Page 3 - TRT Monitoring

Did you know that testosterone deficiency has a prevalence of up to 40% in adult males in the United States? A man is deficient in testosterone when his T levels fall below 300 ng/dL of blood. Although this is slightly worrisome news, there are multiple testosterone replacement options you can take advantage of these days. This article focuses on some of the most important testosterone products in 2023. Keep reading to learn key facts, statistics, price ranges, and optimal dosages related to your favorite testosterone products. Top Testosterone Replacement Therapy Options You Have in 2023 Fortunately, there are many ways you can get more testosterone into your system. There are patches, pellets, gels, injections, and even oral capsules that you can take once or twice a day. If you don't really fancy having to inject testosterone once a week, you can take capsules orally and reap all the benefits of testosterone replacement therapy. The following is a quick list of testosterone replacement products you can take advantage of to increase blood T levels. Administration of T products should only be done according to the strict guidance of your TRT doctor. FDA-Approved Testosterone Brands Androderm: Androderm is a transdermal testosterone patch that delivers testosterone through the skin. It is applied daily to maintain stable testosterone levels in men with low testosterone due to certain medical conditions[1]. This option is no longer used by most doctors since its efficacy was not good and it caused skin irritation. AndroGel: AndroGel is a topical testosterone gel that is applied directly to the skin, typically on the upper arms, shoulders, or abdomen. It is designed for daily use to help maintain consistent testosterone levels for men with low testosterone[1]. It comes in two concentrations. Fortesta: Fortesta is another topical testosterone gel applied to the skin, usually on the front and inner thighs. It is used for testosterone replacement therapy in males with low testosterone levels[2]. Testim: Testim is a testosterone gel applied daily to the skin, typically on the upper arms and shoulders, to help maintain consistent testosterone levels in men with low testosterone due to certain medical conditions[1]. Depo-Testosterone: Depo-Testosterone is an injectable form of testosterone prescribed for men with low testosterone levels. It is administered by a healthcare professional at regular intervals, typically every two to four weeks[2]. Testopel is a subcutaneous testosterone pellet that a medical professional implants under the skin. The pellets release testosterone over an extended period, typically three to six months[2]. Aveed: Aveed is an injectable testosterone undecanoate solution designed for long-acting testosterone replacement therapy. It is administered by a healthcare professional at regular intervals, typically every 10 weeks after an initial loading phase[2]. Natesto: Natesto is a testosterone nasal gel that is applied inside the nostrils for testosterone replacement therapy. It is used to treat men with low testosterone levels due to certain medical conditions[2]. Vogelxo: Vogelxo is a topical testosterone gel applied daily to the skin, usually on the upper arms, shoulders, or abdomen. It is used for testosterone replacement therapy in males with low testosterone levels[2]. Xyosted: Xyosted is a subcutaneous testosterone enanthate autoinjector for weekly self-administration. It is prescribed for men with low testosterone levels due to certain medical conditions[2]. Jatenzo: Jatenzo is an oral testosterone undecanoate capsule that the FDA has approved to treat certain types of hypogonadism in men. It is taken orally to help maintain stable testosterone levels in men with low testosterone [2] Testosterone Treatment Prices and Dosing Androgel 1% Price for a 30-day supply (in USD): 55-85 for the generic pump, 90-190 for 50 mg generic packets; also, around 650 USD for Brand 50 mg packets Delivery mode: pump and/or packet Dosage: 25 mg/2.5 g or 50mg/5g Where to apply shoulders, upper arms or on the abdomen Starting dosage: 50 mg daily dose early in the morning When to measure: in the morning before applying the gel Androgel 1.62% Price for a 30-day supply (in USD): 40-140 for the generic pump, 620-640 for Brand pump Delivery mode: pump and/or packet Dosage: 20.25 mg or 40.5 mg Where to apply shoulders or upper arms Starting dosage: 40.5 mg daily dose early in the morning When to measure in the morning before applying the gel Testim 1% Price for a 30-day supply (in USD): around 600-610 for packets Delivery mode: pump Dosage: 20.25 mg per actuation Where to apply shoulders or upper arms Starting dosage: one pump on each shoulder for a total of 40.5 mg early in the morning, it can also be applied on inner thighs When to measure: in the morning before applying the gel Fortesta 2% Delivery mode: pump Dosage: 50 mg or 100 mg Where to apply shoulders or upper arms Starting dosage: two pumps daily in the morning on each thigh When to measure: 2 hours after applying a dose Vogelxo Price for a 30-day supply (in USD): 100-350 for 1% pump, 120-350 for generic packets Delivery mode: shoulders or upper arms Dosage: 50 mg from 4 actuations of 12.5 mg testosterone Where to apply shoulders or upper arms Starting dosage: 50 mg daily in the morning When to measure before applying a dose Androderm Delivery mode: patch applied at night after 10 PM Dosage: 2 mg per day, 2.5 mg per day, 4 mg per day or 5 mg per day Where to apply: abdomen, upper arms, thighs, back Starting dosage: 4 mg per day When to measure: 12 hours after skin application Natesto Price for a 30-day supply (in USD): 195-300 for 5.5 mg/actuation Delivery mode: intranasal pump Dosage: 5.5 mg per pump actuation Where to apply intranasal Starting dosage: 11 mg (2 actuations) 3 times per day at an interval of 6-8 hours When to measure: 2 hours after nasal application Jatenzo Price for a 30-day supply (in USD): around 950 for 237 mg BID pill Delivery mode: oral capsule Dosage: 158 mg, 198 mg, or 237 mg Where to apply oral Starting dosage: 237 mg capsule twice a day (one in the morning, one in the evening) When to measure: 6 hours after the morning dose Testopel Delivery mode: pellet Dosage: 75 mg per pellet Where to apply can be inserted under the skin, in the fat of the buttocks, thigh or lower abdominal wall Starting dosage: 150-450 mg every 3 to 6 months When to measure: at the end of the dosing interval Aveed Delivery mode: injectable solution Dosage: 100 mg/10 ml vial, 200 mg/1-10 ml vial or 750 mg/3 ml vial Where to apply: intramuscular in the glute or thigh muscles Starting dosage: 750 mg (3 ml) in the beginning, then after 4 weeks then after every 10 weeks; 75-100 mg/week also or 150-200 mg every 2 weeks When to measure: injections are administered every 10 weeks and T measurement should be done somewhere in between injections (after 5 weeks or so since the last one) Xyosted Price for a 30-day supply (in USD): 455-575 for 50 mg, 75 mg and 100 mg injections Delivery mode: the solution is placed in the autoinjector Dosage: 50 mg, 75 mg or 100 mg respectively Where to apply: in the abdominal region under the skin Starting dosage: 75 mg applied under the skin once a week When to measure T levels: trough concentrations are measured 7 days after the most recent dose and only after 6 weeks since the beginning of treatment. These are just a few popular testosterone replacement products available in the US. Keep in mind that you can also procure testosterone enanthate in 5 ml (1000mgs) vials from certain pharmacies. This option usually costs less than $30 for a 30-day supply and the testosterone can be injected by each patient without requiring a doctor's visit. Similarly, TRT patients can also choose to use generic testosterone cypionate or enanthate as 400 mg to 800 mg per month that can be injected into muscle (deep IM or shallow IM) or under belly fat (subcutaneous) . The price for a 30-day supply starts at around $30 and it can go up to $85 . (Source: GoodRx). Other affordable sources of testosterone treatments can be purchased from compounding pharmacies like Empower in Houston. Check Out How AUA and ES Guidelines Differ on Testosterone Ranges AUA stands for American Urology Association and ES stands for Endocrine Society. They provide detailed insights and standards on how to interpret hormone levels and blood test results. In some cases, these committees can give different interpretations when it comes to testosterone levels. AUA Guidelines: What is a Normal Testosterone Range and Follow Up? According to the American Urology Association (AUA), you should measure your testosterone levels in the morning in a fasted state to get accurate results. The normal range is between 450 ng/dL and 600 ng/dL of blood. If your levels fall below 300 ng/dL of blood, you are considered to be deficient in testosterone. If you start testosterone replacement therapy, your first evaluation should be between 2 and 4 weeks after beginning treatment. You will also have to attend follow-up visits 6 to 12 months after starting TRT. ES Guidelines: What is a Normal Testosterone Range and Follow Up? On the other hand, the Endocrine Society (ES) gives slightly different reference ranges. For example, the normal testosterone range is between 264 ng/dL and 916 ng/dL of blood. The best moment to test your T levels is early in the morning in a fasted state. Testosterone deficiency is confirmed if your T levels fall below 264 ng/dL of blood.  TRT follow up visits should be done after 2-3 months and after 6 to 12 months from the start of your testosterone replacement protocol. How to Get Your Own Affordable Testosterone Test Remember that now it's easier than ever to check your testosterone levels and see if you are a suitable candidate for testosterone replacement therapy. If your T levels fall below 350 ng/dL and have low testosterone symptoms then you should talk with a TRT doctor and see what testosterone replacement options you have. Check your testosterone levels quickly and confidentially by ordering a total and free testosterone test from DiscountedLabs today. Key Terminology and Facts About Testosterone It's important to also have some basic understanding of how testosterone works in the body, so you can make better decisions when talking with your TRT doctor. For instance, the Leydig cells in your testicles produce more than 95% of your testosterone. Testosterone daily production ranges from 3 mg to 11 mg and it peaks early in the morning. Healthy adult males have the highest concentration of testosterone early in the morning and it gradually drops throughout the day. That's why the best time to measure your T levels is early in the morning to get accurate results. Natural Testosterone Short half-life - your testosterone has a half-life between 10 and 100 minutes. It peaks once every 3 hours as the luteinizing hormone stimulates the Leydig cells to produce more testosterone. With the passing of time, these cells become less sensitive to LH and they produce increasingly low T levels. It's estimated that males lose about 1% of their testosterone production every year after the age of 30. 