamic-Pituitary-Testicular Axis (HPTA) after attempting to normalize it spontaneously or with the use of Post Cycle Therapy (PCT) (with the use of clomiphene, hCG, and other treatments) It is suggested that this panel be done no sooner than 4 weeks after PCT cessation and in a fasting state (morning time). Lab tests included in the post-PCTest Panel: Ultra Sensitive Estradiol Test by Liquid Chromatography/Mass Spectrometry (LC/MS assay used to measure estradiol in men more accurately estradiol in men) Total and Free Testosterone LC/MS- No upper limit Luteinizing Hormone (LH) (responsible for activating Leydig testicular cells to produce your own testosterone). This hormone is shut down by testosterone replacement or AAS. Follicle Stimulating Hormone (FSH) (Responsible for activating Sertoli testicular cells to produce sperm). This hormone is shut down by testosterone replacement or AAS. CBC - Complete Blood Count (Includes hematocrit- red blood cell volume) CMP - Comprehensive Metabolic Panel (Includes liver and kidney function, glucose and electrolytes) For any man, simply discontinuing the use of testosterone can be difficult, to put it mildly. Your testosterone levels will completely bottom out when going the cold-turkey route, and this often. This severe sexual dysfunction, decreased energy, and even depression, to name a few of the consequences. Your levels may go up enough to at least function, to a degree, but it's going to take an enormous amount of time, as previously discussed. Cutting this time down significantly, and giving your body a boost in testosterone during the therapy process, is the only means of discontinuation that makes any sense, meaning some form of a PCT plan is a sensible approach. Buy Discounted Lab's Post-PCT Panel  References: Diagnosis and Management of Anabolic Androgenic Steroid Use Testosterone Use in the Male Infertility Population: Prescribing Patterns and Effects on Semen and Hormonal Parameters How to Stop TRT Safely