2 percent is free; about 2% of your total testosterone level is free. This means that it circulates freely through the bloodstream and it can bind to other organs or tissues. 70% of your testosterone is bound to sex hormone-binding globulin and nearly 30% is bound to albumin. Testosterone metabolism - fractions of your testosterone are converted into other hormones and substances. For example, from 5% to 8% of your testosterone is converted into dihydrotestosterone (DHT). This hormone is responsible for prostate maturation and the growth of the body, as well as facial and pubic hair. About 0.3%–0.5% of your testosterone is also converted into estradiol by the aromatase enzyme. Some of the main roles of estradiol in men are involved with libido and bone health. Trough concentration - this refers to the lowest  concentration of a drug in the bloodstream immediately before injecting or administering another dose. It's highly recommended to measure your testosterone levels at trough concentration because this will produce the most accurate results. Based on these results, TRT doctors can make more accurate adjustments to your protocol. Find Out More About Testosterone Products! This is just a brief overview of some of the most popular testosterone products in the US, but there's plenty more high-quality information out there. Visit Excelmale.com and learn everything you need to know about testosterone, TRT, how to interpret your blood test data, and how to tweak your protocol for optimal results. Also, you can download the Testosterone Replacement Options paper from this link.   References: [1] "FDA-approved testosterone formulations include the topical gel, transdermal patch, buccal system (applied to upper gum or inner cheek), and injection. The manufacturers of two prescription..." URL: https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/testosterone-information [2] "by Drugs.com Brand names of testosterone include Androderm, AndroGel, Fortesta, Testim, Depo-Testosterone, Testopel, Aveed, Natesto, Vogelxo, Xyosted, Jatenzo, Tlando, and Kyzatrex. Testosterone is an androgen indicated for testosterone replacement therapy in males." URL: https://www.drugs.com/medical-answers/brands-testosterone-3510863/   Recommended Sources: Testosterone Replacement Therapy Options | Excel Male TRT Forum Testosterone Replacement Products in the U.S.: Video Review by Nelson Vergel - ExcelMale Testosterone Test Near Me: Your Complete Guide Testosterone levels show steady decrease among young US men        

Embarking on the path of Testosterone Replacement Therapy (TRT) often evokes a blend of enthusiasm and concern among men. The allure of renewed vigor, heightened sexual desire, and robust muscle growth is enticing. However, there are a lot of less well-known aspects that your healthcare provider might not immediately disclose. For instance, were you aware that TRT could affect your fertility or exacerbate your sleep apnea? While TRT heralds a new dawn for many, it doesn’t offer a universal remedy. In light of this, we have meticulously curated a comprehensive list of 18 pivotal aspects that might elude your doctor's attention but are indispensable for you to grasp. Venture further to unearth the profundities of TRT. Low Blood Levels of Testosterone and Associated Risks: < 450 ng/dl (15.3 nmol/l) - Risk of metabolic syndrome Reference: Dhindsa, S., Miller, M. G., McWhirter, C. L., Mager, D. E., Ghanim, H., Chaudhuri, A., & Dandona, P. (2010). Testosterone concentrations in diabetic and nondiabetic obese men. Diabetes Care, 33(6), 1186-1192. PubMed < 400 ng/dl (15.3 nmol/l) - Venous leakage (internal penile damage) risk Reference: Yassin, A. A., & Saad, F. (2017). Testosterone Deficiency and Testosterone Treatment in Older Men. Gerontology, 63(2), 144–156. PubMed < 350 ng/dl (11.9 nmol/l) – All-cause death risk and anemia risk Reference: Khaw, K. T., Dowsett, M., Folkerd, E., Bingham, S., Wareham, N., Luben, R., ... & Day, N. (2007). Endogenous testosterone and mortality due to all causes, cardiovascular disease, and cancer in men. Circulation, 116(23), 2694-2701. PubMed < 300 ng/dL (10.2 nmol/L) - Lowered libido, weight gain & Diabetes risk increased Reference: Traish, A. M., Saad, F., & Guay, A. (2009). The dark side of testosterone deficiency: I. Metabolic syndrome and erectile dysfunction Journal of Andrology, 30(1), 10-22. PubMed < 300 ng/dL (10.2 nmol/L): Quartile risk of fractures (osteoporosis), memory-related issues and depression risk increases Reference: Orwoll, E., Lambert, L. C., Marshall, L. M., Phipps, K., Blank, J., Barrett-Connor, E.,... & Cummings, S. (2006). Testosterone and estradiol are common among older men. The Journal of Clinical Endocrinology & Metabolism, 91(4), 1336-1344. PubMed < 250 ng/dl (8.5 nmol/l): Arterial plaque (arteriosclerosis) & sleep quality affected Reference: Vlachopoulos, C., Ioakeimidis, N., Miner, M., & Aggelis, A. (2014). Testosterone deficiency: a determinant of aortic stiffness in men Atherosclerosis, 233(1), 278-283. PubMed < 235 ng/dl (8.0 nmol/l) hardening of arteries (dialysis patients) Reference: Carrero, J. J., Qureshi, A. R., Parini, P., Arver, S., Lindholm, B., Bárány, P., ... & Stenvinkel, P. (2009). Low serum testosterone increases mortality risk among male dialysis patients. Journal of the American Society of Nephrology, 20(3), 613-620. PubMed < 200 ng/dl (6.8 nmol/l) morning erections decrease Reference: O'Connor, D. B., Lee, D. M., Corona, G., Forti, G., Tajar, A., O'Neill, T. W., ... & EMAS Study Group. (2011). The relationships between sex hormones and sexual function in middle-aged and older European men. The Journal of Clinical Endocrinology & Metabolism, 96(10), E1577-E1587. PubMed < 150 ng/dl (5.1 nmol/l) - Increased inflammation (TNF-alpha) Reference: Malkin, C. J., Pugh, P. J., Jones, R. D., Kapoor, D., Channer, K. S., & Jones, T. H. (2004). The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. The Journal of Clinical Endocrinology & Metabolism, 89(7), 3313-3318. PubMed The Unspoken Implications of TRT Your doctor might overlook mentioning certain ramifications when you commence Testosterone Replacement Therapy (TRT): Fertility and TRT Sperm Count Drop: TRT lowers the levels of Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), two hormones that help make sperm. If preserving fertility is a priority, discuss with your healthcare provider incorporating Clomiphene or hCG into your TRT regimen. Hematological Effects Blood Viscosity Increase: TRT can escalate your blood's hematocrit level, thereby increasing its viscosity. Although some practitioners may advise halting TRT, this side effect can be managed adeptly through blood donations or therapeutic phlebotomy. Beware; frequent blood donations might deplete iron levels and induce fatigue. Impact on Natural Testosterone Production Suppression of Endogenous Testosterone: TRT suppresses your body’s natural testosterone synthesis, which may rebound anywhere between a few weeks and six months post-cessation. The Multifaceted Benefits and Varied Efficacy of TRT Muscle Mass, Fat Reduction, and Sexual Health Sex Drive and Physique Enhancement: TRT predominantly augments libido, muscle mass, and fat metabolism in men. However, its effectiveness varies, and meticulous dosage and frequency adjustments along with side effect management are imperative. It’s not a panacea. Administration Techniques Methods of Injection: Contrary to what most people think, testosterone can be injected superficially (IM) or deeply (subcutaneously) into the muscle using a 1/2-inch, 27-29-gauge insulin syringe. Topical Testosterone Efficacy of Gels and Creams: Testosterone gels and creams are efficacious but often under-dosed by physicians. More concentrated compounded products or dosage adjustments based on blood levels can rectify this. Dosage Frequency Optimized Injection Schedules: Shifting from biweekly 200mg injections to weekly 100mg or twice-weekly 50mg dosages can often yield better results. Addressing Concerns and Optimizing TRT Outcomes Sleep Apnea and TRT Sleep Apnea Dynamics: TRT could exacerbate central sleep apnea but might alleviate obstructive sleep apnea over time as weight loss occurs. Erectile Function Erectile Function and Libido: TRT enhances erectile function and libido in a majority of men. Some may benefit from adjunctive low-dose daily Cialis, which also harbors cardiovascular advantages. Self-Monitoring and Telemedicine Monitoring Blood Tests: Companies like DiscountedLabs.com enable self-monitoring of blood tests without a doctor visit. Moreover, telemedicine facilitates access to testosterone doctors nationwide, albeit mostly without insurance coverage. Debunking Misconceptions and Enhancing TRT Knowledge Prostate Health and Cardiovascular Effects Prostate Cancer and Heart Attacks: Contemporary evidence refutes the notion that TRT triggers prostate cancer or heart attacks, though vigilant monitoring is crucial for optimal cardiovascular outcomes. Community Support and Knowledge Sharing Leveraging Online Communities: Engage with seasoned TRT users on platforms like the ExcelMale forum or Testosterone Replacement Discussion Facebook group to broaden your understanding. Comprehensive Testing Holistic Blood Analysis: Ensure your doctor conducts a thorough blood analysis encompassing total and free testosterone, DHT, thyroid function, and prolactin (especially for those with extremely low T levels) to rule out pituitary adenomas. Insurance, Professional Expertise, and Addressing Common Hurdles Insurance and TRT Insurance Coverage: Insurance coverage for TRT products is often restrictive, but utilizing a compounding pharmacy can be a viable alternative. Expertise in TRT Management Urologists Leading the Charge: The burgeoning expertise of urologists in TRT management is notable, with extensive TRT-centric discussions now a staple at urology conferences. Identifying and Addressing Co-morbidities Co-morbid Conditions: Men with co-existing health issues may encounter challenges in reaping TRT benefits, warranting a thorough cardiovascular assessment for those experiencing water retention and hypertension. Estradiol Management Misconceptions About Estradiol: People often get the wrong idea about this hormone, which plays a big part in libido, bone health, and brain function, because it is not given enough attention when it comes to management. Emerging evidence suggests aromatase inhibition might be unnecessary in TRT management. Armed with this extensive knowledge, you’re now better positioned to make informed decisions on your TRT journey. Remember, individualized consultation with healthcare professionals is indispensable for optimizing your TRT experience.    

The prostate gland plays a pivotal role in men’s health, and its well-being is often a topic of great concern, especially when it comes to prostate cancer, a leading cause of death among men in the United States. This article delves into the intricacies of prostate health, detection methods for prostate cancer, and the debated connection between testosterone replacement therapy (TRT) and prostate cancer. Prostate Cancer Prevalence and Detection As men age, the occurrence of small, hidden prostatic lesions increases, which could potentially turn cancerous over time. The prevalence of these lesions is around 30% in American men aged over 45, and this figure soars to over 80% for those above 80 years of age. The transformation of these lesions into cancerous cells is often linked to genetic factors and lifestyle conditions, including diet. To detect prostate cancer, healthcare providers employ a variety of methods: Prostate-Specific Antigen (PSA) assays Digital Rectal Examination (DRE) Transrectal Ultrasound It's advisable for men, especially those above 40 or with a family history of prostate cancer, to undergo a DRE before commencing testosterone replacement therapy and every six months thereafter. While DRE may be uncomfortable, it's a small price to pay for ensuring good health. Any abnormal rectal exam findings, a PSA increase of more than 2 ng/mL, or a PSA level over 4 ng/mL usually necessitate further evaluation by a urologist, often involving an ultrasound and prostate biopsies. However, the PSA and DRE methods lack sensitivity and specificity. In some instances, benign prostatic hyperplasia (BPH), a non-cancerous inflammation, may falsely elevate PSA levels, while 25% of prostate cancer patients show normal PSA levels. As it turns out, needle biopsies can find hidden prostatic lesions in men whose PSA levels and ultrasound results are normal. Testosterone Replacement Therapy and Prostate Cancer: Unveiling the Connection The role of Testosterone Replacement Therapy (TRT) in PSA elevation or prostate cancer development has been a topic of considerable debate. Prostate cancer is initially androgen-dependent; thus, TRT is discouraged for men diagnosed with prostate cancer. However, a comprehensive analysis encompassing data from 18 studies revealed no significant link between blood levels of androgens and an increased risk for prostate cancer (Journal of the National Cancer Institute, 2008). Intriguingly, some emerging data suggest that high doses of testosterone may be beneficial in treating certain types of prostate cancer. A different study that looked at 149,354 men who were diagnosed with prostate cancer between 1991 and 2007 found that those who were treated with TRT did not have higher rates of death or use of Androgen Deprivation Therapy (ADT). The study, published in the Journal of Sexual Medicine (2014), concluded that TRT, post-prostate cancer diagnosis and treatment, doesn't exacerbate mortality rates or the necessity for ADT, even with prolonged TRT duration. Conclusion The dialogue surrounding prostate cancer, its detection, and the implicated role of TRT is complex. While the journey towards unambiguous understanding continues, regular screenings and open discussions with healthcare providers remain crucial for maintaining prostate health and making informed treatment decisions.   Reference: Kaplan, A. L., Lenis, A. T., Shah, A., Rajfer, J., & Hu, J. C. (2014). Testosterone Replacement Therapy in Men with Prostate Cancer: A Time-Varying Analysis. Journal of Sexual Medicine. For more insights on this topic, refer to: Does Testosterone Cause Prostate Cancer? Can Men Treated for Prostate Cancer Use TRT?

Starting Testosterone Replacement Therapy (TRT) is a significant decision that can have a profound impact on your health and well-being. While it offers numerous benefits, like enhanced mood, improved sexual performance, and increased muscle mass, there are also potential side effects and nuances that your healthcare provider might not fully explain. Below, we delve into critical aspects of TRT that every man should be aware of. But first, did you know that you can easily and affordably monitor your testosterone levels through DiscountedLabs.com? It's an excellent way to keep track of your health without the hassle of a doctor's visit. Table of Contents Impact on Sperm Count How TRT Affects Your Fertility Blood Viscosity and Hematocrit Managing Increased Red Blood Cells Shutdown of Natural Testosterone Production Recovery Post TRT Dose and Effectiveness TRT is Not a Magic Bullet Different Injection Methods Subcutaneous vs. Intramuscular Testosterone Gels and Creams Topical TRT: Right Dose, Right Results Optimal Injection Frequency The Shift Towards Frequent Dosing Sleep Apnea TRT and Sleep Quality Erectile Function and Libido The Added Benefits and Limitations Monitoring Your Blood Tests Taking Charge of Your Health Telemedicine for TRT Access to Expertise Prostate Cancer and Heart Attacks Debunking the Myths Community Support You're Not Alone Important Blood Tests Beyond Total Testosterone Insurance Limitations Navigating the System Consult a Urologist The Go-To Experts on TRT Comorbidities Risks and Workarounds The Estradiol Obsession Re-Thinking Estradiol Management Impact on Sperm Count How TRT Affects Your Fertility One aspect of TRT that is often overlooked is its effect on fertility. TRT reduces levels of LH (Luteinizing Hormone) and FSH (Follicle Stimulating Hormone), which are crucial for sperm production. If you plan on having children, it's essential to discuss fertility preservation options with your healthcare provider. Treatments like clomiphene or the addition of hCG can be useful. Blood Viscosity and Hematocrit Managing Increased Red Blood Cells TRT may lead to an increase in hematocrit, or the amount of red blood cells in your blood, thereby making it thicker. While some doctors may suggest pausing TRT, this condition can be managed through blood donations or therapeutic phlebotomy. However, frequent blood donations can lead to iron depletion and fatigue. Learn more about managing high hematocrit here. Shutdown of Natural Testosterone Production Recovery Post TRT Once you're on TRT, your natural testosterone production will decline. Usually, your body can recover its testosterone levels within a few weeks to six months after stopping TRT, but it's essential to know that this therapy isn't a temporary commitment. Dose and Effectiveness TRT is Not a Magic Bullet Though TRT can dramatically improve quality of life by enhancing sex drive, muscle mass, and fat loss, the effectiveness varies from person to person. Factors like dose, frequency, and side effect management play a crucial role. Learn about the average time to see benefits. Different Injection Methods Subcutaneous vs. Intramuscular There's a common misconception that testosterone must be injected deep into the muscle. However, you can also use a 1/2 inch 27-29 gauge insulin syringe for subcutaneous injections. Read more about injection methods here. Testosterone Gels and Creams Topical TRT: Right Dose, Right Results Gels and creams offer a less invasive way to administer testosterone, but the effectiveness depends on the right dose and concentration. Doctors often miss this, so make sure you monitor your levels closely. Optimal Injection Frequency The Shift Towards Frequent Dosing Traditionally, doctors prescribed testosterone injections at 200 mg every two weeks. However, many are moving towards more frequent dosing schedules, like 100 mg per week or even 50 mg twice per week, using insulin syringes. Sleep Apnea TRT and Sleep Quality Be cautious if you have central sleep apnea, as TRT can worsen this condition. However, weight loss achieved through TRT may improve obstructive sleep apnea over time. Erectile Function and Libido The Added Benefits and Limitations While TRT generally improves libido, the results regarding erectile function are mixed. Some men also use low-dose Cialis for additional cardiovascular benefits. Read more about the benefits of Cialis. Monitoring Your Blood Tests Taking Charge of Your Health One of the great advantages of modern technology is that you can monitor your own blood tests via DiscountedLabs.com, without needing a doctor's appointment. Telemedicine for TRT Access to Expertise For those living in areas without easy access to a TRT specialist, telemedicine is a viable option. Just note that most telemedicine doctors don't accept insurance. Prostate Cancer and Heart Attacks Debunking the Myths Contrary to common belief, TRT has not been proven to cause prostate cancer or heart attacks. Proper monitoring of hematocrit, HDL, and blood pressure is crucial, however. Community Support You're Not Alone Don't underestimate the value of community support. Platforms like Excel Male Forum offer a wealth of shared experiences and advice from men who have been on TRT for years. Important Blood Tests Beyond Total Testosterone Many doctors only measure total testosterone and often neglect other important markers like free testosterone, DHT, and thyroid function. Ensure these are part of your monitoring plan. Insurance Limitations Navigating the System Most insurance companies have limitations on which TRT products they cover. You can bypass insurance restrictions by going through a compounding pharmacy. Consult a Urologist The Go-To Experts on TRT Urologists are becoming increasingly knowledgeable about TRT, making them an excellent resource for anyone considering this treatment. Comorbidities Risks and Workarounds Some men might not see the benefits of TRT due to other health issues, such as metabolic disorders that can lead to water retention and high blood pressure. A full work-up with a cardiologist is advisable for these men. The Estradiol Obsession Re-Thinking Estradiol Management Many men obsess about their estradiol levels and are often prescribed high doses of aromatase inhibitors, which may not be necessary. Learn more about the role of estradiol in men here. In conclusion, TRT is a multifaceted treatment that requires proper understanding and management. Keep yourself informed and consider using DiscountedLabs.com for your testosterone level monitoring. Take control of your health today!

Table of Contents SHBG and the Free Testosterone Relationship What Causes High SHBG? Other factors that can contribute to high SHBG include:   Get Your Levels Checked: SHBG Test, Free & Total Testosterone Test How to Lower SHBG Levels: Very Low SHBG : Low SHBG has also been associated with: Is SHBG an Enemy of Hormone? - Emerging Studies References: Testosterone is the primary and dominant male hormone. It is responsible for numerous functions within the human body in men and women, and when levels are too low, it can lead to multiple health issues. Unfortunately, as many know, testosterone levels naturally decline as we age. Numerous external factors can contribute to lower levels of testosterone. In either case, age or external, symptoms occur, problems arise, and solutions are needed to stop the decline. For many men, testosterone replacement therapy (TRT) is the answer to this problem.  Men should ensure that their testosterone free and total, estradiol and other hormone factors are within normal levels. One of those hormone tests to monitor is the Sex Hormone Binding Globulin (SHBG) test.   SHBG and the Free Testosterone Relationship   When our body produces testosterone or provides it exogenously, a set level of testosterone flows through the body. This testosterone blood level can be measured precisely through a simple blood test aptly referred to as the Total Testosterone blood test. For most adult men, when testing their total testosterone, if it falls in the 350 ng/dl to 1100 ng/dl range, this will be considered medically optimal. Such individuals, even exhibiting low testosterone symptoms, will often not be prescribed TRT. In some cases, this may be a correct diagnosis; in other cases, symptoms exist for different reasons, but in most cases, something else is at play, which makes SHBG important.   While useful, measuring total testosterone is only useful with also measuring Free Testosterone. Free testosterone is a small fraction of your total testosterone. It is often referred to as "unbound," meaning the testosterone your body will use for its intended androgenic function. Free testosterone is so important that if your total testosterone levels are within range, if free testosterone levels are low, in most cases, the man will be symptomatic of low testosterone. This issue is often due to high levels of SHBG in the body.   For this reason, many men will attempt to lower their SHBG or even fret over it. However, SHBG serves an essential purpose. As is with estrogen, too much can be problematic, but so can too little. SHBG is no different.   Of all the testosterone flowing through your body, only 2% is what we can refer to as unbound or free testosterone. From a layman's perspective, to increase free and unbound testosterone, they'd need to increase their total testosterone. Unfortunately, it doesn't always work that way – it often helps and often fixes the issue, but not always – and here's why: our testosterone is bound to albumin and sex hormone-binding globulin (SHBG). Approximately one-third of total testosterone binds to albumin, and the rest to SHBG.   Albumin is a protein that binds testosterone, and we can say it does so loosely. This protein carries testosterone through the bloodstream and releases it as needed. The testosterone detaches and becomes what's often referred to as bioavailable or free testosterone. The testosterone that separates from albumin becomes the testosterone that influences your body's functions from sex organs, muscle tissue, brain function, and a host of other areas of bodily function. Testosterone attached to SHBG cannot do this; it is attached and does not detach.   What Causes High SHBG?   As testosterone attached to SHBG is relatively useless, if SHBG levels increase within the body, there will be more attaches and less free testosterone to circulate. Conversely, lower levels of SHBG are associated with higher levels of free testosterone, which is often associated with positive influences on bodily functions, such as libido, mood, muscle mass, etc.   Numerous factors influence how much sex hormone-binding globulin we have in our bodies. Age is one of the primary factors that affect SHBG. Often as we age, SHBG levels increase, and as a result, free testosterone levels go down. Even if our total testosterone levels remain high or optimal, our bioavailable testosterone decreases if SHBG levels increase.   Other factors that can contribute to high SHBG include: Fatty Liver Excessive or what we might call chronic alcohol consumption can lead to a fatty liver and impending higher levels of SHBG and corresponding lower levels of free testosterone. The disease can also be a factor, such as cirrhosis or cancer. Thyroid issues An underactive and overactive thyroid can lead to elevated SHBG, not to mention issues associated with the thyroid. Overactive thyroid or hyperthyroidism is often associated with graves' disease, thyroid nodules, or thyroiditis. It can also exist due to abuse of thyroid medications, such as Cytomel (T3). Underactive thyroid or hypothyroidism may be caused by inflammation of the thyroid gland, pituitary damage, too little iodine in the diet, or genetic factors, along with other possible reasons. Elevated estradiol High levels of estradiol can occur for numerous reasons, which are not limited to using certain antibiotics, some mental health medications, obesity, and abuse of exogenous testosterone. Obesity & High triglycerides While not as expected of a factor for increasing SHBG, being overweight with a low lipid profile can negatively impact. Inflammation While some level of inflammation is necessary for general health in the fight against disease or injury, what we might call chronic inflammation can lead to increases in SHBG and corresponding lower levels of free testosterone   Get Your Levels Checked: SHBG Test, Free & Total Testosterone Test   Testing your SHBG levels along with both total and free testosterone is particularly important if one wants to get to the bottom of hypogonadism (low testosterone) symptoms they may be experiencing. Remember, a total testosterone test alone, which some physicians will run, is not enough. For most adult men, SHBG levels will run between 10 nmol/L and 60 nmol/L if in the optimal range. If SHBG levels are greater than 60 nmol/L and your free testosterone is less than 2% of your total testosterone, there is a good chance your SHBG levels are too high.   Discounted Labs sells several lab test panels that measure SHBG levels that you can buy without a doctor's visit:   Testosterone (Total and Free), SHBG, CBC - Hematocrit, Ultrasensitive Estradiol and PSA   Testosterone, Free, Bioavailable and Total (Upper Limit T 1,500 ng/dL) plus SHBG   CBC, CMP, TT, FT, Lipids, Prolactin, Ultra-Sensitive Estradiol, and SHBG   Testosterone, Free, Bioavailable, and Total, LC/MS (No Upper Limit) plus SHBG   As we now understand SHBG, our next question is what can be done to lower it, increasing free testosterone in the body? There is nothing we can do about aging. As each day passes, we grow older, but there are still things we can do that will improve this factor.   How to Lower SHBG Levels:   The most obvious answer to the problem of low free testosterone and high levels of SHBG is to increase testosterone. Exercise more, consume a cleaner diet, and lose weight; all of these things will increase your testosterone levels. Your levels may not increase massively, but some increase means a higher total to pull from and a greater amount of free testosterone based on the 2% fraction. If this isn't enough - perhaps you're not reaching a 2% fraction due to elevated SHBG – one may need to consider talking to their doctor about testosterone supplementation. However, even if supplementing with exogenous testosterone, the habits mentioned are good for overall health and can only have a positive impact.   Another possible solution, and one of the more commonly needed, is lowering estradiol levels in the body. We tend to think estrogen hormones are needed for females only, but they are also crucial for men, granted in smaller amounts. As it pertains to estrogen, too much estradiol can lead to elevated levels of SHBG. If testosterone levels are also low, this can lead to even more negative factors. But it's important not to get carried away as estradiol that's too low will bring with it numerous symptoms; in fact, your life could be miserable in that regard.   Many men who are at least somewhat familiar with testosterone have been wrongly been told that too much testosterone can lead to gynecomastia due to elevated levels of estrogen in the body due to the aromatization of testosterone to estrogen. But low levels of testosterone in the body with present high levels of SHBG and estradiol can have the effect of causing gynecomastia. In order to combat high levels of estradiol, avoiding certain foods, especially those that are soy-based, will be important. Equally important is living a healthy lifestyle and incorporating what was mentioned above: adequate exercise, a healthy diet, and getting enough sleep. These things will help lower estradiol. Some men will also need medical help through medications known as aromatase inhibitors if they have gynecomastia, although most men on TRT do not need an AI. Too many men have relied on aromatase inhibitors out of fear for too many years. In reality, most men who supplement with exogenous testosterone can, in fact, control estrogen via non-medicated factors.   Some studies have shown that supplementation with DHEA (Dehydroepiandrosterone) may also lower SHBG. However, more study is needed to understand this properly, as too much DHEA can prove problematic. High doses of DHEA supplements have been associated with increased estradiol, so you must speak to your doctor first before beginning such a supplementation regimen.   Very Low SHBG :   We are then left with one factor we've yet to discuss much because it isn't all that common: low SHBG, or rather, levels of SHBG that are too low. Levels of SHBG that are too low may be an indicator of other underlying health issues. This may be an indicator of a metabolic problem. Low levels of SHBG are a standard indicator of those with diabetes. It doesn't appear, as data suggests, that insulin resistance is caused by low SHBG, but it may be a useful marker. More data is currently needed on this topic.   An A1c test will be needed to know with certainty in terms of your diabetic health.   While low SHBG is not a common concern for most men, new data has produced interesting results and information. A recent study published in the Journal of Clinical Endocrinology and Metabolism provides such information.   The process showed a man with undetectable levels of SHBG and low levels of testosterone accompanied by nearly a decade of hypogonadism symptoms. They discovered a family with a missense mutation in the SHBG gene from studying this individual. Interestingly enough, they found this issue did not interfere with the individual's spermatogenesis or general gonadal development. This leads the study to conclude SHBG may not play a significant role in the maturation of the male species physiologically or sexually.   More interesting than the JCEM study is things that new data suggest may negatively impact all men. Low levels of SHBG have recently been associated with three medical conditions that are known to be the silent killers of many men: heart disease, metabolic syndrome, and diabetes. Again, currently, it is being viewed as a marker and not as direct causation, but this new information is important as it acknowledges that more studies must be done.   Low SHBG has also been associated with:   Obesity Obesity is a factor we all well understand and is an issue that leads to problems in many health areas, and often in numerous possible directions. Cushing Disease It is associated with extended exposure to high levels of cortisol. Hypothyroidism It is associated with an under-active thyroid. Excessive levels of growth hormone Exceedingly rare for most, although possible via genetic factors or abuse of exogenous forms. Abuse through anabolic steroids     Is SHBG an Enemy of Hormone? - Emerging Studies   As we mentioned, androgens like testosterone and DHEA and estrogens are transported to the sex hormone binding globulin (SHBG). SHBG is believed to keep sex hormones inactive and to control the amount of free hormones that enter cells by passive diffusion. Contrary to the free hormone hypothesis, some researchers have demonstrated that megalin, a receptor in ovaries and testicles, acts as a pathway for cellular uptake of biologically active androgens and estrogens bound to SHBG. We will see more data on this newly found receptor that actually enables the body to use hormones bound to SHBG in the near future.   In endocrinology, the body has no “harmful” or “good” hormone. Their balance and harmony with each other matters for the best health.     References:   Ding et al. Sex hormone-binding globulin and risk of type 2 diabetes in women and men. The New England Journal of Medicine. Aug 2009. Vos et al. Sex Hormone Binding Globulin Deficiency Due to a Homozygous Missense Mutation. Journal of Clinical Endocrinology and Metabolism. Sept 2014 SHBG and Free Testosterone - Everything You Need to Know Hammes et al. Role of Endocytosis in Cellular Uptake of Sex Steroids. Cell. Sept 2005  

Estradiol in Men: What is the Most Accurate Blood Test? Table of Contents Estradiol in Men: What is the Most Accurate Blood Test? Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men Objective: Design and Setting: Main Outcome Measures: Results: Conclusions: BUY SENSITIVE ESTRADIOL TEST HERE  Recent studies show the importance of estradiol in men and how low estradiol can be detrimental for not only for bone but also for sex drive. Low estradiol has also been linked to fat gain. So, physicians should be careful about treating men who are obviously being over diagnosed with high estradiol due to the use of the wrong test. This study compares the old estradiol blood test assay (ECLIA) to the more accurate sensitive one (LC/MS/MS). The sensitive estradiol test is a method for measuring estradiol levels in men (and children) using a sensitive liquid chromatography-tandem mass spectrometry (LC/MS)-based assay[2]. It is considered more accurate for men because it provides better sensitivity and accuracy at lower estradiol concentrations, which are typically found in men, as opposed to higher concentrations found in adult females[1][2]. Immunoassay-based estradiol tests, on the other hand, perform best at higher concentrations of estradiol, making them more suitable for individuals with levels in the adult-female range[2]. The sensitive estradiol test, with its greater sensitivity at lower levels, is more appropriate for men who generally have lower levels of estradiol compared to adult females[3]. Comparisons of Immunoassay and Mass Spectrometry Measurements of Serum Estradiol Levels and Their Influence on Clinical Association Studies in Men  (Source: The Journal of Clinical Endocrinology & Metabolism, Volume 98, Issue 6, 1 June 2013, Pages E1097–E110)   Immunoassay-based techniques, routinely used to measure serum estradiol (E2), are known to have reduced specificity, especially at lower concentrations, when compared with the gold standard technique of mass spectrometry (MS). Different measurement techniques may be responsible for the conflicting results of associations between serum E2 and clinical phenotypes in men. Objective: Our objective was to compare immunoassay and MS measurements of E2 levels in men and evaluate associations with clinical phenotypes. Design and Setting: Middle-aged and older male subjects participating in the population-based Osteoporotic Fractures in Men (MrOS) Sweden study (n = 2599), MrOS US (n = 688), and the European Male Aging Study (n = 2908) were included. Main Outcome Measures: Immunoassay and MS measurements of serum E2 were compared and related to bone mineral density (BMD; measured by dual energy x-ray absorptiometry) and ankle-brachial index. Results: Within each cohort, serum E2 levels obtained by immunoassay and MS correlated moderately (Spearman rank correlation coefficient rS 0.53–0.76). Serum C-reactive protein (CRP) levels associated significantly (albeit to a low extent, rS = 0.29) with immunoassay E2 but not with MS E2 levels. Similar associations of immunoassay E2 and MS E2 were seen with lumbar spine and total hip BMD, independent of serum CRP. However, immunoassay E2, but not MS E2, associated inversely with ankle-brachial index, and this correlation was lost after adjustment for CRP (C Reactive Protein- An Inflammatory marker). Conclusions: Our findings suggest interference in the immunoassay E2 analyses, possibly by CRP or a CRP-associated factor. Although associations with BMD remain unaffected, this might imply for a reevaluation of previous association studies between immunoassay E2 levels and inflammation-related outcomes. BUY SENSITIVE ESTRADIOL TEST HERE   

When it comes to TRT blood pressure, understanding the various factors that can impact this crucial health metric is essential for men who use testosterone. In this blog post, we'll talk about the link between testosterone replacement therapy (TRT) and high blood pressure, as well as some of the possible side effects and problems that may come up during treatment. We'll talk about the dangers of TRT-induced high blood pressure and emphasize how crucial regular monitoring is. Additionally, we'll examine water retention and edema in men on TRT, shedding light on their causes and management strategies. Furthermore, our investigation into testosterone's impact on kidney functioning will provide valuable insights into how hormone therapy affects renal function. We'll also debunk common misconceptions surrounding estrogen conversion's role in extracellular water (ECW) increases while exploring alternative explanations for changes in fluid balance during TRT. Lastly, we'll address lifestyle factors influencing water retention during hormone therapy, such as sodium intake, alcohol consumption's effects on fluid balance, and the significance of regular exercise throughout treatment. By gaining a deeper understanding of these issues related to TRT, blood pressure management becomes an achievable goal for those undergoing hormone therapy. Table of Contents: High Blood Pressure and TRT Risks Associated with High Blood Pressure Caused by TRT Importance of Regular Blood Pressure Monitoring Water Retention and Edema in Men on TRT Causes Behind Edema-Related Swelling in Men on TRT Strategies for Managing Water Retention The Importance of Cardiovascular Workup Testosterone's Impact on Kidney Functioning The Role Played by Kidneys in Regulating Body Fluids How Testosterone Affects Renal Function Taking Control of Blood Pressure During TRT Estrogen Conversion Not Responsible for ECW Increase Debunking Misconceptions about Estrogen's Role in ECW Increase Investigating Alternative Explanations for Changes in Fluid Balance Moving Forward: The Importance of Ongoing Research Lifestyle Factors Influencing Water Retention During TRT The Role of Sodium Intake in Water Retention Effects of Alcohol Consumption on Fluid Balance Importance of Regular Exercise During Hormone Therapy FAQs in Relation to Trt Blood Pressure Does TRT therapy raise blood pressure? Does testosterone play a role in blood pressure? Can testosterone cypionate cause high blood pressure? Does low testosterone shots cause high blood pressure? Conclusion High Blood Pressure and TRT Several studies have determined that having low testosterone may increase the incidence of high blood pressure in men. TRT can improve blood pressure control in hypogonadal men. However, in some other men, testosterone replacement therapy (TRT) can increase blood pressure during the initial weeks of treatment. Monitoring your blood pressure is crucial to regaining control over it while on TRT. In this section, we will discuss the dangers of TRT-related high blood pressure and emphasize the significance of regular blood pressure monitoring. Risks Associated with High Blood Pressure Heart Attacks: Elevated blood pressure puts extra strain on your heart muscles, which may eventually lead to heart attacks. When arteries become narrow due to plaque buildup or a clot forms in one of these vessels supplying oxygen-rich blood to your heart muscle cells, it could cause permanent damage. Strokes: High blood pressure can also cause strokes, which occur when there's an interruption in the flow of oxygenated blood supply towards specific regions within our brains, leading them to not be able to function properly anymore, resulting in either death, tissue loss, or, depending upon severity, the location of the affected area(s). Kidney Damage: Prolonged hypertension may result in chronic kidney disease (CKD) due to the increased workload placed on these organs, which filter waste products out of the bloodstream efficiently enough for elimination via the urine production process, eventually leading to renal failure if left untreated over time. Erectile Dysfunction: High blood pressure can cause erectile dysfunction by damaging the lining of your blood vessels and limiting the flow of blood to your penis. This makes it difficult for men to achieve or maintain an erection during sexual activity. Brain Shrinkage: Studies have shown that high blood pressure may contribute to a reduction in brain volume, also known as brain shrinkage. This condition has been linked with cognitive decline and an increased risk of dementia later in life. Importance of Regular Blood Pressure Monitoring To mitigate these risks while undergoing TRT, it is essential to monitor your blood pressure regularly if it is increasing. Here are some reasons why regular monitoring is crucial: Detecting Early Warning Signs: Frequent measurements help identify any fluctuations in your BP levels before they escalate into more severe health issues such as heart attacks or strokes, allowing you to take preventive measures early on. Maintaining an Optimal Treatment Plan: By keeping track of how well current medications work in controlling hypertension symptoms (if applicable), doctors are able to adjust dosages accordingly to ensure the best possible outcome for patients' overall wellbeing throughout the duration of therapy sessions undertaken using testosterone replacement products/services available in today's medical industry standards, practices, guidelines, and recommendations set forth by medical groups. Lifestyle Adjustments: Tracking changes allows individuals to pinpoint specific factors contributing to their elevated pressure - whether it be dietary habits, stress levels, or lack of exercise regimen adherence, among others; thus enabling them to make necessary adjustments in order to improve their overall health status while still receiving the benefits associated with TRT treatments being administered under the supervision of healthcare professional team members involved in the case management process. In conclusion, understanding the risks of high blood pressure caused by testosterone replacement therapy and monitoring your BP regularly is essential for maintaining optimal health during treatment. By making lifestyle adjustments and working closely with your healthcare provider, you can effectively manage hypertension while reaping the benefits of TRT.   Key Takeaway:  In some men with metabolic syndrome, older age, and other factors, testosterone replacement therapy (TRT) can increase blood pressure, which poses long term risks such as heart attacks, strokes, kidney damage, erectile dysfunction, and brain shrinkage. Monitoring and treating your blood pressure is crucial to regain control over it while on TRT, and making lifestyle adjustments with the help of healthcare providers can effectively manage hypertension while reaping the benefits of TRT. Water Retention and Edema in Men on TRT One potential side effect of testosterone therapy is edema, particularly dependent edema, which is more common in older men [10]. Edema refers to water retention, and dependent indicates water retention towards the ground, such as when sock imprints are visible around the ankles after removing them. Testosterone-induced water retention can cause swelling in the extremities, particularly in the legs and feet, leading to discomfort and potential complications if left untreated. A study looking at various doses of testosterone enanthate in older men revealed nearly half experienced leg edema in the groups provided with supraphysiologic testosterone (300 and 600 milligrams per week of testosterone enanthate). A comprehensive cardiovascular workup may help identify any underlying issues contributing to this condition, while maintaining a low-sodium diet and drinking plenty of water can alleviate symptoms. In this section, we will discuss the causes behind edema-related swelling in men on TRT and strategies for managing water retention. Causes Behind Edema-Related Swelling in Men on TRT The primary cause of edema-related swelling during TRT is an increase in extracellular fluid volume resulting from testosterone's impact on sodium reabsorption in the kidneys. Testosterone stimulates sodium and water retention through an autocrine or paracrine mechanism that affects sodium metabolism, leading to elevated blood pressure levels experienced by some men undergoing hormone therapy. Men with pre-existing metabolic syndrome, obesity, baseline high blood pressure, and kidney dysfunction can be more susceptible than others to having this problem. Additionally, certain lifestyle factors, such as high sodium intake, alcohol consumption, and a lack of exercise, can exacerbate these symptoms. Strategies for Managing Water Retention To minimize the impact of TRT-induced edema and improve overall health outcomes, it is essential to adopt effective management strategies targeting both hormonal imbalances caused by treatment itself as well as lifestyle factors that contribute to fluid accumulation within the body: Maintain a Low-Sodium Diet: Reducing your daily salt intake helps prevent excessive fluid buildup around cells, which could lead to hypertension. Aim for less than 2300 mg per day, according to CDC guidelines. Stay Hydrated: Drinking adequate amounts of water helps flush out excess sodium and promotes healthy kidney function. Aim for at least eight 8-ounce glasses per day, or consult your healthcare provider for personalized recommendations based on individual needs. Incorporate Regular Exercise: Engaging in regular physical activity not only aids weight management but also improves circulation and reduces fluid retention. Choose activities that you enjoy, such as walking, swimming, or cycling, to maintain consistency. Minimize Alcohol Consumption: Alcohol can dehydrate the body and increase water retention by disrupting hormonal balance. Limiting alcohol intake will help minimize edema-related swelling during TRT. Monitor Blood Pressure Regularly: Keeping track of your blood pressure levels is crucial to ensuring they remain within a healthy range while undergoing hormone therapy. Invest in a reliable home blood pressure monitor and take readings daily until control is regained. Besides these strategies, it's essential to communicate with your healthcare provider about any concerns related to edema or other side effects experienced during TRT. They may recommend adjustments in dosage or additional medications such as diuretics (water pills), which aid in reducing fluid buildup within the body, if necessary. Physicians may also recommend lowering the TRT dose or switching from testosterone injections to gels to attain lower testosterone blood level peaks. The Importance of Cardiovascular Workup If you are experiencing persistent edema-related swelling despite implementing the above strategies, it might be time for a comprehensive cardiovascular workup conducted by a qualified medical professional specializing in men's health issues like testosterone deficiency (hypogonadism). A qualified medical professional specializing in men's health issues such as testosterone deficiency (hypogonadism) can perform a comprehensive cardiovascular workup to assess any underlying heart or vascular issues that may be contributing to fluid retention. In conclusion, managing water retention during TRT is crucial for maintaining optimal health outcomes while undergoing hormone therapy. By adopting effective strategies targeting both hormonal imbalances caused by treatment itself as well as lifestyle factors that contribute to fluid accumulation within the body, men on TRT can minimize edema-related swelling and improve their overall quality of life.   Key Takeaway:  Due to the effect of testosterone on kidney function, men receiving testosterone replacement therapy (TRT) may experience swelling associated with edema. To manage this side effect, men should maintain a low-sodium diet, stay hydrated, exercise regularly, minimize alcohol consumption, and monitor their blood pressure levels. If these strategies do not work, it is important to seek a comprehensive cardiovascular workup from a qualified medical professional specializing in men's health issues like hypogonadism. Testosterone's Impact on Kidney Functioning Increased extracellular water retention, which is a result of testosterone's impact on kidney function, may be the cause of elevated blood pressure levels in men undergoing TRT. One possible explanation for this phenomenon is the direct impact of testosterone on the way kidneys manage sodium in the body. In this section, we will explore the role played by kidneys in regulating body fluids and how testosterone affects renal function. The Role Played by Kidneys in Regulating Body Fluids Kidneys play a crucial role in maintaining overall health by filtering waste products from the bloodstream and excreting them as urine. Additionally, these vital organs are responsible for balancing electrolytes such as sodium and potassium while also controlling fluid balance within the body. This process involves adjusting both water intake through thirst signals and water output via urine production based on factors like hydration status, blood pressure levels, and hormone regulation. A key component of kidney function is its ability to regulate extracellular fluid volume (ECFV), which includes both interstitial fluid surrounding cells and plasma within blood vessels. ECFV directly impacts blood pressure since it determines the amount of circulating blood volume that needs to be pumped throughout the body by the heart. How Testosterone Affects Renal Function The primary effect of testosterone on the kidneys is the stimulation of sodium reabsorption. This means that the kidney cells are instructed to retain more sodium, which can lead to an increase in blood pressure. This is one of the reasons why testosterone replacement therapy is not recommended for men with hypertension unless blood pressure is managed first. Research has shown that testosterone could act directly on the kidneys through an autocrine or paracrine mechanism, stimulating sodium reabsorption along with increased water retention. This effect leads to a higher extracellular fluid volume, resulting in elevated blood pressure levels experienced by some men undergoing hormone therapy. Autocrine mechanism: Testosterone may act directly on the kidney cells that produce it, leading to an increase in sodium and water reabsorption. This process can contribute to elevated blood pressure levels by increasing extracellular fluid volume. Paracrine mechanism: Testosterone could also influence neighboring kidney cells through paracrine signaling, which involves the release of chemical messengers that travel short distances to affect nearby cells. In this case, testosterone might stimulate adjacent renal tubule cells responsible for regulating sodium and water balance within the body. In addition to these direct effects on kidney function, testosterone has been shown to impact other hormones involved in fluid regulation, such as aldosterone and vasopressin. For example, studies have found that men with low testosterone levels exhibit reduced aldosterone secretion, a hormone responsible for promoting sodium retention and potassium excretion by the kidneys. Consequently, when TRT is administered and testosterone levels rise again, there could be an associated increase in aldosterone production, resulting in greater sodium retention along with increased extracellular fluid volume. Taking Control of Blood Pressure During TRT If you are experiencing high blood pressure while undergoing TRT due to increased extracellular water retention caused by changes in renal function, hormonal imbalances related to treatment itself, or lifestyle factors like diet and exercise habits (as discussed earlier), it's essential to take proactive steps towards managing your condition effectively: Maintain regular check-ups with your healthcare provider. Your doctor will monitor your progress during TRT closely so they can adjust dosage if necessary or recommend additional interventions such as medication adjustments or lifestyle modifications aimed at reducing blood pressure levels. Monitor your blood pressure at home: Invest in a reliable home blood pressure monitor and take readings twice daily to keep track of any fluctuations that may occur during treatment. Maintain a healthy lifestyle: incorporate regular exercise, good hydration, a balanced diet low in sodium, limit alcohol consumption, and manage stress levels to help minimize the impact of TRT on blood pressure and overall health. In conclusion, understanding how testosterone impacts kidney function can provide valuable insights into managing high blood pressure during hormone therapy. By taking proactive steps towards maintaining optimal renal health while undergoing TRT, men can experience the benefits of this treatment without compromising their cardiovascular well-being.   Key Takeaway:  Testosterone replacement therapy (TRT) can lead to an increase in extracellular water retention, which contributes to elevated blood pressure levels. Testosterone impacts kidney function by stimulating sodium reabsorption and increasing water retention, resulting in a higher extracellular fluid volume that causes high blood pressure. To manage this condition effectively, it's essential to maintain regular check-ups with your healthcare provider, monitor your blood pressure at home, and maintain a healthy lifestyle. Estrogen Conversion May Not Be Responsible for Water Retention It was once believed that the increase in extracellular water (ECW) experienced by men undergoing testosterone replacement therapy (TRT) could be attributed to the conversion of testosterone into estrogen within peripheral tissues. However, recent research has debunked this hypothesis, indicating that other mechanisms must be at play when it comes to understanding how hormone treatments impact fluid balance within the body. In this section, we will explore why estrogen is not responsible for increased ECW and discuss alternative explanations for changes in fluid balance during TRT. Debunking Misconceptions about Estrogen's Role in ECW Increase The idea that estrogen might be responsible for increased ECW stemmed from its known effects on sodium and water retention. Indeed, studies have shown that elevated levels of estrogen can lead to an increase in total body water due to enhanced renal reabsorption of sodium and subsequent water retention. This led some researchers to speculate whether a similar mechanism might explain the observed rise in extracellular fluid volume among men receiving TRT. However, more recent investigations have demonstrated no significant correlation between circulating estradiol levels (the primary form of estrogen) and changes in extracellular fluid volume following testosterone administration. These findings imply that the aromatization, or conversion, of testosterone into estradiol cannot solely account for any increase in ECW experienced by men on TRT. Investigating Alternative Explanations for Changes in Fluid Balance In light of these discoveries, scientists are now considering other potential mechanisms that might account for the increase in ECW observed among men undergoing hormone therapy. One such possibility is that testosterone itself may directly affect kidney function, as discussed earlier in this article. Due to its modulation of secretion and action, testosterone levels may have an impact on vasopressin, a hormone that regulates the body's water balance.  Recent studies suggest that testosterone can also modulate vasopressin secretion. Vasopressin is a hormone that regulates water balance and blood pressure in the body. It is released from the pituitary gland and acts on the kidneys to regulate the amount of water excreted in urine. Research shows that testosterone can regulate the production and release of vasopressin in the hypothalamus, a region of the brain that plays a key role in regulating hormone secretion. Testosterone can enhance vasopressin secretion, which in turn can increase water reabsorption in the kidneys and reduce urine output. Therefore, testosterone can have an impact on the body's fluid balance, which can have implications for overall health and well-being. More research is needed to fully understand the complex relationship between testosterone and vasopressin secretion. A third hypothesis involves aldosterone, another hormone involved in maintaining proper electrolyte balance and blood pressure regulation.Testosterone has been found to stimulate aldosterone production, which could theoretically contribute to changes in ECW by promoting sodium retention and subsequent water reabsorption at the level of renal tubules. Another factor that may increase blood pressure is the effect of TRT on increasing red blood cells and hematocrit to high levels in some men.  High hematocrit can increase blood viscosity and blood pressure. In addition to these hormonal factors, it's important not to overlook lifestyle influences when examining changes in fluid balance during TRT. As mentioned previously, high-sodium diets, alcohol consumption, and a lack of exercise can all exacerbate water retention issues among men receiving hormone treatments. Moving Forward: The Importance of Ongoing Research While we now know that estrogen conversion is not responsible for increased ECW during TRT, there remains much work to be done when it comes to understanding how various factors influence fluid balance among individuals undergoing this form of therapy. Continued research into hormonal pathways - as well as individual differences related to both genetics and lifestyle choices - will help paint a clearer picture regarding how to best manage side effects like edema-related swelling while optimizing the overall benefits of TRT for men who need it. For now, it's essential that patients and healthcare providers alike remain vigilant when monitoring fluid balance during hormone therapy. By staying informed about the latest research findings and being proactive in addressing any potential issues related to water retention, men on TRT can minimize their risk of experiencing complications while maximizing the positive impact of treatment on their health and well-being.   Key Takeaway:  Recent research has debunked the hypothesis that estrogen is responsible for increased extracellular water (ECW) in men undergoing testosterone replacement therapy (TRT). Alternative explanations include direct effects of testosterone on kidney function, modulation of vasopressin secretion and action, and stimulation of aldosterone production. It's important to monitor fluid balance during hormone therapy and consider lifestyle influences such as high-sodium diets, alcohol consumption, and a lack of exercise. Lifestyle Factors Influencing Water Retention During TRT Men receiving testosterone replacement therapy (TRT) may experience increased water retention when consuming high-sodium foods, drinking alcohol, or skipping gym sessions for more than three days. Adjusting these lifestyle factors can help minimize the impact of TRT on blood pressure and fluid balance. The Role of Sodium Intake in Water Retention A diet high in sodium can cause your body to retain more water, leading to an increase in extracellular fluid volume. This is particularly true for men undergoing testosterone replacement therapy, as their bodies are already prone to retaining excess fluids due to the hormonal changes taking place. To combat this issue, it's essential that you monitor your daily sodium intake while on TRT. Limit processed foods: Processed and packaged foods often contain large amounts of hidden sodium. Opt for fresh fruits, vegetables, lean meats, and whole grains instead. Cook at home: Preparing meals at home allows you greater control over the amount of salt used in your dishes. Experiment with herbs and spices to add flavor without relying on salt. Read food labels: Pay attention to the nutritional information provided on food packaging so you're aware of how much sodium each product contains. Avoid dining out frequently: Restaurant meals tend to be higher in sodium compared to homemade options; limit eating out whenever possible. Effects of Alcohol Consumption on Fluid Balance In addition to increasing overall caloric intake and potentially contributing to weight gain, alcohol consumption can also have a negative impact on fluid balance in men undergoing TRT. Alcohol acts as a diuretic, causing your body to lose fluids and electrolytes through increased urine production. This loss of fluids can lead to dehydration, which may exacerbate blood pressure issues and water retention problems associated with testosterone therapy. To minimize the effects of alcohol on fluid balance during TRT: Limit alcohol intake: Aim for moderate drinking habits by consuming no more than two alcoholic beverages per day for men. Stay hydrated: Drink plenty of water throughout the day and especially when consuming alcohol to counteract its dehydrating effects. Avoid binge drinking: Consuming large amounts of alcohol in a short period increases the risk of dehydration and worsens blood pressure and water retention problems related to TRT. Importance of Regular Exercise During Hormone Therapy Maintaining an active lifestyle is crucial for overall health and well-being while undergoing hormone therapy. Regular exercise not only helps control weight gain but also plays a vital role in managing blood pressure levels and promoting healthy circulation. Additionally, physical activity has been shown to help reduce edema-related swelling caused by excess extracellular fluid buildup - one common side effect experienced by many men receiving testosterone treatment. Incorporate these tips into your fitness routine while on TRT: Create a consistent schedule: Aim for at least three days per week dedicated to cardiovascular exercises such as brisk walking, jogging, or swimming; consistency is key when it comes to maintaining optimal blood pressure levels during hormone therapy treatments like TRT. Incorporate strength training: Building muscle mass can help improve arterial stiffness and reduce the risk of cardiovascular disease and heart attacks. Monitor progress: Keep track of your progress and adjust your exercise routine as needed to ensure you're getting the most out of your workouts.   Key Takeaway:  Men undergoing testosterone replacement therapy (TRT) may experience increased water retention due to hormonal changes, which can impact blood pressure. To minimize the effects of TRT on fluid balance, it's important to monitor sodium intake, limit alcohol consumption, and maintain a regular exercise routine that includes both cardiovascular exercises and strength training. FAQs in Relation to TRT and Blood Pressure Does TRT therapy raise blood pressure? TRT therapy can potentially raise blood pressure in some individuals, especially if they have pre-existing hypertension or other cardiovascular risk factors. However, the effect varies from person to person and depends on individual health conditions and lifestyle factors. Regular monitoring of blood pressure is essential during TRT. Does testosterone play a role in blood pressure? Testosterone does play a role in regulating blood pressure by influencing vascular function, kidney function, and body fluid balance. However, its impact on an individual's blood pressure may vary depending on various factors such as age, overall health status,the presence of pre-existing metabolic syndrome or cardiovascular issues, hormone levels, and lifestyle choices. Can testosterone cypionate cause high blood pressure? Testosterone cypionate is a form of injectable testosterone used for TRT. It has the potential to cause high blood pressure in some men due to increased water retention or changes in renal function associated with higher testosterone levels. Monitoring your BP regularly while using this medication is important. Does low testosterone shots cause high blood pressure? Low-testosterone shots are typically administered as part of TRT when treating hypogonadism (low T). These injections can sometimes lead to elevated BP due to increased water retention or altered kidney functions; however, it doesn't happen universally among all patients undergoing treatment. Maintaining healthy habits like exercising regularly and reducing sodium intake will help mitigate the risks associated with elevated blood pressure. Conclusion Therefore, it is essential to monitor blood pressure regularly in order to avoid potential cardiovascular complications associated with TRT. Regular monitoring of blood pressure is crucial to preventing cardiovascular disease and other related health issues. While TRT can have a positive impact on muscle mass and metabolic syndrome, it's important to manage any side effects that may arise. If you're interested in learning more about the role of the pituitary and thyroid in the diagnosis and treatment of TRT blood pressure, check out this informative article from  Testosterone Wisdom. Take control of your health today by educating yourself on the benefits and risks associated with TRT blood pressure management!        

Table of Contents The 6 Most Popular Discounted Lab Panels Online Why Using Direct-to-Consumer Labs? How Do Online Lab Tests Work? What Lab Tests Can You Choose? What Are the Most Popular Blood Tests Online? 1. Heavy Metal Test Symptoms of Heavy Metal Poisoning 2. Hormone and Wellness Panels for Men and Women 3. Comprehensive Fatigue Panel 4. Erectile Dysfunction ED Panel 5. Electrolyte Panel 6. Elite Male Blood Test Panel Get Your Blood Test Today! The 6 Most Popular Discounted Lab Panels Online   According to the World Health Organization, chronic diseases kill millions of people each year. Diabetes alone accounted for nearly 1.6 million deaths in 2015. Deaths caused by neurodegenerative diseases such as dementia doubled since 2000, and this number is expected to grow in the upcoming years. Although these are alarming facts, you might be happy to find out that numerous diseases and injuries, particularly chronic illnesses, can be prevented. To prevent a disease, you first need to be aware of it. To be aware of it, you need to do the right thing and get your health checked periodically. Discovering a predisposition to the disease earlier on gives you a massive advantage. You’ll be able to follow special treatments and minimize its risks or eliminate them. But how to get tested for various diseases which might affect you? Well, one of the simplest and most efficient ways is by using direct-to-consumer labs. These are usually discount labs you can purchase online at affordable prices and have your general health checked in a matter of days. Why Using Direct-to-Consumer Labs? Direct-to-consumer labs are discounted labs sold by various companies such as DiscountedLabs.com. Many people decide to buy their lab tests instead of working with their primary physicians because this route offers numerous advantages. For example: You can choose your preferred test from hundreds of labs available online You save money since you eliminate the middle man and buy "directly from the source” and not having to pay for a doctor’s visit copay. You get your results back in just a few business days.  Your information and results are confidential and secure You can draw blood or offer a urine sample in the nearest clinic from your house You have more control over your health More and more people are taking advantage of this opportunity to buy a cheap blood test and become more aware of their health, so why shouldn’t you? How Do Online Lab Tests Work? Getting a blood test online is not rocket science. The procedure has just a few steps: 1. Order your preferred test from DiscountedLabs.com 2. Get a form which allows you to go to the nearest lab or clinic to draw blood that you can download after your purchase. 3. Have your blood samples analyzed by a Quest Diagnostics laboratory in your state or the nearest state. 4. The results will be available for you to download in 5-7 business days from the day of your lab blood draw. 5. You can visit your doctor to help you interpret these results or compare them against reference values you find online As you can see, the process is simple, confidential and secure. You don’t even have to visit your doctor for a prescription since DiscountedLabs.com provides that for you. What Lab Tests Can You Choose? There are numerous things you can test in a human body using just a blood, urine or saliva sample. For example, some of the most popular tests include a complete blood count test which tells you how much hemoglobin there is in your blood, the number, and type of your blood cells, etc. You can also go for a pregnenolone test or a cheap testosterone test to determine your testosterone levels. Cheap blood tests are also available, and they can show information about your cholesterol levels, triglycerides, inflammation biomarkers and more. Buying a testosterone test online is increasingly popular especially if you’re a bodybuilder and you want to monitor your T levels or if you think you have testosterone deficiency. DiscountedLabs.com offers dozens of affordable tests for both men and women, so you have a lot of options at your disposal when it comes to taking care of your health. What Are the Most Popular Blood Tests Online? If you’re buying for the first time and you don’t know what to focus on, keep reading to find out a list of some of the most popular direct-to-consumer labs you can buy today. These tests can be obtained using a discounted labs coupon to help you save some money in the process. Here is a way to compare all discounted lab panels to see which one is best for you. 1. Heavy Metal Test The dangers of having heavy metals in your body are real. The heavy metals category includes mercury, arsenic, cadmium, lead and other types of toxic substances. These elements can stick to your bones and organs, causing serious health problems in the long run. The body can easily eliminate trace amounts of heavy metals regularly. However, if you get too high of a quantity of arsenic, for example, you're exposed to serious health risks. Lead is one of the most poisonous heavy metal out there. It can cause brain damage, depression, anxiety, and even panic attacks. Testing for heavy metals can be done using a single blood sample or a urine sample. The Heavy Metals Profile I is performed using a blood sample, and it determines the levels of arsenic, mercury, and lead in your body. There are two more tests sold by DiscountedLabs such as the heavy metal profile II and the urine test. These also come at affordable prices and allow you to discover the levels of cadmium, lead, and arsenic in your system. Symptoms of Heavy Metal Poisoning Having a high amount of toxic metals in your body puts you in a risky situation, so you need to see your doctor immediately if this happens. Moreover, you’ll be able to experience certain symptoms along the way, and you shouldn’t ignore them. These symptoms depend on the type of metal which caused the poisoning. For example, these symptoms are common among people: l Stomach pain l Diarrhea l Nausea l Dizziness l Tingling in your feet l Weakness and headaches l Vomiting Some of these symptoms are your body's desperate attempt to eliminate the accumulated heavy metals. Help your body by getting tested for heavy metals immediately and find out if you're at risk. 2. Hormone and Wellness Panels for Men and Women Any hormonal imbalance you might experience can drastically influence your health. For example, testosterone deficiency can lead to poor sex drive and even symptoms of anxiety and depression in men of all ages. Instead of looking for “testosterone testing near me” on Google, you can order a testosterone test online and have your hormonal levels checked quickly. In women, estrogen levels are the most important. One of the most popular estrogens is estradiol. This hormone directly influences mood, cognition, sex drive, libido, and other functions in women. It is also possible to check the estradiol levels for men and see if they are elevated. Very high estradiol levels in men might be caused by testosterone replacement therapy. This is a rare but known side effect of TRT, but it can be minimized with certain medications. Another common side effect of TRT has high hematocrit. If you’re wondering what high hematocrit mean then you should know that this is the percentage of red blood cells in the blood. An elevated hematocrit might cause various health problems in the long run. Donating blood can be the answer if you’re wondering how to lower hematocrit on TRT, donating blood can be the answer. However, you shouldn’t donate blood more often than one or two times per year because this can lower your ferritin levels which causes anemia. There are high hematocrit symptoms to which you should pay attention. For example, having high hematocrit levels can lead to: l Fatigue l Itching l Bone pain l Blurred vision l Excessive sweating As you can see, there are numerous important hormones you need to be mindful of such as testosterone, estrogen, estradiol, ferritin, etc. A complete hormone and wellness panel can make your life easier because it provides a complete overview of your health. DiscountedLabs.com sells a Complete Hormone & Wellness Panel for MEN and a Hormone & Wellness Panel for WOMEN, so pick the one suitable for you to learn more about your hormonal health. 3. Comprehensive Fatigue Panel If you feel tired after a long day at work, it’s normal to be so, especially if you also found some time to visit a local gym for half an hour. However, if you constantly feel tired, even in the morning when you wake up, then this is not normal. Diagnosing excessive fatigue is not that easy. There are numerous potential causes which need to be analyzed independently. For example, here are a few factors which might directly influence your energy levels and how tired you feel regularly: l Your thyroid function l Whether you have hyperglycemia or hypoglycemia l Your total and free testosterone levels l The amount of iron in your blood cells l The number of red blood cells in the blood l Any adrenal problems you might have One hormonal imbalance in these areas can make you feel excessively tired. Also, keep in mind that such health problems don’t get corrected on their own. You need to do a thorough health checkup and see what causes your tiredness. A comprehensive fatigue panel takes all these factors into account and analyzes multiple hormones and substances in your bloodstream. Based on the results, your doctor can make appropriate health recommendations. For example, people who have low energy levels as a result of insufficient iron in their bloodstream might need to take an iron supplement. Similarly, those who have low testosterone levels might benefit from TRT or various lifestyle changes to improve their total and free testosterone levels. 4. Erectile Dysfunction ED Panel Another commonly purchased panel is the ED blood test. Unfortunately, the prevalence of erectile dysfunction is quite high, especially among men who are 40 years old or older. However, this health condition can be treated in numerous ways. There are both invasive and non-invasive procedures as well as pills which can improve the symptoms of erectile dysfunction. Certain lifestyle changes can also improve one's erection. However, the most important thing is to know exactly what caused the ED and how to treat it efficiently. For example, having low testosterone levels can lead to erectile dysfunction in men of all ages. In this case, TRT might be the appropriate treatment method to improve libido. Similarly, high estradiol can also be linked to erectile problems. Estradiol is a female sex hormone. If there is too much (or even too little) estradiol in the bloodstream, the person in question will experience erectile dysfunction. ED can also be caused by thyroid problems. For example, the TSH, T3, and T4 are all thyroid hormones which directly influence the production of testosterone and sex drive in general. If these hormones are out of balance, one might not be in the mood for sex that often. Prolactin is another important hormone in the body. It is produced by the pituitary gland, and if it’s not secreted correctly, ED can appear in men. As you can see, there are numerous factors which influence sex drive. The Erectile Dysfunction Panel which can be bought from DiscountedLabs.com looks at all these hormones to determine which one is out of balance. All you need to do is to buy the panel online and go to your nearest lab for a blood sample. The results will be communicated to you in a few business days, and then you can begin looking for appropriate solutions to your ED problem. 5. Electrolyte Panel Electrolytes are important substances in the human body. The most popular ones are potassium and sodium. Other electrolytes include chloride and carbon dioxide. The job of electrolytes is to regulate important bodily functions such as maintaining correct blood pH, muscle and nerve function. When electrolytes go out of balance, various physical symptoms can appear. For example, too much sodium in the body makes the blood acidic. This can lead to chronic illnesses in the long run. At the same time, too much potassium can cause heart problems and other similar health conditions. The Electrolyte Panel which can be bought from DiscountedLabs.com looks at four different important electrolytes in the body such as carbon dioxide, chloride, potassium, and sodium. This is one of the most affordable blood tests online, and it requires only a small blood sample to run it. 6. Elite Male Blood Test Panel If you want to have a broader overview of your health, the Elite Male Blood Test Panel is highly recommended for you. This is one of the most comprehensive panels sold on DiscountedLabs and one of the most affordable in the United States. Using just a simple blood sample, you get to find out more information about multiple hormones, enzymes, and substances in your body such as testosterone, prolactin, thyroid hormones, IGF-1, PSA and more. This panel looks at more than ten different hormones in your bloodstream, helping you diagnose certain conditions or preventing more serious diseases. A lipid panel is also included in this package, revealing information about your good cholesterol, bad cholesterol, and triglyceride levels. Another important hormone checked by this panel is sensitive estradiol. This hormone is linked to sex drive, and if it is in high quantities, it can lead to gynecomastia which is also known as “male boobs.” The estradiol levels might increase as a result of testosterone replacement therapy. If you’re currently using TRT, you might want to get this panel to find out if you’re prone to develop gynecomastia in the future. The Elite Male Blood Test Panel also looks at your complete blood count. It analyzes your hematocrit, the number of red blood cells, the amount of hemoglobin in your bloodstream, etc. Knowing more information about red blood cells helps you determine if you’re predisposed to anemia. Similarly, having a high hematocrit can cause problems in the long run so that you can monitor this important parameter with the Elite Male Panel. Another important aspect checked by this panel is the metabolic function. More precisely, the test looks at the kidney and liver health. As you probably already know, your liver is one of the most important organs in the body. It is responsible for eliminating toxins and producing numerous hormones required for a healthy living. Once you know the state of your liver, you'll be able to make appropriate lifestyle changes to improve its function. The same story goes for your kidneys. For example, creatinine is a byproduct which needs to be excreted by the kidneys. If this process doesn't happen correctly, you can develop kidney problems in the future. The Elite Male Blood Panel helps you look at all these vital aspects and have a broader understanding of your health. Get Your Blood Test Today! As you can see, ordering direct-to-consumer labs is efficient, more affordable and saves time. You don’t have to search for “discounted labs tests near me” on Google anymore; the answer comes directly from DiscountedLabs.com.  

Testosterone replacement therapy is an important treatment option for men with low testosterone and symptomatic hypogonadism. Various formulations of exogenous (supplemental) testosterone replacement therapy exist, including oral, buccal, intramuscular, transdermal, subdermal, and nasal preparations. However, exogenous testosterone replacement therapy is a double-edged sword, posing risks to fertility due to negative feedback mechanisms on the hypothalamic-pituitary-gonadal (HPG) axis, which is the primary regulator of testosterone production and sperm production in men.  Testosterone replacement therapy (TRT) is one of the most effective ways to combat low testosterone levels, but you must understand the risks associated with the treatment. As with any hormone replacement therapy, there are a few downsides to receiving regular testosterone injections. But do these risks outweigh the benefits? That’s a decision you’ll have to make for yourself!   Testosterone replacement therapy- Target Blood Test Limits: To minimize TRT side effects, different medical guideline groups have created lab test value ranges and maximum acceptable targets . These values have been collected from three TRT guidelines and clinical practices around the United States: Hematocrit (percent of red blood cells in plasma) under 53 PSA (Prostatic specific antigen) under 3 (4 is max since doctors will not prescribe TRT at this number) Estradiol (sensitive) between 20-50 pg/mL. However, if you have high testosterone, estradiol will be "high" per Quest or Labcorp since 0.4% of total testosterone aromatizes to estradiol. Blood pressure under 135/85 Estimated Glomerular (eGFR) (kidney function) over 60 Liver enzymes not elevated over 20 percent of top value of reference range Total Testosterone over 450 ng/dL Free Testosterone equal or above 2 percent of total If donating blood to bring hematocrit down, ferritin should never under 30 ng/mL or micrograms/liter (this could lead to fatigue) Free T3 (if hypothyroid and on treatment) in the upper quartile of range. (depending on range it can be 3.7- 4.2 pg/mL) HDL over 40 mg/dL (higher TRT doses can lead to decreased HDL cholesterol) You can order these lab tests here: TRT Male Hormone/Wellness Follow-Up Panel PSA Lipid Panel Thyroid Panel